PANCREATIC CANCER PATHWAY (PW:0000626)

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Description

Pancreatic cancer is the fourth leading cause of cancer-related deaths. It equally affects both men and women and continues to have a very low overall 5-year survival rate of less than 5%. Pancreatic ductal adenocarcinoma (PDAC) is the predominant form with several precursor lesions such as pancreatic intraepithelial neoplasia (PanIN) graded stage I to III. Other lesions include the intraductal papillary mucinous neoplasm (IPMN) and mucinous cystic neoplasm (MCN). The driver oncogene is believe

Pathway Diagram:

Elsevier Inc. Smarca4 Arid1a Arid1b Pbrm1 Actl6a altered SWI/SNF family mediated chromatin remodeling pathway ---> genome instability altered p53 signaling pathway ---> altered cellular events altered cellular events altered p53 signaling pathway altered p53 signaling pathway ---> altered expression of target genes altered p53 signaling pathway ---> genome instability genome instability Ilk Itga4 altered integrin mediated signaling pathway ---> altered cellular events altered Wnt signaling, canonical pathway ---> altered expression of target genes altered transforming growth factor-beta Smad dependent signaling pathway ---> altered expression of target genes altered integrin mediated signaling pathway altered G1/S transition pathway ---> genome instability altered expression of target genes altered Wnt signaling, canonical pathway altered phosphatidylinositol 3-kinase-Akt signaling pathway ---> altered expression of target genes altered extracellular signal-regulated Raf/Mek/Erk signaling pathway ---> altered expression of target genes altered Hedgehog signaling pathway ---> altered expression of target genes downregulated miRNA ---> upregulated target translation Tp53 Kras Pten Tcf7l2 Smad3 Smad4 Tgfbr2 Lrp2 Gli3 Gli1 Shh Boc Cdkn2a upregulated miRNA ---> downregulated target translation Pancreatic Neoplasms Egfr altered regulation of target genes altered epidermal growth factor/neuregulin signaling pathway ---> altered extracellular signal-regulated Raf/Mek/Erk signaling pathway altered phosphatidylinositol 3-kinase-Akt signaling pathway altered epidermal growth factor/neuregulin signaling pathway Tgfa Egf altered extracellular signal-regulated Raf/Mek/Erk signaling pathway Akt2 altered scatter factor/hepatocyte growth factor signaling pathway altered transforming growth factor-beta Smad dependent signaling pathway Wnt9a upregulated target translation potential pancreatic cancer miRNA altered SWI/SNF family mediated chromatin remodeling pathway altered G1/S transition pathway Itga9 altered scatter factor/hepatocyte growth factor signaling pathway ---> altered phosphatidylinositol 3-kinase-Akt signaling pathway altered scatter factor/hepatocyte growth factor signaling pathway ---> altered extracellular signal-regulated Raf/Mek/Erk signaling pathway altered epidermal growth factor/neuregulin signaling pathway ---> altered phosphatidylinositol 3-kinase-Akt signaling pathway Met altered Hedgehog signaling pathway Itga11 downregulated target translation upregulated miRNA downregulated miRNA altered extracellular signal-regulated Raf/Mek/Erk signaling pathway ---> altered Hedgehog signaling pathway altered extracellular signal-regulated Raf/Mek/Erk signaling pathway ---> altered regulation of target genes altered phosphatidylinositol 3-kinase-Akt signaling pathway ---> altered regulation of target genes potential pancreatic cancer miRNA ---> Pancreatic Neoplasms
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Genes in Pathway:

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pancreatic cancer pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Actl6a actin-like 6A JBrowse link 2 119,112,776 119,128,870 RGD:8694154
G Akt1 AKT serine/threonine kinase 1 JBrowse link 6 137,218,398 137,239,970 RGD:6907045
G Akt2 AKT serine/threonine kinase 2 JBrowse link 1 84,400,939 84,451,223 RGD:5490965
RGD:6907045
G Akt3 AKT serine/threonine kinase 3 JBrowse link 13 95,076,308 95,348,913 RGD:6907045
G Arhgef6 Rac/Cdc42 guanine nucleotide exchange factor 6 JBrowse link X 159,722,031 159,841,344 RGD:6907045
G Arid1a AT-rich interaction domain 1A JBrowse link 5 151,904,687 151,977,973 RGD:8694154
G Arid1b AT-rich interaction domain 1B JBrowse link 1 45,923,119 46,232,301 RGD:8694154
G Bad BCL2-associated agonist of cell death JBrowse link 1 222,198,516 222,207,459 RGD:6907045
G Bcl2l1 Bcl2-like 1 JBrowse link 3 148,259,594 148,314,191 RGD:6907045
G Boc BOC cell adhesion associated, oncogene regulated JBrowse link 11 61,084,216 61,159,220 RGD:5490966
G Braf B-Raf proto-oncogene, serine/threonine kinase JBrowse link 4 67,389,331 67,520,549 RGD:6907045
G Brca2 BRCA2, DNA repair associated JBrowse link 12 503,660 544,754 RGD:6907045
G Casp9 caspase 9 JBrowse link 5 160,356,211 160,373,774 RGD:6907045
G Ccnd1 cyclin D1 JBrowse link 1 218,090,750 218,100,447 RGD:6907045
G Cdc42 cell division cycle 42 JBrowse link 5 155,690,267 155,728,385 RGD:6907045
G Cdk4 cyclin-dependent kinase 4 JBrowse link 7 70,345,971 70,352,689 RGD:6907045
G Cdk6 cyclin-dependent kinase 6 JBrowse link 4 27,781,728 27,969,653 RGD:6907045
G Cdkn2a cyclin-dependent kinase inhibitor 2A JBrowse link 5 107,823,323 107,832,405 RGD:6907045
RGD:5490966
G Chuk conserved helix-loop-helix ubiquitous kinase JBrowse link 1 263,848,829 263,884,354 RGD:6907045
G E2f1 E2F transcription factor 1 JBrowse link 3 150,062,895 150,073,721 RGD:6907045
G E2f3 E2F transcription factor 3 JBrowse link 17 36,334,136 36,408,831 RGD:6907045
G Egf epidermal growth factor JBrowse link 2 68,820,616 68,895,537 RGD:5490965
RGD:6907045
G Egfr epidermal growth factor receptor JBrowse link 14 99,919,485 100,104,136 RGD:5490965
RGD:6907045
G Erbb2 erb-b2 receptor tyrosine kinase 2 JBrowse link 10 86,367,596 86,391,728 RGD:6907045
G Gli1 GLI family zinc finger 1 JBrowse link 7 70,620,794 70,633,171 RGD:5491005
RGD:5490966
G Gli3 GLI family zinc finger 3 JBrowse link 17 52,294,942 52,569,036 RGD:5490966
G Ikbkb inhibitor of nuclear factor kappa B kinase subunit beta JBrowse link 16 74,177,233 74,230,809 RGD:6907045
G Ikbkg inhibitor of nuclear factor kappa B kinase subunit gamma JBrowse link X 156,254,187 156,280,046 RGD:6907045
G Ilk integrin-linked kinase JBrowse link 1 170,578,941 170,585,192 RGD:5490966
G Itga11 integrin subunit alpha 11 JBrowse link 8 67,566,874 67,683,973 RGD:5490966
G Itga4 integrin subunit alpha 4 JBrowse link 3 66,178,745 66,265,547 RGD:5490966
G Itga9 integrin subunit alpha 9 JBrowse link 8 127,271,029 127,576,709 RGD:5490966
G Jak1 Janus kinase 1 JBrowse link 5 119,982,503 120,091,452 RGD:6907045
G Kras KRAS proto-oncogene, GTPase JBrowse link 4 179,482,562 179,515,483 RGD:5490965
RGD:6907045
RGD:5490966
G Lrp2 LDL receptor related protein 2 JBrowse link 3 55,665,153 55,822,484 RGD:5490966
G Map2k1 mitogen activated protein kinase kinase 1 JBrowse link 8 69,134,218 69,722,573 RGD:6907045
G Mapk1 mitogen activated protein kinase 1 JBrowse link 11 88,203,863 88,273,301 RGD:6907045
G Mapk10 mitogen activated protein kinase 10 JBrowse link 14 8,079,955 8,371,508 RGD:6907045
G Mapk3 mitogen activated protein kinase 3 JBrowse link 1 198,192,773 198,198,975 RGD:6907045
G Mapk8 mitogen-activated protein kinase 8 JBrowse link 16 9,620,854 9,709,342 RGD:6907045
G Mapk9 mitogen-activated protein kinase 9 JBrowse link 10 35,333,859 35,374,364 RGD:6907045
G Met MET proto-oncogene, receptor tyrosine kinase JBrowse link 4 44,747,467 44,854,628 RGD:5490965
G Nfkb1 nuclear factor kappa B subunit 1 JBrowse link 2 240,773,520 240,890,053 RGD:6907045
G Pbrm1 polybromo 1 JBrowse link 16 7,103,714 7,202,899 RGD:8694154
G Pgf placental growth factor JBrowse link 6 108,994,016 109,004,598 RGD:6907045
G Pik3ca phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha JBrowse link 2 118,831,350 118,861,456 RGD:6907045
G Pik3cb phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta JBrowse link 8 107,275,849 107,381,088 RGD:6907045
G Pik3cd phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta JBrowse link 5 166,602,053 166,628,028 RGD:6907045
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 JBrowse link 2 31,742,326 31,826,882 RGD:6907045
G Pik3r2 phosphoinositide-3-kinase regulatory subunit 2 JBrowse link 16 20,415,109 20,424,982 RGD:6907045
G Pik3r3 phosphoinositide-3-kinase regulatory subunit 3 JBrowse link 5 135,069,972 135,145,633 RGD:6907045
G Pik3r5 phosphoinositide-3-kinase, regulatory subunit 5 JBrowse link 10 55,013,686 55,078,986 RGD:6907045
G Pld1 phospholipase D1 JBrowse link 2 113,651,967 113,849,403 RGD:6907045
G Pten phosphatase and tensin homolog JBrowse link 1 251,421,814 251,487,634 RGD:5490965
G Rac1 Rac family small GTPase 1 JBrowse link 12 13,090,316 13,111,841 RGD:6907045
G Rac2 Rac family small GTPase 2 JBrowse link 7 119,769,708 119,797,111 RGD:6907045
G Rad51 RAD51 recombinase JBrowse link 3 110,918,240 110,942,920 RGD:6907045
G Raf1 Raf-1 proto-oncogene, serine/threonine kinase JBrowse link 4 147,532,040 147,592,769 RGD:6907045
G Rala RAS like proto-oncogene A JBrowse link 17 49,676,073 49,729,133 RGD:6907045
G Ralb RAS like proto-oncogene B JBrowse link 13 35,494,716 35,531,503 RGD:6907045
G Ralbp1 ralA binding protein 1 JBrowse link 9 113,579,107 113,598,477 RGD:6907045
G Ralgds ral guanine nucleotide dissociation stimulator JBrowse link 3 7,090,134 7,130,548 RGD:6907045
G Rb1 RB transcriptional corepressor 1 JBrowse link 15 55,081,582 55,209,060 RGD:6907045
G Rela RELA proto-oncogene, NF-kB subunit JBrowse link 1 220,992,770 221,003,249 RGD:6907045
G Shh sonic hedgehog JBrowse link 4 718,538 727,691 RGD:5490965
G Smad2 SMAD family member 2 JBrowse link 18 72,550,107 72,612,078 RGD:6907045
G Smad3 SMAD family member 3 JBrowse link 8 68,569,530 68,678,349 RGD:5490966
RGD:6907045
G Smad4 SMAD family member 4 JBrowse link 18 69,626,682 69,657,373 RGD:5490966
RGD:6907045
RGD:5490965
G Smarca4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 JBrowse link 8 22,648,323 22,739,468 RGD:8694154
G Stat1 signal transducer and activator of transcription 1 JBrowse link 9 54,287,540 54,327,958 RGD:6907045
G Stat3 signal transducer and activator of transcription 3 JBrowse link 10 88,790,401 88,842,263 RGD:6907045
G Tcf7l2 transcription factor 7 like 2 JBrowse link 1 276,686,911 276,730,517 RGD:5490966
G Tgfa transforming growth factor alpha JBrowse link 4 117,961,877 118,045,923 RGD:5490965
RGD:6907045
G Tgfb1 transforming growth factor, beta 1 JBrowse link 1 82,480,875 82,497,196 RGD:6907045
G Tgfb2 transforming growth factor, beta 2 JBrowse link 13 105,039,639 105,142,010 RGD:6907045
G Tgfb3 transforming growth factor, beta 3 JBrowse link 6 109,913,757 109,936,217 RGD:6907045
G Tgfbr1 transforming growth factor, beta receptor 1 JBrowse link 5 63,056,071 63,119,635 RGD:6907045
G Tgfbr2 transforming growth factor, beta receptor 2 JBrowse link 8 124,310,288 124,399,345 RGD:5490966
RGD:6907045
RGD:5490965
G Tp53 tumor protein p53 JBrowse link 10 56,186,299 56,198,449 RGD:5490966
RGD:6907045
G Vegfa vascular endothelial growth factor A JBrowse link 9 17,340,341 17,355,681 RGD:6907045
G Vegfb vascular endothelial growth factor B JBrowse link 1 222,237,000 222,242,786 RGD:6907045
G Vegfc vascular endothelial growth factor C JBrowse link 16 40,440,371 40,555,178 RGD:6907045
G Vegfd vascular endothelial growth factor D JBrowse link X 31,816,480 31,852,239 RGD:6907045
G Wnt9a Wnt family member 9A JBrowse link 10 45,659,045 45,686,103 RGD:5490966

Pathway Gene Annotations

Disease Annotations Associated with Genes in the pancreatic cancer pathway
Disease TermsGene Symbols
abdominal aortic aneurysmMapk8
Aberrant Crypt FociMapk1 , Mapk3 , Tgfb2
Abortion, SpontaneousPgf , Tgfb1 , Tgfbr1
Absence of Tibia with PolydactylyShh
acoustic neuromaVegfa
Acro-OsteolysisSmad4
Acrocallosal Syndrome, Schinzel TypeShh
Acromicric DysplasiaSmad2 , Tgfb1
actinic keratosisTgfb1
acute chest syndromeVegfa
acute kidney failureBad , Bcl2l1 , Egf , Egfr , Lrp2 , Met , Nfkb1 , Rb1 , Tgfa , Tgfb1 , Tp53 , Vegfa
Acute Liver FailureMapk8 , Met
Acute Lung InjuryEgfr , Tgfb1 , Vegfa
Acute Lymphoblastic Leukemia, with Lymphomatous FeaturesJak1
acute lymphocytic leukemiaPten
acute myeloid leukemiaBcl2l1 , Ccnd1 , Cdk6 , Cdkn2a , Jak1 , Kras , Met , Stat3 , Tp53 , Vegfa
acute promyelocytic leukemiaAkt1 , Gli1
Acyl-CoA Dehydrogenase Family, Member 9, Deficiency ofPik3ca
adenocarcinomaArid1a , Ccnd1 , Cdkn2a , Egf , Egfr , Erbb2 , Kras , Met , Nfkb1 , Pik3ca , Pten , Stat3 , Tcf7l2 , Tgfb1 , Tp53 , Vegfa
adenoid cystic carcinomaArid1a , Ccnd1 , Kras , Pik3ca , Pten , Stat3 , Tp53
adenomaBcl2l1 , Kras , Tp53
adrenal carcinomaBraf , Pik3ca , Tp53
Adrenal Gland NeoplasmsCdc42 , Cdkn2a , Rb1 , Tp53
adrenocortical carcinomaBraf , Cdkn2a , Egfr , Pik3ca , Rb1 , Tp53
adult T-cell leukemiaStat3 , Tp53
adult-onset Still's diseaseVegfa
agammaglobulinemiaPik3r1
Agammaglobulinemia 7, Autosomal RecessivePik3r1
AIDS-Associated NephropathyEgf
AlbuminuriaLrp2
alcoholic liver cirrhosisRela , Smad3 , Tgfb1
allergic conjunctivitisTgfb1
allergic contact dermatitisVegfa
allergic hypersensitivity diseaseTgfb1
Alzheimer's diseaseAkt1 , Bad , Bcl2l1 , Cdc42 , E2f1 , Egf , Egfr , Ikbkb , Mapk10 , Mapk8 , Mapk9 , Pik3r1 , Stat3 , Tp53 , Vegfa
ameloblastomaBraf
amphetamine abuseAkt1 , Rela
amyotrophic lateral sclerosisAkt1 , Bad , Bcl2l1 , Casp9 , Pgf , Tp53 , Vegfa
amyotrophic lateral sclerosis type 1Bcl2l1 , Vegfa
anaplastic large cell lymphomaStat3
Anaplastic Thyroid CarcinomaTp53
anemiaCdk6 , Kras
AnetodermaTgfb1
AneurysmSmad3 , Tgfbr2
angiomyolipomaPten , Stat1 , Stat3
angiosarcomaCcnd1 , Kras , Stat3 , Tp53 , Vegfa , Vegfc
Anhidrotic Ectodermal Dysplasia with Immunodeficiency, Osteopetrosis, and LymphedemaIkbkg
Animal Disease ModelsAkt1 , Erbb2 , Kras , Mapk1 , Mapk3 , Mapk8 , Mapk9 , Stat3 , Tp53
anisometropiaPten
ankylosing spondylitisPgf
anodontiaGli3
Anorectal MalformationsGli3 , Shh
anti-basement membrane glomerulonephritisItga4 , Mapk8
aortic aneurysmSmad3 , Tgfb2 , Tgfbr1 , Tgfbr2
aortic diseaseSmad4
aortic valve diseaseEgfr
aortic valve insufficiencyTgfb1 , Tgfb2
aortic valve stenosisEgfr
Aortic Valve, Calcification ofAkt1
Aplasia Cutis Congenita with Epibulbar DermoidsKras
aplastic anemiaTgfb1
ARC syndromeBrca2
arrhythmogenic right ventricular cardiomyopathyTgfb3
arrhythmogenic right ventricular dysplasia 1Tgfb3
Arsenic PoisoningTp53
ARTERIAL DISSECTIONSmad3
arteriosclerosisMapk9 , Met , Rela , Tgfb1 , Tgfbr2
Arteriovenous FistulaVegfa
arteriovenous malformations of the brainEgfr , Kras , Vegfa
Arthrogryposis Multiplex Congenita, Distal Type 1Met
asthmaChuk , Egfr , Pgf , Pten , Tgfb1 , Vegfa
Asthma, OccupationalTgfb1
astrocytomaAkt1 , Akt2 , Akt3 , Arid1a , Arid1b , Braf , Ccnd1 , Kras , Met , Tp53
AtaxiaPten
ataxia with oculomotor apraxia type 3Pik3r5
atherosclerosisAkt1 , Pgf , Stat3 , Vegfa , Vegfc
atopic dermatitisMapk8 , Tgfb1
atrial fibrillationVegfa
atrioventricular septal defectShh
AtrophyMapk3 , Stat3
attention deficit hyperactivity disorderVegfa
Atypical Mycobacteriosis, Familial, X-Linked 1Ikbkg
autism spectrum disorderArid1b , Itga4 , Mapk3 , Shh
autistic disorderEgf , Itga4 , Mapk1 , Met , Pten , Stat3
Autoimmune Disease, Multisystem, Infantile-Onset, 1Stat3
Autoimmune DiseasesStat3 , Tgfb2
autoimmune hepatitisTgfb1
autoimmune lymphoproliferative syndrome type 4Kras
autoimmune thrombocytopenic purpuraTgfb1
autoimmune thyroiditisLrp2
Autosomal Dominant Mental Retardation 12Arid1b
autosomal dominant mental retardation 48Rac1
autosomal dominant polycystic kidney diseaseLrp2
Autosomal Recessive Dyskeratosis CongenitaTp53
autosomal recessive limb-girdle muscular dystrophy type 2LBrca2
autosomal recessive nonsyndromic deafness 97Met
autosomal recessive polycystic kidney diseaseAkt1 , Egfr , Pik3ca
bacterial infectious diseaseCasp9
bacterial pneumoniaChuk , Pgf , Stat3
Balkan nephropathyTp53
Bannayan-Riley-Ruvalcaba syndromePik3ca , Pten
Bardet-Biedl syndromeAkt3 , Gli1
Barrett's esophagusRela
basal cell carcinomaErbb2 , Pik3ca , Rb1 , Shh , Tp53
Behcet's diseaseIkbkg , Stat3 , Tgfb1 , Vegfa
berylliosisTgfb1
Bile Duct NeoplasmsEgfr , Met
biliary atresiaPten , Shh
bipolar disorderAkt1 , Cdc42
bladder urothelial carcinomaAkt1 , Braf , Cdkn2a , Erbb2 , Kras , Map2k1 , Pik3ca , Tp53
blepharophimosisArid1b
blindnessVegfa
Bloch-Sulzberger syndromeIkbkg
bone development diseaseChuk , Tgfb2 , Tp53
bone diseaseTgfbr2
Bone FracturesTgfbr2
Bone Marrow NeoplasmsTp53
Bone NeoplasmsTgfbr2
brachydactylySmad4
brachydactyly type A1Shh
brain diseasePten , Tgfb1
brain edemaVegfa
Brain InjuriesAkt1 , Bad , Rela , Stat1 , Stat3 , Vegfa , Vegfb
brain ischemiaAkt1 , Bad , Bcl2l1 , Casp9 , Map2k1 , Mapk1 , Mapk3 , Mapk8 , Nfkb1 , Pgf , Rb1 , Rela , Stat3 , Tgfb1 , Tp53
Brain NeoplasmsBraf , Ccnd1 , Cdk4 , Cdkn2a , Egfr , Pik3ca , Pik3r1 , Pten , Rela , Tgfbr2 , Tp53 , Vegfa
Brain Stem NeoplasmsCdk4 , Cdk6 , Cdkn2a
breast adenocarcinomaAkt1 , Kras , Pik3ca , Tp53
breast cancerAkt1 , Braf , Brca2 , Erbb2 , Kras , Met , Nfkb1 , Pik3ca , Pten , Rad51 , Smad4 , Smarca4 , Stat1 , Tp53
Breast Cancer, FamilialBrca2 , Pik3r3 , Rad51 , Tp53
breast carcinomaBrca2
breast ductal carcinomaBrca2
Breast NeoplasmsAkt1 , Akt2 , Bad , Bcl2l1 , Braf , Brca2 , Casp9 , Ccnd1 , Cdk4 , Cdkn2a , E2f1 , Egf , Egfr , Erbb2 , Ikbkb , Kras , Map2k1 , Mapk1 , Met , Pgf , Pik3ca , Pik3r1 , Pten , Rad51 , Raf1 , Rb1 , Rela , Smad2 , Smad4 , Stat1 , Stat3 , Tgfb1 , Tp53 , Vegfa , Vegfb , Vegfc , Wnt9a
Breast-Ovarian Cancer, Familial, Susceptibility To, 1Brca2
Breast-Ovarian Cancer, Familial, Susceptibility To, 2Brca2
bronchiolo-alveolar adenocarcinomaCcnd1 , Egfr , Kras , Tp53
Bronchitis, ChronicVegfa
Brugada syndromeItga9
Bruton-type agammaglobulinemiaPik3r1
bullous pemphigoidVegfa
Burkitt lymphomaArid1a , Pik3r1 , Smarca4
BurnsBad , Ccnd1
CachexiaTgfb1
calcinosisErbb2 , Tgfb1
Camurati-Engelmann diseaseTgfb1
Candidiasis, Familial, 6Stat1
cannabis abuseAkt1
capillary hemangiomaAkt3
CarcinogenesisBraf , Cdkn2a , Erbb2 , Kras
carcinomaBcl2l1 , Ccnd1 , Cdc42 , Cdk4 , Egfr , Kras , Met , Pik3r1 , Pten , Rb1 , Stat3 , Tgfb1 , Tgfbr2 , Tp53
carcinosarcomaTgfb1
cardiac arrestAkt1
Cardiac FibrosisTgfb1
cardiofaciocutaneous syndromeBraf , Kras , Map2k1
Cardiofaciocutaneous Syndrome 2Kras
CARDIOFACIOCUTANEOUS SYNDROME 3Map2k1
CardiomegalyAkt1 , Bad , Egfr , Mapk1 , Mapk8 , Met , Pld1 , Pten , Rac1 , Raf1 , Rb1 , Rela , Stat3 , Tgfb1
cardiomyopathyAkt1 , Ilk , Kras , Mapk1 , Mapk3 , Rad51 , Stat3 , Tp53 , Vegfa
Cardiomyopathy, Hypertrophic, FamilialIlk , Kras , Raf1
CardiotoxicityRac1
Cardiovascular AbnormalitiesMap2k1
carotid artery diseasePgf , Tgfb1 , Tp53
cataractBrca2 , Map2k1 , Pten , Tp53
Cecal NeoplasmsCcnd1 , Kras , Tp53
Cell Transformation, NeoplasticCcnd1 , Egf , Kras , Mapk8 , Nfkb1 , Pten , Rac1 , Rela , Stat3 , Tgfb1 , Tp53
Central Nervous System NeoplasmsTp53
Cerebellar HypoplasiaArid1a
cerebral cavernous malformationPten
Cerebral HemorrhageBcl2l1 , Nfkb1 , Rela , Vegfa
cerebral infarctionItga9
cervical cancerTp53
cervix carcinomaTp53
cervix uteri carcinoma in situCcnd1 , Cdk4 , Cdkn2a , Pten , Rb1 , Rela , Stat3 , Vegfa
CHARGE syndromeTp53
Chemical and Drug Induced Liver InjuryBad , Tgfbr1 , Vegfa
Chemotherapy-Induced Febrile NeutropeniaTp53
Childhood SchizophreniaRela
ChloracneCdk6 , Egfr
cholangiocarcinomaArid1a , Egfr , Erbb2 , Kras , Met , Pbrm1 , Pten , Smad4 , Tgfb1 , Tgfbr2 , Tp53
cholangitisTgfb2
cholestasisRela
cholesteatomaVegfa
cholesteatoma of middle earRela , Tp53 , Vegfa
chorioamnionitisTgfb1
choroid plexus carcinomaTp53
choroid plexus papillomaTp53
Choroidal NeovascularizationIkbkb , Stat3 , Vegfa , Vegfb
Chromosome 17 DeletionTp53
Chromosome AberrationsCdk6
Chromosome DeletionCdkn2a
CHROMOSOME Xq26.3 DUPLICATION SYNDROMEArhgef6
chronic kidney diseaseShh
chronic lymphocytic leukemiaBraf , Kras , Tp53
Chronic Lymphocytic Leukemia, B-CellBraf , Itga4 , Kras , Tp53
chronic mucocutaneous candidiasisStat1
chronic myeloid leukemiaAkt1 , Bcl2l1 , Braf , Cdkn2a , E2f1 , Vegfa
chronic obstructive pulmonary diseaseBcl2l1 , Egfr , Mapk8 , Smad4 , Tgfb1 , Tp53 , Vegfa
Chronic PeriodontitisRac2
Churg-Strauss syndromeStat3
CicatrixSmad4
clear cell adenocarcinomaTp53
clear cell renal cell carcinomaPbrm1 , Vegfa
cleft palateChuk , Egf , Gli3 , Shh , Tgfb1 , Tgfb2 , Tgfb3
cleft soft palateTgfbr2
clubfootGli3
Cocaine-Related DisordersIlk , Mapk1 , Mapk3 , Smad3 , Smarca4
cocoon syndromeChuk
Coffin-Siris syndromeArid1a , Arid1b , Smarca4
Coffin-Siris syndrome 1Arid1b
Coffin-Siris syndrome 2Arid1a
Coffin-Siris syndrome 4Smarca4
Cognition DisordersMet , Smad4
colitisChuk , Ikbkb , Pgf , Rela
colon adenocarcinomaMapk1 , Mapk3 , Pik3r3 , Rac1 , Tgfb1
colon adenomaRac1
colon cancerAkt1 , Braf , Pik3ca , Tgfb3 , Tgfbr2 , Tp53
colon carcinomaAkt1 , Braf , Brca2 , Pik3ca , Tgfb1 , Tgfb2 , Tp53
Colonic NeoplasmsAkt2 , Akt3 , Bad , Braf , Ccnd1 , Cdkn2a , Egfr , Erbb2 , Ikbkb , Kras , Mapk8 , Mapk9 , Nfkb1 , Pik3ca , Pik3r1 , Pik3r2 , Pik3r5 , Pten , Rela , Stat3 , Tcf7l2 , Tgfbr2 , Tp53 , Vegfa , Vegfc
Colonic PolypsIlk
colorectal adenocarcinomaBcl2l1 , Mapk1 , Mapk3 , Mapk8 , Raf1 , Tp53
colorectal adenomaMapk8 , Raf1
colorectal cancerAkt1 , Arid1a , Braf , Pik3ca , Rac1 , Smad4 , Stat3 , Tcf7l2 , Tgfb1 , Tgfb2 , Tgfb3 , Tp53
Colorectal Cancer, Hereditary Nonpolyposis, Type 6Tgfbr2
Colorectal NeoplasmsAkt1 , Akt2 , Arid1a , Braf , Casp9 , Ccnd1 , Cdkn2a , Egfr , Erbb2 , Kras , Map2k1 , Mapk1 , Mapk3 , Met , Pik3ca , Pik3cd , Pik3r1 , Pik3r3 , Pten , Raf1 , Smad4 , Tcf7l2 , Tgfb1 , Tgfb2 , Tgfbr1 , Tp53
Combined Oxidative Phosphorylation Deficiency 11Tp53
common variable immunodeficiencyNfkb1
Common Variable Immunodeficiency 12Nfkb1
complex cortical dysplasia with other brain malformationsAkt3 , Pik3ca
congenital chylothoraxItga9
congenital diaphragmatic herniaGli3 , Lrp2 , Met , Tgfb1
Congenital Disorder of Glycosylation Type 1IBrca2
congenital heart diseaseTgfb2 , Vegfa
Congenital Limb DeformitiesChuk , Shh , Tgfb2
Congenital Lipomatous Overgrowth, Vascular Malformations, and Epidermal NeviPik3ca
congenital myasthenic syndrome 10Brca2
congenital myasthenic syndrome 4CPten
congestive heart failureErbb2 , Pgf , Rac1 , Tp53 , Vegfa
contact dermatitisVegfa
Copper-Overload CirrhosisMet , Smad2 , Stat3 , Tgfb1
corneal neovascularizationVegfa
coronary artery diseaseAkt1 , Tgfb1 , Vegfa
Coronary DiseaseTcf7l2 , Vegfa
coronary restenosisMapk1 , Tp53
coronin-1A deficiencyMapk3
Costello syndromeBraf , Kras , Map2k1
Cowden diseaseAkt1 , Egfr , Pik3ca , Pten
Cowden Syndrome 5Pik3ca
Cowden Syndrome 6Akt1
Cowden-Like SyndromeAkt1 , Pik3ca
Craniofacial AbnormalitiesEgfr , Lrp2 , Pten , Smad2 , Smad3 , Smad4 , Tgfb2 , Tgfbr2 , Tp53
craniopharyngiomaBraf
Crohn's diseasePgf , Smad3 , Stat3 , Vegfa
Cronkhite-Canada syndromeGli3 , Smad4
Crossed Polydactyly, Type IGli3
cryptorchidismArid1b , Bcl2l1 , Rela
Currarino TriadActl6a , Pik3ca
Cutaneous Malignant Melanoma, Susceptibility To, 1Akt1 , Braf , Brca2 , Cdk4 , Cdkn2a , Lrp2 , Map2k1 , Pik3ca , Pten , Rac1 , Raf1 , Tp53
cutaneous T cell lymphomaArid1a , Braf , Cdkn2a , Tp53
CyanosisTgfb2
cystic fibrosisTgfb1
cystitisRela
Cytomegalovirus InfectionsStat1
DeafnessSmad4
decubitus ulcerVegfa
degenerative disc diseaseTgfb1
dementiaE2f1 , Egfr
demyelinating diseaseShh , Tp53
dermatitisEgf , Egfr , Ikbkb
dermatitis herpetiformisVegfa
Developmental Cardiac Valvular DefectPld1
developmental coordination disorderPten
Developmental DisabilitiesActl6a , Akt3 , Braf , Lrp2 , Pik3r2 , Pten
Diabetes ComplicationsVegfa
diabetes mellitusPten , Rac1 , Tcf7l2
diabetic angiopathyRela , Vegfa
Diabetic CardiomyopathiesBad , Erbb2
Diabetic CystopathyBad
Diabetic NephropathiesEgf , Mapk1 , Pgf , Pten , Rela , Stat3 , Tcf7l2 , Tgfb1 , Tgfbr2 , Tp53 , Vegfa
diabetic neuropathyBad , Pgf , Tgfb1 , Tgfb2 , Tgfb3 , Vegfa
diabetic retinopathyCasp9 , Egfr , Itga4 , Pgf , Vegfa
Diamond-Blackfan anemiaTp53
Diaphyseal Dysplasia 1, ProgressiveTgfb1
diffuse large B-cell lymphomaCdkn2a , Gli1 , Pik3ca , Pik3cb , Pik3cd , Tp53
DiGeorge syndromeTgfbr2 , Vegfa
Dilatation, PathologicTgfb1
dilated cardiomyopathyEgfr , Erbb2 , Ilk , Kras , Pgf , Rac1 , Raf1
dilated cardiomyopathy 1BRaf1
dilated cardiomyopathy 1GBrca2
dilated cardiomyopathy 1NNRaf1
disease of cellular proliferationBraf , Cdkn2a , Erbb2 , Kras , Map2k1 , Met , Pik3ca , Pik3r1 , Pten , Rb1 , Tp53 , Vegfa
Disease ProgressionEgf , Egfr , Erbb2 , Pik3ca , Pten , Stat1 , Vegfb
Dissecting AneurysmSmad3 , Tgfbr1 , Tgfbr2
Donnai-Barrow syndromeLrp2
Drug-Induced DyskinesiaRela
Drug-induced NeutropeniaTp53
Drug-Related Side Effects and Adverse ReactionsTp53
dry eye syndromeTgfb1
Duchenne muscular dystrophyTgfb1
ductal carcinoma in situBrca2 , Ccnd1 , Erbb2 , Rb1 , Rela , Tp53 , Vegfa
duodenal ulcerStat3 , Tgfb1 , Vegfa
dysembryoplastic neuroepithelial tumorBraf
dyskeratosis congenitaTp53
dysplastic nevus syndromeCdkn2a , Pten
EdemaCasp9
Ehlers-Danlos syndromeTgfb1
embryonal carcinomaRb1
EmphysemaTp53
encephalitisRela
Encephalopathy, Neonatal Severe, due to Mecp2 MutationsIkbkg
end stage renal failureLrp2 , Nfkb1 , Pgf , Rela , Tgfb1
endometrial cancerEgf , Pik3cb , Pik3r1 , Pten , Tp53
endometrial carcinomaKras , Pik3ca , Pik3r1 , Pten
Endometrial HyperplasiaKras , Pten
Endometrial NeoplasmsAkt2 , Arid1a , Bad , Bcl2l1 , Braf , Brca2 , Ccnd1 , Cdk4 , Cdkn2a , Egf , Erbb2 , Kras , Mapk1 , Mapk3 , Met , Pik3ca , Pik3cb , Pik3cd , Pten , Rb1 , Smad2 , Smad3 , Smad4 , Stat3 , Tp53 , Vegfa
Endometrioid CarcinomasAkt1 , Egfr , Erbb2 , Kras , Pik3r2 , Pten
endometriosisBcl2l1 , Egfr , Kras , Tgfb2 , Vegfa
endomyocardial fibrosisTgfb1
EndotoxemiaPgf
eosinophilic esophagitisTgfb1
Epidermal HyperplasiaStat3
epidermal nevusKras , Pik3ca
epilepsyAkt1 , Ilk , Pgf , Rela , Tgfb1
erythema multiformeVegfa
esophageal atresia/tracheoesophageal fistulaBrca2 , Gli3 , Shh
esophageal cancerTgfbr2 , Tp53
esophageal carcinomaBrca2 , Cdkn2a , Egfr , Erbb2 , Kras , Pik3ca , Smad4 , Tp53
Esophageal NeoplasmsBrca2 , Ccnd1 , Cdkn2a , Egfr , Erbb2 , Kras , Met , Pik3ca , Smad4 , Tgfbr2 , Tp53
esophagus adenocarcinomaArid1a , Cdkn2a , Pik3ca , Smad4 , Tp53
esophagus squamous cell carcinomaBrca2 , Ccnd1 , Cdkn2a , Egfr , Rb1 , Tp53
essential thrombocythemiaTgfb1
Experimental ArthritisAkt1 , Cdc42 , Cdkn2a , Egfr , Gli1 , Ikbkb , Ikbkg , Itga4 , Pgf , Pik3cd , Shh , Stat1 , Stat3 , Tgfbr2 , Vegfa
Experimental Autoimmune EncephalomyelitisCasp9 , Gli1 , Itga4 , Shh , Stat1 , Stat3 , Tgfb1 , Tgfb2 , Vegfa
Experimental Autoimmune UveitisStat3
Experimental Autoimmune UveoretinitisStat3
Experimental ColitisItga4 , Smad4 , Vegfa
Experimental Diabetes MellitusAkt1 , Bad , Bcl2l1 , Casp9 , Egfr , Ikbkb , Lrp2 , Mapk1 , Mapk3 , Met , Pgf , Pik3r1 , Rela , Smarca4 , Stat1 , Stat3 , Tgfb1 , Tgfb2 , Tp53 , Vegfa , Vegfb
Experimental Liver CirrhosisCdk4 , Egf , Ilk , Met , Pgf , Rac2 , Rela , Smad2 , Smad4 , Tgfb1 , Tgfb3 , Tgfbr1 , Tgfbr2 , Vegfa
Experimental NeoplasmsBraf , Ccnd1 , Cdk4 , Erbb2 , Kras , Rb1 , Rela , Tp53 , Vegfa
Experimental SarcomaKras
extrahepatic cholestasisMapk1 , Mapk3 , Mapk8 , Mapk9 , Rela , Tgfb1
extrinsic allergic alveolitisVegfa
Eye AbnormalitiesShh , Tgfb2 , Tgfbr2
Facial AsymmetryPik3ca
Facial Dysmorphism with Multiple MalformationsShh
factor VIII deficiencyTgfb1
familial adenomatous polyposisAkt1 , Egfr
familial hypercholesterolemiaSmarca4
familial hyperlipidemiaTgfb1
familial meningiomaPten
familial partial lipodystrophyAkt2
Familial SchizencephalyShh
Familial Thoracic Aortic Aneurysm 1Tgfbr2
Familial Thoracic Aortic Aneurysm 3Tgfbr2
Fanconi anemiaBrca2
Fanconi anemia complementation group D1Brca2
Fanconi anemia complementation group RRad51
Fanconi syndromeLrp2
FatigueTgfbr2
fatty liver diseaseIkbkg , Mapk8 , Nfkb1 , Pten , Rela
Female InfertilityMapk1 , Mapk3 , Tp53
Ferguson-Smith tumorTgfbr1
fetal alcohol spectrum disorderPten
Fetal DiseasesChuk
FeverStat3
fibrosarcomaCdc42
FibrosisAkt1 , Stat3 , Tgfb1
Fluoride PoisoningGli1 , Shh
focal segmental glomerulosclerosisShh , Tgfb1
Follicular Thyroid CancerBraf , Pten
follicular thyroid carcinomaBraf , Kras , Pten
fundus dystrophyLrp2
Gallbladder NeoplasmsEgf , Egfr , Erbb2 , Kras , Met , Tgfa , Tgfb1 , Tp53
gangliosidosis GM1Brca2
gastric adenocarcinomaAkt1 , Braf , Cdkn2a , Erbb2 , Kras , Map2k1 , Pik3ca , Pten , Raf1 , Smad4 , Tp53
gastric ulcerBad , Bcl2l1 , Egf , Vegfa
gastrinomaMet
gastroenteritisTgfa
Gastrointestinal NeoplasmsErbb2 , Pik3ca , Pten , Smad4
gastrointestinal stromal tumorBoc , Braf , Gli1 , Gli3 , Kras , Rb1 , Tgfbr2
Gaucher's diseaseTp53
Generalized EpilepsyMapk10
genetic diseaseAkt2 , Akt3 , Arid1a , Arid1b , Braf , Brca2 , Cdc42 , Cdkn2a , Erbb2 , Ikbkg , Itga11 , Jak1 , Kras , Lrp2 , Map2k1 , Mapk1 , Pik3ca , Pik3r1 , Pik3r2 , Pld1 , Pten , Rad51 , Raf1 , Rala , Shh , Smad2 , Smad4 , Smarca4 , Stat1 , Stat3 , Tgfb2 , Tgfbr2
Genetic Predisposition to DiseaseEgf , Rad51 , Tgfa
Genomic InstabilityCcnd1
Germ Cell and Embryonal NeoplasmsCdk4 , Cdkn2a , Erbb2
germinomaBraf , Cdkn2a
gestational diabetesMet , Tcf7l2
Gilles de la Tourette syndromeMet
gingivitisVegfa
glaucomaBad , Cdkn2a , Tgfb2 , Vegfa
glioblastoma multiformeAkt1 , Akt3 , Braf , Cdk6 , Cdkn2a , Egf , Egfr , Erbb2 , Met , Pgf , Pik3ca , Pik3r1 , Pten , Tp53 , Vegfa
gliosarcomaVegfa
GliosisItga4 , Mapk1 , Mapk3
glomerulonephritisMapk1 , Vegfa
Glomus Tympanicum TumorVegfa
glucosephosphate dehydrogenase deficiencyIkbkg
Gonadal Dysgenesis, XX Type, with DeafnessBraf
grade III astrocytomaTp53
Graft vs Host DiseaseTp53 , Vegfa
Granuloma, PyogenicStat3
granulosa cell tumorCdkn2a , Vegfa
Graves' diseaseTp53 , Vegfa
Greig cephalopolysyndactyly syndromeGli3
Growth DisordersPik3ca
Growth Mental Deficiency Syndrome of MyhreSmad4
hairy cell leukemiaMap2k1
Head and Neck NeoplasmsBcl2l1 , Egfr , Mapk1 , Mapk3 , Pik3ca , Rad51 , Tgfa , Tp53 , Vegfa
head and neck squamous cell carcinomaAkt1 , Braf , Ccnd1 , Cdkn2a , Egfr , Erbb2 , Map2k1 , Mapk1 , Pik3ca , Pten , Rac1 , Smad4 , Stat3 , Tp53
Hearing LossBcl2l1 , Stat1
heart diseaseCasp9 , Rac2 , Stat3 , Tgfb1 , Vegfa
Heat StrokeNfkb1 , Rela
HELLP syndromeErbb2
hemangiomaPten
hematopoietic system diseaseBcl2l1 , Brca2
HemimegalencephalyPik3ca
Hepatitis C, ChronicStat3
Hepatitis, AnimalMet
Hepatitis, ChronicMet , Smad2 , Stat3 , Tgfb1
hepatoblastomaArid1a , Tgfa , Tp53
hepatocellular adenomaKras , Pten
hepatocellular carcinomaAkt1 , Akt2 , Arid1a , Arid1b , Bcl2l1 , Braf , Ccnd1 , Cdk4 , Cdkn2a , E2f1 , Egf , Egfr , Gli1 , Kras , Met , Pik3ca , Pten , Rac1 , Rb1 , Shh , Smad2 , Smad4 , Stat1 , Tgfa , Tgfb1 , Tgfbr2 , Tp53
HepatomegalyPten
Hereditary Adrenocortical CarcinomaTp53
hereditary breast ovarian cancer syndromeBrca2 , Tp53
Hereditary Eye DiseasesLrp2
hereditary hemorrhagic telangiectasiaSmad4
Hereditary Hemorrhagic Telangiectasia, Type 1Smad4 , Tgfb1
hereditary lymphedemaVegfc
Hereditary Neoplastic SyndromesBrca2 , Cdk4 , Cdkn2a , Met , Pik3ca , Pten , Rb1 , Smad4 , Smarca4 , Tp53
hereditary spastic paraplegia 11Brca2 , Tp53
hereditary spastic paraplegia 7Brca2
Hernias, Diaphragmatic, CongenitalStat3 , Vegfa
High MyopiaLrp2
Hirschsprung Disease 1Gli3 , Tgfb2
Hirschsprung's diseaseErbb2 , Shh , Tgfb2
holoprosencephalyBoc , Shh
holoprosencephaly 1Boc , Shh
holoprosencephaly 3Shh
Holt-Oram syndromeTgfb2
human immunodeficiency virus infectious diseaseCdc42
Human InfluenzaStat1
Huntington's diseaseCasp9 , E2f1 , Egfr , Nfkb1
hydrocephalusArid1b
Hyper-IgE Recurrent Infection Syndrome, Autosomal DominantStat3
HyperalgesiaMapk1 , Mapk3 , Mapk8 , Mapk9 , Raf1 , Stat3
Hyperbilirubinemia, NeonatalIkbkb
HypercholesterolemiaVegfa
hyperinsulinismPten
HyperoxaluriaNfkb1
HyperoxiaCdk4 , Tgfb1
Hyperoxic Lung InjuryShh
HyperparathyroidismCcnd1
HyperplasiaAkt1 , Ccnd1 , Cdkn2a , Egfr , Ikbkb , Pik3ca , Tcf7l2 , Tgfb1 , Tgfbr2 , Vegfa
Hypersensitivity, ImmediateEgfr
hypertensionAkt1 , Akt2 , Arid1b , Bad , Cdkn2a , Egfr , Ikbkb , Itga9 , Kras , Lrp2 , Mapk8 , Pgf , Pik3r1 , Pten , Rad51 , Ralbp1 , Rela , Tgfb1 , Tgfb3 , Tp53 , Vegfa
hypertrichosisArid1b
hypertrophic cardiomyopathyRaf1 , Tgfb1 , Tgfb3 , Tp53
hypertrophic cardiomyopathy 4Braf
hypertrophic cardiomyopathy 9Brca2
HypertrophyMapk1 , Mapk3 , Pten
Hypertrophy, Left VentricularEgfr , Pbrm1 , Pten , Rac1 , Rela , Smarca4
Hypertrophy, Right VentricularAkt1 , Tgfa , Tgfb1
hyperuricemiaStat3
Hypoglossal Nerve InjuriesSmad2 , Smad3 , Smad4
hypoglycemiaAkt2 , Pik3r1
hypohidrotic ectodermal dysplasiaIkbkg
Hypohidrotic Ectodermal Dysplasia, with Immune DeficiencyIkbkg
Hypoinsulinemic Hypoglycemia with HemihypertrophyAkt2
hypomyelinating leukodystrophy 8 with or without oligodontia and-or hypogonadotropic hypogonadismPik3r2
HypopigmentationGli3
hypospadiasGli3
Hypothalamic HamartomasGli3
hypothyroidismBad , Shh
hypotrichosis 8Rb1
HypoxiaPgf , Rad51
Hypoxia-Ischemia, BrainBcl2l1 , Vegfa
idiopathic pulmonary fibrosisStat3
IgA glomerulonephritisShh , Tgfb1
Immunodeficiency 14Pik3cd
Immunodeficiency 15Ikbkb
IMMUNODEFICIENCY 31AStat1
IMMUNODEFICIENCY 31BStat1
IMMUNODEFICIENCY 31CStat1
Immunodeficiency 36Pik3r1
Immunodeficiency without Anhidrotic Ectodermal DysplasiaIkbkg
impotenceAkt1 , Bad , Bcl2l1 , Ccnd1 , Tgfb1 , Vegfa
in situ carcinomaAkt1 , Cdkn2a , Pten , Rb1
inclusion body myopathy with Paget disease of bone and frontotemporal dementiaEgf
Infant, Newborn, DiseasesTgfb1
infertilityBrca2
InflammationAkt1 , Chuk , Egfr , Pgf , Stat3 , Tgfa , Tgfb1 , Vegfa
inflammatory bowel diseaseIkbkb , Itga4 , Stat3 , Tgfb1 , Vegfa
inguinal herniaTgfbr2
Insulin ResistanceAkt2 , Bad , Egfr , Ikbkb , Pik3r1 , Pten , Rb1 , Rela , Tcf7l2
insulinomaTgfa , Tgfb1
intellectual disabilityArhgef6 , Arid1b , Kras , Pten , Ralgds
intermediate coronary syndromeAkt1
intermittent claudicationBad
interstitial lung diseaseTgfb1
Intervertebral Disc DisplacementAkt1
Intestinal NeoplasmsMap2k1 , Mapk8
Intestinal PolypsCcnd1
intestinal pseudo-obstructionPten , Rb1
intrahepatic cholangiocarcinomaKras
invasive ductal carcinomaAkt1 , Cdkn2a , Erbb2 , Smad4
invasive lobular carcinomaCcnd1 , Erbb2
Invasive Pneumococcal Disease, Recurrent Isolated, 2Ikbkg
Invasive Pulmonary AspergillosisVegfa
inverted papillomaVegfa
irritable bowel syndromeIkbkg
irritant dermatitisStat3
ischemiaAkt2 , Arid1b , Mapk9 , Raf1 , Tp53
ischemic colitisVegfa
isolated growth hormone deficiency type IABrca2
Job's syndromeStat3
Joubert syndrome 9Braf
juvenile myelomonocytic leukemiaKras , Rac2
juvenile polyposis syndromeSmad4
Juvenile Polyposis with Hereditary Hemorrhagic TelangiectasiaSmad4
juvenile rheumatoid arthritisEgf , Kras , Mapk1 , Smad3 , Stat3 , Tcf7l2
Kaposi's sarcomaTp53
Kawasaki diseaseVegfa
keratosisTp53
kidney diseaseArid1b , Egf , Lrp2 , Mapk1 , Tgfb1 , Tgfbr1 , Tgfbr2
Kidney NeoplasmsAkt1 , Braf , Ccnd1 , Cdkn2a , Erbb2 , Kras , Mapk1 , Mapk3 , Met , Raf1
Kidney Reperfusion InjuryIkbkb , Shh
Kuhnt-Junius degenerationMapk8 , Vegfa
Language Development DisordersActl6a , Pten
large cell carcinomaMet
Laryngeal NeoplasmsEgfr
Laryngotracheal Stenosis, Progressive, with Short Stature and ArthropathySmad4
learning disabilityIkbkg , Vegfa
Leber hereditary optic neuropathyTp53
left ventricular noncompactionTgfb3
leiomyomaBcl2l1 , Pten , Smad3 , Tgfbr1
leiomyosarcomaCdkn2a
Lennox-Gastaut syndromeMapk10
LEOPARD syndromeBraf , Pten , Raf1
LEOPARD SYNDROME 3Braf
LEOPARD Syndrome, 2Raf1
leukemiaBad , Ccnd1 , Cdkn2a , Pten , Tp53
Leukemia, ExperimentalCdkn2a
LeukocytosisItga4 , Kras
Leydig cell tumorCdk4
Li-Fraumeni syndromeTp53
Li-Fraumeni Syndrome 2Tp53
Li-Fraumeni Syndrome 3Tp53
Li-Fraumeni-Like SyndromeTp53
Limb IschemiaVegfa
limited sclerodermaPgf
Lip NeoplasmsTp53
lipomaPten
lipomatosisPten
liposarcomaCdk4
Lipoyltransferase 1 DeficiencyTgfbr2 , Tp53
liver cancerAkt1 , Cdkn2a , Kras , Pik3ca , Tp53
liver cirrhosisPgf , Smad3 , Stat1 , Stat3 , Tgfb1 , Tgfbr1 , Vegfa
liver diseaseBcl2l1 , Nfkb1 , Rac1
Liver FailureVegfa
Liver InjuryStat3
liver neoplasmBraf , Ccnd1 , Cdkn2a , Kras , Met , Raf1 , Stat3 , Tgfa , Tp53
Liver Neoplasms, ExperimentalBcl2l1 , Ccnd1 , Kras , Map2k1 , Mapk1 , Mapk3 , Met , Rad51 , Rb1 , Stat3 , Tgfa , Tgfb1 , Tp53
Liver Reperfusion InjuryBad , Bcl2l1 , Ikbkg , Mapk8
localized sclerodermaTgfb1
Loeys-Dietz syndromeSmad3 , Tgfb2 , Tgfb3 , Tgfbr1 , Tgfbr2
LOEYS-DIETZ SYNDROME 2Tgfbr2
Loeys-Dietz Syndrome 3Smad3
Loeys-Dietz Syndrome 4Tgfb2 , Tgfb3
Loeys-Dietz Syndrome 5Tgfb3
Loeys-Dietz Syndrome, Type 1bTgfbr2
Loeys-Dietz Syndrome, Type 2ATgfbr1
long QT syndromeIlk , Pten
low tension glaucomaTp53
lung adenocarcinomaAkt1 , Braf , Ccnd1 , Cdk4 , Cdk6 , Cdkn2a , E2f1 , E2f3 , Egf , Egfr , Erbb2 , Kras , Map2k1 , Pik3ca , Pik3r1 , Raf1 , Smad4 , Tp53
lung cancerBraf , Egfr , Erbb2 , Kras , Pik3ca
lung diseaseEgfr , Tgfb1 , Vegfa
Lung InjuryTgfa
Lung NeoplasmsAkt1 , Bcl2l1 , Braf , Brca2 , Ccnd1 , Cdkn2a , Egfr , Erbb2 , Ikbkg , Kras , Mapk1 , Mapk3 , Met , Pik3ca , Pten , Raf1 , Smarca4 , Tgfb1 , Tgfbr2 , Tp53
lung small cell carcinomaAkt1 , Ccnd1 , E2f1 , Egfr , Pik3ca , Pten , Rb1 , Smarca4 , Tp53
lung squamous cell carcinomaAkt1 , Braf , Ccnd1 , Cdk4 , Cdkn2a , E2f1 , E2f3 , Egfr , Kras , Pik3ca , Pten , Tp53
lupus nephritisEgf
LymphangiectasisRaf1
lymphangioleiomyomatosisStat1 , Stat3 , Vegfd
Lymphatic MetastasisCasp9 , Egfr , Erbb2 , Pik3ca , Pik3cb , Pten , Rela , Smad4 , Stat3 , Tp53 , Vegfa , Vegfc , Vegfd
lymphedemaPgf
LYMPHEDEMA, HEREDITARY, IDVegfc
lymphoid leukemiaBcl2l1
lymphomaCdkn2a , Kras , Pten , Rac2 , Rela , Tp53
lymphoproliferative syndromeStat3
Lynch syndromeSmad2 , Smad3 , Smad4 , Tgfbr1 , Tgfbr2
macrocephaly-autism syndromePten
Macrocephaly/Megalencephaly Syndrome, Autosomal RecessiveAkt3
macular degenerationBad , Vegfa
macular retinal edemaVegfa
male breast cancerBrca2
Male Breast NeoplasmsBrca2
male infertilityTp53
Malformations of Cortical Development, Group IIPten
malignant gliomaAkt2 , Bad , Braf , Brca2 , Ccnd1 , Cdkn2a , Egfr , Erbb2 , Met , Pik3ca , Pten , Raf1 , Tp53
malignant mesotheliomaCdk6 , Cdkn2a , Egfr , Ilk , Met , Raf1 , Tgfb2 , Tp53
Mammary Neoplasms, AnimalCcnd1 , Cdc42 , Cdk4 , Egfr , Erbb2 , Pik3r1 , Rb1 , Stat3 , Tgfa
Mammary Neoplasms, ExperimentalAkt1 , Akt2 , Bad , Bcl2l1 , Casp9 , Ccnd1 , Cdc42 , Cdk4 , Cdk6 , Cdkn2a , Egfr , Erbb2 , Ilk , Pik3r1 , Pten , Rb1 , Rela , Stat1 , Stat3 , Tgfa , Tgfb1 , Tgfbr1 , Tgfbr2 , Tp53 , Vegfa
mammary Paget's diseaseErbb2
Mandibular NeoplasmsBraf
mantle cell lymphomaCcnd1 , Pik3cd
Marfan syndromeTgfbr2
marginal zone B-cell lymphomaTp53
mastoiditisRela
median neuropathyErbb2
medulloblastomaArid1a , Arid1b , Brca2 , Ccnd1 , Cdk6 , Erbb2 , Pik3ca , Rb1 , Smarca4 , Stat3 , Tp53
Megakaryoblastic Leukemia of Down SyndromeTp53
megakaryocytic leukemiaPten , Tp53
Megalancephaly Polymicrogyria-Polydactyly Hydrocephalus SyndromeAkt3 , Pik3ca , Pik3r2
MegalencephalyAkt3 , Gli3 , Pten
Megalencephaly Cutis Marmorata Telangiectatica CongenitaAkt3 , Pik3ca , Pik3r2
MEGALENCEPHALY-POLYMICROGYRIA-POLYDACTYLY-HYDROCEPHALUS SYNDROME 2Akt3
melanomaAkt1 , Bcl2l1 , Braf , Brca2 , Cdk4 , Cdkn2a , E2f1 , Erbb2 , Kras , Lrp2 , Map2k1 , Nfkb1 , Pik3ca , Pik3r1 , Pten , Rac1 , Rac2 , Raf1 , Tp53 , Vegfa , Vegfc
Melanoma Astrocytoma SyndromeCdkn2a
Melanoma, Cutaneous Malignant, Susceptibility To, 2Cdkn2a
Melanoma, Cutaneous Malignant, Susceptibility To, 3Cdk4
Melanoma, ExperimentalIkbkb
Melanoma-Pancreatic Cancer SyndromeCdkn2a
membranoproliferative glomerulonephritisTgfbr2
membranous glomerulonephritisLrp2 , Shh
Memory DisordersStat3 , Vegfa
Meningeal NeoplasmsAkt1
meningiomaAkt1 , Pten
mental depressionBcl2l1
Mental Retardation, X-Linked 46Arhgef6
MesotheliomaCdkn2a , Egfr , Tp53
Metabolic Bone DiseasesLrp2
Metabolic SyndromeTgfb1 , Vegfa
MetaplasiaEgf
Micronuclei, Chromosome-DefectiveCdkn2a , Rad51
microphthalmiaRalbp1
Microphthalmia, Cataracts, and Iris AbnormalitiesSmad4
Microphthalmia, Isolated, with Coloboma 5Shh
Microsatellite InstabilityArid1a , Braf , Tgfbr2
Microvascular Complications of Diabetes, Susceptibility to, 1Vegfa
Microvascular Complications of Diabetes, Susceptibility to, 2Vegfa
Microvascular Complications of Diabetes, Susceptibility to, 7Vegfa
microvillus inclusion diseaseCdc42
middle cerebral artery infarctionBad , Ikbkb , Pld1 , Shh , Stat3
migraineTgfbr2
Mirror Movements 2Rad51
Mixed Tumor, MullerianCdkn2a
Miyoshi Muscular Dystrophy 3Brca2
Mouth NeoplasmsCdkn2a , Erbb2 , Kras , Pik3ca , Pten , Tp53
mucositisTgfa
Multiple AbnormalitiesArid1b , Cdc42 , Chuk , Kras , Mapk1 , Pik3r2 , Pld1 , Pten , Smad2 , Smarca4
multiple acyl-CoA dehydrogenase deficiencyBrca2
Multiple Hamartoma SyndromePik3ca , Pten
multiple myelomaBcl2l1 , Braf , Ccnd1 , Cdk4 , Cdkn2a , Kras , Met , Pik3ca , Tgfb1 , Tp53 , Vegfa
Multiple Organ FailureMapk1
multiple sclerosisGli1 , Shh , Vegfa
Multisystem Autoimmune Disease, Infantile-OnsetStat3
muscular atrophyAkt1 , Chuk , Ikbkb
muscular diseaseSmad4 , Tgfb1
muscular dystrophyPten
Musculoskeletal AbnormalitiesTgfb2
Mycobacterium InfectionsStat1
myelodysplastic syndromeCdkn2a , Kras , Tp53
myelofibrosisTgfb1 , Tp53
myeloid leukemiaVegfa
myeloid neoplasmKras
myeloid sarcomaKras
myocardial infarctionAkt1 , Bcl2l1 , Mapk1 , Pgf , Shh , Smad2 , Smad4 , Tgfb1 , Tgfb2 , Tgfbr1 , Tgfbr2 , Tp53 , Vegfa , Vegfb
Myocardial IschemiaCcnd1 , Erbb2 , Pgf , Ralbp1 , Vegfa
Myocardial Reperfusion InjuryAkt1 , Akt2 , Bad , Bcl2l1 , Casp9 , Mapk1 , Mapk8 , Pten , Rela , Shh , Smad3 , Smad4 , Stat1 , Stat3 , Tgfb1 , Tp53 , Vegfa
Myoclonic EpilepsiesBrca2
Myoclonic Epilepsy, Familial InfantileBrca2
Nasal PolypsMet , Stat3 , Tgfb1 , Vegfa
Nasopharyngeal NeoplasmsCcnd1 , Egfr , Pik3ca , Tp53
nasopharynx carcinomaAkt2 , Arid1a , Ccnd1 , Cdkn2a , Erbb2 , Kras , Pik3ca , Pten , Tp53
NecrosisCdc42
Nematode InfectionsPik3r1
Neonatal Inflammatory Skin and Bowel Disease 2Egfr
Neoplasm InvasivenessCdkn2a , Egf , Egfr , Mapk1 , Mapk3 , Met , Pten , Rela , Tgfb1
Neoplasm MetastasisAkt2 , Braf , Ccnd1 , Cdkn2a , Chuk , Egf , Egfr , Erbb2 , Kras , Mapk1 , Mapk3 , Mapk9 , Met , Nfkb1 , Pik3ca , Pik3r3 , Pten , Rac1 , Rb1 , Stat1 , Stat3 , Tgfb1 , Tgfbr1 , Tgfbr2 , Tp53 , Vegfa
Neoplasm Recurrence, LocalEgfr , Erbb2 , Vegfa
Neoplasms, Cystic, Mucinous, and SerousMet
neovascular glaucomaVegfa
Neovascularization, PathologicVegfa
nephritisItga4
nephroblastomaArid1a , Bcl2l1 , Brca2 , Cdk4 , Cdkn2a , Erbb2 , Stat1 , Stat3 , Tp53 , Vegfc
nephrolithiasisTgfb1
nephrosisLrp2
nephrotic syndromeTgfb1
Nerve DegenerationMapk1 , Mapk3 , Tgfa , Vegfa
Nerve Sheath NeoplasmsCdkn2a , Met , Pten , Tp53
nervous system diseaseCasp9 , Tp53
neural tube defectGli3
NeuralgiaTgfb1
neurilemmomaCdkn2a
neuroblastomaArid1a , Arid1b , Brca2 , Cdkn2a , Kras , Met , Pik3ca , Tp53
Neurodevelopmental DisordersArid1b , Pten , Tcf7l2
neuroendocrine tumorBraf
Neurofibromatosis 1Vegfa
Neurofibromatosis 2Vegfa
neurofibrosarcomaVegfa
neuronal ceroid lipofuscinosisBraf
neuronal ceroid lipofuscinosis 6Braf , Mapk1 , Mapk3
neuronal ceroid lipofuscinosis 8Tgfbr2
neutropeniaStat3
Neutrophil Immunodeficiency SyndromeRac2
nevoid basal cell carcinoma syndromeGli1 , Shh
NevusBraf
newborn respiratory distress syndromeVegfa
Nicolaides Baraitser SyndromeArid1b
Niemann-Pick disease type C1Stat3
non-Hodgkin lymphomaBraf , Ccnd1 , Map2k1 , Pik3ca , Tp53
non-small cell lung carcinomaAkt1 , Akt2 , Akt3 , Bad , Braf , Casp9 , Ccnd1 , Cdk4 , Cdk6 , Cdkn2a , E2f1 , E2f3 , Egf , Egfr , Erbb2 , Kras , Map2k1 , Met , Pik3ca , Pten , Raf1 , Rb1 , Rela , Stat3 , Tgfa , Tp53 , Vegfa
non-syndromic X-linked intellectual disabilityArhgef6
nonalcoholic fatty liver diseaseIkbkg , Mapk8 , Stat3 , Tgfb1
Nonseminomatous Germ Cell TumorBraf
Nonspherocytic Hemolytic Anemia, due to G6PD DeficiencyIkbkg
nonsyndromic deafnessMet , Tgfa , Tgfb3
Nontuberculous Mycobacterium InfectionsStat1
Noonan Like SyndromeCdc42
Noonan syndromeBraf , Kras , Map2k1 , Raf1
Noonan syndrome 1Braf , Map2k1
Noonan syndrome 3Kras , Raf1
Noonan syndrome 5Raf1
Noonan syndrome 7Braf
Nose NeoplasmsTp53
obesityAkt1 , Akt2 , Bad , Cdk4 , Cdkn2a , Egfr , Ikbkb , Pgf , Pik3r1 , Rb1 , Rela , Smarca4 , Stat3 , Tgfb1
obstructive sleep apneaRela
Occupational DiseasesTgfb1
ocular hypertensionBcl2l1 , Gli1 , Shh
oculocutaneous albinism type IVBrca2
Odontogenic CystsSmad4
Odontogenic MyxomaTp53
Oral Lichen PlanusTp53
oral mucosa leukoplakiaTp53
oral squamous cell carcinomaMet
oral submucous fibrosisTgfb1 , Tp53
Oropharyngeal NeoplasmsTp53
Ossification, HeterotopicSmad4
osteoarthritisBad , Cdkn2a , Smad3
Osteoarthritis, KneeTgfa
osteochondrodysplasiaPten , Tgfb1 , Tgfb2 , Tgfbr1 , Vegfa
Osteofibrous DysplasiaMet
osteogenesis imperfectaSmad4
osteoporosisTgfb1
Osteoporosis, PostmenopausalTgfb1
osteosarcomaAkt1 , Brca2 , Egfr , Met , Rb1 , Tp53 , Vegfa
otitis mediaRela , Vegfa
Otitis Media with EffusionVegfa
ovarian cancerAkt1 , Brca2 , Egf , Erbb2 , Kras , Pik3ca , Tp53
ovarian cystNfkb1
Ovarian NeoplasmsAkt1 , Akt2 , Bcl2l1 , Braf , Brca2 , Ccnd1 , Cdk4 , Cdkn2a , Egfr , Erbb2 , Ilk , Kras , Map2k1 , Mapk1 , Mapk3 , Met , Pik3ca , Pik3r1 , Pten , Rad51 , Rb1 , Rela , Smad2 , Smad4 , Smarca4 , Stat3 , Tp53 , Vegfa , Vegfc , Vegfd
ovarian serous cystadenocarcinomaBraf , Erbb2 , Pik3ca , Tp53
ovary adenocarcinomaErbb2
ovary epithelial cancerTp53
Oxygen-Induced RetinopathyMapk8 , Stat3 , Vegfa
PainAkt1
Pallister-Hall syndromeGli3
pancreatic acinar cell adenocarcinomaBraf
pancreatic adenocarcinomaCcnd1 , Cdkn2a , Erbb2 , Kras , Pik3ca , Smad4 , Tp53
pancreatic cancerAkt1 , Akt2 , Akt3 , Arid1a , Arid1b , Bad , Bcl2l1 , Boc , Braf , Brca2 , Casp9 , Ccnd1 , Cdc42 , Cdk4 , Cdkn2a , Egf , Egfr , Gli1 , Gli3 , Ilk , Itga11 , Itga4 , Itga9 , Kras , Lrp2 , Met , Pbrm1 , Pten , Rad51 , Rb1 , Rela , Shh , Smad3 , Smad4 , Smarca4 , Stat3 , Tcf7l2 , Tgfa , Tgfb1 , Tgfbr2 , Tp53 , Vegfb , Wnt9a
pancreatic carcinomaCdkn2a , Kras , Smad4 , Tp53
pancreatic ductal adenocarcinomaCcnd1
pancreatic ductal carcinomaCcnd1 , Cdkn2a , Egf , Kras , Met , Tgfb1 , Tgfbr2 , Vegfa
pancreatic intraductal papillary-mucinous neoplasmAkt1
Pancreatic Intraepithelial NeoplasiaCcnd1
pancreatic solid pseudopapillary carcinomaCcnd1
pancreatitisEgf , Ikbkb , Met
Pancreatitis, Acute NecrotizingRela
Pancreatitis, ChronicBad
Pancreatitis, ExperimentalIkbkg
Pancreatitis, Experimental, Acute Bcl2l1 , Kras
Pancreatitis, Experimental, Chronic Gli1
papillary carcinomaVegfc
papillary renal cell carcinomaMet
Papillary Thyroid CancerBraf
papillary thyroid carcinomaBraf
papillomaCcnd1 , Egfr , Erbb2 , Tgfa , Tgfb1
Papillomavirus InfectionsCdkn2a
paranasal sinus neoplasmTp53
paraplegiaAkt1
Paraquat LungTgfb1
Parasitic Liver DiseasesKras , Smad4 , Tp53
Parkinson's diseaseAkt1 , Casp9 , Egf , Egfr , Erbb2
Parkinsonian DisordersBad , Casp9 , Egfr , Rela , Shh
Patterson Stevenson SyndromeShh
Pediatric Adrenocortical CarcinomaTp53
Pena Shokeir Syndrome, Type 1Pten
penile neoplasmCcnd1 , Kras , Pik3ca , Tp53
peptic esophagitisEgfr
perinatal necrotizing enterocolitisEgf , Ikbkg
Periodontal AtrophyVegfa
periodontitisMet
peripartum cardiomyopathyStat3
Peripheral Nerve InjuriesShh
peripheral nervous system diseaseCasp9 , Cdkn2a , Gli1
peripheral nervous system neoplasmPten
Peritoneal FibrosisTgfb1
Persistent CloacaShh
persistent fetal circulation syndromePten
persistent hyperplastic primary vitreousCdkn2a
Peyronie's diseaseTgfb1
Phyllodes TumorEgfr , Rb1 , Tp53
piebaldismGli3
pilocytic astrocytomaKras
Pituitary NeoplasmsRb1
plasma cell neoplasmBcl2l1
plasmacytomaBraf , Cdk4 , Cdkn2a , Kras , Pik3ca , Tp53
pleomorphic xanthoastrocytomaBraf , Cdk6 , Egfr , Gli3 , Met , Rala
pleural diseaseTgfb1
Pneumococcal MeningitisRela
Pneumococcal PneumoniaMapk1 , Mapk3
pneumoniaEgf , Ikbkb , Itga4 , Tgfb1
PoisoningCdkn2a
polyarteritis nodosaVegfa
polycystic ovary syndromeAkt2 , Vegfa
polycythemia veraBcl2l1 , Jak1
polydactylyGli3 , Pten , Shh
Polydactyly, PostaxialGli3
Polydactyly, Preaxial 4Gli3
Polydactyly, Preaxial IIShh
PolymicrogyriaAkt3
PolyploidyTp53
Polypoidal Choroidal VasculopathyVegfa
portal hypertensionPik3r1 , Pten , Vegfa
Posterior Leukoencephalopathy SyndromeTgfb1
pre-eclampsiaErbb2 , Itga4 , Pgf , Vegfa
pre-malignant neoplasmAkt1 , Ccnd1 , Cdkn2a , Egf , Mapk8 , Mapk9 , Smad3 , Smad4 , Stat3 , Tp53 , Vegfa
precursor B lymphoblastic lymphoma/leukemiaBcl2l1 , Ccnd1 , Cdkn2a , Stat3 , Tp53
precursor lymphoblastic lymphoma/leukemiaBcl2l1 , Ccnd1 , Cdk6 , Cdkn2a , Kras , Rb1 , Tp53
precursor T-lymphoblastic lymphoma/leukemiaCdkn2a , Kras , Smarca4 , Stat1
Pregnancy in DiabeticsVegfa
Premature AgingCdkn2a , Tp53
Premature BirthPgf
PRIMARY AUTOSOMAL RECESSIVE MICROCEPHALY 12Cdk6
primary biliary cirrhosisNfkb1
primary hypomagnesemiaEgf
primary open angle glaucomaTp53
primary progressive multiple sclerosisShh
primary pulmonary hypertensionSmad4
prolactinomaLrp2
proliferative diabetic retinopathyVegfa
prostate adenocarcinomaAkt1 , Akt2 , Akt3 , Braf , Cdkn2a , Chuk , Erbb2 , Ikbkb , Map2k1 , Mapk1 , Pik3ca , Pik3cb , Pten , Raf1 , Rela , Smad4 , Tp53
prostate cancerAkt2 , Akt3 , Brca2 , Chuk , E2f1 , E2f3 , Erbb2 , Gli1 , Ikbkb , Kras , Mapk10 , Nfkb1 , Pik3ca , Pik3cb , Pik3r1 , Pik3r2 , Pten , Rac2 , Raf1 , Tcf7l2 , Tgfbr2 , Tp53
Prostate Cancer, SomaticPten
prostate carcinomaAkt2
prostate carcinoma in situCcnd1 , Kras , Pten , Rela , Smad4
prostatic hypertrophyBad , Cdk4 , Pten , Rela
Prostatic NeoplasmsAkt1 , Arid1a , Bad , Bcl2l1 , Braf , Brca2 , Casp9 , Ccnd1 , Cdk4 , Cdkn2a , Chuk , Egf , Egfr , Erbb2 , Ilk , Jak1 , Kras , Lrp2 , Map2k1 , Mapk3 , Met , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pten , Ralbp1 , Rb1 , Rela , Smad3 , Smad4 , Smarca4 , Stat1 , Stat3 , Tgfa , Tgfb1 , Tgfbr2 , Tp53 , Vegfa
prostatitisSmad4
proteinuriaTgfb1 , Vegfa
Proteus syndromeAkt1 , Pten
Pseudovaginal Perineoscrotal HypospadiasBrca2
pseudoxanthoma elasticumVegfa
psoriasisIkbkb , Stat3 , Tgfa , Tgfb1 , Tp53 , Vegfa
psoriatic arthritisStat3
PTEN hamartoma tumor syndromePik3ca , Pten
pterygiumTp53 , Vegfa , Vegfc
pulmonary edemaTgfa , Vegfa
pulmonary emphysemaPgf , Tgfb1
pulmonary fibrosisBad , Egf , Egfr , Smad4 , Stat1 , Stat3 , Tgfa , Tgfb1 , Tgfbr2
pulmonary hypertensionBcl2l1 , Egfr , Pgf , Rela , Smad4 , Tgfa , Tgfb1 , Tgfbr1 , Tgfbr2 , Tp53 , Vegfb
pulmonary sarcoidosisTgfb1
pulmonary valve stenosisBraf
pyelonephritisPgf
Radiation InjuriesTgfbr2
Radiation Injuries, ExperimentalMapk1 , Mapk3
Radiation PneumonitisTgfb1
RASopathiesBraf , Kras , Map2k1 , Raf1
rectal neoplasmEgfr , Mapk8 , Pik3ca , Pik3cb
RecurrenceErbb2 , Kras , Vegfc
renal carcinomaMet , Pik3ca , Pten , Tp53
renal cell carcinomaAkt1 , Akt3 , Bad , Bcl2l1 , Ccnd1 , Cdk4 , Cdkn2a , Egfr , Erbb2 , Kras , Map2k1 , Mapk1 , Met , Pbrm1 , Pgf , Pik3ca , Pik3r1 , Pten , Rb1 , Rela , Smad2 , Smad4 , Stat3 , Tgfb1 , Tp53 , Vegfa , Vegfc
renal fibrosisKras , Mapk1
renal hypomagnesemia 3Egf
renal hypomagnesemia 4Egf
renal hypomagnesemia 5 with ocular involvementEgf
renovascular hypertensionRela
Reoviridae InfectionsStat1
Reperfusion InjuryAkt1 , Bad , Casp9 , Ccnd1 , Cdc42 , Egf , Mapk8 , Mapk9 , Met , Pik3r1 , Pten , Rela , Stat1 , Stat3 , Tgfbr2 , Tp53 , Vegfc , Vegfd
Respiratory System AbnormalitiesTgfb2 , Tgfb3
Retina Reperfusion InjuryBad , Bcl2l1 , Stat3 , Vegfa
retinal detachmentCasp9
retinal diseaseVegfa
retinal ischemiaVegfa
Retinal NeovascularizationVegfa , Vegfb
retinal telangiectasiaVegfa
retinal vein occlusionVegfa , Vegfb
retinitis pigmentosaItga4 , Pten , Vegfa
retinitis pigmentosa 26Brca2 , Itga4
retinoblastomaRb1
retinopathy of prematurityVegfa
Rhabdoid Tumor Predisposition Syndrome 2Smarca4
rhabdomyosarcomaBrca2 , Cdkn2a , Tp53 , Vegfa
rheumatoid arthritisCdk6 , Pgf , Stat1 , Stat3 , Vegfa
rhinitisCdc42 , Tgfb1 , Vegfa
Salivary Gland NeoplasmsCcnd1
sarcoidosisTgfb1
sarcomaMet , Pik3ca , Smarca4 , Tp53
Sarcoma Family Syndrome of Li and FraumeniTp53
SchizencephalyShh
schizophreniaAkt1 , Egf , Egfr , Mapk3 , Met , Pik3cb , Tp53
scrapieStat1 , Stat3
Seasonal Allergic RhinitisVegfa
Sebaceous Nevus of JadassohnKras
Sebaceous Nevus Syndrome and HemimegalencephalyKras
seborrheic keratosisPik3ca
secondary Parkinson diseaseShh
seminomaKras , Rb1 , Smad4 , Vegfa
Senior-Loken syndromeAkt3
Senior-Loken Syndrome 7Akt3
Sensenbrenner syndromeTgfb3
sensorineural hearing lossLrp2
SepsisBad , Itga4 , Mapk1 , Mapk3 , Pgf , Rela , Stat1 , Stat3 , Tgfb1
Sepsis-Associated EncephalopathyStat3
Septic PeritonitisPik3r1
serous cystadenocarcinomaTp53
Sezary's diseaseArid1a , Braf , Cdkn2a , Mapk1 , Pten , Rb1 , Smarca4 , Tp53
Shock, HemorrhagicBad , Bcl2l1 , Mapk1 , Rela
SHORT SyndromePik3r1
sickle cell anemiaPgf , Tgfb1
Single Upper Central IncisorShh
sinusitisMet
Sjogren's syndromeE2f1 , Tgfb1
Skin AbnormalitiesChuk
skin cancerChuk
skin diseasePten
skin melanomaBrca2 , Cdk4 , Cdkn2a , Pten , Stat3
Skin NeoplasmsAkt1 , Rela , Stat3 , Tgfb1 , Tgfbr1 , Tp53 , Vegfa
small cell carcinomaRb1 , Smarca4 , Tp53
Small-For-Size SyndromeBad , Vegfa
Smith-Magenis syndromeErbb2 , Stat3
Spastic Paraplegia Type 7Brca2
spina bifidaGli1
Spina Bifida CysticaActl6a
Spinal Cord InjuriesAkt1 , Brca2 , Cdc42 , Egfr , Met , Rela , Shh , Tgfb1 , Tgfb2 , Tp53 , Vegfa
Spinal Cord Reperfusion InjuryBad
SplenomegalyKras
Spondylocostal Dysostosis 5Mapk3
Sporadic Papillary Renal Cell CarcinomaBraf , Cdkn2a , Erbb2 , Pik3ca , Tp53
squamous cell carcinomaAkt1 , Ccnd1 , Cdkn2a , Egfr , Kras , Mapk1 , Mapk3 , Met , Pik3ca , Stat3 , Tgfb1 , Tp53 , Vegfa
squamous cell neoplasmBrca2
Stargardt diseaseBrca2
Stargardt Disease 1Brca2
status epilepticusBcl2l1 , Ccnd1 , Pgf , Rela , Vegfa
Stevens-Johnson syndromeRb1
stomach cancerErbb2 , Kras , Pik3ca
stomach diseasePten
Stomach NeoplasmsArid1a , Bcl2l1 , Ccnd1 , Cdk4 , Cdkn2a , Egfr , Erbb2 , Gli3 , Kras , Mapk1 , Mapk3 , Mapk8 , Met , Pik3ca , Smad4 , Stat3 , Tgfa , Tp53
StrokeAkt1 , Bcl2l1 , Cdk6 , Mapk8 , Pgf , Pik3ca , Tgfa , Tgfb1 , Vegfa
Subarachnoid HemorrhageGli1 , Shh , Stat3
substance-induced psychosisAkt1
substance-related disorderPten
sudden infant death syndromeVegfa
syndactylyGli3
Syndactyly, Type IVShh
systemic lupus erythematosusJak1 , Pgf
systemic sclerodermaTgfbr1 , Vegfa
T-cell leukemiaCdkn2a , Stat3
T-Cell LymphomaAkt1 , Arid1a , Stat3 , Tp53
Tachycardia, VentricularRaf1
Takenouchi-Kosaki SyndromeCdc42
temporal lobe epilepsyCdc42 , Pgf , Shh , Vegfa
thoracic aortic aneurysmSmad3 , Tgfb2 , Tgfbr1 , Tgfbr2
thoracic diseaseIlk
Thoracic NeoplasmsSmarca4
thrombocytopeniaTgfb1
thrombosisPik3cb
Thrombotic MicroangiopathiesVegfa
thymomaCdkn2a , Pbrm1 , Tp53
Thymus NeoplasmsTp53
thyroid medullary carcinomaKras
Thyroid NeoplasmsAkt1 , Akt2 , Braf , Ccnd1 , Kras , Pik3ca , Pten , Tp53
Tibial FracturesPgf
Tobacco Use DisorderEgfr
Tongue NeoplasmsCdkn2a , Stat3 , Tp53 , Vegfa , Vegfc
tongue squamous cell carcinomaEgfr , Met , Tp53
toxic encephalopathyBcl2l1
tracheal stenosisTgfb1
Tracheoesophageal FistulaBrca2
transient cerebral ischemiaBad , Casp9 , Cdkn2a , Ikbkb , Ilk , Nfkb1 , Pten , Stat3
transitional cell carcinomaAkt1 , Arid1a , Bcl2l1 , Braf , Ccnd1 , Cdk4 , Cdkn2a , Egfr , Erbb2 , Kras , Map2k1 , Mapk1 , Pik3ca , Pten , Smad4 , Tp53
Translocation, GeneticCdkn2a
Transplant RejectionIkbkb , Itga4
Trauma, Nervous SystemStat1
Trigeminal Nerve InjuriesTp53
trigeminal neuralgiaMapk1 , Mapk3 , Mapk8 , Mapk9
trilateral retinoblastomaRb1
TrisomyCdkn2a
Tubulointerstitial FibrosisTgfb1
Tumor Predisposition SyndromeBrca2 , Cdk4 , Cdkn2a , Met , Pten , Smad4 , Tp53
Tympanic Membrane PerforationVegfa
type 1 diabetes mellitusCasp9 , Cdk4 , E2f1 , Egfr , Itga4 , Stat3 , Tgfb1
type 2 diabetes mellitusAkt1 , Akt2 , Bad , Bcl2l1 , Braf , Casp9 , Cdk4 , Egfr , Ikbkb , Mapk1 , Mapk3 , Mapk8 , Mapk9 , Nfkb1 , Pik3cb , Pik3r1 , Rela , Smad4 , Stat3 , Tcf7l2 , Tgfb1 , Tgfbr2 , Vegfa
ulcerative colitisRela , Stat3 , Vegfa
uremiaTgfb1 , Tgfbr1
ureteral obstructionAkt1 , Shh , Tgfb1 , Tgfb2
urethral obstructionMapk1 , Tgfb1
urinary bladder cancerAkt1 , Arid1a , Bcl2l1 , Casp9 , Ccnd1 , Cdk4 , Cdkn2a , E2f1 , Egfr , Erbb2 , Gli1 , Kras , Pten , Ralbp1 , Rb1 , Rela , Smad2 , Smad4 , Tgfbr1 , Tp53 , Vegfa , Vegfc , Vegfd
Urinary Bladder NeoplasmKras , Rb1
Urinary IncontinenceMapk1
Urogenital AbnormalitiesTgfb2
Urogenital NeoplasmsCdkn2a , Tp53
Urologic NeoplasmsCcnd1 , Erbb2 , Tp53 , Vegfa
urticariaTgfb1
Usher syndromeTgfb2
uterine carcinosarcomaErbb2 , Pik3ca , Pik3r1 , Pten , Tp53
Uterine Cervical NeoplasmsAkt1 , Bcl2l1 , Ccnd1 , Cdk4 , Cdkn2a , Egfr , Erbb2 , Kras , Mapk1 , Pik3ca , Pten , Rela , Smad2 , Smad4 , Stat3 , Tp53 , Vegfa
Uterine NeoplasmsBcl2l1 , Braf , Brca2 , Erbb2 , Kras , Map2k1 , Pik3ca , Pik3r1 , Pten , Rac1 , Smad3 , Tp53
uveal melanomaBrca2 , Vegfa
uveitisRela , Tgfb1
VACTERL associationPten , Shh
VACTERL/VATER Association with HydrocephalusPten
varicoceleCasp9
vascular dementiaTp53
Vascular MalformationsPik3ca
vasculogenic impotenceTgfbr2
velocardiofacial syndromeMapk1
Ventilator-Induced Lung InjuryAkt1
Ventricular Dysfunction, LeftRac1
Ventricular Premature ComplexesTgfb3
Ventricular RemodelingSmad2 , Smad3 , Tgfb1
ventricular septal defectBraf , Pgf , Smarca4 , Tgfb3
viral encephalitisE2f1
visual epilepsyArid1b , Bad , Ccnd1 , Pik3ca , Pld1 , Pten
Vitamin D DeficiencyLrp2
vitiligoPik3r1 , Tgfb1
von Hippel-Lindau diseaseCcnd1
Vulvar Lichen SclerosusCdkn2a , Tp53
Vulvar NeoplasmsCdkn2a , Tp53
Wallerian DegenerationErbb2 , Pgf , Tgfb1 , Tgfb2
Weight GainPik3ca
Weissenbacher-Zweymuller syndromeMapk1
Wilson diseaseBrca2
withdrawal disorderMapk1 , Mapk3
Wolff-Parkinson-White syndromeTgfbr2
Woolly Hair, Autosomal RecessiveRb1
Wounds and InjuriesEgf , Tgfb1 , Tgfb2 , Tgfb3 , Vegfa
Wounds, PenetratingPgf
xeroderma pigmentosumTp53
Zollinger-Ellison syndromeEgf
Pathway Annotations Associated with Genes in the pancreatic cancer pathway
Pathway TermsGene Symbols
activin signaling pathwaySmad2 , Smad3
acute myeloid leukemia pathwayAkt1 , Akt2 , Akt3 , Bad , Braf , Ccnd1 , Chuk , Ikbkb , Ikbkg , Kras , Map2k1 , Mapk1 , Mapk3 , Nfkb1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Raf1 , Rela , Stat3 , Tcf7l2
adenosine signaling pathwayAkt1 , Bad , Braf , Cdc42 , Chuk , Ikbkb , Mapk1 , Mapk8 , Nfkb1 , Pik3ca
aldosterone signaling pathwayKras , Mapk1 , Mapk3 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5
altered epidermal growth factor/neuregulin signaling pathwayEgf , Egfr , Erbb2 , Tgfa
altered extracellular signal-regulated Raf/Mek/Erk signaling pathwayBraf , Kras , Map2k1 , Raf1
altered G1/S transition pathwayCdkn2a
altered Hedgehog signaling pathwayBoc , Gli1 , Gli3 , Lrp2 , Shh
altered insulin responsive facilitative sugar transporter mediated glucose transport pathwayAkt2
altered integrin mediated signaling pathwayIlk , Itga11 , Itga4 , Itga9
altered p53 signaling pathwayTp53
altered phosphatidylinositol 3-kinase signaling pathwayPik3ca , Pten
altered phosphatidylinositol 3-kinase-Akt signaling pathwayAkt1 , Akt2 , Akt3 , Pik3ca , Pten
altered scatter factor/hepatocyte growth factor signaling pathwayMet
altered SWI/SNF family mediated chromatin remodeling pathwayActl6a , Arid1a , Arid1b , Pbrm1 , Smarca4
altered transforming growth factor-beta Smad dependent signaling pathwaySmad2 , Smad3 , Smad4 , Tgfb1 , Tgfbr1 , Tgfbr2
altered vascular endothelial growth factor signaling pathway involving proteins affecting its expressionVegfa
altered vascular endothelial growth factor signaling pathway involving the main playersVegfa
altered Wnt signaling, canonical pathwayTcf7l2 , Wnt9a
Alzheimer's disease pathwayBad , Casp9 , Mapk1 , Mapk3
amyotrophic lateral sclerosis pathwayBad , Bcl2l1 , Casp9 , Rac1 , Tp53
apoptotic cell death pathwayAkt1 , Akt2 , Akt3 , Bad , Bcl2l1 , Casp9 , Chuk , Ikbkb , Ikbkg , Nfkb1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Rela , Tp53
Arf family mediated signaling pathwayRac1
arrhythmogenic right ventricular cardiomyopathy pathwayItga11 , Itga4 , Itga9 , Tcf7l2
azathioprine pharmacodynamics pathwayRac1
B cell receptor signaling pathwayAkt1 , Akt2 , Akt3 , Chuk , Ikbkb , Ikbkg , Kras , Map2k1 , Mapk1 , Mapk3 , Nfkb1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Rac1 , Rac2 , Raf1 , Rela
basal cell carcinoma pathwayGli1 , Gli3 , Shh , Tcf7l2 , Tp53 , Wnt9a
bevacizumab pharmacodynamics pathwayVegfa
Bone morphogenetic proteins signaling pathwayMapk1 , Smad4
c-Jun N-terminal kinases MAPK signaling pathwayCdc42 , Mapk10 , Mapk8 , Mapk9 , Rac1
calcium/calcium-mediated signaling pathwayEgfr , Erbb2
cell cycle pathway, mitoticCcnd1 , Cdk4 , Cdk6 , Cdkn2a , E2f1 , E2f3 , Rb1 , Smad2 , Smad3 , Smad4 , Tgfb1 , Tgfb2 , Tgfb3 , Tp53
cell-extracellular matrix signaling pathwayItga11 , Itga4 , Itga9
ceramide signaling pathwayAkt1 , Akt2 , Akt3 , Arhgef6 , Bad , Bcl2l1 , Braf , Brca2 , Casp9 , Ccnd1 , Cdc42 , Cdk4 , Cdk6 , Cdkn2a , Chuk , E2f1 , E2f3 , Egf , Egfr , Erbb2 , Ikbkb , Ikbkg , Jak1 , Kras , Map2k1 , Mapk1 , Mapk10 , Mapk3 , Mapk8 , Mapk9 , Nfkb1 , Pgf , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Pld1 , Rac1 , Rac2 , Rad51 , Raf1 , Rala , Ralb , Ralbp1 , Ralgds , Rb1 , Rela , Smad2 , Smad3 , Smad4 , Stat1 , Stat3 , Tgfa , Tgfb1 , Tgfb2 , Tgfb3 , Tgfbr1 , Tgfbr2 , Tp53 , Vegfa , Vegfb , Vegfc , Vegfd
cetuximab pharmacodynamics pathwayEgfr
Chagas disease pathwayAkt1 , Akt2 , Akt3 , Chuk , Ikbkb , Ikbkg , Mapk1 , Mapk10 , Mapk3 , Mapk8 , Mapk9 , Nfkb1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Rela , Smad2 , Smad3 , Tgfb1 , Tgfb2 , Tgfb3 , Tgfbr1 , Tgfbr2
chemokine mediated signaling pathwayAkt1 , Akt2 , Akt3 , Braf , Cdc42 , Chuk , Ikbkb , Ikbkg , Kras , Map2k1 , Mapk1 , Mapk3 , Nfkb1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Rac1 , Rac2 , Raf1 , Rela , Stat1 , Stat3
chronic myeloid leukemia pathwayAkt1 , Akt2 , Akt3 , Bad , Bcl2l1 , Braf , Ccnd1 , Cdk4 , Cdk6 , Cdkn2a , Chuk , E2f1 , E2f3 , Ikbkb , Ikbkg , Kras , Map2k1 , Mapk1 , Mapk3 , Nfkb1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Raf1 , Rb1 , Rela , Smad3 , Smad4 , Tgfb1 , Tgfb2 , Tgfb3 , Tgfbr1 , Tgfbr2 , Tp53
colorectal cancer pathwayAkt1 , Akt2 , Akt3 , Bad , Braf , Casp9 , Ccnd1 , Kras , Map2k1 , Mapk1 , Mapk10 , Mapk3 , Mapk8 , Mapk9 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Rac1 , Rac2 , Raf1 , Ralgds , Smad2 , Smad3 , Smad4 , Tcf7l2 , Tgfb1 , Tgfb2 , Tgfb3 , Tgfbr1 , Tgfbr2 , Tp53
cortisol signaling pathwaySmarca4
cytokine mediated signaling pathwayEgf , Egfr , Met , Tgfb1 , Tgfb2 , Tgfb3 , Tgfbr1 , Tgfbr2 , Vegfc , Vegfd
dilated cardiomyopathy pathwayItga11 , Itga4 , Itga9 , Tgfb1 , Tgfb2 , Tgfb3
doxorubicin pharmacokinetics pathwayRalbp1
E-cadherin signaling pathwayAkt1 , Akt2 , Ccnd1 , Cdc42 , Egf , Egfr , Pik3ca , Pik3r1 , Rac1
eicosanoid signaling pathwayAkt1 , Egf , Egfr , Pik3r5 , Rac1
eicosanoid signaling pathway via peroxisome proliferator-activated receptor gammaIlk
endocytosis pathwayCdc42 , Egf , Egfr , Met , Pld1 , Smad2 , Smad3 , Tgfb1 , Tgfb2 , Tgfb3 , Tgfbr1 , Tgfbr2
endometrial cancer pathwayAkt1 , Akt2 , Akt3 , Bad , Braf , Casp9 , Ccnd1 , Egf , Egfr , Erbb2 , Ilk , Kras , Map2k1 , Mapk1 , Mapk3 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Pten , Raf1 , Tcf7l2 , Tp53
Endoplasmic Reticulum-associated degradation pathwayMapk10 , Mapk8 , Mapk9
endothelin signaling pathwayAkt1 , Cdc42 , Map2k1 , Mapk1 , Mapk3 , Mapk8 , Rac1 , Raf1
Entamoebiasis pathwayNfkb1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Rela , Tgfb1 , Tgfb2 , Tgfb3
ephrin - ephrin receptor bidirectional signaling axisCdc42 , Map2k1 , Mapk1 , Mapk3 , Mapk8 , Pik3ca , Pik3r1 , Pik3r5 , Rac1
epidermal growth factor/neuregulin signaling pathwayAkt1 , Akt2 , Akt3 , Bad , Braf , Egf , Egfr , Erbb2 , Kras , Map2k1 , Mapk1 , Mapk10 , Mapk3 , Mapk8 , Mapk9 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Raf1 , Stat1 , Stat3 , Tgfa
erlotinib pharmacodynamics pathwayEgfr
erythropoietin signaling pathwayBcl2l1 , Mapk8 , Nfkb1 , Pik3r1 , Stat1
ether lipid metabolic pathwayPld1
ether lipid metabolic pathwayPld1
FasL mediated signaling pathwayAkt1 , Chuk , Ikbkb , Ikbkg , Mapk10 , Mapk8 , Mapk9 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3
Fc epsilon receptor mediated signaling pathwayAkt1 , Akt2 , Akt3 , Kras , Map2k1 , Mapk1 , Mapk10 , Mapk3 , Mapk8 , Mapk9 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Rac1 , Rac2 , Raf1
Fc gamma receptor mediated signaling pathwayAkt1 , Akt2 , Akt3 , Cdc42 , Map2k1 , Mapk1 , Mapk3 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Pld1 , Rac1 , Rac2 , Raf1
fibroblast growth factor signaling pathwayAkt1 , Mapk1 , Mapk3 , Pik3ca , Pik3r1 , Stat1
forkhead class A signaling pathwayAkt1 , Shh
G1 phase pathwayCcnd1 , Cdk4
G1/S transition pathwayCcnd1 , Cdk4 , Cdk6 , Cdkn2a , Rb1
gefitinib pharmacodynamics pathwayEgfr
glioma pathwayAkt1 , Akt2 , Akt3 , Braf , Ccnd1 , Cdk4 , Cdk6 , Cdkn2a , E2f1 , E2f3 , Egf , Egfr , Kras , Map2k1 , Mapk1 , Mapk3 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Pten , Raf1 , Rb1 , Tgfa , Tp53
glutamate signaling pathwayMapk1 , Mapk3 , Pld1
glycerophospholipid metabolic pathwayPld1
glypican signaling pathwayMapk8 , Mapk9 , Shh , Smad2 , Tgfb1 , Tgfb2 , Tgfb3 , Tgfbr2 , Vegfa
gonadotropin-releasing hormone signaling pathwayCdc42 , Egfr , Kras , Map2k1 , Mapk1 , Mapk10 , Mapk3 , Mapk8 , Mapk9 , Pld1 , Raf1
granulocyte-macrophage colony-stimulating factor signaling pathwayIkbkb , Map2k1 , Mapk1 , Mapk3 , Pik3ca , Pik3r1 , Raf1 , Stat1 , Stat3
Hedgehog signaling pathwayAkt1 , Boc , Gli1 , Gli3 , Lrp2 , Map2k1 , Pik3ca , Pik3r1 , Shh , Tgfb2 , Wnt9a
hepatitis C pathwayAkt1 , Akt2 , Akt3 , Bad , Braf , Chuk , Egf , Egfr , Ikbkb , Ikbkg , Jak1 , Kras , Mapk1 , Mapk10 , Mapk3 , Mapk8 , Mapk9 , Nfkb1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Raf1 , Rela , Stat1 , Stat3 , Tp53
histone modification pathwayPbrm1 , Smarca4
homologous recombination pathway of double-strand break repairBrca2 , Rad51
Huntington's disease pathwayCasp9 , Tp53
hypertrophic cardiomyopathy pathwayItga11 , Itga4 , Itga9 , Tgfb1 , Tgfb2 , Tgfb3
hypoxia inducible factor pathwayAkt1 , Smad3 , Smad4 , Vegfa
inflammatory response pathwayMapk8
influenza A pathwayAkt1 , Akt2 , Akt3 , Casp9 , Ikbkb , Jak1 , Map2k1 , Mapk1 , Mapk10 , Mapk3 , Mapk8 , Mapk9 , Nfkb1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Raf1 , Rela , Stat1
INO80 family mediated chromatin remodeling pathwayActl6a
inositol metabolic pathwayPik3ca
inositol phosphate metabolic pathwayPik3ca , Pik3cb , Pik3cd , Pten
insulin responsive facilitative sugar transporter mediated glucose transport pathwayAkt1 , Akt2 , Rac1
insulin secretion pathwayCdc42
insulin signaling pathwayAkt1 , Akt2 , Akt3 , Bad , Braf , Ikbkb , Kras , Map2k1 , Mapk1 , Mapk10 , Mapk3 , Mapk8 , Mapk9 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Raf1
insulin-like growth factor signaling pathwayAkt1 , Bad , Pik3ca , Pik3r1 , Raf1
integrin mediated signaling pathwayIlk , Itga11 , Itga4 , Itga9
interleukin-1 signaling pathwayChuk , Ikbkb , Ikbkg , Mapk8 , Nfkb1 , Pik3ca , Pik3r1 , Rela
Interleukin-10 signaling pathwayJak1 , Stat1 , Stat3
interleukin-12 signaling pathwayNfkb1 , Rela , Stat1 , Stat3
interleukin-2 signaling pathwayJak1 , Map2k1 , Mapk1 , Mapk3 , Mapk8 , Mapk9 , Pik3ca , Pik3r1 , Raf1 , Stat1 , Stat3
interleukin-23 signaling pathwayNfkb1 , Pik3ca , Pik3r1 , Rela , Stat1 , Stat3
interleukin-27 signaling pathwayJak1 , Stat1 , Stat3 , Tgfb1
interleukin-3 signaling pathwayBcl2l1 , Pik3ca , Pik3r1
interleukin-4 signaling pathwayAkt1 , Jak1 , Pik3ca , Pik3r1
interleukin-5 signaling pathwayPik3ca , Pik3r1
interleukin-6 signaling pathwayAkt1 , Jak1 , Pik3ca , Pik3r1 , Rac1 , Stat1 , Stat3
intrinsic apoptotic pathwayBad , Bcl2l1 , Casp9
Jak-Stat signaling pathwayAkt1 , Akt2 , Akt3 , Bcl2l1 , Ccnd1 , Jak1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Stat1 , Stat3
Leishmaniasis pathwayItga4 , Jak1 , Mapk1 , Mapk3 , Nfkb1 , Rela , Stat1 , Tgfb1 , Tgfb2 , Tgfb3
leptin system pathwayStat3
long term depressionBraf , Kras , Map2k1 , Mapk1 , Mapk3 , Raf1
long term potentiationBraf , Kras , Map2k1 , Mapk1 , Mapk3 , Raf1
malaria pathwayMet , Tgfb1 , Tgfb2 , Tgfb3
measles pathwayAkt1 , Akt2 , Akt3 , Ccnd1 , Cdk4 , Cdk6 , Chuk , Jak1 , Nfkb1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Rela , Stat1 , Stat3 , Tp53
melanoma pathwayAkt1 , Akt2 , Akt3 , Bad , Braf , Ccnd1 , Cdk4 , Cdk6 , Cdkn2a , E2f1 , E2f3 , Egf , Egfr , Kras , Map2k1 , Mapk1 , Mapk3 , Met , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Pten , Raf1 , Rb1 , Tp53
mercaptopurine pharmacodynamics pathwayRac1
mercaptopurine pharmacokinetics pathwayRac1
mitogen activated protein kinase signaling pathwayAkt1 , Akt2 , Akt3 , Braf , Cdc42 , Chuk , Egf , Egfr , Erbb2 , Ikbkb , Ikbkg , Kras , Map2k1 , Mapk1 , Mapk10 , Mapk3 , Mapk8 , Mapk9 , Nfkb1 , Rac1 , Rac2 , Raf1 , Rela , Tgfb1 , Tgfb2 , Tgfb3 , Tgfbr1 , Tgfbr2 , Tp53
mTOR signaling pathwayAkt1 , Akt2 , Akt3 , Braf , Ikbkb , Map2k1 , Mapk1 , Mapk3 , Pgf , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Pld1 , Rac1 , Raf1 , Vegfa , Vegfb , Vegfc , Vegfd
myocarditis pathwayCasp9 , Ccnd1 , Rac1 , Rac2
N-cadherin signaling pathwayCdc42 , Mapk8 , Pik3ca , Pik3r1 , Rac1
neurotrophic factor signaling pathwayAkt1 , Akt2 , Akt3 , Bad , Braf , Cdc42 , Ikbkb , Kras , Map2k1 , Mapk1 , Mapk10 , Mapk3 , Mapk8 , Mapk9 , Nfkb1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Rac1 , Raf1 , Rela , Tp53
NOD-like receptor signaling pathwayChuk , Ikbkb , Ikbkg , Mapk1 , Mapk10 , Mapk3 , Mapk8 , Mapk9 , Nfkb1 , Rela
non-small cell lung carcinoma pathwayAkt1 , Akt2 , Akt3 , Bad , Braf , Casp9 , Ccnd1 , Cdk4 , Cdk6 , Cdkn2a , E2f1 , E2f3 , Egf , Egfr , Erbb2 , Kras , Map2k1 , Mapk1 , Mapk3 , Met , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Pten , Raf1 , Rb1 , Tgfa , Tp53
Non-Stat, Jak dependent pathwayJak1
Notch signaling pathwayCcnd1
nuclear factor kappa B signaling pathwayChuk , Ikbkb , Ikbkg , Nfkb1 , Pik3ca , Pik3r1 , Rela
nuclear factor, erythroid 2 like 2 signaling pathwayIkbkb , Pten
p38 MAPK signaling pathwayCdc42 , Rac1
p53 signaling pathwayAkt1 , Casp9 , Ccnd1 , Cdk4 , Cdk6 , Cdkn2a , Mapk8 , Mapk9 , Pten , Tp53
p53-dependent G1/S DNA damage checkpoint pathwayTp53
pancreatic cancer pathwayActl6a , Akt1 , Akt2 , Akt3 , Arhgef6 , Arid1a , Arid1b , Bad , Bcl2l1 , Boc , Braf , Brca2 , Casp9 , Ccnd1 , Cdc42 , Cdk4 , Cdk6 , Cdkn2a , Chuk , E2f1 , E2f3 , Egf , Egfr , Erbb2 , Gli1 , Gli3 , Ikbkb , Ikbkg , Ilk , Itga11 , Itga4 , Itga9 , Jak1 , Kras , Lrp2 , Map2k1 , Mapk1 , Mapk10 , Mapk3 , Mapk8 , Mapk9 , Met , Nfkb1 , Pbrm1 , Pgf , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Pld1 , Pten , Rac1 , Rac2 , Rad51 , Raf1 , Rala , Ralb , Ralbp1 , Ralgds , Rb1 , Rela , Shh , Smad2 , Smad3 , Smad4 , Smarca4 , Stat1 , Stat3 , Tcf7l2 , Tgfa , Tgfb1 , Tgfb2 , Tgfb3 , Tgfbr1 , Tgfbr2 , Tp53 , Vegfa , Vegfb , Vegfc , Vegfd , Wnt9a
panitumumab pharmacodynamics pathwayEgfr
Parkinson's disease pathwayCasp9
phagocytosis pathwayRac1
phosphatidylinositol 3-kinase class I signaling pathwayPik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Pten , Rac1
phosphatidylinositol 3-kinase signaling pathwayPik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Pten
phosphatidylinositol 3-kinase-Akt signaling pathwayAkt1 , Akt2 , Akt3 , Bad , Casp9 , Chuk , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pten , Raf1
phosphoinositide metabolic pathwayEgfr , Erbb2 , Pik3ca , Pik3cd , Pik3r1 , Pten
platelet-derived growth factor signaling pathwayBraf , Jak1 , Map2k1 , Mapk1 , Mapk10 , Mapk3 , Mapk8 , Mapk9 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Pten , Rac1 , Raf1 , Stat1 , Stat3
primary immunodeficiency pathwayIkbkg
prion disease pathwayMap2k1 , Mapk1 , Mapk3
prostate cancer pathwayAkt1 , Akt2 , Akt3 , Bad , Braf , Casp9 , Ccnd1 , Chuk , E2f1 , E2f3 , Egf , Egfr , Erbb2 , Ikbkb , Ikbkg , Kras , Map2k1 , Mapk1 , Mapk3 , Nfkb1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Pten , Raf1 , Rb1 , Rela , Tcf7l2 , Tgfa , Tp53
Ras mediated signaling pathwayErbb2
Reelin signaling pathwayAkt1 , Mapk8 , Pik3ca , Pik3r1
renal cell carcinoma pathwayAkt1 , Akt2 , Akt3 , Braf , Cdc42 , Kras , Map2k1 , Mapk1 , Mapk3 , Met , Pbrm1 , Pgf , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Rac1 , Raf1 , Tgfa , Tgfb1 , Tgfb2 , Tgfb3 , Vegfa , Vegfb , Vegfc , Vegfd
Retinoic acid-inducible gene (RIG) I-like receptor signaling pathwayChuk , Ikbkb , Ikbkg , Mapk10 , Mapk8 , Mapk9 , Nfkb1 , Rela
rheumatoid arthritis pathwayPgf , Tgfb1 , Tgfb2 , Tgfb3 , Vegfa , Vegfb
Rho/Rac/Cdc42 mediated signaling pathwayCdc42 , Mapk8 , Rac1
RNA polymerase III transcription pathwayRb1
S phase pathwayCcnd1 , Cdk4
scatter factor/hepatocyte growth factor signaling pathwayMet , Pik3r1
small cell lung carcinoma pathwayAkt1 , Akt2 , Akt3 , Bcl2l1 , Casp9 , Ccnd1 , Cdk4 , Cdk6 , Chuk , E2f1 , E2f3 , Ikbkb , Ikbkg , Nfkb1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Pten , Rb1 , Rela , Tp53
sphingosine 1-phosphate signaling pathwayAkt1 , Akt3 , Cdc42 , Mapk1 , Mapk3 , Mapk8 , Rac1 , Vegfa
SWI/SNF family mediated chromatin remodeling pathwayActl6a , Arid1a , Arid1b , Pbrm1 , Smarca4
syndecan signaling pathwayEgfr , Mapk1 , Mapk3 , Mapk8 , Rac1 , Tgfb1
T cell receptor signaling pathwayAkt1 , Akt2 , Akt3 , Cdc42 , Cdk4 , Chuk , Ikbkb , Ikbkg , Kras , Map2k1 , Mapk1 , Mapk3 , Mapk9 , Nfkb1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Raf1 , Rela
the extracellular signal-regulated Raf/Mek/Erk signaling pathwayBraf , Kras , Map2k1 , Mapk1 , Mapk3 , Raf1
thyroid cancer pathwayBraf , Ccnd1 , Kras , Map2k1 , Mapk1 , Mapk3 , Tcf7l2 , Tp53
tioguanine pharmacodynamics pathwayRac1
titanium dioxide nanoparticle response pathwayTp53
Toll-like receptor signaling pathwayAkt1 , Akt2 , Akt3 , Chuk , Ikbkb , Ikbkg , Map2k1 , Mapk1 , Mapk10 , Mapk3 , Mapk8 , Mapk9 , Nfkb1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Rac1 , Rela , Stat1
toxoplasmosis pathwayAkt1 , Akt2 , Akt3 , Bad , Bcl2l1 , Casp9 , Chuk , Ikbkb , Ikbkg , Jak1 , Mapk1 , Mapk10 , Mapk3 , Mapk8 , Mapk9 , Nfkb1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Rela , Stat1 , Stat3 , Tgfb1 , Tgfb2 , Tgfb3
Trail mediated signaling pathwayChuk , Ikbkb , Ikbkg , Mapk1 , Mapk3 , Mapk8 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3
transforming growth factor-beta Smad dependent signaling pathwaySmad2 , Smad3 , Smad4 , Tgfb1 , Tgfb2 , Tgfb3 , Tgfbr1 , Tgfbr2
transforming growth factor-beta superfamily mediated signaling pathwayMapk1 , Mapk3 , Smad2 , Smad3 , Smad4 , Tgfb1 , Tgfb2 , Tgfb3 , Tgfbr1 , Tgfbr2
trastuzumab pharmacodynamics pathwayEgfr
tuberculosis pathwayAkt1 , Akt2 , Akt3 , Bad , Casp9 , Jak1 , Mapk1 , Mapk10 , Mapk3 , Mapk8 , Mapk9 , Nfkb1 , Raf1 , Rela , Stat1 , Tgfb1 , Tgfb2 , Tgfb3
tumor necrosis factor mediated signaling pathwayChuk , Ikbkb , Ikbkg , Nfkb1 , Rela , Stat1
type 2 diabetes mellitus pathwayAkt2 , Ikbkb , Mapk1 , Mapk10 , Mapk3 , Mapk8 , Mapk9 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5
type II interferon signaling pathwayAkt1 , Jak1 , Map2k1 , Mapk1 , Mapk3 , Pik3ca , Pik3r1 , Stat1 , Stat3
urinary bladder cancer pathwayBraf , Ccnd1 , Cdk4 , Cdkn2a , E2f1 , E2f3 , Egf , Egfr , Erbb2 , Kras , Map2k1 , Mapk1 , Mapk3 , Pgf , Raf1 , Rb1 , Tp53 , Vegfa , Vegfb , Vegfc , Vegfd
vascular endothelial growth factor signaling pathwayAkt1 , Akt2 , Akt3 , Bad , Braf , Casp9 , Cdc42 , Kras , Map2k1 , Mapk1 , Mapk3 , Pgf , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Rac1 , Rac2 , Raf1 , Vegfa , Vegfb , Vegfc , Vegfd
vinblastine pharmacodynamics pathwayRalbp1 , Tp53
vincristine pharmacodynamics pathwayRalbp1 , Tp53
vindesine pharmacodynamics pathwayRalbp1 , Tp53
vinorelbine pharmacodynamics pathwayRalbp1 , Tp53
Wnt signaling pathwayCcnd1 , Mapk10 , Mapk8 , Mapk9 , Rac1 , Rac2 , Smad2 , Smad3 , Smad4 , Tcf7l2 , Tp53 , Wnt9a
Wnt signaling, canonical pathwaySmarca4 , Tcf7l2 , Wnt9a
Wnt signaling, non-canonical pathwayCdc42 , Mapk10 , Mapk8 , Mapk9 , Rac1
Wnt signaling, the planar cell polarity pathwayRac1
Phenotype Annotations Associated with Genes in the pancreatic cancer pathway

References Associated with the pancreatic cancer pathway:

Ontology Path Diagram:

paths to the root

Import into Pathway Studio: