Kcnc3 (potassium voltage-gated channel subfamily C member 3) - Rat Genome Database

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Gene: Kcnc3 (potassium voltage-gated channel subfamily C member 3) Rattus norvegicus
Analyze
Symbol: Kcnc3
Name: potassium voltage-gated channel subfamily C member 3
RGD ID: 621358
Description: Predicted to enable delayed rectifier potassium channel activity. Predicted to be involved in potassium ion transmembrane transport and protein tetramerization. Predicted to act upstream of or within regulation of neurotransmitter secretion. Is active in glutamatergic synapse. Is integral component of postsynaptic membrane and integral component of presynaptic membrane. Human ortholog(s) of this gene implicated in spinocerebellar ataxia type 13. Orthologous to human KCNC3 (potassium voltage-gated channel subfamily C member 3); INTERACTS WITH 2,2',4,4'-Tetrabromodiphenyl ether; 2,3,7,8-tetrachlorodibenzodioxine; 2,6-dinitrotoluene.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: KShIIID; Kv3.3; potassium channel, voltage gated Shaw-related subfamily C, member 3; potassium voltage gated channel, Shaw-related subfamily, member 3; voltage-gated potassium channel subunit Kv3.3
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2195,080,960 - 95,095,165 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl195,080,960 - 95,095,160 (+)Ensembl
Rnor_6.01100,593,453 - 100,607,874 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1100,593,680 - 100,607,874 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01101,658,860 - 101,673,261 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4195,066,641 - 95,080,847 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1195,144,751 - 95,158,955 (+)NCBI
Celera189,343,211 - 89,357,385 (+)NCBICelera
RH 3.4 Map1905.4RGD
Cytogenetic Map1q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Coexpression of high-voltage-activated ion channels Kv3.4 and Cav1.2 in pioneer axons during pathfinding in the developing rat forebrain. Huang CY, etal., J Comp Neurol. 2012 Nov 1;520(16):3650-72. doi: 10.1002/cne.23119.
4. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
5. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
6. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
7. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
8. Precise localization of the voltage-gated potassium channel subunits Kv3.1b and Kv3.3 revealed in the molecular layer of the rat cerebellar cortex by a pre-embedding immunogold method. Puente N, etal., Histochem Cell Biol. 2010 Oct;134(4):403-9. doi: 10.1007/s00418-010-0742-6. Epub 2010 Sep 21.
9. GOA pipeline RGD automated data pipeline
10. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
11. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
12. Cloning of ShIII (Shaw-like) cDNAs encoding a novel high-voltage-activating, TEA-sensitive, type-A K+ channel. Vega-Saenz de Miera E, etal., Proc R Soc Lond B Biol Sci 1992 Apr 22;248(1321):9-18.
Additional References at PubMed
PMID:15240761   PMID:15610163   PMID:16403474   PMID:18682278   PMID:19953606   PMID:21479265   PMID:23734863   PMID:25152487   PMID:25756792  


Genomics

Comparative Map Data
Kcnc3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2195,080,960 - 95,095,165 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl195,080,960 - 95,095,160 (+)Ensembl
Rnor_6.01100,593,453 - 100,607,874 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1100,593,680 - 100,607,874 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01101,658,860 - 101,673,261 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4195,066,641 - 95,080,847 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1195,144,751 - 95,158,955 (+)NCBI
Celera189,343,211 - 89,357,385 (+)NCBICelera
RH 3.4 Map1905.4RGD
Cytogenetic Map1q22NCBI
KCNC3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381950,311,937 - 50,333,536 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1950,311,937 - 50,333,515 (-)EnsemblGRCh38hg38GRCh38
GRCh371950,815,194 - 50,836,793 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361955,510,577 - 55,524,446 (-)NCBINCBI36hg18NCBI36
Build 341955,510,576 - 55,524,446NCBI
Celera1947,869,096 - 47,882,964 (-)NCBI
Cytogenetic Map19q13.33NCBI
HuRef1947,156,998 - 47,170,888 (-)NCBIHuRef
CHM1_11950,820,581 - 50,834,417 (-)NCBICHM1_1
T2T-CHM13v2.01953,399,467 - 53,421,072 (-)NCBI
Kcnc3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39744,236,405 - 44,254,175 (+)NCBIGRCm39mm39
GRCm39 Ensembl744,240,088 - 44,254,178 (+)Ensembl
GRCm38744,586,939 - 44,604,751 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl744,590,664 - 44,604,754 (+)EnsemblGRCm38mm10GRCm38
MGSCv37751,846,256 - 51,860,121 (+)NCBIGRCm37mm9NCBIm37
MGSCv36744,459,162 - 44,464,606 (+)NCBImm8
Celera740,040,752 - 40,054,619 (+)NCBICelera
Cytogenetic Map7B3NCBI
cM Map728.85NCBI
Kcnc3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_004955559782,842 - 795,455 (+)NCBIChiLan1.0ChiLan1.0
KCNC3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11956,180,048 - 56,200,789 (-)NCBIpanpan1.1PanPan1.1panPan2
Mhudiblu_PPA_v01947,275,213 - 47,296,809 (-)NCBIMhudiblu_PPA_v0panPan3
KCNC3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11106,366,657 - 106,371,062 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1105,938,945 - 105,953,893 (+)NCBI
ROS_Cfam_1.01106,876,948 - 106,891,910 (+)NCBI
ROS_Cfam_1.0 Ensembl1106,876,948 - 106,889,808 (+)Ensembl
UMICH_Zoey_3.11106,549,006 - 106,563,944 (+)NCBI
UNSW_CanFamBas_1.01106,190,556 - 106,205,438 (+)NCBI
UU_Cfam_GSD_1.01107,031,217 - 107,046,175 (+)NCBI
Kcnc3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934922,310,012 - 22,327,824 (-)NCBI
SpeTri2.0NW_004936889185,349 - 203,847 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
KCNC3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl655,204,079 - 55,216,875 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1655,204,045 - 55,216,875 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2651,050,617 - 51,065,728 (-)NCBISscrofa10.2Sscrofa10.2susScr3
KCNC3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1643,374,151 - 43,391,418 (-)NCBIChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366607323,357,494 - 23,375,607 (-)NCBIVero_WHO_p1.0
Kcnc3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248324,161,068 - 4,175,721 (+)EnsemblHetGla_female_1.0hetGla2
HetGla 1.0NW_0046248324,161,510 - 4,175,744 (+)NCBIHetGla_female_1.0hetGla2

Position Markers
BF392914  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2195,086,631 - 95,086,734 (+)MAPPERmRatBN7.2
Rnor_6.01100,599,341 - 100,599,443NCBIRnor6.0
Rnor_5.01101,664,728 - 101,664,830UniSTSRnor5.0
RGSC_v3.4195,072,313 - 95,072,415UniSTSRGSC3.4
Celera189,348,883 - 89,348,985UniSTS
RH 3.4 Map1904.29UniSTS
Cytogenetic Map1q22UniSTS
BE097167  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2195,090,013 - 95,090,226 (+)MAPPERmRatBN7.2
Rnor_6.01100,602,723 - 100,602,935NCBIRnor6.0
Rnor_5.01101,668,110 - 101,668,322UniSTSRnor5.0
RGSC_v3.4195,075,695 - 95,075,907UniSTSRGSC3.4
Celera189,352,265 - 89,352,477UniSTS
RH 3.4 Map1903.4UniSTS
Cytogenetic Map1q22UniSTS
RH94540  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2195,086,653 - 95,086,743 (+)MAPPERmRatBN7.2
Rnor_6.01100,599,363 - 100,599,452NCBIRnor6.0
Rnor_5.01101,664,750 - 101,664,839UniSTSRnor5.0
RGSC_v3.4195,072,335 - 95,072,424UniSTSRGSC3.4
Celera189,348,905 - 89,348,994UniSTS
RH 3.4 Map1905.4UniSTS
Cytogenetic Map1q22UniSTS
BG373666  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2195,094,934 - 95,095,153 (+)MAPPERmRatBN7.2
Rnor_6.01100,607,644 - 100,607,862NCBIRnor6.0
Rnor_5.01101,673,031 - 101,673,249UniSTSRnor5.0
RGSC_v3.4195,080,617 - 95,080,835UniSTSRGSC3.4
Celera189,357,155 - 89,357,373UniSTS
RH 3.4 Map1903.3UniSTS
Cytogenetic Map1q22UniSTS


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631688Hcas2Hepatocarcinoma susceptibility QTL 230.0001liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)15925874115540829Rat
631495Bp96Blood pressure QTL 964.52arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)122340647102268831Rat
1358359Sradr1Stress Responsive Adrenal Weight QTL 14.74adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)130882023123479925Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132356093162846471Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132737458199368955Rat
2313051Bss57Bone structure and strength QTL 573.70.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)143284731118944897Rat
2313059Bss55Bone structure and strength QTL 553.20.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)143284731118944897Rat
2313072Bss53Bone structure and strength QTL 534.30.0001tibia length (VT:0004357)tibia length (CMO:0000450)143284731118944897Rat
2313078Bss54Bone structure and strength QTL 543.50.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)143284731118944897Rat
2313094Bss58Bone structure and strength QTL 583.70.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)143284731118944897Rat
2313098Bmd70Bone mineral density QTL 703.60.0001tibia mineral mass (VT:1000283)cortical volumetric bone mineral density (CMO:0001730)143284731118944897Rat
2313099Bss56Bone structure and strength QTL 562.40.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)143284731118944897Rat
2313402Anxrr24Anxiety related response QTL 24aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)148963584144267916Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)149393172159356837Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)149393289199050459Rat
61342Bp27Blood pressure QTL 273.40.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)15673266898773277Rat
2300164Bmd44Bone mineral density QTL 445.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)156949932101949932Rat
2298545Neuinf8Neuroinflammation QTL 84.6nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)157336763151090257Rat
1300121Hrtrt1Heart rate QTL 13.7heart pumping trait (VT:2000009)heart rate (CMO:0000002)165789093115540829Rat
7421628Bp361Blood pressure QTL 3610.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)166023617118608521Rat
1358192Ept13Estrogen-induced pituitary tumorigenesis QTL 133.4pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)177494165122494165Rat
10054135Gmadr2Adrenal mass QTL 21.970.0129adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)177857876122857876Rat
1549903Bp267Blood pressure QTL 267arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)177876254106047988Rat
61344Bp29Blood pressure QTL 297.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)178350581123350581Rat
7411712Strs4Sensitivity to stroke QTL 48.7cerebrum integrity trait (VT:0010549)percentage of study population developing cerebrovascular lesions during a period of time (CMO:0000932)178430536123430536Rat
1582234Gluco18Glucose level QTL 183.40.0003blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)178479925123479925Rat
4889494Scort2Serum corticosterone level QTL 24.2blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)180592172125592172Rat
1578780Cm52Cardiac mass QTL 523.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)181591954219808434Rat
2313083Bmd74Bone mineral density QTL 7440.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)182174743118944897Rat
738022Anxrr13Anxiety related response QTL 134.60.00039locomotor behavior trait (VT:0001392)number of 20 x 20 cm floor squares crossed into, out of or within a discrete space in an experimental apparatus (CMO:0001514)183547917128547917Rat
2300324Fetw1Fetal weight QTL 112.10.005fetal growth trait (VT:0004201)fetal body weight (CMO:0002080)185424647100358001Rat
724529Cm16Cardiac mass QTL 162.7heart mass (VT:0007028)calculated heart weight (CMO:0000073)187580395150700247Rat
724521Uae1Urinary albumin excretion QTL 13.80.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)190508614173018436Rat
1358902Bw47Body weight QTL 471.67body mass (VT:0001259)body weight (CMO:0000012)190508614180359386Rat
1302788Scl19Serum cholesterol QTL 194.60.001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)190532338123479925Rat
1300153Bp171Blood pressure QTL 1713.37arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)190664883143200202Rat
2293142Bp314Blood pressure QTL 314arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)192184926137184926Rat
724567Tcas6Tongue tumor susceptibility QTL 66.85tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)192948896144267916Rat
1331800Scl25Serum cholesterol level QTL 253.013blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)194494440117601394Rat
1331793Bp200Blood pressure QTL 2003.71601arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)194494440172949803Rat
1331751Bp199Blood pressure QTL 1993.60022arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)194494440181830018Rat
1331749Hrtrt11Heart rate QTL 112.973heart pumping trait (VT:2000009)heart rate (CMO:0000002)194494440198211706Rat
70209Niddm23Non-insulin dependent diabetes mellitus QTL 232.82blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)194494440198324465Rat
731168Bp154Blood pressure QTL 1543.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)194642722214537671Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:459
Count of miRNA genes:208
Interacting mature miRNAs:279
Transcripts:ENSRNOT00000027062, ENSRNOT00000027063
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 46 3
Low 1 5 4 4 4 28 31 20 8
Below cutoff 2 36 31 20 10 20 3 3 4 20 3

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_053997 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006228965 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006228967 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006228971 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006228972 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006228973 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008759306 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008759307 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008759308 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008759309 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017588694 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017588695 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017588696 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AY179603 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY179604 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY822673 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY822674 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473979 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JACYVU010000033 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M84210 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M84211 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000027062   ⟹   ENSRNOP00000027062
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl195,080,971 - 95,091,478 (+)Ensembl
Rnor_6.0 Ensembl1100,593,892 - 100,604,068 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000027063   ⟹   ENSRNOP00000027063
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl195,080,960 - 95,095,160 (+)Ensembl
Rnor_6.0 Ensembl1100,593,680 - 100,607,874 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000078153   ⟹   ENSRNOP00000072439
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl195,080,971 - 95,092,558 (+)Ensembl
Rnor_6.0 Ensembl1100,593,680 - 100,605,267 (+)Ensembl
RefSeq Acc Id: NM_053997   ⟹   NP_446449
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2195,080,960 - 95,095,165 (+)NCBI
Rnor_6.01100,593,669 - 100,607,874 (+)NCBI
Rnor_5.01101,658,860 - 101,673,261 (+)NCBI
RGSC_v3.4195,066,641 - 95,080,847 (+)RGD
Celera189,343,211 - 89,357,385 (+)RGD
Sequence:
Reference Sequences
RefSeq Acc Id: NP_446449   ⟸   NM_053997
- UniProtKB: Q811T3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000072439   ⟸   ENSRNOT00000078153
RefSeq Acc Id: ENSRNOP00000027063   ⟸   ENSRNOT00000027063
RefSeq Acc Id: ENSRNOP00000027062   ⟸   ENSRNOT00000027062
Protein Domains
BTB

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q01956-F1-model_v2 AlphaFold Q01956 1-889 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13690006
Promoter ID:EPDNEW_R528
Type:multiple initiation site
Name:Kcnc3_1
Description:potassium voltage-gated channel subfamily C member 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01100,593,903 - 100,593,963EPDNEW

Strain Variation

Strain Sequence Variants (MRatBN7.2)
ACI/EurMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
ACI/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN-Lx/CubMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/SsN (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BUF/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH2/CubMcwi (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH3/CubMcwi (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
DA/OlaHsd (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/DuCrl (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/NCrl (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/Stm (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FHH/EurMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE16/Stm (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE18/Stm (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
GK/FarMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB10/IpcvMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB2/IpcvMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB20/IpcvMcwi (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB31/IpcvMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB4/IpcvMcwi (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LE/Stm (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEW/Crl (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF10A/StmMcwi (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF11/Stm (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1A/Stm (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1C/Stm (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF2B/Stm (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF3/Stm (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF4/Stm (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LH/MavRrrcAek (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LL/MavRrrcAek (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LN/MavRrrcAek (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/NRrrcMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MR/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MWF/Hsd (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
PVG/Seac (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHR/OlalpcvMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHRSP/A3NCrl (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SR/JrHsd (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SS/JrHsdMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WAG/RijCrl (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/NCrl (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WN/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621358 AgrOrtholog
BioCyc Gene G2FUF-59758 BioCyc
Ensembl Genes ENSRNOG00000019959 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000027062.8 UniProtKB/TrEMBL
  ENSRNOP00000027063 ENTREZGENE
  ENSRNOP00000027063.5 UniProtKB/TrEMBL
  ENSRNOP00000072439.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000027062.8 UniProtKB/TrEMBL
  ENSRNOT00000027063 ENTREZGENE
  ENSRNOT00000027063.8 UniProtKB/TrEMBL
  ENSRNOT00000078153.2 UniProtKB/TrEMBL
Gene3D-CATH 1.20.120.350 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.30.710.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro BTB/POZ_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ion_trans_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  K_chnl_volt-dep_Kv UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  K_chnl_volt-dep_Kv3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  K_chnl_volt-dep_Kv3.3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SKP1/BTB/POZ_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  T1-type_BTB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  VG_K_chnl UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Volt_channel_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:117101 UniProtKB/TrEMBL
NCBI Gene 117101 ENTREZGENE
PANTHER PTHR11537 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam BTB_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ion_trans UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Kcnc3 PhenoGen
PRINTS KV33CHANNEL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  KVCHANNEL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SHAWCHANNEL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART BTB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF54695 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8J8XF86_RAT UniProtKB/TrEMBL
  F1LP15_RAT UniProtKB/TrEMBL
  KCNC3_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q5PXK5_RAT UniProtKB/TrEMBL
  Q5PXK6_RAT UniProtKB/TrEMBL
  Q811T2_RAT UniProtKB/TrEMBL
  Q811T3 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary F1MAD4 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-11 Kcnc3  potassium voltage-gated channel subfamily C member 3  Kcnc3  potassium channel, voltage gated Shaw-related subfamily C, member 3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2015-01-26 Kcnc3  potassium channel, voltage gated Shaw-related subfamily C, member 3  Kcnc3  potassium voltage gated channel, Shaw-related subfamily, member 3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-02-26 Kcnc3  potassium voltage gated channel, Shaw-related subfamily, member 3      Symbol and Name status set to approved 625702 APPROVED
2002-08-07 Kcnc3  potassium voltage gated channel, Shaw-related subfamily, member 3      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_domains highly sensitive to tetraethylamonium 727556
gene_process involved in neuronal excitability 727556