Kcna5 (potassium voltage-gated channel subfamily A member 5) - Rat Genome Database

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Gene: Kcna5 (potassium voltage-gated channel subfamily A member 5) Rattus norvegicus
Analyze
Symbol: Kcna5
Name: potassium voltage-gated channel subfamily A member 5
RGD ID: 2953
Description: Enables delayed rectifier potassium channel activity; outward rectifier potassium channel activity; and signaling receptor binding activity. Involved in several processes, including positive regulation of G1/S transition of mitotic cell cycle; positive regulation of myoblast proliferation; and potassium ion export across plasma membrane. Located in several cellular components, including Z disc; intercalated disc; and intracellular canaliculus. Part of voltage-gated potassium channel complex. Used to study pulmonary hypertension. Biomarker of hypertension. Human ortholog(s) of this gene implicated in familial atrial fibrillation and pulmonary hypertension. Orthologous to human KCNA5 (potassium voltage-gated channel subfamily A member 5); PARTICIPATES IN acebutolol pharmacodynamics pathway; adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway; amiodarone pharmacodynamics pathway; INTERACTS WITH (5Z,8Z,11Z,13E)-15-HETE; 1-naphthyl isothiocyanate; allethrin.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Kv1; Kv1.5; potassium (K+) channel protein alpha 5; potassium channel, voltage gated shaker related subfamily A, member 5; potassium voltage gated channel shaker related subfamily member 5; potassium voltage gated channel, shaker related subfamily, member 5; potassium voltage-gated channel, shaker-related subfamily, member 5; RCK7; RK4; voltage-gated potassium channel subunit Kv1.5
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: Kcna5m1Mcwi  
Genetic Models: SS-Kcna5m1Mcwi
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84161,040,853 - 161,044,311 (-)NCBIGRCr8
mRatBN7.24159,354,689 - 159,358,173 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4159,350,097 - 159,357,697 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4165,584,496 - 165,587,452 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04161,367,410 - 161,370,366 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04160,001,429 - 160,004,385 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.04159,077,195 - 159,079,003 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4159,077,195 - 159,079,003 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04226,075,051 - 226,076,859 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44162,896,283 - 162,898,091 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.14163,141,218 - 163,143,027 (-)NCBI
Celera4148,072,289 - 148,074,097 (-)NCBICelera
RH 3.4 Map41009.3RGD
Cytogenetic Map4q42NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
acebutolol pharmacodynamics pathway   (ISO)
adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway  (ISO)
amiodarone pharmacodynamics pathway  (ISO)
amlodipine pharmacodynamics pathway  (ISO)
atenolol pharmacodynamics pathway  (ISO)
betaxolol pharmacodynamics pathway  (ISO)
bisoprolol pharmacodynamics pathway  (ISO)
bupranolol drug pathway  (ISO)
bupranolol pharmacodynamics pathway  (ISO)
carvedilol pharmacodynamics pathway  (ISO)
diltiazem pharmacodynamics pathway  (ISO)
disopyramide pharmacodynamics pathway  (ISO)
dobutamine pharmacodynamics pathway  (ISO)
esmolol pharmacodynamics pathway  (ISO)
flecainde pharmacodynamics pathway  (ISO)
fosphenytoin pharmacodynamics pathway  (ISO)
ibutilide pharmacodynamics pathway  (ISO)
isoprenaline pharmacodynamics pathway  (ISO)
isradipine pharmacodynamics pathway  (ISO)
levobunolol pharmacodynamics pathway  (ISO)
lidocaine pharmacodynamics pathway  (ISO)
metoprolol pharmacodynamics pathway  (ISO)
mexiletine pharmacodynamics pathway  (ISO)
nadolol pharmacodynamics pathway  (ISO)
nebivolol pharmacodynamics pathway  (ISO)
nifedipine pharmacodynamics pathway  (ISO)
nimodipine pharmacodynamics pathway  (ISO)
nisoldipine pharmacodynamics pathway  (ISO)
nitrendipine pharmacodynamics pathway  (ISO)
penbutolol pharmacodynamics pathway  (ISO)
phenytoin pharmacodynamics pathway  (ISO)
pindolol pharmacodynamics pathway  (ISO)
procainamide pharmacodynamics pathway  (ISO)
propranolol pharmacodynamics pathway  (ISO)
quinidine pharmacodynamics pathway  (ISO)
sotalol pharmacodynamics pathway  (ISO)
timolol pharmacodynamics pathway  (ISO)
verapamil pharmacodynamics pathway  (ISO)

References

References - curated
# Reference Title Reference Citation
1. An abnormal mitochondrial-hypoxia inducible factor-1alpha-Kv channel pathway disrupts oxygen sensing and triggers pulmonary arterial hypertension in fawn hooded rats: similarities to human pulmonary arterial hypertension. Bonnet S, etal., Circulation. 2006 Jun 6;113(22):2630-41. Epub 2006 May 30.
2. The nuclear factor of activated T cells in pulmonary arterial hypertension can be therapeutically targeted. Bonnet S, etal., Proc Natl Acad Sci U S A. 2007 Jul 3;104(27):11418-23. Epub 2007 Jun 27.
3. Molecular basis of dysfunctional Kv channels in small coronary artery smooth muscle cells of streptozotocin-induced diabetic rats. Chai Q, etal., Chin J Physiol. 2007 Aug 31;50(4):171-7.
4. Serotonin inhibits voltage-gated K+ currents in pulmonary artery smooth muscle cells: role of 5-HT2A receptors, caveolin-1, and KV1.5 channel internalization. Cogolludo A, etal., Circ Res. 2006 Apr 14;98(7):931-8. Epub 2006 Mar 9.
5. Differential expression of voltage-gated K(+) channel genes in arteries from spontaneously hypertensive and Wistar-Kyoto rats. Cox RH, etal., Hypertension. 2001 May;37(5):1315-22.
6. KMUP-1 ameliorates monocrotaline-induced pulmonary arterial hypertension through the modulation of Ca2+ sensitization and K+-channel. Dai ZK, etal., Life Sci. 2010 May 8;86(19-20):747-55. doi: 10.1016/j.lfs.2010.03.011. Epub 2010 Mar 19.
7. Normal targeting of a tagged Kv1.5 channel acutely transfected into fresh adult cardiac myocytes by a biolistic method. Dou Y, etal., Am J Physiol Cell Physiol. 2010 Jun;298(6):C1343-52. doi: 10.1152/ajpcell.00005.2010. Epub 2010 Mar 24.
8. Localization of Kv1.5 channels in rat and canine myocyte sarcolemma. Eldstrom J, etal., FEBS Lett. 2006 Nov 13;580(26):6039-46. Epub 2006 Oct 12.
9. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
10. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
11. Subacute hypoxia decreases voltage-activated potassium channel expression and function in pulmonary artery myocytes. Hong Z, etal., Am J Respir Cell Mol Biol. 2004 Sep;31(3):337-43. Epub 2004 May 19.
12. Evidence for proteasomal degradation of Kv1.5 channel protein. Kato M, etal., Biochem Biophys Res Commun. 2005 Nov 11;337(1):343-8.
13. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
14. Expression of delayed rectifier potassium channels and their possible roles in proliferation of human gastric cancer cells. Lan M, etal., Cancer Biol Ther. 2005 Dec;4(12):1342-7. Epub 2005 Dec 14.
15. Expression and characterization of delayed rectifying K+ channels in anterior rat taste buds. Liu L, etal., Am J Physiol Cell Physiol. 2005 Oct;289(4):C868-80. Epub 2005 Jun 1.
16. Contributions of Kv1.2, Kv1.5 and Kv2.1 subunits to the native delayed rectifier K(+) current in rat mesenteric artery smooth muscle cells. Lu Y, etal., Life Sci. 2002 Aug 9;71(12):1465-73.
17. Expression of IP3 receptor isoforms at the nodes of Ranvier in rat sciatic nerve. Martinez-Gomez A and Dent MA, Neuroreport. 2007 Mar 26;18(5):447-50.
18. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
19. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
20. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
21. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
22. Heteromultimeric Kv1 channels contribute to myogenic control of arterial diameter. Plane F, etal., Circ Res. 2005 Feb 4;96(2):216-24. Epub 2004 Dec 23.
23. Function of Kv1.5 channels and genetic variations of KCNA5 in patients with idiopathic pulmonary arterial hypertension. Remillard CV, etal., Am J Physiol Cell Physiol. 2007 May;292(5):C1837-53. Epub 2007 Jan 31.
24. GOA pipeline RGD automated data pipeline
25. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
26. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
27. Association and colocalization of the Kvbeta1 and Kvbeta2 beta-subunits with Kv1 alpha-subunits in mammalian brain K+ channel complexes. Rhodes KJ, etal., J Neurosci. 1997 Nov 1;17(21):8246-58.
28. Losartan prevents stretch-induced electrical remodeling in cultured atrial neonatal myocytes. Saygili E, etal., Am J Physiol Heart Circ Physiol. 2007 Jun;292(6):H2898-905. Epub 2007 Feb 9.
29. PDGF upregulates delayed rectifier via Src family kinases and sphingosine kinase in oligodendroglial progenitors. Soliven B, etal., Am J Physiol Cell Physiol 2003 Jan;284(1):C85-93.
30. Cloning and expression of cDNA and genomic clones encoding three delayed rectifier potassium channels in rat brain. Swanson R, etal., Neuron 1990 Jun;4(6):929-39.
31. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
32. Cell cycle-dependent expression of Kv1.5 is involved in myoblast proliferation. Villalonga N, etal., Biochim Biophys Acta. 2008 May;1783(5):728-36. doi: 10.1016/j.bbamcr.2008.01.001. Epub 2008 Jan 12.
33. Structural and electrical ventricular remodeling in rat acute myocarditis and subsequent heart failure. Wakisaka Y, etal., Cardiovasc Res. 2004 Sep 1;63(4):689-99.
34. Cibenzoline attenuates upregulation of Kv1.5 channel gene expression by experimental paroxysmal atrial fibrillation. Yamashita T, etal., Int Heart J. 2005 Mar;46(2):279-88.
Additional References at PubMed
PMID:1705709   PMID:1986382   PMID:7615797   PMID:8226976   PMID:8253777   PMID:8576199   PMID:8953041   PMID:10812072   PMID:11481235   PMID:12021261   PMID:12130714   PMID:12715100  
PMID:12970345   PMID:15217912   PMID:15277200   PMID:16051887   PMID:16236819   PMID:16713996   PMID:16731637   PMID:16780588   PMID:17525113   PMID:17526598   PMID:17660393   PMID:17699685  
PMID:18045854   PMID:18065659   PMID:18174882   PMID:18218624   PMID:18281375   PMID:18603586   PMID:18984061   PMID:19343045   PMID:19706553   PMID:21365420   PMID:22052159   PMID:22357486  
PMID:22547057   PMID:23117660   PMID:23185428   PMID:23264583   PMID:24077947   PMID:25451261   PMID:25661478   PMID:25808400   PMID:26286025   PMID:27062501   PMID:27522126   PMID:27958660  
PMID:28011270   PMID:30636484  


Genomics

Comparative Map Data
Kcna5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84161,040,853 - 161,044,311 (-)NCBIGRCr8
mRatBN7.24159,354,689 - 159,358,173 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4159,350,097 - 159,357,697 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4165,584,496 - 165,587,452 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04161,367,410 - 161,370,366 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04160,001,429 - 160,004,385 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.04159,077,195 - 159,079,003 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4159,077,195 - 159,079,003 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04226,075,051 - 226,076,859 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44162,896,283 - 162,898,091 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.14163,141,218 - 163,143,027 (-)NCBI
Celera4148,072,289 - 148,074,097 (-)NCBICelera
RH 3.4 Map41009.3RGD
Cytogenetic Map4q42NCBI
KCNA5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38125,043,879 - 5,046,788 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl125,043,879 - 5,046,788 (+)EnsemblGRCh38hg38GRCh38
GRCh37125,153,045 - 5,155,954 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36125,023,346 - 5,026,210 (+)NCBINCBI36Build 36hg18NCBI36
Build 34125,023,345 - 5,026,210NCBI
Celera126,774,165 - 6,777,029 (+)NCBICelera
Cytogenetic Map12p13.32NCBI
HuRef125,009,439 - 5,012,308 (+)NCBIHuRef
CHM1_1125,152,272 - 5,155,141 (+)NCBICHM1_1
T2T-CHM13v2.0125,050,280 - 5,053,156 (+)NCBIT2T-CHM13v2.0
Kcna5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm396126,509,514 - 126,512,518 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl6126,509,514 - 126,512,375 (-)EnsemblGRCm39 Ensembl
GRCm386126,532,551 - 126,535,555 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl6126,532,551 - 126,535,412 (-)EnsemblGRCm38mm10GRCm38
MGSCv376126,482,569 - 126,485,573 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv366126,498,172 - 126,501,031 (-)NCBIMGSCv36mm8
Celera6128,202,194 - 128,205,198 (-)NCBICelera
Cytogenetic Map6F3NCBI
cM Map661.35NCBI
Kcna5
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554132,836,146 - 2,837,966 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554132,835,730 - 2,838,761 (+)NCBIChiLan1.0ChiLan1.0
KCNA5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21010,595,714 - 10,598,602 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11210,592,469 - 10,595,360 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0125,165,057 - 5,168,307 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1125,083,877 - 5,086,739 (+)NCBIpanpan1.1PanPan1.1panPan2
KCNA5
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12739,808,987 - 39,810,789 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2739,756,363 - 39,811,035 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha276,870,413 - 6,872,215 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02740,165,046 - 40,166,848 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.12740,035,731 - 40,037,533 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02740,079,166 - 40,080,968 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0276,281,461 - 6,283,263 (+)NCBIUU_Cfam_GSD_1.0
KCNA5
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl565,439,336 - 65,442,207 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1565,439,336 - 65,442,207 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2567,652,617 - 67,655,142 (-)NCBISscrofa10.2Sscrofa10.2susScr3
KCNA5
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1115,085,221 - 5,088,135 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl115,085,518 - 5,087,335 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660633,158,446 - 3,161,477 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Kcna5
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248602,039,771 - 2,045,867 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248602,042,325 - 2,045,953 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Kcna5
10 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:67
Count of miRNA genes:55
Interacting mature miRNAs:63
Transcripts:ENSRNOT00000026691
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
6478754Anxrr43Anxiety related response QTL 430.14035locomotor behavior trait (VT:0001392)distance moved per unit of time into, out of or within a discrete space in an experimental apparatus (CMO:0001493)4144639524182687754Rat
724558Plsm2Polydactyly-luxate syndrome (PLS) morphotypes QTL 20.0003hindlimb integrity trait (VT:0010563)hind foot phalanges count (CMO:0001949)4132422778177422778Rat
1582237Kidm34Kidney mass QTL 3440.0001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)4148090542168069246Rat
6478693Anxrr32Anxiety related response QTL 320.00092locomotor behavior trait (VT:0001392)measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)4144639524182687754Rat
631683Bp116Blood pressure QTL 1160.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)4124303370169303370Rat
61451Ciaa4CIA Autoantibody QTL 43.1blood autoantibody amount (VT:0003725)calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)4126395976167139601Rat
1331738Bp209Blood pressure QTL 2092.979arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)4138503169179293946Rat
6478700Anxrr33Anxiety related response QTL 330.00896locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4144639524182687754Rat
1298524Oia8Oil induced arthritis QTL 8joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4138503169173369699Rat
10053718Scort25Serum corticosterone level QTL 252.150.0097blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)4155561574182687754Rat
1549827Scl46Serum cholesterol level QTL 463.5blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)4132396220177396220Rat
634335Anxrr16Anxiety related response QTL 167.22locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)493308457167139447Rat
737821Hcar9Hepatocarcinoma resistance QTL 93.7liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)4109866907167139601Rat
7411558Bw133Body weight QTL 13313.840.001body mass (VT:0001259)body weight gain (CMO:0000420)4125590636170590636Rat
6478778Anxrr51Anxiety related response QTL 510.25384locomotor behavior trait (VT:0001392)measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)4124778595169778595Rat
10401796Kidm48Kidney mass QTL 48kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)4145568712182687754Rat
6478718Anxrr34Anxiety related response QTL 340.00896locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4144639524182687754Rat
631511Pia7Pristane induced arthritis QTL 74.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4131730738167139601Rat
1300109Rf13Renal function QTL 133.91renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)4157710145182687754Rat
634347Hcar8Hepatocarcinoma resistance QTL 85.8liver integrity trait (VT:0010547)liver tumorous lesion area to total liver area ratio (CMO:0001075)4123143783168143783Rat
1576316Ept5Estrogen-induced pituitary tumorigenesis QTL 53.8pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)483428419177635233Rat
2303623Vencon2Ventilatory control QTL 23.8respiration trait (VT:0001943)minute ventilation (CMO:0000132)4135204660180204660Rat
1578674Bmd12Bone mineral density QTL 123.8femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)4135699135180699135Rat
1358202Gluco11Glucose level QTL 112.40.02adipocyte glucose uptake trait (VT:0004185)absolute change in adipocyte glucose uptake (CMO:0000873)485379421167139601Rat
61422Cia13Collagen induced arthritis QTL 134.5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4132642577167139601Rat
634342Cia24Collagen induced arthritis QTL 244.5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4146565735175236377Rat
737978Pia23Pristane induced arthritis QTL 235.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4131730738167139601Rat
61362Oia2Oil induced arthritis QTL 20.001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4138503169173369699Rat
12798519Anxrr54Anxiety related response QTL 542.540.05locomotor behavior trait (VT:0001392)distance moved per unit of time into, out of or within a discrete space in an experimental apparatus (CMO:0001493)4114627026159627026Rat
2293659Bmd35Bone mineral density QTL 354.50.0001femur strength trait (VT:0010010)femoral neck ultimate force (CMO:0001703)4137755016181392681Rat
1331759Hrtrt13Heart rate QTL 133.54628heart pumping trait (VT:2000009)heart rate (CMO:0000002)4110275411168266883Rat
724535Cm18Cardiac mass QTL 182.6heart mass (VT:0007028)calculated heart weight (CMO:0000073)4118856416163856416Rat
2316958Gluco58Glucose level QTL 5810blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)411320076180699135Rat
6478748Anxrr42Anxiety related response QTL 420.28008locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4144639524182687754Rat
12798525Anxrr57Anxiety related response QTL 573.210.05locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4147278504167139601Rat

Markers in Region
D4Wox39  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.04159,079,844 - 159,080,363NCBIRnor6.0
Rnor_5.04226,077,700 - 226,078,219UniSTSRnor5.0
RGSC_v3.44162,898,932 - 162,899,313UniSTSRGSC3.4
Celera4148,074,938 - 148,075,233UniSTS
Cytogenetic Map4q42UniSTS
Kcna5  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24159,356,507 - 159,356,622 (+)MAPPERmRatBN7.2
Rnor_6.04159,078,215 - 159,078,329NCBIRnor6.0
Rnor_5.04226,076,071 - 226,076,185UniSTSRnor5.0
RGSC_v3.44162,897,303 - 162,897,417UniSTSRGSC3.4
Celera4148,073,309 - 148,073,423UniSTS
Cytogenetic Map4q42UniSTS


Genetic Models
This gene Kcna5 is modified in the following models/strains:
SS-Kcna5m1Mcwi    


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 12
Low 31 16 6 3 6 8 11 50 31 25 10 8
Below cutoff 3 30 24 14 24 24 4 14 1

Sequence


Ensembl Acc Id: ENSRNOT00000026691   ⟹   ENSRNOP00000026691
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl4159,350,097 - 159,357,697 (-)Ensembl
Rnor_6.0 Ensembl4159,077,195 - 159,079,003 (-)Ensembl
RefSeq Acc Id: NM_012972   ⟹   NP_037104
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84161,040,853 - 161,043,809 (-)NCBI
mRatBN7.24159,354,703 - 159,357,659 (-)NCBI
Rnor_6.04159,077,195 - 159,079,003 (-)NCBI
Rnor_5.04226,075,051 - 226,076,859 (-)NCBI
RGSC_v3.44162,896,283 - 162,898,091 (-)RGD
Celera4148,072,289 - 148,074,097 (-)RGD
Sequence:
RefSeq Acc Id: XM_039107114   ⟹   XP_038963042
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84161,040,866 - 161,044,311 (-)NCBI
mRatBN7.24159,354,689 - 159,358,173 (-)NCBI
Protein Sequences
Protein RefSeqs NP_037104 (Get FASTA)   NCBI Sequence Viewer  
  XP_038963042 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA41498 (Get FASTA)   NCBI Sequence Viewer  
  AAA42337 (Get FASTA)   NCBI Sequence Viewer  
  EDM01836 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000026691.1
  ENSRNOP00055014535
  ENSRNOP00060022849
  ENSRNOP00065047347
GenBank Protein P19024 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_037104   ⟸   NM_012972
- UniProtKB: Q6LEB7 (UniProtKB/Swiss-Prot),   P19024 (UniProtKB/Swiss-Prot),   A6ILV3 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000026691   ⟸   ENSRNOT00000026691
RefSeq Acc Id: XP_038963042   ⟸   XM_039107114
- Peptide Label: isoform X1
Protein Domains
BTB

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P19024-F1-model_v2 AlphaFold P19024 1-602 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2953 AgrOrtholog
BioCyc Gene G2FUF-42975 BioCyc
Ensembl Genes ENSRNOG00000019719 Ensembl, UniProtKB/Swiss-Prot
  ENSRNOG00055010709 UniProtKB/Swiss-Prot
  ENSRNOG00060016571 UniProtKB/Swiss-Prot
  ENSRNOG00065033450 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000026691.3 UniProtKB/Swiss-Prot
  ENSRNOT00055018093 UniProtKB/Swiss-Prot
  ENSRNOT00060028378 UniProtKB/Swiss-Prot
  ENSRNOT00065057506 UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.287.70 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  1.20.120.350 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro BTB/POZ_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ion_trans_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  K_chnl_volt-dep_Kv UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  K_chnl_volt-dep_Kv1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  K_chnl_volt-dep_Kv1.5 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SKP1/BTB/POZ_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  T1-type_BTB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Volt_channel_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:25470 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 25470 ENTREZGENE
PANTHER POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY A MEMBER 5 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11537 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam BTB_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ion_trans UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB KCNA5 RGD
PhenoGen Kcna5 PhenoGen
PRINTS KCHANNEL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  KV15CHANNEL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  KVCHANNEL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SHAKERCHANEL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000019719 RatGTEx
  ENSRNOG00055010709 RatGTEx
  ENSRNOG00060016571 RatGTEx
  ENSRNOG00065033450 RatGTEx
SMART BTB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP POZ domain UniProtKB/TrEMBL, UniProtKB/Swiss-Prot
  Voltage-gated potassium channels UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC220279
UniProt A6ILV3 ENTREZGENE, UniProtKB/TrEMBL
  KCNA5_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q6LEB7 ENTREZGENE
UniProt Secondary Q6LEB7 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-11 Kcna5  potassium voltage-gated channel subfamily A member 5  Kcna5  potassium channel, voltage gated shaker related subfamily A, member 5  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2015-01-26 Kcna5  potassium channel, voltage gated shaker related subfamily A, member 5  Kcna5  potassium voltage-gated channel, shaker-related subfamily, member 5  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2001-10-23 Kcna5  potassium voltage gated channel, shaker related subfamily, member 5      Name updated 68913 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expression increased in cardiac tissue during development 69868
gene_function voltage-gated potassium channel subunit 628546
gene_pathway induction by Pdgf involves Src family tyrosine kinases, sphingosine kinase and intracellular Ca2+ and phosphatidylinositol 3-kinase pathways 628546
gene_process involved in cell survival,cell cycle progression,membrane excitability and secretory function 628546
gene_process may act on cell cycle progression by affecting membrane potential, cell volume regulation, intracellular calcium levels or Cdk inhibitor levels 628546
gene_regulation expression induced by platelet-derived growth factor (Pdgf) and basic fibroblast growth factor and is accompanied by increased delayed rectifier current (IK),an indicator of mitogenesis 628546