Klk1c10 Rat (-)-Arctigenin decreases expression ISO KLK3 (Homo sapiens) 6480464 arctigenin results in decreased expression of KLK3 mRNA and arctigenin results in decreased expression of KLK3 protein CTD PMID:25380086 Klk1c10 Rat (-)-Arctigenin multiple interactions ISO KLK3 (Homo sapiens) 6480464 Quercetin inhibits the reaction [arctigenin results in decreased expression of KLK3 mRNA] and Quercetin inhibits the reaction [arctigenin results in decreased expression of KLK3 protein] CTD PMID:25380086 Klk1c10 Rat (20S)-ginsenoside Rg3 multiple interactions ISO KLK3 (Homo sapiens) 6480464 ginsenoside Rg3 inhibits the reaction [Testosterone results in increased expression of KLK3 mRNA] and ginsenoside Rg3 inhibits the reaction [Testosterone results in increased expression of KLK3 protein] CTD PMID:22101440 Klk1c10 Rat 10H-phenothiazine multiple interactions ISO KLK3 (Homo sapiens) 6480464 phenothiazine analog affects the reaction [Dihydrotestosterone results in increased expression of KLK3 protein] CTD PMID:17606915 Klk1c10 Rat 17alpha-ethynylestradiol decreases expression EXP 6480464 Ethinyl Estradiol results in decreased expression of KLK1C10 mRNA CTD PMID:17557909 Klk1c10 Rat 17alpha-ethynylestradiol multiple interactions ISO KLK3 (Homo sapiens) 6480464 [Cyproterone Acetate co-treated with Ethinyl Estradiol] results in decreased expression of KLK3 protein CTD PMID:10687981 Klk1c10 Rat 17beta-estradiol multiple interactions ISO KLK3 (Homo sapiens) 6480464 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Estradiol results in increased expression of KLK3 mRNA] more ... CTD PMID:10687981 more ... Klk1c10 Rat 17beta-estradiol increases secretion ISO KLK3 (Homo sapiens) 6480464 Estradiol results in increased secretion of KLK3 protein CTD PMID:15950459 Klk1c10 Rat 17beta-estradiol increases expression ISO KLK3 (Homo sapiens) 6480464 Estradiol results in increased expression of KLK3 mRNA and Estradiol results in increased expression of KLK3 protein CTD PMID:12391264 more ... Klk1c10 Rat 17beta-hydroxy-17-methylestra-4,9,11-trien-3-one decreases expression ISO KLK3 (Homo sapiens) 6480464 Metribolone results in decreased expression of KLK3 mRNA CTD PMID:12711008 Klk1c10 Rat 17beta-hydroxy-17-methylestra-4,9,11-trien-3-one multiple interactions ISO KLK3 (Homo sapiens) 6480464 1 more ... CTD PMID:15336702 more ... Klk1c10 Rat 17beta-hydroxy-17-methylestra-4,9,11-trien-3-one increases expression ISO KLK3 (Homo sapiens) 6480464 Metribolone results in increased expression of KLK3 mRNA and Metribolone results in increased expression of KLK3 protein CTD PMID:16740653 more ... Klk1c10 Rat 17beta-hydroxy-17-methylestra-4,9,11-trien-3-one increases secretion ISO KLK3 (Homo sapiens) 6480464 Metribolone results in increased secretion of KLK3 protein CTD PMID:15950459 and PMID:26729308 Klk1c10 Rat 17beta-hydroxy-5alpha-androstan-3-one affects binding ISO KLK3 (Homo sapiens) 6480464 Dihydrotestosterone binds to KLK3 protein mutant form CTD PMID:15950459 Klk1c10 Rat 17beta-hydroxy-5alpha-androstan-3-one increases secretion ISO KLK3 (Homo sapiens) 6480464 Dihydrotestosterone results in increased secretion of KLK3 protein CTD PMID:20363314 more ... Klk1c10 Rat 17beta-hydroxy-5alpha-androstan-3-one increases expression ISO KLK3 (Homo sapiens) 6480464 Dihydrotestosterone results in increased expression of KLK3 mRNA and Dihydrotestosterone results in increased expression of KLK3 protein CTD PMID:11580929 more ... Klk1c10 Rat 17beta-hydroxy-5alpha-androstan-3-one decreases expression ISO KLK3 (Homo sapiens) 6480464 Dihydrotestosterone results in decreased expression of KLK3 mRNA CTD PMID:12711008 Klk1c10 Rat 17beta-hydroxy-5alpha-androstan-3-one multiple interactions ISO KLK3 (Homo sapiens) 6480464 2 more ... CTD PMID:11580929 more ... Klk1c10 Rat 2,2',4,4'-Tetrabromodiphenyl ether increases expression EXP 6480464 2 more ... CTD PMID:27291303 Klk1c10 Rat 2,2',5,5'-tetrachlorobiphenyl increases expression EXP 6480464 2 more ... CTD PMID:23829299 Klk1c10 Rat 2,2':5',2''-terthiophene decreases expression ISO KLK3 (Homo sapiens) 6480464 alpha-terthienyl results in decreased expression of KLK3 mRNA CTD PMID:35691152 Klk1c10 Rat 2,2':5',2''-terthiophene multiple interactions ISO KLK3 (Homo sapiens) 6480464 alpha-terthienyl inhibits the reaction [Dihydrotestosterone results in increased expression of KLK3 mRNA] CTD PMID:35691152 Klk1c10 Rat 2,4-Dihydroxybenzophenone decreases expression ISO KLK3 (Homo sapiens) 6480464 2 and 4-dihydroxybenzophenone analog results in decreased expression of KLK3 mRNA CTD PMID:33684284 Klk1c10 Rat 3,3'-diindolylmethane decreases expression ISO KLK3 (Homo sapiens) 6480464 3 and 3'-diindolylmethane results in decreased expression of KLK3 mRNA CTD PMID:22495798 Klk1c10 Rat 5-aza-2'-deoxycytidine increases expression ISO KLK3 (Homo sapiens) 6480464 Decitabine results in increased expression of KLK3 mRNA CTD PMID:18174752 Klk1c10 Rat 5-aza-2'-deoxycytidine multiple interactions ISO KLK3 (Homo sapiens) 6480464 [trichostatin A co-treated with Decitabine] results in increased expression of KLK3 mRNA CTD PMID:18092350 Klk1c10 Rat 5-azacytidine increases expression ISO KLK3 (Homo sapiens) 6480464 Azacitidine analog results in increased expression of KLK3 protein CTD PMID:18324645 Klk1c10 Rat 6-propyl-2-thiouracil increases expression EXP 6480464 Propylthiouracil results in increased expression of KLK1C10 mRNA CTD PMID:24780913 Klk1c10 Rat aflatoxin B1 increases methylation ISO KLK3 (Homo sapiens) 6480464 Aflatoxin B1 results in increased methylation of KLK3 gene CTD PMID:27153756 Klk1c10 Rat alpha-naphthoflavone multiple interactions ISO KLK3 (Homo sapiens) 6480464 alpha-naphthoflavone inhibits the reaction [Benzo(a)pyrene inhibits the reaction [Dihydrotestosterone results in increased expression of KLK3 mRNA]] more ... CTD PMID:12799773 Klk1c10 Rat alsterpaullone increases expression ISO KLK3 (Homo sapiens) 6480464 alsterpaullone results in increased expression of KLK3 mRNA CTD PMID:21111724 Klk1c10 Rat amosite asbestos increases methylation ISO KLK3 (Homo sapiens) 6480464 Asbestos and Amosite results in increased methylation of KLK3 gene CTD PMID:32062310 Klk1c10 Rat androst-4-ene-3,17-dione multiple interactions ISO KLK3 (Homo sapiens) 6480464 Androstenedione inhibits the reaction [[Dihydrotestosterone binds to and results in increased activity of AR protein] which results in increased expression of KLK3 protein] CTD PMID:15336702 Klk1c10 Rat anilines decreases expression ISO KLK3 (Homo sapiens) 6480464 Aniline Compounds results in decreased expression of KLK3 protein CTD PMID:25123791 Klk1c10 Rat arsane multiple interactions ISO KLK3 (Homo sapiens) 6480464 [sodium arsenate results in increased abundance of Arsenic] which results in decreased expression of KLK3 mRNA CTD PMID:32525701 Klk1c10 Rat arsenic atom multiple interactions ISO KLK3 (Homo sapiens) 6480464 [sodium arsenate results in increased abundance of Arsenic] which results in decreased expression of KLK3 mRNA CTD PMID:32525701 Klk1c10 Rat arsenite(3-) multiple interactions ISO KLK3 (Homo sapiens) 6480464 arsenite inhibits the reaction [Fulvestrant results in decreased expression of KLK3 mRNA] CTD PMID:31646340 Klk1c10 Rat arsenite(3-) increases expression ISO KLK3 (Homo sapiens) 6480464 arsenite results in increased expression of KLK3 mRNA CTD PMID:31646340 Klk1c10 Rat arsenous acid multiple interactions ISO KLK3 (Homo sapiens) 6480464 Arsenic Trioxide inhibits the reaction [Metribolone promotes the reaction [AR protein binds to KLK3 promoter]] and Arsenic Trioxide inhibits the reaction [Metribolone promotes the reaction [NCOA2 protein binds to KLK3 promoter]] CTD PMID:19131511 Klk1c10 Rat beclomethasone increases expression ISO KLK3 (Homo sapiens) 6480464 Beclomethasone results in increased expression of KLK3 mRNA CTD PMID:9815800 Klk1c10 Rat benomyl multiple interactions ISO KLK3 (Homo sapiens) 6480464 Benomyl inhibits the reaction [Dihydrotestosterone results in increased secretion of KLK3 protein] CTD PMID:25324206 Klk1c10 Rat benzo[a]pyrene multiple interactions ISO KLK3 (Homo sapiens) 6480464 alpha-naphthoflavone inhibits the reaction [Benzo(a)pyrene inhibits the reaction [Dihydrotestosterone results in increased expression of KLK3 mRNA]] more ... CTD PMID:12799773 Klk1c10 Rat benzo[a]pyrene increases expression ISO KLK3 (Homo sapiens) 6480464 Benzo(a)pyrene results in increased expression of KLK3 mRNA CTD PMID:22316170 Klk1c10 Rat Benzo[k]fluoranthene multiple interactions ISO KLK3 (Homo sapiens) 6480464 alpha-naphthoflavone inhibits the reaction [benzo(k)fluoranthene inhibits the reaction [Dihydrotestosterone results in increased expression of KLK3 mRNA]] more ... CTD PMID:12799773 Klk1c10 Rat beta-hexachlorocyclohexane increases expression ISO KLK3 (Homo sapiens) 6480464 beta-hexachlorocyclohexane results in increased expression of KLK3 mRNA CTD PMID:33207735 Klk1c10 Rat beta-hexachlorocyclohexane multiple interactions ISO KLK3 (Homo sapiens) 6480464 bicalutamide inhibits the reaction [beta-hexachlorocyclohexane results in increased expression of KLK3 mRNA] CTD PMID:33207735 Klk1c10 Rat bicalutamide multiple interactions ISO KLK3 (Homo sapiens) 6480464 [Goserelin co-treated with bicalutamide] results in decreased expression of KLK3 protein more ... CTD PMID:11059779 more ... Klk1c10 Rat bicalutamide decreases secretion ISO KLK3 (Homo sapiens) 6480464 bicalutamide results in decreased secretion of KLK3 protein CTD PMID:16753443 Klk1c10 Rat bicalutamide increases expression ISO KLK3 (Homo sapiens) 6480464 bicalutamide results in increased expression of KLK3 protein CTD PMID:17723170 Klk1c10 Rat bicalutamide decreases expression ISO KLK3 (Homo sapiens) 6480464 bicalutamide results in decreased expression of KLK3 mRNA and bicalutamide results in decreased expression of KLK3 protein CTD PMID:15638997 more ... Klk1c10 Rat bicalutamide affects binding ISO KLK3 (Homo sapiens) 6480464 [bicalutamide binds to AR protein] which binds to KLK3 promoter CTD PMID:12376534 and PMID:15308689 Klk1c10 Rat bis(2-ethylhexyl) phthalate decreases expression ISO KLK3 (Homo sapiens) 6480464 Diethylhexyl Phthalate results in decreased expression of KLK3 mRNA CTD PMID:25369342 Klk1c10 Rat bisphenol A increases methylation EXP 6480464 bisphenol A results in increased methylation of KLK1C10 gene CTD PMID:28505145 Klk1c10 Rat bisphenol A decreases secretion ISO KLK3 (Homo sapiens) 6480464 bisphenol A results in decreased secretion of KLK3 protein CTD PMID:20363314 Klk1c10 Rat bisphenol A increases expression ISO KLK3 (Homo sapiens) 6480464 bisphenol A results in increased expression of KLK3 mRNA CTD PMID:18007998 Klk1c10 Rat butyric acid decreases expression ISO KLK3 (Homo sapiens) 6480464 Butyric Acid results in decreased expression of KLK3 mRNA CTD PMID:23524101 Klk1c10 Rat butyric acid increases expression ISO KLK3 (Homo sapiens) 6480464 Butyric Acid results in increased expression of KLK3 mRNA and Butyric Acid results in increased expression of KLK3 protein CTD PMID:23524101 Klk1c10 Rat C60 fullerene decreases expression EXP 6480464 fullerene C60 results in decreased expression of KLK1C10 mRNA CTD PMID:19167457 Klk1c10 Rat cadmium atom increases expression ISO KLK3 (Homo sapiens) 6480464 Cadmium results in increased expression of KLK3 mRNA CTD PMID:23369406 and PMID:31646340 Klk1c10 Rat cadmium dichloride increases expression ISO KLK3 (Homo sapiens) 6480464 Cadmium Chloride results in increased expression of KLK3 mRNA and Cadmium Chloride results in increased expression of KLK3 protein CTD PMID:25014244 Klk1c10 Rat cadmium dichloride multiple interactions ISO KLK3 (Homo sapiens) 6480464 AR mutant form inhibits the reaction [Cadmium Chloride results in increased expression of KLK3 mRNA] more ... CTD PMID:25014244 Klk1c10 Rat calcitriol increases expression ISO KLK3 (Homo sapiens) 6480464 Calcitriol results in increased expression of KLK3 mRNA CTD PMID:21592394 Klk1c10 Rat calcitriol increases secretion ISO KLK3 (Homo sapiens) 6480464 Calcitriol results in increased secretion of KLK3 protein CTD PMID:9231780 Klk1c10 Rat calcitriol multiple interactions ISO KLK3 (Homo sapiens) 6480464 [Calcitriol co-treated with Testosterone] results in increased expression of KLK3 mRNA and Dihydrotestosterone promotes the reaction [Calcitriol results in increased secretion of KLK3 protein] CTD PMID:21592394 and PMID:9231780 Klk1c10 Rat capsaicin multiple interactions ISO KLK3 (Homo sapiens) 6480464 Capsaicin inhibits the reaction [Dihydrotestosterone results in increased expression of KLK3 mRNA] and Capsaicin inhibits the reaction [Dihydrotestosterone results in increased expression of KLK3 protein] CTD PMID:16540674 Klk1c10 Rat carbon nanotube increases methylation ISO KLK3 (Homo sapiens) 6480464 Nanotubes and Carbon results in increased methylation of KLK3 gene CTD PMID:32062310 Klk1c10 Rat carboplatin multiple interactions ISO KLK3 (Homo sapiens) 6480464 [Paclitaxel co-treated with Carboplatin] results in decreased expression of KLK3 protein CTD PMID:16442593 Klk1c10 Rat carrageenan increases expression EXP 6480464 Carrageenan results in increased expression of KLK3 protein CTD PMID:28844677 Klk1c10 Rat carrageenan multiple interactions EXP 6480464 procyanidin B2 inhibits the reaction [Carrageenan results in increased expression of KLK3 protein] CTD PMID:28844677 Klk1c10 Rat CGP 52608 multiple interactions ISO KLK3 (Homo sapiens) 6480464 CGP 52608 promotes the reaction [RORA protein binds to KLK3 gene] CTD PMID:28238834 Klk1c10 Rat chrysene multiple interactions ISO KLK3 (Homo sapiens) 6480464 alpha-naphthoflavone inhibits the reaction [chrysene inhibits the reaction [Dihydrotestosterone results in increased expression of KLK3 mRNA]] more ... CTD PMID:12799773 Klk1c10 Rat cisplatin affects response to substance ISO KLK3 (Homo sapiens) 6480464 KLK3 protein affects the susceptibility to Cisplatin CTD PMID:16217747 Klk1c10 Rat clorgyline increases expression ISO KLK3 (Homo sapiens) 6480464 Clorgyline results in increased expression of KLK3 mRNA CTD PMID:19691856 Klk1c10 Rat colforsin daropate hydrochloride multiple interactions ISO KLK3 (Homo sapiens) 6480464 AR protein promotes the reaction [Colforsin results in increased expression of KLK3 protein] CTD PMID:16751804 Klk1c10 Rat colforsin daropate hydrochloride increases expression ISO KLK3 (Homo sapiens) 6480464 Colforsin results in increased expression of KLK3 mRNA and Colforsin results in increased expression of KLK3 protein CTD PMID:16751804 Klk1c10 Rat cortisol increases expression ISO KLK3 (Homo sapiens) 6480464 Hydrocortisone results in increased expression of KLK3 protein CTD PMID:11956172 Klk1c10 Rat Cuprizon increases expression EXP 6480464 Cuprizone results in increased expression of KLK1C10 mRNA CTD PMID:26577399 and PMID:27523638 Klk1c10 Rat curcumin multiple interactions ISO KLK3 (Homo sapiens) 6480464 Curcumin inhibits the reaction [AR protein results in increased expression of KLK3 mRNA] more ... CTD PMID:18676361 more ... Klk1c10 Rat curcumin decreases expression ISO KLK3 (Homo sapiens) 6480464 Curcumin results in decreased expression of KLK3 mRNA and Curcumin results in decreased expression of KLK3 protein CTD PMID:12497104 more ... Klk1c10 Rat Cyclopamine decreases expression ISO KLK3 (Homo sapiens) 6480464 cyclopamine results in decreased expression of KLK3 CTD PMID:26710974 Klk1c10 Rat cyclosporin A increases expression EXP 6480464 Cyclosporine results in increased expression of KLK1C10 mRNA CTD PMID:21865292 Klk1c10 Rat cyproterone acetate affects binding ISO KLK3 (Homo sapiens) 6480464 [Cyproterone Acetate binds to AR protein] which binds to KLK3 enhancer and [Cyproterone Acetate binds to AR protein] which binds to KLK3 promoter CTD PMID:15308689 Klk1c10 Rat cyproterone acetate multiple interactions ISO KLK3 (Homo sapiens) 6480464 [Cyproterone Acetate binds to AR protein] promotes the reaction [CREBBP protein binds to KLK3 enhancer] more ... CTD PMID:10687981 more ... Klk1c10 Rat cyproterone acetate decreases expression ISO KLK3 (Homo sapiens) 6480464 Cyproterone Acetate results in decreased expression of KLK3 protein CTD PMID:10687981 Klk1c10 Rat daidzein decreases expression ISO KLK3 (Homo sapiens) 6480464 daidzein results in decreased expression of KLK3 mRNA CTD PMID:16865672 Klk1c10 Rat DDE affects expression ISO KLK3 (Homo sapiens) 6480464 Dichlorodiphenyl Dichloroethylene affects the expression of KLK3 mRNA CTD PMID:25682698 Klk1c10 Rat DDE multiple interactions ISO KLK3 (Homo sapiens) 6480464 [Dichlorodiphenyl Dichloroethylene results in increased activity of AR protein mutant form] promotes the reaction [AR protein mutant form binds to KLK3 enhancer] more ... CTD PMID:18819937 and PMID:25682698 Klk1c10 Rat DDT decreases expression ISO KLK3 (Homo sapiens) 6480464 DDT results in decreased expression of KLK3 mRNA CTD PMID:25682698 Klk1c10 Rat DDT multiple interactions ISO KLK3 (Homo sapiens) 6480464 DDT inhibits the reaction [Metribolone promotes the reaction [AR protein binds to KLK3 promoter]] more ... CTD PMID:25682698 Klk1c10 Rat decabromodiphenyl ether increases expression EXP 6480464 decabromobiphenyl ether results in increased expression of KLK1C10 mRNA CTD PMID:23914054 Klk1c10 Rat Decursin decreases secretion ISO KLK3 (Homo sapiens) 6480464 decursin results in decreased secretion of KLK3 protein CTD PMID:17723170 Klk1c10 Rat Decursin multiple interactions ISO KLK3 (Homo sapiens) 6480464 decursin results in decreased expression of and results in decreased secretion of KLK3 protein CTD PMID:17723170 Klk1c10 Rat Decursin decreases expression ISO KLK3 (Homo sapiens) 6480464 decursin results in decreased expression of KLK3 mRNA CTD PMID:17723170 Klk1c10 Rat dehydroepiandrosterone increases expression ISO KLK3 (Homo sapiens) 6480464 Dehydroepiandrosterone results in increased expression of KLK3 mRNA and Dehydroepiandrosterone results in increased expression of KLK3 protein CTD PMID:17503469 Klk1c10 Rat dehydroepiandrosterone multiple interactions ISO KLK3 (Homo sapiens) 6480464 bicalutamide inhibits the reaction [Dehydroepiandrosterone results in increased expression of KLK3 mRNA] more ... CTD PMID:17503469 Klk1c10 Rat dextran sulfate multiple interactions ISO KLK3 (Homo sapiens) 6480464 Dextran Sulfate affects the reaction [SEMG2 protein binds to KLK3 protein] CTD PMID:17253189 Klk1c10 Rat diarsenic trioxide multiple interactions ISO KLK3 (Homo sapiens) 6480464 Arsenic Trioxide inhibits the reaction [Metribolone promotes the reaction [AR protein binds to KLK3 promoter]] and Arsenic Trioxide inhibits the reaction [Metribolone promotes the reaction [NCOA2 protein binds to KLK3 promoter]] CTD PMID:19131511 Klk1c10 Rat dibutyl phthalate increases secretion ISO KLK3 (Homo sapiens) 6480464 Dibutyl Phthalate results in increased secretion of KLK3 protein CTD PMID:20363314 Klk1c10 Rat diethylstilbestrol decreases expression ISO KLK3 (Homo sapiens) 6480464 Diethylstilbestrol results in decreased expression of KLK3 protein CTD PMID:15846301 Klk1c10 Rat difenoconazole decreases expression ISO KLK3 (Homo sapiens) 6480464 difenoconazole results in decreased expression of KLK3 mRNA CTD PMID:12711008 Klk1c10 Rat diosmin multiple interactions EXP 6480464 Diosmin inhibits the reaction [Testosterone Propionate results in increased expression of KLK3 protein] CTD PMID:31797688 Klk1c10 Rat dipotassium bis[mu-tartrato(4-)]diantimonate(2-) trihydrate multiple interactions ISO KLK3 (Homo sapiens) 6480464 bicalutamide inhibits the reaction [Antimony Potassium Tartrate results in increased expression of KLK3 mRNA] CTD PMID:29462692 Klk1c10 Rat dipotassium bis[mu-tartrato(4-)]diantimonate(2-) trihydrate increases expression ISO KLK3 (Homo sapiens) 6480464 Antimony Potassium Tartrate results in increased expression of KLK3 mRNA and Antimony Potassium Tartrate results in increased expression of KLK3 protein CTD PMID:29462692 Klk1c10 Rat disodium selenite decreases secretion ISO KLK3 (Homo sapiens) 6480464 Sodium Selenite results in decreased secretion of KLK3 protein CTD PMID:18760546 Klk1c10 Rat disodium selenite multiple interactions ISO KLK3 (Homo sapiens) 6480464 Mn(III) 5 more ... CTD PMID:16928829 and PMID:17346688 Klk1c10 Rat disodium selenite decreases expression ISO KLK3 (Homo sapiens) 6480464 Sodium Selenite results in decreased expression of KLK3 mRNA CTD PMID:16928829 and PMID:18760546 Klk1c10 Rat dutasteride decreases expression ISO KLK3 (Homo sapiens) 6480464 Dutasteride results in decreased expression of KLK3 mRNA CTD PMID:17636412 and PMID:20564326 Klk1c10 Rat dutasteride multiple interactions ISO KLK3 (Homo sapiens) 6480464 [Goserelin co-treated with Dutasteride co-treated with bicalutamide co-treated with Ketoconazole] results in decreased expression of KLK3 protein more ... CTD PMID:24323034 Klk1c10 Rat elemental selenium decreases expression ISO KLK3 (Homo sapiens) 6480464 Selenium results in decreased expression of KLK3 mRNA and Selenium results in decreased expression of KLK3 protein CTD PMID:14729601 Klk1c10 Rat ellagic acid decreases expression ISO KLK3 (Homo sapiens) 6480464 Ellagic Acid results in decreased expression of KLK3 mRNA CTD PMID:12002526 Klk1c10 Rat enzalutamide multiple interactions ISO KLK3 (Homo sapiens) 6480464 [enzalutamide co-treated with NVP-BHG712] results in decreased expression of KLK3 mRNA more ... CTD PMID:25970160 more ... Klk1c10 Rat enzalutamide increases expression ISO KLK3 (Homo sapiens) 6480464 enzalutamide results in increased expression of KLK3 mRNA CTD PMID:23704919 Klk1c10 Rat enzalutamide decreases expression ISO KLK3 (Homo sapiens) 6480464 enzalutamide results in decreased expression of KLK3 mRNA and enzalutamide results in decreased expression of KLK3 protein CTD PMID:19359544 more ... Klk1c10 Rat equol decreases expression ISO KLK3 (Homo sapiens) 6480464 Equol results in decreased expression of KLK3 mRNA CTD PMID:16865672 Klk1c10 Rat etoposide multiple interactions ISO KLK3 (Homo sapiens) 6480464 Etoposide inhibits the reaction [Dihydrotestosterone results in increased expression of KLK3 mRNA] CTD PMID:20601956 Klk1c10 Rat Evodiamine multiple interactions ISO KLK3 (Homo sapiens) 6480464 evodiamine inhibits the reaction [Dihydrotestosterone results in increased expression of KLK3 mRNA] CTD PMID:34713388 Klk1c10 Rat fentin acetate decreases expression ISO KLK3 (Homo sapiens) 6480464 phentin acetate results in decreased expression of KLK3 mRNA CTD PMID:12711008 Klk1c10 Rat ferrostatin-1 multiple interactions ISO KLK3 (Homo sapiens) 6480464 ferrostatin-1 inhibits the reaction [darolutamide results in decreased expression of KLK3 mRNA] CTD PMID:39309439 Klk1c10 Rat finasteride decreases expression ISO KLK3 (Homo sapiens) 6480464 Finasteride results in decreased expression of KLK3 protein CTD PMID:11118046 Klk1c10 Rat fisetin multiple interactions ISO KLK3 (Homo sapiens) 6480464 fisetin inhibits the reaction [Dihydrotestosterone results in increased expression of KLK3 protein] and fisetin results in decreased expression of and results in decreased secretion of KLK3 protein CTD PMID:18922931 Klk1c10 Rat fisetin decreases expression ISO KLK3 (Homo sapiens) 6480464 fisetin results in decreased expression of KLK3 mRNA CTD PMID:18922931 Klk1c10 Rat fludrocortisone increases expression ISO KLK3 (Homo sapiens) 6480464 Fludrocortisone results in increased expression of KLK3 protein CTD PMID:11956172 Klk1c10 Rat flutamide decreases expression ISO KLK3 (Homo sapiens) 6480464 Flutamide results in decreased expression of KLK3 mRNA and Flutamide results in decreased expression of KLK3 protein CTD PMID:11118046 and PMID:25454221 Klk1c10 Rat flutamide multiple interactions ISO KLK3 (Homo sapiens) 6480464 Flutamide inhibits the reaction [Dihydrotestosterone results in increased expression of KLK3 mRNA] more ... CTD PMID:25454221 and PMID:31586605 Klk1c10 Rat flutamide decreases secretion ISO KLK3 (Homo sapiens) 6480464 Flutamide results in decreased secretion of KLK3 protein CTD PMID:21128595 Klk1c10 Rat folic acid decreases expression ISO KLK3 (Homo sapiens) 6480464 Folic Acid results in decreased expression of KLK3 mRNA CTD PMID:21867686 Klk1c10 Rat fulvestrant decreases expression ISO KLK3 (Homo sapiens) 6480464 Fulvestrant results in decreased expression of KLK3 mRNA CTD PMID:31646340 Klk1c10 Rat fulvestrant multiple interactions ISO KLK3 (Homo sapiens) 6480464 arsenite inhibits the reaction [Fulvestrant results in decreased expression of KLK3 mRNA] more ... CTD PMID:17131305 more ... Klk1c10 Rat Galiellalactone decreases expression ISO KLK3 (Homo sapiens) 6480464 galiellalactone results in decreased expression of KLK3 mRNA CTD PMID:30254184 Klk1c10 Rat gamma-tocopherol multiple interactions ISO KLK3 (Homo sapiens) 6480464 Tocopherols inhibits the reaction [Dihydrotestosterone results in increased expression of KLK3 mRNA] and Tocopherols inhibits the reaction [Dihydrotestosterone results in increased expression of KLK3 protein] CTD PMID:12032296 Klk1c10 Rat gamma-tocopherol decreases expression ISO KLK3 (Homo sapiens) 6480464 [Tocopherols results in decreased expression of AR protein] which results in decreased expression of KLK3 protein more ... CTD PMID:12032296 and PMID:16302272 Klk1c10 Rat ganoderol B decreases expression ISO KLK3 (Homo sapiens) 6480464 ganoderol B results in decreased expression of KLK3 mRNA CTD PMID:17499997 Klk1c10 Rat genistein increases expression ISO KLK3 (Homo sapiens) 6480464 Genistein results in increased expression of KLK3 mRNA CTD PMID:12391264 Klk1c10 Rat genistein decreases expression ISO KLK3 (Homo sapiens) 6480464 Genistein results in decreased expression of KLK3 mRNA CTD PMID:15378649 more ... Klk1c10 Rat glufosinate increases secretion ISO KLK3 (Homo sapiens) 6480464 phosphinothricin results in increased secretion of KLK3 protein CTD PMID:20363314 Klk1c10 Rat Goserelin decreases secretion ISO KLK3 (Homo sapiens) 6480464 Goserelin results in decreased secretion of KLK3 protein CTD PMID:16753443 Klk1c10 Rat Goserelin increases secretion ISO KLK3 (Homo sapiens) 6480464 Goserelin results in increased secretion of KLK3 protein CTD PMID:16753443 Klk1c10 Rat Goserelin multiple interactions ISO KLK3 (Homo sapiens) 6480464 [Goserelin co-treated with bicalutamide] results in decreased expression of KLK3 protein more ... CTD PMID:24323034 Klk1c10 Rat graphite affects expression EXP 6480464 Graphite affects the expression of KLK1C10 mRNA CTD PMID:29933104 Klk1c10 Rat hydroxyflutamide decreases expression ISO KLK3 (Homo sapiens) 6480464 hydroxyflutamide results in decreased expression of KLK3 mRNA CTD PMID:29556062 Klk1c10 Rat hydroxyflutamide multiple interactions ISO KLK3 (Homo sapiens) 6480464 hydroxyflutamide inhibits the reaction [1 more ... CTD PMID:25454221 more ... Klk1c10 Rat hydroxyflutamide increases secretion ISO KLK3 (Homo sapiens) 6480464 hydroxyflutamide results in increased secretion of KLK3 protein CTD PMID:35595151 Klk1c10 Rat hydroxyflutamide affects secretion ISO KLK3 (Homo sapiens) 6480464 hydroxyflutamide affects the secretion of KLK3 protein CTD PMID:20363314 Klk1c10 Rat hydroxyflutamide affects expression ISO KLK3 (Homo sapiens) 6480464 hydroxyflutamide affects the expression of KLK3 mRNA CTD PMID:25454221 Klk1c10 Rat indirubin-3'-monoxime increases expression ISO KLK3 (Homo sapiens) 6480464 indirubin-3'-monoxime analog results in increased expression of KLK3 mRNA and indirubin-3'-monoxime results in increased expression of KLK3 mRNA CTD PMID:21111724 Klk1c10 Rat Isobavachin decreases expression ISO KLK3 (Homo sapiens) 6480464 isobavachin results in decreased expression of KLK3 mRNA and isobavachin results in decreased expression of KLK3 protein CTD PMID:37019376 Klk1c10 Rat isoflavones decreases expression ISO KLK3 (Homo sapiens) 6480464 Isoflavones results in decreased expression of KLK3 mRNA and Isoflavones results in decreased expression of KLK3 protein CTD PMID:17374662 Klk1c10 Rat kenpaullone increases expression ISO KLK3 (Homo sapiens) 6480464 kenpaullone results in increased expression of KLK3 mRNA CTD PMID:21111724 Klk1c10 Rat ketoconazole multiple interactions ISO KLK3 (Homo sapiens) 6480464 [Goserelin co-treated with Dutasteride co-treated with bicalutamide co-treated with Ketoconazole] results in decreased expression of KLK3 protein CTD PMID:24323034 Klk1c10 Rat linuron increases secretion ISO KLK3 (Homo sapiens) 6480464 Linuron results in increased secretion of KLK3 protein CTD PMID:20363314 Klk1c10 Rat linuron decreases expression ISO KLK3 (Homo sapiens) 6480464 Linuron results in decreased expression of KLK3 mRNA CTD PMID:33932781 Klk1c10 Rat LY294002 multiple interactions ISO KLK3 (Homo sapiens) 6480464 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [EGF protein results in decreased expression of and results in decreased secretion of KLK3 protein] CTD PMID:16472761 Klk1c10 Rat M1 multiple interactions ISO KLK3 (Homo sapiens) 6480464 2-(((3 more ... CTD PMID:35595151 Klk1c10 Rat methylseleninic acid affects expression ISO KLK3 (Homo sapiens) 6480464 methylselenic acid affects the expression of KLK3 mRNA CTD PMID:14617803 Klk1c10 Rat methylseleninic acid decreases secretion ISO KLK3 (Homo sapiens) 6480464 methylselenic acid results in decreased secretion of KLK3 protein CTD PMID:14617803 Klk1c10 Rat methylseleninic acid multiple interactions ISO KLK3 (Homo sapiens) 6480464 AR protein inhibits the reaction [methylselenic acid results in decreased expression of KLK3 mRNA] more ... CTD PMID:15141018 more ... Klk1c10 Rat methylseleninic acid decreases expression ISO KLK3 (Homo sapiens) 6480464 methylselenic acid results in decreased expression of KLK3 mRNA and methylselenic acid results in decreased expression of KLK3 protein CTD PMID:15141018 more ... Klk1c10 Rat methyltestosterone increases secretion ISO KLK3 (Homo sapiens) 6480464 Methyltestosterone results in increased secretion of KLK3 protein CTD PMID:20363314 Klk1c10 Rat mibolerone increases secretion ISO KLK3 (Homo sapiens) 6480464 mibolerone results in increased secretion of KLK3 protein CTD PMID:25846647 Klk1c10 Rat mibolerone multiple interactions ISO KLK3 (Homo sapiens) 6480464 methylselenic acid inhibits the reaction [mibolerone results in increased expression of KLK3 mRNA] more ... CTD PMID:10606230 more ... Klk1c10 Rat mibolerone increases expression ISO KLK3 (Homo sapiens) 6480464 mibolerone results in increased expression of KLK3 mRNA and mibolerone results in increased expression of KLK3 protein CTD PMID:10606230 and PMID:15141018 Klk1c10 Rat mifepristone multiple interactions ISO KLK3 (Homo sapiens) 6480464 [Mifepristone binds to AR protein] promotes the reaction [CREBBP protein binds to KLK3 enhancer] more ... CTD PMID:15308689 Klk1c10 Rat mifepristone affects binding ISO KLK3 (Homo sapiens) 6480464 [Mifepristone binds to AR protein] which binds to KLK3 enhancer and [Mifepristone binds to AR protein] which binds to KLK3 promoter CTD PMID:15308689 Klk1c10 Rat mono(2-ethylhexyl) phthalate multiple interactions ISO KLK3 (Homo sapiens) 6480464 [mono-(2-ethylhexyl)phthalate co-treated with Androgens deficiency] results in increased expression of KLK3 CTD PMID:26710974 Klk1c10 Rat N-acetyl-L-cysteine multiple interactions ISO KLK3 (Homo sapiens) 6480464 Acetylcysteine inhibits the reaction [SOD2 protein affects the expression of KLK3 mRNA] CTD PMID:18829485 Klk1c10 Rat nevirapine increases expression ISO KLK3 (Homo sapiens) 6480464 Nevirapine results in increased expression of KLK3 mRNA and Nevirapine results in increased expression of KLK3 protein CTD PMID:19152342 Klk1c10 Rat niclosamide decreases expression ISO KLK3 (Homo sapiens) 6480464 Niclosamide results in decreased expression of KLK3 mRNA and Niclosamide results in decreased expression of KLK3 protein CTD PMID:25970160 and PMID:28500234 Klk1c10 Rat niclosamide multiple interactions ISO KLK3 (Homo sapiens) 6480464 [Niclosamide co-treated with bicalutamide] results in decreased expression of KLK3 mRNA more ... CTD PMID:24740322 more ... Klk1c10 Rat nirogacestat multiple interactions ISO KLK3 (Homo sapiens) 6480464 [nirogacestat results in increased susceptibility to enzalutamide] which results in decreased expression of KLK3 protein CTD PMID:30940724 Klk1c10 Rat NMS-873 multiple interactions ISO KLK3 (Homo sapiens) 6480464 NMS-873 inhibits the reaction [IL6 protein results in increased expression of KLK3 protein] CTD PMID:29693262 Klk1c10 Rat nocodazole multiple interactions ISO KLK3 (Homo sapiens) 6480464 Nocodazole inhibits the reaction [Dihydrotestosterone results in increased expression of KLK3 mRNA] CTD PMID:20807808 Klk1c10 Rat norgestrel increases expression ISO KLK3 (Homo sapiens) 6480464 Norgestrel results in increased expression of KLK3 protein CTD PMID:11580929 Klk1c10 Rat Obacunone decreases expression ISO KLK3 (Homo sapiens) 6480464 obacunone results in decreased expression of KLK3 protein CTD PMID:25592883 Klk1c10 Rat paclitaxel multiple interactions ISO KLK3 (Homo sapiens) 6480464 [Paclitaxel co-treated with Carboplatin] results in decreased expression of KLK3 protein and Paclitaxel inhibits the reaction [Dihydrotestosterone results in increased expression of KLK3 mRNA] CTD PMID:16442593 and PMID:20807808 Klk1c10 Rat palbociclib multiple interactions ISO KLK3 (Homo sapiens) 6480464 palbociclib promotes the reaction [Dihydrotestosterone results in increased expression of KLK3 mRNA] CTD PMID:23708653 Klk1c10 Rat PCB138 decreases expression EXP 6480464 2 more ... CTD PMID:23829299 Klk1c10 Rat pregnenolone 16alpha-carbonitrile decreases expression EXP 6480464 Pregnenolone Carbonitrile results in decreased expression of KLK1C10 mRNA CTD PMID:19162173 Klk1c10 Rat prochloraz multiple interactions ISO KLK3 (Homo sapiens) 6480464 prochloraz inhibits the reaction [Dihydrotestosterone results in increased secretion of KLK3 protein] CTD PMID:25324206 Klk1c10 Rat procyanidin B2 multiple interactions EXP 6480464 procyanidin B2 inhibits the reaction [Carrageenan results in increased expression of KLK3 protein] CTD PMID:28844677 Klk1c10 Rat procymidone decreases expression ISO KLK3 (Homo sapiens) 6480464 procymidone results in decreased expression of KLK3 mRNA CTD PMID:33932781 Klk1c10 Rat pyrrolidine dithiocarbamate multiple interactions ISO KLK3 (Homo sapiens) 6480464 pyrrolidine dithiocarbamic acid inhibits the reaction [Testosterone results in increased expression of KLK3 mRNA] CTD PMID:16139439 Klk1c10 Rat quercetin increases expression ISO KLK3 (Homo sapiens) 6480464 Quercetin results in increased expression of KLK3 mRNA CTD PMID:12391264 Klk1c10 Rat quercetin decreases expression ISO KLK3 (Homo sapiens) 6480464 Quercetin results in decreased expression of KLK3 mRNA and Quercetin results in decreased expression of KLK3 protein CTD PMID:11238180 and PMID:25380086 Klk1c10 Rat quercetin multiple interactions ISO KLK3 (Homo sapiens) 6480464 Quercetin inhibits the reaction [AR protein results in increased expression of KLK3 mRNA] more ... CTD PMID:11238180 more ... Klk1c10 Rat resveratrol multiple interactions ISO KLK3 (Homo sapiens) 6480464 [Plant Extracts co-treated with Resveratrol] results in decreased expression of KLK3 mRNA more ... CTD PMID:10606230 more ... Klk1c10 Rat resveratrol decreases expression ISO KLK3 (Homo sapiens) 6480464 Resveratrol results in decreased expression of KLK3 mRNA and Resveratrol results in decreased expression of KLK3 protein CTD PMID:12569576 more ... Klk1c10 Rat Riluzole decreases expression ISO KLK3 (Homo sapiens) 6480464 Riluzole results in decreased expression of KLK3 mRNA CTD PMID:30280407 Klk1c10 Rat Salinomycin decreases expression ISO KLK3 (Homo sapiens) 6480464 salinomycin results in decreased expression of KLK3 mRNA and salinomycin results in decreased expression of KLK3 protein CTD PMID:22215106 Klk1c10 Rat selenium atom decreases expression ISO KLK3 (Homo sapiens) 6480464 Selenium results in decreased expression of KLK3 mRNA and Selenium results in decreased expression of KLK3 protein CTD PMID:14729601 Klk1c10 Rat selenomethionine multiple interactions ISO KLK3 (Homo sapiens) 6480464 AR protein promotes the reaction [Selenomethionine results in decreased expression of KLK3 protein] CTD PMID:17205524 Klk1c10 Rat selenomethionine decreases expression ISO KLK3 (Homo sapiens) 6480464 Selenomethionine results in decreased expression of KLK3 protein CTD PMID:17205524 Klk1c10 Rat sirolimus increases expression ISO KLK3 (Homo sapiens) 6480464 Sirolimus results in increased expression of KLK3 protein CTD PMID:18776922 Klk1c10 Rat sirolimus multiple interactions ISO KLK3 (Homo sapiens) 6480464 bicalutamide inhibits the reaction [Sirolimus results in increased expression of KLK3 protein] CTD PMID:18776922 Klk1c10 Rat sirolimus decreases expression EXP 6480464 Sirolimus results in decreased expression of KLK1C10 mRNA CTD PMID:21865292 Klk1c10 Rat sirtinol multiple interactions ISO KLK3 (Homo sapiens) 6480464 sirtinol inhibits the reaction [Estradiol results in increased expression of KLK3 mRNA] CTD PMID:22495798 Klk1c10 Rat sirtinol decreases expression ISO KLK3 (Homo sapiens) 6480464 sirtinol results in decreased expression of KLK3 mRNA and sirtinol results in decreased expression of KLK3 protein CTD PMID:22495798 Klk1c10 Rat sodium arsenate multiple interactions ISO KLK3 (Homo sapiens) 6480464 [sodium arsenate results in increased abundance of Arsenic] which results in decreased expression of KLK3 mRNA CTD PMID:32525701 Klk1c10 Rat sulforaphane decreases expression ISO KLK3 (Homo sapiens) 6480464 sulforaphane results in decreased expression of KLK3 mRNA CTD PMID:19805354 Klk1c10 Rat sulforaphane multiple interactions ISO KLK3 (Homo sapiens) 6480464 sulforaphane inhibits the reaction [AR protein binds to KLK3 enhancer] CTD PMID:19805354 Klk1c10 Rat sulindac sulfide decreases expression ISO KLK3 (Homo sapiens) 6480464 sulindac sulfide results in decreased expression of KLK3 protein CTD PMID:14581372 Klk1c10 Rat sulindac sulfide multiple interactions ISO KLK3 (Homo sapiens) 6480464 AR protein affects the reaction [sulindac sulfide results in decreased expression of KLK3 protein] CTD PMID:14581372 Klk1c10 Rat sulindac sulfone multiple interactions ISO KLK3 (Homo sapiens) 6480464 AR protein affects the reaction [sulindac sulfone results in decreased expression of KLK3 protein] CTD PMID:14581372 Klk1c10 Rat sulindac sulfone decreases expression ISO KLK3 (Homo sapiens) 6480464 sulindac sulfone results in decreased expression of KLK3 protein CTD PMID:11490238 and PMID:14581372 Klk1c10 Rat tacrolimus hydrate increases expression EXP 6480464 Tacrolimus results in increased expression of KLK1C10 mRNA CTD PMID:21865292 Klk1c10 Rat testosterone affects binding ISO KLK3 (Homo sapiens) 6480464 [Testosterone binds to AR protein] which binds to KLK3 promoter CTD PMID:12376534 Klk1c10 Rat testosterone increases expression ISO KLK3 (Homo sapiens) 6480464 Testosterone results in increased expression of KLK3 mRNA and Testosterone results in increased expression of KLK3 protein CTD PMID:15994348 more ... Klk1c10 Rat testosterone multiple interactions ISO KLK3 (Homo sapiens) 6480464 6-formylindolo(3 more ... CTD PMID:16139439 more ... Klk1c10 Rat Testosterone propionate multiple interactions EXP 6480464 Diosmin inhibits the reaction [Testosterone Propionate results in increased expression of KLK3 protein] CTD PMID:31797688 Klk1c10 Rat Testosterone propionate increases expression EXP 6480464 Testosterone Propionate results in increased expression of KLK3 protein CTD PMID:31797688 Klk1c10 Rat tetrachloromethane increases expression EXP 6480464 Carbon Tetrachloride results in increased expression of KLK3 mRNA CTD PMID:16644059 Klk1c10 Rat tetramethrin increases expression ISO KLK3 (Homo sapiens) 6480464 tetramethrin results in increased expression of KLK3 mRNA CTD PMID:12711008 Klk1c10 Rat thalidomide decreases expression ISO KLK3 (Homo sapiens) 6480464 Thalidomide results in decreased expression of KLK3 protein CTD PMID:12644816 Klk1c10 Rat thapsigargin decreases expression ISO KLK3 (Homo sapiens) 6480464 Thapsigargin results in decreased expression of KLK3 mRNA CTD PMID:30280407 Klk1c10 Rat tocopherol multiple interactions ISO KLK3 (Homo sapiens) 6480464 Tocopherols inhibits the reaction [Dihydrotestosterone results in increased expression of KLK3 mRNA] and Tocopherols inhibits the reaction [Dihydrotestosterone results in increased expression of KLK3 protein] CTD PMID:12032296 Klk1c10 Rat tocopherol decreases expression ISO KLK3 (Homo sapiens) 6480464 [Tocopherols results in decreased expression of AR protein] which results in decreased expression of KLK3 protein more ... CTD PMID:12032296 and PMID:16302272 Klk1c10 Rat trichostatin A multiple interactions ISO KLK3 (Homo sapiens) 6480464 [trichostatin A co-treated with Decitabine] results in increased expression of KLK3 mRNA and trichostatin A inhibits the reaction [Curcumin results in decreased expression of KLK3 mRNA] CTD PMID:18092350 and PMID:22258452 Klk1c10 Rat trichostatin A decreases expression ISO KLK3 (Homo sapiens) 6480464 trichostatin A results in decreased expression of KLK3 mRNA CTD PMID:19805354 Klk1c10 Rat troglitazone decreases expression ISO KLK3 (Homo sapiens) 6480464 Troglitazone results in decreased expression of KLK3 mRNA and Troglitazone results in decreased expression of KLK3 protein CTD PMID:17409431 and PMID:25669987 Klk1c10 Rat tyrphostin AG 1478 multiple interactions ISO KLK3 (Homo sapiens) 6480464 RTKI cpd inhibits the reaction [EGF protein results in decreased expression of and results in decreased secretion of KLK3 protein] CTD PMID:16472761 Klk1c10 Rat valproic acid increases methylation ISO KLK3 (Homo sapiens) 6480464 Valproic Acid results in increased methylation of KLK3 gene CTD PMID:28853863 and PMID:29201983 Klk1c10 Rat vinclozolin increases secretion ISO KLK3 (Homo sapiens) 6480464 vinclozolin results in increased secretion of KLK3 protein CTD PMID:20363314 Klk1c10 Rat vinclozolin multiple interactions ISO KLK3 (Homo sapiens) 6480464 vinclozolin inhibits the reaction [Dihydrotestosterone results in increased expression of KLK3 mRNA] more ... CTD PMID:25324206 and PMID:35595151 Klk1c10 Rat vorinostat decreases expression ISO KLK3 (Homo sapiens) 6480464 Vorinostat results in decreased expression of KLK3 mRNA and Vorinostat results in decreased expression of KLK3 protein CTD PMID:17218635 Klk1c10 Rat zinc atom multiple interactions ISO KLK3 (Homo sapiens) 6480464 Zinc affects the reaction [SEMG2 protein binds to KLK3 protein] CTD PMID:17253189 Klk1c10 Rat zinc(0) multiple interactions ISO KLK3 (Homo sapiens) 6480464 Zinc affects the reaction [SEMG2 protein binds to KLK3 protein] CTD PMID:17253189