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Gene: Kcna1 (potassium voltage-gated channel subfamily A member 1) Rattus norvegicus
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Symbol: Kcna1
Name: potassium voltage-gated channel subfamily A member 1
Description: Exhibits delayed rectifier potassium channel activity; voltage-gated ion channel activity involved in regulation of postsynaptic membrane potential; and voltage-gated ion channel activity involved in regulation of presynaptic membrane potential. Involved in several processes, including neuronal action potential; neuronal signal transduction; and positive regulation of voltage-gated potassium channel activity. Localizes to several cellular components, including axon; glutamatergic synapse; and integral component of plasma membrane. Used to study episodic ataxia type 1 and visual epilepsy. Human ortholog(s) of this gene implicated in episodic ataxia type 1. Orthologous to human KCNA1 (potassium voltage-gated channel subfamily A member 1); INTERACTS WITH 17alpha-ethynylestradiol; 6-propyl-2-thiouracil; acrylamide.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: IA; Kcna; Kcpvd; Kv1.1; potassium (K+) channel protein voltage dependent; potassium channel, voltage gated shaker related subfamily A, member 1; potassium voltage gated channel shaker related subfamily member 1; Potassium voltage gated channel, shaker related subfamily, member 1; potassium voltage-gated channel, shaker-related subfamily, member 1; RBKI; RCK1; voltage-gated potassium channel subunit Kv1.1
Orthologs:
Allele / Splice: Kcna1Adms  
Genetic Models: F344-Kcna1Adms/Kyo
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.04159,190,781 - 159,192,526 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4159,190,804 - 159,192,526 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04226,188,851 - 226,190,596 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44163,011,777 - 163,013,522 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.14163,254,845 - 163,259,290 (-)NCBI
Celera4148,186,141 - 148,187,886 (-)NCBICelera
Cytogenetic Map4q42NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Candidate Gene Status
Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
Genetic Models
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Kcna1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 2949
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2020-05-05
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.