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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69051
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Tgfb1
Name: transforming growth factor, beta 1
Acc ID: CHEBI:17226
Term: rosmarinic acid
Definition: The 1-carboxy-2-(2,4-dihydroxyphenyl)ethyl ester of trans-caffeic acid.
Chemical ID: MESH:C041376
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tgfb1decreases expressionEXP 6480464CTDrosmarinic acid results in decreased expression of TGFB1 protein

PMID:28789951
Tgfb1multiple interactionsEXP 6480464CTDrosmarinic acid inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein], rosmarinic acid inhibits the reaction [TGFB1 protein results in increased expression of CCN2 protein], rosmarinic acid inhibits the reaction [TGFB1 protein results in increased expression of CCND1 protein], rosmarinic acid inhibits the reaction [TGFB1 protein results in increased expression of COL1A1 mRNA], rosmarinic acid inhibits the reaction [TGFB1 protein results in increased expression of COL3A1 mRNA], rosmarinic acid inhibits the reaction [TGFB1 protein results in increased expression of DES protein], rosmarinic acid inhibits the reaction [TGFB1 protein results in increased expression of VIM protein]

PMID:28789951
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.