RGD Reference Report - [Expression of transforming growth factor beta 1 in keratinocytes of oral submucous fibrosis tissue]. - Rat Genome Database

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[Expression of transforming growth factor beta 1 in keratinocytes of oral submucous fibrosis tissue].

Authors: Gao, Y  Ling, T  Wu, H 
Citation: Gao Y, etal., Zhonghua Kou Qiang Yi Xue Za Zhi. 1997 Jul;32(4):239-41.
RGD ID: 7394849
Pubmed: PMID:10680515   (View Abstract at PubMed)

To explore significance of transforming growth factor beta 1 (TGF beta 1) in the pathogenesis of oral submucous fibrosis (OSF), TGF beta 1 mRNAs in keratinocytes of the paraffin embeded tissues of 25 OSF cases, 5 normals (NOR) and 10 oral lichen planus (OLP) were determined by the in situ hybridization technique. The result showed that there was an expression of TGF beta 1 mRNA in keratinocytes of 15 OSFs (60%). The positive expression of TGF beta 1 mRNA was mainly in kerationcytes of early and middle stage OSF. There was no expression in that of 5 NORs and 10 OLPs. The study suggests that keratinocytes of OSF tissue may synthesize and release TGF beta 1 which may play an important role in the pathogenesis of OSF and participate as a mediator in the pathogenetic process of OSF.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
oral submucous fibrosis  IEP 7394849 RGD 
oral submucous fibrosis  ISOTGFB1 (Homo sapiens)7394849; 7394849 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Tgfb1  (transforming growth factor, beta 1)

Genes (Mus musculus)
Tgfb1  (transforming growth factor, beta 1)

Genes (Homo sapiens)
TGFB1  (transforming growth factor beta 1)


Additional Information