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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69051
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Tgfb1
Name: transforming growth factor, beta 1
Acc ID: CHEBI:180664
Term: 4-hydroxy-TEMPO
Definition: A member of the class of aminoxyls that is TEMPO carrying a hydroxy substituent at position 4. It is a radical scavenger which exhibits anti-inflammatory and analgesic properties.
Chemical ID: MESH:C001803
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tgfb1multiple interactionsEXP 6480464CTDtempol inhibits the reaction [Aldosterone results in increased expression of TGFB1 mRNA]; tempol inhibits the reaction [Sodium Chloride results in increased expression of TGFB1 protein]PMID:20232302 PMID:25204689
Tgfb1affects expressionISOTgfb1 (Mus musculus)6480464CTDtempol affects the expression of TGFB1 proteinPMID:24550650
Tgfb1multiple interactionsISOTgfb1 (Mus musculus)6480464CTDtempol inhibits the reaction [Tobacco Smoke Pollution results in decreased expression of TGFB1 mRNA]PMID:32726580
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