Gene: Cav1 (caveolin 1) Rattus norvegicus
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Symbol: Cav1
Name: caveolin 1
Description: ENCODES a protein that exhibits ion channel binding; kinase binding; nitric-oxide synthase binding; INVOLVED IN animal organ regeneration; cellular calcium ion homeostasis; cellular response to mechanical stimulus; PARTICIPATES IN insulin signaling pathway; platelet-derived growth factor signaling pathway; reverse cholesterol transport pathway; ASSOCIATED WITH Acute Lung Injury; Alcoholic Liver Diseases; atherosclerosis; FOUND IN basal plasma membrane; caveola; cell surface; INTERACTS WITH (S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine
AGR Description: Exhibits several functions, including enzyme binding activity, ion channel binding activity, and receptor serine/threonine kinase binding activity; involved in several processes, including negative regulation of cell population proliferation, positive regulation of cellular component organization, and regulation of signal transduction; localizes to several cellular components, including the basal plasma membrane, caveola, and cytoplasm; predicted to colocalize with the VCP-NPL4-UFD1 AAA ATPase complex and sarcolemma; biomarker of several diseases, including artery disease (multiple), brain ischemia (multiple), hypothyroidism, malignant glioma, and obesity; orthologous to human CAV1 (caveolin 1).
Merged Description: Exhibits several functions, including enzyme binding activity, ion channel binding activity, and receptor serine/threonine kinase binding activity; involved in several processes, including negative regulation of cell population proliferation, positive regulation of cellular component organization, and regulation of signal transduction; localizes to several cellular components, including the basal plasma membrane, caveola, and cytoplasm; predicted to colocalize with the VCP-NPL4-UFD1 AAA ATPase complex and sarcolemma; biomarker of several diseases, including artery disease (multiple), brain ischemia (multiple), hypothyroidism, malignant glioma, and obesity; orthologous to human CAV1 (caveolin 1); PARTICIPATES IN insulin signaling pathway; platelet-derived growth factor signaling pathway; reverse cholesterol transport pathway; INTERACTS WITH (S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: Cav; caveolin; caveolin 1, caveolae protein; Caveolin caveolae protein 22 kDa; caveolin, caveolae protein 1; Caveolin, caveolae protein, 22 kDa; caveolin-1; caveolin-like; LOC100362870; MGC187299
Orthologs:
Homo sapiens (human) : CAV1 (caveolin 1)  HGNC  Alliance
Mus musculus (house mouse) : Cav1 (caveolin 1, caveolae protein)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Cav1 (caveolin 1)
Pan paniscus (bonobo/pygmy chimpanzee) : CAV1 (caveolin 1)
Canis lupus familiaris (dog) : CAV1 (caveolin 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Cav1 (caveolin 1)
Sus scrofa (pig) : CAV1 (caveolin 1)
more info ...
Is Marker For: Strains:   BB/OK  
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0444,597,123 - 44,630,206 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0445,203,494 - 45,236,461 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4442,956,102 - 42,989,057 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1443,098,177 - 43,130,873 (+)NCBI
Celera440,918,628 - 40,949,677 (+)NCBICelera
Cytogenetic Map4q21NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated
RGD Disease Portals

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
Related Rat Strains
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 5.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Cav1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 2280
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2019-04-12
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.