Htr2a (5-hydroxytryptamine receptor 2A) - Rat Genome Database

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Gene: Htr2a (5-hydroxytryptamine receptor 2A) Rattus norvegicus
Analyze
Symbol: Htr2a
Name: 5-hydroxytryptamine receptor 2A
RGD ID: 61800
Description: Predicted to enable several functions, including 1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding activity; Gq/11-coupled serotonin receptor activity; and serotonin binding activity. Involved in several processes, including blood vessel diameter maintenance; detection of stimulus involved in sensory perception of pain; and modulation of chemical synaptic transmission. Located in several cellular components, including cell body fiber; dendritic shaft; and neuronal cell body. Is active in glutamatergic synapse; postsynaptic membrane; and presynaptic membrane. Used to study congestive heart failure; hyperglycemia; and pancreatitis. Biomarker of bladder neck obstruction and schizophrenia. Human ortholog(s) of this gene implicated in several diseases, including alcohol use disorder; anorexia nervosa; major depressive disorder; obesity; and obsessive-compulsive disorder. Orthologous to human HTR2A (5-hydroxytryptamine receptor 2A); PARTICIPATES IN calcium/calcium-mediated signaling pathway; INTERACTS WITH (R,R)-tramadol; (S)-nicotine; 1-bromopropane.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: 5-HT-2; 5-HT-2A; 5-HT2A; 5-hydroxytryptamine (serotonin) receptor 2A; 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled; 5Ht-2; serotonin 5HT-2 receptor; serotonin 5HT-2 receptor gene; serotonin receptor 2A
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21549,950,035 - 50,022,188 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1549,950,804 - 50,020,928 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1554,102,628 - 54,169,818 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01555,214,204 - 55,281,396 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01552,047,008 - 52,120,825 (+)NCBIRnor_WKY
Rnor_6.01556,666,152 - 56,732,469 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1556,666,012 - 56,735,382 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01560,388,557 - 60,454,874 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41555,463,743 - 55,532,293 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11555,479,522 - 55,548,073NCBI
Celera1549,584,210 - 49,652,169 (+)NCBICelera
Cytogenetic Map15q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(R,R)-tramadol  (EXP)
(S)-nicotine  (EXP)
1,2-dichloroethane  (ISO)
1-(3-chlorophenyl)piperazine  (ISO)
1-bromopropane  (EXP)
17beta-estradiol  (EXP)
17beta-estradiol 3-benzoate  (EXP)
2,2',5,5'-tetrachlorobiphenyl  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,4,6-trinitrobenzenesulfonic acid  (EXP)
2-(4-iodo-2,5-dimethoxyphenyl)-1-methylethylamine  (EXP,ISO)
3,4-methylenedioxymethamphetamine  (EXP,ISO)
3,5,6-trichloro-2-pyridinol  (ISO)
3,5,6-trichloropyridine-2-one  (ISO)
3-\{1-[3-(dimethylamino)propyl]-1H-indol-3-yl\}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione  (EXP)
3-phenoxybenzoic acid  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-sulfonyldiphenol  (ISO)
6-propyl-2-thiouracil  (EXP)
acrylamide  (ISO)
adinazolam  (EXP)
albiflorin  (EXP)
alprenolol  (ISO)
ammonium chloride  (EXP)
amphetamine  (EXP)
aripiprazole  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
Bardoxolone methyl  (ISO)
benzimidazoles  (EXP)
benzo[a]pyrene  (EXP,ISO)
benzo[b]fluoranthene  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP)
bupropion  (EXP)
buspirone  (EXP)
Butylbenzyl phthalate  (ISO)
calcium atom  (EXP)
calcium(0)  (EXP)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chlorpyrifos  (EXP,ISO)
cinchocaine  (EXP)
cisplatin  (ISO)
clozapine  (EXP,ISO)
Clozapine N-oxide  (EXP)
cocaine  (EXP,ISO)
colforsin daropate hydrochloride  (EXP)
corticosterone  (EXP)
corticotropin  (EXP)
cyclosporin A  (EXP)
cyhalothrin  (EXP)
cypermethrin  (EXP)
cyproheptadine  (ISO)
DDE  (ISO)
decabromodiphenyl ether  (EXP)
desipramine  (EXP)
dexamethasone  (EXP)
diazinon  (EXP)
dibenziodolium  (EXP)
dibutyl phthalate  (ISO)
diethyl phthalate  (ISO)
Diisodecyl phthalate  (ISO)
dopamine  (EXP)
fenfluramine  (ISO)
fluoxetine  (EXP,ISO)
fluphenazine  (ISO)
fluvoxamine  (ISO)
gamma-hexachlorocyclohexane  (EXP)
genistein  (ISO)
Goe 6976  (EXP)
GR 127935  (EXP)
haloperidol  (EXP,ISO)
herbicide  (ISO)
hexadecanoic acid  (ISO)
imipramine  (EXP)
ketanserin  (EXP,ISO)
lithium chloride  (ISO)
loxapine  (EXP)
metergoline  (ISO)
methamidophos  (ISO)
methamphetamine  (EXP)
methiothepin  (ISO)
mianserin  (ISO)
monocrotaline  (EXP)
N,N-dimethyltryptamine  (ISO)
N-desmethylclozapine  (EXP,ISO)
N-nitrosodiethylamine  (ISO)
nickel atom  (EXP)
nicotine  (EXP)
nitrates  (EXP)
nitrofen  (EXP)
olanzapine  (EXP,ISO)
paliperidone palmitate  (EXP,ISO)
paracetamol  (EXP)
paraquat  (EXP)
parathion  (EXP)
paroxetine  (ISO)
PCB138  (EXP)
phencyclidine  (EXP)
Phenoxybenzamine  (EXP)
phorbol 12,13-dibutanoate  (EXP)
picloram  (ISO)
piperazines  (EXP)
poly(I:C)  (ISO)
progesterone  (EXP,ISO)
quercetin  (EXP)
quetiapine fumarate  (ISO)
raloxifene  (EXP,ISO)
risperidone  (EXP,ISO)
ritanserin  (EXP,ISO)
rotenone  (EXP)
sarpogrelate  (EXP,ISO)
SB 203580  (EXP)
SB 206553  (EXP)
serotonin  (EXP,ISO)
sertraline  (EXP)
sodium arsenite  (EXP)
spiperone  (ISO)
streptozocin  (EXP)
tamoxifen  (ISO)
tebuconazole  (ISO)
temozolomide  (ISO)
tetrachloromethane  (EXP,ISO)
tramadol  (EXP)
tributylstannane  (ISO)
trichloroethene  (EXP)
tryptamine  (ISO)
valproic acid  (ISO)
vincristine  (EXP)
yohimbine  (ISO)
zalcitabine  (EXP,ISO)
ziprasidone  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activation of phospholipase C activity  (ISO)
aging  (IEP)
artery smooth muscle contraction  (IMP)
behavioral response to cocaine  (IDA)
cell death  (IMP)
chemical synaptic transmission  (IBA)
detection of mechanical stimulus involved in sensory perception of pain  (IMP)
detection of temperature stimulus involved in sensory perception of pain  (IMP)
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger  (IBA)
G protein-coupled serotonin receptor signaling pathway  (ISO)
glycolytic process  (ISO)
intracellular calcium ion homeostasis  (ISO)
memory  (IMP)
negative regulation of potassium ion transport  (IMP)
negative regulation of synaptic transmission, glutamatergic  (IMP)
peptidyl-tyrosine phosphorylation  (ISO)
phosphatidylinositol 3-kinase signaling  (ISO)
phospholipase C-activating G protein-coupled receptor signaling pathway  (IBA)
phospholipase C-activating serotonin receptor signaling pathway  (IDA)
positive regulation of cell population proliferation  (IMP)
positive regulation of cytosolic calcium ion concentration  (IMP)
positive regulation of ERK1 and ERK2 cascade  (ISO)
positive regulation of fat cell differentiation  (ISO)
positive regulation of glycolytic process  (ISO)
positive regulation of kinase activity  (ISO)
positive regulation of MAP kinase activity  (IMP)
positive regulation of peptidyl-tyrosine phosphorylation  (ISO)
positive regulation of phosphatidylinositol biosynthetic process  (ISO)
positive regulation of vasoconstriction  (IMP)
presynaptic modulation of chemical synaptic transmission  (EXP,IDA)
protein localization to cytoskeleton  (ISO)
regulation of dopamine secretion  (IMP)
release of sequestered calcium ion into cytosol  (IBA,ISO)
response to xenobiotic stimulus  (IMP,ISO)
sensory perception of pain  (IMP)
sleep  (IMP)
temperature homeostasis  (IMP)
urinary bladder smooth muscle contraction  (IMP)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Response to novelty, social and self-control behaviors, in rats exposed to neonatal anoxia: modulatory effects of an enriched environment. Adriani W, etal., Psychopharmacology (Berl). 2006 Jan;184(2):155-65. Epub 2005 Dec 16.
2. The genetic association database. Becker KG, etal., Nat Genet. 2004 May;36(5):431-2.
3. Existence of Brain 5-HT1A-5-HT2A Isoreceptor Complexes with Antagonistic Allosteric Receptor-Receptor Interactions Regulating 5-HT1A Receptor Recognition. Borroto-Escuela DO, etal., ACS Omega. 2017 Aug 31;2(8):4779-4789. doi: 10.1021/acsomega.7b00629. Epub 2017 Aug 22.
4. Ecstasy-induced cell death in cortical neuronal cultures is serotonin 2A-receptor-dependent and potentiated under hyperthermia. Capela JP, etal., Neuroscience. 2006;139(3):1069-81. Epub 2006 Feb 28.
5. A region-specific increase in Galphaq and Galpha11 proteins in brains of rats during cocaine withdrawal. Carrasco GA, etal., J Pharmacol Exp Ther. 2003 Dec;307(3):1012-9. Epub 2003 Oct 8.
6. Chronic administration of risperidone in a rat model of schizophrenia: a behavioural, morphological and molecular study. Castellano O, etal., Behav Brain Res. 2013 Apr 1;242:178-90. doi: 10.1016/j.bbr.2012.12.036. Epub 2013 Jan 4.
7. Attenuation of Oxytocin and Serotonin 2A Receptor Signaling through Novel Heteroreceptor Formation. Chruścicka B, etal., ACS Chem Neurosci. 2019 Jul 17;10(7):3225-3240. doi: 10.1021/acschemneuro.8b00665. Epub 2019 May 8.
8. Serotonin inhibits voltage-gated K+ currents in pulmonary artery smooth muscle cells: role of 5-HT2A receptors, caveolin-1, and KV1.5 channel internalization. Cogolludo A, etal., Circ Res. 2006 Apr 14;98(7):931-8. Epub 2006 Mar 9.
9. Anxiolytic effect and memory improvement in rats by antisense oligodeoxynucleotide to 5-hydroxytryptamine-2A precursor protein. Cohen H Depress Anxiety. 2005;22(2):84-93.
10. Cellular and subcellular distribution of the serotonin 5-HT2A receptor in the central nervous system of adult rat. Cornea-Hebert V, etal., J Comp Neurol. 1999 Jun 28;409(2):187-209.
11. Isolation and characterization of the rat 5-hydroxytryptamine type 2 receptor promoter: constitutive and inducible activity in myometrial smooth muscle cells. Du YL, etal., Mol Pharmacol 1994 Jun;45(6):1125-31.
12. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
13. Localization of 5-HT2A, 5-HT3, 5-HT5A and 5-HT7 receptor-like immunoreactivity in the rat cerebellum. Geurts FJ, etal., J Chem Neuroanat 2002 Jun;24(1):65-74.
14. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
15. 5-Hydroxytryptamine (serotonin)2A receptors in rat anterior cingulate cortex mediate the discriminative stimulus properties of d-lysergic acid diethylamide. Gresch PJ, etal., J Pharmacol Exp Ther. 2007 Feb;320(2):662-9. Epub 2006 Oct 31.
16. Sarpogrelate hydrochloride, a 5-HT2A receptor antagonist, attenuates neurogenic pain induced by nucleus pulposus in rats. Hashizume H, etal., Spine. 2007 Feb 1;32(3):315-20.
17. Activation of presynaptic 5-hydroxytryptamine 2A receptors facilitates excitatory synaptic transmission via protein kinase C in the dorsolateral septal nucleus. Hasuo H, etal., J Neurosci. 2002 Sep 1;22(17):7509-17.
18. Elevated Expression of Serotonin 5-HT(2A) Receptors in the Rat Ventral Tegmental Area Enhances Vulnerability to the Behavioral Effects of Cocaine. Herin DV, etal., Front Psychiatry. 2013;4:2. doi: 10.3389/fpsyt.2013.00002.
19. The 5HT2 receptor defines a family of structurally distinct but functionally conserved serotonin receptors. Julius D, etal., Proc Natl Acad Sci U S A 1990 Feb;87(3):928-32.
20. Blockade of serotonin 2A receptor improves glomerular endothelial function in rats with streptozotocin-induced diabetic nephropathy. Kobayashi S, etal., Clin Exp Nephrol. 2008 Apr;12(2):119-25. doi: 10.1007/s10157-007-0011-8. Epub 2008 Jan 5.
21. Persistent insulin-sensitizing effects of sarpogrelate hydrochloride, a serotonin 2A receptor antagonist, in patients with peripheral arterial disease. Kokubu N, etal., Circ J. 2006 Nov;70(11):1451-6.
22. Serotonin 5-hydroxytryptamine 2A receptor-coupled phospholipase C and phospholipase A2 signaling pathways have different receptor reserves. Kurrasch-Orbaugh DM, etal., J Pharmacol Exp Ther 2003 Jan;304(1):229-37.
23. Association study of the 5-HT(2A) receptor gene polymorphism, T102C and essential hypertension. Liolitsa D, etal., J Hum Hypertens. 2001 May;15(5):335-9.
24. The 5-HT2 serotonin receptor gene Htr-2 is tightly linked to Es-10 on mouse chromosome 14. Liu J, etal., Genomics 1991 Sep;11(1):231-4.
25. Type 1 Diabetes-Induced Hyper-Responsiveness to 5-Hydroxytryptamine in Rat Pulmonary Arteries via Oxidative Stress and Induction of Cyclooxygenase-2. Lopez-Lopez JG, etal., J Pharmacol Exp Ther. 2011 Jul;338(1):400-7. Epub 2011 Apr 26.
26. DOI, an agonist of 5-HT2A/2C serotonin receptor, alters the expression of cyclooxygenase-2 in the rat parietal cortex. Mackowiak M, etal., J Physiol Pharmacol 2002 Sep;53(3):395-407.
27. An immunocapture/scintillation proximity analysis of G alpha q/11 activation by native serotonin (5-HT)2A receptors in rat cortex: blockade by clozapine and mirtazapine. Mannoury La Cour C, etal., Synapse. 2009 Feb;63(2):95-105.
28. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
29. Ultrastructural localization of serotonin2A receptors in the middle layers of the rat prelimbic prefrontal cortex. Miner LA, etal., Neuroscience. 2003;116(1):107-17.
30. Effects of the serotonin 5-HT2A/2C receptor agonist DOI and of the selective 5-HT2A or 5-HT2C receptor antagonists EMD 281014 and SB-243213, respectively, on sleep and waking in the rat. Monti JM and Jantos H, Eur J Pharmacol. 2006 Dec 28;553(1-3):163-70. Epub 2006 Sep 23.
31. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
32. The fenfluramine metabolite (+)-norfenfluramine is vasoactive. Ni W, etal., J Pharmacol Exp Ther. 2004 May;309(2):845-52. Epub 2004 Jan 29.
33. Effects of R-102444 and its active metabolite R-96544, selective 5-HT2A receptor antagonists, on experimental acute and chronic pancreatitis: Additional evidence for possible involvement of 5-HT2A receptors in the development of experimental pancreatitis. Ogawa T, etal., Eur J Pharmacol. 2005 Oct 3;521(1-3):156-63. Epub 2005 Sep 22.
34. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
35. Serotonin 5-HT(2A) receptor activation induces 2-arachidonoylglycerol release through a phospholipase c-dependent mechanism. Parrish JC and Nichols DE, J Neurochem. 2006 Nov;99(4):1164-75. Epub 2006 Sep 29.
36. Effects of the 5-HT2A antagonist mirtazapine in rat models of thermoregulation. Pawlyk AC, etal., Brain Res. 2006 Dec 6;1123(1):135-44. Epub 2006 Oct 24.
37. Evidence for the preferential involvement of 5-HT2A serotonin receptors in stress- and drug-induced dopamine release in the rat medial prefrontal cortex. Pehek EA, etal., Neuropsychopharmacology. 2006 Feb;31(2):265-77.
38. Disrupting 5-HT(2A) receptor/PDZ protein interactions reduces hyperalgesia and enhances SSRI efficacy in neuropathic pain. Pichon X, etal., Mol Ther. 2010 Aug;18(8):1462-70. doi: 10.1038/mt.2010.101. Epub 2010 Jun 8.
39. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
40. Structure and functional expression of cloned rat serotonin 5HT-2 receptor. Pritchett DB, etal., EMBO J 1988 Dec 20;7(13):4135-40.
41. Dual serotonergic regulation of ventricular contractile force through 5-HT2A and 5-HT4 receptors induced in the acute failing heart. Qvigstad E, etal., Circ Res. 2005 Aug 5;97(3):268-76. Epub 2005 Jul 7.
42. GOA pipeline RGD automated data pipeline
43. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
44. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
45. Crosstalk between GABAB and mGlu1a receptors reveals new insight into GPCR signal integration. Rives ML, etal., EMBO J. 2009 Aug 5;28(15):2195-208. doi: 10.1038/emboj.2009.177. Epub 2009 Jul 9.
46. Subcellular distribution of 5-hydroxytryptamine2A and N-methyl-D-aspartate receptors within single neurons in rat motor and limbic striatum. Rodriguez JJ, etal., J Comp Neurol. 1999 Oct 18;413(2):219-31.
47. 5-Hydroxytryptamine-induced bladder hyperactivity via the 5-HT2A receptor in partial bladder outlet obstruction in rats. Sakai T, etal., Am J Physiol Renal Physiol. 2013 Apr 1;304(7):F1020-7. doi: 10.1152/ajprenal.00365.2012. Epub 2013 Jan 23.
48. Naftopidil inhibits 5-hydroxytryptamine-induced bladder contraction in rats. Sakai T, etal., Eur J Pharmacol. 2013 Jan 30;700(1-3):194-200. doi: 10.1016/j.ejphar.2012.12.022. Epub 2012 Dec 26.
49. No evidence of association between the serotonin 2A receptor--1438G/A promoter polymorphism and childhood obesity in a Spanish population: A case-parent study and a matched case-control study. Santos JL, etal., Nutr Neurosci. 2005 Aug;8(4):207-11.
50. Peripheral 5-HT2A receptor antagonism attenuates primary thermal hyperalgesia and secondary mechanical allodynia after thermal injury in rats. Sasaki M, etal., Pain. 2006 May;122(1-2):130-6. Epub 2006 Mar 9.
51. Age-related changes in the serotonin 2A receptor in the hypoglossal nucleus of male and female rats. Seebart BR, etal., Respir Physiol Neurobiol. 2007 Feb 14;.
52. Effects of peripheral administration of 5-hydroxytryptamine (5-HT ) on 2-deoxy-D-glucose-induced hyperphagia in rats. Sugimoto Y, etal., Biol Pharm Bull. 2002 Oct;25(10):1364-6.
53. The -1438A/G polymorphism in the 5-hydroxytryptamine receptor 2A gene is related to hyperuricemia, increased gamma-glutamyl transpeptidase and decreased high-density lipoprotein cholesterol level in the Japanese population: a prospective cohort study over 5 years. Suwazono Y, etal., Int J Mol Med. 2006 Jan;17(1):77-82.
54. Sarpogrelate hydrochloride, a serotonin2A receptor antagonist, reduces albuminuria in diabetic patients with early-stage diabetic nephropathy. Takahashi T, etal., Diabetes Res Clin Pract. 2002 Nov;58(2):123-9.
55. Selective heterologous regulation of 5-HT1A receptor-stimulated 35S GTPgammaS binding in the anterior cingulate cortex as a result of 5-HT2 receptor activation. Valdez M, etal., Brain Res 2002 Dec 6;957(1):174-82.
56. Unexpected inhibitory regulation of glutamate release from rat cerebrocortical nerve terminals by presynaptic 5-hydroxytryptamine-2A receptors. Wang SJ, etal., J Neurosci Res. 2006 Nov 15;84(7):1528-42.
57. A search for colocalization of serotonin 5-HT2A and 5-HT1A receptors in the rat medial prefrontal and entorhinal cortices--immunohistochemical studies. Wedzony K, etal., J Physiol Pharmacol. 2008 Jun;59(2):229-38.
58. Proliferation and signaling in fibroblasts: role of 5-hydroxytryptamine2A receptor and transporter. Welsh DJ, etal., Am J Respir Crit Care Med. 2004 Aug 1;170(3):252-9. Epub 2004 Apr 15.
59. Serotonin 5-HT2A and 5-HT5A receptors are expressed by different motoneuron populations in rat Onuf's nucleus. Xu C, etal., J Comp Neurol. 2007 Jun 1;502(4):620-34.
60. Hyperglycemia induced by the 5-HT receptor agonist, 5-methoxytryptamine, in rats: involvement of the peripheral 5-HT2A receptor. Yamada J, etal., Eur J Pharmacol. 1997 Apr 4;323(2-3):235-40.
61. T102C genetic polymorphism of the 5-HT2A receptor in Chinese hypertensive patients and healthy controls. Yu BN, etal., Clin Exp Pharmacol Physiol. 2004 Dec;31(12):847-9.
Additional References at PubMed
PMID:7582481   PMID:12058363   PMID:12237191   PMID:12388782   PMID:12670306   PMID:12682061   PMID:12732339   PMID:12753068   PMID:12842309   PMID:14499437   PMID:14499940   PMID:14643760  
PMID:14689478   PMID:15019576   PMID:15065122   PMID:15115744   PMID:15126129   PMID:15129779   PMID:15190056   PMID:15378508   PMID:15664703   PMID:15695159   PMID:15831837   PMID:15862800  
PMID:15882780   PMID:15970592   PMID:16051396   PMID:16203096   PMID:16360124   PMID:16517693   PMID:16707714   PMID:16737974   PMID:16763082   PMID:16871540   PMID:16901936   PMID:17098333  
PMID:17331657   PMID:17395633   PMID:17398000   PMID:17408640   PMID:17412795   PMID:17562393   PMID:17588622   PMID:17600544   PMID:17617403   PMID:17711618   PMID:17720578   PMID:17726509  
PMID:17888573   PMID:17936780   PMID:18046307   PMID:18155835   PMID:18183075   PMID:18187923   PMID:18403899   PMID:18417104   PMID:18420721   PMID:18425575   PMID:18439999   PMID:18442977  
PMID:18604238   PMID:18703043   PMID:18718516   PMID:18772320   PMID:18801389   PMID:18930597   PMID:19057895   PMID:19167402   PMID:19212317   PMID:19269287   PMID:19279328   PMID:19362128  
PMID:19368306   PMID:19500571   PMID:19556691   PMID:19615378   PMID:19772899   PMID:19879056   PMID:19889983   PMID:19937319   PMID:20085755   PMID:20147548   PMID:20471502   PMID:20662937  
PMID:20719859   PMID:20811878   PMID:20857344   PMID:20861436   PMID:20868513   PMID:21126512   PMID:21186576   PMID:21211552   PMID:21245988   PMID:21276431   PMID:21420940   PMID:21598629  
PMID:21600121   PMID:21683764   PMID:21789169   PMID:22056918   PMID:22106156   PMID:22659115   PMID:22791651   PMID:22871113   PMID:22952915   PMID:23201361   PMID:23248270   PMID:23301505  
PMID:23362947   PMID:23399761   PMID:23592773   PMID:23684573   PMID:23721787   PMID:23787365   PMID:23864045   PMID:24058620   PMID:24287377   PMID:24823545   PMID:24888825   PMID:24949809  
PMID:24997405   PMID:25155310   PMID:25185755   PMID:25584948   PMID:25818050   PMID:26031442   PMID:26051401   PMID:26106048   PMID:26120876   PMID:26371055   PMID:26670377   PMID:26769798  
PMID:27109474   PMID:28258217   PMID:28711602   PMID:28750135   PMID:28795477   PMID:30355630   PMID:30523733   PMID:30645940   PMID:31706992   PMID:32425760   PMID:32504811   PMID:32519137  
PMID:34199392  


Genomics

Comparative Map Data
Htr2a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21549,950,035 - 50,022,188 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1549,950,804 - 50,020,928 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1554,102,628 - 54,169,818 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01555,214,204 - 55,281,396 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01552,047,008 - 52,120,825 (+)NCBIRnor_WKY
Rnor_6.01556,666,152 - 56,732,469 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1556,666,012 - 56,735,382 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01560,388,557 - 60,454,874 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41555,463,743 - 55,532,293 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11555,479,522 - 55,548,073NCBI
Celera1549,584,210 - 49,652,169 (+)NCBICelera
Cytogenetic Map15q11NCBI
HTR2A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381346,831,546 - 46,898,082 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1346,831,546 - 46,897,076 (-)EnsemblGRCh38hg38GRCh38
GRCh371347,405,681 - 47,472,217 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361346,305,514 - 46,368,176 (-)NCBINCBI36Build 36hg18NCBI36
Build 341346,305,513 - 46,368,176NCBI
Celera1328,463,441 - 28,527,123 (-)NCBICelera
Cytogenetic Map13q14.2NCBI
HuRef1328,199,237 - 28,264,796 (-)NCBIHuRef
CHM1_11347,373,460 - 47,438,997 (-)NCBICHM1_1
T2T-CHM13v2.01346,052,771 - 46,119,333 (-)NCBIT2T-CHM13v2.0
Htr2a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391474,878,314 - 74,944,299 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1474,878,280 - 74,946,934 (+)EnsemblGRCm39 Ensembl
GRCm381474,640,874 - 74,706,859 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1474,640,840 - 74,709,494 (+)EnsemblGRCm38mm10GRCm38
MGSCv371475,040,647 - 75,106,666 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361473,374,995 - 73,441,014 (+)NCBIMGSCv36mm8
Celera1472,148,249 - 72,214,245 (+)NCBICelera
Cytogenetic Map14D3NCBI
cM Map1439.37NCBI
Htr2a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955431580,713 - 647,345 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955431583,165 - 646,991 (-)NCBIChiLan1.0ChiLan1.0
HTR2A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11346,694,273 - 46,759,826 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1346,694,273 - 46,759,826 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01327,976,415 - 28,042,941 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
HTR2A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1224,453,715 - 4,510,934 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl224,453,715 - 4,511,037 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha224,498,607 - 4,555,448 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0224,566,315 - 4,626,240 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl224,565,931 - 4,625,623 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1224,348,779 - 4,405,847 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0224,412,667 - 4,469,478 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0224,417,008 - 4,474,072 (+)NCBIUU_Cfam_GSD_1.0
Htr2a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404945156,850,452 - 156,910,669 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936565334,393 - 394,715 (-)EnsemblSpeTri2.0
SpeTri2.0NW_004936565335,238 - 394,683 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HTR2A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1120,555,963 - 20,619,625 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11120,555,939 - 20,620,225 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21120,895,106 - 20,956,369 (+)NCBISscrofa10.2Sscrofa10.2susScr3
HTR2A
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1324,820,029 - 24,884,472 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl324,820,035 - 24,883,432 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605719,114,044 - 19,177,668 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Htr2a
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247488,155,107 - 8,223,259 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247488,154,288 - 8,223,226 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Htr2a
514 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:183
Count of miRNA genes:121
Interacting mature miRNAs:153
Transcripts:ENSRNOT00000013408
Prediction methods:Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2298549Neuinf12Neuroinflammation QTL 123.5nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)15155302115Rat
1582251Gluco24Glucose level QTL 243.20.0008blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)15553075650530756Rat
631273Lecl2Lens clarity QTL 20.001lens clarity trait (VT:0001304)age of onset/diagnosis of cataract (CMO:0001584)151059608955596089Rat
2300167Bmd63Bone mineral density QTL 635.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)151111114256111142Rat
2300173Bmd62Bone mineral density QTL 6212.80.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)151111114256111142Rat
2293688Bss29Bone structure and strength QTL 295.310.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)151111114256111142Rat
2317750Glom26Glomerulus QTL 264.3urine protein amount (VT:0005160)urine protein level (CMO:0000591)151249614165205939Rat
61424Scl1Serum cholesterol level QTL 17.70.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)151672552880672115Rat
1331729Rf42Renal function QTL 423.071kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)151736289773690657Rat
10054130Srcrt8Stress Responsive Cort QTL 82.180.0085blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)152211793367117933Rat
1578646Bmd18Bone mineral density QTL 185.2femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)152280624098288169Rat
1578647Bmd17Bone mineral density QTL 174femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)152280624098288169Rat
1578660Bss19Bone structure and strength QTL 194.3femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)152280624098288169Rat
1582214Stl21Serum triglyceride level QTL 213.10.022blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)152803066582262678Rat
1582227Gluco30Glucose level QTL 303.60.0003blood glucose amount (VT:0000188)absolute change in blood glucose level area under curve (CMO:0002034)152803066582262678Rat
1582228Epfw3Epididymal fat weight QTL 34.10.0002epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)152803066582262678Rat
1582242Gluco28Glucose level QTL 283.30.0008blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)152803066582262678Rat
1582244Bw79Body weight QTL 7940.0002epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)152803066582262678Rat
2293691Bmd37Bone mineral density QTL 376.60.0001femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)153361105871477291Rat
2293686Bmd36Bone mineral density QTL 367.40.0001femur strength trait (VT:0010010)femoral neck ultimate force (CMO:0001703)153361105871477291Rat
1598828Glom14Glomerulus QTL 142.5kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)153405413979054139Rat
1300144Rf23Renal function QTL 233.61renal blood flow trait (VT:2000006)absolute change in renal vascular resistance (CMO:0001900)154063126898288169Rat

Markers in Region
Htr2a  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21550,018,770 - 50,018,969 (+)MAPPERmRatBN7.2
Rnor_6.01556,731,983 - 56,732,181NCBIRnor6.0
Rnor_5.01560,454,388 - 60,454,586UniSTSRnor5.0
RGSC_v3.41555,531,807 - 55,532,005UniSTSRGSC3.4
Celera1549,651,683 - 49,651,881UniSTS
Cytogenetic Map15q11UniSTS
G45129  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21549,958,428 - 49,958,664 (+)MAPPERmRatBN7.2
Rnor_6.01556,673,382 - 56,673,617NCBIRnor6.0
Rnor_5.01560,395,787 - 60,396,022UniSTSRnor5.0
RGSC_v3.41555,470,973 - 55,471,208UniSTSRGSC3.4
Celera1549,591,440 - 49,591,675UniSTS
Cytogenetic Map15q11UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 19
Low 26 22 14 14 14 45 29 27 7
Below cutoff 2 17 25 17 5 17 8 10 10 5 10 4 8

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000013408   ⟹   ENSRNOP00000013408
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1549,950,804 - 50,020,928 (+)Ensembl
Rnor_6.0 Ensembl1556,666,012 - 56,735,382 (+)Ensembl
RefSeq Acc Id: NM_017254   ⟹   NP_058950
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21549,951,196 - 50,019,257 (+)NCBI
Rnor_6.01556,666,152 - 56,732,469 (+)NCBI
Rnor_5.01560,388,557 - 60,454,874 (+)NCBI
RGSC_v3.41555,463,743 - 55,532,293 (+)RGD
Celera1549,584,210 - 49,652,169 (+)RGD
Sequence:
RefSeq Acc Id: XM_039093220   ⟹   XP_038949148
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21549,950,055 - 50,022,188 (+)NCBI
RefSeq Acc Id: XM_039093221   ⟹   XP_038949149
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21549,950,035 - 50,022,188 (+)NCBI
Reference Sequences
RefSeq Acc Id: NP_058950   ⟸   NM_017254
- UniProtKB: P14842 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000013408   ⟸   ENSRNOT00000013408
RefSeq Acc Id: XP_038949149   ⟸   XM_039093221
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038949148   ⟸   XM_039093220
- Peptide Label: isoform X1
- UniProtKB: P14842 (UniProtKB/Swiss-Prot)

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P14842-F1-model_v2 AlphaFold P14842 1-471 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:61800 AgrOrtholog
BioCyc Gene G2FUF-13145 BioCyc
Ensembl Genes ENSRNOG00000010063 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSRNOP00000013408 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000013408 ENTREZGENE, UniProtKB/Swiss-Prot
InterPro 5HT2A_rcpt UniProtKB/Swiss-Prot
  5HT_rcpt UniProtKB/Swiss-Prot
  GPCR_Rhodpsn UniProtKB/Swiss-Prot
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot
KEGG Report rno:29595 UniProtKB/Swiss-Prot
NCBI Gene 29595 ENTREZGENE
PANTHER PTHR24247:SF30 UniProtKB/Swiss-Prot
Pfam 7tm_1 UniProtKB/Swiss-Prot
PharmGKB HTR2A RGD
PhenoGen Htr2a PhenoGen
PRINTS 5HT2ARECEPTR UniProtKB/Swiss-Prot
  5HTRECEPTOR UniProtKB/Swiss-Prot
  GPCRRHODOPSN UniProtKB/Swiss-Prot
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/Swiss-Prot
  G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot
SMART 7TM_GPCR_Srsx UniProtKB/Swiss-Prot
UniProt 5HT2A_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-11 Htr2a  5-hydroxytryptamine receptor 2A  Htr2a  5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2012-07-17 Htr2a  5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled  Htr2a  5-hydroxytryptamine (serotonin) receptor 2A  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-02-10 Htr2a  5-hydroxytryptamine (serotonin) receptor 2A  5Ht-2  serotonin 5HT-2 receptor gene  Data Merged 625702 APPROVED
2002-08-07 5Ht-2  serotonin 5HT-2 receptor gene      Symbol and Name status set to provisional 70820 PROVISIONAL
2002-06-10 Htr2a  5-hydroxytryptamine (serotonin) receptor 2A      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in brain and myometrial smooth muscle cells 632275
gene_expression expressed in brain and myometrial smooth muscle cells 632276
gene_pathway activates phospholipase C signaling pathway 728941
gene_process involved in promoting cellular transformation 728941
gene_protein showed high-affinity binding of the serotonin antagonists 632275
gene_regulation transcription induced by 5-HT (serotonin) 632276
gene_transcript upstream of the start site has neither classical TATA boxes nor CCAAT sequences, but contains an initiator consensus sequence, two GC boxes (SP-1 binding sites), and several AP-2 binding sites 632276