GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Tgfb1 | increases expression | ISO | Tgfb1 (Mus musculus) | 39939031 | RGD | lipopolysaccharide increases expression of tgfb1 in splenic conventional dendritic cells | | Tgfb1 | increases expression | EXP | | 6480464 | CTD | Lipopolysaccharides results in increased expression of TGFB1 mRNA; Lipopolysaccharides results in increased expression of TGFB1 protein | PMID:19118600 PMID:28693884 PMID:29480285 PMID:37148149 | Tgfb1 | multiple interactions | EXP | | 6480464 | CTD | 2,2-bis(4-glycidyloxyphenyl)propane inhibits the reaction [Curcumin inhibits the reaction [Lipopolysaccharides results in increased expression of TGFB1 protein]]; [Lipopolysaccharides co-treated with Aminoimidazole Carboxamide analog] results in increased expression of TGFB1 protein; [Lipopolysaccharides co-treated with Glucose] results in increased secretion of TGFB1 protein; AGTR2 protein promotes the reaction [Lipopolysaccharides results in increased expression of TGFB1 mRNA]; Calcitriol inhibits the reaction [[Lipopolysaccharides co-treated with Glucose] results in increased secretion of TGFB1 protein]; Curcumin inhibits the reaction [Lipopolysaccharides results in increased expression of TGFB1 protein]; gossypin inhibits the reaction [Lipopolysaccharides results in increased expression of TGFB1 protein]; Lipopolysaccharides inhibits the reaction [Thioacetamide results in increased expression of TGFB1 mRNA]; Rutin inhibits the reaction [Lipopolysaccharides results in increased expression of TGFB1 mRNA] | PMID:17621560 PMID:19118600 PMID:19853624 PMID:21788014 PMID:28693884 PMID:29480285 PMID:37148149 | Tgfb1 | decreases expression | ISO | TGFB1 (Homo sapiens) | 6480464 | CTD | Lipopolysaccharides results in decreased expression of TGFB1 mRNA | PMID:25725100 PMID:32917723 | Tgfb1 | increases expression | ISO | TGFB1 (Homo sapiens) | 6480464 | CTD | Lipopolysaccharides results in increased expression of TGFB1 mRNA; Lipopolysaccharides results in increased expression of TGFB1 protein | PMID:11344824 PMID:21147091 PMID:35781746 | Tgfb1 | increases expression | ISO | Tgfb1 (Mus musculus) | 6480464 | CTD | Lipopolysaccharides results in increased expression of TGFB1 mRNA; Lipopolysaccharides results in increased expression of TGFB1 protein | PMID:14644621 PMID:21396992 PMID:25896969 PMID:27461142 PMID:32339640 | Tgfb1 | increases secretion | ISO | TGFB1 (Homo sapiens) | 6480464 | CTD | Lipopolysaccharides results in increased secretion of TGFB1 protein | PMID:34740670 PMID:8968517 | Tgfb1 | multiple interactions | ISO | TGFB1 (Homo sapiens) | 6480464 | CTD | (+)-JQ1 compound inhibits the reaction [Lipopolysaccharides results in decreased expression of TGFB1 mRNA]; [IFNG protein, human co-treated with Lipopolysaccharides] results in decreased expression of TGFB1 mRNA; [IFNG protein, human co-treated with Lipopolysaccharides] results in decreased secretion of TGFB1 protein; [Particulate Matter co-treated with Lipopolysaccharides] results in decreased expression of TGFB1 protein; [Uric Acid co-treated with TGFB1 protein] promotes the reaction [Lipopolysaccharides results in increased secretion of IL1B protein]; [Uric Acid co-treated with TGFB1 protein] promotes the reaction [Lipopolysaccharides results in increased secretion of IL6 protein]; [Vehicle Emissions co-treated with Lipopolysaccharides] results in decreased expression of TGFB1 protein; Cannabidiol inhibits the reaction [Lipopolysaccharides results in increased secretion of TGFB1 protein]; Chromium inhibits the reaction [Lipopolysaccharides results in increased secretion of TGFB1 protein]; Cobalt inhibits the reaction [Lipopolysaccharides results in increased secretion of TGFB1 protein]; honokiol inhibits the reaction [Lipopolysaccharides results in increased expression of TGFB1 protein]; Lipopolysaccharides promotes the reaction [TGFB1 protein results in increased expression of MIR942 mRNA]; Lipopolysaccharides promotes the reaction [TGFB1 results in increased expression of PDGFB mRNA]; Lipopolysaccharides promotes the reaction [TGFB1 results in increased expression of PDGFB protein]; MAPK9 gene mutant form inhibits the reaction [Lipopolysaccharides promotes the reaction [TGFB1 results in increased expression of PDGFB mRNA]]; NFKBIA protein mutant form inhibits the reaction [Lipopolysaccharides promotes the reaction [TGFB1 results in increased expression of PDGFB mRNA]]; TGFB1 protein promotes the reaction [Lipopolysaccharides results in increased expression of MIR942 mRNA]; Titanium inhibits the reaction [Lipopolysaccharides results in increased secretion of TGFB1 protein] | PMID:11737050 PMID:21147091 PMID:22004089 PMID:25725100 PMID:30097701 PMID:34740670 PMID:36277599 PMID:36850003 PMID:8968517 | Tgfb1 | multiple interactions | ISO | Tgfb1 (Mus musculus) | 6480464 | CTD | [[Lipopolysaccharides binds to and results in increased activity of TLR4 protein] which co-treated with Tetrachlorodibenzodioxin] results in increased expression of TGFB1 mRNA; [Industrial Waste co-treated with Lipopolysaccharides] results in increased expression of TGFB1 mRNA; [Inorganic Chemicals co-treated with Lipopolysaccharides] results in increased expression of TGFB1 mRNA; [Lipopolysaccharides co-treated with IFNG protein] results in increased expression of TGFB1 mRNA; [Lipopolysaccharides co-treated with indole-3-carbinol] results in decreased expression of TGFB1 mRNA; [Lipopolysaccharides results in increased phosphorylation of SMAD3 protein] promotes the reaction [Lipopolysaccharides inhibits the reaction [TGFB1 protein results in increased expression of SMAD6 mRNA]]; Clopidogrel inhibits the reaction [Lipopolysaccharides results in increased expression of TGFB1 mRNA]; deoxynivalenol promotes the reaction [Lipopolysaccharides results in increased expression of TGFB1 mRNA]; IRAK1 protein promotes the reaction [Lipopolysaccharides inhibits the reaction [TGFB1 protein results in increased expression of SMAD6 mRNA]]; Lipopolysaccharides inhibits the reaction [TGFB1 protein results in increased activity of SMAD3 protein]; Lipopolysaccharides inhibits the reaction [TGFB1 protein results in increased expression of SMAD6 mRNA]; mangiferin promotes the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of TGFB1 mRNA]; MAP2K1 protein promotes the reaction [Lipopolysaccharides inhibits the reaction [TGFB1 protein results in increased expression of SMAD6 mRNA]]; MAPK1 protein promotes the reaction [Lipopolysaccharides inhibits the reaction [TGFB1 protein results in increased expression of SMAD6 mRNA]]; MAPK3 protein promotes the reaction [Lipopolysaccharides inhibits the reaction [TGFB1 protein results in increased expression of SMAD6 mRNA]]; SMAD3 protein modified form promotes the reaction [Lipopolysaccharides inhibits the reaction [TGFB1 protein results in increased expression of SMAD6 mRNA]]; TGFB1 protein inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]; TGFB1 protein inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]; TLR4 protein promotes the reaction [Lipopolysaccharides inhibits the reaction [TGFB1 protein results in increased expression of SMAD6 mRNA]]; U 0126 inhibits the reaction [Lipopolysaccharides inhibits the reaction [TGFB1 protein results in increased expression of SMAD6 mRNA]] | PMID:12694877 PMID:14644621 PMID:19172522 PMID:21097750 PMID:21295571 PMID:21948866 PMID:32339640 | | ||||||||||||||||||||||
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