RGD Reference Report - [Relationship between transforming growth factor-β1 and interleukin-10 single nucleotide polymorphism and susceptibility of recurrent aphthous ulcer]. - Rat Genome Database

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[Relationship between transforming growth factor-β1 and interleukin-10 single nucleotide polymorphism and susceptibility of recurrent aphthous ulcer].

Authors: Jing, Zhang  Jingjing, Sha  Juan, Gong 
Citation: Jing Z, etal., Hua Xi Kou Qiang Yi Xue Za Zhi. 2016 Feb;34(1):27-31.
RGD ID: 14975145
Pubmed: (View Article at PubMed) PMID:27266194


OBJECTIVE: To explore the possible relationship between recurrent aphthous ulcer (RAU) and single nucleotide polymorphism (SNP) of transforming growth factor-β1 (TGF-β1)-509T/C and interleukin-10 (IL-10)-1082A/G sites.
METHODS: A total of 138 RAU patients were recruited for this study. The control group consisted of 124 subjects. TGF-β1-509T/C and IL-10-1082A/G sites were detected by restriction fragment length polymorphism-polymerase chain reaction (RFLP-PCR) and sequence specific primer-polymerase chain reaction (SSP-PCR). Relative risk ratios were estimated by odds ratios (OR) and 95% confidence interval (95%CI).
RESULTS: Significant differences were found in the genotype frequencies or allele frequencies of TGF-β1-509T/C and IL-10-1082A/G sites between the RAU patients and controls (P < 0.05). CT genotype (OR = 1.231, 95% CI = 0.702-2.160), TT genotype (OR = 2.482, 95% CI = 1.250-4.927), and T allele (OR = 1.465, 95% CI = 1.036-2.074) at the TGF-β1-509 site exhibited high risks. AG genotype (OR = 1.391, 95% CI = 0.808-2.396), GG genotype (OR = 4.165, 95% CI = 1.944-8.924), and G allele (OR = 2.134, 95% CI = 1.474-3.089) at the IL-10-1082A/G site also showed high risks.
CONCLUSION: TGF-β1-509T/C and IL-10-1082A/G sites are associated with the risk of RAU. The TGF-β1 gene-509T allele and IL-10 gene-1082G allele may serve as genetic determinants for RAU.



Disease Annotations    
aphthous stomatitis  (IAGP,ISO)

Objects Annotated

Genes (Rattus norvegicus)
Il10  (interleukin 10)
Tgfb1  (transforming growth factor, beta 1)

Genes (Mus musculus)
Il10  (interleukin 10)
Tgfb1  (transforming growth factor, beta 1)

Genes (Homo sapiens)
IL10  (interleukin 10)
TGFB1  (transforming growth factor beta 1)


Additional Information