Kcna2 (potassium voltage-gated channel subfamily A member 2) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Gene: Kcna2 (potassium voltage-gated channel subfamily A member 2) Rattus norvegicus
Analyze
Symbol: Kcna2
Name: potassium voltage-gated channel subfamily A member 2
RGD ID: 2950
Description: Enables kinesin binding activity and voltage-gated monoatomic ion channel activity. Involved in several processes, including nervous system development; neuronal action potential; and potassium ion export across plasma membrane. Located in juxtaparanode region of axon; lamellipodium; and plasma membrane. Part of voltage-gated potassium channel complex. Is active in calyx of Held; glutamatergic synapse; and synaptic membrane. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 32. Orthologous to human KCNA2 (potassium voltage-gated channel subfamily A member 2); INTERACTS WITH (+)-schisandrin B; 17beta-estradiol; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: BK2; NGK1; Potassium (K+) channel protein alpha 2 voltage dependent; Potassium (K+) channel protein alpha 2, voltage dependent; potassium channel, voltage gated shaker related subfamily A, member 2; Potassium voltage gated channel shaker related subfamily member 2; Potassium voltage gated channel, shaker related subfamily, member 2; potassium voltage-gated channel, shaker-related subfamily, member 2; RAK; RBK2; RCK5; voltage-gated potassium channel subunit Kv1.2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82197,392,746 - 197,406,606 (+)NCBIGRCr8
mRatBN7.22194,704,555 - 194,718,387 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2194,704,639 - 194,718,400 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2202,344,285 - 202,348,438 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02200,231,405 - 200,235,565 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02195,048,348 - 195,052,508 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02209,838,607 - 209,852,471 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2209,838,869 - 209,852,471 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02229,303,490 - 229,316,755 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42202,560,152 - 202,564,305 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12202,522,944 - 202,527,059 (+)NCBI
Celera2187,366,228 - 187,370,362 (+)NCBICelera
Cytogenetic Map2q34NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Structure of a pore-blocking toxin in complex with a eukaryotic voltage-dependent K(+) channel. Banerjee A, etal., Elife. 2013 May 21;2:e00594. doi: 10.7554/eLife.00594.
2. The small GTP-binding protein RhoA regulates a delayed rectifier potassium channel. Cachero TG, etal., Cell. 1998 Jun 12;93(6):1077-85. doi: 10.1016/s0092-8674(00)81212-x.
3. Molecular basis of dysfunctional Kv channels in small coronary artery smooth muscle cells of streptozotocin-induced diabetic rats. Chai Q, etal., Chin J Physiol. 2007 Aug 31;50(4):171-7.
4. Two heteromeric Kv1 potassium channels differentially regulate action potential firing. Dodson PD, etal., J Neurosci. 2002 Aug 15;22(16):6953-61.
5. Presynaptic rat Kv1.2 channels suppress synaptic terminal hyperexcitability following action potential invasion. Dodson PD, etal., J Physiol. 2003 Jul 1;550(Pt 1):27-33. doi: 10.1113/jphysiol.2003.046250. Epub 2003 May 30.
6. Impaired neuropathic pain and preserved acute pain in rats overexpressing voltage-gated potassium channel subunit Kv1.2 in primary afferent neurons. Fan L, etal., Mol Pain. 2014 Jan 29;10:8. doi: 10.1186/1744-8069-10-8.
7. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
8. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
9. Tyrosine phosphorylation of Kv1.2 modulates its interaction with the actin-binding protein cortactin. Hattan D, etal., J Biol Chem. 2002 Oct 11;277(41):38596-606. Epub 2002 Jul 31.
10. Coexpression of high-voltage-activated ion channels Kv3.4 and Cav1.2 in pioneer axons during pathfinding in the developing rat forebrain. Huang CY, etal., J Comp Neurol. 2012 Nov 1;520(16):3650-72. doi: 10.1002/cne.23119.
11. Distinct roles of Kv1 and Kv3 potassium channels at the calyx of Held presynaptic terminal. Ishikawa T, etal., J Neurosci. 2003 Nov 12;23(32):10445-53.
12. Clustering of Shaker-type K+ channels by interaction with a family of membrane-associated guanylate kinases. Kim E, etal., Nature. 1995 Nov 2;378(6552):85-8.
13. Contributions of Kv1.2, Kv1.5 and Kv2.1 subunits to the native delayed rectifier K(+) current in rat mesenteric artery smooth muscle cells. Lu Y, etal., Life Sci. 2002 Aug 9;71(12):1465-73.
14. Isolation of a cDNA clone coding for a putative second potassium channel indicates the existence of a gene family. McKinnon D J Biol Chem 1989 May 15;264(14):8230-6.
15. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
16. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
17. ADAM22, a Kv1 channel-interacting protein, recruits membrane-associated guanylate kinases to juxtaparanodes of myelinated axons. Ogawa Y, etal., J Neurosci. 2010 Jan 20;30(3):1038-48. doi: 10.1523/JNEUROSCI.4661-09.2010.
18. Cloning and expression of a rat cardiac delayed rectifier potassium channel. Paulmichl M, etal., Proc Natl Acad Sci U S A 1991 Sep 1;88(17):7892-5.
19. The molecular basis for the actions of KVbeta1.2 on the opening and closing of the KV1.2 delayed rectifier channel. Peters CJ, etal., Channels (Austin). 2009 Sep-Oct;3(5):314-22. Epub 2009 Sep 16.
20. Caspr2, a new member of the neurexin superfamily, is localized at the juxtaparanodes of myelinated axons and associates with K+ channels. Poliak S, etal., Neuron. 1999 Dec;24(4):1037-47.
21. GOA pipeline RGD automated data pipeline
22. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
23. Association and colocalization of the Kvbeta1 and Kvbeta2 beta-subunits with Kv1 alpha-subunits in mammalian brain K+ channel complexes. Rhodes KJ, etal., J Neurosci. 1997 Nov 1;17(21):8246-58.
24. The role of Kif5B in axonal localization of Kv1 K(+) channels. Rivera J, etal., Eur J Neurosci. 2007 Jan;25(1):136-46.
25. Molecular basis of functional diversity of voltage-gated potassium channels in mammalian brain. Stuhmer W, etal., EMBO J 1989 Nov;8(11):3235-44.
Additional References at PubMed
PMID:8046438   PMID:8608002   PMID:11007484   PMID:11086297   PMID:11401852   PMID:12963709   PMID:12975355   PMID:15102918   PMID:16002581   PMID:16122713   PMID:16306173   PMID:16525039  
PMID:16770729   PMID:17675568   PMID:17922012   PMID:17925011   PMID:18056633   PMID:18174882   PMID:18504314   PMID:18627436   PMID:18638484   PMID:18760366   PMID:19247844   PMID:19912772  
PMID:19947938   PMID:20231479   PMID:20534430   PMID:20694152   PMID:20805574   PMID:21233214   PMID:21602278   PMID:22764231   PMID:22871113   PMID:23725331   PMID:23792947   PMID:25378149  
PMID:25588216   PMID:25661478   PMID:26047212   PMID:26835990   PMID:26950215   PMID:29056068   PMID:29263036   PMID:31140423   PMID:32315300   PMID:32621322   PMID:34632937  


Genomics

Comparative Map Data
Kcna2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82197,392,746 - 197,406,606 (+)NCBIGRCr8
mRatBN7.22194,704,555 - 194,718,387 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2194,704,639 - 194,718,400 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2202,344,285 - 202,348,438 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02200,231,405 - 200,235,565 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02195,048,348 - 195,052,508 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02209,838,607 - 209,852,471 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2209,838,869 - 209,852,471 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02229,303,490 - 229,316,755 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42202,560,152 - 202,564,305 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12202,522,944 - 202,527,059 (+)NCBI
Celera2187,366,228 - 187,370,362 (+)NCBICelera
Cytogenetic Map2q34NCBI
KCNA2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381110,593,580 - 110,631,440 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1110,519,837 - 110,631,474 (-)EnsemblGRCh38hg38GRCh38
GRCh371111,136,202 - 111,174,062 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361110,947,299 - 110,949,868 (-)NCBINCBI36Build 36hg18NCBI36
Build 341110,857,818 - 110,860,387NCBI
Celera1109,392,891 - 109,395,460 (-)NCBICelera
Cytogenetic Map1p13.3NCBI
HuRef1109,007,594 - 109,045,483 (-)NCBIHuRef
CHM1_11111,251,494 - 111,289,381 (-)NCBICHM1_1
T2T-CHM13v2.01110,608,515 - 110,647,421 (-)NCBIT2T-CHM13v2.0
Kcna2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm393106,998,203 - 107,022,321 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl3107,008,462 - 107,022,321 (+)EnsemblGRCm39 Ensembl
GRCm383107,090,883 - 107,115,005 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl3107,101,146 - 107,115,005 (+)EnsemblGRCm38mm10GRCm38
MGSCv373106,904,485 - 106,909,797 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv363107,229,623 - 107,234,935 (+)NCBIMGSCv36mm8
Celera3109,430,684 - 109,436,074 (+)NCBICelera
Cytogenetic Map3F2.3NCBI
cM Map346.61NCBI
Kcna2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543514,074,346 - 14,078,806 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495543514,074,346 - 14,080,026 (-)NCBIChiLan1.0ChiLan1.0
KCNA2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21116,433,108 - 116,484,095 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11115,580,649 - 115,631,586 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01113,187,158 - 113,256,260 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11127,087,801 - 127,118,724 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1127,090,829 - 127,092,328 (+)Ensemblpanpan1.1panPan2
KCNA2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1641,405,453 - 41,415,727 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl641,407,070 - 41,408,823 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha644,184,430 - 44,186,175 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0641,736,857 - 41,747,996 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl641,736,845 - 41,741,870 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1641,459,141 - 41,460,886 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0641,429,846 - 41,431,591 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0641,865,201 - 41,866,946 (+)NCBIUU_Cfam_GSD_1.0
Kcna2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505818,094,671 - 18,109,123 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367042,007,577 - 2,017,764 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049367042,007,577 - 2,019,520 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
KCNA2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl4109,557,973 - 109,560,998 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.14109,534,923 - 109,570,172 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
KCNA2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12022,933,524 - 22,942,074 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2022,940,154 - 22,941,650 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603835,517,971 - 35,523,444 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Kcna2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247726,305,550 - 6,309,906 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247726,298,113 - 6,311,614 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Kcna2
48 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:29
Count of miRNA genes:26
Interacting mature miRNAs:29
Transcripts:ENSRNOT00000050149
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1578648Bss11Bone structure and strength QTL 114.7femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)2114837527211674221Rat
1358356Srcrt1Stress Responsive Cort QTL13.66blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)2161699179222436696Rat
1331734Bp204Blood pressure QTL 2043.61192arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2168358098223265385Rat
1298074Bp164Blood pressure QTL 1640.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat
1354648Bp239Blood pressure QTL 2390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)266118463226797303Rat
1354649Kidm17Kidney mass QTL 172.9kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)281754530227146641Rat
1298076Bp166Blood pressure QTL 1660.0009arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2136445150202447032Rat
61458Bp10Blood pressure QTL 103.42arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2189020722215287351Rat
70162Bp63Blood pressure QTL 635.64arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)2169745596214745596Rat
1554319Bmd2Bone mineral density QTL 213.40.0001lumbar vertebra area (VT:0010570)lumbar vertebra cross-sectional area (CMO:0001689)2114837675212549332Rat
1581569Uae32Urinary albumin excretion QTL 320.0001urine protein amount (VT:0005160)urine albumin excretion rate (CMO:0000757)278665619219826953Rat
1302793Bw16Body weight QTL 1650.0001body mass (VT:0001259)body weight (CMO:0000012)2157142209202446871Rat
61467Bp14Blood pressure QTL 142.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)243154682202446871Rat
2317752Glom23Glomerulus QTL 233.6urine protein amount (VT:0005160)urine protein level (CMO:0000591)2193452645245889826Rat
61469Bp16Blood pressure QTL 165.64arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)2169745596214745596Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)absolute change in systolic blood pressure (CMO:0000607)2135552573202446871Rat
1358900Bw48Body weight QTL 484.88body mass (VT:0001259)body weight (CMO:0000012)2157142078211086598Rat
4889834Pur24Proteinuria QTL 245.80.014urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)2184114274202447032Rat
1359031Bp275Blood pressure QTL 275arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2185876309219753474Rat
1581499Esta2Estrogen-induced thymic atrophy QTL 2thymus mass (VT:0004954)thymus wet weight (CMO:0000855)2189599258226936289Rat
1331760Bp206Blood pressure QTL 2063.62454arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)256043031202447032Rat
9589044Scfw1Subcutaneous fat weight QTL 15.80.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)2182171407227171407Rat
8694435Bw166Body weight QTL 16614.080.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)2182171407227171407Rat
2301966Bp322Blood pressure QTL 3223.58arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2150540301202447032Rat
1298083Bp158Blood pressure QTL 1582.62arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2189020722215287351Rat
1298080Bp163Blood pressure QTL 1630.02arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)266118275202447032Rat
8662832Vetf7Vascular elastic tissue fragility QTL 73.5aorta elastin amount (VT:0003905)aorta wall extracellular elastin dry weight to aorta wall dry weight ratio (CMO:0002002)281689826221035911Rat
1331745Bp203Blood pressure QTL 2034.377arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2189599258218414891Rat
1298085Bp165Blood pressure QTL 1650.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat
8694194Abfw1Abdominal fat weight QTL 111.70.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)2182171407227171407Rat
61366Iddm3Insulin dependent diabetes mellitus QTL 34.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2189599258234599258Rat
1359022Ppulsi1Prepulse inhibition QTL 13.63prepulse inhibition trait (VT:0003088)acoustic startle response measurement (CMO:0001519)2136916935213594495Rat
1641891Alcrsp17Alcohol response QTL 17response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2149559561249053267Rat
724534Uae6Urinary albumin excretion QTL 610urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)278665619249053267Rat
61374Edpm2Estrogen-dependent pituitary mass QTL 24.420.86pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)276539322202447032Rat
2300189Bmd48Bone mineral density QTL 485.80.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)2179335906224335906Rat
8662843Vetf9Vascular elastic tissue fragility QTL 92.05thoracic aorta molecular composition trait (VT:0010568)aorta wall extracellular elastin dry weight to aorta wall extracellular collagen weight ratio (CMO:0002003)2157142078226277316Rat
2301408Kidm36Kidney mass QTL 360.002kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)2190613715226808892Rat
631501Bp101Blood pressure QTL 1012.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2150341684202446871Rat
2307174Activ3Activity QTL 34.830.000058locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)2168594495213594495Rat
1331794Bp202Blood pressure QTL 2023.66819arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2141194931223265385Rat
71113Cari2Carrageenan-induced inflammation QTL 22.70.009hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)2141596551202447032Rat
1331805Cm29Cardiac mass QTL 293.50746heart mass (VT:0007028)heart wet weight (CMO:0000069)2141194931223265385Rat
634308Sach6Saccharin preference QTL 64.9taste sensitivity trait (VT:0001986)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)2112456140212696837Rat
1358917Cm42Cardiac mass QTL 422.82heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
724568Uae13Urinary albumin excretion QTL 134.4urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)2143157029210020885Rat
1358913Cm41Cardiac mass QTL 412.73heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
1300165Rf9Renal function QTL 93.28kidney glomerulus integrity trait (VT:0010546)index of glomerular damage (CMO:0001135)2133914684202447032Rat
738013Alc15Alcohol consumption QTL 154.10.00022consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)2184165752229165752Rat
61398Bp50Blood pressure QTL 504.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2189599258234599258Rat
631507Bp105Blood pressure QTL 1050.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2112456140212696837Rat
1641925Alcrsp2Alcohol response QTL 2response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2149559561221167075Rat
1354609Niddm62Non-insulin dependent diabetes mellitus QTL 624.720.000006insulin secretion trait (VT:0003564)plasma insulin level (CMO:0000342)2150540301202447032Rat
61417Cia10Collagen induced arthritis QTL 103.4joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)2179946951224946951Rat
1354622Kidm16Kidney mass QTL 163kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)281754530222436696Rat
631266Bp132Blood pressure QTL 1320.0005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)246123260202447032Rat
8694383Bw158Body weight QTL 1587.690.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)2182171407227171407Rat
7488927Bp365Blood pressure QTL 3650.008arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2162765032207765032Rat
1598838Bp290Blood pressure QTL 2901.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2166539266211539266Rat
7488925Bp364Blood pressure QTL 3640.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2160564068205564068Rat
2306901Bp337Blood pressure QTL 3370.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2164073756227146641Rat
1354605Rf48Renal function QTL 482.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)274786664206665859Rat
2293084Iddm26Insulin dependent diabetes mellitus QTL 262.9blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2174930955213594495Rat

Markers in Region
KCNA2_869  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22194,708,480 - 194,709,316 (+)MAPPERmRatBN7.2
Rnor_6.02209,842,565 - 209,843,400NCBIRnor6.0
Rnor_5.02229,307,375 - 229,308,210UniSTSRnor5.0
RGSC_v3.42202,563,322 - 202,564,157UniSTSRGSC3.4
Celera2187,369,379 - 187,370,214UniSTS
Cytogenetic Map2q34UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 7 38
Low 19 23 12 12 12 7 7 26 24 30 9 7
Below cutoff 2 14 26 21 21 1 2 10 9 11 2 1

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_012970 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006233132 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006233133 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006233134 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006233135 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008761371 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039101795 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039101797 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063281362 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063281363 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063281364 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC113635 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473952 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ213529 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ233516 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  J04731 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000002 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M74449 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000050149   ⟹   ENSRNOP00000042653
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl2209,840,404 - 209,843,649 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000086836   ⟹   ENSRNOP00000074851
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl2209,849,848 - 209,850,102 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000092365   ⟹   ENSRNOP00000075841
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl2209,838,869 - 209,843,588 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000092450   ⟹   ENSRNOP00000075852
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2194,705,199 - 194,718,400 (+)Ensembl
Rnor_6.0 Ensembl2209,839,299 - 209,852,471 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000100022   ⟹   ENSRNOP00000089201
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2194,704,639 - 194,718,400 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000108979   ⟹   ENSRNOP00000079590
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2194,704,888 - 194,718,400 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000116262   ⟹   ENSRNOP00000090952
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2194,705,683 - 194,718,400 (+)Ensembl
RefSeq Acc Id: NM_012970   ⟹   NP_037102
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82197,393,530 - 197,397,683 (+)NCBI
mRatBN7.22194,705,311 - 194,709,464 (+)NCBI
Rnor_6.02209,839,395 - 209,843,548 (+)NCBI
Rnor_5.02229,303,490 - 229,316,755 (+)NCBI
RGSC_v3.42202,560,152 - 202,564,305 (+)RGD
Celera2187,366,228 - 187,370,362 (+)RGD
Sequence:
RefSeq Acc Id: XM_006233132   ⟹   XP_006233194
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82197,393,950 - 197,406,606 (+)NCBI
mRatBN7.22194,705,727 - 194,718,387 (+)NCBI
Rnor_6.02209,839,810 - 209,852,471 (+)NCBI
Rnor_5.02229,303,490 - 229,316,755 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006233133   ⟹   XP_006233195
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82197,392,746 - 197,406,606 (+)NCBI
mRatBN7.22194,704,555 - 194,718,387 (+)NCBI
Rnor_6.02209,838,607 - 209,852,471 (+)NCBI
Rnor_5.02229,303,490 - 229,316,755 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006233134   ⟹   XP_006233196
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82197,392,973 - 197,406,606 (+)NCBI
mRatBN7.22194,704,879 - 194,718,387 (+)NCBI
Rnor_6.02209,838,891 - 209,852,471 (+)NCBI
Rnor_5.02229,303,490 - 229,316,755 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008761371   ⟹   XP_008759593
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82197,393,711 - 197,406,606 (+)NCBI
mRatBN7.22194,705,493 - 194,718,387 (+)NCBI
Rnor_6.02209,839,520 - 209,852,471 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039101795   ⟹   XP_038957723
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82197,393,950 - 197,406,606 (+)NCBI
mRatBN7.22194,705,727 - 194,718,387 (+)NCBI
RefSeq Acc Id: XM_039101797   ⟹   XP_038957725
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82197,393,950 - 197,406,606 (+)NCBI
mRatBN7.22194,705,727 - 194,718,387 (+)NCBI
RefSeq Acc Id: XM_063281362   ⟹   XP_063137432
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82197,393,353 - 197,406,606 (+)NCBI
RefSeq Acc Id: XM_063281363   ⟹   XP_063137433
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82197,392,776 - 197,406,606 (+)NCBI
RefSeq Acc Id: XM_063281364   ⟹   XP_063137434
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82197,393,711 - 197,406,606 (+)NCBI
RefSeq Acc Id: NP_037102   ⟸   NM_012970
- UniProtKB: Q02010 (UniProtKB/Swiss-Prot),   P15386 (UniProtKB/Swiss-Prot),   P63142 (UniProtKB/Swiss-Prot),   A6HUS5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006233195   ⟸   XM_006233133
- Peptide Label: isoform X1
- UniProtKB: Q02010 (UniProtKB/Swiss-Prot),   P15386 (UniProtKB/Swiss-Prot),   P63142 (UniProtKB/Swiss-Prot),   A6HUS5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006233196   ⟸   XM_006233134
- Peptide Label: isoform X1
- UniProtKB: Q02010 (UniProtKB/Swiss-Prot),   P15386 (UniProtKB/Swiss-Prot),   P63142 (UniProtKB/Swiss-Prot),   A6HUS5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006233194   ⟸   XM_006233132
- Peptide Label: isoform X1
- UniProtKB: Q02010 (UniProtKB/Swiss-Prot),   P15386 (UniProtKB/Swiss-Prot),   P63142 (UniProtKB/Swiss-Prot),   A6HUS5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008759593   ⟸   XM_008761371
- Peptide Label: isoform X1
- UniProtKB: Q02010 (UniProtKB/Swiss-Prot),   P15386 (UniProtKB/Swiss-Prot),   P63142 (UniProtKB/Swiss-Prot),   A6HUS5 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000075841   ⟸   ENSRNOT00000092365
Ensembl Acc Id: ENSRNOP00000075852   ⟸   ENSRNOT00000092450
Ensembl Acc Id: ENSRNOP00000074851   ⟸   ENSRNOT00000086836
Ensembl Acc Id: ENSRNOP00000042653   ⟸   ENSRNOT00000050149
RefSeq Acc Id: XP_038957725   ⟸   XM_039101797
- Peptide Label: isoform X1
- UniProtKB: P63142 (UniProtKB/Swiss-Prot),   Q02010 (UniProtKB/Swiss-Prot),   P15386 (UniProtKB/Swiss-Prot),   A6HUS5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038957723   ⟸   XM_039101795
- Peptide Label: isoform X1
- UniProtKB: P63142 (UniProtKB/Swiss-Prot),   Q02010 (UniProtKB/Swiss-Prot),   P15386 (UniProtKB/Swiss-Prot),   A6HUS5 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000079590   ⟸   ENSRNOT00000108979
Ensembl Acc Id: ENSRNOP00000089201   ⟸   ENSRNOT00000100022
Ensembl Acc Id: ENSRNOP00000090952   ⟸   ENSRNOT00000116262
RefSeq Acc Id: XP_063137433   ⟸   XM_063281363
- Peptide Label: isoform X1
- UniProtKB: P63142 (UniProtKB/Swiss-Prot),   Q02010 (UniProtKB/Swiss-Prot),   P15386 (UniProtKB/Swiss-Prot),   A6HUS5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063137432   ⟸   XM_063281362
- Peptide Label: isoform X1
- UniProtKB: P63142 (UniProtKB/Swiss-Prot),   Q02010 (UniProtKB/Swiss-Prot),   P15386 (UniProtKB/Swiss-Prot),   A6HUS5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063137434   ⟸   XM_063281364
- Peptide Label: isoform X1
- UniProtKB: P63142 (UniProtKB/Swiss-Prot),   Q02010 (UniProtKB/Swiss-Prot),   P15386 (UniProtKB/Swiss-Prot),   A6HUS5 (UniProtKB/TrEMBL)
Protein Domains
BTB

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P63142-F1-model_v2 AlphaFold P63142 1-499 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2950 AgrOrtholog
BioCyc Gene G2FUF-51688 BioCyc
Ensembl Genes ENSRNOG00000018285 Ensembl, UniProtKB/Swiss-Prot
  ENSRNOG00055020280 UniProtKB/Swiss-Prot
  ENSRNOG00060029911 UniProtKB/Swiss-Prot
  ENSRNOG00065022931 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000092450.2 UniProtKB/Swiss-Prot
  ENSRNOT00000100022.1 UniProtKB/Swiss-Prot
  ENSRNOT00000108979.1 UniProtKB/Swiss-Prot
  ENSRNOT00000116262.1 UniProtKB/Swiss-Prot
  ENSRNOT00055034634 UniProtKB/Swiss-Prot
  ENSRNOT00055034637 UniProtKB/Swiss-Prot
  ENSRNOT00055034641 UniProtKB/Swiss-Prot
  ENSRNOT00055034645 UniProtKB/Swiss-Prot
  ENSRNOT00060051941 UniProtKB/Swiss-Prot
  ENSRNOT00060051956 UniProtKB/Swiss-Prot
  ENSRNOT00060051963 UniProtKB/Swiss-Prot
  ENSRNOT00060051970 UniProtKB/Swiss-Prot
  ENSRNOT00065039166 UniProtKB/Swiss-Prot
  ENSRNOT00065039168 UniProtKB/Swiss-Prot
  ENSRNOT00065039175 UniProtKB/Swiss-Prot
  ENSRNOT00065039180 UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.287.70 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  1.20.120.350 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro BTB/POZ_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ion_trans_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  K_chnl_volt-dep_Kv UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  K_chnl_volt-dep_Kv1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  K_chnl_volt-dep_Kv1.2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SKP1/BTB/POZ_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  T1-type_BTB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Volt_channel_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:25468 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 25468 ENTREZGENE
PANTHER POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY A MEMBER 2 UniProtKB/TrEMBL
  PTHR11537 UniProtKB/Swiss-Prot
  PTHR11537:SF23 UniProtKB/Swiss-Prot
  VOLTAGE-GATED POTASSIUM CHANNEL UniProtKB/TrEMBL
Pfam BTB_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ion_trans UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Kcna2 PhenoGen
PRINTS KCHANNEL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  KV12CHANNEL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  KVCHANNEL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SHAKERCHANEL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000018285 RatGTEx
  ENSRNOG00055020280 RatGTEx
  ENSRNOG00060029911 RatGTEx
  ENSRNOG00065022931 RatGTEx
SMART BTB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP POZ domain UniProtKB/TrEMBL, UniProtKB/Swiss-Prot
  Voltage-gated potassium channels UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A6HUS4_RAT UniProtKB/TrEMBL
  A6HUS5 ENTREZGENE, UniProtKB/TrEMBL
  KCNA2_RAT UniProtKB/Swiss-Prot
  P15386 ENTREZGENE
  P63142 ENTREZGENE
  Q02010 ENTREZGENE
UniProt Secondary P15386 UniProtKB/Swiss-Prot
  Q02010 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-11 Kcna2  potassium voltage-gated channel subfamily A member 2  Kcna2  potassium channel, voltage gated shaker related subfamily A, member 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2015-01-26 Kcna2  potassium channel, voltage gated shaker related subfamily A, member 2  Kcna2  potassium voltage-gated channel, shaker-related subfamily, member 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-11-06 Kcna2  potassium voltage-gated channel, shaker-related subfamily, member 2    potassium voltage gated channel, shaker related subfamily, member 2   Symbol and Name updated 625702 APPROVED
2002-06-10 Kcna2  potassium voltage gated channel, shaker related subfamily, member 2       Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference