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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2953
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Kcna5
Name: potassium voltage-gated channel subfamily A member 5
Acc ID: CHEBI:64017
Term: (5Z,8Z,11Z,13E)-15-HETE
Definition: A HETE that is (5Z,8Z,11Z,13E)-15-hydroxyicosa-5,8,11,13-tetraenoic acid bearing a hydroxy substituent at position 15.
Chemical ID: MESH:C025984
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Kcna5affects activityEXP 6480464CTD15-hydroxy-5 8 11 13-eicosatetraenoic acid affects the activity of KCNA5 protein

PMID:18984061
Kcna5multiple interactionsEXP 6480464CTD[[Oxygen deficiency results in increased activity of ALOX15 protein] which results in increased chemical synthesis of 15-hydroxy-5 8 11 13-eicosatetraenoic acid] which results in decreased expression of KCNA5 mRNA [[Oxygen deficiency results in increased activity of ALOX15 protein] which results in increased chemical synthesis of 15-hydroxy-5 8 11 13-eicosatetraenoic acid] which results in decreased expression of KCNA5 protein cinnamyl-3 4-dihydroxycyanocinnamate inhibits the reaction [[[Oxygen deficiency results in increased activity of ALOX15 protein] which results in increased chemical synthesis of 15-hydroxy-5 8 11 13-eicosatetraenoic acid] which results in decreased expression of KCNA5 mRNA] Masoprocol inhibits the reaction [[[Oxygen deficiency results in increased activity of ALOX15 protein] which results in increased chemical synthesis of 15-hydroxy-5 8 11 13-eicosatetraenoic acid] which results in decreased expression of KCNA5 mRNA]

PMID:18984061
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