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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 61800
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Htr2a
Name: 5-hydroxytryptamine receptor 2A
Acc ID: CHEBI:83807
Term: paliperidone palmitate
Definition: A racemate comprising equimolar amounts of (R)- and (S)-paliperidone palmitate. A long-acting injectable formulation of paliperidone (the major active metabolite of risperidone) that is used for treatment of schizophrenia.
Chemical ID: MESH:D000068882
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Htr2aaffects bindingEXP 6480464CTDPaliperidone Palmitate binds to HTR2A protein

PMID:22437487
Htr2aaffects bindingISORGD:7341076480464CTDPaliperidone Palmitate binds to HTR2A protein

PMID:7520908
Htr2amultiple interactionsISORGD:7341076480464CTDPaliperidone Palmitate binds to and results in decreased activity of HTR2A protein

PMID:19713555
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