RGD Reference Report - Upregulation of interleukin-1beta/transforming growth factor-beta1 and hypoxia relate to molecular mechanisms underlying immobilization-induced muscle contracture. - Rat Genome Database

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Upregulation of interleukin-1beta/transforming growth factor-beta1 and hypoxia relate to molecular mechanisms underlying immobilization-induced muscle contracture.

Authors: Honda, Y  Sakamoto, J  Nakano, J  Kataoka, H  Sasabe, R  Goto, K  Tanaka, M  Origuchi, T  Yoshimura, T  Okita, M 
Citation: Honda Y, etal., Muscle Nerve. 2015 Sep;52(3):419-27. doi: 10.1002/mus.24558. Epub 2015 Jun 30.
RGD ID: 11073672
Pubmed: PMID:25641164   (View Abstract at PubMed)
DOI: DOI:10.1002/mus.24558   (Journal Full-text)

INTRODUCTION: In this study we investigated the molecular mechanism underlying muscle contracture in rats. METHODS: The rats were divided into immobilization and control groups, and soleus muscles of the right and left sides were selected for analyses. RESULTS: The levels of CD11b and alpha-SMA protein, IL-1beta, and TGF-beta1 mRNA, and type I and III collagen protein and mRNA were significantly greater in the immobilization group than in the control group at all time-points. HIF-1alpha mRNA levels were significantly higher in the immobilization group at 4 weeks. Moreover, HIF-1alpha, alpha-SMA, and type I collagen levels were significantly higher at 4 weeks than at 1 and 2 weeks in the immobilization group. CONCLUSIONS: In the early stages of immobilization, upregulation of IL-1beta/TGF-beta1 via macrophages may promote fibroblast differentiation that could affect muscle contracture. The soleus muscle became hypoxic in the later stages of immobilization, suggesting that hypoxia influences the progression of muscle contracture.



Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Il1bRatresponse to immobilization stress  IEP  RGD 
Tgfb1Ratresponse to immobilization stress  IEP  RGD 

Objects Annotated

Genes (Rattus norvegicus)
Il1b  (interleukin 1 beta)
Tgfb1  (transforming growth factor, beta 1)


Additional Information