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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69051
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Tgfb1
Name: transforming growth factor, beta 1
Acc ID: CHEBI:4031
Term: cyclosporin A
Definition: A cyclic nonribosomal peptide of eleven amino acids; an immunosuppressant drug widely used in post-allogeneic organ transplant to reduce the activity of the patient's immune system, and therefore the risk of organ rejection. Also causes reversible inhibition of immunocompetent lymphocytes in the G0- and G1-phase of the cell cycle.
Chemical ID: MESH:D016572
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tgfb1increases expressionEXP 6480464CTDCyclosporine results in increased expression of TGFB1 mRNA; Cyclosporine results in increased expression of TGFB1 proteinPMID:16980036 PMID:24462674 PMID:24971338
Tgfb1increases secretionEXP 6480464CTDCyclosporine results in increased secretion of TGFB1 proteinPMID:15001429
Tgfb1multiple interactionsEXP 6480464CTD[Ciprofloxacin co-treated with Cyclosporine] results in decreased expression of TGFB1 mRNA; Celecoxib inhibits the reaction [Cyclosporine results in increased expression of TGFB1 protein]; Cyclosporine inhibits the reaction [Thioacetamide results in increased expression of TGFB1 mRNA]; Cyclosporine inhibits the reaction [Thioctic Acid promotes the reaction [Acetic Acid results in increased expression of TGFB1 mRNA]]; Cyclosporine results in decreased expression of and results in decreased secretion of TGFB1 protein; Vitamin E inhibits the reaction [Cyclosporine results in increased secretion of TGFB1 protein]PMID:15001429 PMID:15770714 PMID:18337667 PMID:24462674 PMID:26276312 PMID:28886988
Tgfb1decreases secretionISOTgfb1 (Mus musculus)6480464CTDCyclosporine results in decreased secretion of TGFB1 proteinPMID:22416070
Tgfb1increases expressionISOTGFB1 (Homo sapiens)6480464CTDCyclosporine results in increased expression of TGFB1; Cyclosporine results in increased expression of TGFB1 mRNA; Cyclosporine results in increased expression of TGFB1 proteinPMID:12227681 PMID:12352326 PMID:18342291 PMID:25562108
Tgfb1increases expressionISOTgfb1 (Mus musculus)6480464CTDCyclosporine results in increased expression of TGFB1 mRNAPMID:21354196 PMID:27585667
Tgfb1multiple interactionsISOTGFB1 (Homo sapiens)6480464CTDRamipril inhibits the reaction [Cyclosporine results in increased expression of TGFB1 mRNA]PMID:12352326
Tgfb1multiple interactionsISOTgfb1 (Mus musculus)6480464CTD[arsenic trioxide co-treated with Cyclosporine] affects the expression of TGFB1 mRNA; Cyclosporine results in increased expression of and results in increased secretion of TGFB1 protein; ethyl 6-(N-(2-chloro-4-fluorophenyl)sulfamoyl)cyclohex-1-ene-1-carboxylate inhibits the reaction [Cyclosporine results in increased expression of TGFB1 mRNA]; TLR4 gene mutant form inhibits the reaction [Cyclosporine results in increased expression of TGFB1 mRNA]PMID:19545743 PMID:21354196 PMID:27585667
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