Gene: Kcna1 (potassium voltage-gated channel subfamily A member 1) Rattus norvegicus
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Symbol: Kcna1
Name: potassium voltage-gated channel subfamily A member 1
Description: ENCODES a protein that exhibits delayed rectifier potassium channel activity; voltage-gated ion channel activity involved in regulation of postsynaptic membrane potential; voltage-gated ion channel activity involved in regulation of presynaptic membrane potential; INVOLVED IN cell communication by electrical coupling; cellular protein localization; neuronal action potential; ASSOCIATED WITH convulsive seizures; environmentally induced seizures; ASSOCIATED WITH episodic ataxia type 1; Myokymia; visual epilepsy; FOUND IN apical plasma membrane; calyx of Held; cell surface; INTERACTS WITH (RS)-amphetamine; 17alpha-ethynylestradiol; 6-propyl-2-thiouracil
AGR Description: Exhibits delayed rectifier potassium channel activity, voltage-gated ion channel activity involved in regulation of postsynaptic membrane potential, and voltage-gated ion channel activity involved in regulation of presynaptic membrane potential; involved in several processes, including cell communication by electrical coupling, cellular protein localization, and neuronal action potential; localizes to several cellular components, including the cytoplasm, intrinsic component of plasma membrane, and neuron projection; used to study episodic ataxia type 1 and visual epilepsy; orthologous to human KCNA1 (potassium voltage-gated channel subfamily A member 1).
Merged Description: Exhibits delayed rectifier potassium channel activity, voltage-gated ion channel activity involved in regulation of postsynaptic membrane potential, and voltage-gated ion channel activity involved in regulation of presynaptic membrane potential; involved in several processes, including cell communication by electrical coupling, cellular protein localization, and neuronal action potential; localizes to several cellular components, including the cytoplasm, intrinsic component of plasma membrane, and neuron projection; used to study episodic ataxia type 1 and visual epilepsy; orthologous to human KCNA1 (potassium voltage-gated channel subfamily A member 1); INTERACTS WITH (RS)-amphetamine; 17alpha-ethynylestradiol; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: IA; Kcna; Kcpvd; Kv1.1; potassium (K+) channel protein voltage dependent; potassium channel, voltage gated shaker related subfamily A, member 1; potassium voltage gated channel shaker related subfamily member 1; Potassium voltage gated channel, shaker related subfamily, member 1; potassium voltage-gated channel, shaker-related subfamily, member 1; RBKI; RCK1; voltage-gated potassium channel subunit Kv1.1
Orthologs:
Allele / Splice: Kcna1Adms  
Genetic Models: F344-Kcna1Adms/Kyo
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.04159,190,781 - 159,192,526 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.04226,188,851 - 226,190,596 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44163,011,777 - 163,013,522 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.14163,254,845 - 163,259,290 (-)NCBI
Celera4148,186,141 - 148,187,886 (-)NCBICelera
Cytogenetic Map4q42NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


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Genomics

Candidate Gene Status
Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
Genetic Models
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome

Strain Variation

Strain Sequence Variants (Rnor 5.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Kcna1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 2949
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2019-04-12
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.