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Gene: Kcna5 (potassium voltage-gated channel subfamily A member 5) Rattus norvegicus
Symbol: Kcna5
Name: potassium voltage-gated channel subfamily A member 5
Description: Exhibits delayed rectifier potassium channel activity; outward rectifier potassium channel activity; and signaling receptor binding activity. Involved in several processes, including metal ion homeostasis; positive regulation of G1/S transition of mitotic cell cycle; and potassium ion export across plasma membrane. Localizes to several cellular components, including Z disc; intercalated disc; and intracellular canaliculus. Used to study pulmonary hypertension. Biomarker of hypertension. Human ortholog(s) of this gene implicated in familial atrial fibrillation and pulmonary hypertension. Orthologous to human KCNA5 (potassium voltage-gated channel subfamily A member 5); PARTICIPATES IN acebutolol pharmacodynamics pathway; adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway; amiodarone pharmacodynamics pathway; INTERACTS WITH (5Z,8Z,11Z,13E)-15-HETE; 1-naphthyl isothiocyanate; amiodarone.
Type: protein-coding
Also known as: Kv1; Kv1.5; potassium (K+) channel protein alpha 5; potassium channel, voltage gated shaker related subfamily A, member 5; potassium voltage gated channel shaker related subfamily member 5; potassium voltage gated channel, shaker related subfamily, member 5; potassium voltage-gated channel, shaker-related subfamily, member 5; RCK7; RK4; voltage-gated potassium channel subunit Kv1.5
Allele / Splice: Kcna5m1Mcwi  
Genetic Models: SS-Kcna5m1Mcwi
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.04159,077,195 - 159,079,003 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4159,077,195 - 159,079,003 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04226,075,051 - 226,076,859 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44162,896,283 - 162,898,091 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.14163,141,218 - 163,143,027 (-)NCBI
Celera4148,072,289 - 148,074,097 (-)NCBICelera
Cytogenetic Map4q42NCBI
RH 3.4 Map41009.3RGD
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
Genetic Models
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Kcna5
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 2953
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2020-06-09
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.