Gene: Kcna5 (potassium voltage-gated channel subfamily A member 5) Rattus norvegicus
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Symbol: Kcna5
Name: potassium voltage-gated channel subfamily A member 5
Description: ENCODES a protein that exhibits delayed rectifier potassium channel activity; outward rectifier potassium channel activity; signaling receptor binding; INVOLVED IN negative regulation of cytosolic calcium ion concentration; positive regulation of G1/S transition of mitotic cell cycle; positive regulation of myoblast proliferation; PARTICIPATES IN acebutolol pharmacodynamics pathway; adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway; amiodarone pharmacodynamics pathway; ASSOCIATED WITH Diabetes Mellitus, Experimental ; Experimental Autoimmune Myocarditis; hypertension; FOUND IN endoplasmic reticulum; Golgi apparatus; integral component of plasma membrane; INTERACTS WITH (5Z,8Z,11Z,13E)-15-HETE; amiodarone; ammonium chloride
AGR Description: Exhibits delayed rectifier potassium channel activity, outward rectifier potassium channel activity, and signaling receptor binding activity; involved in several processes, including ion homeostasis, positive regulation of G1/S transition of mitotic cell cycle, and positive regulation of myoblast proliferation; localizes to several cellular components, including the cytoplasm, intercalated disc, and intracellular canaliculus; used to study pulmonary hypertension; biomarker of hypertension; orthologous to human KCNA5 (potassium voltage-gated channel subfamily A member 5).
Merged Description: Exhibits delayed rectifier potassium channel activity, outward rectifier potassium channel activity, and signaling receptor binding activity; involved in several processes, including ion homeostasis, positive regulation of G1/S transition of mitotic cell cycle, and positive regulation of myoblast proliferation; localizes to several cellular components, including the cytoplasm, intercalated disc, and intracellular canaliculus; used to study pulmonary hypertension; biomarker of hypertension; orthologous to human KCNA5 (potassium voltage-gated channel subfamily A member 5); PARTICIPATES IN acebutolol pharmacodynamics pathway; adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway; amiodarone pharmacodynamics pathway; INTERACTS WITH (5Z,8Z,11Z,13E)-15-HETE; amiodarone; ammonium chloride.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: Kv1; Kv1.5; potassium (K+) channel protein alpha 5; potassium channel, voltage gated shaker related subfamily A, member 5; potassium voltage gated channel shaker related subfamily member 5; potassium voltage gated channel, shaker related subfamily, member 5; potassium voltage-gated channel, shaker-related subfamily, member 5; RCK7; RK4; voltage-gated potassium channel subunit Kv1.5
Orthologs:
Allele / Splice: Kcna5m1Mcwi  
Genetic Models: SS-Kcna5m1Mcwi
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.04159,077,195 - 159,079,003 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.04226,075,051 - 226,076,859 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44162,896,283 - 162,898,091 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.14163,141,218 - 163,143,027 (-)NCBI
Celera4148,072,289 - 148,074,097 (-)NCBICelera
Cytogenetic Map4q42NCBI
RH 3.4 Map41009.3RGD
JBrowse: View Region in Genome Browser (JBrowse)
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Genomics

Comparative Map Data
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QTLs in Region (Rnor_6.0)
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Sequence

Nucleotide Sequences
Protein Sequences
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Strain Variation

Strain Sequence Variants (Rnor 5.0)
Damaging Variants

Additional Information

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Nomenclature History
RGD Curation Notes
 
More on Kcna5
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 2953
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2019-04-12
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.