Kif5b (kinesin family member 5B) - Rat Genome Database

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Gene: Kif5b (kinesin family member 5B) Rattus norvegicus
Analyze
Symbol: Kif5b
Name: kinesin family member 5B
RGD ID: 621559
Description: Enables JUN kinase binding activity; microtubule lateral binding activity; and microtubule motor activity. Involved in axonal transport; hippocampus development; and positive regulation of transport. Located in axonal growth cone; microtubule cytoskeleton; and perinuclear region of cytoplasm. Orthologous to human KIF5B (kinesin family member 5B); PARTICIPATES IN insulin responsive facilitative sugar transporter mediated glucose transport pathway; mitochondria transport pathway; N-cadherin signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene; 2,6-dinitrotoluene.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: conventional kinesin heavy chain; Khc; kinesin-1 heavy chain; ubiquitous kinesin heavy chain; UKHC
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21751,489,873 - 51,527,508 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1751,489,944 - 51,527,508 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1754,663,892 - 54,694,120 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01758,666,828 - 58,697,056 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01752,804,979 - 52,835,181 (+)NCBIRnor_WKY
Rnor_6.01754,181,416 - 54,219,048 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1754,181,419 - 54,212,096 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01751,875,803 - 51,913,435 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41759,697,082 - 59,727,314 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11759,728,937 - 59,735,497 (+)NCBI
Celera1747,501,097 - 47,531,289 (+)NCBICelera
Cytogenetic Map17q12.1NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Diabetes alters KIF1A and KIF5B motor proteins in the hippocampus. Baptista FI, etal., PLoS One. 2013 Jun 12;8(6):e65515. doi: 10.1371/journal.pone.0065515. Print 2013.
2. Activation of conventional kinesin motors in clusters by Shaw voltage-gated K+ channels. Barry J, etal., J Cell Sci. 2013 May 1;126(Pt 9):2027-41. doi: 10.1242/jcs.122234. Epub 2013 Mar 13.
3. Association of dystrobrevin and regulatory subunit of protein kinase A: a new role for dystrobrevin as a scaffold for signaling proteins. Ceccarini M, etal., J Mol Biol. 2007 Aug 31;371(5):1174-87. doi: 10.1016/j.jmb.2007.06.019. Epub 2007 Jun 14.
4. Axonal guidance protein FEZ1 associates with tubulin and kinesin motor protein to transport mitochondria in neurites of NGF-stimulated PC12 cells. Fujita T, etal., Biochem Biophys Res Commun. 2007 Sep 28;361(3):605-10. Epub 2007 Jul 23.
5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
7. MAP2 Defines a Pre-axonal Filtering Zone to Regulate KIF1- versus KIF5-Dependent Cargo Transport in Sensory Neurons. Gumy LF, etal., Neuron. 2017 Apr 19;94(2):347-362.e7. doi: 10.1016/j.neuron.2017.03.046.
8. Daxx functions as a scaffold of a protein assembly constituted by GLUT4, JNK1 and KIF5B. Lalioti VS, etal., J Cell Physiol. 2009 Feb;218(2):416-26. doi: 10.1002/jcp.21614.
9. A direct interaction between cytoplasmic dynein and kinesin I may coordinate motor activity. Ligon LA, etal., J Biol Chem. 2004 Apr 30;279(18):19201-8. Epub 2004 Feb 24.
10. Regulation of mitochondrial transport in neurons. Lin MY and Sheng ZH, Exp Cell Res. 2015 May 15;334(1):35-44. doi: 10.1016/j.yexcr.2015.01.004. Epub 2015 Jan 19.
11. Membrane damage-induced vesicle-vesicle fusion of dysferlin-containing vesicles in muscle cells requires microtubules and kinesin. McDade JR and Michele DE, Hum Mol Genet. 2014 Apr 1;23(7):1677-86. doi: 10.1093/hmg/ddt557. Epub 2013 Nov 7.
12. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
13. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
14. Glucose regulates mitochondrial motility via Milton modification by O-GlcNAc transferase. Pekkurnaz G, etal., Cell. 2014 Jul 3;158(1):54-68. doi: 10.1016/j.cell.2014.06.007.
15. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
16. GOA pipeline RGD automated data pipeline
17. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
18. The role of Kif5B in axonal localization of Kv1 K(+) channels. Rivera J, etal., Eur J Neurosci. 2007 Jan;25(1):136-46.
19. Surface-decoration of microtubules by human tau. Santarella RA, etal., J Mol Biol. 2004 Jun 4;339(3):539-53.
20. Rho GTPases in insulin-stimulated glucose uptake. Satoh T Small GTPases. 2014;5:e28102. doi: 10.4161/sgtp.28102. Epub 2014 Mar 10.
21. KIF5B promotes the forward transport and axonal function of the voltage-gated sodium channel Nav1.8. Su YY, etal., J Neurosci. 2013 Nov 6;33(45):17884-96. doi: 10.1523/JNEUROSCI.0539-13.2013.
22. c-Jun NH2-terminal kinase (JNK)-interacting protein-3 (JIP3) regulates neuronal axon elongation in a kinesin- and JNK-dependent manner. Sun T, etal., J Biol Chem. 2013 May 17;288(20):14531-43. doi: 10.1074/jbc.M113.464453. Epub 2013 Apr 10.
23. Targeted disruption of mouse conventional kinesin heavy chain, kif5B, results in abnormal perinuclear clustering of mitochondria. Tanaka Y, etal., Cell 1998 Jun 26;93(7):1147-58.
24. Molecular motors implicated in the axonal transport of tau and alpha-synuclein. Utton MA, etal., J Cell Sci. 2005 Oct 15;118(Pt 20):4645-54. Epub 2005 Sep 21.
25. Expression of neuronal kinesin heavy chain is developmentally regulated in the central nervous system of the rat. Vignali G, etal., J Neurochem. 1997 Nov;69(5):1840-9.
26. Defective mitophagy driven by dysregulation of rheb and KIF5B contributes to mitochondrial reactive oxygen species (ROS)-induced nod-like receptor 3 (NLRP3) dependent proinflammatory response and aggravates lipotoxicity. Yang S, etal., Redox Biol. 2014;3:63-71. doi: 10.1016/j.redox.2014.04.001. Epub 2014 Apr 12.
Additional References at PubMed
PMID:7514426   PMID:10573845   PMID:12805290   PMID:15644324   PMID:16018997   PMID:16260607   PMID:16301330   PMID:17013387   PMID:17200414   PMID:17200416   PMID:17360972   PMID:17611281  
PMID:17887960   PMID:18004302   PMID:19144319   PMID:19675065   PMID:19825938   PMID:19828815   PMID:19946888   PMID:20152113   PMID:20386726   PMID:20682791   PMID:20863816   PMID:21048148  
PMID:25002582   PMID:25468996   PMID:25644797   PMID:26316108   PMID:26656703   PMID:27094714   PMID:27219061   PMID:29476059   PMID:30053369   PMID:30978476   PMID:33953268   PMID:34154701  


Genomics

Comparative Map Data
Kif5b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21751,489,873 - 51,527,508 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1751,489,944 - 51,527,508 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1754,663,892 - 54,694,120 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01758,666,828 - 58,697,056 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01752,804,979 - 52,835,181 (+)NCBIRnor_WKY
Rnor_6.01754,181,416 - 54,219,048 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1754,181,419 - 54,212,096 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01751,875,803 - 51,913,435 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41759,697,082 - 59,727,314 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11759,728,937 - 59,735,497 (+)NCBI
Celera1747,501,097 - 47,531,289 (+)NCBICelera
Cytogenetic Map17q12.1NCBI
KIF5B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381032,009,015 - 32,056,425 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1032,009,015 - 32,056,425 (-)EnsemblGRCh38hg38GRCh38
GRCh371032,297,943 - 32,345,353 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361032,340,077 - 32,385,221 (-)NCBINCBI36Build 36hg18NCBI36
Build 341032,340,076 - 32,385,221NCBI
Celera1032,062,826 - 32,110,627 (-)NCBICelera
Cytogenetic Map10p11.22NCBI
HuRef1032,018,111 - 32,065,919 (-)NCBIHuRef
CHM1_11032,299,660 - 32,347,071 (-)NCBICHM1_1
T2T-CHM13v2.01032,037,647 - 32,085,426 (-)NCBIT2T-CHM13v2.0
Kif5b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39186,201,005 - 6,241,524 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl186,201,002 - 6,242,174 (-)EnsemblGRCm39 Ensembl
GRCm38186,201,005 - 6,241,524 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl186,201,002 - 6,242,174 (-)EnsemblGRCm38mm10GRCm38
MGSCv37186,201,003 - 6,241,522 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36186,202,209 - 6,241,498 (-)NCBIMGSCv36mm8
Celera186,247,889 - 6,288,660 (-)NCBICelera
Cytogenetic Map18A1NCBI
cM Map184.46NCBI
Kif5b
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542923,631,282 - 23,678,562 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542923,632,246 - 23,678,797 (-)NCBIChiLan1.0ChiLan1.0
KIF5B
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11032,731,150 - 32,778,242 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1032,731,150 - 32,778,242 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01032,138,964 - 32,186,448 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
KIF5B
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1214,835,906 - 14,880,896 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl214,835,901 - 14,878,251 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha212,323,571 - 12,368,548 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0213,072,118 - 13,117,087 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl213,072,118 - 13,116,722 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1212,512,247 - 12,557,211 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0212,403,006 - 12,447,970 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0212,676,797 - 12,721,749 (+)NCBIUU_Cfam_GSD_1.0
Kif5b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934411,280,577 - 11,324,435 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936574779,777 - 823,970 (-)EnsemblSpeTri2.0
SpeTri2.0NW_004936574780,074 - 823,858 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
KIF5B
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1042,637,109 - 42,693,491 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11042,637,105 - 42,693,551 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21047,233,047 - 47,293,409 (-)NCBISscrofa10.2Sscrofa10.2susScr3
KIF5B
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1931,321,615 - 31,369,549 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl931,320,549 - 31,369,519 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605640,295,395 - 40,343,097 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Kif5b
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248054,465,235 - 4,514,870 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248054,464,538 - 4,514,784 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Kif5b
78 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:31
Count of miRNA genes:28
Interacting mature miRNAs:30
Transcripts:ENSRNOT00000023861
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354658Spl8Serum phospholipid level QTL 83.8blood VLDL phospholipid amount (VT:0010507)blood very low density lipoprotein phospholipid level (CMO:0001571)17160781592Rat
1354581Bp247Blood pressure QTL 2474.5arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)17169599340Rat
1354662Rf49Renal function QTL 492.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)17169599340Rat
1354596Bw32Body weight QTL 324.5body mass (VT:0001259)body weight (CMO:0000012)17429913060781592Rat
1354630Cm34Cardiac mass QTL 348.7heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)17429913069599340Rat
1354638Insul1Insulin level QTL 14.8blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)17429913069599340Rat
1354651Lmblg2Limb length QTL 26tibia length (VT:0004357)tibia length (CMO:0000450)17429913069599340Rat
2303561Bw91Body weight QTL 912body mass (VT:0001259)body weight (CMO:0000012)17886846253868462Rat
1331765Hrtrt15Heart rate QTL 154.094heart pumping trait (VT:2000009)heart rate (CMO:0000002)171533061355836425Rat
1354640Scl32Serum cholesterol level QTL 325.4blood HDL cholesterol amount (VT:0000184)blood high density lipoprotein cholesterol level (CMO:0000052)171578159260781592Rat
1354659Scl68Serum cholesterol level QTL 683.9blood VLDL cholesterol amount (VT:0005144)blood very low density lipoprotein cholesterol level (CMO:0000648)171578159260781592Rat
7394837Memor18Memory QTL 18exploratory behavior trait (VT:0010471)measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)171864018263640182Rat
1354628Stl13Serum triglyceride level QTL 133.8blood triglyceride amount (VT:0002644)blood triglyceride level (CMO:0000118)172129303960781592Rat
61394Bp8Blood pressure QTL 82.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)172308056759555013Rat
7488966Bp370Blood pressure QTL 3700.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)172365318457246843Rat
12903978Cm118Cardiac mass QTL 1180.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)172365318468653184Rat
12903979Cm119Cardiac mass QTL 1190.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)172365318468653184Rat
12903980Cm120Cardiac mass QTL 1200.002heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)172365318468653184Rat
12903981Am17Aortic mass QTL 170.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)172365318468653184Rat
1559055Bp278Blood pressure QTL 2780.04arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)172365318468653184Rat
12903982Kidm70Kidney mass QTL 700.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)172365318470974005Rat
1354619Bp242Blood pressure QTL 2426.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)172459934069599340Rat
1581512Cm55Cardiac mass QTL 552.80.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)172702794956836890Rat
4889955Bss93Bone structure and strength QTL 934.4tibia size trait (VT:0100001)tibia cortical bone volume to tibia total bone volume ratio (CMO:0001727)172702794960463643Rat
2302377Scl61Serum cholesterol level QTL 614.36blood HDL cholesterol amount (VT:0000184)serum high density lipoprotein cholesterol level (CMO:0000361)172738994653481766Rat
8552928Pigfal9Plasma insulin-like growth factor 1 level QTL 99blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)172840914773409147Rat
9590107Sffal7Serum free fatty acids level QTL 74.810.001blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)172840914773409147Rat
10450503Bp386Blood pressure QTL 3860.28arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)173136839162109574Rat
2324621Coatc5Coat color QTL 5coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)173136839173951021Rat
724549Niddm56Non-insulin dependent diabetes mellitus QTL 560.03blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)173199078476990784Rat
1354663Bvd5Brain ventricular dilatation QTL 53.510.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)173199078481292925Rat
1300148Bp192Blood pressure QTL 1923.47arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)173455084373951021Rat
724528Uae4Urinary albumin excretion QTL 44.90.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)173583708569599340Rat
2301412Kidm40Kidney mass QTL 400.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)173747984782479847Rat
2317054Aia12Adjuvant induced arthritis QTL 124.24joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)173828150983281509Rat
2317060Aia26Adjuvant induced arthritis QTL 263.22joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)173828150983281509Rat
1598871Memor5Memory QTL 55.3exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)174054004180387013Rat
1358295Aocep1Aortic cell protein QTL 16.10.00000071thoracic aorta cellular protein amount (VT:0010598)aortic cell percentage174099000585990005Rat
631497Bp98Blood pressure QTL 983.66arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)174135465160463643Rat
1354635Bp245Blood pressure QTL 2456arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)174207316069599340Rat
1354635Bp245Blood pressure QTL 2456arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)174207316069599340Rat
7411575Bw140Body weight QTL 14030.20.001body mass (VT:0001259)body weight gain (CMO:0000420)174856093586533673Rat
8694181Bw151Body weight QTL 1514.360.001body mass (VT:0001259)body weight gain (CMO:0000420)174856093586533673Rat
2317038Ginf3Gastrointestinal inflammation QTL 32.890.005liver integrity trait (VT:0010547)liver granuloma severity score (CMO:0002157)174992015486533673Rat
2303580Gluco49Glucose level QTL 492blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)175004027186533673Rat
1354629Scl31Serum cholesterol level QTL 314.1blood cholesterol amount (VT:0000180)blood total cholesterol level (CMO:0000051)175089090860781592Rat
1354654Spl7Serum phospholipid level QTL 75.5blood phospholipid amount (VT:0006084)blood phospholipid level (CMO:0001169)175089090860781592Rat
4889894Eae33Experimental allergic encephalomyelitis QTL 335.20.0001nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)175090909986022412Rat
2317053Aia25Adjuvant induced arthritis QTL 252.69joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)175090919660781426Rat

Markers in Region
RH128765  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21751,520,627 - 51,520,825 (+)MAPPERmRatBN7.2
Rnor_6.01754,212,168 - 54,212,365NCBIRnor6.0
Rnor_5.01751,906,555 - 51,906,752UniSTSRnor5.0
RGSC_v3.41759,727,403 - 59,727,600UniSTSRGSC3.4
Celera1747,531,378 - 47,531,575UniSTS
Cytogenetic Map17q12.1UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 43 56 40 19 40 8 10 74 35 41 11 8
Low 1 1 1 1
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_057202 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006254005 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AF155822 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ309275 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ214771 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ226753 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ227129 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ227346 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ230391 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ232221 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ233191 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ233216 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ234099 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ234494 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ235192 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ235294 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JACYVU010000293 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000023861   ⟹   ENSRNOP00000023860
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1751,489,944 - 51,527,508 (+)Ensembl
Rnor_6.0 Ensembl1754,181,419 - 54,212,096 (+)Ensembl
RefSeq Acc Id: NM_057202   ⟹   NP_476550
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21751,490,307 - 51,520,539 (+)NCBI
Rnor_6.01754,181,847 - 54,212,079 (+)NCBI
Rnor_5.01751,875,803 - 51,913,435 (+)NCBI
RGSC_v3.41759,697,082 - 59,727,314 (+)RGD
Celera1747,501,097 - 47,531,289 (+)RGD
Sequence:
RefSeq Acc Id: XM_006254005   ⟹   XP_006254067
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21751,489,873 - 51,527,508 (+)NCBI
Rnor_6.01754,181,416 - 54,219,048 (+)NCBI
Rnor_5.01751,875,803 - 51,913,435 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_476550 (Get FASTA)   NCBI Sequence Viewer  
  XP_006254067 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAD39239 (Get FASTA)   NCBI Sequence Viewer  
  ABC25059 (Get FASTA)   NCBI Sequence Viewer  
  Q2PQA9 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_476550   ⟸   NM_057202
- UniProtKB: Q9WV65 (UniProtKB/Swiss-Prot),   Q2PQA9 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006254067   ⟸   XM_006254005
- Peptide Label: isoform X1
- UniProtKB: Q2PQA9 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000023860   ⟸   ENSRNOT00000023861
Protein Domains
Kinesin motor

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q2PQA9-F1-model_v2 AlphaFold Q2PQA9 1-963 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13700522
Promoter ID:EPDNEW_R11043
Type:initiation region
Name:Kif5b_1
Description:kinesin family member 5B
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01754,181,444 - 54,181,504EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621559 AgrOrtholog
BioCyc Gene G2FUF-9060 BioCyc
Ensembl Genes ENSRNOG00000017466 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000023860 ENTREZGENE
  ENSRNOP00000023860.5 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000023861 ENTREZGENE
  ENSRNOT00000023861.7 UniProtKB/TrEMBL
Gene3D-CATH 3.40.850.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Kinesin-like_fam UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kinesin_motor_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kinesin_motor_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kinesin_motor_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:117550 UniProtKB/Swiss-Prot
NCBI Gene 117550 ENTREZGENE
PANTHER PTHR24115 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Kinesin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Kif5b PhenoGen
PRINTS KINESINHEAVY UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE KINESIN_MOTOR_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  KINESIN_MOTOR_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART KISc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF52540 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8L2QCP8_RAT UniProtKB/TrEMBL
  KINH_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q9WV65 ENTREZGENE
UniProt Secondary Q9WV65 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-09-10 Kif5b  kinesin family member 5B      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Kif5b  kinesin family member 5B      Symbol and Name status set to provisional 70820 PROVISIONAL