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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69051
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Tgfb1
Name: transforming growth factor, beta 1
Acc ID: CHEBI:90695
Term: anthra[1,9-cd]pyrazol-6(2H)-one
Definition: A member of the class of anthrapyrazoles that is anthra[1,9-cd]pyrazole substituted at position 6 by an oxo group. An inhibitor of c-Jun N-terminal kinase.
Chemical ID: MESH:C432165
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tgfb1multiple interactionsEXP 6480464CTDpyrazolanthrone inhibits the reaction [Patulin results in increased expression of TGFB1 protein]PMID:34896196
Tgfb1multiple interactionsISOTGFB1 (Homo sapiens)6480464CTDpyrazolanthrone inhibits the reaction [Asbestos, Serpentine results in increased secretion of TGFB1 protein]; pyrazolanthrone inhibits the reaction [EGF promotes the reaction [TGFB1 results in decreased susceptibility to Cisplatin]]; pyrazolanthrone inhibits the reaction [EGF promotes the reaction [TGFB1 results in decreased susceptibility to Gemcitabine]]; pyrazolanthrone inhibits the reaction [IL1B protein results in increased expression of TGFB1 mRNA]; pyrazolanthrone inhibits the reaction [IL1B protein results in increased secretion of TGFB1 protein]PMID:16365456 PMID:21613822 PMID:25358858
Tgfb1multiple interactionsISOTgfb1 (Mus musculus)6480464CTD6,7-dimethyl-2-(2E)-3-(1-methyl-2-phenyl-1H-pyrrolo(2,3-b)pyridin-3-yl-prop-2-enoyl)-1,2,3,4-tetrahydroisoquinoline hydrochloride affects the reaction [pyrazolanthrone affects the reaction [[TGFB1 protein co-treated with TNF protein] affects the expression of PPARGC1A protein]]; pyrazolanthrone affects the reaction [6,7-dimethyl-2-(2E)-3-(1-methyl-2-phenyl-1H-pyrrolo(2,3-b)pyridin-3-yl-prop-2-enoyl)-1,2,3,4-tetrahydroisoquinoline hydrochloride affects the reaction [[TGFB1 protein co-treated with TNF protein] affects the expression of PPARGC1A protein]]; pyrazolanthrone affects the reaction [[TGFB1 protein co-treated with TNF protein] affects the expression of PPARGC1A protein]PMID:31447676
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