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TRANSFORMING GROWTH FACTOR-BETA SMAD DEPENDENT SIGNALING PATHWAY (PW:0000490)

View Ontology Report

Description

Transforming growth factor-beta superfamily mediated pathways are central regulators of proliferation and survival, migration and differentiation, angiogenesis, embryonic development and wound healing. The superfamily of ligands can be divided into two main groups: the Tgf-b/activin and the bone morphogenetic protein (BMP)/growth and differentiation factor (GDF) - both can be further subdivided. The serine/threonine kinase receptor superfamily is represented by the type I and II receptors that c

Pathway Diagram:

Elsevier Inc. Dcn A2m Tgfbr3 Smad7 Fkbp1a Smad4 Smad3 ---- Zfyve9 Smad2 Smad3 Translocated Smad Zfyve9 Tgfb1 Tgfbr1 Tgfbr2 Smad7 ---| Tgfbr1 Smurf2 Smurf1 Tgf-beta target genes Transcription factors/co-activators Smad2 ---- Smad4 Fkbp1a ---| Tgfbr1 A2m ---| Tgfb1 Tgfbr2 --+> Tgfbr1 Smad7 ---| Tgfbr1 Smad3 ---- Smad4 Smad2 ---- Zfyve9 Tgfbr1 ---- Zfyve9 Tgfbr1 --+> Smad2 Tgfbr1 --+> Smad3 Tgfb1 ---- Tgfbr1 Tgfb1 ---- Tgfbr3 Dcn ---| Tgfb1 Tgfb1 ---- Tgfbr2 Smad3 ---> Translocated Smad Smad2 ---> Translocated Smad Smad4 ---> Translocated Smad Translocated Smad ---> Tgf-beta target genes Tgf-beta target genes ---> Smad7
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Genes in Pathway:


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transforming growth factor-beta Smad dependent signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G A2m alpha-2-macroglobulin IMP RGD PMID:12809600 RGD:2298922 NCBI chr 4:154,897,770...154,947,787
Ensembl chr 4:154,897,877...154,947,786
JBrowse link
G Arrb2 arrestin, beta 2 ISO PID PID:200227 NCBI chr10:55,146,887...55,154,854
Ensembl chr10:55,146,818...55,154,850
JBrowse link
G Atf3 activating transcription factor 3 ISO RGD PMID:18061509 PMID:16322555 RGD:5143919, RGD:2302137 NCBI chr13:102,751,278...102,800,520
Ensembl chr13:102,751,321...102,764,631
JBrowse link
G Axin1 axin 1 ISO PID PID:200227 NCBI chr10:15,163,477...15,215,615
Ensembl chr10:15,163,684...15,215,615
JBrowse link
G Bambi BMP and activin membrane-bound inhibitor ISO PID PID:200227 NCBI chr17:54,121,251...54,125,816
Ensembl chr17:54,121,255...54,126,060
JBrowse link
G Camk2a calcium/calmodulin-dependent protein kinase II alpha ISO PID PID:200227 NCBI chr18:54,378,642...54,441,120
Ensembl chr18:54,378,784...54,438,994
JBrowse link
G Cav1 caveolin 1 ISO PID PID:200227 NCBI chr 4:45,640,624...45,673,708
Ensembl chr 4:45,634,918...45,673,705
JBrowse link
G Ccn2 cellular communication network factor 2 ISO PID PID:200227 NCBI chr 1:20,802,199...20,805,315
Ensembl chr 1:20,802,199...20,805,734
JBrowse link
G Creb1 cAMP responsive element binding protein 1 IMP RGD PMID:16891311 RGD:1625706 NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816
JBrowse link
G Crebbp CREB binding protein ISO RGD PMID:18061509 PMID:16322555 RGD:5143919, RGD:2302137 NCBI chr10:11,335,551...11,461,888
Ensembl chr10:11,335,953...11,461,888
JBrowse link
G Ctnnb1 catenin beta 1 ISO PID PID:200227 NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111
JBrowse link
G Dact2 dishevelled-binding antagonist of beta-catenin 2 ISO PID PID:200227 NCBI chr 1:55,181,023...55,191,026
Ensembl chr 1:55,181,024...55,191,096
JBrowse link
G Daxx death-domain associated protein ISO PID PID:200227 NCBI chr20:4,970,090...4,976,145
Ensembl chr20:4,970,092...4,975,843
JBrowse link
G Dcn decorin ISO RGD PMID:12809600 RGD:2298922 NCBI chr 7:32,281,252...32,321,291
Ensembl chr 7:32,281,252...32,321,270
JBrowse link
G Dynlrb1 dynein light chain roadblock-type 1 ISO PID PID:200227 NCBI chr 3:143,742,427...143,764,227
Ensembl chr 3:143,742,586...143,764,227
JBrowse link
G Eif2a eukaryotic translation initiation factor 2A ISO PID PID:200227 NCBI chr 2:142,761,303...142,794,767
Ensembl chr 2:142,761,416...142,795,068
JBrowse link
G Fkbp1a FKBP prolyl isomerase 1A ISO PID
RGD
PMID:12809600 PID:200227, RGD:2298922 NCBI chr 3:140,040,359...140,060,107
Ensembl chr 3:140,040,278...140,060,743
JBrowse link
G Foxh1 forkhead box H1 ISO RGD PMID:18061509 PMID:16322555 RGD:5143919, RGD:2302137 NCBI chr 7:108,387,969...108,391,566
Ensembl chr 7:108,387,969...108,390,049
JBrowse link
G Foxo1 forkhead box O1 ISO RGD PMID:18061509 PMID:16322555 RGD:5143919, RGD:2302137 NCBI chr 2:136,312,168...136,390,603
Ensembl chr 2:136,312,168...136,387,790
JBrowse link
G Foxo3 forkhead box O3 ISO RGD PMID:18061509 PMID:16322555 RGD:5143919, RGD:2302137 NCBI chr20:45,669,708...45,764,606
Ensembl chr20:45,672,995...45,764,561
JBrowse link
G Foxo4 forkhead box O4 ISO RGD PMID:18061509 PMID:16322555 RGD:5143919, RGD:2302137 NCBI chr  X:66,385,241...66,392,115
Ensembl chr  X:66,385,558...66,392,115
JBrowse link
G Grb2 growth factor receptor bound protein 2 ISO PID PID:200227 NCBI chr10:100,881,404...100,949,193
Ensembl chr10:100,869,718...100,949,309
JBrowse link
G Itch itchy E3 ubiquitin protein ligase ISO PID PID:200227 NCBI chr 3:143,642,348...143,733,745
Ensembl chr 3:143,645,637...143,733,543
JBrowse link
G Map3k7 mitogen activated protein kinase kinase kinase 7 ISO PID PID:200227 NCBI chr 5:46,356,973...46,415,597
Ensembl chr 5:46,357,931...46,415,597
JBrowse link
G Nedd4l NEDD4 like E3 ubiquitin protein ligase ISO PID PID:200227 NCBI chr18:58,393,759...58,726,709
Ensembl chr18:58,393,509...58,723,137
JBrowse link
G Ocln occludin ISO PID PID:200227 NCBI chr 2:31,657,217...31,707,466
Ensembl chr 2:31,657,220...31,764,150
JBrowse link
G Pard6a par-6 family cell polarity regulator alpha ISO PID PID:200227 NCBI chr19:33,589,531...33,591,900
Ensembl chr19:33,589,542...33,591,900
JBrowse link
G Pdpk1 3-phosphoinositide dependent protein kinase-1 ISO PID PID:200227 NCBI chr10:13,105,435...13,182,664
Ensembl chr10:13,105,498...13,174,623
JBrowse link
G Pml PML nuclear body scaffold ISO PID PID:200227 NCBI chr 8:58,627,347...58,661,927
Ensembl chr 8:58,628,837...58,658,971
JBrowse link
G Ppp1ca protein phosphatase 1 catalytic subunit alpha ISO PID PID:200227 NCBI chr 1:201,485,117...201,488,734
Ensembl chr 1:201,485,085...201,497,327
JBrowse link
G Ppp1r15a protein phosphatase 1, regulatory subunit 15A ISO PID PID:200227 NCBI chr 1:96,000,053...96,003,128
Ensembl chr 1:96,000,058...96,003,171
JBrowse link
G Ppp2ca protein phosphatase 2 catalytic subunit alpha ISO PID PID:200227 NCBI chr10:36,358,110...36,377,864
Ensembl chr10:36,358,101...36,377,862
JBrowse link
G Ppp2cb protein phosphatase 2 catalytic subunit beta ISO PID PID:200227 NCBI chr16:58,558,119...58,579,325
Ensembl chr16:58,558,122...58,579,576
JBrowse link
G Ppp2r2a protein phosphatase 2, regulatory subunit B, alpha ISO PID PID:200227 NCBI chr15:41,204,659...41,263,924
Ensembl chr15:41,204,200...41,263,924
JBrowse link
G Rhoa ras homolog family member A ISO PID PID:200227 NCBI chr 8:108,991,926...109,025,746
Ensembl chr 8:108,991,954...109,025,746
JBrowse link
G Rnf111 ring finger protein 111 ISO PID PID:200227 NCBI chr 8:71,103,967...71,180,172
Ensembl chr 8:71,103,973...71,145,070
JBrowse link
G Rps6kb1 ribosomal protein S6 kinase B1 ISO PID PID:200227 NCBI chr10:71,323,777...71,367,908
Ensembl chr10:71,323,777...71,367,908
JBrowse link
G Runx1 RUNX family transcription factor 1 IMP RGD PMID:18061509 PMID:16322555 RGD:5143919, RGD:2302137 NCBI chr11:31,839,880...32,074,427
Ensembl chr11:31,843,764...32,074,542
JBrowse link
G Runx2 RUNX family transcription factor 2 ISO RGD PMID:18061509 PMID:16322555 RGD:5143919, RGD:2302137 NCBI chr 9:16,167,504...16,492,826
Ensembl chr 9:16,167,482...16,492,167
JBrowse link
G Runx3 RUNX family transcription factor 3 ISO RGD PMID:18061509 PMID:16322555 RGD:5143919, RGD:2302137 NCBI chr 5:147,360,587...147,419,161
Ensembl chr 5:147,360,994...147,419,156
JBrowse link
G Shc1 SHC adaptor protein 1 ISO PID PID:200227 NCBI chr 2:174,837,937...174,849,538
Ensembl chr 2:174,837,930...174,849,536
JBrowse link
G Skil SKI-like proto-oncogene ISO PID PID:200227 NCBI chr 2:112,247,047...112,275,176
Ensembl chr 2:112,247,051...112,275,080
JBrowse link
G Smad2 SMAD family member 2 IDA
ISO
IMP
PID
RGD
PMID:16959941 PMID:12809600 PMID:18684975 PID:200227, RGD:1599906, RGD:2298922, RGD:2302517 NCBI chr18:69,849,884...69,918,926
Ensembl chr18:69,850,377...69,912,323
JBrowse link
G Smad3 SMAD family member 3 ISO
IDA
IMP
PID
RGD
PMID:12809600 PMID:12702545 PMID:16891311 PID:200227, RGD:2298922, RGD:1299323, RGD:1625706 NCBI chr 8:64,126,829...64,236,960
Ensembl chr 8:64,110,039...64,236,960
JBrowse link
G Smad4 SMAD family member 4 IDA
ISO
PID
RGD
PMID:16959941 PMID:12809600 PID:200227, RGD:1599906, RGD:2298922 NCBI chr18:67,243,742...67,274,438
Ensembl chr18:67,243,742...67,274,438
JBrowse link
G Smad7 SMAD family member 7 ISO PID
RGD
PMID:12809600 PID:200227, RGD:2298922 NCBI chr18:68,988,429...69,016,774
Ensembl chr18:68,988,429...69,016,765
JBrowse link
G Smurf1 SMAD specific E3 ubiquitin protein ligase 1 ISO PID
RGD
PMID:12809600 PID:200227, RGD:2298922 NCBI chr12:9,635,009...9,726,520
Ensembl chr12:9,635,025...9,726,519
JBrowse link
G Smurf2 SMAD specific E3 ubiquitin protein ligase 2 ISO PID
RGD
PMID:12809600 PID:200227, RGD:2298922 NCBI chr10:91,761,798...91,862,485
Ensembl chr10:91,761,807...91,862,488
JBrowse link
G Sos1 SOS Ras/Rac guanine nucleotide exchange factor 1 ISO PID PID:200227 NCBI chr 6:14,533,870...14,613,348
Ensembl chr 6:14,533,360...14,611,107
JBrowse link
G Sptbn1 spectrin, beta, non-erythrocytic 1 ISO PID PID:200227 NCBI chr14:103,841,713...104,016,900
Ensembl chr14:103,842,684...104,008,507
JBrowse link
G Strap serine/threonine kinase receptor associated protein ISO PID PID:200227 NCBI chr 4:170,646,042...170,660,291
Ensembl chr 4:170,646,001...170,660,828
JBrowse link
G Tab1 TGF-beta activated kinase 1/MAP3K7 binding protein 1 ISO PID PID:200227 NCBI chr 7:111,675,829...111,707,058
Ensembl chr 7:111,686,371...111,707,058
JBrowse link
G Tab2 TGF-beta activated kinase 1/MAP3K7 binding protein 2 ISO PID PID:200227 NCBI chr 1:2,375,026...2,425,115
Ensembl chr 1:2,375,490...2,424,756
JBrowse link
G Tgfb1 transforming growth factor, beta 1 ISO PID
RGD
PMID:15109563 PID:200227, RGD:2298921 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
JBrowse link
G Tgfb2 transforming growth factor, beta 2 ISO PID
RGD
PMID:15109563 PID:200227, RGD:2298921 NCBI chr13:98,160,075...98,261,771
Ensembl chr13:98,160,087...98,261,405
JBrowse link
G Tgfb3 transforming growth factor, beta 3 ISO PID
RGD
PMID:12809600 PID:200227, RGD:2298922 NCBI chr 6:105,704,058...105,726,661
Ensembl chr 6:105,704,236...105,726,564
JBrowse link
G Tgfbr1 transforming growth factor, beta receptor 1 ISO
IMP
RGD PMID:12809600 PMID:18684975 RGD:2298922, RGD:2302517 NCBI chr 5:61,653,773...61,710,777
Ensembl chr 5:61,653,233...61,710,777
JBrowse link
G Tgfbr2 transforming growth factor, beta receptor 2 ISO
IMP
PID
RGD
PMID:15109563 PMID:14729511 PMID:18684975 PID:200227, RGD:2298921, RGD:1579921, RGD:2302517 NCBI chr 8:115,794,537...115,883,615
Ensembl chr 8:115,794,537...115,883,228
JBrowse link
G Tgfbr3 transforming growth factor beta receptor 3 ISO PID
RGD
PMID:12809600 PID:200227, RGD:2298922 NCBI chr14:2,489,397...2,665,383
Ensembl chr14:2,489,397...2,663,341
JBrowse link
G Tgfbrap1 transforming growth factor, beta receptor associated protein 1 ISO PID PID:200227 NCBI chr 9:45,320,975...45,371,329
Ensembl chr 9:45,320,930...45,371,311
JBrowse link
G Wwp1 WW domain containing E3 ubiquitin protein ligase 1 ISO PID PID:200227 NCBI chr 5:33,092,379...33,185,887
Ensembl chr 5:33,098,494...33,186,046
JBrowse link
G Xiap X-linked inhibitor of apoptosis ISO PID PID:200227 NCBI chr  X:120,890,537...120,938,413
Ensembl chr  X:120,897,907...120,934,700
JBrowse link
G Yap1 Yes1 associated transcriptional regulator ISO PID PID:200227 NCBI chr 8:5,095,705...5,166,808
Ensembl chr 8:5,095,722...5,167,010
JBrowse link
G Ywhae tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon ISO PID PID:200227 NCBI chr10:60,584,665...60,622,352
Ensembl chr10:60,584,652...60,671,589
JBrowse link
G Zfyve16 zinc finger FYVE-type containing 16 ISO PID PID:200227 NCBI chr 2:23,713,018...23,757,576
Ensembl chr 2:23,713,766...23,756,990
JBrowse link
G Zfyve9 zinc finger FYVE-type containing 9 ISO PID
RGD
PMID:12809600 PID:200227, RGD:2298922 NCBI chr 5:123,370,677...123,529,699
Ensembl chr 5:123,370,677...123,529,699
JBrowse link
altered transforming growth factor-beta Smad dependent signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Smad2 SMAD family member 2 ISO RGD PMID:17613544 PMID:18662538 RGD:2306282, RGD:2308865 NCBI chr18:69,849,884...69,918,926
Ensembl chr18:69,850,377...69,912,323
JBrowse link
G Smad3 SMAD family member 3 ISO RGD PMID:17613544 PMID:18772397 RGD:2306282, RGD:5490966 NCBI chr 8:64,126,829...64,236,960
Ensembl chr 8:64,110,039...64,236,960
JBrowse link
G Smad4 SMAD family member 4 ISO RGD PMID:17613544 PMID:18662538 PMID:18772397 PMID:19506583 RGD:2306282, RGD:2308865, RGD:5490966, RGD:5490965 NCBI chr18:67,243,742...67,274,438
Ensembl chr18:67,243,742...67,274,438
JBrowse link
G Smad7 SMAD family member 7 ISO RGD PMID:18662538 RGD:2308865 NCBI chr18:68,988,429...69,016,774
Ensembl chr18:68,988,429...69,016,765
JBrowse link
G Tgfb1 transforming growth factor, beta 1 ISO RGD PMID:18313409 PMID:17613544 RGD:2299005, RGD:2306282 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
JBrowse link
G Tgfbr1 transforming growth factor, beta receptor 1 ISO RGD PMID:18313409 PMID:17613544 RGD:2299005, RGD:2306282 NCBI chr 5:61,653,773...61,710,777
Ensembl chr 5:61,653,233...61,710,777
JBrowse link
G Tgfbr2 transforming growth factor, beta receptor 2 ISO RGD PMID:18313409 PMID:17613544 PMID:18662538 PMID:18772397 PMID:19506583 RGD:2299005, RGD:2306282, RGD:2308865, RGD:5490966, RGD:5490965 NCBI chr 8:115,794,537...115,883,615
Ensembl chr 8:115,794,537...115,883,228
JBrowse link

Altered Pathway:

Additional Elements in Pathway:

(includes Gene Groups, Small Molecules, Other Pathways..etc.)
Object TypePathway ObjectPathway Object Description
Gene Grouptranscription factors/co-activatorstranscription factors/co-activators associated with Smad2/3-4
Gene GroupTgf-beta target genestransforming growth factor, beta target genes

Pathway Gene Annotations

Disease Annotations Associated with Genes in the transforming growth factor-beta Smad dependent signaling pathway
Disease TermsGene Symbols
abdominal aortic aneurysmCav1
Aberrant Crypt FociCtnnb1 , Tgfb2
Abnormalities, Drug-InducedRhoa
acoustic neuromaCav1
Acro-OsteolysisSmad4
acromicric dysplasiaSmad2 , Tgfb1
actinic keratosisTgfb1
acute kidney failureA2m , Ocln , Tgfb1 , Tgfbr1
Acute Lung InjuryCav1 , Tgfb1
acute lymphoblastic leukemiaCrebbp , Runx1
acute megakaryocytic leukemiaRunx1
acute myeloid leukemiaCrebbp , Foxo1 , Runx1 , Runx3
acute myocardial infarctionRhoa
acute promyelocytic leukemiaPml
Acute-On-Chronic Liver FailurePpp1r15a
adenocarcinomaCcn2 , Ctnnb1 , Runx3 , Strap , Tgfb1
adenoid cystic carcinomaCrebbp , Foxo3
adenomaCtnnb1
adenylosuccinase lyase deficiencyTab1
Adrenal Gland NeoplasmsCtnnb1
adrenocortical carcinomaCtnnb1 , Daxx , Xiap
Agenesis of Corpus CallosumCrebbp
Aggressive FibromatosisCcn2 , Ctnnb1
agnathia-otocephaly complexFoxh1
Aicardi-Goutieres Syndrome 1Rhoa
Aicardi-Goutieres Syndrome 3Ppp1ca
Alazami SyndromeCtnnb1
AlbuminuriaShc1
alcohol dependenceArrb2 , Creb1
alcohol use disorderCreb1 , Crebbp
alcohol-induced mental disorderFoxo4
Alcoholic Fatty LiverArrb2 , Foxo1
alcoholic liver cirrhosisSmad3 , Tgfb1
Alcoholic Liver DiseasesCav1
allergic conjunctivitisTgfb1
allergic diseaseTgfb1
allergic rhinitisOcln , Tgfb1
alopeciaRhoa
alveolar rhabdomyosarcomaFoxo1
Alzheimer's diseaseA2m , Camk2a , Cav1 , Crebbp , Ctnnb1 , Foxo3 , Runx1 , Shc1
Amaurosis FugaxPpp1r15a
amenorrheaOcln
amnestic disorderCreb1
amphetamine abuseArrb2 , Creb1
amyotrophic lateral sclerosisPpp1r15a , Runx1
amyotrophic lateral sclerosis type 1Crebbp , Runx1 , Shc1 , Xiap
anaplastic ependymomaRunx1
AnetodermaTgfb1
AneurysmSmad3
Angiomatoid Fibrous HistiocytomaCreb1
angiosarcomaCtnnb1
Animal Disease ModelsCtnnb1 , Rhoa , Tgfbr1
ankylosing spondylitisRunx3
anogenital venereal wartTgfb1
anxiety disorderCreb1
aortic aneurysmSmad3 , Tgfb2 , Tgfbr1 , Tgfbr2
aortic diseaseSmad3 , Smad4 , Tgfb2 , Tgfbr1
aortic dissectionSmad3
aortic valve disease 2Smad3
aortic valve insufficiencyCcn2 , Tgfb1 , Tgfb2
aortic valve stenosisBambi
aphthous stomatitisTgfb1
aplastic anemiaTgfb1
appendiceal neoplasmDaxx
arrhythmogenic right ventricular cardiomyopathySos1 , Tgfb3
arrhythmogenic right ventricular dysplasia 1Tgfb3
Arsenic PoisoningSkil
ARTERIAL DISSECTIONSmad3
arteriosclerosisMap3k7 , Tgfb1 , Tgfbr2
Arteriovenous FistulaArrb2
arteriovenous malformations of the brainZfyve16
asphyxiating thoracic dystrophyYap1
asthmaDcn , Ppp2ca , Rhoa , Runx1 , Runx3 , Tgfb1
ataxia telangiectasiaYap1
atherosclerosisCav1 , Ctnnb1
atopic dermatitisTgfb1
atrial fibrillationCav1 , Smad7 , Tgfb1
atrial heart septal defectCrebbp , Sos1
atrial heart septal defect 1Tgfb2
Atrial Septal Defect, Secundum TypeSos1
AtrophyRps6kb1
atypical chronic myeloid leukemiaRunx1
Au-Kline SyndromeCrebbp
autism spectrum disorderCamk2a , Creb1 , Crebbp , Ctnnb1 , Nedd4l
autistic disorderFoxo4 , Xiap
autoimmune diseaseRunx1 , Tgfb2
autoimmune hepatitisTgfb1
autoimmune thrombocytopenic purpuraTgfb1
autosomal dominant dyskeratosis congenita 1Skil
autosomal dominant dyskeratosis congenita 6Pard6a
autosomal dominant intellectual developmental disorder 19Ctnnb1
autosomal dominant intellectual developmental disorder 5Daxx
autosomal dominant intellectual developmental disorder 53Camk2a
autosomal dominant intellectual developmental disorder 7Runx1
autosomal dominant polycystic kidney diseaseRps6kb1
autosomal recessive intellectual developmental disorder 63Camk2a
autosomal recessive limb-girdle muscular dystrophy type 2PRhoa
B-lymphoblastic leukemia/lymphomaCcn2 , Runx1
background diabetic retinopathyA2m
bacterial pneumoniaTgfb1
Bardet-Biedl syndromePml
Barth syndromeFkbp1a
basal cell carcinomaCav1 , Tgfb2
Beckwith-Wiedemann syndromeSptbn1
Behcet's diseaseTgfb1
benign hypertensive renal diseaseMap3k7
berylliosisTgfb1
Bile Duct NeoplasmsRunx3
biliary atresiaTgfb1
bipolar disorderCamk2a
blood platelet diseaseRunx1
Bloom syndromePml , Rnf111 , Smad3
bone development diseaseTgfb2
bone diseaseCcn2 , Tgfbr2
Bone FracturesRunx1 , Runx2 , Sptbn1 , Tgfbr2
Bone NeoplasmsTgfbr2
borna diseaseEif2a
brachydactylySmad4
brain diseaseTab2 , Tgfb1
brain edemaMap3k7
Brain Hypoxia-IschemiaDaxx , Foxo3 , Map3k7
brain infarctionArrb2
Brain InjuriesMap3k7 , Rhoa
brain ischemiaCav1 , Creb1 , Map3k7 , Ppp1r15a , Sos1 , Tgfb1
Brain NeoplasmsCtnnb1 , Tgfbr2 , Yap1
breast cancerCav1 , Grb2 , Rhoa , Runx3 , Smad4 , Tgfb1 , Xiap
breast carcinomaCav1 , Dcn , Rhoa , Smad2 , Xiap
breast ductal carcinomaPml , Xiap
Breast NeoplasmsCav1 , Ctnnb1 , Ocln , Pdpk1 , Rhoa , Runx2 , Shc1 , Smad4 , Wwp1 , Yap1
Brown-Vialetto-Van Laere syndrome 2Foxh1
Brugada syndromeSos1 , Tgfb3
Brugada syndrome 8Pml
BurnsA2m , Ocln , Rps6kb1
CachexiaMap3k7 , Tgfb1
Cafe au lait Spots, MultipleSos1
calcinosisCtnnb1 , Tgfb1
Camurati-Engelmann diseaseTgfb1
CarcinogenesisCav1
carcinomaRhoa , Tgfb1 , Tgfbr2
carcinosarcomaTgfb1
Cardiac FibrosisMap3k7 , Tgfb1
CardiomegalyA2m , Atf3 , Bambi , Cav1 , Map3k7 , Rhoa , Rps6kb1 , Shc1 , Tgfb1
cardiomyopathyAtf3 , Runx1 , Sos1 , Tab2 , Tgfb3
carotid artery diseaseTgfb1
Carotid Artery InjuriesCcn2 , Foxo3 , Tgfb1 , Tgfb3 , Tgfbr1 , Tgfbr2
Carpenter Syndrome 2Tgfb1
Caudal Duplication AnomalyAxin1
Cecal NeoplasmsCtnnb1
celiac diseaseRunx3
cerebral infarctionA2m , Sos1
cervical cancerSmad2 , Smad4 , Sos1
cervical squamous cell carcinomaSmad3
cervix uteri carcinoma in situXiap
Charcot-Marie-Tooth disease type 2Shc1
Charcot-Marie-Tooth disease type 4Foxo3
Charlevoix-Saguenay spastic ataxiaTgfbr1
Chediak-Higashi syndromeXiap
Chemical and Drug Induced Liver InjuryCtnnb1 , Shc1 , Tgfb1 , Tgfbr1
chlamydiaTgfb1
cholangiocarcinomaRunx3 , Smad4 , Tgfb1 , Tgfbr2
cholangitisTgfb2
chorioamnionitisTgfb1
choroid plexus carcinomaFoxo3
Chromosomal InstabilityPpp2r2a
chromosome 16q22 deletion syndromePard6a
chromosome 17p13.3 duplication syndromeYwhae
Chronic Allograft NephropathyCcn2
Chronic Experimental PancreatitisTgfb1
Chronic HepatitisShc1 , Smad2 , Tgfb1
Chronic Hepatitis BCcn2 , Ppp1r15a , Tgfb1
Chronic Hepatitis CSmad4
chronic kidney diseaseMap3k7
chronic myeloid leukemiaSmad4 , Tgfb1
chronic obstructive pulmonary diseaseBambi , Ccn2 , Foxo3 , Map3k7 , Smad4 , Tab2 , Tgfb1
CicatrixSmad4
clear cell adenocarcinomaDaxx
clear cell renal cell carcinomaPml , Xiap
cleft palateNedd4l , Tgfb1 , Tgfb2 , Tgfb3
cleft soft palateTgfbr2
cleidocranial dysplasiaRunx2
cocaine abuseCreb1
cocaine dependenceCreb1
Cocaine-Related DisordersCamk2a , Creb1 , Rhoa , Runx2 , Smad3 , Smurf1
cognitive disorderSmad4
colobomaYap1
colon adenocarcinomaCtnnb1 , Daxx , Tgfb1
colon cancerAxin1 , Rps6kb1 , Smad2 , Smad4 , Tgfb1 , Tgfb3 , Tgfbr2
colon carcinomaCtnnb1 , Smad4 , Tgfb1 , Tgfb2
colon signet ring adenocarcinomaRunx1
Colonic NeoplasmsA2m , Ctnnb1 , Runx3 , Tgfbr2
colorectal adenocarcinomaRunx1
colorectal adenomaSmad4
colorectal cancerBambi , Ctnnb1 , Pml , Rhoa , Rnf111 , Runx1 , Runx2 , Runx3 , Smad3 , Smad4 , Smad7 , Tgfb1 , Tgfb2 , Tgfb3 , Tgfbr1 , Tgfbr2 , Xiap , Yap1
colorectal carcinomaSmad4 , Strap
Colorectal NeoplasmsAxin1 , Crebbp , Ctnnb1 , Rhoa , Runx3 , Smad3 , Smad4 , Smad7 , Strap , Tgfb1 , Tgfb2 , Tgfbr1 , Yap1
cone dystrophyYap1
congenital diaphragmatic herniaCcn2 , Rhoa
congenital disorder of glycosylation IiTgfbr1
congenital disorder of glycosylation type IITgfbr1
congenital generalized lipodystrophy type 3Cav1
Congenital Heart Defects, Multiple TypesTab2
Congenital Heart Defects, Multiple Types, 2Tab2
CONGENITAL HEART DEFECTS, MULTIPLE TYPES, 8, WITH OR WITHOUT HETEROTAXYSmad2
congenital heart diseaseFkbp1a , Sos1 , Tab2 , Tgfb2
congenital hypoplastic anemiaTgfb1
congenital hypothyroidismRunx2
Congenital Limb DeformitiesTgfb2
congenital muscular dystrophy-dystroglycanopathy type A8Ctnnb1
congenital myasthenic syndrome 14Tgfbr1
congenital stromal corneal dystrophyDcn
congestive heart failureBambi , Ccn2 , Creb1 , Foxo1 , Map3k7 , Pdpk1 , Ppp1ca , Ppp2ca
connective tissue diseaseSmad3 , Tgfb2 , Tgfbr1 , Tgfbr2 , Tgfbr3
Conotruncal Cardiac DefectsFoxh1
contact dermatitisCcn2
ContractureTgfb3
Copper-Overload CirrhosisSmad2 , Tgfb1
coronary artery diseaseMap3k7 , Smad3 , Tgfb1
COVID-19A2m , Runx3 , Tgfbr3
cranioectodermal dysplasiaTgfb3
Craniofacial AbnormalitiesCtnnb1 , Rhoa , Runx2 , Smad2 , Smad3 , Smad4 , Tgfb2 , Tgfbr2
CRANIOMETADIAPHYSEAL OSTEOSCLEROSIS WITH HIP DYSPLASIAAxin1
craniopharyngiomaCtnnb1
craniosynostosisTgfb1 , Tgfbr1
Craniosynostosis Syndrome, Autosomal RecessiveRunx2 , Tgfbr1
Crohn's diseaseOcln , Smad3
Cronkhite-Canada syndromeSmad4
CyanosisTgfb2
cystic fibrosisCav1 , Tgfb1
DeafnessSmad4
degenerative disc diseaseTgfb1
demyelinating diseasePpp1r15a
depressive disorderCreb1
Dermal FibrosisCav1
dermoid cyst of ovaryFoxo3
desmoid tumorCtnnb1
developmental and epileptic encephalopathy 1Pdpk1
DEVELOPMENTAL DELAY, IMPAIRED SPEECH, AND BEHAVIORAL ABNORMALITIESSptbn1
Developmental DisabilitiesCamk2a , Crebbp , Ctnnb1 , Ocln
Developmental DiseaseCtnnb1 , Nedd4l , Sptbn1 , Tgfb3
developmental disorder of mental healthRunx3
dextrocardiaZfyve16
diabetes mellitusCav1 , Tgfb1
Diabetic CardiomyopathiesA2m , Ctnnb1 , Map3k7
Diabetic NephropathiesCav1 , Ccn2 , Creb1 , Dcn , Rhoa , Tgfb1 , Tgfbr2
diabetic neuropathyCav1 , Tgfb1 , Tgfb2 , Tgfb3
diabetic retinopathyCcn2 , Ocln , Tgfbr2
Diamond-Blackfan anemiaTgfb1 , Tgfbr3
Diaphragmatic HerniaTgfb1
diffuse large B-cell lymphomaCrebbp , Foxo1 , Pdpk1 , Rps6kb1 , Smurf2
diffuse sclerodermaCav1 , Tgfbr1
DiGeorge syndromeTgfbr2
Digestive System NeoplasmsRunx3
Dilatation, PathologicTgfb1
dilated cardiomyopathyCreb1 , Ctnnb1 , Map3k7 , Nedd4l , Ppp1ca , Rps6kb1 , Sos1 , Tab2 , Tgfb3
diseaseCtnnb1
disease by infectious agentXiap
disease of cellular proliferationCtnnb1 , Ocln
Disease ProgressionCtnnb1 , Yap1
Disproportionate Tall StatureTgfbr1
Dissecting AneurysmSmad3 , Tgfbr1 , Tgfbr2
drug dependenceCreb1
drug psychosisArrb2
dry eye syndromeTgfb1
Duchenne muscular dystrophyTgfb1
duodenal ulcerTgfb1
DwarfismCcn2 , Sos1
DyslipidemiasPml
ectodermal dysplasiaRhoa
ECTODERMAL DYSPLASIA WITH FACIAL DYSMORPHISM AND ACRAL, OCULAR, AND BRAIN ANOMALIESRhoa
Ehlers-Danlos syndromeDcn , Smad3 , Tgfb1 , Tgfb2 , Tgfbr1 , Tgfbr2
Ehlers-Danlos syndrome classic type 1Tgfbr1
Embryo LossFoxo3 , Map3k7 , Tab2
embryonal rhabdomyosarcomaYap1
EmphysemaPpp1r15a , Ppp2r2a
end stage renal diseaseTgfb1
endodermal sinus tumorCtnnb1
endometrial adenocarcinomaFoxo3 , Tgfbr3
endometrial cancerRunx1 , Smad2 , Smad3 , Smad7
endometrial carcinomaGrb2 , Runx3 , Smad4
Endometrial Intraepithelial NeoplasiaCtnnb1
Endometrial NeoplasmsCtnnb1 , Dcn
Endometrioid CarcinomasCtnnb1 , Daxx
endometriosisCtnnb1 , Nedd4l , Runx1 , Tgfb2
endomyocardial fibrosisCcn2 , Tgfb1
eosinophilic esophagitisTgfb1
epidermolysis bullosa simplex with muscular dystrophyFoxh1
epilepsyAxin1 , Crebbp , Nedd4l , Pdpk1 , Tgfb1
esophageal cancerTgfbr2
esophageal carcinomaCtnnb1 , Rhoa , Smad4
Esophageal NeoplasmsRunx3 , Tgfbr2 , Xiap
esophagus adenocarcinomaSmad4
esophagus squamous cell carcinomaAxin1 , Crebbp , Ctnnb1 , Fkbp1a , Runx1 , Runx2 , Runx3 , Tgfbr2
essential hypertensionOcln
essential thrombocythemiaTgfb1
exfoliation syndromeCav1
Experimental ArthritisA2m , Arrb2 , Tgfb1 , Tgfbr2
Experimental Autoimmune EncephalomyelitisA2m , Foxo3 , Rhoa , Tgfb1 , Tgfb2
Experimental Autoimmune MyocarditisCav1
Experimental Autoimmune NeuritisCav1 , Rhoa
Experimental ColitisSmad4
Experimental Diabetes MellitusAtf3 , Cav1 , Ccn2 , Dcn , Foxo3 , Rhoa , Tgfb1 , Tgfb2
Experimental LeukemiaRunx1
Experimental Liver CirrhosisA2m , Arrb2 , Atf3 , Cav1 , Ccn2 , Creb1 , Fkbp1a , Foxo1 , Rhoa , Skil , Smad2 , Smad3 , Smad4 , Tgfb1 , Tgfb3 , Tgfbr1 , Tgfbr2 , Zfyve16
Experimental Liver NeoplasmsArrb2 , Ctnnb1 , Pml , Ppp2ca , Tgfb1
Experimental Mammary NeoplasmsCav1 , Ctnnb1 , Runx1 , Tgfb1 , Tgfbr1 , Tgfbr2 , Xiap
Experimental NeoplasmsCtnnb1
Experimental Radiation InjuriesCcn2
extrahepatic cholestasisCcn2 , Map3k7 , Tgfb1
exudative vitreoretinopathyCtnnb1
exudative vitreoretinopathy 1Ctnnb1
exudative vitreoretinopathy 7Ctnnb1
Eye AbnormalitiesTgfb2 , Tgfbr2
facioscapulohumeral muscular dystrophyDcn
factor VIII deficiencyTgfb1
familial adenomatous polyposis 1Camk2a , Ppp2ca
familial hyperlipidemiaShc1 , Tgfb1
familial hypertrophic cardiomyopathySos1
familial partial lipodystrophyCav1
Familial Partial Lipodystrophy Type 7Cav1
Familial Platelet Disorder with Associated Myeloid MalignancyRunx1
Familial Thoracic Aortic Aneurysm 1Smad3 , Tgfbr2
Familial Thoracic Aortic Aneurysm 6Smad3 , Tgfbr1
Fanconi syndromeSkil
FatigueTgfbr2
Female InfertilityCcn2
female reproductive system diseaseSmad2
Femur Head NecrosisA2m
Ferguson-Smith tumorTgfbr1
fetal alcohol syndromeRhoa
FeverA2m , Ccn2
FG Syndrome 1Foxo4
fibrolamellar carcinomaCtnnb1
FibrosisCcn2 , Ctnnb1 , Dcn , Rhoa , Tgfb1
focal segmental glomerulosclerosisCcn2 , Tgfb1
follicular lymphomaCrebbp
Forney Robinson Pascoe SyndromeMap3k7
frontometaphyseal dysplasiaMap3k7
frontometaphyseal dysplasia 2Map3k7
gallbladder cancerCtnnb1 , Smad4
Gallbladder NeoplasmsRunx3 , Tgfb1
GallstonesSmad4
gastric adenocarcinomaCrebbp , Ctnnb1 , Rhoa , Smad4 , Xiap
gastric ulcerFoxo4
Gastro-Enteropancreatic Neuroendocrine TumorDaxx , Runx3
gastrointestinal stromal tumorAtf3 , Shc1 , Tgfb2 , Tgfbr2
gastrointestinal system cancerSmad4
Generalized Arterial Calcification of Infancy, 1Ccn2
genetic diseaseCamk2a , Cav1 , Crebbp , Ctnnb1 , Dcn , Foxh1 , Itch , Map3k7 , Nedd4l , Ocln , Ppp2ca , Rhoa , Runx1 , Runx2 , Smad2 , Sos1 , Sptbn1 , Tab2 , Tgfb1 , Tgfb2 , Tgfbr2 , Xiap
Germ Cell and Embryonal NeoplasmsRhoa
gestational diabetesCcn2 , Dcn
gingival fibromatosisSos1
Gingival Fibromatosis 1Sos1
glaucomaCrebbp , Tgfb2
glioblastomaArrb2 , Crebbp , Pml , Runx1 , Runx3
glomerulosclerosisShc1
glutathione synthetase deficiencyDynlrb1 , Itch
glycine encephalopathyRhoa
glycogen storage disease XVEif2a
GM1 gangliosidosis type 1Ctnnb1
goutTgfb1
granulosa cell tumorCtnnb1
Graves' diseaseTgfb1
Growth Mental Deficiency Syndrome of MyhreSmad4
Habitual AbortionsFoxo3
head and neck squamous cell carcinomaCrebbp , Ctnnb1 , Rhoa , Smad4 , Yap1
Hearing Loss, Cisplatin-InducedCamk2a
heart diseaseA2m , Ppp2ca , Tgfb1
Heart InjuriesTgfb1
Heavy Metal ToxicityDaxx
hemangiomaFoxo1 , Foxo3 , Foxo4 , Yap1
hemolytic anemiaA2m
HemorrhageCav1
hemorrhagic diseaseRunx1 , Smad4
Hemorrhagic ShockTgfb1
hepatic encephalopathyTgfb1
Hepatic InsufficiencyTgfb1
hepatic veno-occlusive diseaseOcln
hepatitis BCtnnb1
hepatoblastomaCtnnb1 , Tgfbr2
hepatocellular adenomaA2m , Ctnnb1
hepatocellular carcinomaA2m , Arrb2 , Axin1 , Crebbp , Ctnnb1 , Dcn , Dynlrb1 , Foxo1 , Pml , Runx1 , Runx3 , Shc1 , Smad2 , Smad4 , Smad7 , Tgfb1 , Tgfb2 , Tgfbr2 , Yap1
HepatomegalyCamk2a , Tgfb1
hereditary breast ovarian cancer syndromePpp2r2a , Smad4 , Smad7
hereditary desmoid diseaseCtnnb1
hereditary hemorrhagic telangiectasiaSmad4
Hereditary Hemorrhagic Telangiectasia, Type 1Smad4 , Tgfb1
Hereditary Neoplastic SyndromesCamk2a , Ppp2ca , Runx1 , Smad4
hereditary nonpolyposis colorectal cancer type 6Tgfbr2
heroin dependenceArrb2 , Creb1
Heterotopic OssificationRunx2 , Smad4
high grade ependymomaRunx1
high grade gliomaCamk2a , Cav1 , Dcn
Hirschsprung Disease 1Crebbp , Tgfb2
Hirschsprung's diseaseCrebbp , Tgfb2 , Ywhae
holoprosencephalyCreb1 , Foxh1
Holt-Oram syndromeTgfb2
Human InfluenzaAtf3
Human Viral HepatitisSmad4
Huntington's diseaseCreb1 , Crebbp
HyperalgesiaCamk2a , Ppp2ca , Tgfbr1
hyperekplexiaCtnnb1
hyperglycemiaShc1
hyperinsulinismRps6kb1
hyperkalemic periodic paralysisSmurf2
hypermethioninemia with deficiency of S-adenosylhomocysteine hydrolaseItch
HyperoxaluriaRunx2
HyperoxiaTgfb1
HyperplasiaCav1 , Tgfb1 , Tgfbr2
hypertensionArrb2 , Cav1 , Ccn2 , Creb1 , Nedd4l , Rhoa , Rps6kb1 , Tgfb1 , Tgfb3
Hypertensive NephropathyShc1
hypertrophic cardiomyopathyCav1 , Ctnnb1 , Map3k7 , Sos1 , Tgfb1 , Tgfb3
hypertrophic cardiomyopathy 1Sos1
hyperuricemiaTgfb1
HypoalbuminemiaA2m
Hypoglossal Nerve InjuriesSmad2 , Smad3 , Smad4 , Smad7
hypoglycemiaCreb1
HypopigmentationRhoa
HypoproteinemiaRps6kb1
hypospadiasAtf3 , Nedd4l
hypothyroidismCav1
idiopathic generalized epilepsyAxin1 , Crebbp , Pdpk1
idiopathic pulmonary fibrosisSmad2
idiopathic scoliosisRunx3
IgA glomerulonephritisTgfb1
Immunoblastic LymphadenopathyRhoa
immunodeficiency 12Nedd4l
immunodeficiency 28Runx1
immunodeficiency 42Shc1
imperforate anusCtnnb1
impotenceTgfb1
in situ carcinomaCtnnb1 , Runx3
Infant, Newborn, DiseasesTgfb1
infertilityTgfbr3
InflammationA2m , Camk2a , Tgfb1
inflammatory bowel diseaseRunx3 , Tgfb1
INFLAMMATORY BOWEL DISEASE, IMMUNODEFICIENCY, AND ENCEPHALOPATHYTgfb1
inguinal herniaTgfbr2
Insulin ResistanceFoxo1 , Shc1
insulinomaTgfb1
intellectual disabilityCamk2a , Crebbp , Ctnnb1 , Foxo4 , Nedd4l , Ppp1ca , Smad2 , Smad4 , Smad7 , Sos1 , Tgfb3 , Tgfbr1 , Yap1
interstitial lung diseaseTgfb1
interstitial nephritisDcn
Intestinal NeoplasmsCtnnb1 , Runx1
Intestinal Reperfusion InjuryPpp1r15a
Intimal HyperplasiaFoxo3
intrahepatic cholangiocarcinomaRunx1 , Smad4
invasive ductal carcinomaCav1 , Pml , Runx3 , Smad4
invasive lobular carcinomaCtnnb1
islet cell tumorDaxx
isolated microphthalmia 3Nedd4l
Joubert syndrome 1Rps6kb1 , Tgfb1
Joubert syndrome 3Sos1
juvenile myelomonocytic leukemiaRunx1
juvenile polyposis syndromeSmad4
juvenile polyposis-hereditary hemorrhagic telangiectasia syndromeSmad4
juvenile rheumatoid arthritisSmad3
keratoconusFoxo1
kidney diseaseTgfb1 , Tgfbr1 , Tgfbr2
Kidney Reperfusion InjuryDaxx , Tgfb1
Knee OsteoarthritisCtnnb1
Kohlschutter-Tonz syndromeCrebbp
large cell carcinomaStrap
Larsen syndromeCamk2a
latent autoimmune diabetes in adultsTab2
Left Ventricular HypertrophyCcn2 , Ctnnb1 , Foxo3 , Rhoa , Rps6kb1 , Shc1
left ventricular noncompactionTgfb3 , Ywhae
leiomyomaCav1 , Smad3 , Tgfbr1
leukemiaDaxx
LeukoencephalopathiesRhoa
limited sclerodermaCav1
liver cirrhosisA2m , Arrb2 , Axin1 , Bambi , Ccn2 , Ctnnb1 , Foxo3 , Shc1 , Smad3 , Smad7 , Tgfb1 , Tgfb2 , Tgfbr1
Liver MetastasisDaxx , Smad4
Liver NeoplasmsAtf3 , Ctnnb1 , Dact2
Liver Reperfusion InjuryMap3k7
localized sclerodermaTgfb1
Loeys-Dietz syndromeSmad3 , Tgfb2 , Tgfb3 , Tgfbr1 , Tgfbr2
Loeys-Dietz syndrome 1Tgfbr1 , Tgfbr2
Loeys-Dietz syndrome 2Tgfbr2
Loeys-Dietz syndrome 3Smad3
Loeys-Dietz syndrome 4Tgfb2 , Tgfb3
Loeys-Dietz syndrome 5Tgfb3
Loeys-Dietz syndrome 6Smad2
Loeys-Dietz Syndrome, Type 1bTgfbr2
long QT syndromeDynlrb1 , Itch , Tgfb3 , Tgfbrap1
long QT syndrome 6Runx1
low tension glaucomaCav1
lung adenocarcinomaCrebbp , Ctnnb1 , Foxo3 , Rhoa , Runx1 , Smad4 , Sos1 , Tgfb2
lung cancerAxin1 , Ctnnb1 , Pml , Smad3 , Smad4
lung carcinomaCtnnb1 , Strap
lung diseaseA2m , Ccn2 , Tgfb1
Lung NeoplasmsA2m , Cav1 , Ccn2 , Ctnnb1 , Runx3 , Tgfb1 , Tgfbr2
lung non-small cell carcinomaAtf3 , Axin1 , Bambi , Foxo3 , Pdpk1 , Runx1 , Runx2 , Runx3 , Smad3 , Tab2
lung non-squamous non-small cell carcinomaDaxx
Lung Reperfusion InjuryCrebbp
lung small cell carcinomaCrebbp
lung squamous cell carcinomaCrebbp , Ctnnb1
Lymphatic MetastasisBambi , Cav1 , Ctnnb1 , Pdpk1 , Rhoa , Runx1 , Smad4
lymphoblastic lymphomaFoxo1 , Foxo3 , Foxo4
lymphoid leukemiaRunx1
Lymphomatoid PapulosisTgfb1
lymphoproliferative syndromeXiap
lymphoproliferative syndrome 2Xiap
Lynch syndromeSmad2 , Smad3 , Smad4 , Sos1 , Tgfbr1 , Tgfbr2
MacrocephalyFoxo4
male infertilitySos1
malignant mesotheliomaCtnnb1 , Tgfb2
malignant pleural mesotheliomaXiap
Mandibular NeoplasmsCtnnb1
mantle cell lymphomaCtnnb1
maple syrup urine diseaseTgfb1
Marfan syndromeTgfbr1 , Tgfbr2
Marfan Syndrome Type 2Tgfbr2
Marfanoid Hypermobility SyndromeTgfbr1 , Tgfbr2
Marfanoid Mental Retardation Syndrome, AutosomalCrebbp
Marinesco-Sjogren syndromeEif2a
Martsolf SyndromeTgfb2
Meckel Syndrome 10Tgfb1
medulloblastomaCrebbp , Ctnnb1 , Foxo3
megacolonA2m
melanomaCav1 , Crebbp , Ctnnb1
membranoproliferative glomerulonephritisCcn2 , Tgfbr2
membranous glomerulonephritisA2m , Rhoa
Memory DisordersCreb1
Menke-Hennekam SyndromeCrebbp
Menke-Hennekam Syndrome 1Crebbp
Mental Retardation, Autosomal Recessive 53Sptbn1
MesotheliomaXiap
metabolic dysfunction-associated steatohepatitisSmad4
metabolic dysfunction-associated steatotic liver diseaseFoxo1 , Tgfb1
Metabolic SyndromeTgfb1
metaphyseal dysplasia-maxillary hypoplasia-brachydactyly syndromeRunx2
MetaplasiaCtnnb1
MHC class I deficiencyDaxx
MHC class II deficiencyShc1
Microcephaly, Epilepsy, and Diabetes SyndromeSmad2
Micronuclei, Chromosome-DefectivePpp2r2a
Microphthalmia, Cataracts, and Iris AbnormalitiesSmad4
Microsatellite InstabilityTgfbr2
middle cerebral artery infarctionAtf3 , Camk2a , Creb1 , Runx1 , Tgfb1
migraineTab2 , Tgfbr2
Miller-Dieker lissencephaly syndromeYwhae
mismatch repair cancer syndromeTgfbr2
mitochondrial metabolism diseaseCamk2a
Mitral Regurgitation, Conductive Deafness, and Fusion of Cervical Vertebrae and of Carpal and Tarsal BonesMap3k7
morphine dependenceCreb1
morphine withdrawal syndromeCreb1
Mucinous CystadenomaDaxx
multicentric Castleman diseaseRunx1
Multiple AbnormalitiesCtnnb1 , Sptbn1
multiple acyl-CoA dehydrogenase deficiencyTgfbr2
multiple myelomaCrebbp , Pml , Runx1 , Tgfb1 , Yap1
multiple sclerosisA2m , Cav1 , Rhoa
Multisystem Autoimmune Disease with Facial DysmorphismItch
Muscle HypotoniaSos1
muscular atrophyCtnnb1 , Rps6kb1
muscular diseaseSmad4 , Tgfb1
Musculoskeletal AbnormalitiesTgfb2
myelodysplastic syndromeCrebbp , Runx1
myelofibrosisTgfb1
myeloid neoplasmRunx1
myocardial infarctionCcn2 , Creb1 , Dcn , Map3k7 , Rps6kb1 , Smad2 , Smad3 , Smad4 , Tgfb1 , Tgfb2 , Tgfbr1 , Tgfbr2
Myocardial IschemiaCtnnb1 , Dcn , Eif2a , Ppp2ca
Myocardial Reperfusion InjuryArrb2 , Atf3 , Crebbp , Rhoa , Smad3 , Smad4 , Tgfb1 , Xiap
myoepitheliomaTgfbr1
Nasal PolypsTgfb1
NecrosisCcn2
NeointimaFoxo4
Neoplasm InvasivenessCtnnb1 , Rhoa , Tgfb1 , Yap1
Neoplasm MetastasisCav1 , Creb1 , Ctnnb1 , Daxx , Dcn , Pml , Rhoa , Smad4 , Tgfb1 , Tgfbr1 , Tgfbr2 , Yap1 , Ywhae
Neoplasms, Second PrimaryPml
Neoplastic Cell TransformationAtf3 , Ctnnb1 , Ocln , Tgfb1
nephritisSmad7
nephroblastomaCtnnb1 , Smad4
Nephrogenic Fibrosing DermopathyCav1
nephrolithiasisTgfb1
nephronophthisisTgfbr1
nephrosclerosisTgfb1
nephrotic syndromeA2m , Runx2 , Tgfb1
nephrotoxicityCamk2a , Tgfb1
Nerve DegenerationCtnnb1
nervous system diseaseAtf3
Nervous System MalformationsCrebbp , Ctnnb1
NeuralgiaTgfb1
neuroblastomaYap1
Neurocutaneous SyndromesRhoa
Neurodevelopmental Disorder and Language Delay with or Without Structural Brain AbnormalitiesPpp2ca
NEURODEVELOPMENTAL DISORDER WITH MICROCEPHALY, ARTHROGRYPOSIS, AND STRUCTURAL BRAIN ANOMALIESCrebbp
Neurodevelopmental DisordersCamk2a , Creb1 , Crebbp , Ctnnb1 , Ocln , Ppp2ca , Sos1 , Sptbn1 , Zfyve16
neuroendocrine tumorDaxx
neuronal ceroid lipofuscinosisSmad3
neuronal ceroid lipofuscinosis 1Rps6kb1
nicotine dependenceArrb2 , Creb1
No-Reflow PhenomenonCtnnb1
non-alcoholic fatty liverCreb1
non-Hodgkin lymphomaRhoa
nonsyndromic deafnessTgfb3
Noonan Like SyndromeSos1
Noonan syndromeSos1
Noonan syndrome 1Sos1
Noonan syndrome 3Sos1
Noonan syndrome 4Sos1
Nuchal Bleb, FamilialSos1
obesityBambi , Cav1 , Dcn , Foxo3 , Rhoa , Rps6kb1 , Tgfb1
obsessive-compulsive disorderCreb1
obstructive lung diseaseA2m
occupational asthmaTgfb1
Occupational DiseasesTgfb1
Odontogenic CystsSmad4
open-angle glaucomaCav1
opiate dependenceArrb2
opioid abuseCreb1
OpsismodysplasiaMap3k7
Optic Nerve InjuriesRhoa
oral squamous cell carcinomaAxin1 , Daxx
oral submucous fibrosisTgfb1
orofacial cleft 1Runx2
osteoarthritisCav1 , Runx2 , Smad3 , Tgfb1 , Tgfbr1
Osteoarthritis, HipRunx2 , Smad3
osteochondrodysplasiaTgfb1 , Tgfb2 , Tgfbr1
osteogenesis imperfectaSmad4
osteoporosisTgfb1
osteosarcomaRunx2
osteosclerosisCtnnb1
otitis mediaA2m
Otitis Media with EffusionA2m
ovarian cancerCcn2 , Ctnnb1 , Runx3 , Smad2 , Smad4
ovarian carcinomaCav1 , Ccn2 , Rhoa , Smad2
Ovarian NeoplasmsAtf3 , Cav1 , Ctnnb1 , Smad7 , Xiap , Yap1
ovary epithelial cancerDaxx , Runx3 , Tab2
Paget's disease of bonePml
pain agnosiaArrb2
pancreatic adenocarcinomaCtnnb1 , Smad4 , Smad7
pancreatic adenosquamous carcinomaTgfb2
pancreatic cancerCtnnb1 , Daxx , Runx3 , Smad2 , Smad3 , Smad4 , Smad7 , Smurf1 , Tgfb1 , Tgfbr2
pancreatic carcinomaSmad4
pancreatic ductal adenocarcinomaSmad2 , Tgfb1 , Tgfb2 , Tgfb3 , Tgfbr1
pancreatic ductal carcinomaMap3k7 , Smad4 , Tgfb1 , Tgfbr2
pancreatic endocrine carcinomaDaxx
pancytopeniaRunx1
PAPA syndromePml
papillary renal cell carcinomaXiap
papillary thyroid carcinomaCtnnb1 , Runx3
papillomaTgfb1
paraplegiaFoxo4
Paraquat LungSkil , Smad7 , Tgfb1
Parasitic Liver DiseasesSmad4
parathyroid carcinomaAtf3 , Shc1 , Tgfb2
Parathyroid NeoplasmsCtnnb1
Parkinson's diseaseA2m , Ccn2 , Creb1 , Ppp2ca
Parkinson's disease 20Runx1
ParkinsonismFkbp1a
peripheral nervous system diseaseAtf3
peripheral T-cell lymphomaRhoa
Peritoneal FibrosisTgfb1
Peritoneal NeoplasmsCtnnb1
peritonitisA2m
periventricular nodular heterotopiaNedd4l
Periventricular Nodular Heterotopia 5Nedd4l
Periventricular Nodular Heterotopia 7Nedd4l
pervasive developmental disorderSptbn1
Peyronie's diseaseTgfb1
Phyllodes TumorCtnnb1
Pick's diseaseCreb1
Pierson syndromeRhoa
pilomatrixomaCtnnb1
platelet storage pool deficiencyRunx1
pleomorphic xanthoastrocytomaCav1 , Smurf1
pleural diseaseTgfb1
pneumoniaTgfb1
polycystic liver diseaseCtnnb1
Polycystic Liver Disease 1Ctnnb1
polycystic ovary syndromeRunx3 , Tab1
portal hypertensionArrb2
Posterior Leukoencephalopathy SyndromeTgfb1
Postmenopausal OsteoporosisTgfb1
Postoperative Cognitive DysfunctionCreb1
pre-eclampsiaCrebbp , Pml
pre-malignant neoplasmSmad3 , Smad4
Premature AgingFoxo1
Prenatal Exposure Delayed EffectsCcn2 , Creb1
primary biliary cholangitisCcn2 , Rps6kb1 , Tgfb1
primary cutaneous T-cell non-Hodgkin lymphomaRhoa
Primary Graft DysfunctionCcn2
primary open angle glaucomaCav1
primary pulmonary hypertensionCav1 , Creb1
primary pulmonary hypertension 1Smad4
primary pulmonary hypertension 3Cav1
Progressive Diaphyseal Dysplasia 1Tgfb1
progressive osseous heteroplasiaCtnnb1
prostate adenocarcinomaCtnnb1 , Grb2 , Pdpk1 , Smad4
prostate cancerAtf3 , Cav1 , Ctnnb1 , Daxx , Foxo1 , Foxo3 , Grb2 , Map3k7 , Pdpk1 , Ppp2ca , Skil , Smad3 , Sos1 , Tgfb1 , Tgfbr2 , Tgfbr3 , Xiap
prostate carcinoma in situSmad4
Prostatic NeoplasmsAtf3 , Cav1 , Crebbp , Ctnnb1 , Foxo1 , Map3k7 , Pml , Ppp2r2a , Runx1 , Smad4 , Tgfb1 , Tgfbr2 , Wwp1 , Xiap
prostatitisBambi , Smad4
proteasome-associated autoinflammatory syndrome 1Daxx
proteinuriaRhoa , Tgfb1
pseudo-TORCH syndrome 1Ocln
psoriasisCav1 , Runx3 , Tgfb1
psoriatic arthritisRunx2
ptosisSos1
Pulmonary Arterial HypertensionCav1 , Creb1 , Map3k7 , Smad4 , Tgfbr1
pulmonary embolismCcn2
pulmonary emphysemaTgfb1
pulmonary fibrosisCav1 , Ccn2 , Skil , Smad4 , Smad7 , Tab2 , Tgfb1 , Tgfbr2
pulmonary hypertensionCav1 , Ccn2 , Foxo1 , Rhoa , Smad4 , Smad7 , Tgfb1 , Tgfbr1 , Tgfbr2
pulmonary sarcoidosisTgfb1
pulmonary tuberculosisAtf3
pulmonary valve stenosisSos1
Radiation InjuriesTgfbr2
Radiation PneumonitisTgfb1
Radioulnar Synostosis with Amegakaryocytic Thrombocytopenia 2Cav1
RASopathySos1
RecurrenceCtnnb1 , Yap1
Recurrent Infections, with Encephalopathy, Hepatic Dysfunction, and Cardiovascular MalformationsPpp1ca
renal cell carcinomaCav1 , Ctnnb1 , Smad2 , Smad4 , Tgfb1 , Xiap
Renal Cell Carcinoma 1Ctnnb1
renal fibrosisArrb2
Reperfusion InjuryCav1 , Eif2a , Tgfbr2
Respiratory System AbnormalitiesTgfb2 , Tgfb3
restrictive cardiomyopathyCcn2
retinal cone dystrophy 3ARunx2
retinal diseaseOcln
rheumatoid arthritisA2m , Ccn2 , Foxo3 , Runx1 , Runx2 , Tab2
rhinitisTgfb1
Right Ventricular HypertrophyTgfb1
Rotavirus InfectionsPml
Rubinstein-Taybi syndromeCrebbp , Tab1
sarcoidosisTgfb1
SarcopeniaCav1 , Foxo4
schizophreniaCreb1 , Pml
sciatic neuropathyCav1 , Creb1 , Runx1
scimitar syndromeSmad2
scoliosisCrebbp
seminomaSmad4
SepsisA2m , Tgfb1 , Xiap
Serous CystadenomaDaxx
severe acute respiratory syndromeTgfb1
severe congenital neutropenia 3Shc1
severe congenital neutropenia 5Shc1
Sezary's diseaseCrebbp
short-rib thoracic dysplasia 9 with or without polydactylyAxin1 , Crebbp , Pdpk1
sickle cell anemiaTgfb1
silicosisCav1
Sjogren's syndromeTgfb1
skin cancerPml
skin diseaseSkil
skin melanomaCrebbp , Ctnnb1
Skin NeoplasmsCtnnb1 , Tgfb1 , Tgfbr1
spermatogenic failure 57Sos1
Spina Bifida CysticaRunx1
Spinal Cord InjuriesBambi , Cav1 , Foxo3 , Ppp1r15a , Rhoa , Smurf1 , Tgfb1 , Tgfb2
Spinal Cord Reperfusion InjuryCreb1
SplenomegalyOcln
SpondylarthritisRunx2
Spontaneous AbortionsTgfb1 , Tgfbr1
Spontaneous Neoplasm RegressionTgfb1
squamous cell carcinomaCav1 , Crebbp , Smurf2 , Tgfb1
squamous cell neoplasmStrap
status epilepticusFoxo3
steatotic liver diseaseCreb1 , Shc1
Stevens-Johnson syndromeCav1 , Ctnnb1 , Pml
Stiff-Person syndromeCtnnb1
stomach cancerBambi , Ctnnb1 , Daxx , Runx1 , Runx3 , Smad4
Stomach NeoplasmsCav1 , Ctnnb1 , Rhoa , Runx3 , Smad4 , Sptbn1
Stomatognathic System AbnormalitiesRunx2
StrokeCtnnb1 , Map3k7 , Nedd4l , Ppp1r15a , Sos1 , Tgfb1
Subarachnoid HemorrhageMap3k7 , Yap1
substance dependenceCreb1
Sudden Unexpected Nocturnal Death SyndromeSos1
suppurative otitis mediaA2m
syndactylyNedd4l
syndromic X-linked intellectual disability Lubs typeFoxo4 , Xiap
systemic lupus erythematosusTab2
systemic sclerodermaCav1 , Ccn2 , Tgfbr1
T-cell acute lymphoblastic leukemiaRunx1
T-cell non-Hodgkin lymphomaRhoa , Runx1
temporal lobe epilepsyFoxo3
tendinitisCcn2
teratomaCrebbp , Ctnnb1
tetralogy of FallotFoxh1
thalassemiaPpp1r15a
Therapy-related Acute Myeloid LeukemiaRunx1
thoracic aortic aneurysmSmad2 , Smad3 , Smad4 , Tgfb2 , Tgfb3 , Tgfbr1 , Tgfbr2 , Tgfbr3
thrombocytopeniaRunx1 , Tgfb1
Thumb DeformityCrebbp
Thyroid NeoplasmsCtnnb1
Tobacco Use DisorderArrb2
Tooth AbnormalitiesRunx2
tooth diseaseRhoa
toxic shock syndromeA2m
tracheal stenosisTgfb1
transient cerebral ischemiaCamk2a , Cav1 , Creb1 , Daxx , Map3k7 , Ppp1r15a
transient myeloproliferative syndromeRunx1
transitional cell carcinomaCav1 , Crebbp , Ctnnb1 , Daxx , Smad4
Transplant RejectionArrb2
traumatic brain injuryOcln , Tgfb1
Triple Negative Breast NeoplasmsYap1
trypanosomiasisA2m
Tubulointerstitial FibrosisSmad3 , Tgfb1
type 1 diabetes mellitusFoxo1 , Tgfb1
type 1 diabetes mellitus 5Tab2
type 2 diabetes mellitusArrb2 , Atf3 , Ccn2 , Dcn , Foxo1 , Ppp2ca , Smad4 , Tgfb1 , Tgfbr2
uremiaRunx2 , Tgfb1 , Tgfbr1
ureteral obstructionCcn2 , Skil , Smad3 , Tgfb1 , Tgfb2
urethral obstructionTgfb1
urinary bladder cancerAxin1 , Cav1 , Crebbp , Ctnnb1 , Rhoa , Runx3 , Smad2 , Smad4 , Tgfbr1
Urinary Bladder NeoplasmCtnnb1
Urogenital AbnormalitiesTgfb2
Urologic NeoplasmsRhoa
urticariaTgfb1
Usher syndromeTgfb2
uterine cancerCtnnb1 , Sos1
Uterine Cervical NeoplasmsCrebbp , Ctnnb1 , Smad4 , Xiap
Uterine NeoplasmsCtnnb1 , Smad3
uveal coloboma-cleft lip and palate-intellectual disabilityYap1
uveitisTgfb1
Vascular CalcificationCtnnb1
vascular dementiaCreb1 , Smad4
vasculogenic impotenceTgfbr2
Ventricular Dysfunction, LeftCtnnb1
Ventricular Dysfunction, RightCreb1
Ventricular Outflow ObstructionBambi
Ventricular Premature ComplexesTgfb3
Ventricular RemodelingCtnnb1 , Smad2 , Smad3 , Tgfb1
Ventricular TachycardiaSos1
Vici syndromeSmad2
visceral heterotaxyFoxh1
vitiligoTgfb1
Wallerian DegenerationTgfb1 , Tgfb2
Weight GainCav1 , Sptbn1
Wilson diseaseA2m , Camk2a
withdrawal disorderCreb1 , Rhoa , Runx2 , Smurf1
Wolff-Parkinson-White syndromeMap3k7 , Tgfbr2 , Wwp1
Wounds and InjuriesDcn , Tgfb1 , Tgfb2 , Tgfb3
X Chromosome, Trisomy Xq25Xiap
X-linked lymphoproliferative syndrome 1Xiap
X-linked lymphoproliferative syndrome 2Xiap
Zika feverPpp1r15a
Pathway Annotations Associated with Genes in the transforming growth factor-beta Smad dependent signaling pathway
Pathway TermsGene Symbols
activin signaling pathwayFkbp1a , Smad2 , Smad3
acute myeloid leukemia pathwayGrb2 , Pml , Rps6kb1 , Runx1 , Sos1
adenosine monophosphate-activated protein kinase (AMPK) signaling pathwayPpp1ca , Ppp2ca
adenosine signaling pathwayCreb1 , Pard6a , Pdpk1
aldosterone signaling pathwayCrebbp , Daxx , Nedd4l , Pdpk1
altered transforming growth factor-beta Smad dependent signaling pathwaySmad2 , Smad3 , Smad4 , Smad7 , Tgfb1 , Tgfbr1 , Tgfbr2
altered Wnt signaling, canonical pathwayAxin1 , Ctnnb1
Alzheimer's disease pathwayA2m
amyotrophic lateral sclerosis pathwayDaxx
androgen signaling pathwayCrebbp
angiotensin II signaling pathwayPdpk1
angiotensin II signaling pathway via AT1 receptorArrb2
antigen processing and presentation pathwayCreb1
apoptotic cell death pathwayXiap
arrhythmogenic right ventricular cardiomyopathy pathwayCtnnb1
ataxia telangiectasia-mutated (ATM) signaling pathwayPpp2ca
B cell receptor signaling pathwayGrb2 , Sos1
basal cell carcinoma pathwayAxin1 , Ctnnb1
Bone morphogenetic proteins signaling pathwayBambi , Map3k7 , Ppp1ca , Ppp1r15a , Smad4 , Smad7 , Smurf1 , Smurf2 , Tab1 , Tab2 , Xiap , Zfyve16
brain-derived neurotrophic factor signaling pathwayGrb2 , Shc1
c-Jun N-terminal kinases MAPK signaling pathwayMap3k7
calcium signaling pathway via the calcium-sensing receptorArrb2 , Rhoa
calcium/calcium-mediated signaling pathwayCamk2a
calcium/calmodulin dependent kinase 2 signaling pathwayCamk2a , Ppp2ca
cell cycle pathway, mitoticCrebbp , Smad2 , Smad3 , Smad4 , Tgfb1 , Tgfb2 , Tgfb3 , Ywhae
ceramide signaling pathwayEif2a , Smad2 , Smad3 , Smad4 , Tgfb1 , Tgfb2 , Tgfb3 , Tgfbr1 , Tgfbr2
Chagas disease pathwayPpp2ca , Ppp2cb , Ppp2r2a , Smad2 , Smad3 , Tgfb1 , Tgfb2 , Tgfb3 , Tgfbr1 , Tgfbr2
chemokine mediated signaling pathwayArrb2 , Foxo3 , Grb2 , Rhoa , Shc1 , Sos1
chronic myeloid leukemia pathwayGrb2 , Runx1 , Shc1 , Smad3 , Smad4 , Sos1 , Tgfb1 , Tgfb2 , Tgfb3 , Tgfbr1 , Tgfbr2
coagulation cascade pathwayA2m
colorectal cancer pathwayAxin1 , Ctnnb1 , Rhoa , Smad2 , Smad3 , Smad4 , Smad7 , Tgfb1 , Tgfb2 , Tgfb3 , Tgfbr1 , Tgfbr2
complement system pathwayA2m
corticotropin-releasing hormone signaling pathwayArrb2
cortisol signaling pathwayCrebbp
cytokine mediated signaling pathwayTgfb1 , Tgfb2 , Tgfb3 , Tgfbr1 , Tgfbr2
dilated cardiomyopathy pathwayTgfb1 , Tgfb2 , Tgfb3
dopamine signaling pathwayPpp1ca , Ppp2ca , Ppp2cb
dopamine signaling pathway via D1 family of receptorsArrb2
dopamine signaling pathway via D2 family of receptorsArrb2
E-cadherin signaling pathwayCtnnb1 , Rhoa
eicosanoid signaling pathwayArrb2 , Rhoa
eicosanoid signaling pathway via peroxisome proliferator-activated receptor gammaPdpk1
endocytosis pathwayArrb2 , Cav1 , Itch , Nedd4l , Pard6a , Pml , Rhoa , Smad2 , Smad3 , Smad7 , Smurf2 , Tgfb1 , Tgfb2 , Tgfb3 , Tgfbr1 , Tgfbr2 , Wwp1 , Zfyve16 , Zfyve9
endometrial cancer pathwayAxin1 , Ctnnb1 , Foxo3 , Grb2 , Pdpk1 , Sos1
endoplasmic reticulum stress - the unfolded protein response pathwayEif2a
Endoplasmic Reticulum-associated degradation pathwayPpp1r15a
endothelin signaling pathwayRhoa
Entamoebiasis pathwayTgfb1 , Tgfb2 , Tgfb3
ephrin - ephrin receptor bidirectional signaling axisGrb2 , Map3k7 , Rhoa
epidermal growth factor/neuregulin signaling pathwayCamk2a , Grb2 , Rps6kb1 , Shc1 , Sos1
epinephrine signaling pathway via adrenergic receptor betaArrb2
erythropoietin signaling pathwayGrb2 , Shc1 , Sos1
estrogen signaling pathwayCrebbp
FasL mediated signaling pathwayPdpk1
Fc epsilon receptor mediated signaling pathwayGrb2 , Sos1
Fc gamma receptor mediated signaling pathwayRps6kb1
fibroblast growth factor signaling pathwayCamk2a , Grb2 , Pdpk1 , Runx2 , Shc1 , Sos1
follicle-stimulating hormone signaling pathwayCreb1 , Ppp1ca
forkhead class A signaling pathwayCreb1 , Crebbp
glioma pathwayCamk2a , Grb2 , Shc1 , Sos1
glycogen biosynthetic pathwayPpp1ca
glycogen degradation pathwayPpp1ca
glypican signaling pathwaySmad2 , Tgfb1 , Tgfb2 , Tgfb3 , Tgfbr1 , Tgfbr2
gonadotropin-releasing hormone signaling pathwayCamk2a , Grb2 , Sos1
granulocyte-macrophage colony-stimulating factor signaling pathwayGrb2 , Shc1 , Sos1
Hedgehog signaling pathwayArrb2 , Crebbp , Tgfb2
hepatitis C pathwayGrb2 , Ocln , Ppp2ca , Ppp2cb , Ppp2r2a , Sos1
histamine signaling pathway, immunologicalCreb1 , Ppp1ca
histone modification pathwayCrebbp , Daxx
Huntington's disease pathwayCreb1 , Crebbp
hypertrophic cardiomyopathy pathwayTgfb1 , Tgfb2 , Tgfb3
hypoxia inducible factor pathwayCreb1 , Crebbp , Smad3 , Smad4
immune response pathwayA2m
inflammatory response pathwayA2m
influenza A pathwayCrebbp , Pml
insulin responsive facilitative sugar transporter mediated glucose transport pathwayYwhae
insulin signaling pathwayCav1 , Foxo1 , Foxo3 , Grb2 , Pard6a , Pdpk1 , Ppp1ca , Rps6kb1 , Shc1 , Sos1
insulin-like growth factor signaling pathwayGrb2 , Pdpk1 , Rps6kb1 , Shc1 , Sos1 , Ywhae
interleukin-1 signaling pathwayMap3k7 , Tab1 , Tab2
interleukin-2 signaling pathwayGrb2 , Rhoa , Shc1 , Sos1
interleukin-27 signaling pathwayTgfb1
interleukin-3 signaling pathwayGrb2 , Shc1
interleukin-4 signaling pathwayGrb2 , Rps6kb1 , Shc1
interleukin-5 signaling pathwayGrb2
interleukin-6 signaling pathwayA2m , Foxo1 , Grb2 , Sos1
intrinsic apoptotic pathwayXiap
Jak-Stat signaling pathwayCrebbp , Grb2 , Sos1
kallikrein-kinin cascade pathwayA2m
kinin signaling pathwayArrb2
Leishmaniasis pathwayMap3k7 , Tgfb1 , Tgfb2 , Tgfb3
long term depressionPpp2ca , Ppp2cb
long term potentiationCamk2a , Crebbp , Ppp1ca
luteinizing hormone signaling pathwayCreb1 , Ppp1ca
malaria pathwayTgfb1 , Tgfb2 , Tgfb3
measles pathwayMap3k7
mitochondria transport pathwayDynlrb1
mitogen activated protein kinase signaling pathwayArrb2 , Daxx , Grb2 , Map3k7 , Shc1 , Sos1 , Tgfb1 , Tgfb2 , Tgfb3 , Tgfbr1 , Tgfbr2
mRNA decay pathwayPpp2ca , Ppp2cb , Ppp2r2a
mTOR signaling pathwayFkbp1a , Pdpk1 , Pml , Rhoa , Rps6kb1 , Ywhae
myocarditis pathwayCav1
N-cadherin signaling pathwayAxin1 , Ctnnb1 , Rhoa
nerve growth factor signaling pathwaySos1
neurotrophic factor signaling pathwayCamk2a , Foxo3 , Grb2 , Rhoa , Shc1 , Sos1 , Ywhae
NOD-like receptor signaling pathwayMap3k7 , Xiap
non-small cell lung carcinoma pathwayFoxo3 , Grb2 , Pdpk1 , Sos1
Notch signaling pathwayCrebbp , Itch
nuclear factor kappa B signaling pathwayArrb2 , Map3k7 , Tab1 , Tab2
nuclear factor, erythroid 2 like 2 signaling pathwayCrebbp
p38 MAPK signaling pathwayMap3k7 , Tab1 , Tab2
p53 signaling pathwayCrebbp , Daxx , Ppp2ca
pancreatic cancer pathwaySmad2 , Smad3 , Smad4 , Tgfb1 , Tgfb2 , Tgfb3 , Tgfbr1 , Tgfbr2
parathyroid hormone signaling pathwayArrb2
phosphatidylinositol 3-kinase class I signaling pathwayFoxo3 , Pdpk1 , Rhoa
phosphatidylinositol 3-kinase-Akt signaling pathwayFoxo1 , Foxo3 , Foxo4 , Pdpk1 , Ppp2ca , Ppp2cb , Ppp2r2a , Ywhae
platelet-derived growth factor signaling pathwayCav1 , Grb2 , Ppp2ca , Rhoa , Shc1 , Sos1 , Ywhae
prostate cancer pathwayCreb1 , Crebbp , Ctnnb1 , Foxo1 , Grb2 , Pdpk1 , Sos1
protein kinase C (PKC) signaling pathwayPard6a , Pdpk1
Ras family mediated signaling pathwaySos1
renal cell carcinoma pathwayCrebbp , Grb2 , Sos1 , Tgfb1 , Tgfb2 , Tgfb3
Retinoic acid-inducible gene (RIG) I-like receptor signaling pathwayMap3k7
reverse cholesterol transport pathwayCav1
rheumatoid arthritis pathwayTgfb1 , Tgfb2 , Tgfb3
Rho/Rac/Cdc42 mediated signaling pathwayRhoa
RNA polymerase I transcription pathwayCrebbp
RNA transport pathwayStrap
scatter factor/hepatocyte growth factor signaling pathwayGrb2 , Shc1
serotonin signaling pathway via receptors engaging G alphas protein familyCreb1 , Ppp1ca
small cell lung carcinoma pathwayXiap
sphingosine 1-phosphate signaling pathwayRhoa
syndecan signaling pathwayRhoa , Tgfb1
T cell receptor signaling pathwayGrb2 , Map3k7 , Rhoa , Sos1
the extracellular signal-regulated Raf/Mek/Erk signaling pathwayShc1
thyroid cancer pathwayCtnnb1
Toll-like receptor signaling pathwayMap3k7 , Tab1 , Tab2
toxoplasmosis pathwayMap3k7 , Tgfb1 , Tgfb2 , Tgfb3 , Xiap
transforming growth factor-beta signaling pathwayCav1
transforming growth factor-beta Smad dependent signaling pathwayA2m , Arrb2 , Atf3 , Axin1 , Bambi , Camk2a , Cav1 , Ccn2 , Creb1 , Crebbp , Ctnnb1 , Dact2 , Daxx , Dcn , Dynlrb1 , Eif2a , Fkbp1a , Foxh1 , Foxo1 , Foxo3 , Foxo4 , Grb2 , Itch , Map3k7 , Nedd4l , Ocln , Pard6a , Pdpk1 , Pml , Ppp1ca , Ppp1r15a , Ppp2ca , Ppp2cb , Ppp2r2a , Rhoa , Rnf111 , Rps6kb1 , Runx1 , Runx2 , Runx3 , Shc1 , Skil , Smad2 , Smad3 , Smad4 , Smad7 , Smurf1 , Smurf2 , Sos1 , Sptbn1 , Strap , Tab1 , Tab2 , Tgfb1 , Tgfb2 , Tgfb3 , Tgfbr1 , Tgfbr2 , Tgfbr3 , Tgfbrap1 , Wwp1 , Xiap , Yap1 , Ywhae , Zfyve16 , Zfyve9
transforming growth factor-beta superfamily mediated signaling pathwayCrebbp , Dcn , Ppp2ca , Ppp2cb , Rhoa , Rps6kb1 , Smad2 , Smad3 , Smad4 , Smad7 , Smurf2 , Tgfb1 , Tgfb2 , Tgfb3 , Tgfbr1 , Tgfbr2 , Zfyve16 , Zfyve9
tuberculosis pathwayCamk2a , Creb1 , Crebbp , Rhoa , Tgfb1 , Tgfb2 , Tgfb3
tumor necrosis factor mediated signaling pathwayCav1 , Itch , Map3k7 , Tab1 , Tab2
type II interferon signaling pathwayCamk2a , Crebbp , Smad7
ubiquitin/proteasome degradation pathwayItch , Nedd4l , Pml , Smurf2 , Wwp1 , Xiap
vascular endothelial growth factor signaling pathwayCav1 , Ctnnb1 , Grb2 , Pdpk1 , Rhoa
vasopressin signaling pathway via receptor type 2Creb1
visual phototransduction pathwayArrb2
Wnt signaling pathwayAxin1 , Camk2a , Crebbp , Ctnnb1 , Map3k7 , Ppp2ca , Ppp2cb , Rhoa , Smad2 , Smad3 , Smad4
Wnt signaling, canonical pathwayAxin1 , Cav1 , Crebbp , Ctnnb1
Wnt signaling, non-canonical pathwayArrb2 , Camk2a , Map3k7 , Rhoa , Tab1 , Tab2
Wnt signaling, the planar cell polarity pathwayRhoa
Phenotype Annotations Associated with Genes in the transforming growth factor-beta Smad dependent signaling pathway

References Associated with the transforming growth factor-beta Smad dependent signaling pathway:

Ontology Path Diagram:

paths to the root
paths to the root

Import into Pathway Studio: