COLORECTAL CANCER PATHWAY (PW:0000612)
Description
Colorectal cancer (CRC) affects both men and women and is a rather prevalent condition in the Western world. A number of pathways are known to be altered in CRC; they include the canonical Wnt, transforming growth factor-beta, Smad dependent and the extracellular signal-regulated Raf/Mek/Erk signaling pathways and the regulatory DNA mismatch repair pathway. While mutations in components of some of these pathways may be implicated in other forms of cancer and/or types of diseases, the diagram depicts those associated with the incidence of CRC. Mutations in components of the canonical Wnt pathway lead to a constitutively active beta-catenin, the core component of the pathway. Mutations in the Apc gene are associated with adenomatous polyposis, a form of colorectal cancer; loss-of-function mutations in Axin 1 and 2 have been detected in rare cases. Apc along with Axin1 and 2 are components of the 'degradation complex' which in the absence of the wnt signal, sequesters beta-catenin in the cytoplasm, leading to its phosphorylation, subsequent ubiquitination and degradation. Mutations in beta-catenin itself are clustered within an N-terminal region harboring the residues essential for its phosphorylation. In the altered TGF-beta Smad dependent signaling, the normal tumor suppressing function of the pathway is switched to a tumor stimulating one by mechanisms that are poorly understood. Mutations in ligand and receptors as well as in the Smad components of the pathway have been linked to colorectal and many other types of cancer. Altered DNA mismatch repair pathway (MMR) has long been identified as a primary cause of the hereditary colorectal cancer and it has also been shown to relate to a fraction of the sporadic form of the disease. Mutations have been found in the Msh2 and 6 homologs of E. coli MutS and the Mlh1, Pms1 and 2 homologs of E. coli MutL. The MMR pathway, conserved from bacterium to man, has been well characterized in E.coli and for eukaryotes, in S. cerevisiae. MutS is involved in the first step of mismatch recognition while MutL couples this event to next steps in the pathway. Other genes whose mutations have been implicated in CRC disease pathway (for some, with contradictory evidence) include Braf, the upper kinase tier of the Raf/Mek/Erk MAPK signaling pathway, Kras upstream of it (and of other pathways) and the p53 transcription factor. In addition, several miRNA have been reported to be aberrantly expressed; interestingly some of the donwregulated miRNAs are p53 targets. Colorectal cancer is one of several types of tumors for which platinum (Pt)-containing drugs such as cisplatin are used as chemotherapy agents.
To see the ontology report for annotations, GViewer and download click here To see the Disease Ontology report for genes that in some fashion have been associated with colorectal neoplasms or suspected to confer susceptibility,
click here To link to the Cancer Disease Portal, cli
ck here [click to see the associated KEGG map -
map005210 ]
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Pathway Diagram:
Genes in Pathway:
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Akt1
AKT serine/threonine kinase 1
IEA
KEGG
rno:05210
NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:131,713,720...131,733,921
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Akt2
AKT serine/threonine kinase 2
IEA
KEGG
rno:05210
NCBI chr 1:92,004,705...92,061,420
Ensembl chr 1:82,883,547...82,933,817
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Akt3
AKT serine/threonine kinase 3
IEA
KEGG
rno:05210
NCBI chr13:91,475,839...91,758,060
Ensembl chr13:88,946,091...89,225,708
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Apc
APC regulator of WNT signaling pathway
ISO IEA
KEGG RGD
PMID:18432252
rno:05210, RGD:2293188
NCBI chr18:26,138,382...26,196,021
Ensembl chr18:25,864,222...25,922,696
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Apc2
APC regulator of WNT signaling pathway 2
IEA
KEGG
rno:05210
NCBI chr 7:10,043,010...10,065,037
Ensembl chr 7:9,392,336...9,414,310
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Appl1
adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1
IEA
KEGG
rno:05210
NCBI chr16:2,125,234...2,173,457
Ensembl chr16:2,121,255...2,166,692
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Axin1
axin 1
ISO IEA
KEGG RGD
PMID:18432252
rno:05210, RGD:2293188
NCBI chr10:15,667,894...15,720,092
Ensembl chr10:15,163,684...15,215,615
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Axin2
axin 2
ISO IEA
KEGG RGD
PMID:18432252
rno:05210, RGD:2293188
NCBI chr10:94,393,379...94,426,579
Ensembl chr10:93,899,245...93,926,231
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Bad
BCL2-associated agonist of cell death
IEA
KEGG
rno:05210
NCBI chr 1:213,562,719...213,572,034
Ensembl chr 1:204,131,501...204,142,823
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Bax
BCL2 associated X, apoptosis regulator
IEA
KEGG
rno:05210
NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:95,938,808...95,945,368
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Bcl2
BCL2, apoptosis regulator
IEA
KEGG
rno:05210
NCBI chr13:23,204,464...23,366,900
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
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Birc5
baculoviral IAP repeat-containing 5
IEA
KEGG
rno:05210
NCBI chr10:103,567,369...103,580,069
Ensembl chr10:103,073,408...103,081,380
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Braf
B-Raf proto-oncogene, serine/threonine kinase
ISO IEA
KEGG RGD
PMID:18098337
rno:05210, RGD:2298531
NCBI chr 4:69,329,772...69,476,931
Ensembl chr 4:68,384,649...68,510,463
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Casp3
caspase 3
IEA
KEGG
rno:05210
NCBI chr16:52,395,539...52,413,794
Ensembl chr16:45,662,910...45,684,648
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Casp9
caspase 9
IEA
KEGG
rno:05210
Ensembl chr 5:154,109,046...154,126,626
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Ccnd1
cyclin D1
IEA
KEGG
rno:05210
NCBI chr 1:209,518,288...209,527,986
Ensembl chr 1:200,089,002...200,098,602
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Ctnnb1
catenin beta 1
ISO IEA
KEGG RGD
PMID:18432252
rno:05210, RGD:2293188
NCBI chr 8:129,517,576...129,544,661
Ensembl chr 8:120,639,995...120,667,111
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Cycs
cytochrome c, somatic
IEA
KEGG
rno:05210
NCBI chr 4:80,982,667...80,984,767
Ensembl chr 4:79,651,378...79,654,054 Ensembl chr18:79,651,378...79,654,054
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Cyct
cytochrome c, testis
IEA
KEGG
rno:05210
NCBI chr 3:61,290,090...61,297,158
Ensembl chr 3:60,913,562...61,297,158
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Dcc
DCC netrin 1 receptor
IEA
KEGG
rno:05210
NCBI chr18:67,144,272...68,248,159
Ensembl chr18:64,873,898...65,972,740
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Fos
Fos proto-oncogene, AP-1 transcription factor subunit
IEA
KEGG
rno:05210
NCBI chr 6:110,852,188...110,855,054
Ensembl chr 6:105,121,170...105,124,036
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Gsk3b
glycogen synthase kinase 3 beta
IEA
KEGG
rno:05210
NCBI chr11:76,004,502...76,154,665
Ensembl chr11:62,504,316...62,648,646
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Jun
Jun proto-oncogene, AP-1 transcription factor subunit
IEA
KEGG
rno:05210
NCBI chr 5:115,009,900...115,012,993
Ensembl chr 5:109,893,145...109,897,656
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Kras
KRAS proto-oncogene, GTPase
TAS IEA
KEGG RGD
PMID:16112461
rno:05210, RGD:2306732
NCBI chr 4:179,916,255...179,949,613
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Lef1
lymphoid enhancer binding factor 1
IEA
KEGG
rno:05210
NCBI chr 2:222,340,541...222,453,931
Ensembl chr 2:219,666,592...219,779,794
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Map2k1
mitogen activated protein kinase kinase 1
IEA
KEGG
rno:05210
NCBI chr 8:73,578,747...73,650,184
Ensembl chr 8:64,683,449...64,755,147
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Mapk1
mitogen activated protein kinase 1
IEA
KEGG
rno:05210
NCBI chr11:97,462,025...97,529,193
Ensembl chr11:83,957,813...84,023,616
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Mapk10
mitogen activated protein kinase 10
IEA
KEGG
rno:05210
NCBI chr14:6,802,247...7,094,103
Ensembl chr14:6,497,707...6,786,201
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Mapk3
mitogen activated protein kinase 3
IEA
KEGG
rno:05210
NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:181,366,637...181,372,863
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Mapk8
mitogen-activated protein kinase 8
IEA
KEGG
rno:05210
NCBI chr16:8,645,171...8,728,225
Ensembl chr16:8,638,924...8,721,981
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Mapk9
mitogen-activated protein kinase 9
IEA
KEGG
rno:05210
NCBI chr10:34,670,750...34,711,972
Ensembl chr10:34,169,675...34,210,178
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Mlh1
mutL homolog 1
ISO IEA
KEGG RGD
PMID:11900875
rno:05210, RGD:2306714
NCBI chr 8:120,074,871...120,112,109
Ensembl chr 8:111,196,468...111,233,617
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Msh2
mutS homolog 2
ISO IEA
KEGG RGD
PMID:11900875
rno:05210, RGD:2306714
NCBI chr 6:12,567,368...12,626,534
Ensembl chr 6:6,813,795...6,872,938
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Msh3
mutS homolog 3
IEA
KEGG
rno:05210
NCBI chr 2:23,444,326...23,585,777
G
Msh6
mutS homolog 6
ISO
RGD
PMID:11900875
RGD:2306714
NCBI chr 6:12,316,190...12,333,505
Ensembl chr 6:6,562,632...6,579,956
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Myc
MYC proto-oncogene, bHLH transcription factor
IEA
KEGG
rno:05210
NCBI chr 7:95,483,105...95,488,031
Ensembl chr 7:93,593,705...93,598,630
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Pik3ca
phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
IEA
KEGG
rno:05210
NCBI chr 2:117,103,643...117,177,411
Ensembl chr 2:115,174,984...115,249,032
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Pik3cb
phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta
IEA
KEGG
rno:05210
NCBI chr 8:108,474,017...108,579,140
Ensembl chr 8:99,594,644...99,699,663
G
Pik3cd
phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta
IEA
KEGG
rno:05210
NCBI chr 5:165,377,994...165,426,620
Ensembl chr 5:160,094,952...160,120,930
G
Pik3r1
phosphoinositide-3-kinase regulatory subunit 1
IEA
KEGG
rno:05210
NCBI chr 2:34,612,946...34,697,660
Ensembl chr 2:32,882,032...32,963,631
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Pik3r2
phosphoinositide-3-kinase regulatory subunit 2
IEA
KEGG
rno:05210
NCBI chr16:18,699,389...18,708,045
Ensembl chr16:18,665,457...18,674,065
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Pik3r3
phosphoinositide-3-kinase regulatory subunit 3
IEA
KEGG
rno:05210
NCBI chr 5:134,936,790...135,009,303
Ensembl chr 5:129,701,229...129,772,583
G
Pik3r5
phosphoinositide-3-kinase, regulatory subunit 5
IEA
KEGG
rno:05210
NCBI chr10:53,631,469...53,699,550
Ensembl chr10:53,132,603...53,199,374
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Pms1
PMS1 homolog 1, mismatch repair system component
ISO
RGD
PMID:11900875
RGD:2306714
NCBI chr 9:55,721,393...55,832,225
Ensembl chr 9:48,253,410...48,340,237
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Pms2
PMS1 homolog 2, mismatch repair system component
ISO
RGD
PMID:11900875
RGD:2306714
NCBI chr12:15,790,478...15,814,790
Ensembl chr12:10,676,764...10,701,066
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Rac1
Rac family small GTPase 1
IEA
KEGG
rno:05210
NCBI chr12:16,150,411...16,170,864
Ensembl chr12:11,036,698...11,057,251
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Rac2
Rac family small GTPase 2
IEA
KEGG
rno:05210
NCBI chr 7:111,981,825...112,009,201
Ensembl chr 7:110,116,260...110,128,720
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Raf1
Raf-1 proto-oncogene, serine/threonine kinase
IEA
KEGG
rno:05210
NCBI chr 4:150,352,158...150,412,813
Ensembl chr 4:148,679,530...148,740,317
G
Ralgds
ral guanine nucleotide dissociation stimulator
IEA
KEGG
rno:05210
NCBI chr 3:32,237,644...32,278,045
Ensembl chr 3:11,839,416...11,880,059
G
Rhoa
ras homolog family member A
IEA
KEGG
rno:05210
NCBI chr 8:117,870,548...117,904,303
Ensembl chr 8:108,991,954...109,025,746
G
RSA-14-44
RSA-14-44 protein
IEA
KEGG
rno:05210
NCBI chr 4:95,251,657...95,253,029
Ensembl chr 4:95,251,610...95,253,088
G
Smad2
SMAD family member 2
ISO IEA
KEGG RGD
PMID:17613544 PMID:18662538
rno:05210, RGD:2306282 , RGD:2308865
NCBI chr18:72,124,792...72,193,345
Ensembl chr18:69,850,377...69,912,323
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Smad3
SMAD family member 3
ISO IEA
KEGG RGD
PMID:17613544
rno:05210, RGD:2306282
NCBI chr 8:73,022,204...73,132,324
Ensembl chr 8:64,110,039...64,236,960
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Smad4
SMAD family member 4
ISO IEA
KEGG RGD
PMID:17613544 PMID:18662538
rno:05210, RGD:2306282 , RGD:2308865
NCBI chr18:69,518,988...69,549,684
Ensembl chr18:67,243,742...67,274,438
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Smad7
SMAD family member 7
ISO
RGD
PMID:18662538
RGD:2308865
NCBI chr18:71,263,508...71,291,849
Ensembl chr18:68,988,429...69,016,765
G
Tcf3
transcription factor 3
IEA
KEGG
rno:05210
NCBI chr 7:9,931,251...9,952,994
Ensembl chr 7:9,280,571...9,302,314
G
Tcf7
transcription factor 7
IEA
KEGG
rno:05210
NCBI chr10:36,924,363...36,954,279
Ensembl chr10:36,423,445...36,453,535
G
Tcf7l2
transcription factor 7 like 2
IEA
KEGG
rno:05210
NCBI chr 1:264,791,335...264,984,225
Ensembl chr 1:254,786,091...254,978,967
G
Tgfb1
transforming growth factor, beta 1
ISO IEA
KEGG RGD
PMID:17613544
rno:05210, RGD:2306282
NCBI chr 1:90,324,312...90,340,627
Ensembl chr 1:81,196,532...81,212,847
G
Tgfb2
transforming growth factor, beta 2
IEA
KEGG
rno:05210
NCBI chr13:100,691,540...100,793,227
Ensembl chr13:98,160,087...98,261,405
G
Tgfb3
transforming growth factor, beta 3
IEA
KEGG
rno:05210
NCBI chr 6:111,435,170...111,457,646
Ensembl chr 6:105,704,236...105,726,564
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Tgfbr1
transforming growth factor, beta receptor 1
ISO IEA
KEGG RGD
PMID:17613544
rno:05210, RGD:2306282
NCBI chr 5:66,449,348...66,506,371
Ensembl chr 5:61,653,233...61,710,777
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Tgfbr2
transforming growth factor, beta receptor 2
ISO IEA
KEGG RGD
PMID:17613544 PMID:18662538
rno:05210, RGD:2306282 , RGD:2308865
NCBI chr 8:124,672,677...124,761,741
Ensembl chr 8:115,794,537...115,883,228
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Tp53
tumor protein p53
IEA
KEGG
rno:05210
NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,300,048...54,311,524
Pathway Gene Annotations
Disease Annotations Associated with Genes in the colorectal cancer pathway
Akt1 Acute Lung Injury , acute promyelocytic leukemia , adenocarcinoma , alcoholic hepatitis , Alcoholic Liver Diseases , Alzheimer's disease , amphetamine abuse , amyotrophic lateral sclerosis , Animal Disease Models , atherosclerosis , autosomal recessive polycystic kidney disease , bipolar disorder , Brain Injuries , brain ischemia , breast adenocarcinoma , breast cancer , Breast Cancer, Familial , Breast Neoplasms , Calcification of Aortic Valve , cannabis abuse , Carcinogenesis , cardiac arrest , Cardiomegaly , cardiomyopathy , Charcot-Marie-Tooth disease axonal type 2O , chronic myeloid leukemia , colon cancer , colon carcinoma , colorectal cancer , Colorectal Neoplasms , coronary artery disease , Cowden syndrome 6 , Diabetic Cardiomyopathies , diabetic retinopathy , Endotoxemia , epilepsy , esophageal cancer , esophageal carcinoma , esophagus squamous cell carcinoma , Experimental Arthritis , Experimental Colitis , Experimental Diabetes Mellitus , Experimental Liver Cirrhosis , Experimental Mammary Neoplasms , familial adenomatous polyposis , Fibrosis , focal segmental glomerulosclerosis 5 , genetic disease , glioblastoma , head and neck squamous cell carcinoma , hepatocellular carcinoma , Hepatomegaly , Hereditary Neoplastic Syndromes , heroin dependence , Herpes Simplex Encephalitis 3 , Hyperplasia , hypertension , Hypertriglyceridemia , idiopathic pulmonary fibrosis , impotence , in situ carcinoma , Inflammation , intermediate coronary syndrome , Intervertebral Disc Displacement , invasive ductal carcinoma , Kidney Neoplasms , Lung Neoplasms , lung non-small cell carcinoma , Macrocephaly Mesodermal Hamartoma Spectrum , malignant astrocytoma , Memory Disorders , meningioma , metabolic dysfunction and alcohol associated liver disease , metabolic dysfunction-associated steatohepatitis , metabolic dysfunction-associated steatotic liver disease , muscular atrophy , myocardial infarction , Myocardial Reperfusion Injury , Neointima , obesity , opiate dependence , ovarian cancer , Ovarian Neoplasms , Pain , pancreatic cancer , pancreatic intraductal papillary-mucinous neoplasm , paraplegia , Parkinson's disease , pre-malignant neoplasm , prostate adenocarcinoma , prostate cancer , Prostatic Neoplasms , Proteus syndrome , pulmonary tuberculosis , renal cell carcinoma , Reperfusion Injury , Right Ventricular Hypertrophy , schizophrenia , Skin Neoplasms , Spinal Cord Injuries , squamous cell carcinoma , Staphylococcal Pneumonia , steatotic liver disease , Stroke , substance-induced psychosis , T-cell non-Hodgkin lymphoma , type 2 diabetes mellitus , ureteral obstruction , urinary bladder cancer , Ventilator-Induced Lung Injury , Ventricular Remodeling , vulva cancer Akt2 adenocarcinoma , Breast Neoplasms , Carpenter Syndrome 2 , colorectal cancer , congenital hypoplastic anemia , craniosynostosis 1 , Diamond-Blackfan anemia , endometrial cancer , Experimental Mammary Neoplasms , familial partial lipodystrophy , genetic disease , hepatocellular carcinoma , high grade glioma , hypertension , hypoglycemia , hypoinsulinemic hypoglycemia with hemihypertrophy , Insulin Resistance , ischemia , malignant astrocytoma , maple syrup urine disease , maturity-onset diabetes of the young type 1 , Myocardial Reperfusion Injury , Neonatal Hypoglycemia, Simulating Foetopathia Diabetica , Neoplasm Metastasis , obesity , ovarian carcinoma , Ovarian Neoplasms , pancreatic cancer , polycystic ovary syndrome , prostate adenocarcinoma , prostate cancer , prostate carcinoma , Prostatic Neoplasms , Thyroid Neoplasms , type 2 diabetes mellitus Akt3 Bardet-Biedl syndrome , Bardet-Biedl syndrome 16 , capillary hemangioma , colon cancer , complex cortical dysplasia with other brain malformations , COVID-19 , developmental and epileptic encephalopathy 54 , Developmental Disabilities , gastrointestinal stromal tumor , genetic disease , glioblastoma , lung non-small cell carcinoma , Macrocephaly , malignant astrocytoma , megacolon , Megalencephaly - Cutis Marmorata Telangiectatica Congenita , Megalencephaly-Polymicrogyria-Polydactyly-Hydrocephalus Syndrome , Megalencephaly-Polymicrogyria-Polydactyly-Hydrocephalus Syndrome 2 , Neurodevelopmental Disorders , pancreatic adenocarcinoma , parathyroid carcinoma , polymicrogyria , prostate adenocarcinoma , prostate cancer , renal cell carcinoma , Senior-Loken syndrome , Senior-Loken Syndrome 7 Apc Abdominal Fibromatosis , Aberrant Crypt Foci , acinar cell carcinoma , adenocarcinoma , adenoma , Adenomatous Polyps , adult respiratory distress syndrome , Aggressive Fibromatosis , Alzheimer's disease , amenorrhea , anemia , Animal Mammary Neoplasms , ascending colon cancer , Attenuated Adenomatous Polyposis Coli , Attenuated Familial Adenomatous Polyposis , autism spectrum disorder , autistic disorder , breast cancer , Breast Cancer, Familial , breast carcinoma , cholangiocarcinoma , colon adenocarcinoma , colon cancer , colon carcinoma , Colonic Neoplasms , Colonic Polyps , colorectal adenoma , colorectal cancer , Colorectal Neoplasms , craniopharyngioma , desmoid tumor , Digestive System Neoplasms , duodenum adenocarcinoma , endometrial cancer , endometrial carcinoma , Endometrial Intraepithelial Neoplasia , Endometrial Neoplasms , Endometrioid Carcinomas , Eye Abnormalities , familial adenomatous polyposis , familial adenomatous polyposis 1 , familial hyperlipidemia , gallbladder cancer , Gallbladder Neoplasms , Gardner Syndrome , Gastric Adenocarcinoma and Proximal Polyposis of the Stomach , Gastric Polyposis , Gastrointestinal Hemorrhage , Gastrointestinal Neoplasms , gastrointestinal stromal tumor , glioblastoma , hepatoblastoma , hepatocellular carcinoma , hereditary breast ovarian cancer syndrome , hereditary desmoid disease , Hereditary Neoplastic Syndromes , high grade glioma , Hyperplasia , inflammatory bowel disease , intellectual disability , Intestinal Neoplasms , Intestinal Polyps , intrahepatic cholangiocarcinoma , Jaw Neoplasms , kidney disease , Klatskin's tumor , Leukocytosis , liver disease , Liver Neoplasms , lung adenocarcinoma , Lung Neoplasms , lung non-small cell carcinoma , Lynch syndrome , macrocytic anemia , medulloblastoma , Mesothelioma , mismatch repair cancer syndrome , Monoclonal B-Cell Lymphocytosis , Neoplastic Cell Transformation , Neurodevelopmental Disorders , ovarian cancer , pancreatic cancer , periampullary adenoma , prostate cancer , Prostatic Neoplasms , rectal benign neoplasm , rectum adenocarcinoma , renal cell carcinoma , sigmoid colon cancer , sigmoid neoplasm , splenic disease , Splenomegaly , squamous cell carcinoma , stomach cancer , Stomach Neoplasms , transitional cell carcinoma , Weight Loss Apc2 alcohol use disorder , autosomal recessive intellectual developmental disorder 74 , Breast Neoplasms , cerebral creatine deficiency syndrome , Colorectal Neoplasms , Complex Cortical Dysplasia with Other Brain Malformations 10 , cyclic hematopoiesis , epilepsy , genetic disease , inflammatory bowel disease , Neurodevelopmental Disorders , nicotine dependence , progressive myoclonus epilepsy 9 , Sotos syndrome 3 , Tracheoesophageal Fistula Appl1 Experimental Liver Cirrhosis , maturity-onset diabetes of the young type 14 , Pyruvate Dehydrogenase E1-Beta Deficiency , septooptic dysplasia Axin1 Caudal Duplication Anomaly , colon cancer , Colorectal Neoplasms , CRANIOMETADIAPHYSEAL OSTEOSCLEROSIS WITH HIP DYSPLASIA , epilepsy , esophagus squamous cell carcinoma , hepatocellular carcinoma , idiopathic generalized epilepsy , liver cirrhosis , lung cancer , lung non-small cell carcinoma , oral squamous cell carcinoma , short-rib thoracic dysplasia 9 with or without polydactyly , urinary bladder cancer Axin2 Animal Disease Models , anodontia , autosomal recessive limb-girdle muscular dystrophy type 2J , breast cancer , colon adenoma , colon carcinoma , Colonic Neoplasms , colorectal cancer , colorectal carcinoma , Colorectal Neoplasms , craniosynostosis , Craniosynostosis Syndrome, Autosomal Recessive , dilated cardiomyopathy , endometrial adenocarcinoma , familial adenomatous polyposis , gallbladder cancer , hepatoblastoma , hepatocellular carcinoma , Hereditary Neoplastic Syndromes , Hirschsprung's disease , Intestinal Polyps , lung adenocarcinoma , lung cancer , lung small cell carcinoma , Metaplasia , Myocardial Ischemia , Oligodontia-Colorectal Cancer Syndrome , oral mucosa leukoplakia , oral squamous cell carcinoma , orofacial cleft , ovarian cancer , Parkinson's disease , Pulmonary Arterial Hypertension , short-rib thoracic dysplasia 6 with or without polydactyly , tooth agenesis , transient cerebral ischemia , Ventilator-Induced Lung Injury , Ventricular Remodeling Bad acute kidney failure , Alzheimer's disease , amyotrophic lateral sclerosis , Brain Injuries , brain ischemia , breast cancer , Burns , Cardiomegaly , Chemical and Drug Induced Liver Injury , Chronic Pancreatitis , colon cancer , Diabetic Cardiomyopathies , Diabetic Cystopathy , diabetic neuropathy , endometrial cancer , Experimental Diabetes Mellitus , Experimental Mammary Neoplasms , Experimental Seizures , gastric ulcer , glaucoma , Hemorrhagic Shock , high grade glioma , hypertension , hypothyroidism , impotence , Insulin Resistance , intellectual disability , intermittent claudication , leukemia , leukocyte adhesion deficiency 3 , Liver Reperfusion Injury , lung non-small cell carcinoma , macular degeneration , middle cerebral artery infarction , morphine withdrawal syndrome , multiple endocrine neoplasia type 1 , Myocardial Reperfusion Injury , obesity , osteoarthritis , pancreatic cancer , Parkinsonism , prostate carcinoma , prostatic hypertrophy , Prostatic Neoplasms , pulmonary fibrosis , renal cell carcinoma , Reperfusion Injury , Retina Reperfusion Injury , Sepsis , Small-For-Size Syndrome , Spinal Cord Reperfusion Injury , transient cerebral ischemia , Transplant Rejection , traumatic brain injury , type 2 diabetes mellitus Bax abdominal obesity-metabolic syndrome 1 , acute kidney failure , Acute Lung Injury , acute lymphoblastic leukemia , acute myocardial infarction , Adrenal Insufficiency , Alzheimer's disease , amyotrophic lateral sclerosis , anti-basement membrane glomerulonephritis , ataxia telangiectasia , brain glioma , Brain Hypoxia-Ischemia , Brain Injuries , breast cancer , Breast Neoplasms , bronchopulmonary dysplasia , Burns , Cerebral Hemorrhage , cervical squamous cell carcinoma , Chemical and Drug Induced Liver Injury , Chronic Intermittent Hypoxia , clear cell renal cell carcinoma , colon adenocarcinoma , colon carcinoma , Colonic Neoplasms , colorectal cancer , Colorectal Neoplasms , congestive heart failure , dementia , depressive disorder , Diabetic Cardiomyopathies , dilated cardiomyopathy , endometriosis , Endotoxemia , Esophageal Neoplasms , Experimental Arthritis , Experimental Diabetes Mellitus , Experimental Mammary Neoplasms , Fetal Growth Retardation , Gastrointestinal Hemorrhage , genetic disease , glaucoma , heart disease , hepatocellular carcinoma , human immunodeficiency virus infectious disease , Huntington's disease , Hyperplasia , hypertension , impotence , intermittent claudication , intestinal disease , Intestinal Neoplasms , ischemia , Kashin-Beck Disease , Kidney Reperfusion Injury , Knee Osteoarthritis , leiomyoma , Liver Reperfusion Injury , Lung Injury , lung non-small cell carcinoma , Lung Reperfusion Injury , macular degeneration , male infertility , Microsatellite Instability , middle cerebral artery infarction , morphine dependence , Multi-Infarct Dementia , myocardial infarction , Myocardial Ischemia , Myocardial Reperfusion Injury , Neoplasm Metastasis , Nerve Degeneration , Optic Nerve Injuries , osteoarthritis , osteoporosis , polycystic ovary syndrome , post-traumatic stress disorder , pre-malignant neoplasm , Premature Aging , primary cutaneous T-cell non-Hodgkin lymphoma , prion disease , prostate cancer , prostate carcinoma , Prostatic Neoplasms , Reperfusion Injury , Retina Reperfusion Injury , retinal degeneration , rheumatic heart disease , Right Ventricular Hypertrophy , Sarcopenia , scrapie , Spinal Cord Injuries , status epilepticus , stomach cancer , T-cell acute lymphoblastic leukemia , teratoma , Testis Reperfusion Injury , thyroiditis , toxoplasmosis , transient cerebral ischemia , Transplant Rejection , type 2 diabetes mellitus , urinary bladder cancer , Ventricular Remodeling Bcl2 abdominal obesity-metabolic syndrome 1 , acute kidney failure , Acute Lung Injury , acute lymphoblastic leukemia , acute myeloid leukemia , adenocarcinoma , adenoma , Adrenal Insufficiency , AIDS-Related Kaposi Sarcoma , alcoholic liver cirrhosis , allergic contact dermatitis , allergic rhinitis , Alzheimer's disease , amyotrophic lateral sclerosis , anti-basement membrane glomerulonephritis , asthma , atherosclerosis , autistic disorder , azoospermia , B-Cell Chronic Lymphocytic Leukemia , bilirubin metabolic disorder , brain glioma , Brain Hypoxia-Ischemia , Brain Injuries , brain ischemia , Breast Neoplasms , Burns , carcinoma , Cerebral Hemorrhage , cervix uteri carcinoma in situ , chromosome 18q deletion syndrome , Chronic Intermittent Hypoxia , clear cell adenocarcinoma , colon adenocarcinoma , colon cancer , Colonic Neoplasms , Colorectal Neoplasms , congestive heart failure , contact dermatitis , dementia , Diabetic Cardiomyopathies , diffuse large B-cell lymphoma , dilated cardiomyopathy , Disease Progression , ductal carcinoma in situ , end stage renal disease , Endometrial Neoplasms , endometriosis , Endotoxemia , Esophageal Neoplasms , esophagus adenocarcinoma , Experimental Allergic Asthma , Experimental Arthritis , Experimental Colitis , Experimental Diabetes Mellitus , Experimental Liver Cirrhosis , Experimental Liver Neoplasms , Experimental Mammary Neoplasms , Familial Prostate Cancer , Fetal Growth Retardation , follicular lymphoma , Gallbladder Neoplasms , gastric ulcer , glaucoma , Head and Neck Neoplasms , Hemorrhagic Shock , hepatocellular carcinoma , Huntington's disease , hypertension , hypertrophic cardiomyopathy , Hypothermia , impotence , intestinal disease , Intestinal Neoplasms , intracranial aneurysm , Kashin-Beck Disease , Kidney Reperfusion Injury , Knee Osteoarthritis , learning disability , leiomyoma , Liver Reperfusion Injury , Lung Injury , Lung Reperfusion Injury , lung small cell carcinoma , Lymphatic Metastasis , male infertility , malignant mesothelioma , melanoma , Memory Disorders , mesenchymal chondrosarcoma , Metaplasia , middle cerebral artery infarction , morphine dependence , Multi-Infarct Dementia , multiple congenital anomalies-hypotonia-seizures syndrome 1 , multiple myeloma , myocardial infarction , Myocardial Ischemia , Myocardial Reperfusion Injury , nasopharynx carcinoma , Necrosis , Neoplasm Metastasis , Neoplastic Cell Transformation , Nerve Degeneration , non-Hodgkin lymphoma , obesity , oligomeganephronia , Optic Nerve Injuries , oral mucosa leukoplakia , osteoarthritis , osteochondrodysplasia , osteoporosis , Ovarian Neoplasms , Oxygen-Induced Retinopathy , plasmacytoma , polycystic ovary syndrome , post-traumatic stress disorder , Premature Aging , priapism , prostate cancer , Prostatic Neoplasms , pulmonary hypertension , renal cell carcinoma , Reperfusion Injury , Retina Reperfusion Injury , retinal degeneration , Sarcopenia , Soft Tissue Neoplasms , Spinal Cord Injuries , squamous cell carcinoma , status epilepticus , stomach cancer , Subarachnoid Hemorrhage , synovial sarcoma , T-cell acute lymphoblastic leukemia , Testis Reperfusion Injury , Tongue Neoplasms , tongue squamous cell carcinoma , transient cerebral ischemia , transitional cell carcinoma , Transplant Rejection , type 2 diabetes mellitus , urinary bladder cancer , Ventricular Remodeling , Viral Bronchiolitis Birc5 acute megakaryocytic leukemia , acute necrotizing pancreatitis , acute pancreatitis , acute promyelocytic leukemia , adenocarcinoma , adrenocortical carcinoma , adult T-cell leukemia/lymphoma , bladder urothelial carcinoma , brain glioma , Brain Injuries , breast carcinoma , Breast Neoplasms , chromophobe renal cell carcinoma , chronic myeloid leukemia , clear cell renal cell carcinoma , Colonic Neoplasms , colorectal cancer , Colorectal Neoplasms , congestive heart failure , COVID-19 , ductal carcinoma in situ , endometrial hyperplasia , Endometrial Neoplasms , Endometrioid Carcinomas , endometriosis , Experimental Liver Cirrhosis , Experimental Liver Neoplasms , Germ Cell and Embryonal Neoplasms , hepatocellular carcinoma , high grade glioma , idiopathic generalized epilepsy , Kidney Neoplasms , lung adenocarcinoma , Lung Neoplasms , lung non-small cell carcinoma , lung squamous cell carcinoma , Lymphatic Metastasis , malignant pleural mesothelioma , Mesothelioma , myocardial infarction , oral squamous cell carcinoma , Ovarian Neoplasms , pancreatic adenocarcinoma , papillary renal cell carcinoma , prostate cancer , Prostatic Neoplasms , pulmonary hypertension , Refractory Anemia , Refractory Anemia with Excess of Blasts , renal cell carcinoma , Reperfusion Injury , small cell carcinoma , squamous cell carcinoma , stomach carcinoma , Stomach Neoplasms , Testicular Germ Cell Tumor , thymoma , thyroid gland carcinoma , transitional cell carcinoma , urinary bladder cancer , Urologic Neoplasms , Uterine Cervical Neoplasms Braf adrenocortical carcinoma , ameloblastoma , Aortic Aneurysm, Giant Congenital , arteriovenous malformations of the brain , ataxia telangiectasia , bile duct adenoma , Breast Neoplasms , cancer , Carcinogenesis , cardiofaciocutaneous syndrome , cardiofaciocutaneous syndrome 1 , cardiomyopathy , cholangiocarcinoma , colon carcinoma , colorectal adenocarcinoma , colorectal cancer , Colorectal Neoplasms , Costello syndrome , craniopharyngioma , Dandy-Walker syndrome , Developmental Disabilities , diffuse large B-cell lymphoma , dilated cardiomyopathy , dysembryoplastic neuroepithelial tumor , dysplastic nevus syndrome , endometrial carcinoma , Experimental Melanoma , Experimental Neoplasms , familial melanoma , Follicular Thyroid Cancer , gallbladder cancer , ganglioglioma , gastric adenocarcinoma , gastrointestinal stromal tumor , genetic disease , germinoma , head and neck squamous cell carcinoma , hepatocellular carcinoma , high grade glioma , hypertrophic cardiomyopathy , hypertrophic cardiomyopathy 4 , intellectual disability , intrahepatic cholangiocarcinoma , Kidney Neoplasms , Langerhans-cell histiocytosis , Leber congenital amaurosis , Liver Metastasis , Liver Neoplasms , long QT syndrome , long QT syndrome 1 , lung adenocarcinoma , lung cancer , lung carcinoma , Lung Neoplasms , lung non-small cell carcinoma , lung squamous cell carcinoma , lymphangioma , Lymphatic Metastasis , malignant astrocytoma , Mandibular Neoplasms , melanoma , Microsatellite Instability , multiple myeloma , myoepithelioma , Neoplasm Metastasis , nephroblastoma , neuroendocrine tumor , Nevus , newborn respiratory distress syndrome , non-Hodgkin lymphoma , Nonseminomatous Germ Cell Tumor , Noonan syndrome , Noonan syndrome 1 , Noonan syndrome 7 , Noonan syndrome with multiple lentigines , Noonan syndrome with multiple lentigines 3 , Ovarian Neoplasms , pancreatic acinar cell adenocarcinoma , pancreatic cancer , papillary renal cell carcinoma , papillary thyroid carcinoma , Paraproteinemias , PHACE Association , plasma cell neoplasm , pleomorphic xanthoastrocytoma , Premature Birth , primary cutaneous T-cell non-Hodgkin lymphoma , prostate adenocarcinoma , Prostate Cancer, Hereditary, 1 , Prostatic Neoplasms , pulmonary valve stenosis , RASopathy , Romano-Ward Syndrome , Sengers syndrome , Sezary's disease , skin melanoma , tethered spinal cord syndrome , Thyroid Neoplasms , transitional cell carcinoma , type 2 diabetes mellitus , Vascular Malformations , ventricular septal defect Casp3 abdominal aortic aneurysm , Acute Liver Failure , Acute Lung Injury , acute myocardial infarction , acute necrotizing pancreatitis , Alzheimer's disease , amyotrophic lateral sclerosis , atherosclerosis , bacterial infectious disease , Brain Contusion , brain glioma , Brain Hypoxia-Ischemia , Brain Injuries , brain ischemia , breast cancer , breast carcinoma , bronchopulmonary dysplasia , Burns , calcinosis , cataract , Cerebral Hemorrhage , cervical cancer , chemical colitis , Chronic Hepatitis , chronic obstructive pulmonary disease , colon cancer , Colonic Neoplasms , congestive heart failure , Contrast-Induced Nephropathy , Copper-Overload Cirrhosis , cryptorchidism , diabetes mellitus , diabetic angiopathy , Diabetic Cardiomyopathies , Diabetic Nephropathies , diabetic neuropathy , diabetic retinopathy , dilated cardiomyopathy , Edema , endometritis , Endotoxemia , Experimental Autoimmune Encephalomyelitis , Experimental Autoimmune Myocarditis , Experimental Diabetes Mellitus , Experimental Mammary Neoplasms , Experimental Radiation Injuries , Fetal Growth Retardation , gastric ulcer , heart disease , heart valve disease , Hemorrhagic Shock , hepatocellular carcinoma , Huntington's disease , Hypercholesterolemia , hypertension , hypertrophic cardiomyopathy , Hypoxia , impotence , Insulin Resistance , intermittent claudication , intestinal disease , Intestinal Reperfusion Injury , kidney disease , Kidney Reperfusion Injury , liver cirrhosis , Liver Reperfusion Injury , lung non-small cell carcinoma , Lung Reperfusion Injury , middle cerebral artery infarction , Mycoplasma Infections , myocardial infarction , Myocardial Reperfusion Injury , Neoplasm Metastasis , Nerve Degeneration , nervous system disease , osteoarthritis , Osteoarthritis, Experimental , Oxygen-Induced Retinopathy , pancreatitis , Parkinson's disease , Parkinsonism , pre-malignant neoplasm , prostate cancer , Prostatic Neoplasms , renal cell carcinoma , Reperfusion Injury , retinal detachment , retinal disease , salivary gland disease , sciatic neuropathy , scrapie , Sepsis , severe acute respiratory syndrome , spermatic cord torsion , Spinal Cord Injuries , status epilepticus , stomach cancer , Stroke , Subarachnoid Hemorrhage , Testis Reperfusion Injury , toxic encephalopathy , transient cerebral ischemia , transitional cell carcinoma , Transplant Rejection , traumatic brain injury , type 1 diabetes mellitus , type 2 diabetes mellitus , ulcerative colitis , ureteral obstruction , urinary bladder cancer , Ventricular Remodeling , Viral Myocarditis Casp9 Acute Liver Failure , Alzheimer's disease , amyotrophic lateral sclerosis , bacterial infectious disease , Brain Hypoxia-Ischemia , brain ischemia , breast cancer , bronchopulmonary dysplasia , cataract , Cerebral Hemorrhage , chromosome 1p36 deletion syndrome , colorectal cancer , Diabetes Complications , Diabetic Cardiomyopathies , Diabetic Nephropathies , diabetic retinopathy , dilated cardiomyopathy , Edema , endometritis , Endotoxemia , Experimental Autoimmune Encephalomyelitis , Experimental Autoimmune Myocarditis , Experimental Diabetes Mellitus , Experimental Mammary Neoplasms , Experimental Radiation Injuries , focal segmental glomerulosclerosis , heart disease , hepatocellular carcinoma , Hereditary Pancreatitis , Huntington's disease , Hypercholesterolemia , hypertension , Intestinal Reperfusion Injury , kidney disease , liver cirrhosis , Liver Reperfusion Injury , lung non-small cell carcinoma , Lymphatic Metastasis , middle cerebral artery infarction , Myocardial Reperfusion Injury , nervous system disease , NSAID-Enteropathy , osteoarthritis , pancreatic cancer , Parkinson's disease , Parkinsonism , peripheral nervous system disease , post-traumatic stress disorder , pre-malignant neoplasm , Prostatic Neoplasms , Reperfusion Injury , retinal detachment , scrapie , Sepsis , severe acute respiratory syndrome , Spinal Cord Injuries , stomach cancer , Subarachnoid Hemorrhage , Testis Reperfusion Injury , transient cerebral ischemia , traumatic brain injury , type 1 diabetes mellitus , type 2 diabetes mellitus , ureteral obstruction , urinary bladder cancer , varicocele Ccnd1 acute lymphoblastic leukemia , acute myeloid leukemia , adenocarcinoma , adenoid cystic carcinoma , Aicardi-Goutieres Syndrome 3 , angiosarcoma , Animal Mammary Neoplasms , atherosclerosis , B-lymphoblastic leukemia/lymphoma , Bowen's Disease , Brain Neoplasms , Breast Neoplasms , bronchiolo-alveolar adenocarcinoma , Burns , carcinoma , Cecal Neoplasms , cervix uteri carcinoma in situ , Chronic Hepatitis C , colon adenoma , Colonic Neoplasms , colorectal cancer , Colorectal Neoplasms , Disease Progression , ductal carcinoma in situ , Endometrial Neoplasms , Esophageal Neoplasms , esophagus squamous cell carcinoma , Experimental Liver Neoplasms , Experimental Mammary Neoplasms , Experimental Neoplasms , Experimental Seizures , Genomic Instability , head and neck squamous cell carcinoma , hepatocellular carcinoma , high grade glioma , hyperparathyroidism , Hyperplasia , impotence , intellectual disability , interstitial cystitis , Intestinal Polyps , invasive lobular carcinoma , Kidney Neoplasms , leukemia , liver cancer , Liver Neoplasms , long QT syndrome , lung adenocarcinoma , Lung Neoplasms , lung non-small cell carcinoma , lung small cell carcinoma , lung squamous cell carcinoma , malignant astrocytoma , mantle cell lymphoma , medulloblastoma , multiple myeloma , Myocardial Ischemia , Nasopharyngeal Neoplasms , Neoplasm Metastasis , Neoplastic Cell Transformation , non-Hodgkin lymphoma , ovarian carcinoma , pancreatic adenocarcinoma , pancreatic cancer , pancreatic ductal adenocarcinoma , pancreatic ductal carcinoma , Pancreatic Intraepithelial Neoplasia , pancreatic solid pseudopapillary carcinoma , papillary thyroid carcinoma , papilloma , penile benign neoplasm , pre-malignant neoplasm , prostate cancer , prostate carcinoma in situ , Prostatic Neoplasms , Recurrent Infections, with Encephalopathy, Hepatic Dysfunction, and Cardiovascular Malformations , renal cell carcinoma , Reperfusion Injury , Salivary Gland Neoplasms , squamous cell carcinoma , status epilepticus , Stomach Neoplasms , Thyroid Neoplasms , tongue squamous cell carcinoma , transitional cell carcinoma , urinary bladder cancer , Urologic Neoplasms , Uterine Cervical Neoplasms , von Hippel-Lindau disease Ctnnb1 Aberrant Crypt Foci , adenocarcinoma , adenoma , Adrenal Cortex Neoplasms , Adrenal Gland Neoplasms , adrenocortical carcinoma , Alazami Syndrome , Alzheimer's disease , Angiofibroma , angiosarcoma , Animal Disease Models , atherosclerosis , autism spectrum disorder , autosomal dominant intellectual developmental disorder 19 , Breast Neoplasms , calcinosis , Cecal Neoplasms , Chemical and Drug Induced Liver Injury , colon adenocarcinoma , colon carcinoma , Colonic Neoplasms , colorectal cancer , Colorectal Neoplasms , congenital muscular dystrophy-dystroglycanopathy type A8 , Craniofacial Abnormalities , craniopharyngioma , desmoid tumor , Developmental Disabilities , Developmental Disease , Diabetic Cardiomyopathies , dilated cardiomyopathy , Disease Progression , endodermal sinus tumor , Endometrial Intraepithelial Neoplasia , Endometrial Neoplasms , Endometrioid Carcinomas , endometriosis , Experimental Liver Neoplasms , Experimental Mammary Neoplasms , Experimental Neoplasms , exudative vitreoretinopathy , exudative vitreoretinopathy 1 , exudative vitreoretinopathy 7 , fibrolamellar carcinoma , Fibrosis , gallbladder cancer , genetic disease , granulosa cell tumor , head and neck squamous cell carcinoma , hepatitis B , hepatoblastoma , hepatocellular adenoma , hepatocellular carcinoma , hereditary desmoid disease , heroin dependence , hyperekplexia , hypertrophic cardiomyopathy , imperforate anus , in situ carcinoma , intellectual disability , Intestinal Neoplasms , invasive lobular carcinoma , Knee Osteoarthritis , Left Ventricular Hypertrophy , liver cirrhosis , Liver Neoplasms , lung adenocarcinoma , lung cancer , lung carcinoma , Lung Neoplasms , lung squamous cell carcinoma , Lymphatic Metastasis , malignant mesothelioma , Mandibular Neoplasms , mantle cell lymphoma , medulloblastoma , Metaplasia , Multiple Abnormalities , muscular atrophy , Myocardial Ischemia , Neoplasm Invasiveness , Neoplasm Metastasis , Neoplastic Cell Transformation , nephroblastoma , Nerve Degeneration , Nervous System Malformations , Neurodevelopmental Disorders , No-Reflow Phenomenon , osteosclerosis , ovarian cancer , Ovarian Neoplasms , pancreatic cancer , papillary thyroid carcinoma , Peritoneal Neoplasms , Phyllodes Tumor , pilomatrixoma , polycystic liver disease , polycystic liver disease 1 , progressive osseous heteroplasia , prostate adenocarcinoma , prostate cancer , Prostatic Neoplasms , Recurrence , renal cell carcinoma , Renal Cell Carcinoma 1 , skin melanoma , Skin Neoplasms , Stevens-Johnson syndrome , Stiff-Person syndrome , stomach cancer , Stroke , teratoma , Thyroid Neoplasms , transitional cell carcinoma , traumatic brain injury , urinary bladder cancer , Uterine Cervical Neoplasms , Uterine Neoplasms , Vascular Calcification , Ventricular Dysfunction, Left , Ventricular Remodeling Cycs brain ischemia , Chloracne , cholangiocarcinoma , hemorrhagic disease , Huntington's disease , ischemia , lung non-small cell carcinoma , lung squamous cell carcinoma , Lymphatic Metastasis , methylmalonic acidemia , Neoplasm Micrometastasis , obesity , pancreatic cancer , pleomorphic xanthoastrocytoma , steatotic liver disease , thrombocytopenia , Thrombocytopenia 4 , transient cerebral ischemia Dcc Agenesis of Corpus Callosum , amenorrhea , autism spectrum disorder , bone marrow disease , colon carcinoma , colorectal cancer , Colorectal Neoplasms , esophageal cancer , esophageal carcinoma , Esophageal Neoplasms , esophagus squamous cell carcinoma , Experimental Autoimmune Neuritis , Familial Horizontal Gaze Palsy with Progressive Scoliosis , Familial Horizontal Gaze Palsy with Progressive Scoliosis, 2 , genetic disease , intellectual disability , melanoma , Mirror Movements 1 , Partial Agenesis of Corpus Callosum , Reperfusion Injury , Spinal Cord Injuries Fos Aberrant Crypt Foci , acute myocardial infarction , alcohol dependence , alcohol use disorder , alcohol withdrawal syndrome , Alcohol-Related Disorders , Alcoholic Intoxication , amphetamine abuse , amyotrophic lateral sclerosis type 1 , Animal Disease Models , anxiety disorder , autosomal dominant polycystic kidney disease , Binge Drinking , Brain Hypoxia-Ischemia , Brain Injuries , Breast Neoplasms , cervical squamous cell carcinoma , cocaine abuse , cocaine dependence , Cocaine-Related Disorders , Colonic Neoplasms , colorectal adenocarcinoma , colorectal adenoma , Colorectal Neoplasms , congenital hypothyroidism , congestive heart failure , degenerative disc disease , depressive disorder , endometriosis , epilepsy , Experimental Arthritis , Experimental Liver Cirrhosis , extrahepatic cholestasis , Fetal Growth Retardation , Fibrous Dysplasia of Bone , functional diarrhea , gastric ulcer , glomerulonephritis , Heat Stroke , Hematuria , hemolytic-uremic syndrome , Hemorrhage , hepatocellular carcinoma , Hyperalgesia , Hyperkinesis , hypertension , hypospadias , Inhalant Abuse , intellectual disability , irritable bowel syndrome , juvenile rheumatoid arthritis , Kidney Reperfusion Injury , Lung Neoplasms , middle cerebral artery infarction , migraine , morphine dependence , morphine withdrawal syndrome , myocardial infarction , Neoplastic Cell Transformation , nervous system disease , nicotine dependence , Nociceptive Pain , obesity , ovarian carcinoma , Pick's disease , post-traumatic stress disorder , rectal benign neoplasm , Reperfusion Injury , sleeping sickness , status epilepticus , temporal lobe epilepsy , Tendon Injuries , Tongue Neoplasms , tongue squamous cell carcinoma , toxic encephalopathy , trigeminal neuralgia , Ventilator-Induced Lung Injury , Wernicke encephalopathy , withdrawal disorder Gsk3b Aberrant Crypt Foci , acute kidney failure , acute myocardial infarction , Alzheimer's disease , amyotrophic lateral sclerosis , bipolar disorder , Brain Injuries , Breast Neoplasms , Burns , Cardiomegaly , cognitive disorder , colon cancer , Colonic Neoplasms , colorectal adenocarcinoma , congestive heart failure , degenerative disc disease , depressive disorder , diabetic encephalopathy , Diabetic Nephropathies , dilated cardiomyopathy , Drug-Induced Dyskinesia , endometrial carcinoma , Endometrial Neoplasms , Experimental Arthritis , Experimental Mammary Neoplasms , Hearing Loss, Cisplatin-Induced , heart disease , hypertension , Intestinal Neoplasms , Liver Reperfusion Injury , mantle cell lymphoma , middle cerebral artery infarction , Multiple Abnormalities , muscular atrophy , myocardial infarction , Myocardial Reperfusion Injury , Neoplastic Cell Transformation , neuronal ceroid lipofuscinosis 6A , oral squamous cell carcinoma , Ovarian Neoplasms , Parkinson's disease , peritonitis , Poisoning , Prostatic Neoplasms , schizophrenia , sciatic neuropathy , Sepsis , status epilepticus , Subarachnoid Hemorrhage , substance-related disorder , Tachycardia , tauopathy , type 2 diabetes mellitus , urinary bladder cancer , vascular dementia Jun Alcohol-Related Disorders , angiosarcoma , Asphyxia , basal cell carcinoma , Brain Injuries , brain ischemia , breast cancer , Breast Neoplasms , chronic obstructive pulmonary disease , Colonic Neoplasms , colorectal adenocarcinoma , colorectal adenoma , COVID-19 , depressive disorder , endometrial adenocarcinoma , endometrial carcinoma , extrahepatic cholestasis , glaucoma , Heat Stroke , hepatocellular carcinoma , Hodgkin's lymphoma , hypertension , Intestinal Polyps , juvenile rheumatoid arthritis , Liver Neoplasms , Lung Neoplasms , Mercury Poisoning, Nervous System , Nasal Polyps , Neoplastic Cell Transformation , Optic Nerve Injuries , oral squamous cell carcinoma , osteopetrosis , osteosarcoma , peripheral nervous system disease , prostate adenocarcinoma , prostate carcinoma , Prostatic Neoplasms , pulmonary emphysema , pulmonary tuberculosis , renal carcinoma , renal cell carcinoma , Reperfusion Injury , silicosis , Spinal Cord Injuries , status epilepticus , Stomach Neoplasms , tongue squamous cell carcinoma Kras Acute Experimental Pancreatitis , acute lymphoblastic leukemia , acute myeloid leukemia , adenocarcinoma , adenoma , anaplastic astrocytoma , anemia , angiosarcoma , Animal Disease Models , arteriovenous malformations of the brain , autoimmune lymphoproliferative syndrome type 4 , breast adenocarcinoma , breast cancer , Breast Cancer, Familial , Breast Neoplasms , bronchiolo-alveolar adenocarcinoma , Capillary Malformation-Arteriovenous Malformation 1 , Carcinogenesis , carcinoma , cardiofaciocutaneous syndrome , cardiofaciocutaneous syndrome 1 , cardiofaciocutaneous syndrome 2 , cardiomyopathy , Cecal Neoplasms , cholangiocarcinoma , chronic myelogenous leukemia, BCR-ABL1 positive , Colonic Neoplasms , colorectal cancer , Colorectal Neoplasms , Costello syndrome , dilated cardiomyopathy , disease of cellular proliferation , Disease Progression , Encephalocraniocutaneous Lipomatosis , endometrial adenocarcinoma , endometrial carcinoma , endometrial hyperplasia , Endometrial Hyperplasia without Atypia , Endometrial Intraepithelial Neoplasia , Endometrial Neoplasms , Endometrioid Carcinomas , endometriosis , epidermal nevus , Experimental Liver Neoplasms , Experimental Neoplasms , Experimental Sarcoma , Familial Pancreatic Carcinoma , fibrillary astrocytoma , follicular thyroid carcinoma , gallbladder cancer , Gallbladder Neoplasms , gastrointestinal stromal tumor , genetic disease , glioblastoma , hepatocellular adenoma , hepatocellular carcinoma , hereditary breast ovarian cancer syndrome , hereditary diffuse gastric cancer , high grade glioma , Hodgkin's lymphoma , Hydrops Fetalis , hypertension , intellectual disability , intrahepatic cholangiocarcinoma , juvenile myelomonocytic leukemia , juvenile rheumatoid arthritis , Kidney Neoplasms , Klatskin's tumor , Leukocytosis , linear nevus sebaceous syndrome , Liver Neoplasms , lung adenocarcinoma , lung cancer , lung carcinoma , Lung Neoplasms , lung non-small cell carcinoma , Lung Reperfusion Injury , lung sarcomatoid carcinoma , lung squamous cell carcinoma , lymphoma , Lynch syndrome , malignant astrocytoma , Mouth Neoplasms , Multiple Abnormalities , multiple myeloma , muscular atrophy , myelodysplastic syndrome , myeloid neoplasm , myeloid sarcoma , Neoplasm Metastasis , Neoplastic Cell Transformation , neuroblastoma , Noonan syndrome , Noonan syndrome 1 , Noonan syndrome 3 , oculoectodermal syndrome , Ovarian Neoplasms , ovary serous adenocarcinoma , pancreatic cancer , pancreatic carcinoma , pancreatic ductal carcinoma , pancreatic mucinous cystadenoma , Paraproteinemias , Parasitic Liver Diseases , Penile Neoplasms , pilocytic astrocytoma , plasma cell neoplasm , prostate cancer , Prostate Cancer, Hereditary, 1 , prostate carcinoma in situ , Prostatic Neoplasms , RASopathy , Recurrence , renal cell carcinoma , renal fibrosis , Sebaceous Nevus Syndrome and Hemimegalencephaly , seminoma , Splenomegaly , squamous cell carcinoma , stomach cancer , stomach carcinoma , Stomach Neoplasms , T-cell acute lymphoblastic leukemia , teratoma , Thyroid Carcinoma, Nonmedullary 1 , Thyroid Neoplasms , transitional cell carcinoma , Triple Negative Breast Neoplasms , urinary bladder cancer , Urinary Bladder Neoplasm , Uterine Cervical Neoplasms , Uterine Neoplasms , Vascular Malformations Lef1 Animal Disease Models , B-Cell Chronic Lymphocytic Leukemia , basal cell carcinoma , Breast Neoplasms , Colonic Neoplasms , Congenital Limb Deformities , dilated cardiomyopathy , Femoral Fractures , Neoplasm Invasiveness , Neoplasm Metastasis , ovarian cancer , papillary thyroid carcinoma , prostate cancer , prostate carcinoma in situ , rheumatic heart disease , sebaceous gland neoplasm , split hand-foot malformation Map2k1 autism spectrum disorder , Bloom syndrome , brain ischemia , breast cancer , cardiofaciocutaneous syndrome , cardiofaciocutaneous syndrome 1 , cardiofaciocutaneous syndrome 3 , Cardiovascular Abnormalities , cataract , colorectal cancer , congestive heart failure , Costello syndrome , Experimental Liver Neoplasms , Familial Prostate Cancer , genetic disease , hairy cell leukemia , high grade glioma , lung adenocarcinoma , lung non-small cell carcinoma , lung squamous cell carcinoma , melanoma , melorheostosis , neuronal ceroid lipofuscinosis , Noonan syndrome , Noonan syndrome 1 , ovarian carcinoma , Ovarian Neoplasms , pancreatic adenocarcinoma , pancreatitis , prostate adenocarcinoma , Prostatic Neoplasms , RASopathy , renal cell carcinoma , small intestine adenocarcinoma , spermatogenic failure 57 , Sturge-Weber syndrome , Vascular Malformations Mapk1 Aberrant Crypt Foci , alcohol dependence , alcohol use disorder , Alzheimer's disease , Animal Disease Models , autism spectrum disorder , brain ischemia , breast cancer , Cardiomegaly , cardiomyopathy , childhood pilocytic astrocytoma , chromosome 22q11.2 deletion syndrome, distal , cocaine abuse , cocaine dependence , Cocaine-Related Disorders , colon adenocarcinoma , colon cancer , colorectal adenocarcinoma , Colorectal Neoplasms , congenital heart disease , coronary restenosis , Coronavirus infectious disease , demyelinating disease , depressive disorder , Diabetic Cardiomyopathies , Diabetic Nephropathies , DiGeorge syndrome , Dwarfism , endometrial adenocarcinoma , endometrial carcinoma , Endometrioid Carcinomas , Experimental Colitis , Experimental Diabetes Mellitus , Experimental Liver Cirrhosis , Experimental Liver Neoplasms , Experimental Mammary Neoplasms , Experimental Radiation Injuries , extrahepatic cholestasis , Female Infertility , gastric ulcer , genetic disease , Gliosis , glomerulonephritis , Head and Neck Neoplasms , Hemorrhagic Shock , hepatocellular carcinoma , Hodgkin's lymphoma , Hyperalgesia , Hypertrophy , intellectual disability , Intimal Hyperplasia , juvenile rheumatoid arthritis , kidney disease , Kidney Neoplasms , Left Ventricular Hypertrophy , Lung Neoplasms , melanoma , Memory Disorders , middle cerebral artery infarction , morphine dependence , Multiple Organ Failure , myocardial infarction , Myocardial Reperfusion Injury , Neoplasm Invasiveness , Neoplasm Metastasis , Nerve Degeneration , neuronal ceroid lipofuscinosis 6A , Noonan syndrome 13 , obesity , Ovarian Neoplasms , pancreatic adenocarcinoma , Parkinson's disease , Pneumococcal Pneumonia , portal hypertension , Postoperative Cognitive Dysfunction , prostate adenocarcinoma , pulmonary hypertension , renal cell carcinoma , renal fibrosis , Sepsis , severe acute respiratory syndrome , Sezary's disease , Shock , squamous cell carcinoma , Stomach Neoplasms , Testis Reperfusion Injury , thyroid cancer , Thyroid Neoplasms , trigeminal neuralgia , type 2 diabetes mellitus , ureteral obstruction , urethral obstruction , Urinary Incontinence , vascular dementia , velocardiofacial syndrome , Weissenbacher-Zweymuller syndrome , withdrawal disorder Mapk10 Alzheimer's disease , congestive heart failure , Generalized Epilepsy , Lennox-Gastaut syndrome , pancreatic adenocarcinoma , prostate cancer Mapk3 Aberrant Crypt Foci , alcohol dependence , alcohol use disorder , Alzheimer's disease , Animal Disease Models , Atrophy , autism spectrum disorder , autistic disorder , brain ischemia , cardiomyopathy , chromosome 16p11.2 deletion syndrome, 593-kb , chromosome 16p11.2 duplication syndrome , cocaine abuse , cocaine dependence , Cocaine-Related Disorders , colon adenocarcinoma , colorectal adenocarcinoma , Colorectal Neoplasms , Coronavirus infectious disease , coronin-1A deficiency , Developmental Disabilities , Diabetic Cardiomyopathies , dilated cardiomyopathy , endometrial adenocarcinoma , endometrial carcinoma , Endometrial Neoplasms , Endometrioid Carcinomas , Episodic Kinesigenic Dyskinesia , episodic kinesigenic dyskinesia 1 , Experimental Colitis , Experimental Diabetes Mellitus , Experimental Liver Cirrhosis , Experimental Liver Neoplasms , Experimental Mammary Neoplasms , Experimental Radiation Injuries , extrahepatic cholestasis , Female Infertility , gastric ulcer , Gliosis , Glycogen Storage Disease XII , Head and Neck Neoplasms , high grade glioma , Hyperalgesia , Hypertrophy , Insulin Resistance , Kidney Neoplasms , Lung Neoplasms , Memory Disorders , middle cerebral artery infarction , morphine dependence , Myocardial Reperfusion Injury , Neoplasm Invasiveness , Neoplasm Metastasis , Nerve Degeneration , Neurodevelopmental Disorders , neuronal ceroid lipofuscinosis 6A , obesity , Osteoarthritis, Experimental , Ovarian Neoplasms , pancreatic ductal carcinoma , Parkinson's disease , Pneumococcal Pneumonia , Postoperative Cognitive Dysfunction , Prostatic Neoplasms , pulmonary hypertension , schizophrenia , Sepsis , severe acute respiratory syndrome , Shock , spondylocostal dysostosis 5 , squamous cell carcinoma , Stomach Neoplasms , Testis Reperfusion Injury , trigeminal neuralgia , type 2 diabetes mellitus , ureteral obstruction , withdrawal disorder Mapk8 abdominal aortic aneurysm , Acute Liver Failure , Acute Otitis Media , alcohol use disorder , Alzheimer's disease , Animal Disease Models , anogenital venereal wart , anti-basement membrane glomerulonephritis , Arenaviridae infectious disease , atopic dermatitis , bacterial pneumonia , brain ischemia , candidiasis , Cardiomegaly , chronic mucocutaneous candidiasis , chronic obstructive pulmonary disease , Cockayne syndrome B , Colonic Neoplasms , colorectal adenocarcinoma , colorectal adenoma , Contrast-Induced Nephropathy , dengue disease , endometriosis , Endotoxemia , extrahepatic cholestasis , Helicobacter Infections , hepatitis , hepatocellular carcinoma , Hyperalgesia , hypertension , Infectious Ectromelia , influenza A , Intestinal Neoplasms , Kuhnt-Junius degeneration , Liver Reperfusion Injury , megacolon , metabolic dysfunction-associated steatotic liver disease , myocardial infarction , Myocardial Reperfusion Injury , Neoplastic Cell Transformation , Oxygen-Induced Retinopathy , pancreatic adenocarcinoma , pancreatic ductal adenocarcinoma , Parkinsonism , pre-malignant neoplasm , Pseudomonas Infections , rectal benign neoplasm , Reperfusion Injury , schizophrenia , Sepsis , steatotic liver disease , Stomach Neoplasms , Stroke , trigeminal neuralgia , type 2 diabetes mellitus Mapk9 Alzheimer's disease , Animal Disease Models , arteriosclerosis , colorectal cancer , extrahepatic cholestasis , hepatitis , Hyperalgesia , ischemia , Neoplasm Metastasis , pancreatic adenocarcinoma , pre-malignant neoplasm , Prostatic Neoplasms , Reperfusion Injury , trigeminal neuralgia , type 2 diabetes mellitus Mlh1 bile duct cancer , breast cancer , Breast Cancer, Familial , breast carcinoma , cervix uteri carcinoma in situ , colon cancer , colon carcinoma , Colonic Neoplasms , colorectal cancer , Colorectal Neoplasms , Developmental Disabilities , endometrial carcinoma , Endometrial Neoplasms , esophagus squamous cell carcinoma , Germ Cell and Embryonal Neoplasms , hereditary breast ovarian cancer syndrome , Hereditary Neoplastic Syndromes , hereditary nonpolyposis colorectal cancer type 2 , Hydatidiform Mole , hydrocephalus , Intestinal Polyps , laryngeal squamous cell carcinoma , lung adenocarcinoma , lung cancer , lung carcinoma , lung non-small cell carcinoma , lymphoma , Lynch syndrome , Lynch syndrome 1 , malignant pleural mesothelioma , mismatch repair cancer syndrome , Mismatch Repair Cancer Syndrome 1 , Muir-Torre syndrome , Multiple Primary Neoplasms , Neoplasm Metastasis , osteogenesis imperfecta , osteogenesis imperfecta type 1 , ovarian cancer , Ovarian Neoplasms , peritoneal carcinoma , Prostatic Neoplasms , renal cell carcinoma , sporadic breast cancer , squamous cell carcinoma , stomach cancer , urinary bladder cancer , Uterine Cervical Neoplasms , visceral heterotaxy 4 , Vulvar Neoplasms Msh2 ascending colon cancer , bile duct cancer , breast cancer , breast carcinoma , cervix uteri carcinoma in situ , colitis , colon cancer , colon carcinoma , Colon Diverticulum , Colonic Polyps , colorectal adenocarcinoma , colorectal cancer , Colorectal Neoplasms , Congenital Adrenal Hyperplasia due to 21 Hydroxylase Deficiency , endometrial carcinoma , Endometrial Neoplasms , esophagus squamous cell carcinoma , Experimental Seizures , Germ Cell and Embryonal Neoplasms , glioblastoma , hepatoblastoma , hereditary breast ovarian cancer syndrome , Hereditary Neoplastic Syndromes , hereditary nonpolyposis colorectal cancer type 2 , hereditary nonpolyposis colorectal cancer type 4 , high grade glioma , Huntington's disease , Hydatidiform Mole , Hydatidiform Mole, Invasive , laryngeal squamous cell carcinoma , lung adenocarcinoma , lung cancer , lung non-small cell carcinoma , Lymphatic Metastasis , Lynch syndrome , Lynch syndrome 1 , mismatch repair cancer syndrome , Mismatch Repair Cancer Syndrome 1 , Mismatch Repair Cancer Syndrome 2 , Muir-Torre syndrome , Neoplasm Metastasis , osteosarcoma , ovarian cancer , ovarian cyst , Ovarian Neoplasms , Pitt-Hopkins-like syndrome 2 , prostate cancer , renal cell carcinoma , Renal Cell Carcinoma 1 , rhabdomyosarcoma , sarcoma , sigmoid colon cancer , sigmoid neoplasm , stomach cancer , transitional cell carcinoma , urinary bladder cancer , Urogenital Neoplasms , Uterine Cervical Neoplasms , uterine corpus cancer , Vulvar Neoplasms Msh3 colorectal carcinoma , Digestive System Neoplasms , endometrial cancer , endometrial carcinoma , Endometrial Neoplasms , familial adenomatous polyposis , familial adenomatous polyposis 4 , gastrointestinal stromal tumor , hepatocellular carcinoma , Hereditary Neoplastic Syndromes , lung adenocarcinoma , lung cancer , lung non-small cell carcinoma , Megaloblastic Anemia due to Dihydrofolate Reductase Deficiency , Microsatellite Instability , Neurodevelopmental Disorders , Prostatic Neoplasms Msh6 ataxia telangiectasia , autosomal recessive limb-girdle muscular dystrophy type 2B , B-lymphoblastic leukemia/lymphoma with BCR-ABL1 , bilateral breast cancer , breast cancer , Breast Cancer, Familial , breast carcinoma , cerebellar medulloblastoma , colon adenocarcinoma , colon carcinoma , colorectal cancer , colorectal carcinoma , Colorectal Neoplasms , Digestive System Neoplasms , endometrial cancer , endometrial carcinoma , Endometrial Neoplasms , endometrial serous adenocarcinoma , Familial Prostate Cancer , Gaucher's disease , Gaucher's disease type I , genetic disease , Genetic Predisposition to Disease , GM1 gangliosidosis , GM1 gangliosidosis type 1 , hepatoblastoma , hereditary breast ovarian cancer syndrome , Hereditary Neoplastic Syndromes , hereditary nonpolyposis colorectal cancer type 4 , hereditary nonpolyposis colorectal cancer type 5 , INTELLECTUAL DEVELOPMENTAL DISORDER WITH DYSMORPHIC FACIES AND BEHAVIORAL ABNORMALITIES , Joubert syndrome 9 , lung adenocarcinoma , lung sarcomatoid carcinoma , Lynch syndrome , Lynch syndrome 1 , Microsatellite Instability , mismatch repair cancer syndrome , Mismatch Repair Cancer Syndrome 1 , Mismatch Repair Cancer Syndrome 3 , Neurodevelopmental Disorders , osteosarcoma , ovarian cancer , ovarian carcinoma , Ovarian Neoplasms , Pitt-Hopkins-like syndrome 2 , prostate cancer , rhabdomyosarcoma , sigmoid colon cancer , sigmoid neoplasm , stomach cancer , Thyroid Neoplasms , urinary bladder cancer , Urogenital Neoplasms , uterine corpus cancer , xeroderma pigmentosum group D Myc Aberrant Crypt Foci , acute kidney failure , acute lymphoblastic leukemia , acute myeloid leukemia , acute promyelocytic leukemia , adenocarcinoma , Alcoholic Liver Diseases , angiosarcoma , Animal Disease Models , atherosclerosis , autosomal dominant polycystic kidney disease , autosomal recessive polycystic kidney disease , B-lymphoblastic leukemia/lymphoma , breast cancer , Breast Neoplasms , Burkitt lymphoma , carcinoma , Cardiomegaly , Carotid Artery Injuries , cholesteatoma of middle ear , Chromosome Breakage , chronic lymphocytic leukemia , clear cell renal cell carcinoma , cleft lip , cleft palate , Colonic Neoplasms , Colorectal Neoplasms , coronary restenosis , COVID-19 , demyelinating disease , diffuse large B-cell lymphoma , disease of cellular proliferation , Disease Progression , Ductal Carcinoma , Endometrial Neoplasms , Esophageal Neoplasms , Experimental Diabetes Mellitus , Experimental Liver Cirrhosis , Experimental Liver Neoplasms , Experimental Mammary Neoplasms , glioblastoma , Hemorrhagic Shock , hepatitis C , hepatocellular carcinoma , Hodgkin's lymphoma , hyperparathyroidism , hypertrophic cardiomyopathy , Kidney Reperfusion Injury , Left Ventricular Hypertrophy , leiomyoma , liver cirrhosis , Liver Injury , Liver Neoplasms , lung adenocarcinoma , lung cancer , Lung Neoplasms , lung non-small cell carcinoma , Lung Reperfusion Injury , lung small cell carcinoma , medulloblastoma , Merkel cell carcinoma , myelodysplastic syndrome , Neoplasm Metastasis , Neoplastic Cell Transformation , nephroblastoma , neuroblastoma , neuroectodermal tumor , obesity , osteoporosis , osteosarcoma , Ovarian Neoplasms , pancreatic cancer , pancreatic carcinoma , papillary thyroid carcinoma , polycystic kidney disease , polycystic kidney disease 1 , primary ovarian insufficiency , prolactinoma , prostate adenocarcinoma , prostate cancer , prostate carcinoma in situ , prostatic hypertrophy , Prostatic Neoplasms , pulmonary hypertension , renal cell carcinoma , renal fibrosis , rhabdoid cancer , Sporadic Papillary Renal Cell Carcinoma , squamous cell carcinoma , steatotic liver disease , Stomach Neoplasms , thyroid cancer , Transplant Rejection , trichorhinophalangeal syndrome type I , urinary bladder cancer , Uterine Cervical Neoplasms Pik3ca adenocarcinoma , adenoid cystic carcinoma , Agenesis of Corpus Callosum , arteriovenous malformation , autosomal recessive polycystic kidney disease , Bannayan-Riley-Ruvalcaba syndrome , basal cell carcinoma , Brain Neoplasms , breast adenocarcinoma , breast angiosarcoma , breast cancer , Breast Cancer, Familial , breast carcinoma , Breast Neoplasms , Capillary Malformation-Arteriovenous Malformation 1 , Cardiovascular Abnormalities , Cerebral Cavernous Malformation 4 , CLAPO Syndrome , CLOVES syndrome , colon adenocarcinoma , colon carcinoma , colorectal cancer , colorectal carcinoma , Colorectal Neoplasms , complex cortical dysplasia with other brain malformations , Cowden syndrome , Cowden syndrome 5 , Currarino syndrome , cutaneous Paget's disease , Developmental Disabilities , Diabetic Cardiomyopathies , diaphragmatic eventration , diffuse large B-cell lymphoma , Disease Progression , Down syndrome , endometrial carcinoma , Endometrial Neoplasms , epidermal nevus , esophageal cancer , esophageal carcinoma , esophagus adenocarcinoma , estrogen-receptor positive breast cancer , Facial Asymmetry , familial multiple nevi flammei , gallbladder cancer , gastric adenocarcinoma , Gastrointestinal Neoplasms , genetic disease , glioblastoma , glycogen storage disease II , Growth Disorders , head and neck squamous cell carcinoma , Hemifacial Myohyperplasia , Hemimegalencephaly , hepatocellular carcinoma , Hereditary Neoplastic Syndromes , high grade glioma , Hyperplasia , Hypertelorism , keratoacanthoma , Klippel-Trenaunay syndrome , liver cancer , lung adenocarcinoma , lung cancer , lung carcinoma , Lung Neoplasms , lung non-small cell carcinoma , lung small cell carcinoma , lung squamous cell carcinoma , lymphangioma , Lymphatic Metastasis , Macrocephaly , medulloblastoma , Megalencephaly - Cutis Marmorata Telangiectatica Congenita , Megalencephaly-Polymicrogyria-Polydactyly-Hydrocephalus Syndrome , Megalodactyly , melanoma , Mouth Neoplasms , Myoectodermal Gonadal Dysgenesis Syndrome , Neoplasm Metastasis , NEURODEVELOPMENTAL DISORDER WITH MICROCEPHALY, ARTHROGRYPOSIS, AND STRUCTURAL BRAIN ANOMALIES , ovarian cancer , Ovarian Neoplasms , Penile Neoplasms , polycystic kidney disease , prostate adenocarcinoma , prostate cancer , Prostatic Neoplasms , PTEN hamartoma tumor syndrome , rectal benign neoplasm , renal cell carcinoma , rosette-forming glioneuronal tumor , sarcoma , seborrheic keratosis , skin melanoma , squamous cell carcinoma , stomach cancer , Stomach Neoplasms , Stroke , urinary bladder cancer , Vascular Malformations , Ventricular Dysfunction, Left , Weight Gain Pik3cb colorectal cancer , diffuse large B-cell lymphoma , endometrial cancer , Endometrial Neoplasms , glioblastoma , hepatocellular carcinoma , Lymphatic Metastasis , NATURAL KILLER CELL ENTEROPATHY , prostate adenocarcinoma , prostate cancer , Prostatic Neoplasms , rectal benign neoplasm , schizophrenia , Subarachnoid Hemorrhage , thrombosis , type 2 diabetes mellitus Pik3cd Charcot-Marie-Tooth disease type 2 , Chlamydia pneumonia , chromosome 1p36 deletion syndrome , colorectal cancer , cutaneous leishmaniasis , diffuse large B-cell lymphoma , endometrial cancer , Experimental Arthritis , genetic disease , glioblastoma , immunodeficiency 14 , listeriosis , mantle cell lymphoma , Neurodevelopmental Disorders , primary immunodeficiency disease , Prostatic Neoplasms , Roifman-Chitayat Syndrome , schizophrenia , Streptococcus pneumonia , toxic shock syndrome , visceral leishmaniasis Pik3r1 agammaglobulinemia 7 , Alzheimer's disease , Animal Mammary Neoplasms , astroblastoma , Breast Neoplasms , Burkitt lymphoma , carcinoma , CLOVES syndrome , Colonic Neoplasms , colorectal cancer , endometrial adenocarcinoma , endometrial cancer , endometrial carcinoma , Experimental Diabetes Mellitus , Experimental Mammary Neoplasms , genetic disease , glucose intolerance , hepatocellular carcinoma , hypertension , hypoglycemia , immunodeficiency 14 , immunodeficiency 36 , Insulin Resistance , lung adenocarcinoma , lung small cell carcinoma , Megalencephaly - Cutis Marmorata Telangiectatica Congenita , Nematode Infections , Neurodevelopmental Disorders , obesity , osteoarthritis , Ovarian Neoplasms , portal hypertension , primary immunodeficiency disease , prostate cancer , Prostatic Neoplasms , renal cell carcinoma , Reperfusion Injury , rheumatoid arthritis , Septic Peritonitis , SHORT syndrome , Smith-Kingsmore Syndrome , type 2 diabetes mellitus , Vascular Malformations , vitiligo , X-linked agammaglobulinemia Pik3r2 colon cancer , Colonic Neoplasms , Developmental Disabilities , epilepsy , genetic disease , hepatocellular carcinoma , intellectual disability , Megalencephaly - Cutis Marmorata Telangiectatica Congenita , Megalencephaly-Polymicrogyria-Polydactyly-Hydrocephalus Syndrome , Megalencephaly-Polymicrogyria-Polydactyly-Hydrocephalus Syndrome 1 , multiple myeloma , pancreatic ductal adenocarcinoma , prostate cancer , Prostatic Neoplasms , Smith-Kingsmore Syndrome Pik3r3 Breast Cancer, Familial , Charcot-Marie-Tooth disease dominant intermediate C , colon adenocarcinoma , Colorectal Neoplasms , developmental and epileptic encephalopathy , early infantile epileptic encephalopathy , hepatocellular carcinoma , high grade glioma , Neoplasm Metastasis Pik3r5 ataxia with oculomotor apraxia type 3 , colon cancer , spastic ataxia Pms1 breast cancer , Colonic Polyps , colorectal cancer , Colorectal Neoplasms , dermatomyositis , hereditary breast ovarian cancer syndrome , immunodeficiency 31B , Lynch syndrome , Lynch syndrome 1 , Neurodevelopmental Disorders , ovarian cancer , pancreatic ductal carcinoma , polymyositis , Prostatic Neoplasms Pms2 autosomal recessive progressive external ophthalmoplegia 1 , Brain Neoplasms , breast cancer , Breast Cancer, Familial , breast carcinoma , Breast Neoplasms , Cafe-au-Lait Spots , colon cancer , colon carcinoma , Colonic Neoplasms , Colonic Polyps , Colorectal Neoplasms , diffuse large B-cell lymphoma , diffuse pediatric-type high-grade glioma, H3-wildtype and IDH-wildtype , dilated cardiomyopathy 1G , endometrial carcinoma , hepatocellular carcinoma , hereditary breast ovarian cancer syndrome , Hereditary Neoplastic Syndromes , hereditary nonpolyposis colorectal cancer type 4 , hereditary nonpolyposis colorectal cancer type 5 , hypertrophic cardiomyopathy 9 , Lynch syndrome , Lynch syndrome 1 , mismatch repair cancer syndrome , Mismatch Repair Cancer Syndrome 1 , Mismatch Repair Cancer Syndrome 4 , Neoplasm Metastasis , ovarian cancer , Ovarian Neoplasms , pituitary carcinoma , Primitive Neuroectodermal Tumors , prostate cancer , Pulmonary Arterial Hypertension , rhabdomyosarcoma , stomach cancer , Supratentorial Neoplasms , urinary bladder cancer Rac1 autosomal dominant intellectual developmental disorder 48 , breast cancer , Cardiomegaly , Cardiotoxicity , colon adenocarcinoma , colon adenoma , colorectal adenocarcinoma , colorectal cancer , colorectal carcinoma , congestive heart failure , Developmental Disabilities , Developmental Disease , diabetes mellitus , dilated cardiomyopathy , extrahepatic bile duct adenocarcinoma , gallbladder carcinoma , gastric adenocarcinoma , genetic disease , hepatocellular carcinoma , Left Ventricular Hypertrophy , liver disease , lung adenocarcinoma , lung cancer , melanoma , nasopharynx carcinoma , Neoplasm Metastasis , Neoplastic Cell Transformation , neurodevelopmental disorder with dysmorphic facies and distal limb anomalies , pancreatic adenocarcinoma , pancreatic ductal adenocarcinoma , Sepsis , stomach cancer , Ventricular Dysfunction, Left Rac2 acute myeloid leukemia , adenylosuccinase lyase deficiency , Chronic Periodontitis , Disease Progression , Emery-Dreifuss muscular dystrophy , Experimental Liver Cirrhosis , genetic disease , heart disease , immunodeficiency 73a with defective neutrophil chemotaxis and leukocytosis , immunodeficiency 73b with defective neutrophil chemotaxis and lymphopenia , immunodeficiency 73c with defective neutrophil chemotaxis and hypogammaglobulinemia , juvenile myelomonocytic leukemia , lymphoma , melanoma , myoclonic dystonia 26 , neurodegeneration with brain iron accumulation 2A , prostate cancer , severe combined immunodeficiency Raf1 Breast Neoplasms , Cardiomegaly , colorectal adenocarcinoma , colorectal adenoma , dilated cardiomyopathy , dilated cardiomyopathy 1B , dilated cardiomyopathy 1NN , Dilated Cardiomyopathy with Left Ventricular Noncompaction , familial hypertrophic cardiomyopathy , genetic disease , hereditary breast ovarian cancer syndrome , high grade glioma , Hyperalgesia , hypertrophic cardiomyopathy , hypertrophic cardiomyopathy 1 , ischemia , Kidney Neoplasms , Liver Neoplasms , lung adenocarcinoma , Lung Neoplasms , lung non-small cell carcinoma , Lymphangiectasis , malignant mesothelioma , Noonan syndrome , Noonan syndrome 1 , Noonan syndrome 3 , Noonan syndrome 5 , Noonan syndrome with multiple lentigines , Noonan syndrome with multiple lentigines 2 , ovarian carcinoma , pancreatic adenocarcinoma , pancreatic carcinoma , Pituitary Stalk Interruption Syndrome , prostate adenocarcinoma , prostate cancer , Prostatic Neoplasms , RASopathy , Ventricular Tachycardia Ralgds developmental and epileptic encephalopathy 14 , Ehlers-Danlos syndrome classic type 1 , hereditary breast ovarian cancer syndrome , intellectual disability , Leigh disease , primary coenzyme Q10 deficiency 7 , Rafiq syndrome , tuberous sclerosis 1 Rhoa Abnormalities, Drug-Induced , acute myocardial infarction , Aicardi-Goutieres Syndrome 1 , alopecia , Animal Disease Models , asthma , autosomal recessive limb-girdle muscular dystrophy type 2P , Brain Injuries , breast cancer , breast carcinoma , carcinoma , Cardiomegaly , carnitine-acylcarnitine translocase deficiency , Cocaine-Related Disorders , colorectal cancer , congenital diaphragmatic hernia , Craniofacial Abnormalities , Diabetic Nephropathies , ectodermal dysplasia , ECTODERMAL DYSPLASIA WITH FACIAL DYSMORPHISM AND ACRAL, OCULAR, AND BRAIN ANOMALIES , Experimental Autoimmune Encephalomyelitis , Experimental Autoimmune Neuritis , Experimental Diabetes Mellitus , Experimental Liver Cirrhosis , fetal alcohol syndrome , Fibrosis , genetic disease , Germ Cell and Embryonal Neoplasms , glycine encephalopathy , hypertension , Hypopigmentation , Immunoblastic Lymphadenopathy , Left Ventricular Hypertrophy , Leukoencephalopathies , Lymphatic Metastasis , membranous glomerulonephritis , multiple sclerosis , Myocardial Reperfusion Injury , Neoplasm Invasiveness , Neoplasm Metastasis , Neurocutaneous Syndromes , obesity , Optic Nerve Injuries , ovarian carcinoma , peripheral T-cell lymphoma , Pierson syndrome , primary biliary cholangitis , primary cutaneous T-cell non-Hodgkin lymphoma , proteinuria , pulmonary hypertension , Spinal Cord Injuries , Stomach Neoplasms , T-cell non-Hodgkin lymphoma , tooth disease , urinary bladder cancer , Urologic Neoplasms , withdrawal disorder Smad2 acromicric dysplasia , breast carcinoma , cervical cancer , chromosome 18q deletion syndrome , Chronic Hepatitis , colon cancer , CONGENITAL HEART DEFECTS, MULTIPLE TYPES, 8, WITH OR WITHOUT HETEROTAXY , Copper-Overload Cirrhosis , Craniofacial Abnormalities , endometrial cancer , Experimental Liver Cirrhosis , female reproductive system disease , genetic disease , hepatocellular carcinoma , Hypoglossal Nerve Injuries , idiopathic pulmonary fibrosis , intellectual disability , Loeys-Dietz syndrome , Loeys-Dietz syndrome 6 , Lynch syndrome , Microcephaly, Epilepsy, and Diabetes Syndrome , myocardial infarction , ovarian cancer , ovarian carcinoma , pancreatic cancer , pancreatic ductal adenocarcinoma , renal cell carcinoma , scimitar syndrome , thoracic aortic aneurysm , urinary bladder cancer , Ventricular Remodeling , Vici syndrome Smad3 alcoholic liver cirrhosis , Aneurysm , aortic aneurysm , aortic disease , aortic dissection , aortic valve disease 2 , ARTERIAL DISSECTION , Bloom syndrome , cervical squamous cell carcinoma , Cocaine-Related Disorders , colorectal cancer , Colorectal Neoplasms , connective tissue disease , coronary artery disease , Craniofacial Abnormalities , Crohn's disease , Dissecting Aneurysm , Ehlers-Danlos syndrome , endometrial cancer , Experimental Liver Cirrhosis , Familial Thoracic Aortic Aneurysm 1 , Familial Thoracic Aortic Aneurysm 6 , Hypoglossal Nerve Injuries , juvenile rheumatoid arthritis , leiomyoma , liver cirrhosis , Loeys-Dietz syndrome , Loeys-Dietz syndrome 3 , lung cancer , lung non-small cell carcinoma , Lynch syndrome , myocardial infarction , Myocardial Reperfusion Injury , neuronal ceroid lipofuscinosis , osteoarthritis , Osteoarthritis, Hip , pancreatic cancer , pre-malignant neoplasm , prostate cancer , thoracic aortic aneurysm , Tubulointerstitial Fibrosis , ureteral obstruction , Uterine Neoplasms , Ventricular Remodeling Smad4 17-beta hydroxysteroid dehydrogenase 3 deficiency , Acro-Osteolysis , aortic disease , brachydactyly , breast cancer , Breast Neoplasms , cervical cancer , cholangiocarcinoma , Chronic Hepatitis C , chronic myeloid leukemia , chronic obstructive pulmonary disease , Cicatrix , cognitive disorder , colon cancer , colon carcinoma , colorectal adenoma , colorectal cancer , colorectal carcinoma , Colorectal Neoplasms , Craniofacial Abnormalities , Cronkhite-Canada syndrome , Deafness , endometrial carcinoma , esophageal carcinoma , esophagus adenocarcinoma , Experimental Colitis , Experimental Liver Cirrhosis , Familial Pancreatic Carcinoma , gallbladder cancer , Gallstones , gastrointestinal system cancer , Growth Mental Deficiency Syndrome of Myhre , head and neck squamous cell carcinoma , hemorrhagic disease , hepatocellular carcinoma , hereditary breast ovarian cancer syndrome , hereditary hemorrhagic telangiectasia , Hereditary Hemorrhagic Telangiectasia, Type 1 , Hereditary Neoplastic Syndromes , Heterotopic Ossification , Human Viral Hepatitis , Hypoglossal Nerve Injuries , intellectual disability , intrahepatic cholangiocarcinoma , invasive ductal carcinoma , juvenile polyposis syndrome , juvenile polyposis-hereditary hemorrhagic telangiectasia syndrome , Liver Metastasis , lung adenocarcinoma , lung cancer , Lymphatic Metastasis , Lynch syndrome , metabolic dysfunction-associated steatohepatitis , Microphthalmia, Cataracts, and Iris Abnormalities , muscular disease , myocardial infarction , Myocardial Reperfusion Injury , Neoplasm Metastasis , nephroblastoma , Odontogenic Cysts , osteogenesis imperfecta , ovarian cancer , pancreatic cancer , pancreatic carcinoma , pancreatic ductal carcinoma , Parasitic Liver Diseases , pre-malignant neoplasm , primary pulmonary hypertension 1 , prostate carcinoma in situ , Prostatic Neoplasms , prostatitis , Pulmonary Arterial Hypertension , pulmonary fibrosis , pulmonary hypertension , renal cell carcinoma , seminoma , stomach cancer , Stomach Neoplasms , thoracic aortic aneurysm , transitional cell carcinoma , type 2 diabetes mellitus , urinary bladder cancer , Uterine Cervical Neoplasms , vascular dementia Smad7 atrial fibrillation , chromosome 18q deletion syndrome , colorectal cancer , Colorectal Neoplasms , endometrial cancer , hepatocellular carcinoma , hereditary breast ovarian cancer syndrome , Hypoglossal Nerve Injuries , intellectual disability , liver cirrhosis , nephritis , Ovarian Neoplasms , pancreatic adenocarcinoma , pancreatic cancer , Paraquat Lung , pulmonary fibrosis , pulmonary hypertension Tcf3 acute lymphoblastic leukemia , agammaglobulinemia , Agammaglobulinemia 8 , agammaglobulinemia 8A , agammaglobulinemia 8B , B-lymphoblastic leukemia/lymphoma , Burkitt lymphoma , cerebral creatine deficiency syndrome , colorectal cancer , cyclic hematopoiesis , genetic disease , multicentric Castleman disease , multiple myeloma , myeloproliferative neoplasm , Neoplasm Metastasis , Neurodevelopmental Disorders , progressive myoclonus epilepsy 9 , prostate cancer Tcf7 Crohn's disease , familial adenomatous polyposis 1 , Hereditary Neoplastic Syndromes , Mycoplasma pneumoniae pneumonia , Neurodevelopmental Disorders , prostate cancer , systemic lupus erythematosus Tcf7l2 adenocarcinoma , Animal Disease Models , autistic disorder , breast cancer , Colonic Neoplasms , colorectal cancer , Colorectal Neoplasms , Coronary Disease , diabetes mellitus , Diabetic Nephropathies , dilated cardiomyopathy , Familial Prostate Cancer , genetic disease , gestational diabetes , Hyperalgesia , Hyperplasia , Insulin Resistance , intellectual disability , juvenile rheumatoid arthritis , maturity-onset diabetes of the young type 1 , Myocardial Ischemia , Neurodevelopmental Disorders , pancreatic cancer , prostate cancer , type 2 diabetes mellitus , Ventricular Remodeling Tgfb1 acromicric dysplasia , actinic keratosis , acute kidney failure , Acute Lung Injury , adenocarcinoma , alcoholic liver cirrhosis , allergic conjunctivitis , allergic disease , allergic rhinitis , Anetoderma , anogenital venereal wart , aortic valve insufficiency , aphthous stomatitis , aplastic anemia , arteriosclerosis , asthma , atopic dermatitis , atrial fibrillation , autoimmune hepatitis , autoimmune thrombocytopenic purpura , bacterial pneumonia , Behcet's disease , berylliosis , biliary atresia , brain disease , brain ischemia , breast cancer , Cachexia , calcinosis , Camurati-Engelmann disease , carcinoma , carcinosarcoma , Cardiac Fibrosis , Cardiomegaly , carotid artery disease , Carotid Artery Injuries , Carpenter Syndrome 2 , Chemical and Drug Induced Liver Injury , chlamydia , cholangiocarcinoma , chorioamnionitis , Chronic Experimental Pancreatitis , Chronic Hepatitis , Chronic Hepatitis B , chronic myeloid leukemia , chronic obstructive pulmonary disease , cleft palate , colon adenocarcinoma , colon cancer , colon carcinoma , colorectal cancer , Colorectal Neoplasms , congenital hypoplastic anemia , Copper-Overload Cirrhosis , coronary artery disease , craniosynostosis 1 , cystic fibrosis , degenerative disc disease , diabetes mellitus , Diabetic Nephropathies , diabetic neuropathy , Diamond-Blackfan anemia , Diaphragmatic Hernia , Dilatation, Pathologic , dry eye syndrome , Duchenne muscular dystrophy , duodenal ulcer , Ehlers-Danlos syndrome , end stage renal disease , endomyocardial fibrosis , eosinophilic esophagitis , epilepsy , essential thrombocythemia , Experimental Arthritis , Experimental Autoimmune Encephalomyelitis , Experimental Diabetes Mellitus , Experimental Liver Cirrhosis , Experimental Liver Neoplasms , Experimental Mammary Neoplasms , extrahepatic cholestasis , factor VIII deficiency , familial hyperlipidemia , Fibrosis , focal segmental glomerulosclerosis , Gallbladder Neoplasms , genetic disease , gout , Graves' disease , heart disease , Heart Injuries , Hemorrhagic Shock , hepatic encephalopathy , Hepatic Insufficiency , hepatocellular carcinoma , Hepatomegaly , Hereditary Hemorrhagic Telangiectasia, Type 1 , Hyperoxia , Hyperplasia , hypertension , hypertrophic cardiomyopathy , hyperuricemia , IgA glomerulonephritis , impotence , Infant, Newborn, Diseases , Inflammation , inflammatory bowel disease , INFLAMMATORY BOWEL DISEASE, IMMUNODEFICIENCY, AND ENCEPHALOPATHY , insulinoma , interstitial lung disease , Joubert syndrome 1 , kidney disease , Kidney Reperfusion Injury , liver cirrhosis , localized scleroderma , lung disease , Lung Neoplasms , Lymphomatoid Papulosis , maple syrup urine disease , Meckel Syndrome 10 , metabolic dysfunction and alcohol associated liver disease , metabolic dysfunction-associated steatotic liver disease , Metabolic Syndrome , middle cerebral artery infarction , multiple myeloma , muscular disease , myelofibrosis , myocardial infarction , Myocardial Reperfusion Injury , Nasal Polyps , Neoplasm Invasiveness , Neoplasm Metastasis , Neoplastic Cell Transformation , nephrolithiasis , nephrosclerosis , nephrotic syndrome , nephrotoxicity , Neuralgia , obesity , occupational asthma , Occupational Diseases , oral submucous fibrosis , osteoarthritis , osteochondrodysplasia , osteoporosis , pancreatic cancer , pancreatic ductal adenocarcinoma , pancreatic ductal carcinoma , papilloma , Paraquat Lung , Peritoneal Fibrosis , Peyronie's disease , pleural disease , pneumonia , Posterior Leukoencephalopathy Syndrome , Postmenopausal Osteoporosis , primary biliary cholangitis , Progressive Diaphyseal Dysplasia 1 , prostate cancer , Prostatic Neoplasms , proteinuria , psoriasis , pulmonary emphysema , pulmonary fibrosis , pulmonary hypertension , pulmonary sarcoidosis , Radiation Pneumonitis , renal cell carcinoma , rhinitis , Right Ventricular Hypertrophy , sarcoidosis , Sepsis , severe acute respiratory syndrome , sickle cell anemia , Sjogren's syndrome , Skin Neoplasms , Spinal Cord Injuries , Spontaneous Abortions , Spontaneous Neoplasm Regression , squamous cell carcinoma , Stroke , thrombocytopenia , tracheal stenosis , traumatic brain injury , Tubulointerstitial Fibrosis , type 1 diabetes mellitus , type 2 diabetes mellitus , uremia , ureteral obstruction , urethral obstruction , urticaria , uveitis , Ventricular Remodeling , vitiligo , Wallerian Degeneration , Wounds and Injuries Tgfb2 Aberrant Crypt Foci , aortic aneurysm , aortic disease , aortic valve insufficiency , atrial heart septal defect 1 , autoimmune disease , basal cell carcinoma , bone development disease , cholangitis , cleft palate , colon carcinoma , colorectal cancer , Colorectal Neoplasms , congenital heart disease , Congenital Limb Deformities , connective tissue disease , Craniofacial Abnormalities , Cyanosis , diabetic neuropathy , Ehlers-Danlos syndrome , endometriosis , Experimental Autoimmune Encephalomyelitis , Experimental Diabetes Mellitus , Eye Abnormalities , gastrointestinal stromal tumor , genetic disease , glaucoma , hepatocellular carcinoma , Hirschsprung Disease 1 , Hirschsprung's disease , Holt-Oram syndrome , liver cirrhosis , Loeys-Dietz syndrome , Loeys-Dietz syndrome 4 , lung adenocarcinoma , malignant mesothelioma , Martsolf Syndrome , Musculoskeletal Abnormalities , myocardial infarction , osteochondrodysplasia , pancreatic adenosquamous carcinoma , pancreatic ductal adenocarcinoma , parathyroid carcinoma , Respiratory System Abnormalities , Spinal Cord Injuries , thoracic aortic aneurysm , ureteral obstruction , Urogenital Abnormalities , Usher syndrome , Wallerian Degeneration , Wounds and Injuries Tgfb3 arrhythmogenic right ventricular cardiomyopathy , arrhythmogenic right ventricular dysplasia 1 , Brugada syndrome , cardiomyopathy , Carotid Artery Injuries , cleft palate , colon cancer , colorectal cancer , Contracture , cranioectodermal dysplasia , Developmental Disease , diabetic neuropathy , dilated cardiomyopathy , Experimental Liver Cirrhosis , hypertension , hypertrophic cardiomyopathy , intellectual disability , left ventricular noncompaction , Loeys-Dietz syndrome , Loeys-Dietz syndrome 4 , Loeys-Dietz syndrome 5 , long QT syndrome , nonsyndromic deafness , pancreatic ductal adenocarcinoma , Respiratory System Abnormalities , thoracic aortic aneurysm , Ventricular Premature Complexes , Wounds and Injuries Tgfbr1 acute kidney failure , Animal Disease Models , aortic aneurysm , aortic disease , Carotid Artery Injuries , Charlevoix-Saguenay spastic ataxia , Chemical and Drug Induced Liver Injury , colorectal cancer , Colorectal Neoplasms , congenital disorder of glycosylation Ii , congenital disorder of glycosylation type II , congenital myasthenic syndrome 14 , connective tissue disease , craniosynostosis , Craniosynostosis Syndrome, Autosomal Recessive , diffuse scleroderma , Disproportionate Tall Stature , Dissecting Aneurysm , Ehlers-Danlos syndrome , Ehlers-Danlos syndrome classic type 1 , Experimental Liver Cirrhosis , Experimental Mammary Neoplasms , Familial Thoracic Aortic Aneurysm 6 , Ferguson-Smith tumor , Hyperalgesia , intellectual disability , kidney disease , leiomyoma , liver cirrhosis , Loeys-Dietz syndrome , Loeys-Dietz syndrome 1 , Lynch syndrome , Marfan syndrome , Marfanoid Hypermobility Syndrome , methylmalonic aciduria due to methylmalonyl-CoA mutase deficiency , myocardial infarction , myoepithelioma , Neoplasm Metastasis , nephronophthisis , osteoarthritis , osteochondrodysplasia , pancreatic ductal adenocarcinoma , Pulmonary Arterial Hypertension , pulmonary hypertension , Skin Neoplasms , Spontaneous Abortions , systemic scleroderma , thoracic aortic aneurysm , uremia , urinary bladder cancer Tgfbr2 aortic aneurysm , arteriosclerosis , bone disease , Bone Fractures , Bone Neoplasms , Brain Neoplasms , carcinoma , Carotid Artery Injuries , cholangiocarcinoma , cleft soft palate , colon cancer , Colonic Neoplasms , colorectal cancer , connective tissue disease , Craniofacial Abnormalities , Diabetic Nephropathies , diabetic retinopathy , DiGeorge syndrome , Dissecting Aneurysm , Ehlers-Danlos syndrome , esophageal cancer , Esophageal Neoplasms , esophagus squamous cell carcinoma , Experimental Arthritis , Experimental Liver Cirrhosis , Experimental Mammary Neoplasms , Eye Abnormalities , Familial Thoracic Aortic Aneurysm 1 , Fatigue , gastrointestinal stromal tumor , genetic disease , hepatoblastoma , hepatocellular carcinoma , hereditary nonpolyposis colorectal cancer type 6 , Hyperplasia , hypomyelinating leukodystrophy 7 , inguinal hernia , kidney disease , Loeys-Dietz syndrome , Loeys-Dietz syndrome 1 , Loeys-Dietz syndrome 2 , Loeys-Dietz Syndrome, Type 1b , Lung Neoplasms , Lynch syndrome , Marfan syndrome , Marfan Syndrome Type 2 , Marfanoid Hypermobility Syndrome , membranoproliferative glomerulonephritis , Microsatellite Instability , migraine , mismatch repair cancer syndrome , multiple acyl-CoA dehydrogenase deficiency , myocardial infarction , Neoplasm Metastasis , pancreatic cancer , pancreatic ductal carcinoma , prostate cancer , Prostatic Neoplasms , pulmonary fibrosis , pulmonary hypertension , Radiation Injuries , Reperfusion Injury , thoracic aortic aneurysm , type 2 diabetes mellitus , vasculogenic impotence , Wolff-Parkinson-White syndrome Tp53 Acute Erythroleukemia , acute kidney failure , acute lymphoblastic leukemia , acute megakaryocytic leukemia , acute myeloid leukemia , adenocarcinoma , adenoid cystic carcinoma , adenoma , Adrenal Cortex Neoplasms , Adrenal Gland Neoplasms , adrenocortical carcinoma , adult T-cell leukemia/lymphoma , Alzheimer's disease , amyotrophic lateral sclerosis , anaplastic astrocytoma , anaplastic thyroid carcinoma , angiosarcoma , Animal Disease Models , Arsenic Poisoning , atherosclerosis , atypical teratoid rhabdoid tumor , Autosomal Recessive Dyskeratosis Congenita , autosomal recessive dyskeratosis congenita 3 , B-Cell Chronic Lymphocytic Leukemia , B-lymphoblastic leukemia/lymphoma , Balkan nephropathy , basal cell carcinoma , bone development disease , Bone Marrow Failure Syndrome 5 , Bone Marrow Neoplasms , bone osteosarcoma , brain ischemia , Brain Neoplasms , breast adenocarcinoma , breast cancer , Breast Cancer, Familial , breast carcinoma , Breast Neoplasms , bronchiolo-alveolar adenocarcinoma , bronchopulmonary dysplasia , Calcification of Aortic Valve , calcinosis , carcinoma , cardiomyopathy , Cardiotoxicity , carotid artery disease , cataract , Cecal Neoplasms , Central Nervous System Neoplasms , cervical adenocarcinoma , cervical cancer , cervical squamous cell carcinoma , CHARGE syndrome , Chemotherapy-Induced Febrile Neutropenia , cholangiocarcinoma , cholesteatoma of middle ear , choroid plexus carcinoma , choroid plexus papilloma , Chromosome 17 Deletion , chronic lymphocytic leukemia , chronic obstructive pulmonary disease , clear cell adenocarcinoma , clear cell renal cell carcinoma , Cognitive Dysfunction , colon carcinoma , Colon Diverticulum , Colonic Neoplasms , colorectal adenocarcinoma , colorectal cancer , colorectal carcinoma , Colorectal Neoplasms , common variable immunodeficiency , congenital fibrosarcoma , congenital merosin-deficient muscular dystrophy 1A , congenital myasthenic syndrome 2A , congestive heart failure , coronary artery disease , coronary restenosis , Craniofacial Abnormalities , demyelinating disease , Diabetic Nephropathies , Diamond-Blackfan anemia , diffuse large B-cell lymphoma , diffuse pediatric-type high-grade glioma, H3-wildtype and IDH-wildtype , DiGeorge syndrome , dilated cardiomyopathy , disease of cellular proliferation , Disease Progression , Drug-induced Neutropenia , Drug-Related Side Effects and Adverse Reactions , Ductal Carcinoma , ductal carcinoma in situ , Dwarfism , dyskeratosis congenita , Emphysema , endometrial adenocarcinoma , endometrial cancer , endometrial carcinoma , Endometrial Intraepithelial Neoplasia , Endometrial Neoplasms , esophageal cancer , esophageal carcinoma , Esophageal Neoplasms , esophagus adenocarcinoma , esophagus squamous cell carcinoma , Experimental Diabetes Mellitus , Experimental Liver Neoplasms , Experimental Mammary Neoplasms , Experimental Neoplasms , Eye Neoplasms , familial melanoma , Familial Pancreatic Carcinoma , Female Infertility , Funnel Chest , gallbladder cancer , Gallbladder Neoplasms , gastric adenocarcinoma , glioblastoma , graft-versus-host disease , Graves' disease , head and neck squamous cell carcinoma , hematologic cancer , hepatoblastoma , hepatocellular carcinoma , Hereditary Adrenocortical Carcinoma , hereditary breast ovarian cancer syndrome , Hereditary Neoplastic Syndromes , high grade glioma , hypertension , hypertrophic cardiomyopathy , Hypogonadism and Testicular Atrophy , ischemia , Kaposi's sarcoma , keratosis , Leber hereditary optic neuropathy , leukemia , Li-Fraumeni syndrome , Li-Fraumeni syndrome 1 , Li-Fraumeni-Like Syndrome , Lip Neoplasms , Liver Neoplasms , low tension glaucoma , lung adenocarcinoma , Lung Neoplasms , lung non-small cell carcinoma , lung sarcomatoid carcinoma , lung small cell carcinoma , lung squamous cell carcinoma , Lymphatic Metastasis , lymphoma , male infertility , malignant astrocytoma , malignant mesothelioma , marginal zone lymphoma , medulloblastoma , melanoma , meninges sarcoma , Mesothelioma , mismatch repair cancer syndrome , mitochondrial metabolism disease , Mouth Neoplasms , multiple myeloma , myelodysplastic syndrome , myelofibrosis , myeloid leukemia associated with Down Syndrome , myeloid neoplasm , myocardial infarction , Myocardial Reperfusion Injury , nasal cavity cancer , Nasopharyngeal Neoplasms , nasopharynx carcinoma , Neoplasm Metastasis , Neoplastic Cell Transformation , nephroblastoma , Nerve Sheath Neoplasms , nervous system disease , neuroblastoma , non-Hodgkin lymphoma , Odontogenic Myxoma , Oral Lichen Planus , oral mucosa leukoplakia , oral squamous cell carcinoma , oral submucous fibrosis , Oropharyngeal Neoplasms , osteosarcoma , ovarian cancer , ovarian carcinoma , Ovarian Neoplasms , ovarian small cell carcinoma , ovary serous adenocarcinoma , pancreatic cancer , pancreatic carcinoma , pancreatic ductal carcinoma , pancreatic intraductal papillary-mucinous neoplasm , pancytopenia , papillary thyroid carcinoma , paranasal sinus benign neoplasm , Paraproteinemias , Parasitic Liver Diseases , Pediatric Adrenocortical Carcinoma , Penile Neoplasms , Phyllodes Tumor , plasma cell neoplasm , pleomorphic xanthoastrocytoma , Pleural Effusion , Polyploidy , pre-malignant neoplasm , Premature Aging , primary cutaneous T-cell non-Hodgkin lymphoma , primary open angle glaucoma , prostate adenocarcinoma , prostate cancer , Prostate Cancer, Hereditary, 1 , Prostatic Neoplasms , psoriasis , pterygium , pulmonary hypertension , renal cell carcinoma , Reperfusion Injury , rhabdomyosarcoma , SAPHO syndrome , sarcoma , schizophrenia , serous cystadenocarcinoma , Sezary's disease , skin melanoma , Skin Neoplasms , small cell carcinoma , Spinal Cord Injuries , spondyloarthropathy , squamous cell carcinoma , stomach cancer , Stomach Neoplasms , T-cell non-Hodgkin lymphoma , thymoma , Thymus Neoplasms , Thyroid Neoplasms , Tongue Neoplasms , tongue squamous cell carcinoma , transitional cell carcinoma , transthyretin amyloidosis , traumatic brain injury , Trigeminal Nerve Injuries , ulcerative colitis , urinary bladder cancer , Urinary Bladder Neoplasm , Urogenital Neoplasms , Urologic Neoplasms , vascular dementia , very long chain acyl-CoA dehydrogenase deficiency , Vulvar Lichen Sclerosus , Vulvar Neoplasms , xeroderma pigmentosum
17-beta hydroxysteroid dehydrogenase 3 deficiency Smad4 abdominal aortic aneurysm Casp3 , Mapk8 Abdominal Fibromatosis Apc abdominal obesity-metabolic syndrome 1 Bax , Bcl2 Aberrant Crypt Foci Apc , Ctnnb1 , Fos , Gsk3b , Mapk1 , Mapk3 , Myc , Tgfb2 Abnormalities, Drug-Induced Rhoa acinar cell carcinoma Apc Acro-Osteolysis Smad4 acromicric dysplasia Smad2 , Tgfb1 actinic keratosis Tgfb1 Acute Erythroleukemia Tp53 Acute Experimental Pancreatitis Kras acute kidney failure Bad , Bax , Bcl2 , Gsk3b , Myc , Tgfb1 , Tgfbr1 , Tp53 Acute Liver Failure Casp3 , Casp9 , Mapk8 Acute Lung Injury Akt1 , Bax , Bcl2 , Casp3 , Tgfb1 acute lymphoblastic leukemia Bax , Bcl2 , Ccnd1 , Kras , Myc , Tcf3 , Tp53 acute megakaryocytic leukemia Birc5 , Tp53 acute myeloid leukemia Bcl2 , Ccnd1 , Kras , Myc , Rac2 , Tp53 acute myocardial infarction Bax , Casp3 , Fos , Gsk3b , Rhoa acute necrotizing pancreatitis Birc5 , Casp3 Acute Otitis Media Mapk8 acute pancreatitis Birc5 acute promyelocytic leukemia Akt1 , Birc5 , Myc adenocarcinoma Akt1 , Akt2 , Apc , Bcl2 , Birc5 , Ccnd1 , Ctnnb1 , Kras , Myc , Pik3ca , Tcf7l2 , Tgfb1 , Tp53 adenoid cystic carcinoma Ccnd1 , Pik3ca , Tp53 adenoma Apc , Bcl2 , Ctnnb1 , Kras , Tp53 Adenomatous Polyps Apc adenylosuccinase lyase deficiency Rac2 Adrenal Cortex Neoplasms Ctnnb1 , Tp53 Adrenal Gland Neoplasms Ctnnb1 , Tp53 Adrenal Insufficiency Bax , Bcl2 adrenocortical carcinoma Birc5 , Braf , Ctnnb1 , Tp53 adult respiratory distress syndrome Apc adult T-cell leukemia/lymphoma Birc5 , Tp53 agammaglobulinemia Tcf3 agammaglobulinemia 7 Pik3r1 Agammaglobulinemia 8 Tcf3 agammaglobulinemia 8A Tcf3 agammaglobulinemia 8B Tcf3 Agenesis of Corpus Callosum Dcc , Pik3ca Aggressive Fibromatosis Apc Aicardi-Goutieres Syndrome 1 Rhoa Aicardi-Goutieres Syndrome 3 Ccnd1 AIDS-Related Kaposi Sarcoma Bcl2 Alazami Syndrome Ctnnb1 alcohol dependence Fos , Mapk1 , Mapk3 alcohol use disorder Apc2 , Fos , Mapk1 , Mapk3 , Mapk8 alcohol withdrawal syndrome Fos Alcohol-Related Disorders Fos , Jun alcoholic hepatitis Akt1 Alcoholic Intoxication Fos alcoholic liver cirrhosis Bcl2 , Smad3 , Tgfb1 Alcoholic Liver Diseases Akt1 , Myc allergic conjunctivitis Tgfb1 allergic contact dermatitis Bcl2 allergic disease Tgfb1 allergic rhinitis Bcl2 , Tgfb1 alopecia Rhoa Alzheimer's disease Akt1 , Apc , Bad , Bax , Bcl2 , Casp3 , Casp9 , Ctnnb1 , Gsk3b , Mapk1 , Mapk10 , Mapk3 , Mapk8 , Mapk9 , Pik3r1 , Tp53 ameloblastoma Braf amenorrhea Apc , Dcc amphetamine abuse Akt1 , Fos amyotrophic lateral sclerosis Akt1 , Bad , Bax , Bcl2 , Casp3 , Casp9 , Gsk3b , Tp53 amyotrophic lateral sclerosis type 1 Fos anaplastic astrocytoma Kras , Tp53 anaplastic thyroid carcinoma Tp53 anemia Apc , Kras Anetoderma Tgfb1 Aneurysm Smad3 Angiofibroma Ctnnb1 angiosarcoma Ccnd1 , Ctnnb1 , Jun , Kras , Myc , Tp53 Animal Disease Models Akt1 , Axin2 , Ctnnb1 , Fos , Kras , Lef1 , Mapk1 , Mapk3 , Mapk8 , Mapk9 , Myc , Rhoa , Tcf7l2 , Tgfbr1 , Tp53 Animal Mammary Neoplasms Apc , Ccnd1 , Pik3r1 anodontia Axin2 anogenital venereal wart Mapk8 , Tgfb1 anti-basement membrane glomerulonephritis Bax , Bcl2 , Mapk8 anxiety disorder Fos aortic aneurysm Smad3 , Tgfb2 , Tgfbr1 , Tgfbr2 Aortic Aneurysm, Giant Congenital Braf aortic disease Smad3 , Smad4 , Tgfb2 , Tgfbr1 aortic dissection Smad3 aortic valve disease 2 Smad3 aortic valve insufficiency Tgfb1 , Tgfb2 aphthous stomatitis Tgfb1 aplastic anemia Tgfb1 Arenaviridae infectious disease Mapk8 arrhythmogenic right ventricular cardiomyopathy Tgfb3 arrhythmogenic right ventricular dysplasia 1 Tgfb3 Arsenic Poisoning Tp53 ARTERIAL DISSECTION Smad3 arteriosclerosis Mapk9 , Tgfb1 , Tgfbr2 arteriovenous malformation Pik3ca arteriovenous malformations of the brain Braf , Kras ascending colon cancer Apc , Msh2 Asphyxia Jun asthma Bcl2 , Rhoa , Tgfb1 astroblastoma Pik3r1 ataxia telangiectasia Bax , Braf , Msh6 ataxia with oculomotor apraxia type 3 Pik3r5 atherosclerosis Akt1 , Bcl2 , Casp3 , Ccnd1 , Ctnnb1 , Myc , Tp53 atopic dermatitis Mapk8 , Tgfb1 atrial fibrillation Smad7 , Tgfb1 atrial heart septal defect 1 Tgfb2 Atrophy Mapk3 Attenuated Adenomatous Polyposis Coli Apc Attenuated Familial Adenomatous Polyposis Apc atypical teratoid rhabdoid tumor Tp53 autism spectrum disorder Apc , Ctnnb1 , Dcc , Map2k1 , Mapk1 , Mapk3 autistic disorder Apc , Bcl2 , Mapk3 , Tcf7l2 autoimmune disease Tgfb2 autoimmune hepatitis Tgfb1 autoimmune lymphoproliferative syndrome type 4 Kras autoimmune thrombocytopenic purpura Tgfb1 autosomal dominant intellectual developmental disorder 19 Ctnnb1 autosomal dominant intellectual developmental disorder 48 Rac1 autosomal dominant polycystic kidney disease Fos , Myc Autosomal Recessive Dyskeratosis Congenita Tp53 autosomal recessive dyskeratosis congenita 3 Tp53 autosomal recessive intellectual developmental disorder 74 Apc2 autosomal recessive limb-girdle muscular dystrophy type 2B Msh6 autosomal recessive limb-girdle muscular dystrophy type 2J Axin2 autosomal recessive limb-girdle muscular dystrophy type 2P Rhoa autosomal recessive polycystic kidney disease Akt1 , Myc , Pik3ca autosomal recessive progressive external ophthalmoplegia 1 Pms2 azoospermia Bcl2 B-Cell Chronic Lymphocytic Leukemia Bcl2 , Lef1 , Tp53 B-lymphoblastic leukemia/lymphoma Ccnd1 , Myc , Tcf3 , Tp53 B-lymphoblastic leukemia/lymphoma with BCR-ABL1 Msh6 bacterial infectious disease Casp3 , Casp9 bacterial pneumonia Mapk8 , Tgfb1 Balkan nephropathy Tp53 Bannayan-Riley-Ruvalcaba syndrome Pik3ca Bardet-Biedl syndrome Akt3 Bardet-Biedl syndrome 16 Akt3 basal cell carcinoma Jun , Lef1 , Pik3ca , Tgfb2 , Tp53 Behcet's disease Tgfb1 berylliosis Tgfb1 bilateral breast cancer Msh6 bile duct adenoma Braf bile duct cancer Mlh1 , Msh2 biliary atresia Tgfb1 bilirubin metabolic disorder Bcl2 Binge Drinking Fos bipolar disorder Akt1 , Gsk3b bladder urothelial carcinoma Birc5 Bloom syndrome Map2k1 , Smad3 bone development disease Tgfb2 , Tp53 bone disease Tgfbr2 Bone Fractures Tgfbr2 bone marrow disease Dcc Bone Marrow Failure Syndrome 5 Tp53 Bone Marrow Neoplasms Tp53 Bone Neoplasms Tgfbr2 bone osteosarcoma Tp53 Bowen's Disease Ccnd1 brachydactyly Smad4 Brain Contusion Casp3 brain disease Tgfb1 brain glioma Bax , Bcl2 , Birc5 , Casp3 Brain Hypoxia-Ischemia Bax , Bcl2 , Casp3 , Casp9 , Fos Brain Injuries Akt1 , Bad , Bax , Bcl2 , Birc5 , Casp3 , Fos , Gsk3b , Jun , Rhoa brain ischemia Akt1 , Bad , Bcl2 , Casp3 , Casp9 , Cycs , Jun , Map2k1 , Mapk1 , Mapk3 , Mapk8 , Tgfb1 , Tp53 Brain Neoplasms Ccnd1 , Pik3ca , Pms2 , Tgfbr2 , Tp53 breast adenocarcinoma Akt1 , Kras , Pik3ca , Tp53 breast angiosarcoma Pik3ca breast cancer Akt1 , Apc , Axin2 , Bad , Bax , Casp3 , Casp9 , Jun , Kras , Map2k1 , Mapk1 , Mlh1 , Msh2 , Msh6 , Myc , Pik3ca , Pms1 , Pms2 , Rac1 , Rhoa , Smad4 , Tcf7l2 , Tgfb1 , Tp53 Breast Cancer, Familial Akt1 , Apc , Kras , Mlh1 , Msh6 , Pik3ca , Pik3r3 , Pms2 , Tp53 breast carcinoma Apc , Birc5 , Casp3 , Mlh1 , Msh2 , Msh6 , Pik3ca , Pms2 , Rhoa , Smad2 , Tp53 Breast Neoplasms Akt1 , Akt2 , Apc2 , Bax , Bcl2 , Birc5 , Braf , Ccnd1 , Ctnnb1 , Fos , Gsk3b , Jun , Kras , Lef1 , Myc , Pik3ca , Pik3r1 , Pms2 , Raf1 , Smad4 , Tp53 bronchiolo-alveolar adenocarcinoma Ccnd1 , Kras , Tp53 bronchopulmonary dysplasia Bax , Casp3 , Casp9 , Tp53 Brugada syndrome Tgfb3 Burkitt lymphoma Myc , Pik3r1 , Tcf3 Burns Bad , Bax , Bcl2 , Casp3 , Ccnd1 , Gsk3b Cachexia Tgfb1 Cafe-au-Lait Spots Pms2 Calcification of Aortic Valve Akt1 , Tp53 calcinosis Casp3 , Ctnnb1 , Tgfb1 , Tp53 Camurati-Engelmann disease Tgfb1 cancer Braf candidiasis Mapk8 cannabis abuse Akt1 capillary hemangioma Akt3 Capillary Malformation-Arteriovenous Malformation 1 Kras , Pik3ca Carcinogenesis Akt1 , Braf , Kras carcinoma Bcl2 , Ccnd1 , Kras , Myc , Pik3r1 , Rhoa , Tgfb1 , Tgfbr2 , Tp53 carcinosarcoma Tgfb1 cardiac arrest Akt1 Cardiac Fibrosis Tgfb1 cardiofaciocutaneous syndrome Braf , Kras , Map2k1 cardiofaciocutaneous syndrome 1 Braf , Kras , Map2k1 cardiofaciocutaneous syndrome 2 Kras cardiofaciocutaneous syndrome 3 Map2k1 Cardiomegaly Akt1 , Bad , Gsk3b , Mapk1 , Mapk8 , Myc , Rac1 , Raf1 , Rhoa , Tgfb1 cardiomyopathy Akt1 , Braf , Kras , Mapk1 , Mapk3 , Tgfb3 , Tp53 Cardiotoxicity Rac1 , Tp53 Cardiovascular Abnormalities Map2k1 , Pik3ca carnitine-acylcarnitine translocase deficiency Rhoa carotid artery disease Tgfb1 , Tp53 Carotid Artery Injuries Myc , Tgfb1 , Tgfb3 , Tgfbr1 , Tgfbr2 Carpenter Syndrome 2 Akt2 , Tgfb1 cataract Casp3 , Casp9 , Map2k1 , Tp53 Caudal Duplication Anomaly Axin1 Cecal Neoplasms Ccnd1 , Ctnnb1 , Kras , Tp53 Central Nervous System Neoplasms Tp53 cerebellar medulloblastoma Msh6 Cerebral Cavernous Malformation 4 Pik3ca cerebral creatine deficiency syndrome Apc2 , Tcf3 Cerebral Hemorrhage Bax , Bcl2 , Casp3 , Casp9 cervical adenocarcinoma Tp53 cervical cancer Casp3 , Smad2 , Smad4 , Tp53 cervical squamous cell carcinoma Bax , Fos , Smad3 , Tp53 cervix uteri carcinoma in situ Bcl2 , Ccnd1 , Mlh1 , Msh2 Charcot-Marie-Tooth disease axonal type 2O Akt1 Charcot-Marie-Tooth disease dominant intermediate C Pik3r3 Charcot-Marie-Tooth disease type 2 Pik3cd CHARGE syndrome Tp53 Charlevoix-Saguenay spastic ataxia Tgfbr1 Chemical and Drug Induced Liver Injury Bad , Bax , Ctnnb1 , Tgfb1 , Tgfbr1 chemical colitis Casp3 Chemotherapy-Induced Febrile Neutropenia Tp53 childhood pilocytic astrocytoma Mapk1 chlamydia Tgfb1 Chlamydia pneumonia Pik3cd Chloracne Cycs cholangiocarcinoma Apc , Braf , Cycs , Kras , Smad4 , Tgfb1 , Tgfbr2 , Tp53 cholangitis Tgfb2 cholesteatoma of middle ear Myc , Tp53 chorioamnionitis Tgfb1 choroid plexus carcinoma Tp53 choroid plexus papilloma Tp53 chromophobe renal cell carcinoma Birc5 chromosome 16p11.2 deletion syndrome, 593-kb Mapk3 chromosome 16p11.2 duplication syndrome Mapk3 Chromosome 17 Deletion Tp53 chromosome 18q deletion syndrome Bcl2 , Smad2 , Smad7 chromosome 1p36 deletion syndrome Casp9 , Pik3cd chromosome 22q11.2 deletion syndrome, distal Mapk1 Chromosome Breakage Myc Chronic Experimental Pancreatitis Tgfb1 Chronic Hepatitis Casp3 , Smad2 , Tgfb1 Chronic Hepatitis B Tgfb1 Chronic Hepatitis C Ccnd1 , Smad4 Chronic Intermittent Hypoxia Bax , Bcl2 chronic lymphocytic leukemia Myc , Tp53 chronic mucocutaneous candidiasis Mapk8 chronic myelogenous leukemia, BCR-ABL1 positive Kras chronic myeloid leukemia Akt1 , Birc5 , Smad4 , Tgfb1 chronic obstructive pulmonary disease Casp3 , Jun , Mapk8 , Smad4 , Tgfb1 , Tp53 Chronic Pancreatitis Bad Chronic Periodontitis Rac2 Cicatrix Smad4 CLAPO Syndrome Pik3ca clear cell adenocarcinoma Bcl2 , Tp53 clear cell renal cell carcinoma Bax , Birc5 , Myc , Tp53 cleft lip Myc cleft palate Myc , Tgfb1 , Tgfb2 , Tgfb3 cleft soft palate Tgfbr2 CLOVES syndrome Pik3ca , Pik3r1 cocaine abuse Fos , Mapk1 , Mapk3 cocaine dependence Fos , Mapk1 , Mapk3 Cocaine-Related Disorders Fos , Mapk1 , Mapk3 , Rhoa , Smad3 Cockayne syndrome B Mapk8 cognitive disorder Gsk3b , Smad4 Cognitive Dysfunction Tp53 colitis Msh2 colon adenocarcinoma Apc , Bax , Bcl2 , Ctnnb1 , Mapk1 , Mapk3 , Msh6 , Pik3ca , Pik3r3 , Rac1 , Tgfb1 colon adenoma Axin2 , Ccnd1 , Rac1 colon cancer Akt1 , Akt3 , Apc , Axin1 , Bad , Bcl2 , Casp3 , Gsk3b , Mapk1 , Mlh1 , Msh2 , Pik3r2 , Pik3r5 , Pms2 , Smad2 , Smad4 , Tgfb1 , Tgfb3 , Tgfbr2 colon carcinoma Akt1 , Apc , Axin2 , Bax , Braf , Ctnnb1 , Dcc , Mlh1 , Msh2 , Msh6 , Pik3ca , Pms2 , Smad4 , Tgfb1 , Tgfb2 , Tp53 Colon Diverticulum Msh2 , Tp53 Colonic Neoplasms Apc , Axin2 , Bax , Bcl2 , Birc5 , Casp3 , Ccnd1 , Ctnnb1 , Fos , Gsk3b , Jun , Kras , Lef1 , Mapk8 , Mlh1 , Myc , Pik3r1 , Pik3r2 , Pms2 , Tcf7l2 , Tgfbr2 , Tp53 Colonic Polyps Apc , Msh2 , Pms1 , Pms2 colorectal adenocarcinoma Braf , Fos , Gsk3b , Jun , Mapk1 , Mapk3 , Mapk8 , Msh2 , Rac1 , Raf1 , Tp53 colorectal adenoma Apc , Fos , Jun , Mapk8 , Raf1 , Smad4 colorectal cancer Akt1 , Akt2 , Apc , Axin2 , Bax , Birc5 , Braf , Casp9 , Ccnd1 , Ctnnb1 , Dcc , Kras , Map2k1 , Mapk9 , Mlh1 , Msh2 , Msh6 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pms1 , Rac1 , Rhoa , Smad3 , Smad4 , Smad7 , Tcf3 , Tcf7l2 , Tgfb1 , Tgfb2 , Tgfb3 , Tgfbr1 , Tgfbr2 , Tp53 colorectal carcinoma Axin2 , Msh3 , Msh6 , Pik3ca , Rac1 , Smad4 , Tp53 Colorectal Neoplasms Akt1 , Apc , Apc2 , Axin1 , Axin2 , Bax , Bcl2 , Birc5 , Braf , Ccnd1 , Ctnnb1 , Dcc , Fos , Kras , Mapk1 , Mapk3 , Mlh1 , Msh2 , Msh6 , Myc , Pik3ca , Pik3r3 , Pms1 , Pms2 , Smad3 , Smad4 , Smad7 , Tcf7l2 , Tgfb1 , Tgfb2 , Tgfbr1 , Tp53 common variable immunodeficiency Tp53 complex cortical dysplasia with other brain malformations Akt3 , Pik3ca Complex Cortical Dysplasia with Other Brain Malformations 10 Apc2 Congenital Adrenal Hyperplasia due to 21 Hydroxylase Deficiency Msh2 congenital diaphragmatic hernia Rhoa congenital disorder of glycosylation Ii Tgfbr1 congenital disorder of glycosylation type II Tgfbr1 congenital fibrosarcoma Tp53 CONGENITAL HEART DEFECTS, MULTIPLE TYPES, 8, WITH OR WITHOUT HETEROTAXY Smad2 congenital heart disease Mapk1 , Tgfb2 congenital hypoplastic anemia Akt2 , Tgfb1 congenital hypothyroidism Fos Congenital Limb Deformities Lef1 , Tgfb2 congenital merosin-deficient muscular dystrophy 1A Tp53 congenital muscular dystrophy-dystroglycanopathy type A8 Ctnnb1 congenital myasthenic syndrome 14 Tgfbr1 congenital myasthenic syndrome 2A Tp53 congestive heart failure Bax , Bcl2 , Birc5 , Casp3 , Fos , Gsk3b , Map2k1 , Mapk10 , Rac1 , Tp53 connective tissue disease Smad3 , Tgfb2 , Tgfbr1 , Tgfbr2 contact dermatitis Bcl2 Contracture Tgfb3 Contrast-Induced Nephropathy Casp3 , Mapk8 Copper-Overload Cirrhosis Casp3 , Smad2 , Tgfb1 coronary artery disease Akt1 , Smad3 , Tgfb1 , Tp53 Coronary Disease Tcf7l2 coronary restenosis Mapk1 , Myc , Tp53 Coronavirus infectious disease Mapk1 , Mapk3 coronin-1A deficiency Mapk3 Costello syndrome Braf , Kras , Map2k1 COVID-19 Akt3 , Birc5 , Jun , Myc Cowden syndrome Pik3ca Cowden syndrome 5 Pik3ca Cowden syndrome 6 Akt1 cranioectodermal dysplasia Tgfb3 Craniofacial Abnormalities Ctnnb1 , Rhoa , Smad2 , Smad3 , Smad4 , Tgfb2 , Tgfbr2 , Tp53 CRANIOMETADIAPHYSEAL OSTEOSCLEROSIS WITH HIP DYSPLASIA Axin1 craniopharyngioma Apc , Braf , Ctnnb1 craniosynostosis Axin2 , Tgfbr1 craniosynostosis 1 Akt2 , Tgfb1 Craniosynostosis Syndrome, Autosomal Recessive Axin2 , Tgfbr1 Crohn's disease Smad3 , Tcf7 Cronkhite-Canada syndrome Smad4 cryptorchidism Casp3 Currarino syndrome Pik3ca cutaneous leishmaniasis Pik3cd cutaneous Paget's disease Pik3ca Cyanosis Tgfb2 cyclic hematopoiesis Apc2 , Tcf3 cystic fibrosis Tgfb1 Dandy-Walker syndrome Braf Deafness Smad4 degenerative disc disease Fos , Gsk3b , Tgfb1 dementia Bax , Bcl2 demyelinating disease Mapk1 , Myc , Tp53 dengue disease Mapk8 depressive disorder Bax , Fos , Gsk3b , Jun , Mapk1 dermatomyositis Pms1 desmoid tumor Apc , Ctnnb1 developmental and epileptic encephalopathy Pik3r3 developmental and epileptic encephalopathy 14 Ralgds developmental and epileptic encephalopathy 54 Akt3 Developmental Disabilities Akt3 , Braf , Ctnnb1 , Mapk3 , Mlh1 , Pik3ca , Pik3r2 , Rac1 Developmental Disease Ctnnb1 , Rac1 , Tgfb3 Diabetes Complications Casp9 diabetes mellitus Casp3 , Rac1 , Tcf7l2 , Tgfb1 diabetic angiopathy Casp3 Diabetic Cardiomyopathies Akt1 , Bad , Bax , Bcl2 , Casp3 , Casp9 , Ctnnb1 , Mapk1 , Mapk3 , Pik3ca Diabetic Cystopathy Bad diabetic encephalopathy Gsk3b Diabetic Nephropathies Casp3 , Casp9 , Gsk3b , Mapk1 , Rhoa , Tcf7l2 , Tgfb1 , Tgfbr2 , Tp53 diabetic neuropathy Bad , Casp3 , Tgfb1 , Tgfb2 , Tgfb3 diabetic retinopathy Akt1 , Casp3 , Casp9 , Tgfbr2 Diamond-Blackfan anemia Akt2 , Tgfb1 , Tp53 diaphragmatic eventration Pik3ca Diaphragmatic Hernia Tgfb1 diffuse large B-cell lymphoma Bcl2 , Braf , Myc , Pik3ca , Pik3cb , Pik3cd , Pms2 , Tp53 diffuse pediatric-type high-grade glioma, H3-wildtype and IDH-wildtype Pms2 , Tp53 diffuse scleroderma Tgfbr1 DiGeorge syndrome Mapk1 , Tgfbr2 , Tp53 Digestive System Neoplasms Apc , Msh3 , Msh6 Dilatation, Pathologic Tgfb1 dilated cardiomyopathy Axin2 , Bax , Bcl2 , Braf , Casp3 , Casp9 , Ctnnb1 , Gsk3b , Kras , Lef1 , Mapk3 , Rac1 , Raf1 , Tcf7l2 , Tgfb3 , Tp53 dilated cardiomyopathy 1B Raf1 dilated cardiomyopathy 1G Pms2 dilated cardiomyopathy 1NN Raf1 Dilated Cardiomyopathy with Left Ventricular Noncompaction Raf1 disease of cellular proliferation Kras , Myc , Tp53 Disease Progression Bcl2 , Ccnd1 , Ctnnb1 , Kras , Myc , Pik3ca , Rac2 , Tp53 Disproportionate Tall Stature Tgfbr1 Dissecting Aneurysm Smad3 , Tgfbr1 , Tgfbr2 Down syndrome Pik3ca Drug-Induced Dyskinesia Gsk3b Drug-induced Neutropenia Tp53 Drug-Related Side Effects and Adverse Reactions Tp53 dry eye syndrome Tgfb1 Duchenne muscular dystrophy Tgfb1 Ductal Carcinoma Myc , Tp53 ductal carcinoma in situ Bcl2 , Birc5 , Ccnd1 , Tp53 duodenal ulcer Tgfb1 duodenum adenocarcinoma Apc Dwarfism Mapk1 , Tp53 dysembryoplastic neuroepithelial tumor Braf dyskeratosis congenita Tp53 dysplastic nevus syndrome Braf early infantile epileptic encephalopathy Pik3r3 ectodermal dysplasia Rhoa ECTODERMAL DYSPLASIA WITH FACIAL DYSMORPHISM AND ACRAL, OCULAR, AND BRAIN ANOMALIES Rhoa Edema Casp3 , Casp9 Ehlers-Danlos syndrome Smad3 , Tgfb1 , Tgfb2 , Tgfbr1 , Tgfbr2 Ehlers-Danlos syndrome classic type 1 Ralgds , Tgfbr1 Emery-Dreifuss muscular dystrophy Rac2 Emphysema Tp53 Encephalocraniocutaneous Lipomatosis Kras end stage renal disease Bcl2 , Tgfb1 endodermal sinus tumor Ctnnb1 endometrial adenocarcinoma Axin2 , Jun , Kras , Mapk1 , Mapk3 , Pik3r1 , Tp53 endometrial cancer Akt2 , Apc , Bad , Msh3 , Msh6 , Pik3cb , Pik3cd , Pik3r1 , Smad2 , Smad3 , Smad7 , Tp53 endometrial carcinoma Apc , Braf , Gsk3b , Jun , Kras , Mapk1 , Mapk3 , Mlh1 , Msh2 , Msh3 , Msh6 , Pik3ca , Pik3r1 , Pms2 , Smad4 , Tp53 endometrial hyperplasia Birc5 , Kras Endometrial Hyperplasia without Atypia Kras Endometrial Intraepithelial Neoplasia Apc , Ctnnb1 , Kras , Tp53 Endometrial Neoplasms Apc , Bcl2 , Birc5 , Ccnd1 , Ctnnb1 , Gsk3b , Kras , Mapk3 , Mlh1 , Msh2 , Msh3 , Msh6 , Myc , Pik3ca , Pik3cb , Tp53 endometrial serous adenocarcinoma Msh6 Endometrioid Carcinomas Apc , Birc5 , Ctnnb1 , Kras , Mapk1 , Mapk3 endometriosis Bax , Bcl2 , Birc5 , Ctnnb1 , Fos , Kras , Mapk8 , Tgfb2 endometritis Casp3 , Casp9 endomyocardial fibrosis Tgfb1 Endotoxemia Akt1 , Bax , Bcl2 , Casp3 , Casp9 , Mapk8 eosinophilic esophagitis Tgfb1 epidermal nevus Kras , Pik3ca epilepsy Akt1 , Apc2 , Axin1 , Fos , Pik3r2 , Tgfb1 Episodic Kinesigenic Dyskinesia Mapk3 episodic kinesigenic dyskinesia 1 Mapk3 esophageal cancer Akt1 , Dcc , Pik3ca , Tgfbr2 , Tp53 esophageal carcinoma Akt1 , Dcc , Pik3ca , Smad4 , Tp53 Esophageal Neoplasms Bax , Bcl2 , Ccnd1 , Dcc , Myc , Tgfbr2 , Tp53 esophagus adenocarcinoma Bcl2 , Pik3ca , Smad4 , Tp53 esophagus squamous cell carcinoma Akt1 , Axin1 , Ccnd1 , Dcc , Mlh1 , Msh2 , Tgfbr2 , Tp53 essential thrombocythemia Tgfb1 estrogen-receptor positive breast cancer Pik3ca Experimental Allergic Asthma Bcl2 Experimental Arthritis Akt1 , Bax , Bcl2 , Fos , Gsk3b , Pik3cd , Tgfb1 , Tgfbr2 Experimental Autoimmune Encephalomyelitis Casp3 , Casp9 , Rhoa , Tgfb1 , Tgfb2 Experimental Autoimmune Myocarditis Casp3 , Casp9 Experimental Autoimmune Neuritis Dcc , Rhoa Experimental Colitis Akt1 , Bcl2 , Mapk1 , Mapk3 , Smad4 Experimental Diabetes Mellitus Akt1 , Bad , Bax , Bcl2 , Casp3 , Casp9 , Mapk1 , Mapk3 , Myc , Pik3r1 , Rhoa , Tgfb1 , Tgfb2 , Tp53 Experimental Liver Cirrhosis Akt1 , Appl1 , Bcl2 , Birc5 , Fos , Mapk1 , Mapk3 , Myc , Rac2 , Rhoa , Smad2 , Smad3 , Smad4 , Tgfb1 , Tgfb3 , Tgfbr1 , Tgfbr2 Experimental Liver Neoplasms Bcl2 , Birc5 , Ccnd1 , Ctnnb1 , Kras , Map2k1 , Mapk1 , Mapk3 , Myc , Tgfb1 , Tp53 Experimental Mammary Neoplasms Akt1 , Akt2 , Bad , Bax , Bcl2 , Casp3 , Casp9 , Ccnd1 , Ctnnb1 , Gsk3b , Mapk1 , Mapk3 , Myc , Pik3r1 , Tgfb1 , Tgfbr1 , Tgfbr2 , Tp53 Experimental Melanoma Braf Experimental Neoplasms Braf , Ccnd1 , Ctnnb1 , Kras , Tp53 Experimental Radiation Injuries Casp3 , Casp9 , Mapk1 , Mapk3 Experimental Sarcoma Kras Experimental Seizures Bad , Ccnd1 , Msh2 extrahepatic bile duct adenocarcinoma Rac1 extrahepatic cholestasis Fos , Jun , Mapk1 , Mapk3 , Mapk8 , Mapk9 , Tgfb1 exudative vitreoretinopathy Ctnnb1 exudative vitreoretinopathy 1 Ctnnb1 exudative vitreoretinopathy 7 Ctnnb1 Eye Abnormalities Apc , Tgfb2 , Tgfbr2 Eye Neoplasms Tp53 Facial Asymmetry Pik3ca factor VIII deficiency Tgfb1 familial adenomatous polyposis Akt1 , Apc , Axin2 , Msh3 familial adenomatous polyposis 1 Apc , Tcf7 familial adenomatous polyposis 4 Msh3 Familial Horizontal Gaze Palsy with Progressive Scoliosis Dcc Familial Horizontal Gaze Palsy with Progressive Scoliosis, 2 Dcc familial hyperlipidemia Apc , Tgfb1 familial hypertrophic cardiomyopathy Raf1 familial melanoma Braf , Tp53 familial multiple nevi flammei Pik3ca Familial Pancreatic Carcinoma Kras , Smad4 , Tp53 familial partial lipodystrophy Akt2 Familial Prostate Cancer Bcl2 , Map2k1 , Msh6 , Tcf7l2 Familial Thoracic Aortic Aneurysm 1 Smad3 , Tgfbr2 Familial Thoracic Aortic Aneurysm 6 Smad3 , Tgfbr1 Fatigue Tgfbr2 Female Infertility Mapk1 , Mapk3 , Tp53 female reproductive system disease Smad2 Femoral Fractures Lef1 Ferguson-Smith tumor Tgfbr1 fetal alcohol syndrome Rhoa Fetal Growth Retardation Bax , Bcl2 , Casp3 , Fos fibrillary astrocytoma Kras fibrolamellar carcinoma Ctnnb1 Fibrosis Akt1 , Ctnnb1 , Rhoa , Tgfb1 Fibrous Dysplasia of Bone Fos focal segmental glomerulosclerosis Casp9 , Tgfb1 focal segmental glomerulosclerosis 5 Akt1 follicular lymphoma Bcl2 Follicular Thyroid Cancer Braf follicular thyroid carcinoma Kras functional diarrhea Fos Funnel Chest Tp53 gallbladder cancer Apc , Axin2 , Braf , Ctnnb1 , Kras , Pik3ca , Smad4 , Tp53 gallbladder carcinoma Rac1 Gallbladder Neoplasms Apc , Bcl2 , Kras , Tgfb1 , Tp53 Gallstones Smad4 ganglioglioma Braf Gardner Syndrome Apc gastric adenocarcinoma Braf , Pik3ca , Rac1 , Tp53 Gastric Adenocarcinoma and Proximal Polyposis of the Stomach Apc Gastric Polyposis Apc gastric ulcer Bad , Bcl2 , Casp3 , Fos , Mapk1 , Mapk3 Gastrointestinal Hemorrhage Apc , Bax Gastrointestinal Neoplasms Apc , Pik3ca gastrointestinal stromal tumor Akt3 , Apc , Braf , Kras , Msh3 , Tgfb2 , Tgfbr2 gastrointestinal system cancer Smad4 Gaucher's disease Msh6 Gaucher's disease type I Msh6 Generalized Epilepsy Mapk10 genetic disease Akt1 , Akt2 , Akt3 , Apc2 , Bax , Braf , Ctnnb1 , Dcc , Kras , Map2k1 , Mapk1 , Msh6 , Pik3ca , Pik3cd , Pik3r1 , Pik3r2 , Rac1 , Rac2 , Raf1 , Rhoa , Smad2 , Tcf3 , Tcf7l2 , Tgfb1 , Tgfb2 , Tgfbr2 Genetic Predisposition to Disease Msh6 Genomic Instability Ccnd1 Germ Cell and Embryonal Neoplasms Birc5 , Mlh1 , Msh2 , Rhoa germinoma Braf gestational diabetes Tcf7l2 glaucoma Bad , Bax , Bcl2 , Jun , Tgfb2 glioblastoma Akt1 , Akt3 , Apc , Kras , Msh2 , Myc , Pik3ca , Pik3cb , Pik3cd , Tp53 Gliosis Mapk1 , Mapk3 glomerulonephritis Fos , Mapk1 glucose intolerance Pik3r1 glycine encephalopathy Rhoa glycogen storage disease II Pik3ca Glycogen Storage Disease XII Mapk3 GM1 gangliosidosis Msh6 GM1 gangliosidosis type 1 Msh6 gout Tgfb1 graft-versus-host disease Tp53 granulosa cell tumor Ctnnb1 Graves' disease Tgfb1 , Tp53 Growth Disorders Pik3ca Growth Mental Deficiency Syndrome of Myhre Smad4 hairy cell leukemia Map2k1 Head and Neck Neoplasms Bcl2 , Mapk1 , Mapk3 head and neck squamous cell carcinoma Akt1 , Braf , Ccnd1 , Ctnnb1 , Pik3ca , Smad4 , Tp53 Hearing Loss, Cisplatin-Induced Gsk3b heart disease Bax , Casp3 , Casp9 , Gsk3b , Rac2 , Tgfb1 Heart Injuries Tgfb1 heart valve disease Casp3 Heat Stroke Fos , Jun Helicobacter Infections Mapk8 hematologic cancer Tp53 Hematuria Fos Hemifacial Myohyperplasia Pik3ca Hemimegalencephaly Pik3ca hemolytic-uremic syndrome Fos Hemorrhage Fos hemorrhagic disease Cycs , Smad4 Hemorrhagic Shock Bad , Bcl2 , Casp3 , Mapk1 , Myc , Tgfb1 hepatic encephalopathy Tgfb1 Hepatic Insufficiency Tgfb1 hepatitis Mapk8 , Mapk9 hepatitis B Ctnnb1 hepatitis C Myc hepatoblastoma Apc , Axin2 , Ctnnb1 , Msh2 , Msh6 , Tgfbr2 , Tp53 hepatocellular adenoma Ctnnb1 , Kras hepatocellular carcinoma Akt1 , Akt2 , Apc , Axin1 , Axin2 , Bax , Bcl2 , Birc5 , Braf , Casp3 , Casp9 , Ccnd1 , Ctnnb1 , Fos , Jun , Kras , Mapk1 , Mapk8 , Msh3 , Myc , Pik3ca , Pik3cb , Pik3r1 , Pik3r2 , Pik3r3 , Pms2 , Rac1 , Smad2 , Smad4 , Smad7 , Tgfb1 , Tgfb2 , Tgfbr2 , Tp53 Hepatomegaly Akt1 , Tgfb1 Hereditary Adrenocortical Carcinoma Tp53 hereditary breast ovarian cancer syndrome Apc , Kras , Mlh1 , Msh2 , Msh6 , Pms1 , Pms2 , Raf1 , Ralgds , Smad4 , Smad7 , Tp53 hereditary desmoid disease Apc , Ctnnb1 hereditary diffuse gastric cancer Kras hereditary hemorrhagic telangiectasia Smad4 Hereditary Hemorrhagic Telangiectasia, Type 1 Smad4 , Tgfb1 Hereditary Neoplastic Syndromes Akt1 , Apc , Axin2 , Mlh1 , Msh2 , Msh3 , Msh6 , Pik3ca , Pms2 , Smad4 , Tcf7 , Tp53 hereditary nonpolyposis colorectal cancer type 2 Mlh1 , Msh2 hereditary nonpolyposis colorectal cancer type 4 Msh2 , Msh6 , Pms2 hereditary nonpolyposis colorectal cancer type 5 Msh6 , Pms2 hereditary nonpolyposis colorectal cancer type 6 Tgfbr2 Hereditary Pancreatitis Casp9 heroin dependence Akt1 , Ctnnb1 Herpes Simplex Encephalitis 3 Akt1 Heterotopic Ossification Smad4 high grade glioma Akt2 , Apc , Bad , Birc5 , Braf , Ccnd1 , Kras , Map2k1 , Mapk3 , Msh2 , Pik3ca , Pik3r3 , Raf1 , Tp53 Hirschsprung Disease 1 Tgfb2 Hirschsprung's disease Axin2 , Tgfb2 Hodgkin's lymphoma Jun , Kras , Mapk1 , Myc Holt-Oram syndrome Tgfb2 human immunodeficiency virus infectious disease Bax Human Viral Hepatitis Smad4 Huntington's disease Bax , Bcl2 , Casp3 , Casp9 , Cycs , Msh2 Hydatidiform Mole Mlh1 , Msh2 Hydatidiform Mole, Invasive Msh2 hydrocephalus Mlh1 Hydrops Fetalis Kras Hyperalgesia Fos , Mapk1 , Mapk3 , Mapk8 , Mapk9 , Raf1 , Tcf7l2 , Tgfbr1 Hypercholesterolemia Casp3 , Casp9 hyperekplexia Ctnnb1 Hyperkinesis Fos Hyperoxia Tgfb1 hyperparathyroidism Ccnd1 , Myc Hyperplasia Akt1 , Apc , Bax , Ccnd1 , Pik3ca , Tcf7l2 , Tgfb1 , Tgfbr2 Hypertelorism Pik3ca hypertension Akt1 , Akt2 , Bad , Bax , Bcl2 , Casp3 , Casp9 , Fos , Gsk3b , Jun , Kras , Mapk8 , Pik3r1 , Rhoa , Tgfb1 , Tgfb3 , Tp53 Hypertriglyceridemia Akt1 hypertrophic cardiomyopathy Bcl2 , Braf , Casp3 , Ctnnb1 , Myc , Raf1 , Tgfb1 , Tgfb3 , Tp53 hypertrophic cardiomyopathy 1 Raf1 hypertrophic cardiomyopathy 4 Braf hypertrophic cardiomyopathy 9 Pms2 Hypertrophy Mapk1 , Mapk3 hyperuricemia Tgfb1 Hypoglossal Nerve Injuries Smad2 , Smad3 , Smad4 , Smad7 hypoglycemia Akt2 , Pik3r1 Hypogonadism and Testicular Atrophy Tp53 hypoinsulinemic hypoglycemia with hemihypertrophy Akt2 hypomyelinating leukodystrophy 7 Tgfbr2 Hypopigmentation Rhoa hypospadias Fos Hypothermia Bcl2 hypothyroidism Bad Hypoxia Casp3 idiopathic generalized epilepsy Axin1 , Birc5 idiopathic pulmonary fibrosis Akt1 , Smad2 IgA glomerulonephritis Tgfb1 Immunoblastic Lymphadenopathy Rhoa immunodeficiency 14 Pik3cd , Pik3r1 immunodeficiency 31B Pms1 immunodeficiency 36 Pik3r1 immunodeficiency 73a with defective neutrophil chemotaxis and leukocytosis Rac2 immunodeficiency 73b with defective neutrophil chemotaxis and lymphopenia Rac2 immunodeficiency 73c with defective neutrophil chemotaxis and hypogammaglobulinemia Rac2 imperforate anus Ctnnb1 impotence Akt1 , Bad , Bax , Bcl2 , Casp3 , Ccnd1 , Tgfb1 in situ carcinoma Akt1 , Ctnnb1 Infant, Newborn, Diseases Tgfb1 Infectious Ectromelia Mapk8 Inflammation Akt1 , Tgfb1 inflammatory bowel disease Apc , Apc2 , Tgfb1 INFLAMMATORY BOWEL DISEASE, IMMUNODEFICIENCY, AND ENCEPHALOPATHY Tgfb1 influenza A Mapk8 inguinal hernia Tgfbr2 Inhalant Abuse Fos Insulin Resistance Akt2 , Bad , Casp3 , Mapk3 , Pik3r1 , Tcf7l2 insulinoma Tgfb1 INTELLECTUAL DEVELOPMENTAL DISORDER WITH DYSMORPHIC FACIES AND BEHAVIORAL ABNORMALITIES Msh6 intellectual disability Apc , Bad , Braf , Ccnd1 , Ctnnb1 , Dcc , Fos , Kras , Mapk1 , Pik3r2 , Ralgds , Smad2 , Smad4 , Smad7 , Tcf7l2 , Tgfb3 , Tgfbr1 intermediate coronary syndrome Akt1 intermittent claudication Bad , Bax , Casp3 interstitial cystitis Ccnd1 interstitial lung disease Tgfb1 Intervertebral Disc Displacement Akt1 intestinal disease Bax , Bcl2 , Casp3 Intestinal Neoplasms Apc , Bax , Bcl2 , Ctnnb1 , Gsk3b , Mapk8 Intestinal Polyps Apc , Axin2 , Ccnd1 , Jun , Mlh1 Intestinal Reperfusion Injury Casp3 , Casp9 Intimal Hyperplasia Mapk1 intracranial aneurysm Bcl2 intrahepatic cholangiocarcinoma Apc , Braf , Kras , Smad4 invasive ductal carcinoma Akt1 , Smad4 invasive lobular carcinoma Ccnd1 , Ctnnb1 irritable bowel syndrome Fos ischemia Akt2 , Bax , Cycs , Mapk9 , Raf1 , Tp53 Jaw Neoplasms Apc Joubert syndrome 1 Tgfb1 Joubert syndrome 9 Msh6 juvenile myelomonocytic leukemia Kras , Rac2 juvenile polyposis syndrome Smad4 juvenile polyposis-hereditary hemorrhagic telangiectasia syndrome Smad4 juvenile rheumatoid arthritis Fos , Jun , Kras , Mapk1 , Smad3 , Tcf7l2 Kaposi's sarcoma Tp53 Kashin-Beck Disease Bax , Bcl2 keratoacanthoma Pik3ca keratosis Tp53 kidney disease Apc , Casp3 , Casp9 , Mapk1 , Tgfb1 , Tgfbr1 , Tgfbr2 Kidney Neoplasms Akt1 , Birc5 , Braf , Ccnd1 , Kras , Mapk1 , Mapk3 , Raf1 Kidney Reperfusion Injury Bax , Bcl2 , Casp3 , Fos , Myc , Tgfb1 Klatskin's tumor Apc , Kras Klippel-Trenaunay syndrome Pik3ca Knee Osteoarthritis Bax , Bcl2 , Ctnnb1 Kuhnt-Junius degeneration Mapk8 Langerhans-cell histiocytosis Braf laryngeal squamous cell carcinoma Mlh1 , Msh2 learning disability Bcl2 Leber congenital amaurosis Braf Leber hereditary optic neuropathy Tp53 Left Ventricular Hypertrophy Ctnnb1 , Mapk1 , Myc , Rac1 , Rhoa left ventricular noncompaction Tgfb3 Leigh disease Ralgds leiomyoma Bax , Bcl2 , Myc , Smad3 , Tgfbr1 Lennox-Gastaut syndrome Mapk10 leukemia Bad , Ccnd1 , Tp53 leukocyte adhesion deficiency 3 Bad Leukocytosis Apc , Kras Leukoencephalopathies Rhoa Li-Fraumeni syndrome Tp53 Li-Fraumeni syndrome 1 Tp53 Li-Fraumeni-Like Syndrome Tp53 linear nevus sebaceous syndrome Kras Lip Neoplasms Tp53 listeriosis Pik3cd liver cancer Ccnd1 , Pik3ca liver cirrhosis Axin1 , Casp3 , Casp9 , Ctnnb1 , Myc , Smad3 , Smad7 , Tgfb1 , Tgfb2 , Tgfbr1 liver disease Apc , Rac1 Liver Injury Myc Liver Metastasis Braf , Smad4 Liver Neoplasms Apc , Braf , Ccnd1 , Ctnnb1 , Jun , Kras , Myc , Raf1 , Tp53 Liver Reperfusion Injury Bad , Bax , Bcl2 , Casp3 , Casp9 , Gsk3b , Mapk8 localized scleroderma Tgfb1 Loeys-Dietz syndrome Smad2 , Smad3 , Tgfb2 , Tgfb3 , Tgfbr1 , Tgfbr2 Loeys-Dietz syndrome 1 Tgfbr1 , Tgfbr2 Loeys-Dietz syndrome 2 Tgfbr2 Loeys-Dietz syndrome 3 Smad3 Loeys-Dietz syndrome 4 Tgfb2 , Tgfb3 Loeys-Dietz syndrome 5 Tgfb3 Loeys-Dietz syndrome 6 Smad2 Loeys-Dietz Syndrome, Type 1b Tgfbr2 long QT syndrome Braf , Ccnd1 , Tgfb3 long QT syndrome 1 Braf low tension glaucoma Tp53 lung adenocarcinoma Apc , Axin2 , Birc5 , Braf , Ccnd1 , Ctnnb1 , Kras , Map2k1 , Mlh1 , Msh2 , Msh3 , Msh6 , Myc , Pik3ca , Pik3r1 , Rac1 , Raf1 , Smad4 , Tgfb2 , Tp53 lung cancer Axin1 , Axin2 , Braf , Ctnnb1 , Kras , Mlh1 , Msh2 , Msh3 , Myc , Pik3ca , Rac1 , Smad3 , Smad4 lung carcinoma Braf , Ctnnb1 , Kras , Mlh1 , Pik3ca lung disease Tgfb1 Lung Injury Bax , Bcl2 Lung Neoplasms Akt1 , Apc , Birc5 , Braf , Ccnd1 , Ctnnb1 , Fos , Jun , Kras , Mapk1 , Mapk3 , Myc , Pik3ca , Raf1 , Tgfb1 , Tgfbr2 , Tp53 lung non-small cell carcinoma Akt1 , Akt3 , Apc , Axin1 , Bad , Bax , Birc5 , Braf , Casp3 , Casp9 , Ccnd1 , Cycs , Kras , Map2k1 , Mlh1 , Msh2 , Msh3 , Myc , Pik3ca , Raf1 , Smad3 , Tp53 Lung Reperfusion Injury Bax , Bcl2 , Casp3 , Kras , Myc lung sarcomatoid carcinoma Kras , Msh6 , Tp53 lung small cell carcinoma Axin2 , Bcl2 , Ccnd1 , Myc , Pik3ca , Pik3r1 , Tp53 lung squamous cell carcinoma Birc5 , Braf , Ccnd1 , Ctnnb1 , Cycs , Kras , Map2k1 , Pik3ca , Tp53 Lymphangiectasis Raf1 lymphangioma Braf , Pik3ca Lymphatic Metastasis Bcl2 , Birc5 , Braf , Casp9 , Ctnnb1 , Cycs , Msh2 , Pik3ca , Pik3cb , Rhoa , Smad4 , Tp53 lymphoma Kras , Mlh1 , Rac2 , Tp53 Lymphomatoid Papulosis Tgfb1 Lynch syndrome Apc , Kras , Mlh1 , Msh2 , Msh6 , Pms1 , Pms2 , Smad2 , Smad3 , Smad4 , Tgfbr1 , Tgfbr2 Lynch syndrome 1 Mlh1 , Msh2 , Msh6 , Pms1 , Pms2 Macrocephaly Akt3 , Pik3ca Macrocephaly Mesodermal Hamartoma Spectrum Akt1 macrocytic anemia Apc macular degeneration Bad , Bax male infertility Bax , Bcl2 , Tp53 malignant astrocytoma Akt1 , Akt2 , Akt3 , Braf , Ccnd1 , Kras , Tp53 malignant mesothelioma Bcl2 , Ctnnb1 , Raf1 , Tgfb2 , Tp53 malignant pleural mesothelioma Birc5 , Mlh1 Mandibular Neoplasms Braf , Ctnnb1 mantle cell lymphoma Ccnd1 , Ctnnb1 , Gsk3b , Pik3cd maple syrup urine disease Akt2 , Tgfb1 Marfan syndrome Tgfbr1 , Tgfbr2 Marfan Syndrome Type 2 Tgfbr2 Marfanoid Hypermobility Syndrome Tgfbr1 , Tgfbr2 marginal zone lymphoma Tp53 Martsolf Syndrome Tgfb2 maturity-onset diabetes of the young type 1 Akt2 , Tcf7l2 maturity-onset diabetes of the young type 14 Appl1 Meckel Syndrome 10 Tgfb1 medulloblastoma Apc , Ccnd1 , Ctnnb1 , Myc , Pik3ca , Tp53 megacolon Akt3 , Mapk8 Megalencephaly - Cutis Marmorata Telangiectatica Congenita Akt3 , Pik3ca , Pik3r1 , Pik3r2 Megalencephaly-Polymicrogyria-Polydactyly-Hydrocephalus Syndrome Akt3 , Pik3ca , Pik3r2 Megalencephaly-Polymicrogyria-Polydactyly-Hydrocephalus Syndrome 1 Pik3r2 Megalencephaly-Polymicrogyria-Polydactyly-Hydrocephalus Syndrome 2 Akt3 Megaloblastic Anemia due to Dihydrofolate Reductase Deficiency Msh3 Megalodactyly Pik3ca melanoma Bcl2 , Braf , Dcc , Map2k1 , Mapk1 , Pik3ca , Rac1 , Rac2 , Tp53 melorheostosis Map2k1 membranoproliferative glomerulonephritis Tgfbr2 membranous glomerulonephritis Rhoa Memory Disorders Akt1 , Bcl2 , Mapk1 , Mapk3 meninges sarcoma Tp53 meningioma Akt1 Mercury Poisoning, Nervous System Jun Merkel cell carcinoma Myc mesenchymal chondrosarcoma Bcl2 Mesothelioma Apc , Birc5 , Tp53 metabolic dysfunction and alcohol associated liver disease Akt1 , Tgfb1 metabolic dysfunction-associated steatohepatitis Akt1 , Smad4 metabolic dysfunction-associated steatotic liver disease Akt1 , Mapk8 , Tgfb1 Metabolic Syndrome Tgfb1 Metaplasia Axin2 , Bcl2 , Ctnnb1 methylmalonic acidemia Cycs methylmalonic aciduria due to methylmalonyl-CoA mutase deficiency Tgfbr1 Microcephaly, Epilepsy, and Diabetes Syndrome Smad2 Microphthalmia, Cataracts, and Iris Abnormalities Smad4 Microsatellite Instability Bax , Braf , Msh3 , Msh6 , Tgfbr2 middle cerebral artery infarction Bad , Bax , Bcl2 , Casp3 , Casp9 , Fos , Gsk3b , Mapk1 , Mapk3 , Tgfb1 migraine Fos , Tgfbr2 Mirror Movements 1 Dcc mismatch repair cancer syndrome Apc , Mlh1 , Msh2 , Msh6 , Pms2 , Tgfbr2 , Tp53 Mismatch Repair Cancer Syndrome 1 Mlh1 , Msh2 , Msh6 , Pms2 Mismatch Repair Cancer Syndrome 2 Msh2 Mismatch Repair Cancer Syndrome 3 Msh6 Mismatch Repair Cancer Syndrome 4 Pms2 mitochondrial metabolism disease Tp53 Monoclonal B-Cell Lymphocytosis Apc morphine dependence Bax , Bcl2 , Fos , Mapk1 , Mapk3 morphine withdrawal syndrome Bad , Fos Mouth Neoplasms Kras , Pik3ca , Tp53 Muir-Torre syndrome Mlh1 , Msh2 Multi-Infarct Dementia Bax , Bcl2 multicentric Castleman disease Tcf3 Multiple Abnormalities Ctnnb1 , Gsk3b , Kras multiple acyl-CoA dehydrogenase deficiency Tgfbr2 multiple congenital anomalies-hypotonia-seizures syndrome 1 Bcl2 multiple endocrine neoplasia type 1 Bad multiple myeloma Bcl2 , Braf , Ccnd1 , Kras , Pik3r2 , Tcf3 , Tgfb1 , Tp53 Multiple Organ Failure Mapk1 Multiple Primary Neoplasms Mlh1 multiple sclerosis Rhoa muscular atrophy Akt1 , Ctnnb1 , Gsk3b , Kras muscular disease Smad4 , Tgfb1 Musculoskeletal Abnormalities Tgfb2 Mycoplasma Infections Casp3 Mycoplasma pneumoniae pneumonia Tcf7 myelodysplastic syndrome Kras , Myc , Tp53 myelofibrosis Tgfb1 , Tp53 myeloid leukemia associated with Down Syndrome Tp53 myeloid neoplasm Kras , Tp53 myeloid sarcoma Kras myeloproliferative neoplasm Tcf3 myocardial infarction Akt1 , Bax , Bcl2 , Birc5 , Casp3 , Fos , Gsk3b , Mapk1 , Mapk8 , Smad2 , Smad3 , Smad4 , Tgfb1 , Tgfb2 , Tgfbr1 , Tgfbr2 , Tp53 Myocardial Ischemia Axin2 , Bax , Bcl2 , Ccnd1 , Ctnnb1 , Tcf7l2 Myocardial Reperfusion Injury Akt1 , Akt2 , Bad , Bax , Bcl2 , Casp3 , Casp9 , Gsk3b , Mapk1 , Mapk3 , Mapk8 , Rhoa , Smad3 , Smad4 , Tgfb1 , Tp53 myoclonic dystonia 26 Rac2 Myoectodermal Gonadal Dysgenesis Syndrome Pik3ca myoepithelioma Braf , Tgfbr1 nasal cavity cancer Tp53 Nasal Polyps Jun , Tgfb1 Nasopharyngeal Neoplasms Ccnd1 , Tp53 nasopharynx carcinoma Bcl2 , Rac1 , Tp53 NATURAL KILLER CELL ENTEROPATHY Pik3cb Necrosis Bcl2 Nematode Infections Pik3r1 Neointima Akt1 Neonatal Hypoglycemia, Simulating Foetopathia Diabetica Akt2 Neoplasm Invasiveness Ctnnb1 , Lef1 , Mapk1 , Mapk3 , Rhoa , Tgfb1 Neoplasm Metastasis Akt2 , Bax , Bcl2 , Braf , Casp3 , Ccnd1 , Ctnnb1 , Kras , Lef1 , Mapk1 , Mapk3 , Mapk9 , Mlh1 , Msh2 , Myc , Pik3ca , Pik3r3 , Pms2 , Rac1 , Rhoa , Smad4 , Tcf3 , Tgfb1 , Tgfbr1 , Tgfbr2 , Tp53 Neoplasm Micrometastasis Cycs Neoplastic Cell Transformation Apc , Bcl2 , Ccnd1 , Ctnnb1 , Fos , Gsk3b , Jun , Kras , Mapk8 , Myc , Rac1 , Tgfb1 , Tp53 nephritis Smad7 nephroblastoma Braf , Ctnnb1 , Myc , Smad4 , Tp53 nephrolithiasis Tgfb1 nephronophthisis Tgfbr1 nephrosclerosis Tgfb1 nephrotic syndrome Tgfb1 nephrotoxicity Tgfb1 Nerve Degeneration Bax , Bcl2 , Casp3 , Ctnnb1 , Mapk1 , Mapk3 Nerve Sheath Neoplasms Tp53 nervous system disease Casp3 , Casp9 , Fos , Tp53 Nervous System Malformations Ctnnb1 Neuralgia Tgfb1 neuroblastoma Kras , Myc , Tp53 Neurocutaneous Syndromes Rhoa neurodegeneration with brain iron accumulation 2A Rac2 neurodevelopmental disorder with dysmorphic facies and distal limb anomalies Rac1 NEURODEVELOPMENTAL DISORDER WITH MICROCEPHALY, ARTHROGRYPOSIS, AND STRUCTURAL BRAIN ANOMALIES Pik3ca Neurodevelopmental Disorders Akt3 , Apc , Apc2 , Ctnnb1 , Mapk3 , Msh3 , Msh6 , Pik3cd , Pik3r1 , Pms1 , Tcf3 , Tcf7 , Tcf7l2 neuroectodermal tumor Myc neuroendocrine tumor Braf neuronal ceroid lipofuscinosis Map2k1 , Smad3 neuronal ceroid lipofuscinosis 6A Gsk3b , Mapk1 , Mapk3 Nevus Braf newborn respiratory distress syndrome Braf nicotine dependence Apc2 , Fos No-Reflow Phenomenon Ctnnb1 Nociceptive Pain Fos non-Hodgkin lymphoma Bcl2 , Braf , Ccnd1 , Tp53 Nonseminomatous Germ Cell Tumor Braf nonsyndromic deafness Tgfb3 Noonan syndrome Braf , Kras , Map2k1 , Raf1 Noonan syndrome 1 Braf , Kras , Map2k1 , Raf1 Noonan syndrome 13 Mapk1 Noonan syndrome 3 Kras , Raf1 Noonan syndrome 5 Raf1 Noonan syndrome 7 Braf Noonan syndrome with multiple lentigines Braf , Raf1 Noonan syndrome with multiple lentigines 2 Raf1 Noonan syndrome with multiple lentigines 3 Braf NSAID-Enteropathy Casp9 obesity Akt1 , Akt2 , Bad , Bcl2 , Cycs , Fos , Mapk1 , Mapk3 , Myc , Pik3r1 , Rhoa , Tgfb1 occupational asthma Tgfb1 Occupational Diseases Tgfb1 oculoectodermal syndrome Kras Odontogenic Cysts Smad4 Odontogenic Myxoma Tp53 Oligodontia-Colorectal Cancer Syndrome Axin2 oligomeganephronia Bcl2 opiate dependence Akt1 Optic Nerve Injuries Bax , Bcl2 , Jun , Rhoa Oral Lichen Planus Tp53 oral mucosa leukoplakia Axin2 , Bcl2 , Tp53 oral squamous cell carcinoma Axin1 , Axin2 , Birc5 , Gsk3b , Jun , Tp53 oral submucous fibrosis Tgfb1 , Tp53 orofacial cleft Axin2 Oropharyngeal Neoplasms Tp53 osteoarthritis Bad , Bax , Bcl2 , Casp3 , Casp9 , Pik3r1 , Smad3 , Tgfb1 , Tgfbr1 Osteoarthritis, Experimental Casp3 , Mapk3 Osteoarthritis, Hip Smad3 osteochondrodysplasia Bcl2 , Tgfb1 , Tgfb2 , Tgfbr1 osteogenesis imperfecta Mlh1 , Smad4 osteogenesis imperfecta type 1 Mlh1 osteopetrosis Jun osteoporosis Bax , Bcl2 , Myc , Tgfb1 osteosarcoma Jun , Msh2 , Msh6 , Myc , Tp53 osteosclerosis Ctnnb1 ovarian cancer Akt1 , Apc , Axin2 , Ctnnb1 , Lef1 , Mlh1 , Msh2 , Msh6 , Pik3ca , Pms1 , Pms2 , Smad2 , Smad4 , Tp53 ovarian carcinoma Akt2 , Ccnd1 , Fos , Map2k1 , Msh6 , Raf1 , Rhoa , Smad2 , Tp53 ovarian cyst Msh2 Ovarian Neoplasms Akt1 , Akt2 , Bcl2 , Birc5 , Braf , Ctnnb1 , Gsk3b , Kras , Map2k1 , Mapk1 , Mapk3 , Mlh1 , Msh2 , Msh6 , Myc , Pik3ca , Pik3r1 , Pms2 , Smad7 , Tp53 ovarian small cell carcinoma Tp53 ovary serous adenocarcinoma Kras , Tp53 Oxygen-Induced Retinopathy Bcl2 , Casp3 , Mapk8 Pain Akt1 pancreatic acinar cell adenocarcinoma Braf pancreatic adenocarcinoma Akt3 , Birc5 , Ccnd1 , Map2k1 , Mapk1 , Mapk10 , Mapk8 , Mapk9 , Rac1 , Raf1 , Smad7 pancreatic adenosquamous carcinoma Tgfb2 pancreatic cancer Akt1 , Akt2 , Apc , Bad , Braf , Casp9 , Ccnd1 , Ctnnb1 , Cycs , Kras , Myc , Smad2 , Smad3 , Smad4 , Smad7 , Tcf7l2 , Tgfb1 , Tgfbr2 , Tp53 pancreatic carcinoma Kras , Myc , Raf1 , Smad4 , Tp53 pancreatic ductal adenocarcinoma Ccnd1 , Mapk8 , Pik3r2 , Rac1 , Smad2 , Tgfb1 , Tgfb2 , Tgfb3 , Tgfbr1 pancreatic ductal carcinoma Ccnd1 , Kras , Mapk3 , Pms1 , Smad4 , Tgfb1 , Tgfbr2 , Tp53 pancreatic intraductal papillary-mucinous neoplasm Akt1 , Tp53 Pancreatic Intraepithelial Neoplasia Ccnd1 pancreatic mucinous cystadenoma Kras pancreatic solid pseudopapillary carcinoma Ccnd1 pancreatitis Casp3 , Map2k1 pancytopenia Tp53 papillary renal cell carcinoma Birc5 , Braf papillary thyroid carcinoma Braf , Ccnd1 , Ctnnb1 , Lef1 , Myc , Tp53 papilloma Ccnd1 , Tgfb1 paranasal sinus benign neoplasm Tp53 paraplegia Akt1 Paraproteinemias Braf , Kras , Tp53 Paraquat Lung Smad7 , Tgfb1 Parasitic Liver Diseases Kras , Smad4 , Tp53 parathyroid carcinoma Akt3 , Tgfb2 Parkinson's disease Akt1 , Axin2 , Casp3 , Casp9 , Gsk3b , Mapk1 , Mapk3 Parkinsonism Bad , Casp3 , Casp9 , Mapk8 Partial Agenesis of Corpus Callosum Dcc Pediatric Adrenocortical Carcinoma Tp53 penile benign neoplasm Ccnd1 Penile Neoplasms Kras , Pik3ca , Tp53 periampullary adenoma Apc peripheral nervous system disease Casp9 , Jun peripheral T-cell lymphoma Rhoa peritoneal carcinoma Mlh1 Peritoneal Fibrosis Tgfb1 Peritoneal Neoplasms Ctnnb1 peritonitis Gsk3b Peyronie's disease Tgfb1 PHACE Association Braf Phyllodes Tumor Ctnnb1 , Tp53 Pick's disease Fos Pierson syndrome Rhoa pilocytic astrocytoma Kras pilomatrixoma Ctnnb1 Pitt-Hopkins-like syndrome 2 Msh2 , Msh6 pituitary carcinoma Pms2 Pituitary Stalk Interruption Syndrome Raf1 plasma cell neoplasm Braf , Kras , Tp53 plasmacytoma Bcl2 pleomorphic xanthoastrocytoma Braf , Cycs , Tp53 pleural disease Tgfb1 Pleural Effusion Tp53 Pneumococcal Pneumonia Mapk1 , Mapk3 pneumonia Tgfb1 Poisoning Gsk3b polycystic kidney disease Myc , Pik3ca polycystic kidney disease 1 Myc polycystic liver disease Ctnnb1 polycystic liver disease 1 Ctnnb1 polycystic ovary syndrome Akt2 , Bax , Bcl2 polymicrogyria Akt3 polymyositis Pms1 Polyploidy Tp53 portal hypertension Mapk1 , Pik3r1 post-traumatic stress disorder Bax , Bcl2 , Casp9 , Fos Posterior Leukoencephalopathy Syndrome Tgfb1 Postmenopausal Osteoporosis Tgfb1 Postoperative Cognitive Dysfunction Mapk1 , Mapk3 pre-malignant neoplasm Akt1 , Bax , Casp3 , Casp9 , Ccnd1 , Mapk8 , Mapk9 , Smad3 , Smad4 , Tp53 Premature Aging Bax , Bcl2 , Tp53 Premature Birth Braf priapism Bcl2 primary biliary cholangitis Rhoa , Tgfb1 primary coenzyme Q10 deficiency 7 Ralgds primary cutaneous T-cell non-Hodgkin lymphoma Bax , Braf , Rhoa , Tp53 primary immunodeficiency disease Pik3cd , Pik3r1 primary open angle glaucoma Tp53 primary ovarian insufficiency Myc primary pulmonary hypertension 1 Smad4 Primitive Neuroectodermal Tumors Pms2 prion disease Bax Progressive Diaphyseal Dysplasia 1 Tgfb1 progressive myoclonus epilepsy 9 Apc2 , Tcf3 progressive osseous heteroplasia Ctnnb1 prolactinoma Myc prostate adenocarcinoma Akt1 , Akt2 , Akt3 , Braf , Ctnnb1 , Jun , Map2k1 , Mapk1 , Myc , Pik3ca , Pik3cb , Raf1 , Tp53 prostate cancer Akt1 , Akt2 , Akt3 , Apc , Bax , Bcl2 , Birc5 , Casp3 , Ccnd1 , Ctnnb1 , Kras , Lef1 , Mapk10 , Msh2 , Msh6 , Myc , Pik3ca , Pik3cb , Pik3r1 , Pik3r2 , Pms2 , Rac2 , Raf1 , Smad3 , Tcf3 , Tcf7 , Tcf7l2 , Tgfb1 , Tgfbr2 , Tp53 Prostate Cancer, Hereditary, 1 Braf , Kras , Tp53 prostate carcinoma Akt2 , Bad , Bax , Jun prostate carcinoma in situ Ccnd1 , Kras , Lef1 , Myc , Smad4 prostatic hypertrophy Bad , Myc Prostatic Neoplasms Akt1 , Akt2 , Apc , Bad , Bax , Bcl2 , Birc5 , Braf , Casp3 , Casp9 , Ccnd1 , Ctnnb1 , Gsk3b , Jun , Kras , Map2k1 , Mapk3 , Mapk9 , Mlh1 , Msh3 , Myc , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pms1 , Raf1 , Smad4 , Tgfb1 , Tgfbr2 , Tp53 prostatitis Smad4 proteinuria Rhoa , Tgfb1 Proteus syndrome Akt1 Pseudomonas Infections Mapk8 psoriasis Tgfb1 , Tp53 PTEN hamartoma tumor syndrome Pik3ca pterygium Tp53 Pulmonary Arterial Hypertension Axin2 , Pms2 , Smad4 , Tgfbr1 pulmonary emphysema Jun , Tgfb1 pulmonary fibrosis Bad , Smad4 , Smad7 , Tgfb1 , Tgfbr2 pulmonary hypertension Bcl2 , Birc5 , Mapk1 , Mapk3 , Myc , Rhoa , Smad4 , Smad7 , Tgfb1 , Tgfbr1 , Tgfbr2 , Tp53 pulmonary sarcoidosis Tgfb1 pulmonary tuberculosis Akt1 , Jun pulmonary valve stenosis Braf Pyruvate Dehydrogenase E1-Beta Deficiency Appl1 Radiation Injuries Tgfbr2 Radiation Pneumonitis Tgfb1 Rafiq syndrome Ralgds RASopathy Braf , Kras , Map2k1 , Raf1 rectal benign neoplasm Apc , Fos , Mapk8 , Pik3ca , Pik3cb rectum adenocarcinoma Apc Recurrence Ctnnb1 , Kras Recurrent Infections, with Encephalopathy, Hepatic Dysfunction, and Cardiovascular Malformations Ccnd1 Refractory Anemia Birc5 Refractory Anemia with Excess of Blasts Birc5 renal carcinoma Jun renal cell carcinoma Akt1 , Akt3 , Apc , Bad , Bcl2 , Birc5 , Casp3 , Ccnd1 , Ctnnb1 , Jun , Kras , Map2k1 , Mapk1 , Mlh1 , Msh2 , Myc , Pik3ca , Pik3r1 , Smad2 , Smad4 , Tgfb1 , Tp53 Renal Cell Carcinoma 1 Ctnnb1 , Msh2 renal fibrosis Kras , Mapk1 , Myc Reperfusion Injury Akt1 , Bad , Bax , Bcl2 , Birc5 , Casp3 , Casp9 , Ccnd1 , Dcc , Fos , Jun , Mapk8 , Mapk9 , Pik3r1 , Tgfbr2 , Tp53 Respiratory System Abnormalities Tgfb2 , Tgfb3 Retina Reperfusion Injury Bad , Bax , Bcl2 retinal degeneration Bax , Bcl2 retinal detachment Casp3 , Casp9 retinal disease Casp3 rhabdoid cancer Myc rhabdomyosarcoma Msh2 , Msh6 , Pms2 , Tp53 rheumatic heart disease Bax , Lef1 rheumatoid arthritis Pik3r1 rhinitis Tgfb1 Right Ventricular Hypertrophy Akt1 , Bax , Tgfb1 Roifman-Chitayat Syndrome Pik3cd Romano-Ward Syndrome Braf rosette-forming glioneuronal tumor Pik3ca salivary gland disease Casp3 Salivary Gland Neoplasms Ccnd1 SAPHO syndrome Tp53 sarcoidosis Tgfb1 sarcoma Msh2 , Pik3ca , Tp53 Sarcopenia Bax , Bcl2 schizophrenia Akt1 , Gsk3b , Mapk3 , Mapk8 , Pik3cb , Pik3cd , Tp53 sciatic neuropathy Casp3 , Gsk3b scimitar syndrome Smad2 scrapie Bax , Casp3 , Casp9 sebaceous gland neoplasm Lef1 Sebaceous Nevus Syndrome and Hemimegalencephaly Kras seborrheic keratosis Pik3ca seminoma Kras , Smad4 Sengers syndrome Braf Senior-Loken syndrome Akt3 Senior-Loken Syndrome 7 Akt3 Sepsis Bad , Casp3 , Casp9 , Gsk3b , Mapk1 , Mapk3 , Mapk8 , Rac1 , Tgfb1 Septic Peritonitis Pik3r1 septooptic dysplasia Appl1 serous cystadenocarcinoma Tp53 severe acute respiratory syndrome Casp3 , Casp9 , Mapk1 , Mapk3 , Tgfb1 severe combined immunodeficiency Rac2 Sezary's disease Braf , Mapk1 , Tp53 Shock Mapk1 , Mapk3 SHORT syndrome Pik3r1 short-rib thoracic dysplasia 6 with or without polydactyly Axin2 short-rib thoracic dysplasia 9 with or without polydactyly Axin1 sickle cell anemia Tgfb1 sigmoid colon cancer Apc , Msh2 , Msh6 sigmoid neoplasm Apc , Msh2 , Msh6 silicosis Jun Sjogren's syndrome Tgfb1 skin melanoma Braf , Ctnnb1 , Pik3ca , Tp53 Skin Neoplasms Akt1 , Ctnnb1 , Tgfb1 , Tgfbr1 , Tp53 sleeping sickness Fos small cell carcinoma Birc5 , Tp53 small intestine adenocarcinoma Map2k1 Small-For-Size Syndrome Bad Smith-Kingsmore Syndrome Pik3r1 , Pik3r2 Soft Tissue Neoplasms Bcl2 Sotos syndrome 3 Apc2 spastic ataxia Pik3r5 spermatic cord torsion Casp3 spermatogenic failure 57 Map2k1 Spinal Cord Injuries Akt1 , Bax , Bcl2 , Casp3 , Casp9 , Dcc , Jun , Rhoa , Tgfb1 , Tgfb2 , Tp53 Spinal Cord Reperfusion Injury Bad splenic disease Apc Splenomegaly Apc , Kras split hand-foot malformation Lef1 spondyloarthropathy Tp53 spondylocostal dysostosis 5 Mapk3 Spontaneous Abortions Tgfb1 , Tgfbr1 Spontaneous Neoplasm Regression Tgfb1 sporadic breast cancer Mlh1 Sporadic Papillary Renal Cell Carcinoma Myc squamous cell carcinoma Akt1 , Apc , Bcl2 , Birc5 , Ccnd1 , Kras , Mapk1 , Mapk3 , Mlh1 , Myc , Pik3ca , Tgfb1 , Tp53 Staphylococcal Pneumonia Akt1 status epilepticus Bax , Bcl2 , Casp3 , Ccnd1 , Fos , Gsk3b , Jun steatotic liver disease Akt1 , Cycs , Mapk8 , Myc Stevens-Johnson syndrome Ctnnb1 Stiff-Person syndrome Ctnnb1 stomach cancer Apc , Bax , Bcl2 , Casp3 , Casp9 , Ctnnb1 , Kras , Mlh1 , Msh2 , Msh6 , Pik3ca , Pms2 , Rac1 , Smad4 , Tp53 stomach carcinoma Birc5 , Kras Stomach Neoplasms Apc , Birc5 , Ccnd1 , Jun , Kras , Mapk1 , Mapk3 , Mapk8 , Myc , Pik3ca , Rhoa , Smad4 , Tp53 Streptococcus pneumonia Pik3cd Stroke Akt1 , Casp3 , Ctnnb1 , Mapk8 , Pik3ca , Tgfb1 Sturge-Weber syndrome Map2k1 Subarachnoid Hemorrhage Bcl2 , Casp3 , Casp9 , Gsk3b , Pik3cb substance-induced psychosis Akt1 substance-related disorder Gsk3b Supratentorial Neoplasms Pms2 synovial sarcoma Bcl2 systemic lupus erythematosus Tcf7 systemic scleroderma Tgfbr1 T-cell acute lymphoblastic leukemia Bax , Bcl2 , Kras T-cell non-Hodgkin lymphoma Akt1 , Rhoa , Tp53 Tachycardia Gsk3b tauopathy Gsk3b temporal lobe epilepsy Fos Tendon Injuries Fos teratoma Bax , Ctnnb1 , Kras Testicular Germ Cell Tumor Birc5 Testis Reperfusion Injury Bax , Bcl2 , Casp3 , Casp9 , Mapk1 , Mapk3 tethered spinal cord syndrome Braf thoracic aortic aneurysm Smad2 , Smad3 , Smad4 , Tgfb2 , Tgfb3 , Tgfbr1 , Tgfbr2 thrombocytopenia Cycs , Tgfb1 Thrombocytopenia 4 Cycs thrombosis Pik3cb thymoma Birc5 , Tp53 Thymus Neoplasms Tp53 thyroid cancer Mapk1 , Myc Thyroid Carcinoma, Nonmedullary 1 Kras thyroid gland carcinoma Birc5 Thyroid Neoplasms Akt2 , Braf , Ccnd1 , Ctnnb1 , Kras , Mapk1 , Msh6 , Tp53 thyroiditis Bax Tongue Neoplasms Bcl2 , Fos , Tp53 tongue squamous cell carcinoma Bcl2 , Ccnd1 , Fos , Jun , Tp53 tooth agenesis Axin2 tooth disease Rhoa toxic encephalopathy Casp3 , Fos toxic shock syndrome Pik3cd toxoplasmosis Bax tracheal stenosis Tgfb1 Tracheoesophageal Fistula Apc2 transient cerebral ischemia Axin2 , Bad , Bax , Bcl2 , Casp3 , Casp9 , Cycs transitional cell carcinoma Apc , Bcl2 , Birc5 , Braf , Casp3 , Ccnd1 , Ctnnb1 , Kras , Msh2 , Smad4 , Tp53 Transplant Rejection Bad , Bax , Bcl2 , Casp3 , Myc transthyretin amyloidosis Tp53 traumatic brain injury Bad , Casp3 , Casp9 , Ctnnb1 , Tgfb1 , Tp53 trichorhinophalangeal syndrome type I Myc Trigeminal Nerve Injuries Tp53 trigeminal neuralgia Fos , Mapk1 , Mapk3 , Mapk8 , Mapk9 Triple Negative Breast Neoplasms Kras tuberous sclerosis 1 Ralgds Tubulointerstitial Fibrosis Smad3 , Tgfb1 type 1 diabetes mellitus Casp3 , Casp9 , Tgfb1 type 2 diabetes mellitus Akt1 , Akt2 , Bad , Bax , Bcl2 , Braf , Casp3 , Casp9 , Gsk3b , Mapk1 , Mapk3 , Mapk8 , Mapk9 , Pik3cb , Pik3r1 , Smad4 , Tcf7l2 , Tgfb1 , Tgfbr2 ulcerative colitis Casp3 , Tp53 uremia Tgfb1 , Tgfbr1 ureteral obstruction Akt1 , Casp3 , Casp9 , Mapk1 , Mapk3 , Smad3 , Tgfb1 , Tgfb2 urethral obstruction Mapk1 , Tgfb1 urinary bladder cancer Akt1 , Axin1 , Bax , Bcl2 , Birc5 , Casp3 , Casp9 , Ccnd1 , Ctnnb1 , Gsk3b , Kras , Mlh1 , Msh2 , Msh6 , Myc , Pik3ca , Pms2 , Rhoa , Smad2 , Smad4 , Tgfbr1 , Tp53 Urinary Bladder Neoplasm Kras , Tp53 Urinary Incontinence Mapk1 Urogenital Abnormalities Tgfb2 Urogenital Neoplasms Msh2 , Msh6 , Tp53 Urologic Neoplasms Birc5 , Ccnd1 , Rhoa , Tp53 urticaria Tgfb1 Usher syndrome Tgfb2 Uterine Cervical Neoplasms Birc5 , Ccnd1 , Ctnnb1 , Kras , Mlh1 , Msh2 , Myc , Smad4 uterine corpus cancer Msh2 , Msh6 Uterine Neoplasms Ctnnb1 , Kras , Smad3 uveitis Tgfb1 varicocele Casp9 Vascular Calcification Ctnnb1 vascular dementia Gsk3b , Mapk1 , Smad4 , Tp53 Vascular Malformations Braf , Kras , Map2k1 , Pik3ca , Pik3r1 vasculogenic impotence Tgfbr2 velocardiofacial syndrome Mapk1 Ventilator-Induced Lung Injury Akt1 , Axin2 , Fos Ventricular Dysfunction, Left Ctnnb1 , Pik3ca , Rac1 Ventricular Premature Complexes Tgfb3 Ventricular Remodeling Akt1 , Axin2 , Bax , Bcl2 , Casp3 , Ctnnb1 , Smad2 , Smad3 , Tcf7l2 , Tgfb1 ventricular septal defect Braf Ventricular Tachycardia Raf1 very long chain acyl-CoA dehydrogenase deficiency Tp53 Vici syndrome Smad2 Viral Bronchiolitis Bcl2 Viral Myocarditis Casp3 visceral heterotaxy 4 Mlh1 visceral leishmaniasis Pik3cd vitiligo Pik3r1 , Tgfb1 von Hippel-Lindau disease Ccnd1 vulva cancer Akt1 Vulvar Lichen Sclerosus Tp53 Vulvar Neoplasms Mlh1 , Msh2 , Tp53 Wallerian Degeneration Tgfb1 , Tgfb2 Weight Gain Pik3ca Weight Loss Apc Weissenbacher-Zweymuller syndrome Mapk1 Wernicke encephalopathy Fos withdrawal disorder Fos , Mapk1 , Mapk3 , Rhoa Wolff-Parkinson-White syndrome Tgfbr2 Wounds and Injuries Tgfb1 , Tgfb2 , Tgfb3 X-linked agammaglobulinemia Pik3r1 xeroderma pigmentosum Tp53 xeroderma pigmentosum group D Msh6