RGD Reference Report - Plasma levels of TGF-beta1 in homeostasis of the inflammation in sickle cell disease. - Rat Genome Database

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Plasma levels of TGF-beta1 in homeostasis of the inflammation in sickle cell disease.

Authors: Torres Lde, S  Okumura, JV  Silva, DG  Belini Junior, E  Oliveira, RG  Mimura, KK  Lobo, CL  Oliani, SM  Bonini Domingos, CR 
Citation: Torres Lde S, etal., Cytokine. 2016 Apr;80:18-25. doi: 10.1016/j.cyto.2016.02.012. Epub 2016 Feb 27.
RGD ID: 11062147
Pubmed: PMID:26928604   (View Abstract at PubMed)
DOI: DOI:10.1016/j.cyto.2016.02.012   (Journal Full-text)

Sickle cell disease (SCD) represents a chronic inflammatory condition with complications triggered by the polymerization of hemoglobin S (Hb S), resulting in a series of cellular interactions mediated by inflammatory cytokines, as the transforming growth factor beta (TGF-beta), which plays an important role in inflammation resolution. This study assessed the relation between SCD inflammation and the plasma concentration of TGF-beta1, and also checked the influence of the presence of -509C/T polymorphism in TGFB1 gene on TGF-beta1 plasma values. The plasma levels of TGF-beta1 were quantified by ELISA in 115 patients with SCD (genotypes SS, SD-Los Angeles, Sbeta-thalassemia and SC) and in 58 individuals with no hemoglobinopathies (Hb AA), as the control group. The -509C/T polymorphism in TGFB1 gene was screened by PCR-RFLP. The correlation between TGF-beta1 plasma levels and the inflammation was based on its association with the count of platelets, total white blood cells (WBC) and neutrophils in the peripheral blood. Patients with SCD showed plasma levels of TGF-beta1 higher than the control group, especially the Hb SS genotype, followed by the group with Hb SD. Polymorphism investigation showed no interference in the values obtained for the cytokine in the groups evaluated. All SCD groups showed TGF-beta1 levels positively correlated to the platelets and WBC counts. The original data obtained in this study for SCD support the involvement of TGF-beta1 in regulating of the inflammatory response and suggest that this marker possibly may become a potential therapeutic target in the treatment of the disease.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
TGFB1Humansickle cell anemia  IEP protein:increased expression:plasma:RGD 
Tgfb1Ratsickle cell anemia  ISOTGFB1 (Homo sapiens)protein:increased expression:plasma:RGD 
Tgfb1Mousesickle cell anemia  ISOTGFB1 (Homo sapiens)protein:increased expression:plasma:RGD 

Objects Annotated

Genes (Rattus norvegicus)
Tgfb1  (transforming growth factor, beta 1)

Genes (Mus musculus)
Tgfb1  (transforming growth factor, beta 1)

Genes (Homo sapiens)
TGFB1  (transforming growth factor beta 1)


Additional Information