PANCREATIC CANCER PATHWAY (PW:0000626)

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Description

Pancreatic cancer is the fourth leading cause of cancer-related deaths. It equally affects both men and women and continues to have a very low overall 5-year survival rate of less than 5%. Pancreatic ductal adenocarcinoma (PDAC) is the predominant form with several precursor lesions such as pancreatic intraepithelial neoplasia (PanIN) graded stage I to III. Other lesions include the intraductal papillary mucinous neoplasm (IPMN) and mucinous cystic neoplasm (MCN). The driver oncogene is believe

Pathway Diagram:

Elsevier Inc. Smarca4 Arid1a Arid1b Pbrm1 Actl6a altered SWI/SNF family mediated chromatin remodeling pathway ---> genome instability altered p53 signaling pathway ---> altered cellular events altered cellular events altered p53 signaling pathway altered p53 signaling pathway ---> altered expression of target genes altered p53 signaling pathway ---> genome instability genome instability Ilk Itga4 altered integrin mediated signaling pathway ---> altered cellular events altered Wnt signaling, canonical pathway ---> altered expression of target genes altered transforming growth factor-beta Smad dependent signaling pathway ---> altered expression of target genes altered integrin mediated signaling pathway altered G1/S transition pathway ---> genome instability altered expression of target genes altered Wnt signaling, canonical pathway altered phosphatidylinositol 3-kinase-Akt signaling pathway ---> altered expression of target genes altered extracellular signal-regulated Raf/Mek/Erk signaling pathway ---> altered expression of target genes altered Hedgehog signaling pathway ---> altered expression of target genes downregulated miRNA ---> upregulated target translation Tp53 Kras Pten Tcf7l2 Smad3 Smad4 Tgfbr2 Lrp2 Gli3 Gli1 Shh Boc Cdkn2a upregulated miRNA ---> downregulated target translation Pancreatic Neoplasms Egfr altered regulation of target genes altered epidermal growth factor/neuregulin signaling pathway ---> altered extracellular signal-regulated Raf/Mek/Erk signaling pathway altered phosphatidylinositol 3-kinase-Akt signaling pathway altered epidermal growth factor/neuregulin signaling pathway Tgfa Egf altered extracellular signal-regulated Raf/Mek/Erk signaling pathway Akt2 altered scatter factor/hepatocyte growth factor signaling pathway altered transforming growth factor-beta Smad dependent signaling pathway Wnt9a upregulated target translation potential pancreatic cancer miRNA altered SWI/SNF family mediated chromatin remodeling pathway altered G1/S transition pathway Itga9 altered scatter factor/hepatocyte growth factor signaling pathway ---> altered phosphatidylinositol 3-kinase-Akt signaling pathway altered scatter factor/hepatocyte growth factor signaling pathway ---> altered extracellular signal-regulated Raf/Mek/Erk signaling pathway altered epidermal growth factor/neuregulin signaling pathway ---> altered phosphatidylinositol 3-kinase-Akt signaling pathway Met altered Hedgehog signaling pathway Itga11 downregulated target translation upregulated miRNA downregulated miRNA altered extracellular signal-regulated Raf/Mek/Erk signaling pathway ---> altered Hedgehog signaling pathway altered extracellular signal-regulated Raf/Mek/Erk signaling pathway ---> altered regulation of target genes altered phosphatidylinositol 3-kinase-Akt signaling pathway ---> altered regulation of target genes potential pancreatic cancer miRNA ---> Pancreatic Neoplasms
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Genes in Pathway:

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pancreatic cancer pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Actl6a actin-like 6A JBrowse link 2 119,112,776 119,128,870 RGD:8694154
G Akt1 AKT serine/threonine kinase 1 JBrowse link 6 137,218,398 137,239,970 RGD:6907045
G Akt2 AKT serine/threonine kinase 2 JBrowse link 1 84,400,939 84,451,223 RGD:5490965
RGD:6907045
G Akt3 AKT serine/threonine kinase 3 JBrowse link 13 95,076,308 95,348,913 RGD:6907045
G Arhgef6 Rac/Cdc42 guanine nucleotide exchange factor 6 JBrowse link X 159,722,031 159,841,344 RGD:6907045
G Arid1a AT-rich interaction domain 1A JBrowse link 5 151,904,687 151,977,973 RGD:8694154
G Arid1b AT-rich interaction domain 1B JBrowse link 1 45,923,119 46,232,301 RGD:8694154
G Bad BCL2-associated agonist of cell death JBrowse link 1 222,198,516 222,207,459 RGD:6907045
G Bcl2l1 Bcl2-like 1 JBrowse link 3 148,259,594 148,314,191 RGD:6907045
G Boc BOC cell adhesion associated, oncogene regulated JBrowse link 11 61,084,216 61,159,220 RGD:5490966
G Braf B-Raf proto-oncogene, serine/threonine kinase JBrowse link 4 67,389,331 67,520,549 RGD:6907045
G Brca2 BRCA2, DNA repair associated JBrowse link 12 503,660 544,754 RGD:6907045
G Casp9 caspase 9 JBrowse link 5 160,356,211 160,373,774 RGD:6907045
G Ccnd1 cyclin D1 JBrowse link 1 218,090,750 218,100,447 RGD:6907045
G Cdc42 cell division cycle 42 JBrowse link 5 155,690,267 155,728,385 RGD:6907045
G Cdk4 cyclin-dependent kinase 4 JBrowse link 7 70,345,971 70,352,689 RGD:6907045
G Cdk6 cyclin-dependent kinase 6 JBrowse link 4 27,781,728 27,969,653 RGD:6907045
G Cdkn2a cyclin-dependent kinase inhibitor 2A JBrowse link 5 107,823,323 107,832,405 RGD:6907045
RGD:5490966
G Chuk conserved helix-loop-helix ubiquitous kinase JBrowse link 1 263,848,829 263,884,354 RGD:6907045
G E2f1 E2F transcription factor 1 JBrowse link 3 150,062,895 150,073,721 RGD:6907045
G E2f3 E2F transcription factor 3 JBrowse link 17 36,334,136 36,408,831 RGD:6907045
G Egf epidermal growth factor JBrowse link 2 68,820,616 68,895,537 RGD:5490965
RGD:6907045
G Egfr epidermal growth factor receptor JBrowse link 14 99,919,485 100,104,136 RGD:5490965
RGD:6907045
G Erbb2 erb-b2 receptor tyrosine kinase 2 JBrowse link 10 86,367,596 86,391,728 RGD:6907045
G Gli1 GLI family zinc finger 1 JBrowse link 7 70,620,794 70,633,171 RGD:5491005
RGD:5490966
G Gli3 GLI family zinc finger 3 JBrowse link 17 52,294,942 52,569,036 RGD:5490966
G Ikbkb inhibitor of nuclear factor kappa B kinase subunit beta JBrowse link 16 74,177,233 74,230,809 RGD:6907045
G Ikbkg inhibitor of nuclear factor kappa B kinase subunit gamma JBrowse link X 156,254,187 156,280,046 RGD:6907045
G Ilk integrin-linked kinase JBrowse link 1 170,578,941 170,585,192 RGD:5490966
G Itga11 integrin subunit alpha 11 JBrowse link 8 67,566,874 67,683,973 RGD:5490966
G Itga4 integrin subunit alpha 4 JBrowse link 3 66,178,745 66,265,547 RGD:5490966
G Itga9 integrin subunit alpha 9 JBrowse link 8 127,271,029 127,576,709 RGD:5490966
G Jak1 Janus kinase 1 JBrowse link 5 119,982,503 120,091,452 RGD:6907045
G Kras KRAS proto-oncogene, GTPase JBrowse link 4 179,482,562 179,515,483 RGD:5490965
RGD:6907045
RGD:5490966
G Lrp2 LDL receptor related protein 2 JBrowse link 3 55,665,153 55,822,484 RGD:5490966
G Map2k1 mitogen activated protein kinase kinase 1 JBrowse link 8 69,134,218 69,722,573 RGD:6907045
G Mapk1 mitogen activated protein kinase 1 JBrowse link 11 88,203,863 88,273,301 RGD:6907045
G Mapk10 mitogen activated protein kinase 10 JBrowse link 14 8,079,955 8,371,508 RGD:6907045
G Mapk3 mitogen activated protein kinase 3 JBrowse link 1 198,192,773 198,198,975 RGD:6907045
G Mapk8 mitogen-activated protein kinase 8 JBrowse link 16 9,620,854 9,709,342 RGD:6907045
G Mapk9 mitogen-activated protein kinase 9 JBrowse link 10 35,333,859 35,374,364 RGD:6907045
G Met MET proto-oncogene, receptor tyrosine kinase JBrowse link 4 44,747,467 44,854,628 RGD:5490965
G Nfkb1 nuclear factor kappa B subunit 1 JBrowse link 2 240,773,520 240,890,053 RGD:6907045
G Pbrm1 polybromo 1 JBrowse link 16 7,103,714 7,202,899 RGD:8694154
G Pgf placental growth factor JBrowse link 6 108,994,016 109,004,598 RGD:6907045
G Pik3ca phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha JBrowse link 2 118,831,350 118,861,456 RGD:6907045
G Pik3cb phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta JBrowse link 8 107,275,849 107,381,088 RGD:6907045
G Pik3cd phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta JBrowse link 5 166,602,053 166,628,028 RGD:6907045
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 JBrowse link 2 31,742,326 31,826,882 RGD:6907045
G Pik3r2 phosphoinositide-3-kinase regulatory subunit 2 JBrowse link 16 20,415,109 20,424,982 RGD:6907045
G Pik3r3 phosphoinositide-3-kinase regulatory subunit 3 JBrowse link 5 135,069,972 135,145,633 RGD:6907045
G Pik3r5 phosphoinositide-3-kinase, regulatory subunit 5 JBrowse link 10 55,013,686 55,078,986 RGD:6907045
G Pld1 phospholipase D1 JBrowse link 2 113,651,967 113,849,403 RGD:6907045
G Pten phosphatase and tensin homolog JBrowse link 1 251,421,814 251,487,634 RGD:5490965
G Rac1 ras-related C3 botulinum toxin substrate 1 JBrowse link 12 13,090,316 13,111,841 RGD:6907045
G Rac2 Rac family small GTPase 2 JBrowse link 7 119,769,708 119,797,111 RGD:6907045
G Rad51 RAD51 recombinase JBrowse link 3 110,918,240 110,942,920 RGD:6907045
G Raf1 Raf-1 proto-oncogene, serine/threonine kinase JBrowse link 4 147,532,040 147,592,769 RGD:6907045
G Rala RAS like proto-oncogene A JBrowse link 17 49,676,073 49,729,133 RGD:6907045
G Ralb RAS like proto-oncogene B JBrowse link 13 35,494,716 35,531,503 RGD:6907045
G Ralbp1 ralA binding protein 1 JBrowse link 9 113,579,107 113,598,477 RGD:6907045
G Ralgds ral guanine nucleotide dissociation stimulator JBrowse link 3 7,090,134 7,130,548 RGD:6907045
G Rb1 RB transcriptional corepressor 1 JBrowse link 15 55,081,582 55,209,060 RGD:6907045
G Rela RELA proto-oncogene, NF-kB subunit JBrowse link 1 220,992,770 221,003,249 RGD:6907045
G Shh sonic hedgehog JBrowse link 4 718,538 727,691 RGD:5490965
G Smad2 SMAD family member 2 JBrowse link 18 72,550,107 72,612,078 RGD:6907045
G Smad3 SMAD family member 3 JBrowse link 8 68,569,530 68,678,349 RGD:5490966
RGD:6907045
G Smad4 SMAD family member 4 JBrowse link 18 69,626,682 69,657,373 RGD:5490966
RGD:6907045
RGD:5490965
G Smarca4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 JBrowse link 8 22,648,323 22,739,468 RGD:8694154
G Stat1 signal transducer and activator of transcription 1 JBrowse link 9 54,287,540 54,327,958 RGD:6907045
G Stat3 signal transducer and activator of transcription 3 JBrowse link 10 88,790,401 88,842,263 RGD:6907045
G Tcf7l2 transcription factor 7 like 2 JBrowse link 1 276,686,911 276,730,517 RGD:5490966
G Tgfa transforming growth factor alpha JBrowse link 4 117,961,877 118,045,923 RGD:5490965
RGD:6907045
G Tgfb1 transforming growth factor, beta 1 JBrowse link 1 82,480,875 82,497,196 RGD:6907045
G Tgfb2 transforming growth factor, beta 2 JBrowse link 13 105,039,639 105,142,010 RGD:6907045
G Tgfb3 transforming growth factor, beta 3 JBrowse link 6 109,913,757 109,936,217 RGD:6907045
G Tgfbr1 transforming growth factor, beta receptor 1 JBrowse link 5 63,056,071 63,119,635 RGD:6907045
G Tgfbr2 transforming growth factor, beta receptor 2 JBrowse link 8 124,310,288 124,399,345 RGD:5490966
RGD:6907045
RGD:5490965
G Tp53 tumor protein p53 JBrowse link 10 56,186,299 56,198,449 RGD:5490966
RGD:6907045
G Vegfa vascular endothelial growth factor A JBrowse link 9 17,340,341 17,355,681 RGD:6907045
G Vegfb vascular endothelial growth factor B JBrowse link 1 222,237,000 222,242,786 RGD:6907045
G Vegfc vascular endothelial growth factor C JBrowse link 16 40,440,371 40,555,178 RGD:6907045
G Vegfd vascular endothelial growth factor D JBrowse link X 31,816,480 31,852,239 RGD:6907045
G Wnt9a Wnt family member 9A JBrowse link 10 45,659,045 45,686,103 RGD:5490966

Pathway Gene Annotations

Disease Annotations Associated with Genes in the pancreatic cancer pathway
Pathway Annotations Associated with Genes in the pancreatic cancer pathway
Pathway TermsGene Symbols
activin signaling pathwaySmad2 , Smad3
acute myeloid leukemia pathwayAkt1 , Akt2 , Akt3 , Bad , Braf , Ccnd1 , Chuk , Ikbkb , Ikbkg , Kras , Map2k1 , Mapk1 , Mapk3 , Nfkb1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Raf1 , Rela , Stat3 , Tcf7l2
adenosine signaling pathwayAkt1 , Bad , Braf , Cdc42 , Chuk , Ikbkb , Mapk1 , Mapk8 , Nfkb1 , Pik3ca
aldosterone signaling pathwayKras , Mapk1 , Mapk3 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5
altered epidermal growth factor/neuregulin signaling pathwayEgf , Egfr , Erbb2 , Tgfa
altered extracellular signal-regulated Raf/Mek/Erk signaling pathwayBraf , Kras , Map2k1 , Raf1
altered G1/S transition pathwayCdkn2a
altered Hedgehog signaling pathwayBoc , Gli1 , Gli3 , Lrp2 , Shh
altered insulin responsive facilitative sugar transporter mediated glucose transport pathwayAkt2
altered integrin mediated signaling pathwayIlk , Itga11 , Itga4 , Itga9
altered p53 signaling pathwayTp53
altered phosphatidylinositol 3-kinase signaling pathwayPik3ca , Pten
altered phosphatidylinositol 3-kinase-Akt signaling pathwayAkt1 , Akt2 , Akt3 , Pik3ca , Pten
altered scatter factor/hepatocyte growth factor signaling pathwayMet
altered SWI/SNF family mediated chromatin remodeling pathwayActl6a , Arid1a , Arid1b , Pbrm1 , Smarca4
altered transforming growth factor-beta Smad dependent signaling pathwaySmad2 , Smad3 , Smad4 , Tgfb1 , Tgfbr1 , Tgfbr2
altered vascular endothelial growth factor signaling pathway involving proteins affecting its expressionVegfa
altered vascular endothelial growth factor signaling pathway involving the main playersVegfa
altered Wnt signaling, canonical pathwayTcf7l2 , Wnt9a
Alzheimer disease pathwayBad , Casp9 , Mapk1 , Mapk3
amyotrophic lateral sclerosis disease pathwayBad , Bcl2l1 , Casp9 , Rac1 , Tp53
apoptotic cell death pathwayAkt1 , Akt2 , Akt3 , Bad , Bcl2l1 , Casp9 , Chuk , Ikbkb , Ikbkg , Nfkb1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Rela , Tp53
Arf family mediated signaling pathwayRac1
arrhythmogenic right ventricular cardiomyopathy pathwayItga11 , Itga4 , Itga9 , Tcf7l2
azathioprine pharmacodynamics pathwayRac1
B cell receptor signaling pathwayAkt1 , Akt2 , Akt3 , Chuk , Ikbkb , Ikbkg , Kras , Map2k1 , Mapk1 , Mapk3 , Nfkb1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Rac1 , Rac2 , Raf1 , Rela
basal cell carcinoma pathwayGli1 , Gli3 , Shh , Tcf7l2 , Tp53 , Wnt9a
bevacizumab pharmacodynamics pathwayVegfa
bladder cancer pathwayBraf , Ccnd1 , Cdk4 , Cdkn2a , E2f1 , E2f3 , Egf , Egfr , Erbb2 , Kras , Map2k1 , Mapk1 , Mapk3 , Pgf , Raf1 , Rb1 , Tp53 , Vegfa , Vegfb , Vegfc , Vegfd
Bone morphogenetic proteins signaling pathwayMapk1 , Smad4
c-Jun N-terminal kinases MAPK signaling pathwayCdc42 , Mapk10 , Mapk8 , Mapk9 , Rac1
calcium/calcium-mediated signaling pathwayEgfr , Erbb2
cell cycle pathway, mitoticCcnd1 , Cdk4 , Cdk6 , Cdkn2a , E2f1 , E2f3 , Rb1 , Smad2 , Smad3 , Smad4 , Tgfb1 , Tgfb2 , Tgfb3 , Tp53
cell-extracellular matrix signaling pathwayItga11 , Itga4 , Itga9
ceramide signaling pathwayAkt1 , Akt2 , Akt3 , Arhgef6 , Bad , Bcl2l1 , Braf , Brca2 , Casp9 , Ccnd1 , Cdc42 , Cdk4 , Cdk6 , Cdkn2a , Chuk , E2f1 , E2f3 , Egf , Egfr , Erbb2 , Ikbkb , Ikbkg , Jak1 , Kras , Map2k1 , Mapk1 , Mapk10 , Mapk3 , Mapk8 , Mapk9 , Nfkb1 , Pgf , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Pld1 , Rac1 , Rac2 , Rad51 , Raf1 , Rala , Ralb , Ralbp1 , Ralgds , Rb1 , Rela , Smad2 , Smad3 , Smad4 , Stat1 , Stat3 , Tgfa , Tgfb1 , Tgfb2 , Tgfb3 , Tgfbr1 , Tgfbr2 , Tp53 , Vegfa , Vegfb , Vegfc , Vegfd
cetuximab pharmacodynamics pathwayEgfr
chemokine mediated signaling pathwayAkt1 , Akt2 , Akt3 , Braf , Cdc42 , Chuk , Ikbkb , Ikbkg , Kras , Map2k1 , Mapk1 , Mapk3 , Nfkb1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Rac1 , Rac2 , Raf1 , Rela , Stat1 , Stat3
chronic myeloid leukemia pathwayAkt1 , Akt2 , Akt3 , Bad , Bcl2l1 , Braf , Ccnd1 , Cdk4 , Cdk6 , Cdkn2a , Chuk , E2f1 , E2f3 , Ikbkb , Ikbkg , Kras , Map2k1 , Mapk1 , Mapk3 , Nfkb1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Raf1 , Rb1 , Rela , Smad3 , Smad4 , Tgfb1 , Tgfb2 , Tgfb3 , Tgfbr1 , Tgfbr2 , Tp53
colorectal cancer pathwayAkt1 , Akt2 , Akt3 , Bad , Braf , Casp9 , Ccnd1 , Kras , Map2k1 , Mapk1 , Mapk10 , Mapk3 , Mapk8 , Mapk9 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Rac1 , Rac2 , Raf1 , Ralgds , Smad2 , Smad3 , Smad4 , Tcf7l2 , Tgfb1 , Tgfb2 , Tgfb3 , Tgfbr1 , Tgfbr2 , Tp53
cortisol signaling pathwaySmarca4
cytokine mediated signaling pathwayEgf , Egfr , Met , Tgfb1 , Tgfb2 , Tgfb3 , Tgfbr1 , Tgfbr2 , Vegfc , Vegfd
dilated cardiomyopathy pathwayItga11 , Itga4 , Itga9 , Tgfb1 , Tgfb2 , Tgfb3
doxorubicin pharmacokinetics pathwayRalbp1
E-cadherin signaling pathwayAkt1 , Akt2 , Ccnd1 , Cdc42 , Egf , Egfr , Pik3ca , Pik3r1 , Rac1
eicosanoid signaling pathwayAkt1 , Egf , Egfr , Pik3r5 , Rac1
eicosanoid signaling pathway via peroxisome proliferator-activated receptor gammaIlk
endocytosis pathwayCdc42 , Egf , Egfr , Met , Pld1 , Smad2 , Smad3 , Tgfb1 , Tgfb2 , Tgfb3 , Tgfbr1 , Tgfbr2
endometrial cancer pathwayAkt1 , Akt2 , Akt3 , Bad , Braf , Casp9 , Ccnd1 , Egf , Egfr , Erbb2 , Ilk , Kras , Map2k1 , Mapk1 , Mapk3 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Pten , Raf1 , Tcf7l2 , Tp53
Endoplasmic Reticulum-associated degradation pathwayMapk10 , Mapk8 , Mapk9
endothelin signaling pathwayAkt1 , Cdc42 , Map2k1 , Mapk1 , Mapk3 , Mapk8 , Rac1 , Raf1
Entamoeba histolyca infection pathwayNfkb1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Rela , Tgfb1 , Tgfb2 , Tgfb3
ephrin - ephrin receptor bidirectional signaling axisCdc42 , Map2k1 , Mapk1 , Mapk3 , Mapk8 , Pik3ca , Pik3r1 , Pik3r5 , Rac1
epidermal growth factor/neuregulin signaling pathwayAkt1 , Akt2 , Akt3 , Bad , Braf , Egf , Egfr , Erbb2 , Kras , Map2k1 , Mapk1 , Mapk10 , Mapk3 , Mapk8 , Mapk9 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Raf1 , Stat1 , Stat3 , Tgfa
erlotinib pharmacodynamics pathwayEgfr
erythropoietin signaling pathwayBcl2l1 , Mapk8 , Nfkb1 , Pik3r1 , Stat1
ether lipid metabolic pathwayPld1
ether lipid metabolic pathwayPld1
FasL mediated signaling pathwayAkt1 , Chuk , Ikbkb , Ikbkg , Mapk10 , Mapk8 , Mapk9 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3
Fc epsilon receptor mediated signaling pathwayAkt1 , Akt2 , Akt3 , Kras , Map2k1 , Mapk1 , Mapk10 , Mapk3 , Mapk8 , Mapk9 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Rac1 , Rac2 , Raf1
Fc gamma receptor mediated signaling pathwayAkt1 , Akt2 , Akt3 , Cdc42 , Map2k1 , Mapk1 , Mapk3 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Pld1 , Rac1 , Rac2 , Raf1
fibroblast growth factor signaling pathwayAkt1 , Mapk1 , Mapk3 , Pik3ca , Pik3r1 , Stat1
forkhead class A signaling pathwayAkt1 , Shh
G1 phase pathwayCcnd1 , Cdk4
G1/S transition pathwayCcnd1 , Cdk4 , Cdk6 , Cdkn2a , Rb1
gefitinib pharmacodynamics pathwayEgfr
glioma pathwayAkt1 , Akt2 , Akt3 , Braf , Ccnd1 , Cdk4 , Cdk6 , Cdkn2a , E2f1 , E2f3 , Egf , Egfr , Kras , Map2k1 , Mapk1 , Mapk3 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Pten , Raf1 , Rb1 , Tgfa , Tp53
glutamate signaling pathwayMapk1 , Mapk3 , Pld1
glycerophospholipid metabolic pathwayPld1
glypican signaling pathwayMapk8 , Mapk9 , Shh , Smad2 , Tgfb1 , Tgfb2 , Tgfb3 , Tgfbr2 , Vegfa
gonadotropin-releasing hormone signaling pathwayCdc42 , Egfr , Kras , Map2k1 , Mapk1 , Mapk10 , Mapk3 , Mapk8 , Mapk9 , Pld1 , Raf1
granulocyte-macrophage colony-stimulating factor signaling pathwayIkbkb , Map2k1 , Mapk1 , Mapk3 , Pik3ca , Pik3r1 , Raf1 , Stat1 , Stat3
Hedgehog signaling pathwayAkt1 , Boc , Gli1 , Gli3 , Lrp2 , Map2k1 , Pik3ca , Pik3r1 , Shh , Tgfb2 , Wnt9a
hepatitis C virus infection pathwayAkt1 , Akt2 , Akt3 , Bad , Braf , Chuk , Egf , Egfr , Ikbkb , Ikbkg , Jak1 , Kras , Mapk1 , Mapk10 , Mapk3 , Mapk8 , Mapk9 , Nfkb1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Raf1 , Rela , Stat1 , Stat3 , Tp53
histone modification pathwayPbrm1 , Smarca4
homologous recombination pathway of double-strand break repairBrca2 , Rad51
Huntington disease pathwayCasp9 , Tp53
hypertrophic cardiomyopathy pathwayItga11 , Itga4 , Itga9 , Tgfb1 , Tgfb2 , Tgfb3
hypoxia inducible factor pathwayAkt1 , Smad3 , Smad4 , Vegfa
inflammatory response pathwayMapk8
influenza A virus infection pathwayAkt1 , Akt2 , Akt3 , Casp9 , Ikbkb , Jak1 , Map2k1 , Mapk1 , Mapk10 , Mapk3 , Mapk8 , Mapk9 , Nfkb1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Raf1 , Rela , Stat1
INO80 family mediated chromatin remodeling pathwayActl6a
inositol metabolic pathwayPik3ca
inositol phosphate metabolic pathwayPik3ca , Pik3cb , Pik3cd , Pten
insulin responsive facilitative sugar transporter mediated glucose transport pathwayAkt1 , Akt2 , Rac1
insulin secretion pathwayCdc42
insulin signaling pathwayAkt1 , Akt2 , Akt3 , Bad , Braf , Ikbkb , Kras , Map2k1 , Mapk1 , Mapk10 , Mapk3 , Mapk8 , Mapk9 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Raf1
insulin-like growth factor signaling pathwayAkt1 , Bad , Pik3ca , Pik3r1 , Raf1
integrin mediated signaling pathwayIlk , Itga11 , Itga4 , Itga9
interleukin-1 signaling pathwayChuk , Ikbkb , Ikbkg , Mapk8 , Nfkb1 , Pik3ca , Pik3r1 , Rela
Interleukin-10 signaling pathwayJak1 , Stat1 , Stat3
interleukin-12 signaling pathwayNfkb1 , Rela , Stat1 , Stat3
interleukin-2 signaling pathwayJak1 , Map2k1 , Mapk1 , Mapk3 , Mapk8 , Mapk9 , Pik3ca , Pik3r1 , Raf1 , Stat1 , Stat3
interleukin-23 signaling pathwayNfkb1 , Pik3ca , Pik3r1 , Rela , Stat1 , Stat3
interleukin-27 signaling pathwayJak1 , Stat1 , Stat3 , Tgfb1
interleukin-3 signaling pathwayBcl2l1 , Pik3ca , Pik3r1
interleukin-4 signaling pathwayAkt1 , Jak1 , Pik3ca , Pik3r1
interleukin-5 signaling pathwayPik3ca , Pik3r1
interleukin-6 signaling pathwayAkt1 , Jak1 , Pik3ca , Pik3r1 , Rac1 , Stat1 , Stat3
intrinsic apoptotic pathwayBad , Bcl2l1 , Casp9
Jak-Stat signaling pathwayAkt1 , Akt2 , Akt3 , Bcl2l1 , Ccnd1 , Jak1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Stat1 , Stat3
Leishmania infection pathwayItga4 , Jak1 , Mapk1 , Mapk3 , Nfkb1 , Rela , Stat1 , Tgfb1 , Tgfb2 , Tgfb3
leptin system pathwayStat3
long term depressionBraf , Kras , Map2k1 , Mapk1 , Mapk3 , Raf1
long term potentiationBraf , Kras , Map2k1 , Mapk1 , Mapk3 , Raf1
measles infection pathwayAkt1 , Akt2 , Akt3 , Ccnd1 , Cdk4 , Cdk6 , Chuk , Jak1 , Nfkb1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Rela , Stat1 , Stat3 , Tp53
melanoma pathwayAkt1 , Akt2 , Akt3 , Bad , Braf , Ccnd1 , Cdk4 , Cdk6 , Cdkn2a , E2f1 , E2f3 , Egf , Egfr , Kras , Map2k1 , Mapk1 , Mapk3 , Met , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Pten , Raf1 , Rb1 , Tp53
mercaptopurine pharmacodynamics pathwayRac1
mercaptopurine pharmacokinetics pathwayRac1
mitogen activated protein kinase signaling pathwayAkt1 , Akt2 , Akt3 , Braf , Cdc42 , Chuk , Egf , Egfr , Erbb2 , Ikbkb , Ikbkg , Kras , Map2k1 , Mapk1 , Mapk10 , Mapk3 , Mapk8 , Mapk9 , Nfkb1 , Rac1 , Rac2 , Raf1 , Rela , Tgfb1 , Tgfb2 , Tgfb3 , Tgfbr1 , Tgfbr2 , Tp53
mTOR signaling pathwayAkt1 , Akt2 , Akt3 , Braf , Ikbkb , Map2k1 , Mapk1 , Mapk3 , Pgf , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Pld1 , Rac1 , Raf1 , Vegfa , Vegfb , Vegfc , Vegfd
Mycobacterium tuberculosis infection pathwayAkt1 , Akt2 , Akt3 , Bad , Casp9 , Jak1 , Mapk1 , Mapk10 , Mapk3 , Mapk8 , Mapk9 , Nfkb1 , Raf1 , Rela , Stat1 , Tgfb1 , Tgfb2 , Tgfb3
myocarditis pathwayCasp9 , Ccnd1 , Rac1 , Rac2
N-cadherin signaling pathwayCdc42 , Mapk8 , Pik3ca , Pik3r1 , Rac1
neurotrophic factor signaling pathwayAkt1 , Akt2 , Akt3 , Bad , Braf , Cdc42 , Ikbkb , Kras , Map2k1 , Mapk1 , Mapk10 , Mapk3 , Mapk8 , Mapk9 , Nfkb1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Rac1 , Raf1 , Rela , Tp53
NOD-like receptor signaling pathwayChuk , Ikbkb , Ikbkg , Mapk1 , Mapk10 , Mapk3 , Mapk8 , Mapk9 , Nfkb1 , Rela
non-small cell lung cancer pathwayAkt1 , Akt2 , Akt3 , Bad , Braf , Casp9 , Ccnd1 , Cdk4 , Cdk6 , Cdkn2a , E2f1 , E2f3 , Egf , Egfr , Erbb2 , Kras , Map2k1 , Mapk1 , Mapk3 , Met , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Pten , Raf1 , Rb1 , Tgfa , Tp53
Non-Stat, Jak dependent pathwayJak1
Notch signaling pathwayCcnd1
nuclear factor kappa B signaling pathwayChuk , Ikbkb , Ikbkg , Nfkb1 , Pik3ca , Pik3r1 , Rela
nuclear factor, erythroid 2 like 2 signaling pathwayIkbkb , Pten
p38 MAPK signaling pathwayCdc42 , Rac1
p53 signaling pathwayAkt1 , Casp9 , Ccnd1 , Cdk4 , Cdk6 , Cdkn2a , Mapk8 , Mapk9 , Pten , Tp53
p53-dependent G1/S DNA damage checkpoint pathwayTp53
pancreatic cancer pathwayActl6a , Akt1 , Akt2 , Akt3 , Arhgef6 , Arid1a , Arid1b , Bad , Bcl2l1 , Boc , Braf , Brca2 , Casp9 , Ccnd1 , Cdc42 , Cdk4 , Cdk6 , Cdkn2a , Chuk , E2f1 , E2f3 , Egf , Egfr , Erbb2 , Gli1 , Gli3 , Ikbkb , Ikbkg , Ilk , Itga11 , Itga4 , Itga9 , Jak1 , Kras , Lrp2 , Map2k1 , Mapk1 , Mapk10 , Mapk3 , Mapk8 , Mapk9 , Met , Nfkb1 , Pbrm1 , Pgf , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Pld1 , Pten , Rac1 , Rac2 , Rad51 , Raf1 , Rala , Ralb , Ralbp1 , Ralgds , Rb1 , Rela , Shh , Smad2 , Smad3 , Smad4 , Smarca4 , Stat1 , Stat3 , Tcf7l2 , Tgfa , Tgfb1 , Tgfb2 , Tgfb3 , Tgfbr1 , Tgfbr2 , Tp53 , Vegfa , Vegfb , Vegfc , Vegfd , Wnt9a
panitumumab pharmacodynamics pathwayEgfr
Parkinson disease pathwayCasp9
phagocytosis pathwayRac1
phosphatidylinositol 3-kinase class I signaling pathwayPik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Pten , Rac1
phosphatidylinositol 3-kinase signaling pathwayPik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Pten
phosphatidylinositol 3-kinase-Akt signaling pathwayAkt1 , Akt2 , Akt3 , Bad , Casp9 , Chuk , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pten , Raf1
phosphoinositide metabolic pathwayEgfr , Erbb2 , Pik3ca , Pik3cd , Pik3r1 , Pten
Plasmodium infection pathwayMet , Tgfb1 , Tgfb2 , Tgfb3
platelet-derived growth factor signaling pathwayBraf , Jak1 , Map2k1 , Mapk1 , Mapk10 , Mapk3 , Mapk8 , Mapk9 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Pten , Rac1 , Raf1 , Stat1 , Stat3
primary immunodeficiency disease pathwayIkbkg
prion diseases pathwayMap2k1 , Mapk1 , Mapk3
prostate cancer pathwayAkt1 , Akt2 , Akt3 , Bad , Braf , Casp9 , Ccnd1 , Chuk , E2f1 , E2f3 , Egf , Egfr , Erbb2 , Ikbkb , Ikbkg , Kras , Map2k1 , Mapk1 , Mapk3 , Nfkb1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Pten , Raf1 , Rb1 , Rela , Tcf7l2 , Tgfa , Tp53
Ras mediated signaling pathwayErbb2
Reelin signaling pathwayAkt1 , Mapk8 , Pik3ca , Pik3r1
renal cell cancer pathwayAkt1 , Akt2 , Akt3 , Braf , Cdc42 , Kras , Map2k1 , Mapk1 , Mapk3 , Met , Pbrm1 , Pgf , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Rac1 , Raf1 , Tgfa , Tgfb1 , Tgfb2 , Tgfb3 , Vegfa , Vegfb , Vegfc , Vegfd
Retinoic acid-inducible gene (RIG) I-like receptor signaling pathwayChuk , Ikbkb , Ikbkg , Mapk10 , Mapk8 , Mapk9 , Nfkb1 , Rela
rheumatoid arthritis disease pathwayPgf , Tgfb1 , Tgfb2 , Tgfb3 , Vegfa , Vegfb
Rho/Rac/Cdc42 mediated signaling pathwayCdc42 , Mapk8 , Rac1
RNA polymerase III transcription pathwayRb1
S phase pathwayCcnd1 , Cdk4
scatter factor/hepatocyte growth factor signaling pathwayMet , Pik3r1
small cell lung cancer pathwayAkt1 , Akt2 , Akt3 , Bcl2l1 , Casp9 , Ccnd1 , Cdk4 , Cdk6 , Chuk , E2f1 , E2f3 , Ikbkb , Ikbkg , Nfkb1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Pten , Rb1 , Rela , Tp53
sphingosine 1-phosphate signaling pathwayAkt1 , Akt3 , Cdc42 , Mapk1 , Mapk3 , Mapk8 , Rac1 , Vegfa
SWI/SNF family mediated chromatin remodeling pathwayActl6a , Arid1a , Arid1b , Pbrm1 , Smarca4
syndecan signaling pathwayEgfr , Mapk1 , Mapk3 , Mapk8 , Rac1 , Tgfb1
T cell receptor signaling pathwayAkt1 , Akt2 , Akt3 , Cdc42 , Cdk4 , Chuk , Ikbkb , Ikbkg , Kras , Map2k1 , Mapk1 , Mapk3 , Mapk9 , Nfkb1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Raf1 , Rela
the extracellular signal-regulated Raf/Mek/Erk signaling pathwayBraf , Kras , Map2k1 , Mapk1 , Mapk3 , Raf1
thyroid cancer pathwayBraf , Ccnd1 , Kras , Map2k1 , Mapk1 , Mapk3 , Tcf7l2 , Tp53
tioguanine pharmacodynamics pathwayRac1
titanium dioxide nanoparticle response pathwayTp53
Toll-like receptor signaling pathwayAkt1 , Akt2 , Akt3 , Chuk , Ikbkb , Ikbkg , Map2k1 , Mapk1 , Mapk10 , Mapk3 , Mapk8 , Mapk9 , Nfkb1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Rac1 , Rela , Stat1
Toxoplasma gondii infection pathwayAkt1 , Akt2 , Akt3 , Bad , Bcl2l1 , Casp9 , Chuk , Ikbkb , Ikbkg , Jak1 , Mapk1 , Mapk10 , Mapk3 , Mapk8 , Mapk9 , Nfkb1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Rela , Stat1 , Stat3 , Tgfb1 , Tgfb2 , Tgfb3
Trail mediated signaling pathwayChuk , Ikbkb , Ikbkg , Mapk1 , Mapk3 , Mapk8 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3
transforming growth factor-beta Smad dependent signaling pathwaySmad2 , Smad3 , Smad4 , Tgfb1 , Tgfb2 , Tgfb3 , Tgfbr1 , Tgfbr2
transforming growth factor-beta superfamily mediated signaling pathwayMapk1 , Mapk3 , Smad2 , Smad3 , Smad4 , Tgfb1 , Tgfb2 , Tgfb3 , Tgfbr1 , Tgfbr2
trastuzumab pharmacodynamics pathwayEgfr
Trypanosoma cruzi infection pathwayAkt1 , Akt2 , Akt3 , Chuk , Ikbkb , Ikbkg , Mapk1 , Mapk10 , Mapk3 , Mapk8 , Mapk9 , Nfkb1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Rela , Smad2 , Smad3 , Tgfb1 , Tgfb2 , Tgfb3 , Tgfbr1 , Tgfbr2
tumor necrosis factor mediated signaling pathwayChuk , Ikbkb , Ikbkg , Nfkb1 , Rela , Stat1
type 2 diabetes mellitus pathwayAkt2 , Ikbkb , Mapk1 , Mapk10 , Mapk3 , Mapk8 , Mapk9 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5
type II interferon signaling pathwayAkt1 , Jak1 , Map2k1 , Mapk1 , Mapk3 , Pik3ca , Pik3r1 , Stat1 , Stat3
vascular endothelial growth factor signaling pathwayAkt1 , Akt2 , Akt3 , Bad , Braf , Casp9 , Cdc42 , Kras , Map2k1 , Mapk1 , Mapk3 , Pgf , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Rac1 , Rac2 , Raf1 , Vegfa , Vegfb , Vegfc , Vegfd
vinblastine pharmacodynamics pathwayRalbp1 , Tp53
vincristine pharmacodynamics pathwayRalbp1 , Tp53
vindesine pharmacodynamics pathwayRalbp1 , Tp53
vinorelbine pharmacodynamics pathwayRalbp1 , Tp53
Wnt signaling pathwayCcnd1 , Mapk10 , Mapk8 , Mapk9 , Rac1 , Rac2 , Smad2 , Smad3 , Smad4 , Tcf7l2 , Tp53 , Wnt9a
Wnt signaling, canonical pathwaySmarca4 , Tcf7l2 , Wnt9a
Wnt signaling, non-canonical pathwayCdc42 , Mapk10 , Mapk8 , Mapk9 , Rac1
Wnt signaling, the planar cell polarity pathwayRac1
Phenotype Annotations Associated with Genes in the pancreatic cancer pathway

References Associated with the pancreatic cancer pathway:

Ontology Path Diagram:

paths to the root

Import into Pathway Studio: