Il10 (interleukin 10) - Rat Genome Database

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Gene: Il10 (interleukin 10) Mus musculus
Analyze
Symbol: Il10
Name: interleukin 10
RGD ID: 10785
MGI Page MGI
Description: Enables cytokine activity. Involved in several processes, including negative regulation of apoptotic process; negative regulation of vascular associated smooth muscle cell proliferation; and positive regulation of sprouting angiogenesis. Acts upstream of or within several processes, including cellular response to hepatocyte growth factor stimulus; negative regulation of cytokine production; and response to bacterium. Located in extracellular space. Is expressed in colon; liver; mandible; thymus; and thymus primordium. Used to study inflammatory bowel disease. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); autoimmune disease (multiple); eye disease (multiple); gastrointestinal system cancer (multiple); and hematologic cancer (multiple). Orthologous to human IL10 (interleukin 10).
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: CSIF; cytokine synthesis inhibitory factor; If2a; IL-; Il-10; interferon 2a; interleukin-10
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391130,947,459 - 130,952,707 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1130,947,582 - 130,952,711 (+)EnsemblGRCm39 Ensembl
GRCm381131,019,845 - 131,024,970 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1131,019,845 - 131,024,974 (+)EnsemblGRCm38mm10GRCm38
MGSCv371132,916,422 - 132,921,547 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361132,847,393 - 132,852,516 (+)NCBIMGSCv36mm8
Celera1133,642,456 - 133,647,581 (+)NCBICelera
Cytogenetic Map1E4NCBI
cM Map156.89NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
abdominal aortic aneurysm  (ISO)
Actinic Cheilitis  (ISO)
Acute Experimental Pancreatitis  (ISO)
acute kidney failure  (ISO)
Acute Liver Failure  (ISO)
Acute Lung Injury  (ISO)
acute lymphoblastic leukemia  (ISO)
acute myeloid leukemia  (ISO)
acute myocardial infarction  (ISO)
acute pancreatitis  (ISO)
adult respiratory distress syndrome  (ISO)
adult T-cell leukemia/lymphoma  (ISO)
aggressive periodontitis  (ISO)
Airway Obstruction  (ISO)
alcohol use disorder  (ISO)
allergic conjunctivitis  (IMP,ISO)
allergic contact dermatitis  (IDA,ISO)
allergic rhinitis  (IDA,ISO)
Alveolar Bone Loss  (ISO)
Alzheimer's disease  (IMP,ISO)
anemia  (ISO)
Animal Disease Models  (ISO)
anogenital venereal wart  (ISO)
anti-basement membrane glomerulonephritis  (ISO)
aphthous stomatitis  (ISO)
appendicitis  (ISO)
arteriosclerosis  (IAGP,ISO)
Asthenopia  (IEP)
asthma  (IEP,IMP,ISO)
atherosclerosis  (IDA)
atopic dermatitis  (IDA,ISO)
autistic disorder  (ISO)
autoimmune hemolytic anemia  (IMP)
autoimmune hepatitis  (ISO)
autoimmune thrombocytopenic purpura  (ISO)
B-Cell Chronic Lymphocytic Leukemia  (ISO)
bacterial infectious disease  (ISO)
bacterial pneumonia  (IEP)
Behcet's disease  (IDA,ISO)
Brain Injuries  (ISO)
Breast Neoplasms  (ISO)
Bronchial Hyperreactivity  (ISO)
bronchus carcinoma  (ISO)
Burns  (ISO)
carotid artery disease  (ISO)
carotid stenosis  (ISO)
celiac disease  (ISO)
central nervous system lymphoma  (ISO)
cerebral infarction  (IEP)
cervical cancer  (ISO)
Chagas Cardiomyopathy  (ISO)
Chemically-Induced Disorders  (ISO)
cholangiocarcinoma  (ISO)
choroid disease  (ISO)
Choroidal Neovascularization  (IMP)
Chronic Bronchitis  (ISO)
Chronic Hepatitis C  (ISO)
chronic myeloid leukemia  (ISO)
Chronic Periodontitis  (ISO)
colitis  (IMP,ISO)
colon cancer  (ISO)
common cold  (ISO)
common variable immunodeficiency 7  (ISO)
congestive heart failure  (ISO)
coronary artery disease  (ISO)
Coronavirus infectious disease  (IEP)
COVID-19  (ISO)
Crohn's disease  (IMP,ISO)
cutaneous leishmaniasis  (ISO)
cytomegalovirus retinitis  (IEP)
decubitus ulcer  (ISO)
diabetes mellitus  (ISO)
Diabetic Cardiomyopathies  (ISO)
Diabetic Nephropathies  (ISO)
diabetic retinopathy  (ISO)
diffuse scleroderma  (ISO)
dilated cardiomyopathy  (ISO)
disseminated intravascular coagulation  (ISO)
drug allergy  (ISO)
Drug-Related Side Effects and Adverse Reactions  (ISO)
dry eye syndrome  (ISO)
Dysbiosis  (ISO)
Dyspepsia  (ISO)
Eales Disease  (ISO)
endometrial cancer  (ISO)
endometriosis  (ISO)
Endotoxemia  (IEP)
Entamoebiasis  (ISO)
Enterocolitis  (ISO)
Enterovirus Infections  (ISO)
esophageal cancer  (ISO)
Experimental Arthritis  (ISO)
Experimental Autoimmune Encephalomyelitis  (ISO)
Experimental Autoimmune Myocarditis  (ISO)
Experimental Autoimmune Uveitis  (IEP,IMP,ISO)
Experimental Autoimmune Uveoretinitis  (IDA,IEP,IMP,ISO)
Experimental Colitis  (IMP,ISO)
Experimental Diabetes Mellitus  (IMP,ISO)
Experimental Liver Cirrhosis  (ISO)
Experimental Mammary Neoplasms  (ISO)
Experimental Radiation Injuries  (ISO)
Eye Burns  (ISO)
factor VIII deficiency  (ISO)
familial adult myoclonic epilepsy 5  (ISO)
Fanconi anemia  (ISO)
Femoral Fractures  (ISO)
gallbladder carcinoma  (ISO)
gastric dilatation  (IEP)
Gastro-Enteropancreatic Neuroendocrine Tumor  (ISO)
gastrointestinal stromal tumor  (ISO)
genetic disease  (ISO)
Genetic Predisposition to Disease  (ISO)
gestational diabetes  (ISO)
glomerulonephritis  (ISO)
glucosephosphate dehydrogenase deficiency  (ISO)
graft-versus-host disease  (ISO)
granulomatosis with polyangiitis  (ISO)
Graves ophthalmopathy  (ISO)
Graves' disease  (ISO)
Hearing Loss  (IMP,ISO)
Heat Stroke  (ISO)
Hemorrhagic Shock  (ISO)
Heparin-induced Thrombocytopenia  (ISO)
hepatitis B  (ISO)
hepatitis C  (ISO)
hepatocellular carcinoma  (ISO)
herpes simplex virus keratitis  (IDA)
herpes zoster  (ISO)
high grade glioma  (ISO)
Hodgkin's lymphoma  (ISO)
human immunodeficiency virus infectious disease  (ISO)
Human Influenza  (IMP)
Human Viral Hepatitis  (ISO)
Hyperalgesia  (ISO)
hypertension  (ISO)
hyperthyroidism  (IMP,ISO)
Hypokalemic Periodic Paralysis, Type 1  (ISO)
hypothyroidism  (ISO)
ileitis  (ISO)
Immediate Hypersensitivity  (ISO)
Inflammation  (IMP,ISO)
inflammatory bowel disease  (IAGP,IEP,IMP,ISO)
intermediate uveitis  (ISO)
intestinal obstruction  (ISO)
irritable bowel syndrome  (ISO)
Kidney Reperfusion Injury  (IEP,ISO)
leishmaniasis  (ISO)
leprosy  (ISO)
lip cancer  (ISO)
liver benign neoplasm  (ISO)
liver cancer  (ISO)
liver carcinoma  (ISO)
liver cirrhosis  (ISO)
Liver Reperfusion Injury  (ISO)
lung disease  (ISO)
Lung Neoplasms  (ISO)
lung non-small cell carcinoma  (ISO)
lymphoplasmacytic lymphoma  (ISO)
major depressive disorder  (ISO)
Malignant Pleural Effusions  (IMP)
metabolic dysfunction-associated steatohepatitis  (ISO)
metabolic dysfunction-associated steatotic liver disease  (ISO)
middle cerebral artery infarction  (IEP)
Middle East respiratory syndrome  (HEP)
mitral valve stenosis  (ISO)
mucositis  (ISO)
multiple myeloma  (ISO)
Multiple Organ Failure  (ISO)
multiple sclerosis  (ISO)
Murine Acquired Immunodeficiency Syndrome  (IEP)
myocardial infarction  (ISO)
Myocardial Reperfusion Injury  (ISO)
myocarditis  (IDA,ISO)
Nasal Polyps  (ISO)
Neoplasm Metastasis  (ISO)
Neuralgia  (ISO)
obesity  (ISO)
obstructive sleep apnea  (ISO)
occupational dermatitis  (ISO)
Ocular Toxoplasmosis  (IMP)
ocular tuberculosis  (ISO)
open-angle glaucoma  (ISO)
oral squamous cell carcinoma  (ISO)
otitis media  (IMP,ISO)
ovarian cancer  (ISO)
pancreatic cancer  (ISO)
pancreatitis  (ISO)
panuveitis  (ISO)
parathyroid carcinoma  (ISO)
Penetrating Wounds  (ISO)
pericardial effusion  (ISO)
perinatal necrotizing enterocolitis  (IMP,ISO)
periodontitis  (IEP,ISO)
Plaque, Atherosclerotic  (IEP)
plasmacytoma  (IMP)
pleurisy  (ISO)
pneumonia  (ISO)
postpartum depression  (ISO)
Pregnancy-associated Malaria  (ISO)
primary biliary cholangitis  (ISO)
Primary Graft Dysfunction  (ISO)
Prostatic Neoplasms  (ISO)
prostatitis  (ISO)
Pseudomonas Aeruginosa Keratitis  (IDA)
psoriasis  (ISO)
pulmonary eosinophilia  (ISO)
pulmonary hypertension  (ISO)
Reperfusion Injury  (ISO)
respiratory allergy  (IDA)
respiratory syncytial virus infectious disease  (ISO)
retinal artery occlusion  (ISO)
retinal disease  (IMP,ISO)
retinopathy of prematurity  (ISO)
Retroviridae Infections  (IMP)
rheumatic heart disease  (ISO)
rheumatoid arthritis  (ISO)
Rhinosinusitis  (ISO)
schizophrenia  (ISO)
sciatic neuropathy  (ISO)
Seasonal Allergic Rhinitis  (ISO)
Sepsis  (IDA,IEP,ISO)
severe acute respiratory syndrome  (HEP,ISO)
shigellosis  (IEP)
Shwartzman phenomenon  (IMP)
sickle cell anemia  (IEP)
Sjogren's syndrome  (ISO)
skin disease  (ISO)
Spinal Cord Injuries  (ISO)
Splenomegaly  (IMP)
Staphylococcal Infections  (ISO)
Staphylococcal Pneumonia  (IEP)
steatotic liver disease  (ISO)
stomach cancer  (ISO)
Stroke  (IAGP,ISO)
systemic lupus erythematosus  (ISO)
thrombocytopenia  (ISO)
thrombosis  (IAGP)
thyrotoxicosis  (ISO)
tongue squamous cell carcinoma  (ISO)
toxic encephalopathy  (ISO)
toxic shock syndrome  (IAGP,IEP,IMP,ISO)
Toxoplasma Chorioretinitis  (ISO)
trachoma  (ISO)
transient cerebral ischemia  (ISO)
Transplant Rejection  (IDA,ISO)
trichinosis  (IMP)
type 1 diabetes mellitus  (ISO)
type 2 diabetes mellitus  (ISO)
ulcerative colitis  (ISO)
uveitis  (ISO)
vasculitis  (ISO)
Venous Thrombosis  (ISO)
Ventilator-Induced Lung Injury  (ISO)
viral pneumonia  (IEP)
visceral leishmaniasis  (ISO)
Weight Loss  (ISO)
Wilson disease  (ISO)
Wounds and Injuries  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (EXP,ISO)
(+)-pilocarpine  (ISO)
(+)-syringaresinol beta-D-glucoside  (EXP)
(+)-Tetrandrine  (EXP)
(-)-citrinin  (EXP)
(-)-epigallocatechin 3-gallate  (EXP,ISO)
(2E,4E)-hexa-2,4-dienoic acid  (ISO)
(4-oxo-3-\{[5-(trifluoromethyl)-1,3-benzothiazol-2-yl]methyl\}-3,4-dihydrophthalazin-1-yl)acetic acid  (EXP)
(R)-adrenaline  (ISO)
(R)-carnitine  (ISO)
(R)-lipoic acid  (ISO)
(R,R,R)-alpha-tocopherol  (ISO)
(S)-amphetamine  (EXP)
(S)-colchicine  (ISO)
(S)-nicotine  (EXP,ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (ISO)
1,2-dimethylhydrazine  (EXP)
1,3,5-trinitrobenzene  (EXP)
1,4-benzoquinone  (ISO)
1,4-phenylenediamine  (EXP)
1-[(2,3,4-trimethoxyphenyl)methyl]piperazine  (EXP)
1-chloro-2,4,6-trinitrobenzene  (EXP)
1-chloro-2,4-dinitrobenzene  (EXP)
1-fluoro-2,4-dinitrobenzene  (EXP)
1-naphthyl isothiocyanate  (EXP,ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP,ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,4,6-trinitrobenzenesulfonic acid  (EXP,ISO)
2,4-D  (EXP)
2,5-dihydroxybenzoic acid  (EXP)
2,6-di-tert-butyl-4-methylphenol  (EXP)
2-acetamidofluorene  (ISO)
2-amino-2-deoxy-D-galactopyranose  (EXP,ISO)
2-chloroethanol  (EXP)
2-naphthylamine  (ISO)
2-tert-butylhydroquinone  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP,ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,3',5-triiodo-L-thyronine  (ISO)
3,4-dihydroxybenzoic acid  (ISO)
3-[3-(tert-butylsulfanyl)-1-(4-chlorobenzyl)-5-(propan-2-yl)-1H-indol-2-yl]-2,2-dimethylpropanoic acid  (EXP)
3-acetyldeoxynivalenol  (EXP)
3-chloropropane-1,2-diol  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-phenylprop-2-enal  (EXP)
4'-hydroxydiclofenac  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (EXP)
4-chloro-m-cresol  (ISO)
4-hydroxy-TEMPO  (EXP)
4-hydroxynon-2-enal  (EXP)
4-methylhistamine  (ISO)
4-nitroquinoline N-oxide  (EXP)
4-nonylphenol  (ISO)
4-octylphenol  (ISO)
4-phenylbutyric acid  (EXP)
4-tolyl isocyanate  (EXP)
5-[3-(tert-butylamino)-2-hydroxypropoxy]-1,2,3,4-tetrahydronaphthalene-2,3-diol  (EXP)
5-aminoimidazole-4-carboxamide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-fluorouracil  (EXP,ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (EXP)
6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide  (ISO)
6-propyl-2-thiouracil  (ISO)
6alpha-methylprednisolone  (EXP)
7,12-dimethyltetraphene  (ISO)
7,9-dihydro-1H-purine-2,6,8(3H)-trione  (ISO)
7-ketocholesterol  (ISO)
acetaldehyde  (ISO)
acetic acid  (ISO)
acetylsalicylic acid  (ISO)
acrolein  (ISO)
actinomycin D  (EXP)
adapalene  (ISO)
adenosine  (EXP)
adenosine 5'-[gamma-thio]triphosphate  (EXP)
aflatoxin B1  (EXP,ISO)
Aflatoxin B2 alpha  (EXP)
Aflatoxin G1  (EXP)
agathisflavone  (ISO)
albendazole  (ISO)
albuterol  (ISO)
all-trans-retinoic acid  (ISO)
all-trans-retinyl palmitate  (ISO)
alloxan  (EXP)
alpha-D-galactose  (EXP)
alpha-galactosylceramide  (EXP)
alpha-naphthoflavone  (EXP,ISO)
aluminium oxide  (ISO)
amiodarone  (ISO)
amitrole  (ISO)
amlexanox  (EXP)
ammonium chloride  (ISO)
Ammothamnine  (ISO)
amphibole asbestos  (EXP)
amphotericin B  (ISO)
anthocyanin  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (EXP)
apigenin  (EXP,ISO)
aristolochic acid A  (EXP)
arsane  (EXP,ISO)
arsenic atom  (EXP,ISO)
arsenous acid  (EXP)
asbestos  (ISO)
asperentin  (EXP)
asperuloside  (EXP)
astaxanthin  (EXP,ISO)
atrazine  (EXP,ISO)
Bardoxolone methyl  (EXP,ISO)
Bavachinin  (EXP,ISO)
beclomethasone  (ISO)
benzalkonium chloride  (EXP,ISO)
benzene  (EXP,ISO)
benzene-1,2,4-triol  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzocaine  (EXP)
berberine  (EXP,ISO)
Bergenin  (ISO)
beryllium sulfate  (ISO)
beta-D-glucan  (ISO)
biliverdin  (EXP)
bis(2-chloroethyl) sulfide  (EXP,ISO)
bis(2-ethylhexyl) phthalate  (EXP)
bisoprolol  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol A diglycidyl ether  (ISO)
bisphenol F  (EXP)
bleomycin A2  (EXP)
boric acid  (ISO)
boron atom  (ISO)
bortezomib  (ISO)
BQ 123  (EXP)
bryostatin 1  (ISO)
bucladesine  (EXP,ISO)
butachlor  (EXP)
butan-1-ol  (ISO)
butane-2,3-dione  (EXP)
butylated hydroxyanisole  (ISO)
C60 fullerene  (EXP)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
cadmium selenide  (ISO)
caffeine  (ISO)
calciol  (EXP,ISO)
calcitriol  (ISO)
Calcium propionate  (ISO)
cannabidiol  (EXP,ISO)
capsaicin  (EXP,ISO)
carbachol  (EXP)
carbamate ester  (ISO)
Carbaprostacyclin  (EXP)
carbendazim  (ISO)
carbon monoxide  (EXP,ISO)
carbon nanotube  (EXP,ISO)
carnosine  (EXP)
carrageenan  (EXP,ISO)
carteolol  (ISO)
carvedilol  (ISO)
catechol  (ISO)
cefotaxime  (ISO)
cefoxitin  (EXP)
ceftazidime pentahydrate  (ISO)
cefuroxime  (ISO)
celastrol  (EXP)
celecoxib  (EXP,ISO)
cerium trichloride  (EXP)
ceruletide  (ISO)
CGS-21680  (ISO)
chenodeoxycholic acid  (EXP)
chitosan  (ISO)
chloroethene  (EXP)
chloroquine  (EXP)
chlorpyrifos  (EXP,ISO)
cholesterol  (EXP)
choline  (EXP)
chromium atom  (ISO)
chrysin  (EXP,ISO)
ciprofloxacin  (ISO)
cis-caffeic acid  (EXP)
cisplatin  (EXP,ISO)
citronellol  (ISO)
clenbuterol  (ISO)
clodronic acid  (EXP)
clonidine  (ISO)
clonidine (amino form)  (ISO)
clonidine (imino form)  (ISO)
clozapine  (ISO)
cobalt dichloride  (EXP,ISO)
cocaine  (ISO)
coenzyme Q10  (EXP,ISO)
colforsin daropate hydrochloride  (EXP)
copper atom  (EXP)
copper(0)  (EXP)
copper(II) sulfate  (ISO)
cordycepin  (ISO)
cortisol  (ISO)
costunolide  (EXP)
coumarins  (EXP)
crocidolite asbestos  (EXP,ISO)
crocin-1  (ISO)
crotonaldehyde  (ISO)
curcumin  (EXP,ISO)
cycloastragenol  (ISO)
cycloheximide  (EXP,ISO)
Cyclopamine  (ISO)
cyclophosphamide  (EXP,ISO)
cyclosporin A  (EXP,ISO)
cyhalothrin  (ISO)
cypermethrin  (EXP,ISO)
D-penicillamine  (ISO)
danazol  (ISO)
dantrolene  (ISO)
dapagliflozin  (ISO)
DAPT  (ISO)
decabromodiphenyl ether  (EXP,ISO)
deguelin  (ISO)
deoxycholic acid  (EXP)
deoxynivalenol  (EXP)
desferrioxamine B  (ISO)
dexamethasone  (EXP,ISO)
dextran  (EXP)
dextran sulfate  (EXP,ISO)
dextromethorphan  (EXP)
diallyl trisulfide  (EXP)
diarsenic trioxide  (EXP)
diazinon  (EXP)
diazoxide  (ISO)
dichloroacetic acid  (EXP)
dichloromethane  (EXP)
diclofenac  (ISO)
dicyclohexylmethane-4,4'-diisocyanate  (EXP)
Didecyldimethylammonium  (EXP)
dieldrin  (ISO)
diethyl maleate  (ISO)
diisopropyl fluorophosphate  (EXP)
Dimaprit  (ISO)
dimethoate  (ISO)
dioxygen  (EXP,ISO)
diphenylmethane-4,4'-diisocyanate  (EXP)
diprotium oxide  (ISO)
disodium selenite  (ISO)
dobutamine  (EXP,ISO)
donepezil hydrochloride  (EXP)
dopamine  (ISO)
dorsomorphin  (EXP,ISO)
doxorubicin  (EXP,ISO)
dydrogesterone  (EXP)
edaravone  (ISO)
elemental boron  (ISO)
elemental selenium  (EXP,ISO)
emamectin benzoate  (ISO)
emodin  (EXP)
estriol  (EXP)
ethambutol  (ISO)
ethanol  (EXP,ISO)
ethionamide  (ISO)
eticlopride(1+)  (ISO)
eugenol  (EXP)
excitatory amino acid agonist  (ISO)
famotidine  (ISO)
fasudil  (ISO)
flavonoids  (ISO)
flurbiprofen  (EXP)
flutamide  (ISO)
folic acid  (EXP,ISO)
fonofos  (ISO)
formaldehyde  (EXP,ISO)
formoterol fumarate  (ISO)
fragrance  (ISO)
fructose  (ISO)
fucoidan  (ISO)
fulvestrant  (ISO)
furan  (ISO)
furosemide  (ISO)
gadolinium trichloride  (ISO)
galactose  (EXP)
galanthamine  (ISO)
gemcitabine  (ISO)
gemfibrozil  (ISO)
Geniposide  (EXP)
genistein  (EXP,ISO)
gentamycin  (EXP,ISO)
geraniol  (EXP,ISO)
gliclazide  (ISO)
glucuronoxylomannan  (ISO)
glutathione  (ISO)
glycocholic acid  (EXP)
glyphosate  (EXP,ISO)
gold atom  (EXP)
gold(0)  (EXP)
gossypin  (ISO)
graphite  (EXP)
haloperidol  (EXP)
helenalin  (ISO)
heroin  (ISO)
hexachlorobenzene  (EXP,ISO)
hexadecanoic acid  (EXP)
hexamethylene diisocyanate  (EXP)
histamine  (ISO)
HU-308  (EXP,ISO)
hydralazine  (ISO)
hydrogen peroxide  (EXP,ISO)
hydroquinone  (EXP,ISO)
hydroxychloroquine  (ISO)
hydroxylamine  (ISO)
hydroxysafflor yellow A  (EXP)
hypochlorous acid  (EXP)
ibrutinib  (ISO)
ibuprofen  (ISO)
IC-87114  (EXP)
idelalisib  (EXP)
imidacloprid  (ISO)
imipramine  (EXP)
imiquimod  (ISO)
indirubin-3'-monoxime  (EXP)
indole-3-methanol  (EXP,ISO)
indometacin  (EXP,ISO)
ionomycin  (EXP,ISO)
irinotecan  (EXP,ISO)
isatin  (ISO)
isoliquiritigenin  (EXP)
isoniazide  (ISO)
isophorone diisocyanate  (EXP)
isoprenaline  (EXP,ISO)
isotretinoin  (ISO)
ivermectin  (ISO)
kaempferol  (ISO)
kaempferol 3-O-beta-D-glucoside  (EXP)
kainic acid  (ISO)
ketoprofen  (EXP)
L-ascorbic acid  (ISO)
L-methionine  (EXP)
lansoprazole  (ISO)
lead diacetate  (EXP,ISO)
lead(0)  (EXP)
lead(II) chloride  (EXP)
leflunomide  (EXP)
letrozole  (ISO)
leukotriene B4  (EXP)
linagliptin  (ISO)
linoleic acid  (ISO)
linuron  (EXP)
lipoic acid  (ISO)
lipophosphoglycan  (ISO)
lipopolysaccharide  (EXP,ISO)
lipoteichoic acid  (ISO)
lipoxin A4  (EXP)
lithium atom  (EXP)
lithium hydride  (EXP)
lithocholic acid  (EXP)
losartan  (ISO)
lupeol  (ISO)
luteolin  (EXP,ISO)
lycopene  (EXP,ISO)
mangiferin  (ISO)
mechlorethamine  (ISO)
melatonin  (EXP,ISO)
mercury atom  (EXP)
mercury dichloride  (EXP,ISO)
mercury(0)  (EXP)
mesalamine  (ISO)
metam  (EXP)
metformin  (EXP,ISO)
methadone  (ISO)
methamphetamine  (EXP,ISO)
methapyrilene  (ISO)
methimazole  (ISO)
methotrexate  (EXP,ISO)
methyl 3,4,5-trihydroxybenzoate  (EXP)
methyl isocyanate  (ISO)
methyl isothiocyanate  (EXP)
methyl methanesulfonate  (ISO)
Methyl palmitate  (EXP)
methylisothiazolinone  (ISO)
methylmercury chloride  (ISO)
metronidazole  (EXP)
metyrapone  (ISO)
microcystin-LR  (EXP,ISO)
mifepristone  (EXP,ISO)
minocycline  (EXP,ISO)
misoprostol  (ISO)
mitogen  (EXP,ISO)
MK-2206  (ISO)
mometasone furoate  (ISO)
mono(2-ethylhexyl) phthalate  (EXP)
Monobutylphthalate  (ISO)
monocrotaline  (EXP,ISO)
Monocyte locomotion inhibitory factor  (ISO)
monosodium L-glutamate  (EXP)
Morroniside  (EXP,ISO)
mycophenolic acid  (ISO)
mycotoxin  (EXP)
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine  (ISO)
N,N-diethyl-m-toluamide  (EXP,ISO)
N,N-dimethylacetamide  (EXP,ISO)
N-acetyl-L-cysteine  (EXP,ISO)
N-methyl-4-phenylpyridinium  (EXP)
N-methyl-N-nitrosourea  (EXP,ISO)
N-nitrosodiethylamine  (EXP,ISO)
N-nitrosodimethylamine  (ISO)
N1'-[2-[[5-[(dimethylamino)methyl]-2-furanyl]methylthio]ethyl]-N1-methyl-2-nitroethene-1,1-diamine  (ISO)
nadolol  (EXP)
naproxen  (ISO)
naringin  (EXP,ISO)
neostigmine  (ISO)
nickel atom  (ISO)
nickel dichloride  (EXP,ISO)
nickel sulfate  (ISO)
nicotinamide  (EXP)
nicotine  (EXP,ISO)
nimesulide  (ISO)
nitric oxide  (ISO)
nitrogen dioxide  (ISO)
Nonylphenol  (ISO)
notoginsenoside R1  (EXP)
NS-398  (EXP)
obeticholic acid  (EXP)
ochratoxin A  (ISO)
olanzapine  (EXP)
Olmesartan medoxomil  (ISO)
omeprazole  (EXP)
oridonin  (ISO)
orlistat  (ISO)
oroxylin A  (ISO)
oxidopamine  (EXP)
ozone  (EXP,ISO)
paclitaxel  (EXP,ISO)
paeoniflorin  (EXP,ISO)
palmitoyl ethanolamide  (EXP)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
parathion  (ISO)
paroxetine  (ISO)
patchouli alcohol  (ISO)
patulin  (ISO)
pentachlorophenol  (EXP)
pentamidine  (EXP)
Pentoxifylline  (EXP)
peptidoglycan  (EXP,ISO)
perfluorodecanoic acid  (EXP)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (ISO)
perindopril  (ISO)
permethrin  (ISO)
phenanthrene  (ISO)
phenanthridone  (ISO)
phenethyl isothiocyanate  (EXP)
phenobarbital  (ISO)
phloretin  (ISO)
phorbol 13-acetate 12-myristate  (EXP,ISO)
phosgene  (ISO)
phosphatidylcholine  (EXP)
phthalaldehyde  (EXP)
phthalic anhydride  (EXP)
pinostrobin  (ISO)
pioglitazone  (EXP,ISO)
pirinixic acid  (EXP,ISO)
platycodin D  (EXP)
poly(I:C)  (EXP,ISO)
polymyxin B2  (EXP)
polyphosphates  (ISO)
pomalidomide  (ISO)
potassium chloride  (ISO)
prednisolone  (EXP,ISO)
procyanidin B2  (ISO)
procyanidin B3  (EXP)
progesterone  (EXP,ISO)
propamocarb  (EXP)
propionic acid  (EXP,ISO)
propofol  (ISO)
propranolol  (ISO)
prostaglandin E2  (EXP,ISO)
prostaglandin F2alpha  (ISO)
prostaglandin I2  (ISO)
protein kinase inhibitor  (EXP,ISO)
pyocyanine  (EXP)
pyrethrins  (ISO)
Pyridostigmine bromide  (EXP,ISO)
pyrrolidine dithiocarbamate  (ISO)
quercetin  (EXP,ISO)
ranitidine  (ISO)
raspberry ketone  (ISO)
rebaudioside A  (ISO)
reserpine  (ISO)
resiniferatoxin  (ISO)
resiquimod  (EXP,ISO)
resveratrol  (EXP,ISO)
Rhein  (EXP)
ribavirin  (EXP,ISO)
rifampicin  (ISO)
rifaximin  (EXP)
rimonabant  (EXP)
Ro 41-5253  (ISO)
rolipram  (ISO)
rosmarinic acid  (ISO)
rotenone  (EXP,ISO)
rutin  (ISO)
ruxolitinib  (EXP)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (EXP,ISO)
S-nitrosoglutathione  (ISO)
SB 203580  (EXP,ISO)
SCH 23390  (ISO)
scopolamine  (EXP)
scopoletin  (ISO)
selenium atom  (EXP,ISO)
serpentine asbestos  (EXP,ISO)
sevoflurane  (EXP)
silicon dioxide  (EXP,ISO)
silver atom  (ISO)
silver(0)  (ISO)
simvastatin  (EXP,ISO)
Sinomenine  (EXP)
sirolimus  (EXP,ISO)
sodium arsenate  (ISO)
sodium arsenite  (EXP,ISO)
sodium aurothiomalate  (ISO)
sodium benzoate  (ISO)
sodium dichromate  (ISO)
Sodium salicylate  (ISO)
sodium stibogluconate  (EXP,ISO)
spironolactone  (ISO)
SR 144528  (EXP)
sterigmatocystin  (EXP,ISO)
stigmasterol  (ISO)
streptozocin  (EXP,ISO)
sucrose  (EXP)
sulfasalazine  (EXP,ISO)
sulforaphane  (EXP)
sulfoxaflor  (ISO)
sulfur dioxide  (ISO)
sumatriptan  (ISO)
sunitinib  (EXP,ISO)
suramin  (ISO)
synephrine  (EXP)
syringic acid  (ISO)
T-2 toxin  (EXP)
tacrine  (EXP)
tamibarotene  (ISO)
tangeretin  (ISO)
taurine  (EXP)
tauro-beta-muricholic acid  (EXP)
taurochenodeoxycholic acid  (EXP)
taurocholic acid  (EXP)
taurodeoxycholic acid  (EXP)
tauroursodeoxycholic acid  (EXP)
telmisartan  (ISO)
terbufos  (ISO)
terbutaline  (ISO)
Terfenadine  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP,ISO)
tetracyclines  (EXP)
thalidomide  (EXP,ISO)
theophylline  (EXP)
thiacloprid  (ISO)
thioacetamide  (EXP,ISO)
thymol  (ISO)
thymol sulfate(1-)  (ISO)
thymoquinone  (ISO)
thyroxine  (ISO)
titanium dioxide  (EXP,ISO)
TMC-120A  (EXP)
tofacitinib  (EXP)
toluene 2,4-diisocyanate  (EXP)
trans-caffeic acid  (EXP)
trans-rhaponticin  (ISO)
tributylstannane  (EXP)
trichloroacetic acid  (ISO)
trichloroethene  (ISO)
triclocarban  (EXP)
trimellitic anhydride  (EXP)
trimethyltin  (EXP)
Triptolide  (EXP)
triptonide  (EXP)
troglitazone  (EXP)
uranium atom  (EXP,ISO)
urethane  (EXP)
ursodeoxycholic acid  (EXP,ISO)
valproic acid  (EXP,ISO)
vanadium atom  (ISO)
vanadium(0)  (ISO)
vancomycin  (EXP,ISO)
vinclozolin  (ISO)
vinorelbine  (EXP)
vitamin E  (EXP,ISO)
water  (ISO)
WIN 55212-2  (EXP,ISO)
zearalenone  (EXP)
zidovudine  (ISO)
zinc acetate  (ISO)
zinc atom  (ISO)
zinc dichloride  (EXP)
zinc oxide  (EXP)
zinc protoporphyrin  (ISO)
zinc(0)  (ISO)
zoledronic acid  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
branching involved in labyrinthine layer morphogenesis  (IMP)
cellular response to antibiotic  (ISO)
cellular response to estradiol stimulus  (ISO)
cellular response to hepatocyte growth factor stimulus  (IDA)
cellular response to lipopolysaccharide  (IDA,ISO)
cellular response to virus  (ISO)
chronic inflammatory response to antigenic stimulus  (IMP)
defense response to bacterium  (IDA)
defense response to protozoan  (IDA)
immune response  (ISO)
liver regeneration  (ISO)
negative regulation of apoptotic process  (ISO)
negative regulation of autophagy  (ISO)
negative regulation of B cell proliferation  (ISO)
negative regulation of cell population proliferation  (IMP)
negative regulation of chronic inflammatory response to antigenic stimulus  (IMP)
negative regulation of cytokine production  (ISO)
negative regulation of cytokine production involved in immune response  (ISO)
negative regulation of endothelial cell apoptotic process  (IGI,ISO)
negative regulation of heterotypic cell-cell adhesion  (IGI)
negative regulation of inflammatory response  (IMP,ISO)
negative regulation of interleukin-12 production  (IMP)
negative regulation of interleukin-6 production  (ISO)
negative regulation of membrane protein ectodomain proteolysis  (ISO)
negative regulation of MHC class II biosynthetic process  (ISO)
negative regulation of myeloid dendritic cell activation  (IMP)
negative regulation of neuron apoptotic process  (ISO)
negative regulation of nitric oxide biosynthetic process  (ISO)
negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway  (IGI)
negative regulation of tumor necrosis factor production  (IMP,ISO)
negative regulation of type II interferon production  (IMP)
negative regulation of vascular associated smooth muscle cell proliferation  (IGI)
positive regulation of B cell apoptotic process  (ISO)
positive regulation of cell cycle  (IGI)
positive regulation of cytokine production  (ISO)
positive regulation of DNA-templated transcription  (ISO)
positive regulation of endothelial cell proliferation  (IGI)
positive regulation of immunoglobulin production  (ISO)
positive regulation of macrophage activation  (ISO)
positive regulation of MHC class II biosynthetic process  (IDA)
positive regulation of miRNA transcription  (ISO)
positive regulation of plasma cell differentiation  (ISO)
positive regulation of receptor signaling pathway via JAK-STAT  (ISO)
positive regulation of sprouting angiogenesis  (IMP)
positive regulation of transcription by RNA polymerase II  (IDA)
regulation of complement-dependent cytotoxicity  (ISO)
regulation of gene expression  (ISO)
regulation of response to wounding  (IMP)
regulation of synapse organization  (ISO)
response to activity  (ISO)
response to carbon monoxide  (ISO)
response to glucocorticoid  (ISO)
response to inactivity  (ISO)
response to insulin  (ISO)
response to lipopolysaccharide  (ISO)
response to molecule of bacterial origin  (ISO)
response to organic substance  (ISO)
response to xenobiotic stimulus  (ISO)

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal arterial thrombosis  (IAGP)
abnormal B cell physiology  (IAGP)
abnormal blood coagulation  (IAGP)
abnormal bone mineralization  (IAGP)
abnormal bone structure  (IAGP)
abnormal CD4-positive, alpha-beta T cell physiology  (IAGP)
abnormal CD8-positive, alpha-beta T cell physiology  (IAGP)
abnormal chemokine level  (IAGP)
abnormal circulating cholesterol level  (IAGP)
abnormal circulating cytokine level  (IAGP)
abnormal circulating enzyme level  (IAGP)
abnormal circulating interleukin-12b level  (IAGP)
abnormal circulating interleukin-6 level  (IAGP)
abnormal circulating protein level  (IAGP)
abnormal circulating serum albumin level  (IAGP)
abnormal colon morphology  (IAGP)
abnormal crypts of Lieberkuhn morphology  (IAGP)
abnormal cytokine level  (IAGP)
abnormal cytokine secretion  (IAGP)
abnormal enterocyte morphology  (IAGP)
abnormal glucose homeostasis  (IAGP)
abnormal gut flora balance  (IAGP)
abnormal homeostasis  (IAGP)
abnormal hypersensitivity reaction  (IAGP)
abnormal immune system physiology  (IAGP)
abnormal inflammatory response  (IAGP)
abnormal innate immunity  (IAGP)
abnormal interferon level  (IAGP)
abnormal interleukin level  (IAGP)
abnormal intestinal epithelium morphology  (IAGP)
abnormal intestinal mucosa morphology  (IAGP)
abnormal intestine physiology  (IAGP)
abnormal iron level  (IAGP)
abnormal Langerhans cell physiology  (IAGP)
abnormal large intestine morphology  (IAGP)
abnormal leukocyte morphology  (IAGP)
abnormal level of surface class II molecules  (IAGP)
abnormal lipid level  (IAGP)
abnormal liver physiology  (IAGP)
abnormal lymph node cell ratio  (IAGP)
abnormal lymph node morphology  (IAGP)
abnormal lymphocyte cell number  (IAGP)
abnormal myeloid leukocyte morphology  (IAGP)
abnormal myelopoiesis  (IAGP)
abnormal neuron physiology  (IAGP)
abnormal nitric oxide homeostasis  (IAGP)
abnormal osteoblast differentiation  (IAGP)
abnormal placental labyrinth vasculature morphology  (IAGP)
abnormal protein level  (IAGP)
abnormal regulatory T cell physiology  (IAGP)
abnormal reproductive system physiology  (IAGP)
abnormal response to infection  (IAGP)
abnormal skeleton morphology  (IAGP)
abnormal skeleton physiology  (IAGP)
abnormal sleep pattern  (IAGP)
abnormal splenic cell ratio  (IAGP)
abnormal T-helper 1 cell differentiation  (IAGP)
abnormal T-helper 1 physiology  (IAGP)
abnormal T-helper 2 cell differentiation  (IAGP)
abnormal T-helper 2 physiology  (IAGP)
abnormal thymus corticomedullary boundary morphology  (IAGP)
abnormal thymus involution  (IAGP)
abnormal trabecular bone morphology  (IAGP)
abnormal tumor necrosis factor level  (IAGP)
abnormal type IV hypersensitivity reaction  (IAGP)
absent erythroid progenitor cell  (IAGP)
absent spleen white pulp  (IAGP)
alveolar process atrophy  (IAGP)
anemia  (IAGP)
ataxia  (IEA)
cachexia  (IAGP)
cecum inflammation  (IAGP)
chronic inflammation  (IAGP)
colitis  (IAGP)
crypts of Lieberkuhn abscesses  (IAGP)
decreased airway responsiveness  (IAGP)
decreased body weight  (IAGP)
decreased bone mineral content  (IAGP)
decreased bone strength  (IAGP)
decreased bone trabecula number  (IAGP)
decreased circulating cholesterol level  (IAGP)
decreased circulating creatinine level  (IAGP)
decreased circulating insulin level  (IAGP)
decreased circulating interleukin-10 level  (IAGP)
decreased circulating iron level  (IAGP)
decreased circulating VLDL cholesterol level  (IAGP)
decreased colon length  (IAGP)
decreased compact bone mass  (IAGP)
decreased erythrocyte cell number  (IAGP)
decreased hemoglobin content  (IAGP)
decreased incidence of tumors by UV induction  (IAGP)
decreased interferon-gamma secretion  (IAGP)
decreased interleukin-10 secretion  (IAGP)
decreased length of allograft survival  (IAGP)
decreased lymphocyte cell number  (IAGP)
decreased mean systemic arterial blood pressure  (IAGP)
decreased physiological sensitivity to xenobiotic  (IAGP)
decreased Purkinje cell number  (IEA)
decreased spleen iron level  (IAGP)
decreased spleen red pulp amount  (IAGP)
decreased susceptibility to experimental autoimmune encephalomyelitis  (IAGP)
decreased susceptibility to induced choroidal neovascularization  (IAGP)
decreased susceptibility to induced colitis  (IAGP)
decreased T cell proliferation  (IAGP)
decreased trabecular bone mass  (IAGP)
decreased trabecular bone thickness  (IAGP)
decreased tumor incidence  (IAGP)
decreased vasoconstriction  (IAGP)
diarrhea  (IAGP)
enhanced wound healing  (IAGP)
enlarged mesenteric lymph nodes  (IAGP)
enlarged spleen  (IAGP)
extended life span  (IAGP)
hypochromic anemia  (IAGP)
impaired adaptive thermogenesis  (IAGP)
impaired coordination  (IAGP)
impaired exercise endurance  (IAGP)
increased B cell number  (IAGP)
increased CD4-positive, alpha-beta T cell number  (IAGP)
increased cerebral infarct size  (IAGP)
increased circulating cholesterol level  (IAGP)
increased circulating interferon-gamma level  (IAGP)
increased circulating interleukin-1 alpha level  (IAGP)
increased circulating interleukin-1 beta level  (IAGP)
increased circulating interleukin-12 level  (IAGP)
increased circulating interleukin-17 level  (IAGP)
increased circulating interleukin-2 level  (IAGP)
increased circulating interleukin-6 level  (IAGP)
increased circulating LDL cholesterol level  (IAGP)
increased circulating tumor necrosis factor level  (IAGP)
increased colon adenocarcinoma incidence  (IAGP)
increased fatty acids level  (IAGP)
increased granulocyte number  (IAGP)
increased hepatocyte apoptosis  (IAGP)
increased IgE level  (IAGP)
increased IgG1 level  (IAGP)
increased IgG2a level  (IAGP)
increased insulin sensitivity  (IAGP)
increased interferon-gamma secretion  (IAGP)
increased interleukin-12 secretion  (IAGP)
increased interleukin-12a secretion  (IAGP)
increased interleukin-12b secretion  (IAGP)
increased interleukin-13 secretion  (IAGP)
increased interleukin-6 secretion  (IAGP)
increased intestinal adenocarcinoma incidence  (IAGP)
increased large intestine adenocarcinoma incidence  (IAGP)
increased leukotriene level  (IAGP)
increased liver triglyceride level  (IAGP)
increased macrophage cell number  (IAGP)
increased myeloid dendritic cell number  (IAGP)
increased myocardial infarct size  (IAGP)
increased neutrophil cell number  (IAGP)
increased placental labyrinth size  (IAGP)
increased plasma cell number  (IAGP)
increased spleen red pulp amount  (IAGP)
increased susceptibility to atherosclerosis  (IAGP)
increased susceptibility to bacterial infection  (IAGP)
increased susceptibility to endotoxin shock  (IAGP)
increased susceptibility to induced colitis  (IAGP)
increased susceptibility to induced morbidity/mortality  (IAGP)
increased susceptibility to neuronal excitotoxicity  (IAGP)
increased susceptibility to parasitic infection  (IAGP)
increased susceptibility to type IV hypersensitivity reaction  (IAGP)
increased T cell apoptosis  (IAGP)
increased T cell number  (IAGP)
increased thermal nociceptive threshold  (IAGP)
increased thymus weight  (IAGP)
increased tumor necrosis factor secretion  (IAGP)
increased vasoconstriction  (IAGP)
intestinal inflammation  (IAGP)
intestinal ulcer  (IAGP)
large intestinal inflammation  (IAGP)
liver inflammation  (IAGP)
lung inflammation  (IAGP)
microcytic anemia  (IAGP)
no abnormal phenotype detected  (IAGP)
peritoneal inflammation  (IAGP)
postnatal growth retardation  (IAGP)
premature death  (IAGP)
rectal prolapse  (IAGP)
short femur  (IAGP)
slow postnatal weight gain  (IAGP)
small intestinal inflammation  (IAGP)
spleen hyperplasia  (IAGP)
thymus hyperplasia  (IAGP)
thymus hypoplasia  (IAGP)
tremors  (IEA)
weight loss  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. Cytokine and CXC chemokine expression patterns in aqueous humor of patients with presumed tuberculous uveitis. Abu El-Asrar AM, etal., Cytokine. 2012 Aug;59(2):377-81. doi: 10.1016/j.cyto.2012.04.030. Epub 2012 May 12.
2. Molecular analysis of interleukin-10 gene polymorphisms in patients with Behçet's disease. Afkari B, etal., Immunol Lett. 2018 Feb;194:56-61. doi: 10.1016/j.imlet.2017.12.008. Epub 2017 Dec 30.
3. Abrogation of anti-retinal autoimmunity in IL-10 transgenic mice due to reduced T cell priming and inhibition of disease effector mechanisms. Agarwal RK, etal., J Immunol. 2008 Apr 15;180(8):5423-9.
4. Down-regulation of IFN-gamma-producing CD56+ T cells after combined low-dose cyclosporine/prednisone treatment in patients with Behcet's uveitis. Ahn JK, etal., Invest Ophthalmol Vis Sci. 2005 Jul;46(7):2458-64.
5. Hypermethylation of IL-10 gene is responsible for its low mRNA expression in Behçet's disease. Alipour S, etal., J Cell Biochem. 2018 Aug;119(8):6614-6622. doi: 10.1002/jcb.26809. Epub 2018 May 2.
6. Cytokine polymorphisms predict the frequency of otitis media as a complication of rhinovirus and RSV infections in children. Alper CM, etal., Eur Arch Otorhinolaryngol. 2009 Feb;266(2):199-205. doi: 10.1007/s00405-008-0729-2. Epub 2008 Jun 17.
7. Anti-inflammatory cytokines in subclinical carotid atherosclerosis. Ambrosius W, etal., Neurology. 2006 Jun 27;66(12):1946-8.
8. Genetic variants in inflammation pathway genes and asthma in glioma susceptibility. Amirian E, etal., Neuro Oncol. 2010 May;12(5):444-52. Epub 2010 Feb 5.
9. Regulatory B cells prevent and reverse allergic airway inflammation via FoxP3-positive T regulatory cells in a murine model. Amu S, etal., J Allergy Clin Immunol. 2010 May;125(5):1114-1124.e8. Epub 2010 Mar 20.
10. Interleukin 10 (IL-10) influences autoimmune response in primary Sjogren's syndrome and is linked to IL-10 gene polymorphism. Anaya JM, etal., J Rheumatol. 2002 Sep;29(9):1874-6.
11. Physical Exercise Improves Glycemic and Inflammatory Profile and Attenuates Progression of Periodontitis in Diabetic Rats (HFD/STZ). Andrade EF, etal., Nutrients. 2018 Nov 7;10(11). pii: nu10111702. doi: 10.3390/nu10111702.
12. Macrophages inhibit neovascularization in a murine model of age-related macular degeneration. Apte RS, etal., PLoS Med. 2006 Aug;3(8):e310.
13. Dysregulated phosphorylation and nuclear translocation of cyclic AMP response element binding protein (CREB) in rat liver after chronic ethanol binge. Aroor AR, etal., Eur J Pharmacol. 2012 Mar 15;679(1-3):101-8. doi: 10.1016/j.ejphar.2011.12.045. Epub 2012 Jan 15.
14. TNF-α and IL-10 polymorphisms increase the risk to hepatocellular carcinoma in HCV infected individuals. Aroucha DC, etal., J Med Virol. 2016 Sep;88(9):1587-95. doi: 10.1002/jmv.24501. Epub 2016 Mar 21.
15. Cytokine polymorphism in noninfectious uveitis. Atan D, etal., Invest Ophthalmol Vis Sci. 2010 Aug;51(8):4133-42. doi: 10.1167/iovs.09-4583. Epub 2010 Mar 24.
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PMID:24723679   PMID:24742125   PMID:24743235   PMID:24743305   PMID:24745333   PMID:24747960   PMID:24760014   PMID:24768298   PMID:24782616   PMID:24787713   PMID:24792913   PMID:24803538  
PMID:24809349   PMID:24835395   PMID:24849654   PMID:24882466   PMID:24890725   PMID:24906621   PMID:24907347   PMID:24938765   PMID:24938868   PMID:24947351   PMID:24966183   PMID:24967703  
PMID:24970737   PMID:24970861   PMID:24990750   PMID:25003188   PMID:25012660   PMID:25014110   PMID:25015957   PMID:25030062   PMID:25072499   PMID:25073792   PMID:25074917   PMID:25080448  
PMID:25083083   PMID:25092334   PMID:25098409   PMID:25105363   PMID:25108223   PMID:25114223   PMID:25127031   PMID:25144738   PMID:25147341   PMID:25163764   PMID:25168352   PMID:25172014  
PMID:25173346   PMID:25175678   PMID:25179342   PMID:25182170   PMID:25182274   PMID:25187563   PMID:25187652   PMID:25210122   PMID:25210773   PMID:25211233   PMID:25218510   PMID:25224305  
PMID:25225664   PMID:25227984   PMID:25238105   PMID:25246497   PMID:25249575   PMID:25290058   PMID:25326801   PMID:25348624   PMID:25362048   PMID:25376659   PMID:25381386   PMID:25387791  
PMID:25409540   PMID:25412627   PMID:25415335   PMID:25420919   PMID:25446845   PMID:25449577   PMID:25478691   PMID:25480159   PMID:25482126   PMID:25484301   PMID:25493020   PMID:25512602  
PMID:25527785   PMID:25544730   PMID:25545618   PMID:25550088   PMID:25582854   PMID:25586556   PMID:25595646   PMID:25599561   PMID:25605773   PMID:25607885   PMID:25609381   PMID:25614966  
PMID:25619653   PMID:25619654   PMID:25624353   PMID:25627813   PMID:25642769   PMID:25654642   PMID:25659581   PMID:25691003   PMID:25695838   PMID:25697138   PMID:25711612   PMID:25721303  
PMID:25728041   PMID:25730849   PMID:25731162   PMID:25748019   PMID:25780042   PMID:25783157   PMID:25823227   PMID:25824145   PMID:25839706   PMID:25855122   PMID:25865048   PMID:25894930  
PMID:25907690   PMID:25908537   PMID:25916989   PMID:25924064   PMID:25924065   PMID:25929785   PMID:25930741   PMID:25951109   PMID:25959063   PMID:25974019   PMID:25993317   PMID:25993756  
PMID:26032199   PMID:26035380   PMID:26056255   PMID:26056274   PMID:26059829   PMID:26063196   PMID:26067254   PMID:26072395   PMID:26088575   PMID:26110994   PMID:26116503   PMID:26121177  
PMID:26132901   PMID:26138465   PMID:26138667   PMID:26139429   PMID:26147684   PMID:26160212   PMID:26160380   PMID:26166769   PMID:26168735   PMID:26195794   PMID:26216423   PMID:26216934  
PMID:26224007   PMID:26229400   PMID:26231118   PMID:26232453   PMID:26232788   PMID:26234742   PMID:26235422   PMID:26235810   PMID:26252010   PMID:26254185   PMID:26260587   PMID:26271981  
PMID:26272906   PMID:26274807   PMID:26277566   PMID:26291441   PMID:26302924   PMID:26317471   PMID:26332085   PMID:26332507   PMID:26358260   PMID:26371131   PMID:26392556   PMID:26404745  
PMID:26408197   PMID:26416211   PMID:26438362   PMID:26456500   PMID:26506472   PMID:26549357   PMID:26602020   PMID:26603204   PMID:26608451   PMID:26616882   PMID:26646149   PMID:26653800  
PMID:26658192   PMID:26673134   PMID:26673140   PMID:26674868   PMID:26677224   PMID:26682936   PMID:26708990   PMID:26712119   PMID:26732675   PMID:26735612   PMID:26752353   PMID:26755203  
PMID:26767500   PMID:26772435   PMID:26772532   PMID:26785945   PMID:26808574   PMID:26852110   PMID:26869716   PMID:26873172   PMID:26878233   PMID:26886799   PMID:26891260   PMID:26895637  
PMID:26928119   PMID:26942885   PMID:26956044   PMID:26964093   PMID:26976823   PMID:26978520   PMID:26991092   PMID:27001179   PMID:27019327   PMID:27022145   PMID:27027442   PMID:27036736  
PMID:27045690   PMID:27065323   PMID:27075020   PMID:27078067   PMID:27079612   PMID:27085036   PMID:27125280   PMID:27129283   PMID:27147411   PMID:27151377   PMID:27159132   PMID:27160066  
PMID:27166557   PMID:27172902   PMID:27183617   PMID:27185659   PMID:27193261   PMID:27220813   PMID:27222343   PMID:27225830   PMID:27240831   PMID:27271565   PMID:27287239   PMID:27295349  
PMID:27314021   PMID:27317920   PMID:27337694   PMID:27350616   PMID:27383204   PMID:27395764   PMID:27396388   PMID:27402701   PMID:27413257   PMID:27431309   PMID:27476761   PMID:27491076  
PMID:27522641   PMID:27533281   PMID:27548066   PMID:27549173   PMID:27555458   PMID:27578867   PMID:27581189   PMID:27595832   PMID:27619993   PMID:27626662   PMID:27630165   PMID:27644327  
PMID:27655833   PMID:27665290   PMID:27671676   PMID:27696149   PMID:27701741   PMID:27706765   PMID:27714845   PMID:27734904   PMID:27811060   PMID:27837109   PMID:27863332   PMID:27872905  
PMID:27881703   PMID:27903619   PMID:27918564   PMID:27924814   PMID:27926930   PMID:27940088   PMID:27940658   PMID:28002460   PMID:28003377   PMID:28011648   PMID:28012163   PMID:28034913  
PMID:28039475   PMID:28039485   PMID:28052346   PMID:28074841   PMID:28086957   PMID:28096401   PMID:28100679   PMID:28130856   PMID:28140445   PMID:28167629   PMID:28202460   PMID:28213503  
PMID:28214022   PMID:28237664   PMID:28239679   PMID:28250159   PMID:28257233   PMID:28265004   PMID:28321419   PMID:28329706   PMID:28363868   PMID:28374774   PMID:28410507   PMID:28411859  
PMID:28416491   PMID:28432060   PMID:28439004   PMID:28439731   PMID:28445725   PMID:28469089   PMID:28471299   PMID:28473584   PMID:28474506   PMID:28483675   PMID:28526846   PMID:28553262  
PMID:28581446   PMID:28584007   PMID:28597201   PMID:28604806   PMID:28607102   PMID:28607110   PMID:28607488   PMID:28617991   PMID:28630091   PMID:28635957   PMID:28646220   PMID:28667100  
PMID:28683149   PMID:28685820   PMID:28716804   PMID:28738016   PMID:28740109   PMID:28742882   PMID:28744806   PMID:28752081   PMID:28753651   PMID:28765368   PMID:28765520   PMID:28783045  
PMID:28789949   PMID:28805801   PMID:28835457   PMID:28844693   PMID:28847894   PMID:28848066   PMID:28877953   PMID:28886863   PMID:28894001   PMID:28946616   PMID:28959012   PMID:28978474  
PMID:29016674   PMID:29023599   PMID:29040534   PMID:29051186   PMID:29053971   PMID:29054998   PMID:29072959   PMID:29144460   PMID:29145406   PMID:29196657   PMID:29229781   PMID:29249357  
PMID:29263262   PMID:29267271   PMID:29281834   PMID:29301939   PMID:29330321   PMID:29330323   PMID:29339450   PMID:29349774   PMID:29352287   PMID:29356901   PMID:29358274   PMID:29367208  
PMID:29374077   PMID:29374078   PMID:29378905   PMID:29391475   PMID:29396160   PMID:29401621   PMID:29414937   PMID:29425215   PMID:29436412   PMID:29445144   PMID:29449556   PMID:29461978  
PMID:29491381   PMID:29513410   PMID:29549351   PMID:29552291   PMID:29588316   PMID:29625893   PMID:29657255   PMID:29662170   PMID:29704005   PMID:29712773   PMID:29712774   PMID:29773644  
PMID:29844590   PMID:29847790   PMID:29848663   PMID:29851490   PMID:29866800   PMID:29898958   PMID:29946039   PMID:29967195   PMID:29980437   PMID:29983349   PMID:29985482   PMID:30005826  
PMID:30009261   PMID:30017086   PMID:30017388   PMID:30025864   PMID:30037926   PMID:30053407   PMID:30054585   PMID:30093657   PMID:30097531   PMID:30117603   PMID:30118915   PMID:30127086  
PMID:30143634   PMID:30158399   PMID:30170688   PMID:30185773   PMID:30194773   PMID:30195028   PMID:30216653   PMID:30228258   PMID:30250187   PMID:30266771   PMID:30274824   PMID:30279688  
PMID:30282028   PMID:30284926   PMID:30291029   PMID:30315190   PMID:30336455   PMID:30355617   PMID:30371945   PMID:30406179   PMID:30487586   PMID:30512224   PMID:30518790   PMID:30540937  
PMID:30542112   PMID:30548340   PMID:30566244   PMID:30575716   PMID:30581430   PMID:30600200   PMID:30610104   PMID:30612739   PMID:30619363   PMID:30635390   PMID:30639137   PMID:30642977  
PMID:30643147   PMID:30675064   PMID:30683858   PMID:30684382   PMID:30694569   PMID:30718297   PMID:30718924   PMID:30759395   PMID:30765734   PMID:30770822   PMID:30771903   PMID:30778241  
PMID:30819965   PMID:30838865   PMID:30843463   PMID:30850474   PMID:30867482   PMID:30926808   PMID:30936494   PMID:30938680   PMID:30977112   PMID:30995474   PMID:30998505   PMID:31022694  
PMID:31054259   PMID:31061528   PMID:31070504   PMID:31091151   PMID:31120919   PMID:31158699   PMID:31194881   PMID:31211512   PMID:31216373   PMID:31216428   PMID:31226434   PMID:31231033  
PMID:31235718   PMID:31244833   PMID:31246581   PMID:31249364   PMID:31264967   PMID:31301888   PMID:31311828   PMID:31328158   PMID:31339393   PMID:31358565   PMID:31358568   PMID:31361973  
PMID:31391483   PMID:31418859   PMID:31434732   PMID:31471526   PMID:31474988   PMID:31481690   PMID:31509557   PMID:31536782   PMID:31538345   PMID:31546615   PMID:31551984   PMID:31552020  
PMID:31552035   PMID:31587452   PMID:31588671   PMID:31591231   PMID:31594855   PMID:31608070   PMID:31628426   PMID:31644425   PMID:31649508   PMID:31676439   PMID:31679751   PMID:31694174  
PMID:31699824   PMID:31707128   PMID:31712941   PMID:31722204   PMID:31723081   PMID:31732166   PMID:31755523   PMID:31776239   PMID:31815595   PMID:31827095   PMID:31883840   PMID:31900338  
PMID:31900478   PMID:31932715   PMID:31940277   PMID:31959883   PMID:32012211   PMID:32012249   PMID:32016805   PMID:32036038   PMID:32049021   PMID:32075741   PMID:32103173   PMID:32127556  
PMID:32130409   PMID:32152316   PMID:32152630   PMID:32153580   PMID:32169848   PMID:32170906   PMID:32184325   PMID:32198725   PMID:32213346   PMID:32213963   PMID:32255767   PMID:32286276  
PMID:32298657   PMID:32324763   PMID:32385136   PMID:32424367   PMID:32451418   PMID:32464093   PMID:32484988   PMID:32506440   PMID:32516575   PMID:32563958   PMID:32582141   PMID:32585682  
PMID:32611425   PMID:32620760   PMID:32633848   PMID:32634590   PMID:32655552   PMID:32668241   PMID:32686763   PMID:32690657   PMID:32691494   PMID:32727246   PMID:32751234   PMID:32758418  
PMID:32814718   PMID:32817369   PMID:32817517   PMID:32828299   PMID:32898157   PMID:32905799   PMID:32917787   PMID:32941525   PMID:32961355   PMID:33028080   PMID:33049000   PMID:33049219  
PMID:33053375   PMID:33063335   PMID:33072115   PMID:33077598   PMID:33086075   PMID:33104169   PMID:33115951   PMID:33147449   PMID:33154038   PMID:33158954   PMID:33202847   PMID:33232788  
PMID:33246101   PMID:33249168   PMID:33257786   PMID:33326020   PMID:33328477   PMID:33334395   PMID:33347446   PMID:33351782   PMID:33360827   PMID:33391287   PMID:33414479   PMID:33471802  
PMID:33514512   PMID:33526653   PMID:33540122   PMID:33558374   PMID:33567272   PMID:33567810   PMID:33572870   PMID:33588074   PMID:33592337   PMID:33615201   PMID:33617447   PMID:33664727  
PMID:33664728   PMID:33674584   PMID:33677516   PMID:33710922   PMID:33750849   PMID:33753483   PMID:33763067   PMID:33789099   PMID:33828301   PMID:33951473   PMID:33953267   PMID:33979348  
PMID:33995357   PMID:34012116   PMID:34069395   PMID:34077724   PMID:34093535   PMID:34111469   PMID:34126769   PMID:34220850   PMID:34233192   PMID:34234775   PMID:34246809   PMID:34253059  
PMID:34275478   PMID:34299013   PMID:34305950   PMID:34324719   PMID:34359856   PMID:34366205   PMID:34394099   PMID:34433904   PMID:34502552   PMID:34528666   PMID:34533228   PMID:34571824  
PMID:34680083   PMID:34706233   PMID:34727170   PMID:34732892   PMID:34749531   PMID:34772416   PMID:34822777   PMID:34830316   PMID:34836549   PMID:34862717   PMID:34868049   PMID:34879221  
PMID:34919443   PMID:34919670   PMID:34924112   PMID:35073310   PMID:35089323   PMID:35095903   PMID:35107021   PMID:35145521   PMID:35181640   PMID:35260535   PMID:35303081   PMID:35354043  
PMID:35385697   PMID:35401533   PMID:35442154   PMID:35456922   PMID:35613599   PMID:35644427   PMID:35670763   PMID:35792218   PMID:35819408   PMID:35830810   PMID:35853280   PMID:35899990  
PMID:35900107   PMID:35988637   PMID:36016413   PMID:36054664   PMID:36078100   PMID:36140754   PMID:36142626   PMID:36159872   PMID:36192482   PMID:36231129   PMID:36275703   PMID:36310865  
PMID:36434690   PMID:36496494   PMID:36584137   PMID:36630911   PMID:36630913   PMID:36817487   PMID:36854993   PMID:36867536   PMID:36883358   PMID:36916087   PMID:36929236   PMID:36946983  
PMID:36973489   PMID:37000521   PMID:37036426   PMID:37047294   PMID:37201335   PMID:37202419   PMID:37296215   PMID:37326695   PMID:37373041   PMID:37512128   PMID:37653127   PMID:37717073  
PMID:37736049   PMID:37935074   PMID:37936983   PMID:37948457   PMID:37995573   PMID:38070317   PMID:38081103   PMID:38081433   PMID:38093354   PMID:38155972   PMID:38159471   PMID:38182585  
PMID:38203690   PMID:38217044   PMID:38218976   PMID:38305633  


Genomics

Comparative Map Data
Il10
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391130,947,459 - 130,952,707 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1130,947,582 - 130,952,711 (+)EnsemblGRCm39 Ensembl
GRCm381131,019,845 - 131,024,970 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1131,019,845 - 131,024,974 (+)EnsemblGRCm38mm10GRCm38
MGSCv371132,916,422 - 132,921,547 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361132,847,393 - 132,852,516 (+)NCBIMGSCv36mm8
Celera1133,642,456 - 133,647,581 (+)NCBICelera
Cytogenetic Map1E4NCBI
cM Map156.89NCBI
IL10
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381206,767,602 - 206,772,494 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1206,767,602 - 206,774,541 (-)EnsemblGRCh38hg38GRCh38
GRCh371206,940,947 - 206,945,839 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361205,007,571 - 205,012,462 (-)NCBINCBI36Build 36hg18NCBI36
Build 341203,329,342 - 203,334,234NCBI
Celera1180,192,396 - 180,197,294 (-)NCBICelera
Cytogenetic Map1q32.1NCBI
HuRef1177,639,274 - 177,644,165 (-)NCBIHuRef
CHM1_11208,213,574 - 208,218,465 (-)NCBICHM1_1
T2T-CHM13v2.01206,031,803 - 206,036,695 (-)NCBIT2T-CHM13v2.0
Il10
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81345,024,921 - 45,029,586 (+)NCBIGRCr8
mRatBN7.21342,472,625 - 42,477,308 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1342,472,839 - 42,477,313 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1345,079,495 - 45,083,368 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01346,367,625 - 46,371,502 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01343,631,889 - 43,635,783 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01347,738,933 - 47,743,392 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1347,739,526 - 47,743,392 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01352,824,594 - 52,828,560 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41343,953,900 - 43,957,766 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11343,967,906 - 43,972,374 (+)NCBI
Celera1342,821,569 - 42,825,416 (+)NCBICelera
Cytogenetic Map13q13NCBI
Il10
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540642,307,664 - 42,312,779 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540642,307,789 - 42,312,255 (-)NCBIChiLan1.0ChiLan1.0
IL10
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2142,602,021 - 42,609,622 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1142,567,540 - 42,575,040 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01182,369,234 - 182,374,207 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11186,648,289 - 186,653,155 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1186,648,289 - 186,653,371 (-)Ensemblpanpan1.1panPan2
IL10
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.175,933,285 - 5,937,057 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl75,933,285 - 5,937,057 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha75,497,391 - 5,501,163 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.075,622,589 - 5,626,365 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl75,622,079 - 5,626,428 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.175,557,139 - 5,560,910 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.075,658,009 - 5,661,775 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.075,697,728 - 5,701,500 (-)NCBIUU_Cfam_GSD_1.0
Il10
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934468,594,566 - 68,598,867 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365575,834,874 - 5,838,502 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365575,834,874 - 5,838,502 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
IL10
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl967,400,728 - 67,405,378 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1967,400,727 - 67,405,941 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2973,757,707 - 73,762,925 (-)NCBISscrofa10.2Sscrofa10.2susScr3
IL10
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12522,590,389 - 22,595,877 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2522,590,962 - 22,594,836 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605523,288,754 - 23,293,715 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Il10
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248074,687,176 - 4,691,732 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248074,687,249 - 4,691,658 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Il10
205 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:229
Count of miRNA genes:187
Interacting mature miRNAs:204
Transcripts:ENSMUST00000016673
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
13824984Twq5_mtestis weight QTL 5 (mouse)13069992184732197Mouse
11039528Ccc3_mcolitis susceptibility in the Collaborative Cross 3 (mouse)13680142195051546Mouse
1357753Kidq2_mkidney weight QTL 2 (mouse)Not determined134760138150193871Mouse
1357488Splq3_mspleen weight QTL 3 (mouse)Not determined134760138150193871Mouse
1558860W10q7_mweight 10 weeks QTL 7 (mouse)Not determined134760138150193871Mouse
1301722Cia9_mcollagen induced arthritis QTL 9 (mouse)Not determined145783900189303617Mouse
4142291Aec2_mautoimmune exocrinopathy 2 (mouse)Not determined52457737182250592Mouse
10412185Hcs9_mhepatocarcinogenesis susceptibility 9 (mouse)Not determined163854690189303617Mouse
1300841Ssial1_msusceptibility to sialadenitis 1 (mouse)Not determined163920002153557562Mouse
1300989Lrdg1_mlight induced retinal degeneration 1 (mouse)Not determined173755175147125370Mouse
4141914Gcsfis_mG-CSF induced splenomegaly (mouse)Not determined74516235148715579Mouse
1357847Jckm2_mjuvenile cystic kidney modifier 2 (mouse)Not determined174991977133290937Mouse
27095928Pglq6_mpelvic girdle length QTL 6, 10 week (mouse)175976637148775742Mouse
26884448Sklq1_mskull length QTL 1, 5 week (mouse)175976637181327565Mouse
1301350Nidd4k_mNidd4 on KK-A (mouse)Not determined782291982147125370Mouse
1357439Popoa_mpremature ovulation and primary oocyte arrest (mouse)Not determined182643189135615379Mouse
27095913Scvln2_msacral vertebrae length 2, 5 week (mouse)194127725148775742Mouse
27095901Scvln8_msacral vertebrae length 2, 10 week (mouse)194127725172027567Mouse
27226779Tibl1_mtibia length 1, 5 week (mouse)195527725162027569Mouse
1301753Tir3a_mtrypansomiasis infection response 3a (mouse)Not determined197053986131054190Mouse
1301536Pbbcp1_mperipheral blood B cell percentage 1 (mouse)Not determined199507660133507845Mouse
1301193Lxw3_mlupus BXSB x NZW 3 (mouse)Not determined1102968534136968667Mouse
10412162Nobq3_mNew Zealand obese QTL 3 (mouse)Not determined1103933405191225397Mouse
12790994Aaaq1_maortic arch angle QTL 1 (mouse)1109495943143495943Mouse
1301979Melm1_mmelanoma modifier 1 (mouse)Not determined1109638262143638479Mouse
1357600Obq17_mobesity QTL 17 (mouse)Not determined1110553179144553298Mouse
10401248Bglu12_mblood glucose level 12 (mouse)Not determined1110553179144553298Mouse
1301149Lrnx12_mlearning-contextual 12 (mouse)Not determined1112008822168186402Mouse
1302098Eila1_methanol induced locomotor activity 1 (mouse)Not determined1112008822175468938Mouse
1301249Sbw1_msplenomegaly-NZB x NZW 1 (mouse)Not determined1112131005146131085Mouse
10045640Jckm4_mjuvenile cystic kidney modifier 4 (mouse)Not determined1116290836150290937Mouse
27095915Scvln13_msacral vertebrae length 2, 16 week (mouse)1117527730179827565Mouse
1302161Exq2_mexploratory and excitability QTL 2 (mouse)Not determined1118099720152099816Mouse
27226714Metcl1_mmetatarsal-calcaneal length 1, 5 week (mouse)1121727729139727738Mouse
27226740Metcl13_mmetatarsal-calcaneal length 13, 16 week (mouse)1121727729153775746Mouse
27226743Metcl7_mmetatarsal-calcaneal length 7, 10 week (mouse)1121727729153875746Mouse
27226767Tibl10_mtibia length 10, 10 week (mouse)1121727729164827569Mouse
27226799Feml5_mfemur length 5, 5 week (mouse)1122027729164827569Mouse
12880408V125Dq3_mvitamin D active form serum level QTL 3 (mouse)1122927738156927738Mouse
27095935Ulnl5_mulna length 5, 10 week (mouse)1128727737181327565Mouse
1301608Emo3_memotionality 3 (mouse)Not determined1129130858163130993Mouse

Markers in Region
M37897  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381131,024,645 - 131,024,741UniSTSGRCm38
MGSCv371132,921,222 - 132,921,318UniSTSGRCm37
Celera1133,647,256 - 133,647,352UniSTS
Cytogenetic Map1E4UniSTS
cM Map169.9UniSTS
Whitehead/MRC_RH11730.12UniSTS
PMC321611P1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381131,021,339 - 131,021,469UniSTSGRCm38
MGSCv371132,917,916 - 132,918,046UniSTSGRCm37
Celera1133,643,950 - 133,644,080UniSTS
Cytogenetic Map1E4UniSTS
cM Map169.9UniSTS
PMC96371P1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381131,019,807 - 131,020,007UniSTSGRCm38
MGSCv371132,916,384 - 132,916,584UniSTSGRCm37
Celera1133,642,418 - 133,642,618UniSTS
Cytogenetic Map1E4UniSTS
cM Map169.9UniSTS
Il10  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381131,019,926 - 131,021,435UniSTSGRCm38
Celera1133,642,537 - 133,644,046UniSTS
Cytogenetic Map1E4UniSTS
cM Map169.9UniSTS
cM Map169.9UniSTS
Il10  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map1E4UniSTS
Il10  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map1E4UniSTS
cM Map169.9UniSTS


Expression


Sequence


RefSeq Acc Id: ENSMUST00000016673   ⟹   ENSMUSP00000016673
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1130,947,582 - 130,952,711 (+)Ensembl
GRCm38.p6 Ensembl1131,019,845 - 131,024,974 (+)Ensembl
RefSeq Acc Id: NM_010548   ⟹   NP_034678
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391130,947,582 - 130,952,707 (+)NCBI
GRCm381131,019,845 - 131,024,970 (+)ENTREZGENE
MGSCv371132,916,422 - 132,921,547 (+)RGD
Celera1133,642,456 - 133,647,581 (+)RGD
cM Map1 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_036162094   ⟹   XP_036017987
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391130,947,459 - 130,950,957 (+)NCBI
Sequence:
RefSeq Acc Id: NP_034678   ⟸   NM_010548
- Peptide Label: precursor
- UniProtKB: Q0VBJ1 (UniProtKB/Swiss-Prot),   P18893 (UniProtKB/Swiss-Prot),   Q3U879 (UniProtKB/TrEMBL),   A0A7R8GUQ3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000016673   ⟸   ENSMUST00000016673
RefSeq Acc Id: XP_036017987   ⟸   XM_036162094
- Peptide Label: isoform X1
- UniProtKB: Q3U879 (UniProtKB/TrEMBL)

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P18893-F1-model_v2 AlphaFold P18893 1-178 view protein structure

Promoters
RGD ID:6874846
Promoter ID:EPDNEW_M874
Type:multiple initiation site
Name:Il10_1
Description:Mus musculus interleukin 10 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381131,019,847 - 131,019,907EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:96537 AgrOrtholog
Ensembl Genes ENSMUSG00000016529 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000016673 ENTREZGENE
  ENSMUST00000016673.6 UniProtKB/Swiss-Prot
Gene3D-CATH 1.20.1250.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro 4_helix_cytokine-like_core UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IL-10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IL-10/19/20/22/24/26_fam UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IL-10_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:16153 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:96537 ENTREZGENE
NCBI Gene 16153 ENTREZGENE
Pfam IL10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB IL10 RGD
PhenoGen Il10 PhenoGen
PRINTS INTRLEUKIN10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE INTERLEUKIN_10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART IL10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF47266 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A7R8GUQ3 ENTREZGENE, UniProtKB/TrEMBL
  IL10_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q0VBJ1 ENTREZGENE
  Q3U879 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary Q0VBJ1 UniProtKB/Swiss-Prot