TGFB1 (transforming growth factor beta 1) - Rat Genome Database

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Gene: TGFB1 (transforming growth factor beta 1) Homo sapiens
Symbol: TGFB1
Name: transforming growth factor beta 1
RGD ID: 69095
HGNC Page HGNC:11766
Description: Enables several functions, including antigen binding activity; identical protein binding activity; and transforming growth factor beta receptor binding activity. Involved in several processes, including cell surface receptor signaling pathway; positive regulation of macromolecule metabolic process; and positive regulation of signal transduction. Acts upstream of or within epithelial to mesenchymal transition; negative regulation of gene expression; and positive regulation of isotype switching to IgA isotypes. Located in several cellular components, including cell surface; transforming growth factor beta complex; and transforming growth factor beta ligand-receptor complex. Colocalizes with microvillus. Implicated in several diseases, including Behcet's disease; aphthous stomatitis; artery disease (multiple); bone disease (multiple); and lung disease (multiple). Biomarker of several diseases, including artery disease (multiple); autoimmune disease (multiple); carcinoma (multiple); hematologic cancer (multiple); and lung disease (multiple).
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: CED; DPD1; IBDIMDE; LAP; latency-associated peptide; prepro-transforming growth factor beta-1; TGF-beta 1 protein; TGF-beta-1; TGF-beta1; TGFB; TGFbeta; transforming growth factor beta-1; transforming growth factor beta-1 proprotein; transforming growth factor beta1
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh381941,330,323 - 41,353,922 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1941,301,587 - 41,353,922 (-)EnsemblGRCh38hg38GRCh38
GRCh371941,836,228 - 41,859,827 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361946,528,491 - 46,551,656 (-)NCBINCBI36hg18NCBI36
Build 341946,528,658 - 46,551,158NCBI
Celera1938,636,964 - 38,659,992 (-)NCBI
Cytogenetic Map19q13.2NCBI
HuRef1938,268,902 - 38,291,920 (-)NCBIHuRef
CHM1_11941,836,504 - 41,859,495 (-)NCBICHM1_1
T2T-CHM13v2.01944,151,181 - 44,174,790 (-)NCBI
JBrowse: View Region in Genome Browser (JBrowse)