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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69051
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Tgfb1
Name: transforming growth factor, beta 1
Acc ID: CHEBI:46678
Term: amosite asbestos
Definition: null
Chemical ID: MESH:D017639
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tgfb1decreases expressionEXP 6480464CTDAsbestos, Amosite results in decreased expression of TGFB1 mRNAPMID:21797767
Tgfb1increases expressionEXP 6480464CTDAsbestos, Amosite results in increased expression of TGFB1 mRNAPMID:11306436 PMID:12475806
Tgfb1multiple interactionsEXP 6480464CTD2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Asbestos, Amosite results in increased expression of TGFB1 mRNA]; Deferoxamine inhibits the reaction [Asbestos, Amosite results in increased expression of TGFB1 mRNA]; Iron promotes the reaction [Asbestos, Amosite results in increased expression of TGFB1 mRNA]; tetramethylthiourea inhibits the reaction [Asbestos, Amosite results in increased expression of TGFB1 mRNA]PMID:11306436 PMID:12475806
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