Gene: KCNA2 (potassium voltage-gated channel subfamily A member 2) Homo sapiens
Symbol: KCNA2
Name: potassium voltage-gated channel subfamily A member 2
Description: Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member contains six membrane-spanning domains with a shaker-type repeat in the fourth segment. It belongs to the delayed rectifier class, members of which allow nerve cells to efficiently repolarize following an action potential. The coding region of this gene is intronless, and the gene is clustered with genes KCNA3 and KCNA10 on chromosome 1. [provided by RefSeq, Jul 2008]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: EIEE32; HBK5; HK4; HUKIV; KV1.2; MGC50217; MK2; NGK1; OTTHUMP00000013287; OTTHUMP00000234759; potassium channel; potassium channel, voltage gated shaker related subfamily A, member 2; potassium voltage-gated channel, shaker-related subfamily, member 2; RBK2; voltage-gated K(+) channel HuKIV; voltage-gated potassium channel HBK5; voltage-gated potassium channel protein Kv1.2; voltage-gated potassium channel subunit Kv1.2
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh381110,593,580 - 110,631,536 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371111,136,202 - 111,174,096 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361110,947,299 - 110,949,868 (-)NCBINCBI36hg18NCBI36
Build 341110,857,818 - 110,860,387NCBI
Celera1109,392,891 - 109,395,460 (-)NCBI
Cytogenetic Map1p13.3NCBI
HuRef1109,007,594 - 109,045,483 (-)NCBIHuRef
CHM1_11111,251,494 - 111,289,381 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
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References - curated
References - uncurated
RGD Disease Portals


Comparative Map Data
Position Markers
miRNA Target Status


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on KCNA2
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
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RGD Object Information
RGD ID: 735518
Created: 2004-02-06
Species: Homo sapiens
Last Modified: 2019-02-19
Status: ACTIVE