Kcnk6 (potassium two pore domain channel subfamily K member 6) - Rat Genome Database

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Gene: Kcnk6 (potassium two pore domain channel subfamily K member 6) Rattus norvegicus
Analyze
Symbol: Kcnk6
Name: potassium two pore domain channel subfamily K member 6
RGD ID: 621450
Description: Enables potassium channel activity. Predicted to be involved in potassium ion transmembrane transport. Predicted to act upstream of or within negative regulation of systemic arterial blood pressure and regulation of resting membrane potential. Predicted to be active in plasma membrane. Biomarker of brain infarction. Orthologous to human KCNK6 (potassium two pore domain channel subfamily K member 6); INTERACTS WITH 1,3-dinitrobenzene; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC100909725; potassium channel subfamily K member 6; potassium channel subfamily K member 6 (TWIK-2); potassium channel subfamily K member 6-like; potassium channel, subfamily K, member 6; potassium channel, subfamily K, member 6 (TWIK-2); potassium channel, two pore domain subfamily K, member 6; potassium inwardly-rectifying channel, subfamily K, member 6; Twik-2; Twik2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8193,652,888 - 93,661,419 (-)NCBIGRCr8
mRatBN7.2184,525,613 - 84,533,948 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl184,525,590 - 84,534,677 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx189,937,040 - 89,945,285 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0198,396,659 - 98,404,888 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0191,692,885 - 91,701,131 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0188,168,438 - 88,176,610 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl188,169,378 - 88,176,610 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0 Ensembl187,166,109 - 87,174,821 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0189,343,864 - 89,352,036 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4184,359,738 - 84,367,910 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1184,404,339 - 84,446,021 (-)NCBI
Celera178,912,886 - 78,921,054 (-)NCBICelera
Cytogenetic Map1q21NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Identification of new therapeutic targets by genome-wide analysis of gene expression in the ipsilateral cortex of aged rats after stroke. Buga AM, etal., PLoS One. 2012;7(12):e50985. doi: 10.1371/journal.pone.0050985. Epub 2012 Dec 12.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
5. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
6. TWIK-2, an inactivating 2P domain K+ channel. Patel AJ, etal., J Biol Chem 2000 Sep 15;275(37):28722-30.
7. GOA pipeline RGD automated data pipeline
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:8889548   PMID:18838117   PMID:19363137   PMID:21876070   PMID:23637138  


Genomics

Comparative Map Data
Kcnk6
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8193,652,888 - 93,661,419 (-)NCBIGRCr8
mRatBN7.2184,525,613 - 84,533,948 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl184,525,590 - 84,534,677 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx189,937,040 - 89,945,285 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0198,396,659 - 98,404,888 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0191,692,885 - 91,701,131 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0188,168,438 - 88,176,610 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl188,169,378 - 88,176,610 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0 Ensembl187,166,109 - 87,174,821 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0189,343,864 - 89,352,036 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4184,359,738 - 84,367,910 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1184,404,339 - 84,446,021 (-)NCBI
Celera178,912,886 - 78,921,054 (-)NCBICelera
Cytogenetic Map1q21NCBI
KCNK6
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381938,319,845 - 38,332,076 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1938,319,845 - 38,332,076 (+)EnsemblGRCh38hg38GRCh38
GRCh371938,810,485 - 38,822,716 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361943,502,322 - 43,511,494 (+)NCBINCBI36Build 36hg18NCBI36
Build 341943,502,323 - 43,511,487NCBI
Celera1935,612,720 - 35,621,891 (+)NCBICelera
Cytogenetic Map19q13.2NCBI
HuRef1935,258,112 - 35,267,183 (+)NCBIHuRef
CHM1_11938,810,843 - 38,820,013 (+)NCBICHM1_1
T2T-CHM13v2.01941,122,020 - 41,134,251 (+)NCBIT2T-CHM13v2.0
Kcnk6
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39728,921,353 - 28,931,947 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl728,921,351 - 28,931,940 (-)EnsemblGRCm39 Ensembl
GRCm38729,221,928 - 29,232,522 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl729,221,926 - 29,232,515 (-)EnsemblGRCm38mm10GRCm38
MGSCv37730,006,947 - 30,017,541 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36728,930,688 - 28,941,253 (-)NCBIMGSCv36mm8
Celera723,793,186 - 23,803,782 (-)NCBICelera
Cytogenetic Map7B1NCBI
cM Map716.94NCBI
Kcnk6
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554681,108,025 - 1,117,366 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554681,108,025 - 1,117,366 (-)NCBIChiLan1.0ChiLan1.0
KCNK6
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22044,604,902 - 44,623,635 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11946,475,224 - 46,495,898 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01935,409,752 - 35,422,490 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11943,984,592 - 43,995,374 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1943,985,074 - 43,995,374 (+)Ensemblpanpan1.1panPan2
KCNK6
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11114,665,958 - 114,677,845 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1114,666,476 - 114,677,639 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1114,070,430 - 114,081,304 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01115,268,446 - 115,279,326 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1115,267,617 - 115,279,326 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11114,841,288 - 114,852,160 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01114,458,924 - 114,469,776 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01115,497,600 - 115,508,474 (-)NCBIUU_Cfam_GSD_1.0
Kcnk6
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934912,927,338 - 12,937,848 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049368011,092,692 - 1,103,210 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049368011,092,694 - 1,101,940 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
KCNK6
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl647,238,685 - 47,249,136 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1647,237,665 - 47,249,178 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2642,739,715 - 42,747,510 (+)NCBISscrofa10.2Sscrofa10.2susScr3
KCNK6
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1632,959,275 - 32,977,601 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl632,962,535 - 32,973,196 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607310,904,586 - 10,921,256 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Kcnk6
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046251476,580 - 14,674 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046251473,759 - 16,164 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Kcnk6
48 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:204
Count of miRNA genes:150
Interacting mature miRNAs:163
Transcripts:ENSRNOT00000027974, ENSRNOT00000032394
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2313059Bss55Bone structure and strength QTL 553.20.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)143284731118944897Rat
631688Hcas2Hepatocarcinoma susceptibility QTL 230.0001liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)15925874115540829Rat
1578649Bmd8Bone mineral density QTL 84.9femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)14939317294393172Rat
1582234Gluco18Glucose level QTL 183.40.0003blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)178479925123479925Rat
1358359Sradr1Stress Responsive Adrenal Weight QTL 14.74adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)130882023123479925Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)149393289199050459Rat
1578780Cm52Cardiac mass QTL 523.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)181591954219808434Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)149393172159356837Rat
1554320Bmd1Bone mineral density QTL 112.20.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)150910886060548Rat
2302059Pia36Pristane induced arthritis QTL 363.80.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)14333300288333002Rat
1300121Hrtrt1Heart rate QTL 13.7heart pumping trait (VT:2000009)heart rate (CMO:0000002)165789093115540829Rat
7421628Bp361Blood pressure QTL 3610.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)166023617118608521Rat
631495Bp96Blood pressure QTL 964.52arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)122340647102268831Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132356093162846471Rat
631512Scl6Serum cholesterol level QTL 69.6blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)17219768090508767Rat
2298545Neuinf8Neuroinflammation QTL 84.6nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)157336763151090257Rat
2313072Bss53Bone structure and strength QTL 534.30.0001tibia length (VT:0004357)tibia length (CMO:0000450)143284731118944897Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132737458199368955Rat
2313078Bss54Bone structure and strength QTL 543.50.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)143284731118944897Rat
1549903Bp267Blood pressure QTL 267arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)177876254106047988Rat
2313083Bmd74Bone mineral density QTL 7440.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)182174743118944897Rat
2313402Anxrr24Anxiety related response QTL 24aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)148963584144267916Rat
4889494Scort2Serum corticosterone level QTL 24.2blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)180592172125592172Rat
61342Bp27Blood pressure QTL 273.40.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)15673266898773277Rat
1300172Bp172Blood pressure QTL 1723.56arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)13273727390665040Rat
61344Bp29Blood pressure QTL 297.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)178350581123350581Rat
1358192Ept13Estrogen-induced pituitary tumorigenesis QTL 133.4pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)177494165122494165Rat
2313094Bss58Bone structure and strength QTL 583.70.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)143284731118944897Rat
6903308Scl36Serum cholesterol QTL 3620.0125blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)15386304190532583Rat
2300164Bmd44Bone mineral density QTL 445.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)156949932101949932Rat
2313099Bss56Bone structure and strength QTL 562.40.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)143284731118944897Rat
2313098Bmd70Bone mineral density QTL 703.60.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)143284731118944897Rat
738022Anxrr13Anxiety related response QTL 134.60.00039locomotor behavior trait (VT:0001392)number of 20 x 20 cm floor squares crossed into, out of or within a discrete space in an experimental apparatus (CMO:0001514)183547917128547917Rat
10054135Gmadr2Adrenal mass QTL 21.970.0129adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)177857876122857876Rat
7411712Strs4Sensitivity to stroke QTL 48.7cerebrum integrity trait (VT:0010549)percentage of study population developing cerebrovascular lesions during a period of time (CMO:0000932)178430536123430536Rat
2313051Bss57Bone structure and strength QTL 573.70.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)143284731118944897Rat
61433Cia2Collagen induced arthritis QTL 25joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)17843075491209302Rat

Markers in Region
AI012809  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_5.01153,151,053 - 153,151,545NCBIRnor5.0
Rnor_5.0188,347,237 - 88,347,729NCBIRnor5.0
Rnor_5.0189,344,028 - 89,344,520NCBIRnor5.0
RGSC_v3.4184,359,903 - 84,360,394UniSTSRGSC3.4
RGSC_v3.4X159,307,255 - 159,307,746UniSTSRGSC3.4
Celera178,913,051 - 78,913,542UniSTS
Celera1136,762,666 - 136,763,157UniSTS
RH 3.4 Map1885.0UniSTS
Cytogenetic Map1q21UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
12 12 55 63 55 31 12 31 12 104 48 31 13 37 24

Sequence


Ensembl Acc Id: ENSRNOT00000027974   ⟹   ENSRNOP00000027973
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl184,525,590 - 84,534,677 (-)Ensembl
Rnor_6.0 Ensembl187,166,109 - 87,174,821 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000032394   ⟹   ENSRNOP00000061815
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl188,169,378 - 88,176,610 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000089578   ⟹   ENSRNOP00000068630
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl187,167,395 - 87,174,530 (-)Ensembl
RefSeq Acc Id: NM_053806   ⟹   NP_446258
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8193,653,247 - 93,661,419 (-)NCBI
mRatBN7.2184,525,775 - 84,533,948 (-)NCBI
Rnor_6.0188,168,438 - 88,176,610 (-)NCBI
Rnor_5.0189,343,864 - 89,352,036 (-)NCBI
RGSC_v3.4184,359,738 - 84,367,910 (-)RGD
Celera178,912,886 - 78,921,054 (-)RGD
Sequence:
RefSeq Acc Id: XM_039109439   ⟹   XP_038965367
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8193,652,888 - 93,661,237 (-)NCBI
mRatBN7.2184,525,613 - 84,533,762 (-)NCBI
RefSeq Acc Id: XM_039109467   ⟹   XP_038965395
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8193,652,888 - 93,661,238 (-)NCBI
mRatBN7.2184,525,613 - 84,533,768 (-)NCBI
RefSeq Acc Id: XM_039109523   ⟹   XP_038965451
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8193,652,888 - 93,661,222 (-)NCBI
mRatBN7.2184,525,613 - 84,533,760 (-)NCBI
RefSeq Acc Id: NP_446258   ⟸   NM_053806
- UniProtKB: G3V8R8 (UniProtKB/TrEMBL),   Q9ERU5 (UniProtKB/TrEMBL),   A6J9P6 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000061815   ⟸   ENSRNOT00000032394
RefSeq Acc Id: XP_038965395   ⟸   XM_039109467
- Peptide Label: isoform X1
- UniProtKB: Q9ERU4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038965367   ⟸   XM_039109439
- Peptide Label: isoform X1
- UniProtKB: Q9ERU4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038965451   ⟸   XM_039109523
- Peptide Label: isoform X1
- UniProtKB: Q9ERU4 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000068630   ⟸   ENSRNOT00000089578
Ensembl Acc Id: ENSRNOP00000027973   ⟸   ENSRNOT00000027974
Protein Domains
Potassium channel

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-G3V8R8-F1-model_v2 AlphaFold G3V8R8 1-313 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13689901
Promoter ID:EPDNEW_R426
Type:initiation region
Name:Kcnk6_1
Description:potassium two pore domain channel subfamily K member 6
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0188,176,613 - 88,176,673EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621450 AgrOrtholog
BioCyc Gene G2FUF-60187 BioCyc
Ensembl Genes ENSRNOG00000020598 Ensembl, UniProtKB/TrEMBL
  ENSRNOG00000049868 Ensembl
Ensembl Transcript ENSRNOT00000027974.6 UniProtKB/TrEMBL
Gene3D-CATH 1.10.287.70 UniProtKB/TrEMBL
InterPro 2pore_dom_K_chnl UniProtKB/TrEMBL
  2pore_dom_K_chnl_TASK UniProtKB/TrEMBL
  Ion_trans_2 UniProtKB/TrEMBL
  K_chnl_2pore_TWIK UniProtKB/TrEMBL
  K_chnl_2pore_TWIK2 UniProtKB/TrEMBL
KEGG Report rno:116491 UniProtKB/TrEMBL
NCBI Gene 116491 ENTREZGENE
PANTHER PTHR11003 UniProtKB/TrEMBL
  PTHR11003:SF28 UniProtKB/TrEMBL
Pfam Ion_trans_2 UniProtKB/TrEMBL
PhenoGen Kcnk6 PhenoGen
PIRSF K_channel_subfamily_K_type UniProtKB/TrEMBL
PRINTS 2POREKCHANEL UniProtKB/TrEMBL
  TWIK2CHANNEL UniProtKB/TrEMBL
  TWIKCHANNEL UniProtKB/TrEMBL
RatGTEx ENSRNOG00000020598 RatGTEx
  ENSRNOG00000049868 RatGTEx
Superfamily-SCOP Voltage-gated potassium channels UniProtKB/TrEMBL
UniProt A6J9P6 ENTREZGENE, UniProtKB/TrEMBL
  G3V8R8 ENTREZGENE, UniProtKB/TrEMBL
  Q9ERU4 ENTREZGENE, UniProtKB/TrEMBL
  Q9ERU5 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Kcnk6  potassium two pore domain channel subfamily K member 6  LOC100909725  potassium channel subfamily K member 6-like  Data merged from RGD:6501929 737654 PROVISIONAL
2016-02-11 Kcnk6  potassium two pore domain channel subfamily K member 6  Kcnk6  potassium channel, two pore domain subfamily K, member 6  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2015-01-26 Kcnk6  potassium channel, two pore domain subfamily K, member 6  Kcnk6  potassium channel, subfamily K, member 6  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2012-07-05 LOC100909725  potassium channel subfamily K member 6-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2010-04-20 Kcnk6  potassium channel, subfamily K, member 6  Kcnk6  potassium inwardly-rectifying channel, subfamily K, member 6  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-22 Kcnk6  potassium inwardly-rectifying channel, subfamily K, member 6  Kcnk6  potassium channel, subfamily K, member 6  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-20 Kcnk6  potassium channel, subfamily K, member 6    potassium channel, subfamily K, member 6 (TWIK-2)  Name updated 1299863 APPROVED
2002-08-07 Kcnk6  potassium channel, subfamily K, member 6 (TWIK-2)      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_domains contains 2P domains 633163
gene_other shows an extremely low conductance 633163