RENAL CELL CANCER PATHWAY (PW:0001017)

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Description

Renal cell cancer (RCC), of which clear cell RCC is the most common type, accounts for ~2% of cancers. Its incidence appears to be rising and with its poor overall survival rate, it likely represents the deadliest urological neoplasm. The majority of cases are sporadic, but several familial and inherited cases have been reported. A major culprit gene is Von Hippel-Lindau (Vhl), the component of E3 ubiquitine ligase complex that targets the hypoxia inducible factor (Hif) alpha for degradation und

Pathway Diagram:

Elsevier Inc. downregulated miRNA ---> upregulated target translation potential RCC miRNA ---> Carcinoma, Renal Cell upregulated miRNA ---> downregulated target translation potential RCC miRNA drug pathways in RCC targeted therapy drug pathways in RCC targeted therapy ---| Carcinoma, Renal Cell other RCC candidate genes Vhl Sdhd Sdhb Fh altered expression of target genes altered hypoxia inducible factor pathway ---> altered expression of target genes other RCC candidate genes ---> Carcinoma, Renal Cell altered hypoxia inducible factor pathway altered citric acid cycle pathway ---> altered hypoxia inducible factor pathway upregulated miRNA downregulated miRNA upregulated target translation downregulated target translation Carcinoma, Renal Cell altered citric acid cycle pathway
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Genes in Pathway:

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renal cell carcinoma pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Akt1 AKT serine/threonine kinase 1 JBrowse link 6 137,218,398 137,239,970 RGD:6907045
G Akt2 AKT serine/threonine kinase 2 JBrowse link 1 84,400,939 84,451,223 RGD:6907045
G Akt3 AKT serine/threonine kinase 3 JBrowse link 13 95,076,308 95,348,913 RGD:6907045
G Arnt aryl hydrocarbon receptor nuclear translocator JBrowse link 2 196,594,178 196,651,486 RGD:6907045
G Arnt2 aryl hydrocarbon receptor nuclear translocator 2 JBrowse link 1 146,399,217 146,556,437 RGD:6907045
G Braf B-Raf proto-oncogene, serine/threonine kinase JBrowse link 4 67,389,331 67,520,549 RGD:6907045
G Cdc42 cell division cycle 42 JBrowse link 5 155,690,267 155,728,385 RGD:6907045
G Crebbp CREB binding protein JBrowse link 10 11,590,994 11,721,039 RGD:6907045
G Crk CRK proto-oncogene, adaptor protein JBrowse link 10 63,829,731 63,855,999 RGD:6907045
G Crkl CRK like proto-oncogene, adaptor protein JBrowse link 11 87,338,606 87,356,644 RGD:6907045
G Cul2 cullin 2 JBrowse link 17 56,952,480 56,992,716 RGD:6907045
G Egln1 egl-9 family hypoxia-inducible factor 1 JBrowse link 19 57,660,194 57,701,158 RGD:6907045
G Egln2 egl-9 family hypoxia-inducible factor 2 JBrowse link 1 83,969,456 83,977,665 RGD:6907045
G Egln3 egl-9 family hypoxia-inducible factor 3 JBrowse link 6 75,050,329 75,075,795 RGD:6907045
G Elob elongin B JBrowse link 10 13,163,032 13,168,217 RGD:6907045
G Eloc elongin C JBrowse link 5 2,042,991 2,059,357 RGD:6907045
G Ep300 E1A binding protein p300 JBrowse link 7 122,818,194 122,889,055 RGD:6907045
G Epas1 endothelial PAS domain protein 1 JBrowse link 6 10,306,508 10,385,239 RGD:6907045
G Ets1 ETS proto-oncogene 1, transcription factor JBrowse link 8 33,756,634 33,879,625 RGD:6907045
G Fh fumarate hydratase JBrowse link 13 93,651,486 93,677,371 RGD:6907135
G Flcn folliculin JBrowse link 10 46,153,185 46,172,331 RGD:6907045
G Gab1 GRB2-associated binding protein 1 JBrowse link 19 30,794,290 30,903,819 RGD:6907045
G Grb2 growth factor receptor bound protein 2 JBrowse link 10 104,193,953 104,263,071 RGD:6907045
G Hgf hepatocyte growth factor JBrowse link 4 15,435,460 15,505,377 RGD:6907045
G Hif1a hypoxia inducible factor 1 subunit alpha JBrowse link 6 96,810,868 96,856,303 RGD:6907045
G Hras HRas proto-oncogene, GTPase JBrowse link 1 214,178,404 214,181,841 RGD:6907045
G Jun Jun proto-oncogene, AP-1 transcription factor subunit JBrowse link 5 114,011,184 114,014,277 RGD:6907045
G Kdm5c lysine demethylase 5C JBrowse link X 22,302,664 22,349,298 RGD:6907133
G Kras KRAS proto-oncogene, GTPase JBrowse link 4 179,482,562 179,515,483 RGD:6907045
G Map2k1 mitogen activated protein kinase kinase 1 JBrowse link 8 69,134,218 69,722,573 RGD:6907045
G Map2k2 mitogen activated protein kinase kinase 2 JBrowse link 7 11,458,971 11,478,520 RGD:6907045
G Mapk1 mitogen activated protein kinase 1 JBrowse link 11 88,203,863 88,273,301 RGD:6907045
G Mapk3 mitogen activated protein kinase 3 JBrowse link 1 198,192,773 198,198,975 RGD:6907045
G Met MET proto-oncogene, receptor tyrosine kinase JBrowse link 4 44,747,467 44,854,628 RGD:6907045
G Nras NRAS proto-oncogene, GTPase JBrowse link 2 205,553,119 205,563,716 RGD:6907045
G Pak1 p21 (RAC1) activated kinase 1 JBrowse link 1 162,768,156 162,883,356 RGD:6907045
G Pak2 p21 (RAC1) activated kinase 2 JBrowse link 11 72,829,407 72,865,815 RGD:6907045
G Pak3 p21 (RAC1) activated kinase 3 JBrowse link X 114,784,452 115,042,683 RGD:6907045
G Pak4 p21 (RAC1) activated kinase 4 JBrowse link 1 85,162,462 85,201,746 RGD:6907045
G Pak6 p21 (RAC1) activated kinase 6 JBrowse link 3 110,442,175 110,486,317 RGD:6907045
G Pak7 p21 (RAC1) activated kinase 7 JBrowse link 3 129,042,232 129,357,512 RGD:6907045
G Pbrm1 polybromo 1 JBrowse link 16 7,103,714 7,202,899 RGD:6907133
RGD:6907137
G Pdgfa platelet derived growth factor subunit A JBrowse link 12 17,734,141 17,756,186 RGD:6907045
G Pdgfb platelet derived growth factor subunit B JBrowse link 7 121,215,458 121,233,092 RGD:6907045
G Pgf placental growth factor JBrowse link 6 108,994,016 109,004,598 RGD:6907045
G Pik3ca phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha JBrowse link 2 118,831,350 118,861,456 RGD:6907045
G Pik3cb phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta JBrowse link 8 107,275,849 107,381,088 RGD:6907045
G Pik3cd phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta JBrowse link 5 166,602,053 166,628,028 RGD:6907045
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 JBrowse link 2 31,742,326 31,826,882 RGD:6907045
G Pik3r2 phosphoinositide-3-kinase regulatory subunit 2 JBrowse link 16 20,415,109 20,424,982 RGD:6907045
G Pik3r3 phosphoinositide-3-kinase regulatory subunit 3 JBrowse link 5 135,069,972 135,145,633 RGD:6907045
G Pik3r5 phosphoinositide-3-kinase, regulatory subunit 5 JBrowse link 10 55,013,686 55,078,986 RGD:6907045
G Ptpn11 protein tyrosine phosphatase, non-receptor type 11 JBrowse link 12 40,895,515 40,955,999 RGD:6907045
G Rac1 Rac family small GTPase 1 JBrowse link 12 13,090,316 13,111,841 RGD:6907045
G Raf1 Raf-1 proto-oncogene, serine/threonine kinase JBrowse link 4 147,532,040 147,592,769 RGD:6907045
G Rap1a RAP1A, member of RAS oncogene family JBrowse link 2 208,193,950 208,215,186 RGD:6907045
G Rap1b RAP1B, member of RAS oncogene family JBrowse link 7 60,850,406 60,878,226 RGD:6907045
G Rapgef1 Rap guanine nucleotide exchange factor 1 JBrowse link 3 8,189,594 8,307,077 RGD:6907045
G Rbx1 ring-box 1 JBrowse link 7 122,700,849 122,710,907 RGD:6907045
G Sdhb succinate dehydrogenase complex iron sulfur subunit B JBrowse link 5 159,484,378 159,505,063 RGD:6907134
G Sdhd succinate dehydrogenase complex subunit D JBrowse link 8 55,028,125 55,037,604 RGD:6907134
G Setd2 SET domain containing 2, histone lysine methyltransferase JBrowse link 8 118,802,478 118,888,224 RGD:6907133
RGD:6907137
G Slc2a1 solute carrier family 2 member 1 JBrowse link 5 138,154,677 138,182,897 RGD:6907045
G Sos1 SOS Ras/Rac guanine nucleotide exchange factor 1 JBrowse link 6 3,105,443 3,182,977 RGD:6907045
G Sos2 SOS Ras/Rho guanine nucleotide exchange factor 2 JBrowse link 6 91,885,292 92,008,059 RGD:6907045
G Tgfa transforming growth factor alpha JBrowse link 4 117,961,877 118,045,923 RGD:6907045
G Tgfb1 transforming growth factor, beta 1 JBrowse link 1 82,480,875 82,497,196 RGD:6907045
G Tgfb2 transforming growth factor, beta 2 JBrowse link 13 105,039,639 105,142,010 RGD:6907045
G Tgfb3 transforming growth factor, beta 3 JBrowse link 6 109,913,757 109,936,217 RGD:6907045
G Uty ubiquitously transcribed tetratricopeptide repeat gene, Y chromosome JBrowse link Y 1,065,274 1,206,127 RGD:6907133
RGD:6907137
G Vegfa vascular endothelial growth factor A JBrowse link 9 17,340,341 17,355,681 RGD:6907045
G Vegfb vascular endothelial growth factor B JBrowse link 1 222,237,000 222,242,786 RGD:6907045
G Vegfc vascular endothelial growth factor C JBrowse link 16 40,440,371 40,555,178 RGD:6907045
G Vegfd vascular endothelial growth factor D JBrowse link X 31,816,480 31,852,239 RGD:6907045
G Vhl von Hippel-Lindau tumor suppressor JBrowse link 4 145,580,869 145,587,835 RGD:6907133
RGD:6907045

Additional Elements in Pathway:

(includes Gene Groups, Small Molecules, Other Pathways..etc.)
Object TypePathway ObjectPathway Object Description
Gene Grouppotential RCC miRNAderegulated microRNA in RCC
Small Moleculedrug pathways in RCC targeted therapydrugs used in the treatment of RCC
Gene GroupOther RCC candidate genesRCC candidate genes from large-sclae sequencing

Pathway Gene Annotations

Disease Annotations Associated with Genes in the renal cell cancer pathway
Disease TermsGene Symbols
Aberrant Crypt FociMapk1 , Mapk3 , Tgfb2
Abnormal ReflexesKdm5c
Abortion, SpontaneousArnt , Pgf , Tgfb1
acoustic neuromaVegfa
Acromicric DysplasiaTgfb1
actinic keratosisTgfb1
acute chest syndromeVegfa
acute kidney failureEgln1 , Egln3 , Epas1 , Hif1a , Met , Tgfa , Tgfb1 , Vegfa
Acute Liver FailureHgf , Met
Acute Lung InjuryPak1 , Tgfb1 , Vegfa
acute myeloid leukemiaCrebbp , Hgf , Hras , Kras , Met , Nras , Ptpn11 , Vegfa
acute promyelocytic leukemiaAkt1 , Nras
Acute-Phase ReactionHif1a
Acyl-CoA Dehydrogenase Family, Member 9, Deficiency ofPik3ca
adenocarcinomaKras , Met , Pik3ca , Ptpn11 , Tgfb1 , Vegfa
adenoid cystic carcinomaCrebbp , Ep300 , Hras , Kras , Map2k2 , Pik3ca , Setd2
adenomaKras , Vhl
adrenal carcinomaBraf , Nras , Pik3ca
Adrenal Gland NeoplasmsCdc42
adrenocortical carcinomaBraf , Nras , Pik3ca
adult T-cell leukemiaNras
adult-onset Still's diseaseHgf , Vegfa
agammaglobulinemiaPik3r1
Agammaglobulinemia 7, Autosomal RecessivePik3r1
AIDS Dementia ComplexPdgfb
alcoholic liver cirrhosisTgfb1
Alcoholic Liver DiseasesHif1a
allergic conjunctivitisTgfb1
allergic contact dermatitisVegfa
allergic hypersensitivity diseaseTgfb1
Alzheimer's diseaseAkt1 , Cdc42 , Crebbp , Ep300 , Hif1a , Hras , Mapk1 , Mapk3 , Pak1 , Pdgfb , Pik3r1 , Slc2a1 , Vegfa
ameloblastomaBraf
amphetamine abuseAkt1
amyotrophic lateral sclerosisAkt1 , Pgf , Vegfa
amyotrophic lateral sclerosis type 1Crebbp , Pdgfa , Vegfa
AnaplasiaHif1a
anemiaKras
AnetodermaTgfb1
angiosarcomaHras , Jun , Kras , Vegfa , Vegfc
angle-closure glaucomaHgf
Animal Disease ModelsAkt1 , Kras , Mapk1 , Mapk3
Animal HepatitisMet
Animal Mammary NeoplasmsCdc42 , Hras , Pdgfa , Pik3r1 , Tgfa
ankylosing spondylitisPgf
anti-basement membrane glomerulonephritisRapgef1
aortic aneurysmTgfb2
aortic valve insufficiencyTgfb1 , Tgfb2
aortic valve stenosisPtpn11
Aortic Valve, Calcification ofAkt1
Aplasia Cutis Congenita with Epibulbar DermoidsKras
aplastic anemiaTgfb1
arrhythmogenic right ventricular cardiomyopathyTgfb3
arrhythmogenic right ventricular dysplasia 1Tgfb3
Arterial ThrombosisHif1a
arteriosclerosisHgf , Met , Tgfb1
Arteriovenous FistulaVegfa
arteriovenous malformations of the brainHgf , Kras , Vegfa
AsphyxiaHif1a , Jun
asthmaHif1a , Pdgfb , Pgf , Tgfb1 , Vegfa
astroblastomaPik3r1
astrocytomaAkt1 , Akt2 , Akt3 , Braf , Hgf , Hif1a , Hras , Kras , Met , Ptpn11
AtaxiaSlc2a1
ataxia with oculomotor apraxia type 3Pik3r5
atherosclerosisAkt1 , Egln1 , Pgf , Vegfa , Vegfc
atopic dermatitisTgfb1
atrial fibrillationArnt2 , Hgf , Hif1a , Pak2 , Vegfa
atrial heart septal defectCrebbp
AtrophyMapk3
attention deficit hyperactivity disorderCrebbp , Vegfa
autism spectrum disorderMapk3
autistic disorderCrebbp , Hras , Kdm5c , Mapk1 , Met
Autoimmune DiseasesTgfb2
autoimmune hepatitisTgfb1
autoimmune lymphoproliferative syndromeNras
autoimmune lymphoproliferative syndrome type 4Kras , Nras
autoimmune thrombocytopenic purpuraTgfb1
autosomal dominant mental retardation 48Rac1
autosomal recessive Alport syndromeHras
autosomal recessive nonsyndromic deafness 26Gab1
autosomal recessive nonsyndromic deafness 39Hgf
autosomal recessive nonsyndromic deafness 97Met
autosomal recessive polycystic kidney diseaseAkt1 , Pik3ca
azoospermiaEpas1
B-Cell Chronic Lymphocytic LeukemiaBraf , Hras , Kras , Nras
B-cell lymphomaNras
background diabetic retinopathyPdgfb
bacterial pneumoniaPgf
Bannayan-Riley-Ruvalcaba syndromePik3ca , Sdhb
Bardet-Biedl syndromeAkt3
Barrett's esophagusHgf
basal cell carcinomaPik3ca
basal ganglia calcificationPdgfb
basal ganglia diseasePdgfb
Behcet's diseaseTgfb1 , Vegfa
benign epilepsy with centrotemporal spikesSlc2a1
berylliosisTgfb1
Bile Duct NeoplasmsMet
biliary tract benign neoplasmHgf
bilirubin metabolic disorderHgf
bipolar disorderAkt1 , Cdc42
Birt-Hogg-Dube syndromeFlcn
bladder carcinomaHras
bladder neck obstructionHif1a
bladder urothelial carcinomaAkt1 , Braf , Crebbp , Ep300 , Hras , Kras , Map2k1 , Nras , Pik3ca
blindnessVegfa
bone development diseaseTgfb2
brain diseaseTgfb1
brain edemaVegfa
Brain HypoxiaEp300
brain infarctionHgf , Pdgfb
Brain InjuriesAkt1 , Epas1 , Jun , Pdgfa , Pdgfb , Vegfa , Vegfb
brain ischemiaAkt1 , Hif1a , Jun , Map2k1 , Mapk1 , Mapk3 , Pak1 , Pgf , Tgfb1
Brain NeoplasmsBraf , Hras , Nras , Pik3ca , Pik3r1 , Ptpn11 , Vegfa
breast adenocarcinomaAkt1 , Kras , Pik3ca
breast cancerAkt1 , Braf , Grb2 , Hgf , Hras , Kras , Met , Pik3ca
Breast Cancer, FamilialFh , Pik3ca , Pik3r3
Breast NeoplasmsAkt1 , Akt2 , Braf , Crkl , Ep300 , Hif1a , Hras , Jun , Kdm5c , Kras , Map2k1 , Map2k2 , Mapk1 , Met , Pak1 , Pak2 , Pdgfa , Pgf , Pik3ca , Pik3r1 , Raf1 , Setd2 , Slc2a1 , Tgfb1 , Uty , Vegfa , Vegfb , Vegfc
bronchiolo-alveolar adenocarcinomaKras
Bronchitis, ChronicVegfa
Bronchopulmonary DysplasiaEpas1 , Hif1a
Bruton-type agammaglobulinemiaPik3r1
bullous pemphigoidVegfa
Burkitt lymphomaPik3r1
BurnsHif1a
CachexiaTgfb1
Cafe au lait Spots, MultipleSos1
calcinosisPdgfb , Tgfb1
Camurati-Engelmann diseaseTgfb1
cancerBraf , Hras , Nras , Pik3ca , Pik3r1
cannabis abuseAkt1
capillary hemangiomaAkt3
Capillary Hemangioma, InfantileSlc2a1
CarcinogenesisBraf , Kras
carcinomaCdc42 , Hif1a , Hras , Kras , Met , Pdgfa , Pik3r1 , Tgfb1 , Vhl
carcinosarcomaTgfb1
cardiac arrestAkt1 , Ep300
Cardiac FibrosisPak1 , Tgfb1
cardiofaciocutaneous syndromeBraf , Hras , Kras , Map2k1 , Map2k2 , Ptpn11
Cardiofaciocutaneous Syndrome 2Kras
CARDIOFACIOCUTANEOUS SYNDROME 3Map2k1
Cardiofaciocutaneous Syndrome 4Map2k2
CardiomegalyAkt1 , Ep300 , Epas1 , Hif1a , Mapk1 , Met , Pak1 , Rac1 , Raf1 , Tgfb1
cardiomyopathyAkt1 , Ep300 , Hgf , Kras , Mapk1 , Mapk3 , Vegfa
CardiotoxicityRac1
Cardiovascular AbnormalitiesMap2k1 , Ptpn11
Carney TriadSdhb
Carney-Stratakis SyndromeSdhb , Sdhd
carotid artery diseaseHgf , Pgf , Tgfb1
Carotid Body TumorSdhd
cataractMap2k1 , Slc2a1
Cecal NeoplasmsKras
celiac diseaseEts1
Cell Transformation, NeoplasticEpas1 , Hif1a , Hras , Jun , Kras , Rac1 , Slc2a1 , Tgfb1
central nervous system diseaseCrebbp , Hgf
cerebellar angioblastomaVhl
cerebellar ataxiaSlc2a1
Cerebral HemorrhageVegfa
cervix uteri carcinoma in situVegfa
Charcot-Marie-Tooth disease axonal type 2KEloc
Charcot-Marie-Tooth disease dominant intermediate CPik3r3 , Slc2a1
Chemical and Drug Induced Liver InjuryArnt , Vegfa
childhood absence epilepsySlc2a1
childhood onset GLUT1 deficiency syndrome 2Slc2a1
childhood pilocytic astrocytomaMapk1
cholangiocarcinomaHgf , Kras , Met , Pbrm1 , Tgfb1
cholangitisTgfb2
cholestasisPdgfb
cholesteatomaHgf , Vegfa
cholesteatoma of middle earHif1a , Vegfa
chorioamnionitisTgfb1
choriocarcinomaPdgfb
Choroidal NeovascularizationHgf , Vegfa , Vegfb
Chromosome 17, Trisomy 17p11 2Flcn
Chromosome AberrationsEpas1
Chronic Allograft NephropathyPdgfa , Pdgfb
Chronic Cerebral HypoperfusionHif1a
Chronic HepatitisHgf , Met , Tgfb1
Chronic Lung Allograft DysfunctionEpas1
chronic lymphocytic leukemiaBraf , Hras , Kras , Nras , Ptpn11
chronic myeloid leukemiaAkt1 , Braf , Crkl , Nras , Tgfb1 , Vegfa
chronic myelomonocytic leukemiaNras
chronic obstructive pulmonary diseaseTgfb1 , Vegfa
chronic ulcer of skinPdgfa
clear cell renal cell carcinomaEgln3 , Ep300 , Pak4 , Pak6 , Pbrm1 , Pdgfb , Vegfa
cleft palateTgfb1 , Tgfb2 , Tgfb3
CLOVES syndromePik3ca
Cocaine-Related DisordersMapk1 , Mapk3
cognitive disorderMet
colitisPgf
colon adenocarcinomaMapk1 , Mapk3 , Pik3r3 , Rac1 , Tgfb1
colon adenomaRac1
colon cancerAkt1 , Braf , Flcn , Nras , Pik3ca , Tgfb3
colon carcinomaAkt1 , Braf , Ep300 , Flcn , Nras , Pik3ca , Tgfb1 , Tgfb2
Colonic NeoplasmsAkt2 , Akt3 , Braf , Crkl , Hif1a , Jun , Kras , Pik3ca , Pik3r1 , Pik3r2 , Pik3r5 , Slc2a1 , Vegfa , Vegfc
colorectal adenocarcinomaJun , Mapk1 , Mapk3 , Raf1
colorectal adenomaJun , Raf1
colorectal cancerAkt1 , Braf , Ep300 , Flcn , Nras , Pik3ca , Rac1 , Tgfb1 , Tgfb2 , Tgfb3
Colorectal NeoplasmsAkt1 , Akt2 , Arnt , Braf , Crebbp , Ep300 , Flcn , Hras , Kras , Map2k1 , Mapk1 , Mapk3 , Met , Nras , Pik3ca , Pik3cd , Pik3r1 , Pik3r3 , Ptpn11 , Raf1 , Tgfb1 , Tgfb2
Combined Oxidative Phosphorylation Deficiency 8Sdhd
complex cortical dysplasia with other brain malformationsAkt3 , Hras , Pik3ca
Congenital Adrenal Hyperplasia due to 21 Hydroxylase DeficiencyPtpn11
congenital diaphragmatic herniaEp300 , Met , Vegfa
congenital heart diseaseHif1a , Ptpn11 , Tgfb2 , Vegfa
Congenital Limb DeformitiesTgfb2
Congenital Myopathy, with Excess of Muscle SpindlesHras
congestive heart failureEp300 , Hif1a , Pgf , Rac1 , Vegfa
connective tissue diseaseTgfb2
contact dermatitisVegfa
Copper-Overload CirrhosisHgf , Met , Tgfb1
corneal neovascularizationVegfa
coronary artery diseaseAkt1 , Hgf , Tgfb1 , Vegfa
Coronary DiseaseVegfa
coronary restenosisMapk1
coronin-1A deficiencyMapk3
Costello syndromeBraf , Hras , Kras , Map2k1 , Map2k2 , Ptpn11
Cowden diseaseAkt1 , Pik3ca , Sdhb , Sdhd
Cowden Syndrome 5Pik3ca
Cowden Syndrome 6Akt1
Cowden-Like SyndromePik3ca , Sdhb
Craniofacial AbnormalitiesEp300 , Tgfb2
craniopharyngiomaBraf
Crohn's diseaseHgf , Pgf , Vegfa
Cryohydrocytosis, Stomatin-Deficient, with Mental Retardation, Seizures, Cataracts, and Massive HepatosplenomegalySlc2a1
Currarino TriadPik3ca
cutaneous T cell lymphomaBraf
CyanosisTgfb2
cystic fibrosisTgfb1
cystic kidney diseaseVhl
CystsFlcn
DeafnessSdhb
decubitus ulcerHif1a , Vegfa
degenerative disc diseaseCrk , Tgfb1
demyelinating diseaseMapk1
dermatitis herpetiformisVegfa
dermatofibrosarcoma protuberansPdgfb
dermatomyositisHgf
Developmental DisabilitiesAkt3 , Braf , Crebbp , Ep300 , Pik3r2 , Slc2a1
Diabetes ComplicationsHif1a , Vegfa
diabetes mellitusHgf , Rac1 , Slc2a1
Diabetes Mellitus, Experimental Akt1 , Ep300 , Ets1 , Hgf , Hif1a , Hras , Mapk1 , Mapk3 , Met , Pdgfb , Pgf , Pik3r1 , Rap1b , Slc2a1 , Tgfb1 , Tgfb2 , Vegfa , Vegfb
diabetic angiopathyVegfa
Diabetic CardiomyopathiesMapk1 , Mapk3
Diabetic NephropathiesEp300 , Epas1 , Hgf , Hif1a , Mapk1 , Pdgfa , Pdgfb , Pgf , Slc2a1 , Tgfb1 , Uty , Vegfa
diabetic neuropathyHgf , Pgf , Tgfb1 , Tgfb2 , Tgfb3 , Vegfa
diabetic retinopathyEp300 , Hgf , Hif1a , Hras , Pgf , Vegfa
Diaphragmatic HerniaTgfb1
diffuse large B-cell lymphomaPik3ca , Pik3cb , Pik3cd
DiGeorge syndromeCrkl , Vegfa
Dilatation, PathologicTgfb1
dilated cardiomyopathyEgln1 , Kras , Pgf , Ptpn11 , Rac1 , Raf1
dilated cardiomyopathy 1NNRaf1
disease of cellular proliferationBraf , Hras , Kras , Map2k1 , Met , Nras , Pik3ca , Pik3r1 , Vegfa , Vhl
disease of metabolismPtpn11
Disease ProgressionHras , Pik3ca , Vegfb
Distal Arthrogryposis Multiplex Congenita, Type 1Met
Distal Arthrogryposis, Type 1AMet
dry eye syndromeTgfb1
Duchenne muscular dystrophyTgfb1
Ductal CarcinomaHif1a , Slc2a1
ductal carcinoma in situHif1a , Pak2 , Slc2a1 , Vegfa
duodenal ulcerTgfb1 , Vegfa
dysembryoplastic neuroepithelial tumorBraf
dystoniaSlc2a1
dystonia 9Slc2a1
Ehlers-Danlos syndromeTgfb1
embryonal rhabdomyosarcomaPtpn11
end stage renal failurePgf , Tgfb1
Endocrine Bone DiseasesPdgfa
endometrial adenocarcinomaMapk1 , Mapk3 , Pik3r1
endometrial cancerKras , Pik3cb , Pik3r1
endometrial carcinomaHras , Kras , Mapk1 , Mapk3 , Pik3ca , Pik3r1
endometrial hyperplasiaKras
Endometrial NeoplasmsAkt2 , Braf , Ep300 , Grb2 , Jun , Kras , Mapk3 , Met , Pik3ca , Pik3cb , Pik3cd , Vegfa
Endometrioid CarcinomasAkt1 , Kras , Mapk1 , Mapk3 , Pik3r2
endometriosisArnt , Kras , Tgfb2 , Vegfa
endomyocardial fibrosisTgfb1
EndotoxemiaEp300 , Pgf
eosinophilic esophagitisTgfb1
epidermal nevusHras , Kras , Nras , Pik3ca
epilepsyAkt1 , Pgf , Slc2a1 , Tgfb1
erythema multiformeVegfa
esophageal carcinomaEp300 , Hras , Kras , Pik3ca
Esophageal NeoplasmsMet
esophagus adenocarcinomaPik3ca
esophagus squamous cell carcinomaUty
essential thrombocythemiaPdgfa , Pdgfb , Tgfb1
Experimental ArthritisAkt1 , Cdc42 , Hif1a , Nras , Pgf , Pik3cd , Vegfa
Experimental Autoimmune EncephalomyelitisPdgfb , Tgfb1 , Tgfb2 , Vegfa
Experimental Autoimmune NeuritisEpas1 , Hif1a
Experimental ColitisMapk1 , Mapk3 , Vegfa
Experimental LeukemiaNras
Experimental Liver CirrhosisHgf , Mapk1 , Mapk3 , Met , Pdgfa , Pgf , Tgfb1 , Tgfb3 , Vegfa
Experimental Liver NeoplasmsHgf , Hras , Kras , Map2k1 , Mapk1 , Mapk3 , Met , Tgfa , Tgfb1
Experimental MelanomaHgf
Experimental NeoplasmsArnt , Braf , Hgf , Hif1a , Hras , Kras , Nras , Vegfa
Experimental SarcomaKras , Nras
Extra-Adrenal ParagangliomaSdhd
extrahepatic cholestasisJun , Mapk1 , Mapk3 , Tgfb1
extrinsic allergic alveolitisVegfa
Eye AbnormalitiesTgfb2
Facial AsymmetryPik3ca
Facial Nerve InjuriesHgf
factor VIII deficiencyTgfb1
Failure to ThrivePtpn11
familial adenomatous polyposisAkt1
familial erythrocytosis 2Vhl
familial erythrocytosis 3Egln1
familial erythrocytosis 4Epas1
familial hypercholesterolemiaFh
familial hyperlipidemiaTgfb1
familial hypertrophic cardiomyopathyKras , Raf1 , Sos1
familial meningiomaPdgfb
familial partial lipodystrophyAkt2
Familial Prostate CancerMap2k1
Fanconi anemiaVhl
fatty liver diseaseEpas1
Female InfertilityMapk1 , Mapk3
Femur Head NecrosisHif1a
Fetal Growth RetardationPdgfa , Pdgfb , Ptpn11 , Slc2a1
fibrillary astrocytomaKras
Fibromatosis, Gingival, 1Hgf , Sos1
fibrosarcomaCdc42
FibrosisAkt1 , Pdgfb , Tgfb1
focal segmental glomerulosclerosisTgfb1
follicular lymphomaCrebbp
Follicular Thyroid CancerBraf , Hras , Nras
follicular thyroid carcinomaBraf , Hras , Kras , Nras
Fumaric AciduriaFh
gallbladder carcinomaPik3ca
Gallbladder NeoplasmsHgf , Kras , Met , Tgfa , Tgfb1
gangliogliomaBraf
gastric adenocarcinomaAkt1 , Braf , Crebbp , Hras , Kras , Map2k1 , Map2k2 , Nras , Pik3ca , Ptpn11 , Raf1
gastric ulcerMapk1 , Mapk3 , Vegfa
gastrinomaMet
gastroenteritisTgfa
Gastrointestinal NeoplasmsPik3ca
gastrointestinal stromal tumorBraf , Kras , Sdhb
genetic diseaseAkt2 , Akt3 , Braf , Cdc42 , Crebbp , Egln1 , Ep300 , Hras , Kdm5c , Kras , Map2k1 , Mapk1 , Pak3 , Pik3ca , Pik3r1 , Pik3r2 , Ptpn11 , Raf1 , Setd2 , Slc2a1 , Sos1 , Tgfb2
Genetic Predisposition to DiseaseTgfa
germinomaBraf
gestational diabetesMet
Giant Pigmented Hairy NevusHras , Nras
Gilles de la Tourette syndromeMet
gingival fibromatosisSos1
Gingival HyperplasiaPdgfb
gingivitisVegfa
glaucomaCrebbp , Tgfb2 , Vegfa
glioblastoma multiformeAkt1 , Akt3 , Braf , Crebbp , Hif1a , Hras , Kras , Map2k2 , Met , Nras , Pdgfb , Pgf , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Vegfa
gliosarcomaVegfa
GliosisMapk1 , Mapk3
glomerulonephritisEp300 , Mapk1 , Pdgfb , Vegfa
glomerulosclerosisSlc2a1
Glomus Tympanicum TumorVegfa
GLUT1 Deficiency SyndromeSlc2a1
glycogen storage disease VHif1a
glycogen storage disease VIIHif1a
grade III astrocytomaKras
Graft vs Host DiseaseHgf , Pdgfb , Vegfa
granulosa cell tumorVegfa
Graves' diseaseVegfa
Growth DisordersPik3ca
growth hormone secreting pituitary adenomaPtpn11
hairy cell leukemiaMap2k1
HamartomaFlcn
Head and Neck NeoplasmsMapk1 , Mapk3 , Pik3ca , Tgfa , Vegfa
head and neck squamous cell carcinomaAkt1 , Braf , Crebbp , Ep300 , Hras , Map2k1 , Map2k2 , Mapk1 , Pik3ca , Rac1
Head Injuries, PenetratingPdgfb
Hearing LossHgf
Hearing Loss, Noise-InducedHif1a
heart diseaseEp300 , Tgfb1 , Vegfa
Heat StrokeJun
hemangioblastomaHif1a
hemangiomaSlc2a1
HemimegalencephalyPik3ca
hepatic encephalopathyHif1a
Hepatic InsufficiencyTgfb1
hepatoblastomaTgfa
hepatocellular adenomaHras , Kras , Ptpn11
hepatocellular carcinomaAkt1 , Akt2 , Braf , Crebbp , Ep300 , Hgf , Hif1a , Hras , Jun , Kras , Met , Nras , Pdgfb , Pik3ca , Rac1 , Slc2a1 , Tgfa , Tgfb1
HepatomegalyTgfb1
Hereditary Hemorrhagic Telangiectasia, Type 1Tgfb1
Hereditary Leiomyomatosis and Renal Cell CancerFh
hereditary lymphedemaVegfc
hereditary lymphedema IDVegfc
hereditary multiple exostosesPtpn11
Hereditary Neoplastic SyndromesFh , Flcn , Met , Pik3ca , Sdhb , Sdhd , Vhl
Hereditary Paraganglioma-Pheochromocytoma SyndromesSdhb , Sdhd
Hirschsprung Disease 1Crebbp , Tgfb2
Hirschsprung's diseaseSlc2a1 , Tgfb2
HirsutismEp300
Hodgkin's lymphomaJun
Holt-Oram syndromeTgfb2
Hot FlashesHif1a
human immunodeficiency virus infectious diseaseCdc42
Huntington's diseaseCrebbp , Ep300 , Kdm5c
HyperalgesiaEp300 , Hif1a , Mapk1 , Mapk3 , Raf1
HypercholesterolemiaVegfa
HyperemiaEgln1
hyperglycemiaEpas1
HyperoxaluriaRap1a
HyperoxiaTgfb1
Hyperoxic Lung InjuryPdgfb
HyperplasiaAkt1 , Hif1a , Pik3ca , Tgfb1 , Vegfa
hypertensionAkt1 , Akt2 , Egln1 , Ep300 , Hgf , Hif1a , Jun , Kras , Pdgfb , Pgf , Pik3r1 , Slc2a1 , Tgfb1 , Tgfb3 , Vegfa , Vhl
hypertrophic cardiomyopathyPtpn11 , Raf1 , Tgfb1 , Tgfb3
hypertrophic cardiomyopathy 4Braf
HypertrophyMapk1 , Mapk3
hypoglycemiaAkt2 , Pik3r1
hypogonadismNras
hypogonadotropic hypogonadismNras
hypogonadotropic hypogonadism 7 with or without anosmiaNras
Hypoinsulinemic Hypoglycemia with HemihypertrophyAkt2
hypomyelinating leukodystrophy 8 with or without oligodontia and-or hypogonadotropic hypogonadismPik3r2
hypothyroidismSlc2a1
HypoxiaPgf
Hypoxia-Ischemia, BrainHif1a , Pdgfb , Vegfa
Idiopathic Basal Ganglia Calcification 1Pdgfb
Idiopathic Basal Ganglia Calcification 5Pdgfb
idiopathic generalized epilepsySlc2a1
idiopathic pulmonary fibrosisHif1a
IgA glomerulonephritisTgfb1
Immunodeficiency 14Pik3cd
Immunodeficiency 36Pik3r1
impotenceAkt1 , Tgfb1 , Vegfa
in situ carcinomaAkt1
Infant, Newborn, DiseasesTgfb1
InfarctionEpas1 , Hif1a
InflammationAkt1 , Pdgfb , Pgf , Tgfa , Tgfb1 , Vegfa
inflammatory bowel diseaseCul2 , Pdgfb , Tgfb1 , Vegfa
inherited metabolic disorderSlc2a1
Insulin ResistanceAkt2 , Mapk3 , Pik3r1
insulinomaTgfa , Tgfb1
intellectual disabilityEp300 , Kdm5c , Kras , Pgf , Slc2a1 , Tgfb3
intermediate coronary syndromeAkt1
intermittent claudicationEpas1
interstitial lung diseaseHgf , Tgfb1
Intervertebral Disc DiseaseHif1a
Intervertebral Disc DisplacementAkt1
Intestinal Carcinoid TumorsSdhd
Intestinal NeoplasmsMap2k1 , Map2k2
Intestinal PolypsJun
intrahepatic cholangiocarcinomaKras
invasive ductal carcinomaAkt1 , Crkl , Hif1a
Invasive Pulmonary AspergillosisVegfa
inverted papillomaVegfa
Iron OverloadEpas1
ischemiaAkt2 , Raf1
ischemic colitisVegfa
juvenile myelomonocytic leukemiaKras , Nras , Ptpn11
juvenile rheumatoid arthritisJun , Kras , Mapk1
Kaposi's sarcomaHgf
Kawasaki diseaseVegfa
keratoconusHgf , Pak6
kidney diseaseMapk1 , Tgfb1
kidney failureHif1a
Kidney NeoplasmsAkt1 , Braf , Jun , Kras , Mapk1 , Mapk3 , Met , Raf1 , Vhl
Kidney Reperfusion InjuryEgln1 , Egln3 , Ep300 , Hif1a , Pdgfb
Klinefelter's syndromeNras
Knee OsteoarthritisEpas1 , Tgfa
Kuhnt-Junius degenerationPdgfb , Vegfa
L-2-hydroxyglutaric aciduriaSos2
Langerhans-cell histiocytosisBraf
large cell carcinomaMet
Lead Poisoning, Nervous SystemEp300
learning disabilityVegfa
Left Ventricular HypertrophyPbrm1 , Rac1
left ventricular noncompactionTgfb3
leiomyomaPdgfa , Pdgfb
leiomyoma cutisFh
LentigoHgf
LEOPARD syndromeBraf , Ptpn11 , Raf1
LEOPARD SYNDROME 3Braf
LEOPARD Syndrome, 2Raf1
leukemiaNras , Ptpn11 , Setd2
LeukocytosisKras , Nras
LeukoencephalopathiesSdhb
Leydig cell tumorPdgfa , Pdgfb
Limb IschemiaHgf , Hif1a , Vegfa
limited sclerodermaPgf
liver benign neoplasmBraf , Egln3 , Flcn , Hgf , Hras , Jun , Kras , Met , Raf1 , Slc2a1 , Tgfa
liver cancerAkt1 , Crebbp , Hras , Kras , Nras , Pik3ca
liver cirrhosisArnt , Hgf , Pdgfb , Pgf , Tgfb1 , Vegfa
liver diseaseRac1
Liver FailureVegfa
Liver InjuryHgf , Pdgfb
localized sclerodermaHgf , Tgfb1
Loeys-Dietz syndromeTgfb2 , Tgfb3
Loeys-Dietz syndrome 4Tgfb2 , Tgfb3
Loeys-Dietz syndrome 5Tgfb3
lung adenocarcinomaAkt1 , Braf , Hras , Kras , Map2k1 , Nras , Pik3ca , Pik3r1 , Ptpn11 , Raf1 , Sos1
lung cancerBraf , Kras , Pik3ca
lung diseaseHif1a , Pdgfa , Tgfb1 , Vegfa
Lung InjuryTgfa
Lung NeoplasmsAkt1 , Braf , Crkl , Hras , Jun , Kras , Mapk1 , Mapk3 , Met , Pik3ca , Raf1 , Tgfb1 , Vhl
lung small cell carcinomaAkt1 , Crebbp , Ep300 , Pik3ca , Pik3r1
lung squamous cell carcinomaAkt1 , Braf , Crebbp , Ep300 , Hras , Kras , Pik3ca , Ptpn11
Luscan-Lumish syndromeSetd2
LymphangiectasisRaf1
lymphangioleiomyomatosisVegfd
Lymphatic MetastasisPdgfa , Pdgfb , Pik3ca , Pik3cb , Vegfa , Vegfc , Vegfd
lymphedemaMet , Pgf
lymphomaKras , Nras , Ptpn11
MacrocephalyAkt3
Macrocephaly/Megalencephaly Syndrome, Autosomal RecessiveAkt3
macular degenerationVegfa
macular retinal edemaVegfa
malignant gliomaAkt2 , Braf , Hgf , Hras , Kras , Map2k1 , Mapk3 , Met , Pdgfa , Pdgfb , Pik3ca , Pik3r3 , Raf1
malignant mesotheliomaHgf , Met , Raf1 , Setd2 , Slc2a1 , Tgfb2
Mammary Neoplasms, ExperimentalAkt1 , Akt2 , Cdc42 , Hif1a , Hras , Mapk1 , Mapk3 , Pak4 , Pdgfa , Pik3r1 , Tgfa , Tgfb1 , Vegfa
Mandibular NeoplasmsBraf
mantle cell lymphomaPik3cd
medulloblastomaCrebbp , Ep300 , Nras , Pik3ca
Megakaryoblastic Leukemia of Down SyndromeNras
Megalancephaly Polymicrogyria-Polydactyly Hydrocephalus SyndromeAkt3 , Pik3ca , Pik3r2
Megalencephaly Cutis Marmorata Telangiectatica CongenitaAkt3 , Pik3ca , Pik3r2
MEGALENCEPHALY-POLYMICROGYRIA-POLYDACTYLY-HYDROCEPHALUS SYNDROME 2Akt3
melanomaAkt1 , Arnt , Braf , Crebbp , Ep300 , Flcn , Hras , Kras , Map2k1 , Map2k2 , Nras , Pik3ca , Pik3r1 , Rac1 , Raf1 , Sdhd , Vegfa , Vegfc
membranoproliferative glomerulonephritisEp300
Memory DisordersHif1a , Vegfa
Meningeal NeoplasmsAkt1
meningiomaAkt1 , Hgf , Pdgfb
mental depressionJun
Mental Retardation, X-LinkedPak3
Mental Retardation, X-Linked 47Pak3
Mercury Poisoning, Nervous SystemJun
Merkel cell carcinomaSdhd
mesangial proliferative glomerulonephritisRapgef1
MesotheliomaPdgfa
Metabolic SyndromeHgf , Tgfb1 , Vegfa
MetachondromatosisPtpn11
microcephalyEp300 , Slc2a1
MicrognathismEp300
Micronuclei, Chromosome-DefectiveHif1a
Microsatellite InstabilityBraf , Setd2
Microvascular Complications of Diabetes, Susceptibility to, 1Vegfa
Microvascular Complications of Diabetes, Susceptibility to, 2Vegfa
Microvascular Complications of Diabetes, Susceptibility to, 7Vegfa
microvillus inclusion diseaseCdc42
middle cerebral artery infarctionHif1a , Mapk1 , Mapk3 , Slc2a1
migraineMap2k2 , Slc2a1
mitochondrial complex II deficiencySdhd
Monoclonal B-Cell LymphocytosisRapgef1
morbid obesityHif1a
Mouth NeoplasmsEts1 , Hras , Kras , Nras , Pik3ca
mucositisTgfa
Multicystic Dysplastic KidneyPdgfa
Multiple AbnormalitiesCdc42 , Crebbp , Ep300 , Kras , Mapk1 , Pik3r2
Multiple Hamartoma SyndromePik3ca , Sdhb
multiple myelomaBraf , Hras , Kras , Met , Nras , Pik3ca , Ptpn11 , Tgfb1 , Vegfa
Multiple Organ FailureMapk1
multiple sclerosisVegfa
Muscle HypotoniaEp300
Muscle SpasticityCrebbp
Muscle WeaknessSlc2a1
muscular atrophyAkt1
muscular diseaseTgfb1
Musculoskeletal AbnormalitiesEpas1 , Tgfb2
mycosis fungoidesHif1a
myelodysplastic syndromeCrebbp , Hras , Kras , Nras
myelofibrosisTgfb1
myeloid leukemiaVegfa
myeloid neoplasmKras , Nras
myeloid sarcomaKras
myelomeningoceleSlc2a1
myocardial infarctionAkt1 , Egln1 , Egln3 , Epas1 , Hgf , Hif1a , Mapk1 , Pgf , Tgfb1 , Tgfb2 , Vegfa , Vegfb
Myocardial IschemiaCrk , Hgf , Hif1a , Pgf , Vegfa
Myocardial Reperfusion InjuryAkt1 , Akt2 , Egln1 , Hif1a , Mapk1 , Mapk3 , Rap1a , Slc2a1 , Tgfb1 , Vegfa
myopiaEp300 , Hgf
myositisHgf
Nasal PolypsHgf , Jun , Met , Tgfb1 , Vegfa
Nasopharyngeal NeoplasmsHras , Nras , Pik3ca
NecrosisCdc42
Nematode InfectionsPik3r1
NeointimaPak1 , Pdgfb
Neoplasm InvasivenessHgf , Hif1a , Hras , Mapk1 , Mapk3 , Met , Tgfb1
Neoplasm MetastasisAkt2 , Braf , Hgf , Kras , Mapk1 , Mapk3 , Met , Pdgfb , Pik3ca , Pik3r3 , Rac1 , Tgfb1 , Vegfa
Neoplasm Recurrence, LocalVegfa
Neoplasms, Cystic, Mucinous, and SerousMet
Neoplastic ProcessesHras
neovascular glaucomaVegfa
Neovascularization, PathologicVegfa
nephroblastomaHif1a , Pak1 , Slc2a1 , Vegfc , Vhl
nephrolithiasisTgfb1
nephronophthisis-like nephropathy 1Ep300 , Rbx1
Nephrosis, Puromycin AminonucleosidePak2
nephrotic syndromeTgfb1
Nerve DegenerationMapk1 , Mapk3 , Tgfa , Vegfa
Nerve Sheath NeoplasmsHgf , Met
nervous system diseaseSlc2a1
NeuralgiaTgfb1
neuroblastomaHgf , Hras , Kras , Met , Nras , Pik3ca , Ptpn11
Neurocutaneous MelanosisNras
Neurodevelopmental DisordersPtpn11 , Setd2
neuroendocrine tumorBraf
neurofibromaPtpn11
Neurofibromatosis 1Vegfa
Neurofibromatosis 2Vegfa
neurofibrosarcomaNras , Vegfa
neuronal ceroid lipofuscinosis 6Mapk1 , Mapk3
NevusBraf
Nevus, PigmentedNras
newborn respiratory distress syndromeEpas1 , Vegfa
non-Hodgkin lymphomaBraf , Map2k1 , Nras , Pik3ca
non-small cell lung carcinomaAkt1 , Akt2 , Akt3 , Braf , Epas1 , Hif1a , Hras , Kras , Map2k1 , Met , Nras , Pik3ca , Raf1 , Tgfa , Vegfa
non-syndromic X-linked intellectual disabilityPak3
nonalcoholic fatty liver diseaseTgfb1
nonpapillary renal cell carcinomaFlcn , Vhl
Nonseminomatous Germ Cell TumorBraf
nonsyndromic deafnessMet , Tgfa , Tgfb3
Noonan Like SyndromeCdc42 , Ptpn11 , Sos1
Noonan syndromeBraf , Hras , Kras , Map2k1 , Map2k2 , Nras , Ptpn11 , Raf1 , Sos1
Noonan syndrome 1Braf , Map2k1 , Nras , Ptpn11 , Raf1
Noonan syndrome 3Hras , Kras , Ptpn11 , Raf1 , Sos1
Noonan syndrome 4Hgf , Sos1
Noonan syndrome 5Raf1
Noonan syndrome 6Nras
Noonan syndrome 7Braf
Noonan syndrome 9Sos2
Noonan Syndrome-Like Disorder with or without Juvenile Myelomonocytic LeukemiaPtpn11
Nose NeoplasmsHgf
obesityAkt1 , Akt2 , Ep300 , Hgf , Mapk1 , Mapk3 , Pgf , Pik3r1 , Slc2a1 , Tgfb1
obsessive-compulsive disorderHras
Occupational AsthmaTgfb1
Occupational DiseasesTgfb1
olfactory neuroblastomaHif1a
oligohydramniosPdgfa , Pdgfb
Ollier diseasePtpn11
Optic Nerve InjuriesEp300 , Hgf , Jun , Pdgfb
oral squamous cell carcinomaMet
oral submucous fibrosisTgfb1
osteoarthritisEpas1 , Hif1a , Slc2a1
Osteoarthritis, ExperimentalMapk3
osteochondrodysplasiaTgfb1 , Tgfb2 , Vegfa
OsteochondromaPtpn11
Osteofibrous DysplasiaMet
osteopetrosisJun
osteoporosisTgfb1
osteosarcomaAkt1 , Jun , Met , Vegfa
otitis mediaVegfa
Otitis Media with EffusionVegfa
ovarian cancerAkt1 , Kras , Pik3ca
Ovarian NeoplasmsAkt1 , Akt2 , Braf , Crkl , Hif1a , Hras , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Met , Pak1 , Pik3ca , Pik3r1 , Slc2a1 , Vegfa , Vegfc , Vegfd
ovarian serous cystadenocarcinomaBraf , Hras , Nras , Pik3ca
Oxygen-Induced RetinopathyHif1a , Vegfa
PainAkt1 , Hgf
Painful NeuropathyEp300
pancreatic acinar cell adenocarcinomaBraf
pancreatic adenocarcinomaHras , Kras , Map2k2 , Pik3ca
pancreatic cancerAkt1 , Akt2 , Akt3 , Braf , Cdc42 , Hgf , Hif1a , Kras , Met , Pbrm1 , Tgfa , Tgfb1 , Vegfb , Vhl
pancreatic carcinomaKras
pancreatic ductal carcinomaKras , Met , Tgfb1 , Vegfa , Vhl
pancreatic intraductal papillary-mucinous neoplasmAkt1
pancreatitisHgf , Met , Pdgfa , Pdgfb
Pancreatitis, Experimental, Acute Kras
pancytopeniaEpas1
papillary carcinomaVegfc
papillary renal cell carcinomaBraf , Eloc , Hras , Met , Nras , Pik3ca , Sdhb , Vhl
papillary thyroid carcinomaBraf
papillomaHras , Tgfa , Tgfb1
paragangliomaSdhb , Sdhd
Paragangliomas 4Sdhb
Paragangliomas with Sensorineural Hearing LossSdhd
paraplegiaAkt1 , Kdm5c
Paraquat LungTgfb1
Parasitic Liver DiseasesKras
Parkinson's diseaseAkt1 , Hgf
Parkinsonian DisordersVhl
penile neoplasmHras , Kras , Pik3ca
Periapical DiseasesPdgfb
Periodontal AtrophyVegfa
periodontitisMet
peripheral nervous system diseaseJun
Peritoneal FibrosisTgfb1
Peritoneal NeoplasmsSlc2a1
Peyronie's diseaseTgfb1
pheochromocytomaSdhb , Sdhd , Vhl
phobic disorderHras
Phyllodes TumorHif1a , Setd2
pilocytic astrocytomaKras
plasmacytomaBraf , Hras , Kras , Nras , Pik3ca , Ptpn11
pleomorphic xanthoastrocytomaBraf , Hgf , Met
pleural diseaseTgfb1
Pneumococcal PneumoniaMapk1 , Mapk3
pneumoniaTgfb1
pneumothoraxFlcn
polyarteritis nodosaVegfa
polycystic kidney diseaseEpas1 , Hif1a
polycystic ovary syndromeAkt2 , Gab1 , Vegfa
polycythemiaEgln1 , Epas1 , Vhl
PolymicrogyriaAkt3
PolymyositisHgf
Polyomavirus InfectionsHgf
Polypoidal Choroidal VasculopathyVegfa
portal hypertensionPik3r1 , Vegfa
Posterior Leukoencephalopathy SyndromeTgfb1
Postmenopausal OsteoporosisHif1a , Tgfb1
Potocki-Lupski syndromeFlcn
pre-eclampsiaEpas1 , Pgf , Vegfa
pre-malignant neoplasmAkt1 , Hras , Vegfa
precursor lymphoblastic lymphoma/leukemiaArnt , Crebbp , Kras , Nras , Uty
precursor T-lymphoblastic lymphoma/leukemiaKras , Ptpn11
Pregnancy in DiabeticsVegfa
Premature BirthPgf
primary biliary cirrhosisHif1a , Tgfb1
primary polycythemiaEgln1 , Epas1
primary spontaneous pneumothoraxFlcn
proliferative diabetic retinopathyPdgfb , Vegfa
proliferative vitreoretinopathyHgf
prostate adenocarcinomaAkt1 , Akt2 , Akt3 , Braf , Grb2 , Hras , Map2k1 , Mapk1 , Pik3ca , Pik3cb , Raf1
prostate cancerAkt2 , Akt3 , Grb2 , Hif1a , Kras , Pak4 , Pik3ca , Pik3cb , Pik3r1 , Pik3r2 , Raf1 , Sos1
prostate carcinomaAkt2 , Pdgfb
prostate carcinoma in situKras
prostatic hypertrophyPdgfb
Prostatic NeoplasmsAkt1 , Braf , Crebbp , Crkl , Ep300 , Hif1a , Hras , Jun , Kras , Map2k1 , Mapk3 , Met , Nras , Pak6 , Pdgfa , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Setd2 , Tgfa , Tgfb1 , Uty , Vegfa
proteinuriaPak1 , Pak2 , Tgfb1 , Vegfa
Proteus syndromeAkt1
pseudoxanthoma elasticumVegfa
psoriasisEpas1 , Hif1a , Tgfa , Tgfb1 , Vegfa
PTEN hamartoma tumor syndromePik3ca , Sdhb
pterygiumVegfa , Vegfc
pulmonary edemaTgfa , Vegfa
pulmonary emphysemaJun , Pgf , Tgfb1
pulmonary eosinophiliaEpas1
pulmonary fibrosisHgf , Pdgfa , Pdgfb , Tgfa , Tgfb1
pulmonary hypertensionEpas1 , Hif1a , Mapk1 , Mapk3 , Pdgfa , Pdgfb , Pgf , Tgfa , Tgfb1 , Vegfb
Pulmonary Hypertension, Hypoxia-Induced Egln1 , Egln3
pulmonary sarcoidosisTgfb1
pulmonary tuberculosisJun
pulmonary valve stenosisBraf , Hras , Sos1
pyelonephritisPgf
Radiation InjuriesHif1a
Radiation Injuries, ExperimentalHif1a , Mapk1 , Mapk3
Radiation PneumonitisTgfb1
RASopathiesBraf , Hras , Kras , Map2k1 , Map2k2 , Nras , Ptpn11 , Raf1 , Sos1
rectal neoplasmNras , Pik3ca , Pik3cb
RecurrenceHras , Kras , Vegfc
renal carcinomaMet , Nras , Pik3ca , Sdhb
renal cell carcinomaAkt1 , Akt3 , Arnt , Egln1 , Egln2 , Egln3 , Eloc , Epas1 , Fh , Flcn , Hif1a , Jun , Kdm5c , Kras , Map2k1 , Mapk1 , Met , Nras , Pak1 , Pbrm1 , Pgf , Pik3ca , Pik3r1 , Sdhb , Sdhd , Setd2 , Slc2a1 , Tgfb1 , Uty , Vegfa , Vegfc , Vhl
renal fibrosisEpas1 , Kras , Mapk1
renal oncocytomaFlcn
renovascular hypertensionPdgfa
Reperfusion InjuryAkt1 , Cdc42 , Ep300 , Ets1 , Hgf , Hif1a , Jun , Met , Pik3r1 , Slc2a1 , Vegfc , Vegfd
Respiratory System AbnormalitiesTgfb2 , Tgfb3
Retina Reperfusion InjuryHgf , Vegfa
retinal degenerationHgf , Pak3 , Pak4
retinal diseaseEpas1 , Pdgfb , Vegfa
retinal ischemiaHif1a , Vegfa
Retinal NeovascularizationHgf , Hif1a , Vegfa , Vegfb
retinal telangiectasiaVegfa
retinal vein occlusionVegfa , Vegfb
retinitis pigmentosaHgf , Vegfa
retinopathy of prematurityHgf , Vegfa
RetrognathiaEp300
rhabdomyosarcomaVegfa
rheumatoid arthritisEpas1 , Hgf , Hif1a , Pdgfb , Pgf , Vegfa
rhinitisCdc42 , Tgfb1 , Vegfa
RhinosinusitisHgf
Right Ventricular HypertrophyAkt1 , Tgfa , Tgfb1
Rubinstein-Taybi syndromeCrebbp , Ep300
sarcoidosisTgfb1
sarcomaMet , Pik3ca
schizophreniaAkt1 , Crkl , Hgf , Kdm5c , Mapk3 , Met , Pak1 , Pak2 , Pik3cb
sciatic neuropathyHgf
sclerosing cholangitisHif1a
scoliosisCrebbp , Ptpn11
Seasonal Allergic RhinitisVegfa
Sebaceous Nevus of JadassohnHras , Kras , Nras
Sebaceous Nevus Syndrome and HemimegalencephalyHras , Kras , Nras
seborrheic keratosisPik3ca
seminomaHras , Kras , Vegfa
Senior-Loken syndromeAkt3
Senior-Loken Syndrome 7Akt3
Sensenbrenner syndromeTgfb3
SepsisEp300 , Mapk1 , Mapk3 , Pgf , Tgfb1
Septic PeritonitisPik3r1
Sezary's diseaseBraf , Crebbp , Mapk1
ShockMapk1 , Mapk3
Shock, HemorrhagicMapk1
SHORT SyndromePik3r1
sickle cell anemiaPgf , Tgfb1
sinusitisMet , Pdgfb
Sjogren's syndromeTgfb1
skin benign neoplasmHras
skin melanomaAkt1 , Braf , Hif1a , Hras , Map2k1 , Map2k2 , Nras , Pik3ca , Rac1 , Raf1
Skin NeoplasmsAkt1 , Crkl , Hgf , Hif1a , Hras , Tgfb1 , Vegfa
Small-For-Size SyndromeVegfa
Smith-Magenis syndromeGrb2 , Kdm5c , Map2k2
spermatocytomaHras
spina bifidaCrebbp
Spinal Cord InjuriesAkt1 , Cdc42 , Hgf , Hif1a , Jun , Met , Pdgfb , Tgfb1 , Tgfb2 , Vegfa , Vhl
Splenic NeoplasmsHras
SplenomegalyKras , Nras
Spondylocostal Dysostosis 5Mapk3
Sporadic Papillary Renal Cell CarcinomaBraf , Hras , Pik3ca
squamous cell carcinomaAkt1 , Crebbp , Ep300 , Hgf , Hras , Kras , Mapk1 , Mapk3 , Met , Pik3ca , Ptpn11 , Tgfb1 , Vegfa
Stargardt diseaseFh
Stargardt Disease 1Fh
status epilepticusJun , Pgf , Vegfa
Stevens-Johnson syndromeEp300 , Rbx1
stomach cancerKras , Pik3ca
stomach carcinomaKras
Stomach NeoplasmsHras , Jun , Kras , Mapk1 , Mapk3 , Met , Nras , Pik3ca , Tgfa
StrokeAkt1 , Hgf , Pak1 , Pgf , Pik3ca , Tgfa , Tgfb1 , Vegfa
Subarachnoid HemorrhageHif1a
substance-induced psychosisAkt1
sudden infant death syndromeVegfa , Vhl
syndromic X-linked intellectual disability Claes-Jensen typeKdm5c
Systemic Juvenile Rheumatoid ArthritisHgf
systemic lupus erythematosusEp300 , Ets1 , Pgf
systemic sclerodermaHgf , Vegfa
T-Cell LymphomaAkt1 , Ep300
Takenouchi-Kosaki SyndromeCdc42
temporal lobe epilepsyCdc42 , Pgf , Vegfa
Temporomandibular Joint DisordersHif1a
Testis Reperfusion InjuryHif1a , Mapk1 , Mapk3
tetralogy of FallotPtpn11
thoracic aortic aneurysmTgfb2
thrombocytopeniaTgfb1
thrombosisHgf , Pik3cb
Thrombotic MicroangiopathiesVegfa
Thumb DeformityCrebbp , Ep300
thymomaHras , Pbrm1
thyroid cancerMapk1
thyroid medullary carcinomaKras
Thyroid NeoplasmsAkt1 , Akt2 , Braf , Hif1a , Hras , Kras , Nras , Pdgfa , Pik3ca
Tibial FracturesPdgfb , Pgf
Tobacco Addiction, Susceptibility ToEgln2
Tongue NeoplasmsHras , Vegfa , Vegfc
tongue squamous cell carcinomaHgf , Met
toxic encephalopathyEgln1
tracheal stenosisTgfb1
transient cerebral ischemiaEp300 , Hif1a
transitional cell carcinomaAkt1 , Braf , Crebbp , Ep300 , Hras , Kras , Map2k1 , Mapk1 , Nras , Pak1 , Pik3ca
Trichilemmoma Hras
trigeminal neuralgiaMapk1 , Mapk3
Tubulointerstitial FibrosisTgfb1
Tumor Predisposition SyndromeFh , Flcn , Met , Sdhb , Sdhd , Vhl
Tympanic Membrane PerforationVegfa
type 1 diabetes mellitusEts1 , Tgfb1
type 2 diabetes mellitusAkt1 , Akt2 , Arnt , Braf , Ep300 , Epas1 , Ets1 , Hgf , Hif1a , Mapk1 , Mapk3 , Pik3cb , Pik3r1 , Slc2a1 , Tgfb1 , Vegfa
UlcerHif1a
ulcerative colitisVegfa
uremiaTgfb1
ureteral obstructionAkt1 , Mapk1 , Mapk3 , Pak2 , Pdgfb , Tgfb1 , Tgfb2
urethral obstructionMapk1 , Tgfb1
urinary bladder cancerAkt1 , Crebbp , Ep300 , Hras , Kras , Vegfa , Vegfc , Vegfd , Vhl
Urinary Bladder NeoplasmHras , Kras
Urinary IncontinenceMapk1
Urogenital AbnormalitiesTgfb2
Urologic NeoplasmsHif1a , Vegfa
urticariaTgfb1
Usher syndromeTgfb2
uterine carcinosarcomaHras , Pik3ca , Pik3r1
Uterine Cervical NeoplasmsAkt1 , Crebbp , Ep300 , Hras , Kras , Mapk1 , Nras , Pik3ca , Sos1 , Vegfa
uterine fibroidFh
Uterine LeiomyomaFh
Uterine NeoplasmsBraf , Hras , Kras , Map2k1 , Nras , Pik3ca , Pik3r1 , Rac1 , Sos1
uveal melanomaVegfa
uveitisTgfb1
varicoceleHif1a
vascular diseaseHgf
Vascular MalformationsPik3ca
velocardiofacial syndromeCrkl , Mapk1
Ventilator-Induced Lung InjuryAkt1
Ventricular Dysfunction, LeftRac1
Ventricular Premature ComplexesTgfb3
Ventricular RemodelingTgfb1
ventricular septal defectBraf , Pgf , Tgfb3
Ventricular TachycardiaRaf1
visual epilepsyHgf , Pdgfb , Pik3ca , Slc2a1
vitiligoHgf , Pik3r1 , Tgfb1
von Hippel-Lindau diseaseEpas1 , Vhl
Wallerian DegenerationPgf , Tgfb1 , Tgfb2
Weight GainPik3ca
Weissenbacher-Zweymuller syndromeMapk1
Werner syndromeHif1a
withdrawal disorderMapk1 , Mapk3
Wounds and InjuriesHgf , Pdgfa , Pdgfb , Tgfb1 , Tgfb2 , Tgfb3 , Vegfa
Wounds, PenetratingHgf , Pgf
Pathway Annotations Associated with Genes in the renal cell cancer pathway
Pathway TermsGene Symbols
acute myeloid leukemia pathwayAkt1 , Akt2 , Akt3 , Braf , Grb2 , Hras , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Raf1 , Sos1 , Sos2
adenosine signaling pathwayAkt1 , Braf , Cdc42 , Hras , Jun , Map2k2 , Mapk1 , Pak1 , Pik3ca , Rap1a
aldosterone signaling pathwayCrebbp , Kras , Mapk1 , Mapk3 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5
altered citric acid cycle pathwayFh , Sdhb , Sdhd
altered epidermal growth factor/neuregulin signaling pathwayTgfa
altered extracellular signal-regulated Raf/Mek/Erk signaling pathwayBraf , Kras , Map2k1 , Raf1
altered hypoxia inducible factor pathwayVhl
altered insulin responsive facilitative sugar transporter mediated glucose transport pathwayAkt2
altered p53 signaling pathwayEts1
altered phosphatidylinositol 3-kinase signaling pathwayPik3ca
altered phosphatidylinositol 3-kinase-Akt signaling pathwayAkt1 , Akt2 , Akt3 , Pik3ca
altered scatter factor/hepatocyte growth factor signaling pathwayMet
altered SWI/SNF family mediated chromatin remodeling pathwayPbrm1
altered transforming growth factor-beta Smad dependent signaling pathwayTgfb1
altered vascular endothelial growth factor signaling pathway involving proteins affecting its expressionVegfa
altered vascular endothelial growth factor signaling pathway involving the main playersVegfa
Alzheimer's disease pathwayMapk1 , Mapk3 , Sdhb , Sdhd
amyotrophic lateral sclerosis pathwayRac1
androgen signaling pathwayCrebbp , Ep300
apoptotic cell death pathwayAkt1 , Akt2 , Akt3 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5
Arf family mediated signaling pathwayRac1
aryl hydrocarbon receptor signaling pathwayArnt , Arnt2
azathioprine pharmacodynamics pathwayRac1
B cell receptor signaling pathwayAkt1 , Akt2 , Akt3 , Grb2 , Hras , Jun , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Rac1 , Raf1 , Sos1 , Sos2
bevacizumab pharmacodynamics pathwayVegfa
bile acid transport pathwaySlc2a1
Bone morphogenetic proteins signaling pathwayMapk1
brain-derived neurotrophic factor signaling pathwayGrb2
c-Jun N-terminal kinases MAPK signaling pathwayCdc42 , Rac1 , Rapgef1
cell cycle pathway, mitoticCrebbp , Ep300 , Rbx1 , Tgfb1 , Tgfb2 , Tgfb3
ceramide signaling pathwayAkt1 , Akt2 , Akt3 , Braf , Cdc42 , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Pdgfa , Pgf , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Rac1 , Raf1 , Tgfa , Tgfb1 , Tgfb2 , Tgfb3 , Vegfa , Vegfb , Vegfc , Vegfd
Chagas disease pathwayAkt1 , Akt2 , Akt3 , Jun , Mapk1 , Mapk3 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Tgfb1 , Tgfb2 , Tgfb3
chemokine mediated signaling pathwayAkt1 , Akt2 , Akt3 , Braf , Cdc42 , Crk , Crkl , Grb2 , Hras , Kras , Map2k1 , Mapk1 , Mapk3 , Nras , Pak1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Rac1 , Raf1 , Rap1a , Rap1b , Sos1 , Sos2
chronic myeloid leukemia pathwayAkt1 , Akt2 , Akt3 , Braf , Crk , Crkl , Grb2 , Hras , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Ptpn11 , Raf1 , Sos1 , Sos2 , Tgfb1 , Tgfb2 , Tgfb3
citric acid cycle pathwayFh , Sdhb , Sdhd
colorectal cancer pathwayAkt1 , Akt2 , Akt3 , Braf , Jun , Kras , Map2k1 , Mapk1 , Mapk3 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Rac1 , Raf1 , Tgfb1 , Tgfb2 , Tgfb3
cortisol signaling pathwayCrebbp , Ep300
cytokine mediated signaling pathwayHgf , Met , Pdgfa , Tgfb1 , Tgfb2 , Tgfb3 , Vegfc , Vegfd
dilated cardiomyopathy pathwayTgfb1 , Tgfb2 , Tgfb3
E-cadherin signaling pathwayAkt1 , Akt2 , Cdc42 , Crk , Hgf , Pik3ca , Pik3r1 , Rac1 , Rap1a , Rap1b
eicosanoid signaling pathwayAkt1 , Pik3r5 , Rac1
electron transport chain pathwaySdhb , Sdhd
endocytosis pathwayCdc42 , Hras , Met , Tgfb1 , Tgfb2 , Tgfb3
endometrial cancer pathwayAkt1 , Akt2 , Akt3 , Braf , Grb2 , Hras , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Raf1 , Sos1 , Sos2
Endoplasmic Reticulum-associated degradation pathwayRbx1
endothelin signaling pathwayAkt1 , Cdc42 , Crk , Hras , Jun , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Rac1 , Raf1
Entamoebiasis pathwayPik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Tgfb1 , Tgfb2 , Tgfb3
ephrin - ephrin receptor bidirectional signaling axisCdc42 , Crk , Crkl , Grb2 , Hras , Map2k1 , Mapk1 , Mapk3 , Nras , Pak1 , Pik3ca , Pik3r1 , Pik3r5 , Rac1 , Rap1a , Rap1b
epidermal growth factor/neuregulin signaling pathwayAkt1 , Akt2 , Akt3 , Braf , Crk , Crkl , Gab1 , Grb2 , Hras , Jun , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Pak1 , Pak2 , Pak3 , Pak4 , Pak6 , Pak7 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Ptpn11 , Raf1 , Sos1 , Sos2 , Tgfa
erythropoietin signaling pathwayCrkl , Gab1 , Grb2 , Hras , Pik3r1 , Ptpn11 , Rap1a , Sos1
estrogen signaling pathwayCrebbp , Ep300
facilitative sugar transporter mediated glucose transport pathwaySlc2a1
FasL mediated signaling pathwayAkt1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3
Fc epsilon receptor mediated signaling pathwayAkt1 , Akt2 , Akt3 , Grb2 , Hras , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Rac1 , Raf1 , Sos1 , Sos2
Fc gamma receptor mediated signaling pathwayAkt1 , Akt2 , Akt3 , Cdc42 , Crk , Crkl , Map2k1 , Mapk1 , Mapk3 , Pak1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Rac1 , Raf1
fibroblast growth factor signaling pathwayAkt1 , Gab1 , Grb2 , Hgf , Jun , Mapk1 , Mapk3 , Pak4 , Pik3ca , Pik3r1 , Ptpn11 , Sos1
forkhead class A signaling pathwayAkt1 , Crebbp , Ep300 , Jun
fumaric aciduria pathwayFh , Sdhb , Sdhd
glioma pathwayAkt1 , Akt2 , Akt3 , Braf , Grb2 , Hras , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Pdgfa , Pdgfb , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Raf1 , Sos1 , Sos2 , Tgfa
Glut1 deficiency syndrome pathwaySlc2a1
glutamate signaling pathwayMapk1 , Mapk3
glypican signaling pathwayTgfb1 , Tgfb2 , Tgfb3 , Vegfa
gonadotropin-releasing hormone signaling pathwayCdc42 , Grb2 , Hras , Jun , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Raf1 , Sos1 , Sos2
granulocyte-macrophage colony-stimulating factor signaling pathwayGrb2 , Hras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Pik3ca , Pik3r1 , Ptpn11 , Raf1 , Sos1
Hedgehog signaling pathwayAkt1 , Crebbp , Map2k1 , Pik3ca , Pik3r1 , Tgfb2
hepatitis C pathwayAkt1 , Akt2 , Akt3 , Braf , Grb2 , Hras , Kras , Mapk1 , Mapk3 , Nras , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Raf1 , Sos1 , Sos2
histone modification pathwayCrebbp , Ep300 , Kdm5c , Pbrm1 , Setd2 , Uty
Huntington's disease pathwayCrebbp , Ep300 , Sdhb , Sdhd
hypertrophic cardiomyopathy pathwayTgfb1 , Tgfb2 , Tgfb3
hypoxia inducible factor pathwayAkt1 , Arnt , Arnt2 , Crebbp , Cul2 , Egln1 , Egln2 , Egln3 , Elob , Eloc , Ep300 , Epas1 , Ets1 , Hif1a , Jun , Rbx1 , Slc2a1 , Vegfa , Vhl
influenza A pathwayAkt1 , Akt2 , Akt3 , Crebbp , Ep300 , Jun , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Raf1
inositol metabolic pathwayPik3ca
inositol phosphate metabolic pathwayPik3ca , Pik3cb , Pik3cd
insulin responsive facilitative sugar transporter mediated glucose transport pathwayAkt1 , Akt2 , Crk , Pak1 , Rac1 , Rapgef1
insulin secretion pathwayCdc42
insulin signaling pathwayAkt1 , Akt2 , Akt3 , Braf , Crk , Crkl , Grb2 , Hras , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Ptpn11 , Raf1 , Rapgef1 , Sos1 , Sos2
insulin-like growth factor signaling pathwayAkt1 , Crk , Crkl , Grb2 , Hras , Pik3ca , Pik3r1 , Ptpn11 , Raf1 , Sos1
interleukin-1 signaling pathwayJun , Pik3ca , Pik3r1
interleukin-2 signaling pathwayGrb2 , Hras , Jun , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Pik3ca , Pik3r1 , Ptpn11 , Raf1 , Sos1
interleukin-23 signaling pathwayPik3ca , Pik3r1
interleukin-27 signaling pathwayTgfb1
interleukin-3 signaling pathwayGrb2 , Pik3ca , Pik3r1 , Ptpn11
interleukin-4 signaling pathwayAkt1 , Ets1 , Grb2 , Pik3ca , Pik3r1
interleukin-5 signaling pathwayGrb2 , Pik3ca , Pik3r1 , Ptpn11
interleukin-6 signaling pathwayAkt1 , Gab1 , Grb2 , Jun , Pik3ca , Pik3r1 , Ptpn11 , Rac1 , Sos1 , Sos2
Jak-Stat signaling pathwayAkt1 , Akt2 , Akt3 , Crebbp , Ep300 , Grb2 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Ptpn11 , Sos1 , Sos2
lactose biosynthetic pathwaySlc2a1
Leishmaniasis pathwayJun , Mapk1 , Mapk3 , Tgfb1 , Tgfb2 , Tgfb3
leptin system pathwayPtpn11
long term depressionBraf , Hras , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Raf1
long term potentiationBraf , Crebbp , Ep300 , Hras , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Raf1 , Rap1a , Rap1b
lysine degradation pathwaySetd2
malaria pathwayHgf , Met , Tgfb1 , Tgfb2 , Tgfb3
measles pathwayAkt1 , Akt2 , Akt3 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5
melanoma pathwayAkt1 , Akt2 , Akt3 , Braf , Hgf , Hras , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Met , Nras , Pdgfa , Pdgfb , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Raf1
mercaptopurine pharmacodynamics pathwayRac1
mercaptopurine pharmacokinetics pathwayRac1
mitochondrial complex II deficiency pathwayFh , Sdhb , Sdhd
mitogen activated protein kinase signaling pathwayAkt1 , Akt2 , Akt3 , Braf , Cdc42 , Crk , Crkl , Grb2 , Hras , Jun , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Pak1 , Pak2 , Pdgfa , Pdgfb , Rac1 , Raf1 , Rap1a , Rap1b , Sos1 , Sos2 , Tgfb1 , Tgfb2 , Tgfb3
mTOR signaling pathwayAkt1 , Akt2 , Akt3 , Braf , Flcn , Hif1a , Hras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Pgf , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Rac1 , Raf1 , Vegfa , Vegfb , Vegfc , Vegfd
myocarditis pathwayRac1
N-cadherin signaling pathwayCdc42 , Pik3ca , Pik3r1 , Ptpn11 , Rac1
neddylation pathwayCul2 , Rbx1
nerve growth factor signaling pathwaySos1
neurotrophic factor signaling pathwayAkt1 , Akt2 , Akt3 , Braf , Cdc42 , Crk , Crkl , Gab1 , Grb2 , Hras , Jun , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Ptpn11 , Rac1 , Raf1 , Rap1a , Rap1b , Rapgef1 , Sos1 , Sos2
NOD-like receptor signaling pathwayMapk1 , Mapk3
non-small cell lung carcinoma pathwayAkt1 , Akt2 , Akt3 , Braf , Grb2 , Hras , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Met , Nras , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Raf1 , Sos1 , Sos2 , Tgfa
Notch signaling pathwayCrebbp , Ep300
nuclear factor kappa B signaling pathwayPik3ca , Pik3r1 , Rbx1
nuclear factor, erythroid 2 like 2 signaling pathwayCrebbp , Rbx1
nucleotide excision repair pathwayRbx1
oxidative phosphorylation pathwaySdhb , Sdhd
p38 MAPK signaling pathwayCdc42 , Rac1
p53 signaling pathwayAkt1 , Crebbp , Ep300
pancreatic cancer pathwayAkt1 , Akt2 , Akt3 , Braf , Cdc42 , Kras , Map2k1 , Mapk1 , Mapk3 , Met , Pbrm1 , Pgf , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Rac1 , Raf1 , Tgfa , Tgfb1 , Tgfb2 , Tgfb3 , Vegfa , Vegfb , Vegfc , Vegfd
Parkinson's disease pathwaySdhb , Sdhd
phagocytosis pathwayRac1
phosphatidylinositol 3-kinase class I signaling pathwayHras , Nras , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Rac1 , Rap1a
phosphatidylinositol 3-kinase signaling pathwayPik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5
phosphatidylinositol 3-kinase-Akt signaling pathwayAkt1 , Akt2 , Akt3 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Raf1
phosphoinositide metabolic pathwayPik3ca , Pik3cd , Pik3r1
platelet-derived growth factor signaling pathwayBraf , Crk , Crkl , Gab1 , Grb2 , Hras , Jun , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Pak1 , Pdgfa , Pdgfb , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Ptpn11 , Rac1 , Raf1 , Rap1a , Rap1b , Sos1
prion disease pathwayMap2k1 , Map2k2 , Mapk1 , Mapk3
prostate cancer pathwayAkt1 , Akt2 , Akt3 , Braf , Crebbp , Ep300 , Grb2 , Hras , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Pdgfa , Pdgfb , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Raf1 , Sos1 , Sos2 , Tgfa
proteasome degradation pathway involving cullin-dependent ubiquitin ligasesCul2 , Rbx1 , Vhl
pyruvate dehydrogenase E2 deficiency pathwayFh , Sdhb , Sdhd
pyruvate dehydrogenase E3 deficiency pathwayFh , Sdhb , Sdhd
Ras family mediated signaling pathwaySos1
Reelin signaling pathwayAkt1 , Crkl , Pik3ca , Pik3r1 , Rap1a
renal cell carcinoma pathwayAkt1 , Akt2 , Akt3 , Arnt , Arnt2 , Braf , Cdc42 , Crebbp , Crk , Crkl , Cul2 , Egln1 , Egln2 , Egln3 , Elob , Eloc , Ep300 , Epas1 , Ets1 , Fh , Flcn , Gab1 , Grb2 , Hgf , Hif1a , Hras , Jun , Kdm5c , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Met , Nras , Pak1 , Pak2 , Pak3 , Pak4 , Pak6 , Pak7 , Pbrm1 , Pdgfa , Pdgfb , Pgf , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Ptpn11 , Rac1 , Raf1 , Rap1a , Rap1b , Rapgef1 , Rbx1 , Sdhb , Sdhd , Setd2 , Slc2a1 , Sos1 , Sos2 , Tgfa , Tgfb1 , Tgfb2 , Tgfb3 , Uty , Vegfa , Vegfb , Vegfc , Vegfd , Vhl
rheumatoid arthritis pathwayJun , Pgf , Tgfb1 , Tgfb2 , Tgfb3 , Vegfa , Vegfb
Rho/Rac/Cdc42 mediated signaling pathwayCdc42 , Crk , Jun , Pak1 , Rac1 , Rapgef1
RNA polymerase I transcription pathwayCrebbp
scatter factor/hepatocyte growth factor signaling pathwayCrkl , Gab1 , Grb2 , Hgf , Met , Pik3r1 , Ptpn11
small cell lung carcinoma pathwayAkt1 , Akt2 , Akt3 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5
somatostatin signaling pathwayPtpn11
sphingosine 1-phosphate signaling pathwayAkt1 , Akt3 , Cdc42 , Jun , Mapk1 , Mapk3 , Pak1 , Pdgfb , Rac1 , Vegfa
SWI/SNF family mediated chromatin remodeling pathwayPbrm1
syndecan signaling pathwayHgf , Hras , Mapk1 , Mapk3 , Rac1 , Tgfb1
T cell receptor signaling pathwayAkt1 , Akt2 , Akt3 , Cdc42 , Grb2 , Hras , Jun , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Pak1 , Pak2 , Pak3 , Pak4 , Pak6 , Pak7 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Raf1 , Sos1 , Sos2
the extracellular signal-regulated Raf/Mek/Erk signaling pathwayBraf , Hras , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Raf1
thyroid cancer pathwayBraf , Hras , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras
tioguanine pharmacodynamics pathwayRac1
Toll-like receptor signaling pathwayAkt1 , Akt2 , Akt3 , Jun , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Rac1
toxoplasmosis pathwayAkt1 , Akt2 , Akt3 , Mapk1 , Mapk3 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Tgfb1 , Tgfb2 , Tgfb3
Trail mediated signaling pathwayMapk1 , Mapk3 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3
transforming growth factor-beta Smad dependent signaling pathwayCrebbp , Grb2 , Sos1 , Tgfb1 , Tgfb2 , Tgfb3
transforming growth factor-beta superfamily mediated signaling pathwayCrebbp , Ep300 , Mapk1 , Mapk3 , Rbx1 , Tgfb1 , Tgfb2 , Tgfb3
tuberculosis pathwayAkt1 , Akt2 , Akt3 , Crebbp , Ep300 , Mapk1 , Mapk3 , Raf1 , Tgfb1 , Tgfb2 , Tgfb3
type 2 diabetes mellitus pathwayAkt2 , Mapk1 , Mapk3 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5
type II interferon signaling pathwayAkt1 , Crebbp , Crkl , Ep300 , Map2k1 , Mapk1 , Mapk3 , Pik3ca , Pik3r1 , Ptpn11 , Rap1a , Rap1b
ubiquitin/proteasome degradation pathwayCul2 , Elob , Eloc , Rbx1 , Vhl
urinary bladder cancer pathwayBraf , Hras , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Pgf , Raf1 , Vegfa , Vegfb , Vegfc , Vegfd
vascular endothelial growth factor signaling pathwayAkt1 , Akt2 , Akt3 , Braf , Cdc42 , Egln1 , Egln2 , Egln3 , Gab1 , Grb2 , Hif1a , Hras , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Pak2 , Pgf , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Ptpn11 , Rac1 , Raf1 , Vegfa , Vegfb , Vegfc , Vegfd
Wnt signaling pathwayCrebbp , Ep300 , Jun , Rac1 , Rbx1
Wnt signaling, canonical pathwayCrebbp
Wnt signaling, non-canonical pathwayCdc42 , Rac1
Wnt signaling, the planar cell polarity pathwayRac1
Phenotype Annotations Associated with Genes in the renal cell cancer pathway

References Associated with the renal cell cancer pathway:

Ontology Path Diagram:

paths to the root

Import into Pathway Studio: