Klk4 (kallikrein-related peptidase 4) - Rat Genome Database

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Gene: Klk4 (kallikrein-related peptidase 4) Rattus norvegicus
Analyze
Symbol: Klk4
Name: kallikrein-related peptidase 4
RGD ID: 1303228
Description: Predicted to enable serine-type peptidase activity. Predicted to be involved in amelogenesis and extracellular matrix disassembly. Predicted to act upstream of or within protein catabolic process. Predicted to be active in secretory granule. Human ortholog(s) of this gene implicated in amelogenesis imperfecta type 2A1 and prostate cancer. Orthologous to human KLK4 (kallikrein related peptidase 4); INTERACTS WITH bisphenol A; Cuprizon; genistein.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Emsp1; Enamel matrix serine proteinase 1; kallikrein 4; kallikrein 4 (prostase, enamel matrix, prostate); kallikrein b1; kallikrein-4; Klnb1
RGD Orthologs
Human
Mouse
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2194,344,195 - 94,349,425 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl194,344,195 - 94,349,424 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx199,730,033 - 99,734,406 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01108,202,660 - 108,207,031 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01101,492,287 - 101,496,632 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0199,828,944 - 99,834,642 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl199,829,351 - 99,834,216 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01100,897,206 - 100,902,435 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4194,321,663 - 94,327,488 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1194,399,773 - 94,405,599 (+)NCBI
Celera188,612,777 - 88,617,038 (+)NCBICelera
Cytogenetic Map1q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Characterization of KLK4 expression and detection of KLK4-specific antibody in prostate cancer patient sera. Day CH, etal., Oncogene. 2002 Oct 10;21(46):7114-20.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. Klk1 as one of the genes contributing to hypertension in Dahl salt-sensitive rat. Iwai N, etal., Hypertension 2005 May;45(5):947-53. Epub 2005 Apr 4.
5. Kallikrein 4 is a proliferative factor that is overexpressed in prostate cancer. Klokk TI, etal., Cancer Res. 2007 Jun 1;67(11):5221-30.
6. Specific increase of human kallikrein 4 mRNA and protein levels in breast cancer stromal cells. Mange A, etal., Biochem Biophys Res Commun. 2008 Oct 10;375(1):107-12. Epub 2008 Aug 5.
7. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
8. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
9. Expression analysis and study of KLK4 in benign and malignant breast tumours. Papachristopoulou G, etal., Thromb Haemost. 2009 Feb;101(2):381-7.
10. GOA pipeline RGD automated data pipeline
11. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
12. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
13. Comprehensive gene review and curation RGD comprehensive gene curation
14. Expression, structure, and function of enamel proteinases. Simmer JP and Hu JC, Connect Tissue Res 2002;43(2-3):441-9.
15. Kallikrein 4 is associated with paclitaxel resistance in ovarian cancer. Xi Z, etal., Gynecol Oncol. 2004 Jul;94(1):80-5.
Additional References at PubMed
PMID:15060002   PMID:15235027   PMID:19578120   PMID:21454549   PMID:22243248  


Genomics

Comparative Map Data
Klk4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2194,344,195 - 94,349,425 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl194,344,195 - 94,349,424 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx199,730,033 - 99,734,406 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01108,202,660 - 108,207,031 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01101,492,287 - 101,496,632 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0199,828,944 - 99,834,642 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl199,829,351 - 99,834,216 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01100,897,206 - 100,902,435 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4194,321,663 - 94,327,488 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1194,399,773 - 94,405,599 (+)NCBI
Celera188,612,777 - 88,617,038 (+)NCBICelera
Cytogenetic Map1q22NCBI
KLK4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381950,906,351 - 50,911,395 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1950,906,351 - 50,911,395 (-)EnsemblGRCh38hg38GRCh38
GRCh371951,409,607 - 51,414,651 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361956,101,420 - 56,105,806 (-)NCBINCBI36Build 36hg18NCBI36
Build 341956,101,419 - 56,105,806NCBI
Celera1948,460,680 - 48,464,998 (-)NCBICelera
Cytogenetic Map19q13.41NCBI
HuRef1947,742,948 - 47,747,264 (-)NCBIHuRef
CHM1_11951,411,402 - 51,415,787 (-)NCBICHM1_1
T2T-CHM13v2.01953,994,435 - 53,999,407 (-)NCBIT2T-CHM13v2.0
Klk4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39743,530,584 - 43,535,228 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl743,530,584 - 43,535,228 (+)EnsemblGRCm39 Ensembl
GRCm38743,881,160 - 43,885,804 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl743,881,160 - 43,885,804 (+)EnsemblGRCm38mm10GRCm38
MGSCv37751,136,542 - 51,141,174 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36743,749,214 - 43,753,846 (+)NCBIMGSCv36mm8
Celera739,349,912 - 39,354,544 (+)NCBICelera
Cytogenetic Map7B3NCBI
cM Map728.35NCBI
KLK4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan11958,896,711 - 58,901,306 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01947,849,158 - 47,876,522 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11956,739,394 - 56,768,169 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1956,764,073 - 56,768,169 (-)Ensemblpanpan1.1panPan2
KLK4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11105,950,948 - 105,955,464 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1105,951,691 - 106,007,581 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1105,526,312 - 105,529,783 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01106,462,891 - 106,466,451 (+)NCBIROS_Cfam_1.0
UMICH_Zoey_3.11106,134,079 - 106,137,554 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01105,775,605 - 105,779,075 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01106,571,164 - 106,574,633 (+)NCBIUU_Cfam_GSD_1.0
Klk4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934922,707,186 - 22,711,100 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936889583,302 - 586,412 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936889583,259 - 586,412 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
KLK4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl655,589,999 - 55,594,294 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1655,589,997 - 55,617,514 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2651,488,847 - 51,498,931 (-)NCBISscrofa10.2Sscrofa10.2susScr3
KLK4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1643,921,920 - 43,935,224 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl643,922,052 - 43,934,253 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607323,952,102 - 23,956,462 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Klk4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248323,828,679 - 3,831,767 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248323,828,676 - 3,832,025 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Klk4
18 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:40
Count of miRNA genes:38
Interacting mature miRNAs:38
Transcripts:ENSRNOT00000025614
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631688Hcas2Hepatocarcinoma susceptibility QTL 230.0001liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)15925874115540829Rat
631495Bp96Blood pressure QTL 964.52arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)122340647102268831Rat
1358359Sradr1Stress Responsive Adrenal Weight QTL 14.74adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)130882023123479925Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132356093162846471Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132737458199368955Rat
2313051Bss57Bone structure and strength QTL 573.70.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)143284731118944897Rat
2313059Bss55Bone structure and strength QTL 553.20.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)143284731118944897Rat
2313072Bss53Bone structure and strength QTL 534.30.0001tibia length (VT:0004357)tibia length (CMO:0000450)143284731118944897Rat
2313078Bss54Bone structure and strength QTL 543.50.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)143284731118944897Rat
2313094Bss58Bone structure and strength QTL 583.70.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)143284731118944897Rat
2313098Bmd70Bone mineral density QTL 703.60.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)143284731118944897Rat
2313099Bss56Bone structure and strength QTL 562.40.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)143284731118944897Rat
2313402Anxrr24Anxiety related response QTL 24aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)148963584144267916Rat
1578649Bmd8Bone mineral density QTL 84.9femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)14939317294393172Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)149393172159356837Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)149393289199050459Rat
61342Bp27Blood pressure QTL 273.40.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)15673266898773277Rat
2300164Bmd44Bone mineral density QTL 445.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)156949932101949932Rat
2298545Neuinf8Neuroinflammation QTL 84.6nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)157336763151090257Rat
1300121Hrtrt1Heart rate QTL 13.7heart pumping trait (VT:2000009)heart rate (CMO:0000002)165789093115540829Rat
7421628Bp361Blood pressure QTL 3610.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)166023617118608521Rat
1358192Ept13Estrogen-induced pituitary tumorigenesis QTL 133.4pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)177494165122494165Rat
10054135Gmadr2Adrenal mass QTL 21.970.0129adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)177857876122857876Rat
1549903Bp267Blood pressure QTL 267arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)177876254106047988Rat
61344Bp29Blood pressure QTL 297.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)178350581123350581Rat
7411712Strs4Sensitivity to stroke QTL 48.7cerebrum integrity trait (VT:0010549)percentage of study population developing cerebrovascular lesions during a period of time (CMO:0000932)178430536123430536Rat
1582234Gluco18Glucose level QTL 183.40.0003blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)178479925123479925Rat
4889494Scort2Serum corticosterone level QTL 24.2blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)180592172125592172Rat
1578780Cm52Cardiac mass QTL 523.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)181591954219808434Rat
2313083Bmd74Bone mineral density QTL 7440.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)182174743118944897Rat
738022Anxrr13Anxiety related response QTL 134.60.00039locomotor behavior trait (VT:0001392)number of 20 x 20 cm floor squares crossed into, out of or within a discrete space in an experimental apparatus (CMO:0001514)183547917128547917Rat
2300324Fetw1Fetal weight QTL 112.10.005fetal growth trait (VT:0004201)fetal body weight (CMO:0002080)185424647100358001Rat
724529Cm16Cardiac mass QTL 162.7heart mass (VT:0007028)calculated heart weight (CMO:0000073)187580395150700247Rat
724521Uae1Urinary albumin excretion QTL 13.80.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)190508614173018436Rat
1358902Bw47Body weight QTL 471.67body mass (VT:0001259)body weight (CMO:0000012)190508614180359386Rat
1302788Scl19Serum cholesterol QTL 194.60.001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)190532338123479925Rat
1300153Bp171Blood pressure QTL 1713.37arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)190664883143200202Rat
2293142Bp314Blood pressure QTL 314arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)192184926137184926Rat
724567Tcas6Tongue tumor susceptibility QTL 66.85tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)192948896144267916Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

endocrine system hemolymphoid system nervous system renal system reproductive system
High
Medium
Low 25 19 3
Below cutoff 1 1 14 8 5

Sequence


RefSeq Acc Id: ENSRNOT00000025614   ⟹   ENSRNOP00000025614
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl194,344,195 - 94,349,424 (+)Ensembl
Rnor_6.0 Ensembl199,829,351 - 99,834,216 (+)Ensembl
RefSeq Acc Id: NM_001004101   ⟹   NP_001004101
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2194,344,195 - 94,349,425 (+)NCBI
Rnor_6.0199,829,351 - 99,834,216 (+)NCBI
Rnor_5.01100,897,206 - 100,902,435 (+)NCBI
RGSC_v3.4194,321,663 - 94,327,488 (+)RGD
Celera188,612,777 - 88,617,038 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001004101 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein CAE51907 (Get FASTA)   NCBI Sequence Viewer  
  EDM07529 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000025614
  ENSRNOP00000025614.4
GenBank Protein SFW93261 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001004101   ⟸   NM_001004101
- Peptide Label: precursor
- UniProtKB: Q6IE12 (UniProtKB/TrEMBL),   F7F4Q8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000025614   ⟸   ENSRNOT00000025614
Protein Domains
Peptidase S1

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q6IE12-F1-model_v2 AlphaFold Q6IE12 1-256 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1303228 AgrOrtholog
BioCyc Gene G2FUF-59816 BioCyc
Ensembl Genes ENSRNOG00000018864 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000025614 ENTREZGENE
  ENSRNOT00000025614.5 UniProtKB/TrEMBL
Gene3D-CATH 2.40.10.10 UniProtKB/TrEMBL
InterPro Peptidase_S1/S6_AS UniProtKB/TrEMBL
  Peptidase_S1_PA_chymotrypsin UniProtKB/TrEMBL
  Peptidase_S1_S6 UniProtKB/TrEMBL
  Peptidase_S1A UniProtKB/TrEMBL
  Ser/Cys_Pept_Trypsin-like UniProtKB/TrEMBL
  TRYPSIN_SER UniProtKB/TrEMBL
KEGG Report rno:408210 UniProtKB/TrEMBL
NCBI Gene 408210 ENTREZGENE
PANTHER KALLIKREIN-4 UniProtKB/TrEMBL
  KALLIKREIN-RELATED UniProtKB/TrEMBL
Pfam Trypsin UniProtKB/TrEMBL
PhenoGen Klk4 PhenoGen
PRINTS CHYMOTRYPSIN UniProtKB/TrEMBL
PROSITE TRYPSIN_DOM UniProtKB/TrEMBL
  TRYPSIN_HIS UniProtKB/TrEMBL
  TRYPSIN_SER UniProtKB/TrEMBL
RatGTEx ENSRNOG00000018864 RatGTEx
SMART Tryp_SPc UniProtKB/TrEMBL
Superfamily-SCOP Pept_Ser_Cys UniProtKB/TrEMBL
UniProt A6JAK5_RAT UniProtKB/TrEMBL
  F7F4Q8 ENTREZGENE
  Q6IE12 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary F7F4Q8 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-03-04 Klk4  kallikrein-related peptidase 4   Klk4  kallikrein 4 (prostase, enamel matrix, prostate)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-11-17 Klk4  kallikrein 4 (prostase, enamel matrix, prostate)    kallikrein 4  Name updated 1299863 APPROVED
2005-07-14 Klk4  kallikrein 4      Symbol and Name status set to provisional 70820 PROVISIONAL