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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69051
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Tgfb1
Name: transforming growth factor, beta 1
Acc ID: CHEBI:2038
Term: 5-azacytidine
Definition: An N-glycosyl-1,3,5-triazine that is 4-amino-1,3,5-triazin-2(1H)-one substituted by a beta-D-ribofuranosyl residue via an N-glycosidic linkage. An antineoplastic agent, it is used in the treatment of myeloid leukaemia.
Chemical ID: MESH:D001374
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tgfb1multiple interactionsISORGD:690956480464CTDAzacitidine inhibits the reaction [TGFB1 protein results in decreased expression of PTEN mRNA] Azacitidine inhibits the reaction [TGFB1 protein results in decreased expression of PTEN protein] Azacitidine inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 mRNA] Azacitidine inhibits the reaction [TGFB1 protein results in increased expression of COL1A1 mRNA] Azacitidine inhibits the reaction [TGFB1 protein results in increased expression of COL1A1 protein] Azacitidine inhibits the reaction [TGFB1 protein results in increased methylation of PTEN promoter] Azacitidine inhibits the reaction [TGFB1 protein results in increased phosphorylation of AKT1 protein]

PMID:22841775
Tgfb1multiple interactionsISORGD:690966480464CTD[Azacitidine co-treated with TGFB1 protein] results in increased expression of FOXP3 protein

PMID:18493985
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