Htr2a (5-hydroxytryptamine receptor 2A) - Rat Genome Database

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Gene: Htr2a (5-hydroxytryptamine receptor 2A) Rattus norvegicus
Symbol: Htr2a
Name: 5-hydroxytryptamine receptor 2A
RGD ID: 61800
Description: Predicted to enable several functions, including 1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding activity; Gq/11-coupled serotonin receptor activity; and serotonin binding activity. Involved in several processes, including blood vessel diameter maintenance; detection of stimulus involved in sensory perception of pain; and learning or memory. Located in several cellular components, including cell body fiber; dendritic shaft; and neuronal cell body. Is active in glutamatergic synapse; postsynaptic membrane; and presynaptic membrane. Colocalizes with neurofilament. Used to study several diseases, including alcohol dependence; alcohol use disorder; cocaine abuse; cocaine dependence; and nicotine dependence. Biomarker of several diseases, including alcohol dependence; alcohol use disorder; bladder neck obstruction; cocaine abuse; and congenital diaphragmatic hernia. Human ortholog(s) of this gene implicated in several diseases, including alcohol dependence; alcoholic psychosis; anorexia nervosa; cocaine dependence; and nicotine dependence. Orthologous to human HTR2A (5-hydroxytryptamine receptor 2A); PARTICIPATES IN calcium/calcium-mediated signaling pathway; INTERACTS WITH (R,R)-tramadol; (S)-nicotine; 1-bromopropane.
Type: protein-coding
Previously known as: 5-HT-2; 5-HT-2A; 5-HT2A; 5-hydroxytryptamine (serotonin) receptor 2A; 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled; 5Ht-2; serotonin 5HT-2 receptor; serotonin 5HT-2 receptor gene; serotonin receptor 2A
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.21549,950,035 - 50,022,188 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1549,950,804 - 50,020,928 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1554,102,628 - 54,169,818 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01555,214,204 - 55,281,396 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01552,047,008 - 52,120,825 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01556,666,152 - 56,732,469 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1556,666,012 - 56,735,382 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01560,388,557 - 60,454,874 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41555,463,743 - 55,532,293 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11555,479,522 - 55,548,073NCBI
Celera1549,584,210 - 49,652,169 (+)NCBICelera
Cytogenetic Map15q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations     Click to see Annotation Detail View
Acute Stress Disorders, Traumatic  (IMP)
alcohol dependence  (IEP,IMP,ISO)
alcohol use disorder  (IEP,IMP,ISO)
alcoholic psychosis  (ISO)
Alzheimer's disease  (IDA)
anorexia nervosa  (ISO)
asthma  (ISO)
autistic disorder  (ISO)
Back Pain  (IDA)
basal ganglia disease  (ISO)
bipolar disorder  (IEA,ISO)
bladder neck obstruction  (IEP)
Cardiomegaly  (ISO)
chronic obstructive pulmonary disease  (ISO)
cocaine abuse  (IEP,IMP)
cocaine dependence  (IMP,ISO)
Cocaine-Related Disorders  (ISO)
cognitive disorder  (ISO)
congenital diaphragmatic hernia  (IEP)
congestive heart failure  (IDA)
depressive disorder  (IDA,IEA,IEP)
Diabetic Nephropathies  (IMP,ISO)
disease of metabolism  (ISO)
Dyskinesias  (ISO)
endotoxin shock  (IMP)
Experimental Diabetes Mellitus  (IEP)
Fever  (ISO)
genetic disease  (ISO)
Hallucinations  (ISO)
Hyperalgesia  (IDA,IMP,ISO)
hyperglycemia  (IDA)
Hyperkinesis  (ISO)
Hyperphagia  (IDA)
hypertension  (ISO)
Hypoxia  (IEP)
inflammatory and toxic neuropathy  (IMP)
Insulin Resistance  (ISO)
Intervertebral Disc Displacement  (IEP)
major depressive disorder  (ISO)
Memory Disorders  (ISO)
metabolic dysfunction-associated steatotic liver disease  (ISO)
migraine  (ISO)
morphine dependence  (ISO)
nicotine dependence  (IMP,ISO)
non-alcoholic fatty liver  (ISO)
obesity  (ISO)
obsessive-compulsive disorder  (ISO)
opioid abuse  (ISO)
pancreatitis  (IDA)
pathological gambling  (ISO)
psychotic disorder  (ISO)
schizophrenia  (IDA,IEA,IEP,ISO)
Sleep Bruxism  (ISO)
Sleep Initiation and Maintenance Disorders  (IMP)
steatotic liver disease  (ISO)
stress-related disorder  (IEP)
Urinary Incontinence  (ISO)
Urination Disorders  (IDA)
withdrawal disorder  (IEP,IMP,ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(R,R)-tramadol  (EXP)
(S)-nicotine  (EXP)
1,2-dichloroethane  (ISO)
1-(3-chlorophenyl)piperazine  (ISO)
1-bromopropane  (EXP)
17beta-estradiol  (EXP)
17beta-estradiol 3-benzoate  (EXP)
2,2',5,5'-tetrachlorobiphenyl  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,4,6-trinitrobenzenesulfonic acid  (EXP)
2-(4-iodo-2,5-dimethoxyphenyl)-1-methylethylamine  (EXP,ISO)
3,4-methylenedioxymethamphetamine  (EXP,ISO)
3,5,6-trichloro-2-pyridinol  (ISO)
3,5,6-trichloropyridine-2-one  (ISO)
3-\{1-[3-(dimethylamino)propyl]-1H-indol-3-yl\}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione  (EXP)
3-phenoxybenzoic acid  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-sulfonyldiphenol  (EXP,ISO)
6-propyl-2-thiouracil  (EXP)
acrylamide  (ISO)
adinazolam  (EXP)
albiflorin  (EXP)
alprenolol  (ISO)
ammonium chloride  (EXP)
amphetamine  (EXP)
aripiprazole  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
Bardoxolone methyl  (ISO)
benzimidazoles  (EXP)
benzo[a]pyrene  (EXP,ISO)
benzo[b]fluoranthene  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP)
bupropion  (EXP)
buspirone  (EXP)
Butylbenzyl phthalate  (ISO)
calcium atom  (EXP)
calcium(0)  (EXP)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chlorpyrifos  (EXP,ISO)
cinchocaine  (EXP)
cisplatin  (ISO)
clozapine  (EXP,ISO)
Clozapine N-oxide  (EXP)
cocaine  (EXP,ISO)
colforsin daropate hydrochloride  (EXP)
corticosterone  (EXP)
corticotropin  (EXP)
cyclosporin A  (EXP)
cyhalothrin  (EXP)
cypermethrin  (EXP)
cyproheptadine  (ISO)
decabromodiphenyl ether  (EXP)
desipramine  (EXP)
dexamethasone  (EXP)
diazinon  (EXP)
dibenziodolium  (EXP)
dibutyl phthalate  (ISO)
diethyl phthalate  (ISO)
Diisodecyl phthalate  (ISO)
dopamine  (EXP)
fenfluramine  (ISO)
fluoxetine  (EXP,ISO)
fluphenazine  (ISO)
fluvoxamine  (ISO)
gamma-hexachlorocyclohexane  (EXP)
genistein  (ISO)
Goe 6976  (EXP)
GR 127935  (EXP)
haloperidol  (EXP,ISO)
herbicide  (ISO)
hexadecanoic acid  (ISO)
imipramine  (EXP)
ketanserin  (EXP,ISO)
lithium chloride  (ISO)
loxapine  (EXP)
metergoline  (ISO)
metformin  (EXP)
methamidophos  (ISO)
methamphetamine  (EXP)
methiothepin  (ISO)
mianserin  (ISO)
monocrotaline  (EXP)
N,N-dimethyltryptamine  (ISO)
N-desmethylclozapine  (EXP,ISO)
N-nitrosodiethylamine  (ISO)
nickel atom  (EXP)
nicotine  (EXP)
nitrates  (EXP)
nitrofen  (EXP)
olanzapine  (EXP,ISO)
paliperidone palmitate  (EXP,ISO)
paracetamol  (EXP)
paraquat  (EXP)
parathion  (EXP)
paroxetine  (ISO)
PCB138  (EXP)
phencyclidine  (EXP)
Phenoxybenzamine  (EXP)
phorbol 12,13-dibutanoate  (EXP)
picloram  (ISO)
piperazines  (EXP)
poly(I:C)  (ISO)
progesterone  (EXP,ISO)
quercetin  (EXP)
quetiapine fumarate  (ISO)
raloxifene  (EXP,ISO)
risperidone  (EXP,ISO)
ritanserin  (EXP,ISO)
rotenone  (EXP)
sarpogrelate  (EXP,ISO)
SB 203580  (EXP)
SB 206553  (EXP)
serotonin  (EXP,ISO)
sertraline  (EXP)
sodium arsenite  (EXP)
spiperone  (ISO)
streptozocin  (EXP)
tamoxifen  (ISO)
tebuconazole  (ISO)
temozolomide  (ISO)
tetrachloromethane  (EXP,ISO)
tramadol  (EXP)
tributylstannane  (ISO)
trichloroethene  (EXP)
tryptamine  (ISO)
valproic acid  (ISO)
vincristine  (EXP)
yohimbine  (ISO)
zalcitabine  (EXP,ISO)
ziprasidone  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
artery smooth muscle contraction  (IMP)
behavioral response to cocaine  (IDA)
chemical synaptic transmission  (IBA)
detection of mechanical stimulus involved in sensory perception of pain  (IMP)
detection of temperature stimulus involved in sensory perception of pain  (IMP)
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger  (IBA)
G protein-coupled serotonin receptor signaling pathway  (ISO)
glycolytic process  (ISO)
intracellular calcium ion homeostasis  (ISO)
memory  (IMP)
negative regulation of potassium ion transport  (IMP)
negative regulation of synaptic transmission, glutamatergic  (IMP)
phosphatidylinositol 3-kinase/protein kinase B signal transduction  (ISO)
phospholipase C-activating G protein-coupled receptor signaling pathway  (IBA)
phospholipase C-activating serotonin receptor signaling pathway  (IDA)
positive regulation of cell population proliferation  (IMP)
positive regulation of cytokine production involved in immune response  (IMP)
positive regulation of cytosolic calcium ion concentration  (IDA,IMP)
positive regulation of DNA biosynthetic process  (IMP)
positive regulation of ERK1 and ERK2 cascade  (IMP,ISO)
positive regulation of execution phase of apoptosis  (IDA)
positive regulation of fat cell differentiation  (ISO)
positive regulation of glycolytic process  (ISO)
positive regulation of heat generation  (IMP)
positive regulation of inflammatory response  (IMP)
positive regulation of MAP kinase activity  (IMP)
positive regulation of neuron apoptotic process  (IMP)
positive regulation of peptidyl-tyrosine phosphorylation  (ISO)
positive regulation of phosphatidylinositol biosynthetic process  (ISO)
positive regulation of platelet aggregation  (IMP)
positive regulation of vasoconstriction  (IMP)
presynaptic modulation of chemical synaptic transmission  (EXP,IDA)
protein localization to cytoskeleton  (ISO)
regulation of dopamine secretion  (IMP)
release of sequestered calcium ion into cytosol  (IBA,ISO)
response to cocaine  (IEP)
response to xenobiotic stimulus  (IMP,ISO)
sensitization  (IEP,IMP)
sensory perception of temperature stimulus  (IMP)
temperature homeostasis  (IMP)
urinary bladder smooth muscle contraction  (IMP)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View

References - curated
# Reference Title Reference Citation
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2. Prophylactic and therapeutic effects of acute systemic injections of EMD 281014, a selective serotonin 2A receptor antagonist on anxiety induced by predator stress in rats. Adamec R, etal., Eur J Pharmacol. 2004 Nov 3;504(1-2):79-96. doi: 10.1016/j.ejphar.2004.09.017.
3. Anti-thrombotic and vascular effects of AR246686, a novel 5-HT2A receptor antagonist. Adams JW, etal., Eur J Pharmacol. 2008 May 31;586(1-3):234-43. doi: 10.1016/j.ejphar.2007.11.056. Epub 2007 Dec 3.
4. Response to novelty, social and self-control behaviors, in rats exposed to neonatal anoxia: modulatory effects of an enriched environment. Adriani W, etal., Psychopharmacology (Berl). 2006 Jan;184(2):155-65. Epub 2005 Dec 16.
5. The genetic association database. Becker KG, etal., Nat Genet. 2004 May;36(5):431-2.
6. Deregulated Serotonin Pathway in Women with Morbid Obesity and NAFLD. Binetti J, etal., Life (Basel). 2020 Oct 16;10(10):245. doi: 10.3390/life10100245.
7. Existence of Brain 5-HT1A-5-HT2A Isoreceptor Complexes with Antagonistic Allosteric Receptor-Receptor Interactions Regulating 5-HT1A Receptor Recognition. Borroto-Escuela DO, etal., ACS Omega. 2017 Aug 31;2(8):4779-4789. doi: 10.1021/acsomega.7b00629. Epub 2017 Aug 22.
8. Ecstasy-induced cell death in cortical neuronal cultures is serotonin 2A-receptor-dependent and potentiated under hyperthermia. Capela JP, etal., Neuroscience. 2006;139(3):1069-81. Epub 2006 Feb 28.
9. A region-specific increase in Galphaq and Galpha11 proteins in brains of rats during cocaine withdrawal. Carrasco GA, etal., J Pharmacol Exp Ther. 2003 Dec;307(3):1012-9. Epub 2003 Oct 8.
10. Chronic administration of risperidone in a rat model of schizophrenia: a behavioural, morphological and molecular study. Castellano O, etal., Behav Brain Res. 2013 Apr 1;242:178-90. doi: 10.1016/j.bbr.2012.12.036. Epub 2013 Jan 4.
11. Serotonin activates cell survival and apoptotic death responses in cultured epithelial thyroid cells. Cerulo G, etal., Biochimie. 2014 Oct;105:211-5. doi: 10.1016/j.biochi.2014.06.020. Epub 2014 Jul 2.
12. Attenuation of Oxytocin and Serotonin 2A Receptor Signaling through Novel Heteroreceptor Formation. Chruścicka B, etal., ACS Chem Neurosci. 2019 Jul 17;10(7):3225-3240. doi: 10.1021/acschemneuro.8b00665. Epub 2019 May 8.
13. Serotonin inhibits voltage-gated K+ currents in pulmonary artery smooth muscle cells: role of 5-HT2A receptors, caveolin-1, and KV1.5 channel internalization. Cogolludo A, etal., Circ Res. 2006 Apr 14;98(7):931-8. Epub 2006 Mar 9.
14. Anxiolytic effect and memory improvement in rats by antisense oligodeoxynucleotide to 5-hydroxytryptamine-2A precursor protein. Cohen H Depress Anxiety. 2005;22(2):84-93.
15. Cellular and subcellular distribution of the serotonin 5-HT2A receptor in the central nervous system of adult rat. Cornea-Hebert V, etal., J Comp Neurol. 1999 Jun 28;409(2):187-209.
16. Synergism between a serotonin 5-HT2A receptor (5-HT2AR) antagonist and 5-HT2CR agonist suggests new pharmacotherapeutics for cocaine addiction. Cunningham KA, etal., ACS Chem Neurosci. 2013 Jan 16;4(1):110-21. doi: 10.1021/cn300072u. Epub 2012 Aug 11.
17. Phospholipase C, Ca2+, and calmodulin signaling are required for 5-HT2A receptor-mediated transamidation of Rac1 by transglutaminase. Dai Y, etal., Psychopharmacology (Berl). 2011 Feb;213(2-3):403-12. doi: 10.1007/s00213-010-1984-7. Epub 2010 Aug 18.
18. 5-HT2 receptor antagonists given in the acute withdrawal from daily cocaine injections can reverse established sensitization. Davidson C, etal., Eur J Pharmacol. 2002 Oct 25;453(2-3):255-63. doi: 10.1016/s0014-2999(02)02390-7.
19. Effects of chronic morphine and morphine withdrawal on gene expression in rat peripheral blood mononuclear cells. Desjardins S, etal., Neuropharmacology. 2008 Dec;55(8):1347-54. doi: 10.1016/j.neuropharm.2008.08.027. Epub 2008 Aug 30.
20. Effects of chronic ethanol consumption and aging on 5-HT2A receptors and 5-HT reuptake sites. Druse MJ, etal., Alcohol Clin Exp Res. 1997 Oct;21(7):1157-64.
21. Isolation and characterization of the rat 5-hydroxytryptamine type 2 receptor promoter: constitutive and inducible activity in myometrial smooth muscle cells. Du YL, etal., Mol Pharmacol 1994 Jun;45(6):1125-31.
22. Treadmill Exercise Improves Behavioral and Neurobiological Alterations in Restraint-Stressed Rats. Ercan Z, etal., J Mol Neurosci. 2023 Oct;73(9-10):831-842. doi: 10.1007/s12031-023-02159-2. Epub 2023 Oct 4.
23. Autoradiographic analysis of 5-hydroxytryptamine 5-HT2A binding sites in the rat brain after chronic intragastric ethanol treatments. Fedeli A, etal., Res Commun Mol Pathol Pharmacol. 2002;112(1-4):113-27.
24. Association study of 37 genes related to serotonin and dopamine neurotransmission and neurotrophic factors in cocaine dependence. Fernàndez-Castillo N, etal., Genes Brain Behav. 2013 Feb;12(1):39-46. doi: 10.1111/gbb.12013. Epub 2013 Jan 10.
25. Role of serotonin (5-HT)2 receptors in cocaine self-administration and seeking behavior in rats. Filip M, Pharmacol Rep. 2005 Jan-Feb;57(1):35-46.
26. Effects of the 5-HT2C receptor agonist Ro60-0175 and the 5-HT2A receptor antagonist M100907 on nicotine self-administration and reinstatement. Fletcher PJ, etal., Neuropharmacology. 2012 Jun;62(7):2288-98. doi: 10.1016/j.neuropharm.2012.01.023. Epub 2012 Feb 8.
27. Differences in 5-HT2A and mGlu2 Receptor Expression Levels and Repressive Epigenetic Modifications at the 5-HT2A Promoter Region in the Roman Low- (RLA-I) and High- (RHA-I) Avoidance Rat Strains. Fomsgaard L, etal., Mol Neurobiol. 2018 Mar;55(3):1998-2012. doi: 10.1007/s12035-017-0457-y. Epub 2017 Mar 6.
28. Cocaine potentiates multiple 5-HT2A receptor signaling pathways and is associated with decreased phosphorylation of 5-HT2A receptors in vivo. Franklin JM and Carrasco GA, J Mol Neurosci. 2015 Mar;55(3):770-7. doi: 10.1007/s12031-014-0419-z. Epub 2014 Sep 12.
29. [The analysis of serotonin receptor type 2A gene polymorphism in patients of different nationalities with acute alcoholic psychosis]. Galeeva AR, etal., Zh Nevrol Psikhiatr Im S S Korsakova. 2002;102(1):53-5.
30. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
31. Decreased cerebral cortex and liver 5-HT2A receptor gene expression and enhanced ALDH activity in ethanol-treated rats and hepatocyte cultures. George AK, etal., Neurol Res. 2010 Jun;32(5):510-8. doi: 10.1179/174313209X385554.
32. Localization of 5-HT2A, 5-HT3, 5-HT5A and 5-HT7 receptor-like immunoreactivity in the rat cerebellum. Geurts FJ, etal., J Chem Neuroanat 2002 Jun;24(1):65-74.
33. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
34. 5-Hydroxytryptamine (serotonin)2A receptors in rat anterior cingulate cortex mediate the discriminative stimulus properties of d-lysergic acid diethylamide. Gresch PJ, etal., J Pharmacol Exp Ther. 2007 Feb;320(2):662-9. Epub 2006 Oct 31.
35. Sarpogrelate hydrochloride, a 5-HT2A receptor antagonist, attenuates neurogenic pain induced by nucleus pulposus in rats. Hashizume H, etal., Spine. 2007 Feb 1;32(3):315-20.
36. Activation of presynaptic 5-hydroxytryptamine 2A receptors facilitates excitatory synaptic transmission via protein kinase C in the dorsolateral septal nucleus. Hasuo H, etal., J Neurosci. 2002 Sep 1;22(17):7509-17.
37. Elevated Expression of Serotonin 5-HT(2A) Receptors in the Rat Ventral Tegmental Area Enhances Vulnerability to the Behavioral Effects of Cocaine. Herin DV, etal., Front Psychiatry. 2013;4:2. doi: 10.3389/fpsyt.2013.00002.
38. Upregulation of serotonin-receptor-2a and serotonin transporter expression in the pulmonary vasculature of nitrofen-induced congenital diaphragmatic hernia. Hofmann AD, etal., J Pediatr Surg. 2014 Jun;49(6):871-4; discussion 874-5. doi: 10.1016/j.jpedsurg.2014.01.015. Epub 2014 Jan 31.
39. Ovarian hormones ameliorate memory impairment, cholinergic deficit, neuronal apoptosis and astrogliosis in a rat model of Alzheimer's disease. Hu Z, etal., Exp Ther Med. 2016 Jan;11(1):89-97. doi: 10.3892/etm.2015.2868. Epub 2015 Nov 13.
40. The CC genotype in HTR2A T102C polymorphism is associated with behavioral impulsivity in alcohol-dependent patients. Jakubczyk A, etal., J Psychiatr Res. 2012 Jan;46(1):44-9. doi: 10.1016/j.jpsychires.2011.09.001. Epub 2011 Sep 17.
41. The CC genotype in the T102C HTR2A polymorphism predicts relapse in individuals after alcohol treatment. Jakubczyk A, etal., J Psychiatr Res. 2013 Apr;47(4):527-33. doi: 10.1016/j.jpsychires.2012.12.004. Epub 2013 Jan 12.
42. The 5HT2 receptor defines a family of structurally distinct but functionally conserved serotonin receptors. Julius D, etal., Proc Natl Acad Sci U S A 1990 Feb;87(3):928-32.
43. The effect of a 5-HT2A receptor antagonist on pain-related behavior, endogenous 5-hydroxytryptamine production, and the expression 5-HT2A receptors in dorsal root ganglia in a rat lumbar disc herniation model. Kato K, etal., Spine (Phila Pa 1976). 2015 Mar 15;40(6):357-62. doi: 10.1097/BRS.0000000000000769.
44. 5-HT2A receptor antagonists inhibit hepatic stellate cell activation and facilitate apoptosis. Kim DC, etal., Liver Int. 2013 Apr;33(4):535-43. doi: 10.1111/liv.12110. Epub 2013 Jan 31.
45. Effects of maternal ethanol consumption and buspirone treatment on 5-HT1A and 5-HT2A receptors in offspring. Kim JA, etal., Alcohol Clin Exp Res. 1997 Oct;21(7):1169-78.
46. Synthesis and biological evaluation of tyrosine derivatives as peripheral 5HT2A receptor antagonists for nonalcoholic fatty liver disease. Kim M, etal., Eur J Med Chem. 2022 Sep 5;239:114517. doi: 10.1016/j.ejmech.2022.114517. Epub 2022 Jun 15.
47. Effects of imipramine and bupropion on the duration of immobility of ACTH-treated rats in the forced swim test: involvement of the expression of 5-HT2A receptor mRNA. Kitamura Y, etal., Biol Pharm Bull. 2008 Feb;31(2):246-9. doi: 10.1248/bpb.31.246.
48. Blockade of serotonin 2A receptor improves glomerular endothelial function in rats with streptozotocin-induced diabetic nephropathy. Kobayashi S, etal., Clin Exp Nephrol. 2008 Apr;12(2):119-25. doi: 10.1007/s10157-007-0011-8. Epub 2008 Jan 5.
49. Persistent insulin-sensitizing effects of sarpogrelate hydrochloride, a serotonin 2A receptor antagonist, in patients with peripheral arterial disease. Kokubu N, etal., Circ J. 2006 Nov;70(11):1451-6.
50. [Polymorphic Variants of Glutamate Receptor (GRIK5, GRIN2B) and Serotonin Receptor (HTR2A) Genes Are Associated with Chronic Obstructive Pulmonary Disease]. Korytina GF, etal., Mol Biol (Mosk). 2017 Jul-Aug;51(4):603-614. doi: 10.7868/S0026898417040127.
51. Serotonin 5-hydroxytryptamine 2A receptor-coupled phospholipase C and phospholipase A2 signaling pathways have different receptor reserves. Kurrasch-Orbaugh DM, etal., J Pharmacol Exp Ther 2003 Jan;304(1):229-37.
52. Clinical manifestation of alcohol withdrawal symptoms related to genetic polymorphisms of two serotonin receptors and serotonin transporter. Lee YS, etal., Eur Addict Res. 2009;15(1):39-46. doi: 10.1159/000173008. Epub 2008 Dec 2.
53. Association study of the 5-HT(2A) receptor gene polymorphism, T102C and essential hypertension. Liolitsa D, etal., J Hum Hypertens. 2001 May;15(5):335-9.
54. The 5-HT2 serotonin receptor gene Htr-2 is tightly linked to Es-10 on mouse chromosome 14. Liu J, etal., Genomics 1991 Sep;11(1):231-4.
55. Type 1 Diabetes-Induced Hyper-Responsiveness to 5-Hydroxytryptamine in Rat Pulmonary Arteries via Oxidative Stress and Induction of Cyclooxygenase-2. Lopez-Lopez JG, etal., J Pharmacol Exp Ther. 2011 Jul;338(1):400-7. Epub 2011 Apr 26.
56. DOI, an agonist of 5-HT2A/2C serotonin receptor, alters the expression of cyclooxygenase-2 in the rat parietal cortex. Mackowiak M, etal., J Physiol Pharmacol 2002 Sep;53(3):395-407.
57. An immunocapture/scintillation proximity analysis of G alpha q/11 activation by native serotonin (5-HT)2A receptors in rat cortex: blockade by clozapine and mirtazapine. Mannoury La Cour C, etal., Synapse. 2009 Feb;63(2):95-105.
58. Antagonism of 5-hydroxytryptamine(2a) receptors attenuates the behavioral effects of cocaine in rats. McMahon LR and Cunningham KA, J Pharmacol Exp Ther. 2001 Apr;297(1):357-63.
59. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
60. Ultrastructural localization of serotonin2A receptors in the middle layers of the rat prelimbic prefrontal cortex. Miner LA, etal., Neuroscience. 2003;116(1):107-17.
61. Effects of the serotonin 5-HT2A/2C receptor agonist DOI and of the selective 5-HT2A or 5-HT2C receptor antagonists EMD 281014 and SB-243213, respectively, on sleep and waking in the rat. Monti JM and Jantos H, Eur J Pharmacol. 2006 Dec 28;553(1-3):163-70. Epub 2006 Sep 23.
62. Action of the 5-HT2A antagonist amperozide on alcohol-induced poikilothermia in rats. Myers RD and Lankford M, Pharmacol Biochem Behav. 1998 Jan;59(1):91-5. doi: 10.1016/s0091-3057(97)00330-4.
63. Suppression of alcohol preference in high alcohol drinking rats: efficacy of amperozide versus naltrexone. Myers RD and Lankford MF, Neuropsychopharmacology. 1996 Feb;14(2):139-49. doi: 10.1016/0893-133X(95)00081-N.
64. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
65. The fenfluramine metabolite (+)-norfenfluramine is vasoactive. Ni W, etal., J Pharmacol Exp Ther. 2004 May;309(2):845-52. Epub 2004 Jan 29.
66. Acute effects of sarpogrelate, a 5-HT2A receptor antagonist on cytokine production in endotoxin shock model of rats. Nishiyama T, Eur J Pharmacol. 2009 Jul 1;614(1-3):122-7. doi: 10.1016/j.ejphar.2009.03.041. Epub 2009 Mar 24.
67. Effects of R-102444 and its active metabolite R-96544, selective 5-HT2A receptor antagonists, on experimental acute and chronic pancreatitis: Additional evidence for possible involvement of 5-HT2A receptors in the development of experimental pancreatitis. Ogawa T, etal., Eur J Pharmacol. 2005 Oct 3;521(1-3):156-63. Epub 2005 Sep 22.
68. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
69. Blockade of Serotonin 5-HT2A Receptors Suppresses Behavioral Sensitization and Naloxone-Precipitated Withdrawal Symptoms in Morphine-Treated Mice. Pang G, etal., Front Pharmacol. 2016 Dec 26;7:514. doi: 10.3389/fphar.2016.00514. eCollection 2016.
70. Serotonin 5-HT(2A) receptor activation induces 2-arachidonoylglycerol release through a phospholipase c-dependent mechanism. Parrish JC and Nichols DE, J Neurochem. 2006 Nov;99(4):1164-75. Epub 2006 Sep 29.
71. Effects of the 5-HT2A antagonist mirtazapine in rat models of thermoregulation. Pawlyk AC, etal., Brain Res. 2006 Dec 6;1123(1):135-44. Epub 2006 Oct 24.
72. Evidence for the preferential involvement of 5-HT2A serotonin receptors in stress- and drug-induced dopamine release in the rat medial prefrontal cortex. Pehek EA, etal., Neuropsychopharmacology. 2006 Feb;31(2):265-77.
73. Disrupting 5-HT(2A) receptor/PDZ protein interactions reduces hyperalgesia and enhances SSRI efficacy in neuropathic pain. Pichon X, etal., Mol Ther. 2010 Aug;18(8):1462-70. doi: 10.1038/mt.2010.101. Epub 2010 Jun 8.
74. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
75. Structure and functional expression of cloned rat serotonin 5HT-2 receptor. Pritchett DB, etal., EMBO J 1988 Dec 20;7(13):4135-40.
76. Dual serotonergic regulation of ventricular contractile force through 5-HT2A and 5-HT4 receptors induced in the acute failing heart. Qvigstad E, etal., Circ Res. 2005 Aug 5;97(3):268-76. Epub 2005 Jul 7.
77. Study of polymorphic variants of the serotonin 2A receptor gene (5-HT2A) and its possible effects on smoking habits of a population from northeastern Brazil. Ramos Neto ES, etal., Genet Mol Res. 2014 Oct 20;13(4):8268-77. doi: 10.4238/2014.October.20.3.
78. GOA pipeline RGD automated data pipeline
79. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
80. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
81. Comprehensive gene review and curation RGD comprehensive gene curation
82. Crosstalk between GABAB and mGlu1a receptors reveals new insight into GPCR signal integration. Rives ML, etal., EMBO J. 2009 Aug 5;28(15):2195-208. doi: 10.1038/emboj.2009.177. Epub 2009 Jul 9.
83. Effects of amperozide, 8-OH-DPAT, and FG 5974 on operant responding for ethanol. Roberts AJ, etal., Psychopharmacology (Berl). 1998 May;137(1):25-32. doi: 10.1007/s002130050589.
84. Subcellular distribution of 5-hydroxytryptamine2A and N-methyl-D-aspartate receptors within single neurons in rat motor and limbic striatum. Rodriguez JJ, etal., J Comp Neurol. 1999 Oct 18;413(2):219-31.
85. Differential role of serotonergic polymorphisms in alcohol and heroin dependence. Saiz PA, etal., Prog Neuropsychopharmacol Biol Psychiatry. 2009 Jun 15;33(4):695-700. doi: 10.1016/j.pnpbp.2009.03.016. Epub 2009 Mar 26.
86. 5-Hydroxytryptamine-induced bladder hyperactivity via the 5-HT2A receptor in partial bladder outlet obstruction in rats. Sakai T, etal., Am J Physiol Renal Physiol. 2013 Apr 1;304(7):F1020-7. doi: 10.1152/ajprenal.00365.2012. Epub 2013 Jan 23.
87. Naftopidil inhibits 5-hydroxytryptamine-induced bladder contraction in rats. Sakai T, etal., Eur J Pharmacol. 2013 Jan 30;700(1-3):194-200. doi: 10.1016/j.ejphar.2012.12.022. Epub 2012 Dec 26.
88. Effects of acute and repeated treatment with serotonin 5-HT2A receptor agonist hallucinogens on intracranial self-stimulation in rats. Sakloth F, etal., Exp Clin Psychopharmacol. 2019 Jun;27(3):215-226. doi: 10.1037/pha0000253. Epub 2019 Jan 10.
89. No evidence of association between the serotonin 2A receptor--1438G/A promoter polymorphism and childhood obesity in a Spanish population: A case-parent study and a matched case-control study. Santos JL, etal., Nutr Neurosci. 2005 Aug;8(4):207-11.
90. Peripheral 5-HT2A receptor antagonism attenuates primary thermal hyperalgesia and secondary mechanical allodynia after thermal injury in rats. Sasaki M, etal., Pain. 2006 May;122(1-2):130-6. Epub 2006 Mar 9.
91. Is there an association between T102C polymorphism of the serotonin receptor 2A gene and urinary incontinence? Schwanke CH, etal., Braz J Med Biol Res. 2007 Oct;40(10):1315-22. doi: 10.1590/s0100-879x2006005000151. Epub 2007 Jul 31.
92. Age-related changes in the serotonin 2A receptor in the hypoglossal nucleus of male and female rats. Seebart BR, etal., Respir Physiol Neurobiol. 2007 Feb 14;.
93. Effects of peripheral administration of 5-hydroxytryptamine (5-HT ) on 2-deoxy-D-glucose-induced hyperphagia in rats. Sugimoto Y, etal., Biol Pharm Bull. 2002 Oct;25(10):1364-6.
94. Involvement of pro-nociceptive 5-HT2A receptor in the pathogenesis of medication-overuse headache. Supornsilpchai W, etal., Headache. 2010 Feb;50(2):185-97. doi: 10.1111/j.1526-4610.2009.01591.x. Epub 2009 Dec 21.
95. The -1438A/G polymorphism in the 5-hydroxytryptamine receptor 2A gene is related to hyperuricemia, increased gamma-glutamyl transpeptidase and decreased high-density lipoprotein cholesterol level in the Japanese population: a prospective cohort study over 5 years. Suwazono Y, etal., Int J Mol Med. 2006 Jan;17(1):77-82.
96. Sarpogrelate hydrochloride, a serotonin2A receptor antagonist, reduces albuminuria in diabetic patients with early-stage diabetic nephropathy. Takahashi T, etal., Diabetes Res Clin Pract. 2002 Nov;58(2):123-9.
97. Serotonin 5-HT2A receptor involvement and Fos expression at the spinal level in vincristine-induced neuropathy in the rat. Thibault K, etal., Pain. 2008 Nov 30;140(2):305-322. doi: 10.1016/j.pain.2008.09.006. Epub 2008 Oct 18.
98. Serotonin (5-HT)2A/2C receptor agonist (2,5-dimethoxy-4-idophenyl)-2-aminopropane hydrochloride (DOI) improves voiding efficiency in the diabetic rat. Tu H, etal., BJU Int. 2015 Jul;116(1):147-55. doi: 10.1111/bju.12684. Epub 2015 Mar 27.
99. Selective heterologous regulation of 5-HT1A receptor-stimulated 35S GTPgammaS binding in the anterior cingulate cortex as a result of 5-HT2 receptor activation. Valdez M, etal., Brain Res 2002 Dec 6;957(1):174-82.
100. The 5-HT2A receptor is mainly expressed in nociceptive sensory neurons in rat lumbar dorsal root ganglia. Van Steenwinckel J, etal., Neuroscience. 2009 Jul 7;161(3):838-46. doi: 10.1016/j.neuroscience.2009.03.087. Epub 2009 Apr 9.
101. Role of spinal serotonin 5-HT2A receptor in 2',3'-dideoxycytidine-induced neuropathic pain in the rat and the mouse. Van Steenwinckel J, etal., Pain. 2008 Jul;137(1):66-80. doi: 10.1016/j.pain.2007.08.014. Epub 2007 Sep 20.
102. Essential role of TRPC1 channels in cardiomyoblasts hypertrophy mediated by 5-HT2A serotonin receptors. Vindis C, etal., Biochem Biophys Res Commun. 2010 Jan 1;391(1):979-83. doi: 10.1016/j.bbrc.2009.12.001. Epub 2009 Dec 11.
103. Unexpected inhibitory regulation of glutamate release from rat cerebrocortical nerve terminals by presynaptic 5-hydroxytryptamine-2A receptors. Wang SJ, etal., J Neurosci Res. 2006 Nov 15;84(7):1528-42.
104. A search for colocalization of serotonin 5-HT2A and 5-HT1A receptors in the rat medial prefrontal and entorhinal cortices--immunohistochemical studies. Wedzony K, etal., J Physiol Pharmacol. 2008 Jun;59(2):229-38.
105. Proliferation and signaling in fibroblasts: role of 5-hydroxytryptamine2A receptor and transporter. Welsh DJ, etal., Am J Respir Crit Care Med. 2004 Aug 1;170(3):252-9. Epub 2004 Apr 15.
106. Family-based association analysis of serotonin genes in pathological gambling disorder: evidence of vulnerability risk in the 5HT-2A receptor gene. Wilson D, etal., J Mol Neurosci. 2013 Mar;49(3):550-3. doi: 10.1007/s12031-012-9846-x. Epub 2012 Jun 28.
107. Enduring Loss of Serotonergic Control of Orbitofrontal Cortex Function Following Contingent and Noncontingent Cocaine Exposure. Wright AM, etal., Cereb Cortex. 2017 Dec 1;27(12):5463-5476. doi: 10.1093/cercor/bhw312.
108. Synthesis and in vivo evaluation of phenethylpiperazine amides: selective 5-hydroxytryptamine(2A) receptor antagonists for the treatment of insomnia. Xiong Y, etal., J Med Chem. 2010 Aug 12;53(15):5696-706. doi: 10.1021/jm100479q.
109. Serotonin 5-HT2A and 5-HT5A receptors are expressed by different motoneuron populations in rat Onuf's nucleus. Xu C, etal., J Comp Neurol. 2007 Jun 1;502(4):620-34.
110. Hyperglycemia induced by the 5-HT receptor agonist, 5-methoxytryptamine, in rats: involvement of the peripheral 5-HT2A receptor. Yamada J, etal., Eur J Pharmacol. 1997 Apr 4;323(2-3):235-40.
111. T102C genetic polymorphism of the 5-HT2A receptor in Chinese hypertensive patients and healthy controls. Yu BN, etal., Clin Exp Pharmacol Physiol. 2004 Dec;31(12):847-9.
112. Discovering the mechanisms underlying serotonin (5-HT)2A and 5-HT2C receptor regulation following nicotine withdrawal in rats. Zaniewska M, etal., J Neurochem. 2015 Aug;134(4):704-16. doi: 10.1111/jnc.13192. Epub 2015 Jun 26.
113. Context-controlled nicotine-induced changes in the labeling of serotonin (5-HT)2A and 5-HT2C receptors in the rat brain. Zaniewska M, etal., Pharmacol Rep. 2015 Jun;67(3):451-9. doi: 10.1016/j.pharep.2014.11.002. Epub 2014 Nov 24.
114. Blockade of nucleus accumbens 5-HT2A and 5-HT2C receptors prevents the expression of cocaine-induced behavioral and neurochemical sensitization in rats. Zayara AE, etal., Psychopharmacology (Berl). 2011 Feb;213(2-3):321-35. doi: 10.1007/s00213-010-1996-3. Epub 2010 Sep 3.
115. Chronic Oxycodone Self-administration Altered Reward-related Genes in the Ventral and Dorsal Striatum of C57BL/6J Mice: An RNA-seq Analysis. Zhang Y, etal., Neuroscience. 2018 Nov 21;393:333-349. doi: 10.1016/j.neuroscience.2018.07.032. Epub 2018 Jul 29.
Additional References at PubMed
PMID:7582481   PMID:12058363   PMID:12237191   PMID:12388782   PMID:12670306   PMID:12682061   PMID:12732339   PMID:12753068   PMID:12842309   PMID:14499437   PMID:14499940   PMID:14643760  
PMID:14689478   PMID:15019576   PMID:15065122   PMID:15115744   PMID:15126129   PMID:15129779   PMID:15190056   PMID:15378508   PMID:15664703   PMID:15695159   PMID:15831837   PMID:15862800  
PMID:15882780   PMID:15970592   PMID:16051396   PMID:16203096   PMID:16360124   PMID:16517693   PMID:16707714   PMID:16737974   PMID:16763082   PMID:16871540   PMID:16901936   PMID:17098333  
PMID:17331657   PMID:17395633   PMID:17398000   PMID:17408640   PMID:17412795   PMID:17562393   PMID:17588622   PMID:17600544   PMID:17617403   PMID:17711618   PMID:17720578   PMID:17726509  
PMID:17936780   PMID:18046307   PMID:18155835   PMID:18183075   PMID:18187923   PMID:18403899   PMID:18417104   PMID:18420721   PMID:18425575   PMID:18439999   PMID:18442977   PMID:18604238  
PMID:18703043   PMID:18718516   PMID:18772320   PMID:18801389   PMID:19057895   PMID:19167402   PMID:19212317   PMID:19269287   PMID:19279328   PMID:19368306   PMID:19500571   PMID:19556691  
PMID:19615378   PMID:19772899   PMID:19879056   PMID:19889983   PMID:19937319   PMID:20085755   PMID:20147548   PMID:20471502   PMID:20662937   PMID:20719859   PMID:20811878   PMID:20857344  
PMID:20861436   PMID:20868513   PMID:21126512   PMID:21186576   PMID:21211552   PMID:21245988   PMID:21276431   PMID:21420940   PMID:21598629   PMID:21600121   PMID:21683764   PMID:21789169  
PMID:22056918   PMID:22106156   PMID:22659115   PMID:22791651   PMID:22871113   PMID:22952915   PMID:23201361   PMID:23248270   PMID:23301505   PMID:23399761   PMID:23592773   PMID:23684573  
PMID:23721787   PMID:23787365   PMID:23864045   PMID:24058620   PMID:24287377   PMID:24823545   PMID:24949809   PMID:25155310   PMID:25185755   PMID:25818050   PMID:26051401   PMID:26106048  
PMID:26120876   PMID:26371055   PMID:26670377   PMID:26769798   PMID:27109474   PMID:28258217   PMID:28711602   PMID:28750135   PMID:28795477   PMID:30355630   PMID:30523733   PMID:30645940  
PMID:31706992   PMID:32425760   PMID:32504811   PMID:32519137   PMID:34199392   PMID:37523044  


Comparative Map Data
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.21549,950,035 - 50,022,188 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1549,950,804 - 50,020,928 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1554,102,628 - 54,169,818 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01555,214,204 - 55,281,396 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01552,047,008 - 52,120,825 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01556,666,152 - 56,732,469 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1556,666,012 - 56,735,382 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01560,388,557 - 60,454,874 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41555,463,743 - 55,532,293 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11555,479,522 - 55,548,073NCBI
Celera1549,584,210 - 49,652,169 (+)NCBICelera
Cytogenetic Map15q11NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh381346,831,546 - 46,898,082 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1346,831,546 - 46,897,076 (-)EnsemblGRCh38hg38GRCh38
GRCh371347,405,681 - 47,472,217 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361346,305,514 - 46,368,176 (-)NCBINCBI36Build 36hg18NCBI36
Build 341346,305,513 - 46,368,176NCBI
Celera1328,463,441 - 28,527,123 (-)NCBICelera
Cytogenetic Map13q14.2NCBI
HuRef1328,199,237 - 28,264,796 (-)NCBIHuRef
CHM1_11347,373,460 - 47,438,997 (-)NCBICHM1_1
T2T-CHM13v2.01346,052,771 - 46,119,333 (-)NCBIT2T-CHM13v2.0
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm391474,878,314 - 74,944,299 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1474,878,280 - 74,946,934 (+)EnsemblGRCm39 Ensembl
GRCm381474,640,874 - 74,706,859 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1474,640,840 - 74,709,494 (+)EnsemblGRCm38mm10GRCm38
MGSCv371475,040,647 - 75,106,666 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361473,374,995 - 73,441,014 (+)NCBIMGSCv36mm8
Celera1472,148,249 - 72,214,245 (+)NCBICelera
Cytogenetic Map14D3NCBI
cM Map1439.37NCBI
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0 EnsemblNW_004955431580,713 - 647,345 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955431583,165 - 646,991 (-)NCBIChiLan1.0ChiLan1.0
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
NHGRI_mPanPan11346,927,083 - 46,993,610 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01327,976,415 - 28,042,941 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11346,694,273 - 46,759,826 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1346,694,273 - 46,759,826 (-)Ensemblpanpan1.1panPan2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.1224,453,715 - 4,510,934 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl224,453,715 - 4,511,037 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha224,498,607 - 4,555,448 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0224,566,315 - 4,626,240 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl224,565,931 - 4,625,623 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1224,348,779 - 4,405,847 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0224,412,667 - 4,469,478 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0224,417,008 - 4,474,072 (+)NCBIUU_Cfam_GSD_1.0
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2NW_024404945156,850,452 - 156,910,669 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936565334,393 - 394,715 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936565335,238 - 394,683 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl1120,555,963 - 20,619,625 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11120,555,939 - 20,620,225 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21120,895,106 - 20,956,369 (+)NCBISscrofa10.2Sscrofa10.2susScr3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.1324,820,029 - 24,884,472 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl324,820,035 - 24,883,432 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605719,114,044 - 19,177,668 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla_female_1.0 EnsemblNW_0046247488,155,107 - 8,223,259 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247488,154,288 - 8,223,226 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Variants in Htr2a
514 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:183
Count of miRNA genes:121
Interacting mature miRNAs:153
Prediction methods:Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2298549Neuinf12Neuroinflammation QTL 123.5nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)15155302115Rat
1582251Gluco24Glucose level QTL 243.20.0008blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)15553075650530756Rat
631273Lecl2Lens clarity QTL 20.001lens clarity trait (VT:0001304)age of onset/diagnosis of cataract (CMO:0001584)151059608955596089Rat
2300167Bmd63Bone mineral density QTL 635.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)151111114256111142Rat
2300173Bmd62Bone mineral density QTL 6212.80.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)151111114256111142Rat
2293688Bss29Bone structure and strength QTL 295.310.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)151111114256111142Rat
2317750Glom26Glomerulus QTL 264.3urine protein amount (VT:0005160)urine protein level (CMO:0000591)151249614165205939Rat
61424Scl1Serum cholesterol level QTL 17.70.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)151672552880672115Rat
1331729Rf42Renal function QTL 423.071kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)151736289773690657Rat
10054130Srcrt8Stress Responsive Cort QTL 82.180.0085blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)152211793367117933Rat
1578646Bmd18Bone mineral density QTL 185.2femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)152280624098288169Rat
1578647Bmd17Bone mineral density QTL 174femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)152280624098288169Rat
1578660Bss19Bone structure and strength QTL 194.3femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)152280624098288169Rat
1582214Stl21Serum triglyceride level QTL 213.10.022blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)152803066582262678Rat
1582227Gluco30Glucose level QTL 303.60.0003blood glucose amount (VT:0000188)absolute change in blood glucose level area under curve (CMO:0002034)152803066582262678Rat
1582228Epfw3Epididymal fat weight QTL 34.10.0002epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)152803066582262678Rat
1582242Gluco28Glucose level QTL 283.30.0008blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)152803066582262678Rat
1582244Bw79Body weight QTL 7940.0002epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)152803066582262678Rat
2293691Bmd37Bone mineral density QTL 376.60.0001femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)153361105871477291Rat
2293686Bmd36Bone mineral density QTL 367.40.0001femur strength trait (VT:0010010)femoral neck ultimate force (CMO:0001703)153361105871477291Rat
1598828Glom14Glomerulus QTL 142.5kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)153405413979054139Rat
1300144Rf23Renal function QTL 233.61renal blood flow trait (VT:2000006)absolute change in renal vascular resistance (CMO:0001900)154063126898288169Rat

Markers in Region
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21550,018,770 - 50,018,969 (+)MAPPERmRatBN7.2
Rnor_6.01556,731,983 - 56,732,181NCBIRnor6.0
Rnor_5.01560,454,388 - 60,454,586UniSTSRnor5.0
RGSC_v3.41555,531,807 - 55,532,005UniSTSRGSC3.4
Celera1549,651,683 - 49,651,881UniSTS
Cytogenetic Map15q11UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21549,958,428 - 49,958,664 (+)MAPPERmRatBN7.2
Rnor_6.01556,673,382 - 56,673,617NCBIRnor6.0
Rnor_5.01560,395,787 - 60,396,022UniSTSRnor5.0
RGSC_v3.41555,470,973 - 55,471,208UniSTSRGSC3.4
Celera1549,591,440 - 49,591,675UniSTS
Cytogenetic Map15q11UniSTS


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
Medium 19
Low 26 22 14 14 14 45 29 27 7
Below cutoff 2 17 25 17 5 17 8 10 10 5 10 4 8


RefSeq Acc Id: ENSRNOT00000013408   ⟹   ENSRNOP00000013408
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1549,950,804 - 50,020,928 (+)Ensembl
Rnor_6.0 Ensembl1556,666,012 - 56,735,382 (+)Ensembl
RefSeq Acc Id: NM_017254   ⟹   NP_058950
Rat AssemblyChrPosition (strand)Source
mRatBN7.21549,951,196 - 50,019,257 (+)NCBI
Rnor_6.01556,666,152 - 56,732,469 (+)NCBI
Rnor_5.01560,388,557 - 60,454,874 (+)NCBI
RGSC_v3.41555,463,743 - 55,532,293 (+)RGD
Celera1549,584,210 - 49,652,169 (+)RGD
RefSeq Acc Id: XM_039093220   ⟹   XP_038949148
Rat AssemblyChrPosition (strand)Source
mRatBN7.21549,950,055 - 50,022,188 (+)NCBI
RefSeq Acc Id: XM_039093221   ⟹   XP_038949149
Rat AssemblyChrPosition (strand)Source
mRatBN7.21549,950,035 - 50,022,188 (+)NCBI
RefSeq Acc Id: NP_058950   ⟸   NM_017254
- UniProtKB: P14842 (UniProtKB/Swiss-Prot),   A6HTR4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000013408   ⟸   ENSRNOT00000013408
RefSeq Acc Id: XP_038949149   ⟸   XM_039093221
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038949148   ⟸   XM_039093220
- Peptide Label: isoform X1
- UniProtKB: P14842 (UniProtKB/Swiss-Prot),   A6HTR4 (UniProtKB/TrEMBL)
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P14842-F1-model_v2 AlphaFold P14842 1-471 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:61800 AgrOrtholog
BioCyc Gene G2FUF-13145 BioCyc
Ensembl Genes ENSRNOG00000010063 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOG00055014961 UniProtKB/Swiss-Prot
  ENSRNOG00060016970 UniProtKB/Swiss-Prot
  ENSRNOG00065008875 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000013408 ENTREZGENE
  ENSRNOT00000013408.7 UniProtKB/Swiss-Prot
  ENSRNOT00055025574 UniProtKB/Swiss-Prot
  ENSRNOT00060029001 UniProtKB/Swiss-Prot
  ENSRNOT00065014166 UniProtKB/Swiss-Prot
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro 5HT2A_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  5HT_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_Rhodpsn UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:29595 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam 7tm_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Htr2a PhenoGen
  5HTRECEPTOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000010063 RatGTEx
  ENSRNOG00055014961 RatGTEx
  ENSRNOG00060016970 RatGTEx
  ENSRNOG00065008875 RatGTEx
SMART 7TM_GPCR_Srsx UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt 5HT2A_RAT UniProtKB/Swiss-Prot

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-11 Htr2a  5-hydroxytryptamine receptor 2A  Htr2a  5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2012-07-17 Htr2a  5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled  Htr2a  5-hydroxytryptamine (serotonin) receptor 2A  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-02-10 Htr2a  5-hydroxytryptamine (serotonin) receptor 2A  5Ht-2  serotonin 5HT-2 receptor gene  Data merged from RGD:619815 625702 APPROVED
2002-08-07 5Ht-2  serotonin 5HT-2 receptor gene      Symbol and Name status set to provisional 70820 PROVISIONAL
2002-06-10 Htr2a  5-hydroxytryptamine (serotonin) receptor 2A      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in brain and myometrial smooth muscle cells 632275
gene_expression expressed in brain and myometrial smooth muscle cells 632276
gene_pathway activates phospholipase C signaling pathway 728941
gene_process involved in promoting cellular transformation 728941
gene_protein showed high-affinity binding of the serotonin antagonists 632275
gene_regulation transcription induced by 5-HT (serotonin) 632276
gene_transcript upstream of the start site has neither classical TATA boxes nor CCAAT sequences, but contains an initiator consensus sequence, two GC boxes (SP-1 binding sites), and several AP-2 binding sites 632276