RGD Reference Report - Molecular basis of functional diversity of voltage-gated potassium channels in mammalian brain. - Rat Genome Database

Send us a Message

Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

Molecular basis of functional diversity of voltage-gated potassium channels in mammalian brain.

Authors: Stuhmer, W  Ruppersberg, JP  Schroter, KH  Sakmann, B  Stocker, M  Giese, KP  Perschke, A  Baumann, A  Pongs, O 
Citation: Stuhmer W, etal., EMBO J 1989 Nov;8(11):3235-44.
RGD ID: 69870
Pubmed: PMID:2555158   (View Abstract at PubMed)
PMCID: PMC401447   (View Article at PubMed Central)

Cloning and sequencing of cDNAs isolated from a rat cortex cDNA library reveals that a gene family encodes several highly homologous K+ channel forming (RCK) proteins. Functional characterization of the channels expressed in Xenopus laevis oocytes following microinjection of in vitro transcribed RCK-specific RNAs shows that each of the RCK proteins forms K+ channels that differ greatly in both their functional and pharmacological properties. This suggests that the molecular basis for the diversity of voltage-gated K+ channels in mammalian brain is based, at least partly, on the expression of several RCK proteins by a family of genes and their assembly to homooligomeric K+ channels with different functional properties.

Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process

Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Kcna1Ratpotassium ion transmembrane transport involved_inIMP PMID:2555158UniProt 
Kcna2Ratpotassium ion transmembrane transport involved_inIMP PMID:2555158UniProt 
Kcna3Ratpotassium ion transmembrane transport involved_inIMP PMID:2555158UniProt 
Kcna4Ratpotassium ion transmembrane transport involved_inIMP PMID:2555158UniProt 

Cellular Component

Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Kcna1Ratplasma membrane located_inIMP PMID:2555158UniProt 
Kcna2Ratplasma membrane located_inIMP PMID:2555158UniProt 
Kcna3Ratplasma membrane located_inIMP PMID:2555158UniProt 
Kcna4Ratplasma membrane located_inIMP PMID:2555158UniProt 

Molecular Function

Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Kcna1Ratvoltage-gated potassium channel activity enablesIMP PMID:2555158UniProt 
Kcna2Ratvoltage-gated potassium channel activity enablesIMP PMID:2555158UniProt 
Kcna3Ratvoltage-gated potassium channel activity enablesIMP PMID:2555158UniProt 
Kcna4Ratvoltage-gated potassium channel activity enablesIMP PMID:2555158UniProt 

Objects Annotated

Genes (Rattus norvegicus)
Kcna1  (potassium voltage-gated channel subfamily A member 1)
Kcna2  (potassium voltage-gated channel subfamily A member 2)
Kcna3  (potassium voltage-gated channel subfamily A member 3)
Kcna4  (potassium voltage-gated channel subfamily A member 4)

Additional Information