Il10 (interleukin 10) - Rat Genome Database
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Gene: Il10 (interleukin 10) Mus musculus
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Symbol: Il10
Name: interleukin 10
RGD ID: 10785
MGI Page MGI
Description: Exhibits cytokine activity. Involved in several processes, including negative regulation of cell death; negative regulation of cytokine production; and response to bacterium. Localizes to extracellular space. Is expressed in colon; liver; thymus; and thymus primordium. Used to study inflammatory bowel disease. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); autoimmune disease (multiple); eye disease (multiple); gastrointestinal system cancer (multiple); and hematologic cancer (multiple). Orthologous to human IL10 (interleukin 10).
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: CSIF; cytokine synthesis inhibitory factor; If2a; IL-; Il-10; interferon 2a; interleukin-10
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391130,947,459 - 130,952,707 (+)NCBIGRCm39mm39
GRCm381131,019,845 - 131,024,970 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1131,019,845 - 131,024,974 (+)EnsemblGRCm38mm10GRCm38
MGSCv371132,916,422 - 132,921,547 (+)NCBIGRCm37mm9NCBIm37
MGSCv361132,847,393 - 132,852,516 (+)NCBImm8
Celera1133,642,456 - 133,647,581 (+)NCBICelera
Cytogenetic Map1E4NCBI
cM Map156.89NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
abdominal aortic aneurysm  (ISO)
Actinic Cheilitis  (ISO)
acute kidney failure  (ISO)
Acute Liver Failure  (ISO)
Acute Lung Injury  (ISO)
acute lymphoblastic leukemia  (ISO)
acute myeloid leukemia  (ISO)
acute pancreatitis  (ISO)
adult respiratory distress syndrome  (ISO)
adult T-cell leukemia  (ISO)
aggressive periodontitis  (ISO)
Airway Obstruction  (ISO)
allergic conjunctivitis  (IMP,ISO)
allergic contact dermatitis  (IDA,ISO)
allergic rhinitis  (IDA,ISO)
Alveolar Bone Loss  (ISO)
Alzheimer's disease  (IMP,ISO)
anemia  (ISO)
Animal Disease Models  (ISO)
anogenital venereal wart  (ISO)
anti-basement membrane glomerulonephritis  (ISO)
aphthous stomatitis  (ISO)
appendicitis  (ISO)
arteriosclerosis  (IAGP,ISO)
Asthenopia  (IEP)
asthma  (IEP,IMP,ISO)
atopic dermatitis  (IDA,ISO)
autistic disorder  (ISO)
autoimmune hemolytic anemia  (IMP)
autoimmune hepatitis  (ISO)
autoimmune thrombocytopenic purpura  (ISO)
B-Cell Chronic Lymphocytic Leukemia  (ISO)
bacterial infectious disease  (ISO)
bacterial pneumonia  (IEP)
Behcet's disease  (IDA,ISO)
Brain Injuries  (ISO)
Breast Neoplasms  (ISO)
Bronchial Hyperreactivity  (ISO)
bronchus carcinoma  (ISO)
Burns  (ISO)
carotid artery disease  (ISO)
carotid stenosis  (ISO)
celiac disease  (ISO)
central nervous system lymphoma  (ISO)
cervical cancer  (ISO)
Chagas Cardiomyopathy  (ISO)
choroid disease  (ISO)
Choroidal Neovascularization  (IMP)
Chronic Bronchitis  (ISO)
Chronic Hepatitis C  (ISO)
chronic myeloid leukemia  (ISO)
Chronic Periodontitis  (ISO)
colitis  (IMP,ISO)
colon cancer  (ISO)
common cold  (ISO)
congestive heart failure  (IEP,ISO)
coronary artery disease  (ISO)
Coronavirus infectious disease  (IEP)
COVID-19  (ISO)
Crohn's disease  (IMP,ISO)
cutaneous leishmaniasis  (ISO)
cytomegalovirus retinitis  (IEP)
decubitus ulcer  (ISO)
diabetes mellitus  (ISO)
Diabetic Cardiomyopathies  (ISO)
Diabetic Nephropathies  (ISO)
diabetic retinopathy  (ISO)
diffuse scleroderma  (ISO)
dilated cardiomyopathy  (ISO)
disseminated intravascular coagulation  (ISO)
drug allergy  (ISO)
Drug-Related Side Effects and Adverse Reactions  (ISO)
dry eye syndrome  (ISO)
Dysbiosis  (ISO)
Dyspepsia  (ISO)
Eales Disease  (ISO)
endometrial cancer  (ISO)
endometriosis  (ISO)
Endotoxemia  (IEP)
Entamoebiasis  (ISO)
Enterocolitis  (ISO)
Enterovirus Infections  (ISO)
Experimental Arthritis  (ISO)
Experimental Autoimmune Encephalomyelitis  (ISO)
Experimental Autoimmune Myocarditis  (ISO)
Experimental Autoimmune Uveitis  (IEP,IMP)
Experimental Autoimmune Uveoretinitis  (IDA,IEP,IMP,ISO)
Experimental Colitis  (IMP,ISO)
Experimental Diabetes Mellitus  (IMP,ISO)
Experimental Liver Cirrhosis  (ISO)
Experimental Pancreatitis, Acute  (ISO)
Eye Burns  (ISO)
factor VIII deficiency  (ISO)
Fanconi anemia  (ISO)
fatty liver disease  (ISO)
Femoral Fractures  (ISO)
gallbladder carcinoma  (ISO)
gastric dilatation  (IEP)
Gastro-Enteropancreatic Neuroendocrine Tumor  (ISO)
Genetic Predisposition to Disease  (ISO)
gestational diabetes  (ISO)
glomerulonephritis  (ISO)
glucosephosphate dehydrogenase deficiency  (ISO)
Graft vs Host Disease  (ISO)
granulomatosis with polyangiitis  (ISO)
Graves Ophthalmopathy  (ISO)
Graves' disease  (ISO)
Hearing Loss  (IMP,ISO)
Heat Stroke  (ISO)
Hemorrhagic Shock  (ISO)
Heparin-induced Thrombocytopenia  (ISO)
hepatitis B  (ISO)
hepatitis C  (ISO)
hepatocellular carcinoma  (ISO)
herpes simplex virus keratitis  (IDA)
herpes zoster  (ISO)
high grade glioma  (ISO)
Hodgkin's lymphoma  (ISO)
human immunodeficiency virus infectious disease  (ISO)
Human Influenza  (IMP)
Human Viral Hepatitis  (ISO)
Hyperalgesia  (ISO)
hypertension  (ISO)
hyperthyroidism  (IMP,ISO)
hypothyroidism  (ISO)
ileitis  (ISO)
Immediate Hypersensitivity  (ISO)
Inflammation  (IMP,ISO)
inflammatory bowel disease  (IEA,IEP,IMP,ISO)
intermediate uveitis  (ISO)
intestinal obstruction  (ISO)
irritable bowel syndrome  (ISO)
Kidney Reperfusion Injury  (IEP,ISO)
leishmaniasis  (ISO)
lip cancer  (ISO)
liver benign neoplasm  (ISO)
liver cancer  (ISO)
liver carcinoma  (ISO)
liver cirrhosis  (ISO)
Liver Reperfusion Injury  (ISO)
lung disease  (ISO)
Lung Neoplasms  (ISO)
lung non-small cell carcinoma  (ISO)
major depressive disorder  (ISO)
Malignant Pleural Effusions  (IMP)
Mammary Neoplasms, Experimental  (ISO)
Middle East respiratory syndrome  (HEP)
mitral valve stenosis  (ISO)
mucositis  (ISO)
multiple myeloma  (ISO)
Multiple Organ Failure  (ISO)
multiple sclerosis  (ISO)
Murine Acquired Immunodeficiency Syndrome  (IEP)
myocardial infarction  (ISO)
Myocardial Reperfusion Injury  (ISO)
myocarditis  (IDA,ISO)
Nasal Polyps  (ISO)
Neoplasm Metastasis  (ISO)
Neuralgia  (ISO)
non-alcoholic fatty liver disease  (ISO)
non-alcoholic steatohepatitis  (ISO)
obesity  (ISO)
obstructive sleep apnea  (ISO)
occupational dermatitis  (ISO)
Ocular Toxoplasmosis  (IMP)
ocular tuberculosis  (ISO)
open-angle glaucoma  (ISO)
oral squamous cell carcinoma  (ISO)
otitis media  (IMP,ISO)
ovarian cancer  (ISO)
pancreatic cancer  (ISO)
pancreatitis  (ISO)
panuveitis  (ISO)
pericardial effusion  (ISO)
perinatal necrotizing enterocolitis  (IMP,ISO)
periodontitis  (IEP,ISO)
plasmacytoma  (IMP)
pleurisy  (ISO)
pneumonia  (ISO)
postpartum depression  (ISO)
Pregnancy-associated Malaria  (ISO)
primary biliary cholangitis  (ISO)
Primary Graft Dysfunction  (ISO)
Prostatic Neoplasms  (ISO)
prostatitis  (ISO)
Pseudomonas Aeruginosa Keratitis  (IDA)
psoriasis  (ISO)
pulmonary eosinophilia  (ISO)
pulmonary hypertension  (ISO)
Radiation Injuries, Experimental  (ISO)
Reperfusion Injury  (ISO)
respiratory allergy  (IDA)
respiratory syncytial virus infectious disease  (ISO)
retinal artery occlusion  (ISO)
retinal disease  (IMP,ISO)
retinopathy of prematurity  (ISO)
Retroviridae Infections  (IMP)
rheumatic heart disease  (ISO)
rheumatoid arthritis  (ISO)
Rhinosinusitis  (ISO)
schizophrenia  (ISO)
sciatic neuropathy  (ISO)
Seasonal Allergic Rhinitis  (ISO)
Sepsis  (IDA,IEP,ISO)
severe acute respiratory syndrome  (HEP,ISO)
shigellosis  (IEP)
Shwartzman phenomenon  (IMP)
sickle cell anemia  (IEP)
Sjogren's syndrome  (ISO)
skin disease  (ISO)
Spinal Cord Injuries  (ISO)
Splenomegaly  (IMP)
Staphylococcal Infections  (ISO)
Staphylococcal Pneumonia  (IEP)
stomach cancer  (ISO)
Stroke  (IAGP,ISO)
systemic lupus erythematosus  (ISO)
thrombocytopenia  (ISO)
thrombosis  (IAGP)
thyrotoxicosis  (ISO)
tongue squamous cell carcinoma  (ISO)
toxic encephalopathy  (ISO)
toxic shock syndrome  (IAGP,IEP,IMP,ISO)
Toxoplasma Chorioretinitis  (ISO)
trachoma  (ISO)
transient cerebral ischemia  (ISO)
Transplant Rejection  (IDA,ISO)
trichinosis  (IMP)
type 1 diabetes mellitus  (ISO)
type 2 diabetes mellitus  (ISO)
ulcerative colitis  (ISO)
uveitis  (ISO)
vasculitis  (ISO)
Venous Thrombosis  (ISO)
Ventilator-Induced Lung Injury  (ISO)
viral pneumonia  (IEP)
visceral leishmaniasis  (ISO)
Waldenstroem's macroglobulinemia  (ISO)
Weight Loss  (ISO)
Wilson disease  (ISO)
Wounds and Injuries  (ISO)
Wounds, Penetrating  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-alpha-tocopherol  (ISO)
(+)-catechin  (ISO)
(+)-pilocarpine  (ISO)
(+)-syringaresinol beta-D-glucoside  (EXP)
(+)-Tetrandrine  (EXP)
(-)-citrinin  (EXP)
(-)-epigallocatechin 3-gallate  (ISO)
(4-oxo-3-\{[5-(trifluoromethyl)-1,3-benzothiazol-2-yl]methyl\}-3,4-dihydrophthalazin-1-yl)acetic acid  (EXP)
(R)-adrenaline  (ISO)
(R)-carnitine  (ISO)
(R)-lipoic acid  (ISO)
(S)-amphetamine  (EXP)
(S)-nicotine  (EXP,ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (ISO)
1,2-dimethylhydrazine  (EXP)
1,3,5-trinitrobenzene  (EXP)
1,4-benzoquinone  (ISO)
1,4-phenylenediamine  (EXP)
1-chloro-2,4,6-trinitrobenzene  (EXP)
1-chloro-2,4-dinitrobenzene  (EXP)
1-fluoro-2,4-dinitrobenzene  (EXP)
1-naphthyl isothiocyanate  (EXP,ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,4,6-trinitrobenzenesulfonic acid  (EXP,ISO)
2,6-di-tert-butyl-4-methylphenol  (EXP)
2-acetamidofluorene  (ISO)
2-amino-2-deoxy-D-galactopyranose  (EXP,ISO)
2-chloroethanol  (EXP)
2-naphthylamine  (ISO)
2-tert-butylhydroquinone  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP,ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3-[3-(tert-butylsulfanyl)-1-(4-chlorobenzyl)-5-(propan-2-yl)-1H-indol-2-yl]-2,2-dimethylpropanoic acid  (EXP)
3-chloropropane-1,2-diol  (ISO)
3-phenylprop-2-enal  (EXP)
4'-hydroxydiclofenac  (ISO)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (EXP)
4-chloro-m-cresol  (ISO)
4-hydroxynon-2-enal  (EXP)
4-methylhistamine  (ISO)
4-nitroquinoline N-oxide  (EXP)
4-nonylphenol  (ISO)
4-octylphenol  (ISO)
4-tolyl isocyanate  (EXP)
5-(1,4-diazepane-1-sulfonyl)isoquinoline  (ISO)
5-[3-(tert-butylamino)-2-hydroxypropoxy]-1,2,3,4-tetrahydronaphthalene-2,3-diol  (EXP)
5-aminoimidazole-4-carboxamide  (ISO)
5-fluorouracil  (EXP)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (EXP)
6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide  (ISO)
6alpha-methylprednisolone  (EXP)
7,12-dimethyltetraphene  (ISO)
7-ketocholesterol  (ISO)
acetaldehyde  (ISO)
acetic acid  (ISO)
acetylsalicylic acid  (ISO)
acrolein  (ISO)
actinomycin D  (EXP)
adapalene  (ISO)
adenosine  (EXP)
adenosine 5'-[gamma-thio]triphosphate  (EXP)
aflatoxin B1  (EXP,ISO)
aflatoxin B2  (EXP)
Aflatoxin G1  (EXP)
agathisflavone  (ISO)
albendazole  (ISO)
albuterol  (ISO)
all-trans-retinoic acid  (ISO)
all-trans-retinyl palmitate  (ISO)
alloxan  (EXP)
alpha-galactosylceramide  (EXP)
alpha-naphthoflavone  (EXP,ISO)
aluminium oxide  (ISO)
amitrole  (ISO)
ammonium chloride  (ISO)
Ammothamnine  (ISO)
amphibole asbestos  (EXP)
amphotericin B  (ISO)
anthocyanin  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (EXP)
apigenin  (EXP,ISO)
arsane  (EXP,ISO)
arsenic atom  (EXP,ISO)
arsenous acid  (EXP)
asbestos  (ISO)
asperentin  (EXP)
atrazine  (ISO)
beclomethasone  (ISO)
benzalkonium chloride  (EXP,ISO)
benzene  (ISO)
benzene-1,2,4-triol  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzocaine  (EXP)
berberine  (EXP,ISO)
Bergenin  (ISO)
beta-D-glucan  (ISO)
biliverdin  (EXP)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (EXP)
bisoprolol  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol A diglycidyl ether  (ISO)
bisphenol F  (EXP)
bleomycin A2  (EXP)
boric acid  (ISO)
boron atom  (ISO)
bortezomib  (ISO)
BQ 123  (EXP)
bryostatin 1  (ISO)
bucladesine  (EXP,ISO)
butan-1-ol  (ISO)
C60 fullerene  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
cadmium selenide  (ISO)
caffeine  (ISO)
calciol  (ISO)
calcitriol  (ISO)
capsaicin  (EXP,ISO)
carbachol  (EXP)
carbamate ester  (ISO)
carbon monoxide  (EXP,ISO)
carbon nanotube  (EXP,ISO)
carnosine  (EXP)
carrageenan  (EXP,ISO)
carvedilol  (ISO)
catechol  (ISO)
cefotaxime  (ISO)
ceftazidime pentahydrate  (ISO)
cefuroxime  (ISO)
celastrol  (EXP)
celecoxib  (EXP,ISO)
cerium trichloride  (EXP)
ceruletide  (ISO)
CGS-21680  (ISO)
chenodeoxycholic acid  (EXP)
chitosan  (ISO)
chloroethene  (EXP)
chloroquine  (EXP)
chlorpyrifos  (EXP,ISO)
choline  (EXP)
chromium atom  (ISO)
chrysin  (EXP,ISO)
ciprofloxacin  (ISO)
cis-caffeic acid  (EXP)
cisplatin  (EXP,ISO)
citronellol  (ISO)
clenbuterol  (ISO)
clodronic acid  (EXP)
clonidine  (ISO)
clonidine (amino form)  (ISO)
clonidine (imino form)  (ISO)
clozapine  (ISO)
cobalt dichloride  (EXP,ISO)
cocaine  (ISO)
colforsin daropate hydrochloride  (EXP)
copper atom  (EXP)
copper(0)  (EXP)
copper(II) sulfate  (ISO)
cortisol  (ISO)
costunolide  (EXP)
coumarins  (EXP)
crocidolite asbestos  (EXP,ISO)
crocin-1  (ISO)
crotonaldehyde  (ISO)
curcumin  (EXP,ISO)
cycloheximide  (EXP,ISO)
Cyclopamine  (ISO)
cyclophosphamide  (EXP,ISO)
cyclosporin A  (EXP,ISO)
cyhalothrin  (ISO)
cypermethrin  (ISO)
D-penicillamine  (ISO)
danazol  (ISO)
dantrolene  (ISO)
DAPT  (ISO)
decabromodiphenyl ether  (EXP)
Deguelin  (ISO)
deoxycholic acid  (EXP)
deoxynivalenol  (EXP)
desferrioxamine B  (ISO)
dexamethasone  (EXP,ISO)
dextran  (EXP)
dextran sulfate  (EXP,ISO)
dextromethorphan  (EXP)
diallyl trisulfide  (EXP)
diarsenic trioxide  (EXP)