Aqp1 (aquaporin 1) - Rat Genome Database

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Gene: Aqp1 (aquaporin 1) Rattus norvegicus
Symbol: Aqp1
Name: aquaporin 1
RGD ID: 2141
Description: Enables glycerol transmembrane transporter activity and water channel activity. Involved in several processes, including glycerol transmembrane transport; lateral ventricle development; and positive regulation of lamellipodium assembly. Located in several cellular components, including basolateral plasma membrane; brush border; and neuronal cell body membrane. Biomarker of several diseases, including autosomal recessive polycystic kidney disease; brain disease (multiple); hypertension; retinal vein occlusion; and uveitis. Orthologous to human AQP1 (aquaporin 1 (Colton blood group)); PARTICIPATES IN amiloride pharmacodynamics pathway; bendroflumethiazide pharmacodynamics pathway; bumetanide pharmacodynamics pathway; INTERACTS WITH 17beta-estradiol; 2,2,2-tetramine; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
Previously known as: AQP-1; Aquaporin 1 (aquaporin channel forming integral protein 28 (CHIP)); aquaporin 1 (Colton blood group); aquaporin-1; aquaporin-CHIP; CHIP28; water channel protein for red blood cells and kidney proximal tubule
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Is Marker For: Strains:   SD  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
GRCr8485,812,784 - 85,824,964 (+)NCBIGRCr8
mRatBN7.2484,482,512 - 84,494,690 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl484,482,512 - 84,494,690 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx489,700,946 - 89,713,083 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0485,476,356 - 85,488,493 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0483,882,115 - 83,894,263 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0485,551,503 - 85,563,683 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl485,551,502 - 85,569,360 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04150,203,461 - 150,215,641 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4484,098,346 - 84,110,524 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1484,384,810 - 84,396,991 (+)NCBI
Celera479,349,727 - 79,361,905 (+)NCBICelera
Cytogenetic Map4q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
(1->4)-beta-D-glucan  (ISO)
(S)-naringenin  (ISO)
1,1-dichloroethene  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,2,2-tetramine  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
2-(3,4-dimethoxyphenyl)-5-\{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino\}-2-(propan-2-yl)pentanenitrile  (ISO)
2-methoxy-17beta-estradiol  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,3',5-triiodo-L-thyronine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
6-propyl-2-thiouracil  (EXP,ISO)
7,12-dimethyltetraphene  (EXP)
7,9-dihydro-1H-purine-2,6,8(3H)-trione  (ISO)
acetazolamide  (ISO)
acrylamide  (ISO)
actinomycin D  (ISO)
adenine  (ISO)
aflatoxin B1  (EXP,ISO)
Aflatoxin B2 alpha  (ISO)
aldehydo-D-glucose  (EXP)
amitrole  (EXP)
ammonium chloride  (EXP)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
atrazine  (EXP,ISO)
benazepril  (EXP)
benzo[a]pyrene  (ISO)
benzo[e]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bleomycin A2  (EXP)
butanal  (ISO)
cadmium dichloride  (EXP)
Calphostin C  (ISO)
cannabidiol  (ISO)
capsaicin  (ISO)
captan  (ISO)
carbon nanotube  (ISO)
chlorogenic acid  (ISO)
chlorpyrifos  (ISO)
ciglitazone  (EXP)
clofibrate  (ISO)
cobalt dichloride  (EXP,ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
corticosterone  (EXP)
Cuprizon  (EXP)
cycloheximide  (ISO)
cyclosporin A  (ISO)
cypermethrin  (ISO)
cytarabine  (ISO)
D-glucose  (EXP)
Deoxycorticosterone acetate  (EXP)
dexamethasone  (ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (ISO)
dibenz[a,h]anthracene  (ISO)
dibutyl phthalate  (EXP)
dichlorine  (EXP)
diiodine  (ISO)
dimethyl sulfoxide  (EXP)
dioxygen  (EXP,ISO)
diprotium oxide  (EXP,ISO)
diquat  (ISO)
diuron  (EXP)
doxorubicin  (ISO)
etoposide  (ISO)
finasteride  (EXP)
flavonoids  (EXP)
flutamide  (EXP)
folpet  (ISO)
gallic acid  (ISO)
genistein  (ISO)
gentamycin  (EXP)
glucose  (EXP)
glycidol  (EXP)
GW 4064  (ISO)
hydrogen peroxide  (ISO)
indole-3-methanol  (EXP)
indometacin  (EXP)
iodide salt  (EXP)
kojic acid  (ISO)
lead(0)  (ISO)
lipopolysaccharide  (ISO)
lycopene  (ISO)
mercaptoethanol  (ISO)
mercury atom  (EXP,ISO)
mercury dichloride  (EXP,ISO)
mercury(0)  (EXP,ISO)
methapyrilene  (ISO)
methimazole  (EXP)
methylmercury chloride  (ISO)
morphine  (ISO)
N-methyl-N-nitrosourea  (ISO)
N-nitrosodiethylamine  (EXP)
naringin  (ISO)
nitrofen  (EXP)
nitrogen dioxide  (ISO)
ochratoxin A  (EXP)
Osajin  (ISO)
oxaliplatin  (EXP)
oxybenzone  (EXP)
ozone  (EXP,ISO)
p-chloromercuribenzenesulfonic acid  (ISO)
paracetamol  (ISO)
paraquat  (ISO)
PCB138  (ISO)
peptidoglycan  (ISO)
perchlorate  (EXP)
perfluorohexanesulfonic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenobarbital  (ISO)
pirinixic acid  (ISO)
Pomiferin  (ISO)
potassium chloride  (EXP)
potassium dichromate  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
progesterone  (EXP)
propiconazole  (ISO)
prostaglandin E2  (ISO)
puerarin  (ISO)
quercetin  (EXP)
resveratrol  (ISO)
roflumilast  (ISO)
Rosavin  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 203580  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (ISO)
streptozocin  (EXP)
sulindac  (EXP)
sunitinib  (ISO)
tamoxifen  (ISO)
tebuconazole  (EXP)
tert-butyl hydroperoxide  (ISO)
tetrachloromethane  (EXP,ISO)
tetraethylammonium  (ISO)
tetrathiomolybdate(2-)  (ISO)
thioacetamide  (EXP)
thiourea  (EXP)
titanium dioxide  (ISO)
topotecan  (EXP)
triadimefon  (ISO)
triclosan  (ISO)
Triptolide  (EXP)
tungsten  (ISO)
urethane  (ISO)
valproic acid  (EXP,ISO)
valsartan  (EXP)
verapamil  (ISO)
vinclozolin  (EXP)
vitamin E  (ISO)
water  (EXP,ISO)
zinc atom  (EXP)
zinc sulfate  (EXP)
zinc(0)  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
ammonium transmembrane transport  (ISO,ISS)
camera-type eye morphogenesis  (ISO)
carbon dioxide transmembrane transport  (IBA,ISO,ISS)
carbon dioxide transport  (ISO,ISS)
cell migration  (ISO)
cell volume homeostasis  (ISO,ISS)
cellular homeostasis  (ISO,ISS)
cellular hyperosmotic response  (ISO,ISS)
cellular response to cAMP  (ISO,ISS)
cellular response to copper ion  (ISO,ISS)
cellular response to dexamethasone stimulus  (ISO,ISS)
cellular response to hydrogen peroxide  (ISO,ISS)
cellular response to hypoxia  (ISO,ISS)
cellular response to inorganic substance  (ISO,ISS)
cellular response to mechanical stimulus  (ISO,ISS)
cellular response to mercury ion  (ISO,ISS)
cellular response to nitric oxide  (ISO)
cellular response to retinoic acid  (ISO,ISS)
cellular response to salt stress  (ISO,ISS)
cellular response to UV  (ISO,ISS)
cerebrospinal fluid secretion  (ISO)
cGMP-mediated signaling  (ISO,ISS)
corticotropin secretion  (ISO)
defense response to Gram-negative bacterium  (ISO)
establishment of localization in cell  (ISO)
establishment or maintenance of actin cytoskeleton polarity  (ISO,ISS)
fibroblast migration  (ISO)
glomerular filtration  (ISO)
glycerol transmembrane transport  (IDA,ISO)
hyperosmotic response  (IBA,IEP)
intracellular water homeostasis  (ISO,ISS)
lateral ventricle development  (IEP,ISO)
lipid digestion  (ISO)
metanephric descending thin limb development  (ISO)
metanephric glomerulus vasculature development  (ISO)
metanephric proximal convoluted tubule segment 2 development  (ISO)
metanephric proximal straight tubule development  (ISO)
metanephric proximal tubule development  (IEP)
multicellular organismal-level water homeostasis  (ISO)
negative regulation of apoptotic process  (ISO,ISS)
nitric oxide transport  (ISO,ISS)
odontogenesis  (ISO)
pancreatic juice secretion  (ISO)
positive regulation of angiogenesis  (ISO,ISS)
positive regulation of epithelial cell migration  (IMP)
positive regulation of fibroblast migration  (ISO)
positive regulation of fibroblast proliferation  (ISO,ISS)
positive regulation of lamellipodium assembly  (IMP)
positive regulation of saliva secretion  (ISO,ISS)
potassium ion transmembrane transport  (IEA)
potassium ion transport  (ISO)
renal water absorption  (ISO)
renal water transport  (IBA,ISO,ISS)
response to estrogen  (IEP)
response to hormone  (IEP)
secretion by cell  (ISO)
secretory granule organization  (ISO)
sensory perception of pain  (ISO)
transepithelial water transport  (ISO,ISS)
water transport  (IMP,ISO)
wound healing  (ISO)

Cellular Component


References - curated
# Reference Title Reference Citation
1. Evidence for a glycerol pathway through aquaporin 1 (CHIP28) channels. Abrami L, etal., Pflugers Arch. 1995 Jul;430(3):447-58.
2. Expression and regulation of aquaporins 1, 8, and 9 in the testis, efferent ducts, and epididymis of adult rats and during postnatal development. Badran HH and Hermo LS, J Androl 2002 May-Jun;23(3):358-73.
3. Hepatic cystogenesis is associated with abnormal expression and location of ion transporters and water channels in an animal model of autosomal recessive polycystic kidney disease. Banales JM, etal., Am J Pathol. 2008 Dec;173(6):1637-46. Epub 2008 Nov 6.
4. Angiotensin II and hypertonicity modulate proximal tubular aquaporin 1 expression. Bouley R, etal., Am J Physiol Renal Physiol. 2009 Dec;297(6):F1575-86. Epub 2009 Sep 23.
5. Isolation of a cDNA for rat CHIP28 water channel: high mRNA expression in kidney cortex and inner medulla. Deen PM, etal., Biochem Biophys Res Commun 1992 Nov 16;188(3):1267-73.
6. Human neuronal changes in brain edema and increased intracranial pressure. Faragó N, etal., Acta Neuropathol Commun. 2016 Aug 4;4(1):78. doi: 10.1186/s40478-016-0356-x.
7. Altered expression of aquaporins 1 and 4 coincides with neurodegenerative events in retinas of spontaneously diabetic Torii rats. Fukuda M, etal., Exp Eye Res. 2010 Jan;90(1):17-25. Epub 2009 Sep 11.
8. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
9. Involvement of aquaporin-1 in gastric epithelial cell migration during wound repair. Hayashi S, etal., Biochem Biophys Res Commun. 2009 Aug 28;386(3):483-7. Epub 2009 Jun 17.
10. The potential role of caveolin-1 in inhibition of aquaporins during the AVD. Jablonski EM and Hughes FM Jr, Biol Cell. 2006 Jan;98(1):33-42.
11. Aquaporin-1 in the choroid plexuses of developing mammalian brain. Johansson PA, etal., Cell Tissue Res. 2005 Dec;322(3):353-64. Epub 2005 Aug 26.
12. Differential expressions of aquaporin subtypes in astroglia in the hippocampus of chronic epileptic rats. Kim JE, etal., Neuroscience. 2009 Oct 20;163(3):781-9. Epub 2009 Jul 18.
13. Aquaporins in rat pancreatic interlobular ducts. Ko SB, etal., Am J Physiol Gastrointest Liver Physiol 2002 Feb;282(2):G324-31.
14. Aquaporins in the kidney. Kwon TH, etal., Handb Exp Pharmacol. 2009;(190):95-132. doi: 10.1007/978-3-540-79885-9_5.
15. Evidence for the presence of a Hg-inhibitable water-permeability pathway and aquaporin 1 in A5 salivary epithelial cells. Lazowski KW, etal., J Cell Physiol. 1995 Sep;164(3):613-9.
16. Downregulation of renal aquaporins in response to unilateral ureteral obstruction. Li C, etal., Am J Physiol Renal Physiol 2003 May;284(5):F1066-79.
17. Examination of rat salivary glands for the presence of the aquaporin CHIP. Li J, etal., Pflugers Arch 1994 Oct;428(5-6):455-60.
18. Severely impaired urinary concentrating ability in transgenic mice lacking aquaporin-1 water channels. Ma T, etal., J Biol Chem 1998 Feb 20;273(8):4296-9.
19. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
20. Renogenic characterization and in vitro differentiation of rat amniotic fluid stem cells into renal proximal tubular- and juxtaglomerular-like cells. Minocha E, etal., In Vitro Cell Dev Biol Anim. 2019 Feb;55(2):138-147. doi: 10.1007/s11626-018-00315-2. Epub 2019 Jan 15.
21. Aquaporin expression in blood-retinal barrier cells during experimental autoimmune uveitis. Motulsky E, etal., Mol Vis. 2010 Apr 3;16:602-10.
22. Aquaporin 1 immunoreactive enteric neurons in the rat ileum. Nagahama M, etal., Neurosci Lett. 2006 Mar 13;395(3):206-10. Epub 2005 Nov 23.
23. Immunolocalization of aquaporin-1 in the mechanoreceptive Ruffini endings in the periodontal ligament. Nandasena BG, etal., Brain Res. 2007 Jul 9;1157:32-40. Epub 2007 Apr 19.
24. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
25. Compensatory increase in AQP2, p-AQP2, and AQP3 expression in rats with diabetes mellitus. Nejsum LN, etal., Am J Physiol Renal Physiol 2001 Apr;280(4):F715-26.
26. Functional requirement of aquaporin-5 in plasma membranes of sweat glands. Nejsum LN, etal., Proc Natl Acad Sci U S A 2002 Jan 8;99(1):511-516.
27. Aquaporin 1 - a novel player in spinal cord injury. Nesic O, etal., J Neurochem. 2008 May;105(3):628-40. Epub 2008 Jan 28.
28. Expression of aquaporin 1 and 4 in a congenital hydrocephalus rat model. Paul L, etal., Neurosurgery. 2011 Feb;68(2):462-73.
29. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
30. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
31. Evidence of aquaporin involvement in human central pontine myelinolysis. Popescu BF, etal., Acta Neuropathol Commun. 2013 Jul 25;1(1):40. doi: 10.1186/2051-5960-1-40.
32. High-salt loading exacerbates increased retinal content of aquaporins AQP1 and AQP4 in rats with diabetic retinopathy. Qin Y, etal., Exp Eye Res. 2009 Nov;89(5):741-7. Epub 2009 Jul 9.
33. Effects of intravitreal triamcinolone acetonide on retinal gene expression in a rat model of central retinal vein occlusion. Rehak M, etal., Graefes Arch Clin Exp Ophthalmol. 2011 Aug;249(8):1175-83. Epub 2011 Apr 13.
34. GOA pipeline RGD automated data pipeline
35. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
36. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
37. Isolation of gene markers of differentiated and proliferating vascular smooth muscle cells. Shanahan CM, etal., Circ Res 1993 Jul;73(1):193-204.
38. Hydrocephalus in a rat model of Meckel Gruber syndrome with a TMEM67 mutation. Shim JW, etal., Sci Rep. 2019 Jan 31;9(1):1069. doi: 10.1038/s41598-018-37620-5.
39. Expression, localization, and regulation of aquaporin-1 to -3 in rat urothelia. Spector DA, etal., Am J Physiol Renal Physiol 2002 Jun;282(6):F1034-42.
40. [Changes of VEGF and AQPs gene and protein expression in rat brain tissue during hypoxic encephaledema]. Tian YM, etal., Zhongguo Ying Yong Sheng Li Xue Za Zhi. 2011 Feb;27(1):7-11.
41. Expression of aquaporins 1 and 4 in the brain of spontaneously hypertensive rats. Tomassoni D, etal., Brain Res. 2010 Apr 14;1325:155-63. Epub 2010 Feb 12.
42. 2-Methoxyestradiol inhibits the up-regulation of AQP4 and AQP1 expression after spinal cord injury. Wang YF, etal., Brain Res. 2011 Jan 25;1370:220-6. Epub 2010 Nov 16.
43. Cloning, functional analysis and cell localization of a kidney proximal tubule water transporter homologous to CHIP28. Zhang R, etal., J Cell Biol 1993 Jan;120(2):359-69.
44. Induction stage-dependent expression of vascular endothelial growth factor and aquaporin-1 in diethylstilbestrol-treated rat pituitary. Zhao W, etal., Eur J Histochem. 2009 Jan-Mar;53(1):53-60.
Additional References at PubMed
PMID:1373524   PMID:1510932   PMID:7521540   PMID:7530250   PMID:8576117   PMID:8584435   PMID:9013443   PMID:9096382   PMID:9321919   PMID:9369468   PMID:9405233   PMID:9806845  
PMID:9829975   PMID:9886922   PMID:10021457   PMID:10021464   PMID:10318966   PMID:10510269   PMID:10564231   PMID:10613915   PMID:10642600   PMID:10644730   PMID:10662735   PMID:10724035  
PMID:10795927   PMID:10836992   PMID:10839360   PMID:11001937   PMID:11034202   PMID:11035042   PMID:11076974   PMID:11078688   PMID:11121384   PMID:11573934   PMID:11891232   PMID:11914159  
PMID:11922632   PMID:12002613   PMID:12012207   PMID:12034763   PMID:12051745   PMID:12084581   PMID:12133842   PMID:12137589   PMID:12172703   PMID:12181190   PMID:12468529   PMID:12477932  
PMID:12522663   PMID:12676067   PMID:12745312   PMID:12766090   PMID:12801959   PMID:12855358   PMID:14521551   PMID:14527167   PMID:14561230   PMID:14637313   PMID:14644770   PMID:14675051  
PMID:14701836   PMID:15135660   PMID:15283758   PMID:15326289   PMID:15624322   PMID:15647389   PMID:15727941   PMID:15844003   PMID:15850448   PMID:15857386   PMID:15948717   PMID:15952169  
PMID:15998844   PMID:16008975   PMID:16179736   PMID:16407156   PMID:16476579   PMID:16508653   PMID:16525162   PMID:16565507   PMID:16574458   PMID:16596446   PMID:16646408   PMID:16682607  
PMID:16711029   PMID:16814974   PMID:16936111   PMID:16997459   PMID:17012249   PMID:17074307   PMID:17178220   PMID:17229677   PMID:17257750   PMID:17371871   PMID:17377981   PMID:17409744  
PMID:17566653   PMID:17628981   PMID:17632520   PMID:17636236   PMID:17638014   PMID:17645239   PMID:17673462   PMID:17700641   PMID:17876668   PMID:17890385   PMID:17898873   PMID:17936693  
PMID:17981899   PMID:18202181   PMID:18275976   PMID:18392839   PMID:18471415   PMID:18501347   PMID:18509662   PMID:18511455   PMID:18511498   PMID:18538351   PMID:18617525   PMID:18618131  
PMID:18665841   PMID:18762715   PMID:18795320   PMID:19056867   PMID:19179619   PMID:19268465   PMID:19273840   PMID:19298815   PMID:19424603   PMID:19537242   PMID:19545896   PMID:19584911  
PMID:19610096   PMID:19628672   PMID:19640902   PMID:19724054   PMID:20177708   PMID:20340000   PMID:20423836   PMID:20501409   PMID:20663307   PMID:20958229   PMID:21038658   PMID:21092464  
PMID:21118806   PMID:21197617   PMID:21215257   PMID:21244858   PMID:21251984   PMID:21500577   PMID:21677414   PMID:21705333   PMID:22028046   PMID:22166655   PMID:22334691   PMID:22419034  
PMID:22581383   PMID:22587908   PMID:22610042   PMID:22683574   PMID:22921298   PMID:22975633   PMID:22997161   PMID:23029347   PMID:23164158   PMID:23199524   PMID:23238222   PMID:23376485  
PMID:23533145   PMID:23942196   PMID:23962074   PMID:24328827   PMID:24364558   PMID:24570172   PMID:24777974   PMID:25184686   PMID:25341953   PMID:25416956   PMID:25441658   PMID:25451277  
PMID:25489856   PMID:25592135   PMID:25656365   PMID:25659484   PMID:26281310   PMID:26315345   PMID:26317897   PMID:26554235   PMID:26724476   PMID:27181510   PMID:27229103   PMID:27261598  
PMID:27424549   PMID:27779640   PMID:28344346   PMID:28525373   PMID:28733452   PMID:28798257   PMID:29303021   PMID:29357442   PMID:29956781   PMID:30060820   PMID:30864707   PMID:31063681  
PMID:31529146   PMID:31556577   PMID:31790718   PMID:31995798   PMID:32179955   PMID:32188840   PMID:33358303   PMID:33506920   PMID:36293145  


Comparative Map Data
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
GRCr8485,812,784 - 85,824,964 (+)NCBIGRCr8
mRatBN7.2484,482,512 - 84,494,690 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl484,482,512 - 84,494,690 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx489,700,946 - 89,713,083 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0485,476,356 - 85,488,493 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0483,882,115 - 83,894,263 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0485,551,503 - 85,563,683 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl485,551,502 - 85,569,360 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04150,203,461 - 150,215,641 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4484,098,346 - 84,110,524 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1484,384,810 - 84,396,991 (+)NCBI
Celera479,349,727 - 79,361,905 (+)NCBICelera
Cytogenetic Map4q24NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38730,911,853 - 30,925,516 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl730,911,853 - 30,925,517 (+)EnsemblGRCh38hg38GRCh38
GRCh37730,951,468 - 30,965,131 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36730,917,993 - 30,931,656 (+)NCBINCBI36Build 36hg18NCBI36
Build 34730,724,707 - 30,738,371NCBI
Celera730,940,621 - 30,954,337 (+)NCBICelera
Cytogenetic Map7p14.3NCBI
HuRef730,833,637 - 30,847,351 (+)NCBIHuRef
CHM1_1730,951,350 - 30,965,064 (+)NCBICHM1_1
T2T-CHM13v2.0731,049,501 - 31,063,163 (+)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v2731,000,921 - 31,014,637 (+)NCBI
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm39655,313,284 - 55,325,540 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl655,313,417 - 55,325,540 (+)EnsemblGRCm39 Ensembl
GRCm38655,336,299 - 55,348,555 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl655,336,432 - 55,348,555 (+)EnsemblGRCm38mm10GRCm38
MGSCv37655,286,293 - 55,298,549 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36655,266,010 - 55,278,133 (+)NCBIMGSCv36mm8
Celera655,870,108 - 55,882,362 (+)NCBICelera
Cytogenetic Map6B3NCBI
cM Map627.38NCBI
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0 EnsemblNW_00495541032,066,196 - 32,078,717 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541032,066,196 - 32,078,661 (+)NCBIChiLan1.0ChiLan1.0
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
NHGRI_mPanPan1-v2635,722,747 - 35,736,555 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1784,047,527 - 84,061,283 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0731,524,933 - 31,538,602 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1731,644,331 - 31,658,141 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl731,644,331 - 31,658,141 (+)Ensemblpanpan1.1panPan2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.11443,592,266 - 43,603,903 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1443,578,721 - 43,605,720 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1443,024,519 - 43,036,159 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01443,532,873 - 43,544,517 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1443,532,714 - 43,546,331 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11443,648,522 - 43,660,154 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01443,325,031 - 43,336,701 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01443,686,308 - 43,697,947 (+)NCBIUU_Cfam_GSD_1.0
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2NW_02440511887,935,407 - 87,948,638 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364787,147,027 - 7,160,401 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364787,146,997 - 7,160,369 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl1842,063,485 - 42,076,746 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11842,063,482 - 42,076,741 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.12127,456,553 - 27,473,196 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2127,456,259 - 27,470,728 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604277,234,082 - 77,247,886 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla_female_1.0 EnsemblNW_004624783164,609 - 177,766 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624783164,615 - 177,317 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Variants in Aqp1
36 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:684
Count of miRNA genes:282
Interacting mature miRNAs:358
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2303168Bp330Blood pressure QTL 3304.250.017arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)45214602146446691Rat
631261Tcas3Tongue tumor susceptibility QTL 36.88tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)41081417091360527Rat
2316958Gluco58Glucose level QTL 5810blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)411320076180699135Rat
12798520Anxrr55Anxiety related response QTL 554.450.01locomotor behavior trait (VT:0001392)number of rearing movements with lid-pushing in an experimental apparatus (CMO:0002715)432583980114627242Rat
8655961Kidm43Kidney mass QTL 4318kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)436303261103194984Rat
1358352Srcrt3Stress Responsive Cort QTL 32.29blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)438465774146803430Rat
1300139Hrtrt6Heart rate QTL 62.85heart pumping trait (VT:2000009)heart rate (CMO:0000002)439524264116179656Rat
61445Strs3Sensitivity to stroke QTL 33cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)44043338885433388Rat
8694439Bw168Body weight QTL 1689.570.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)44043341485433414Rat
6893678Bw108Body weight QTL 1082.60.006body mass (VT:0001259)body weight (CMO:0000012)44345797688457976Rat
1576305Emca6Estrogen-induced mammary cancer QTL 65.8mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)444463720155883716Rat
1354612Foco1Food consumption QTL 18.87eating behavior trait (VT:0001431)food intake rate (CMO:0000427)444463908148090542Rat
1354660Salc1Saline consumption QTL 111.26drinking behavior trait (VT:0001422)saline drink intake rate (CMO:0001627)444463908148090542Rat
2312567Glom19Glomerulus QTL 191.90.006kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)445456990146803430Rat
1298082Stresp4Stress response QTL 4blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)450119848146803430Rat
70200Alc18Alcohol consumption QTL 189.2drinking behavior trait (VT:0001422)ethanol intake volume to total fluid intake volume ratio (CMO:0001591)456647873149491524Rat
1641833Alc21Alcohol consumption QTL 218.60.0001drinking behavior trait (VT:0001422)ethanol drink intake rate (CMO:0001407)456698790126192555Rat
631546Bp86Blood pressure QTL 863.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)45711443291360801Rat
1358363Sradr3Stress Responsive Adrenal Weight QTL 36.19adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)457486946102486946Rat
1558651Swd3Spike wave discharge measurement QTL 34.620.000024brain electrophysiology trait (VT:0010557)brain spike-and-wave discharge frequency (CMO:0001742)45843213392991462Rat
738009Sach4Saccharine consumption QTL 44.90.000016consumption behavior trait (VT:0002069)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)459948935154902892Rat
738016Alc16Alcohol consumption QTL 163.60.00015consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)459948935154902892Rat
738031Alc14Alcohol consumption QTL 147.60.00003consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)459948935154902892Rat
1578657Bss12Bone structure and strength QTL 128.9femur morphology trait (VT:0000559)femoral neck cross-sectional area (CMO:0001697)460220938105220938Rat
1578658Bss13Bone structure and strength QTL 138femur strength trait (VT:0010010)femoral neck polar moment of inertia (CMO:0001670)460220938105220938Rat
2300179Bmd50Bone mineral density QTL 505.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)460928534105928534Rat
1549843Bw53Body weight QTL 530.0001body mass (VT:0001259)body weight gain (CMO:0000420)461697658103194791Rat
1549839Bw52Body weight QTL 520.0001body mass (VT:0001259)body weight gain (CMO:0000420)461697658115089733Rat
61418Pia5Pristane induced arthritis QTL 54.5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)462277855128289560Rat
6478743Anxrr40Anxiety related response QTL 400.83076defecation behavior trait (VT:0010462)defecation rate (CMO:0000998)462753847107753847Rat
6478772Anxrr49Anxiety related response QTL 490.15488defecation behavior trait (VT:0010462)defecation rate (CMO:0000998)462753847107753847Rat
6478684Anxrr30Anxiety related response QTL 300.00087defecation behavior trait (VT:0010462)defecation rate (CMO:0000998)462753847107753847Rat
631651Bp124Blood pressure QTL 1243arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)462879517107879517Rat
7394826Bw126Body weight QTL 1260.002body mass (VT:0001259)body weight gain (CMO:0000420)46293326987483707Rat
70192BpQTLcluster5Blood pressure QTL cluster 54.183arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)462933508114921294Rat
70192BpQTLcluster5Blood pressure QTL cluster 54.183arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)462933508114921294Rat
70192BpQTLcluster5Blood pressure QTL cluster 54.183arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)462933508114921294Rat
70192BpQTLcluster5Blood pressure QTL cluster 54.183arterial blood pressure trait (VT:2000000)percent change in mean arterial blood pressure (CMO:0002035)462933508114921294Rat
70192BpQTLcluster5Blood pressure QTL cluster 54.183arterial blood pressure trait (VT:2000000)percent change in systolic blood pressure (CMO:0000747)462933508114921294Rat
70192BpQTLcluster5Blood pressure QTL cluster 54.183arterial blood pressure trait (VT:2000000)absolute change in pulse pressure (CMO:0001882)462933508114921294Rat
70192BpQTLcluster5Blood pressure QTL cluster 54.183arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)462933508114921294Rat
631674Iddm14Insulin dependent diabetes mellitus QTL 14blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)464528739157573521Rat
2312569Pur19Proteinuria QTL 193.40.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)46588210796130297Rat
61330Eau1Experimental allergic uveoretinitis QTL 10.0003uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)470362013132642728Rat
634344Hcar7Hepatocarcinoma resistance QTL 77.8liver integrity trait (VT:0010547)liver tumorous lesion area to total liver area ratio (CMO:0001075)470808386115808386Rat
634344Hcar7Hepatocarcinoma resistance QTL 77.8liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)470808386115808386Rat
631646Stl4Serum triglyceride level QTL 46.50.0001blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)473169846132642728Rat
724522Bp146Blood pressure QTL 1462.20.0021arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)473630210118630210Rat
2302051Pia28Pristane induced arthritis QTL 285.30.001blood autoantibody amount (VT:0003725)serum immunoglobulin G-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002112)473630210118630210Rat
70167Bw22Body weight QTL 223.1body mass (VT:0001259)body weight (CMO:0000012)476647384117676292Rat
1357342Bw40Body weight QTL 400.001body mass (VT:0001259)body weight (CMO:0000012)476647384117676292Rat
631662Hcar2Hepatocarcinoma resistance QTL 23.10.0003liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)478878504123878504Rat
631556Bp135Blood pressure QTL 1350.017arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)478881294117676292Rat
61364Iddm2Insulin dependent diabetes mellitus QTL 2blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)478885890102684881Rat
738015Pia9Pristane induced arthritis QTL 94.50.048joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)480694870125694870Rat
2306899Bp338Blood pressure QTL 3380.071arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)481006124120102625Rat
1641919Alc22Alcohol consumption QTL 220.0005drinking behavior trait (VT:0001422)ethanol drink intake rate (CMO:0001407)481192555126192555Rat
70177Xhs1X-ray hypersensitivity QTL 125.1intestine integrity trait (VT:0010554)post-insult time to onset of moribundity (CMO:0001896)482798864152731274Rat
2306794Ean2Experimental allergic neuritis QTL 26.4nervous system integrity trait (VT:0010566)IFNG-secreting splenocyte count (CMO:0002122)48342841995853334Rat
1576316Ept5Estrogen-induced pituitary tumorigenesis QTL 53.8pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)483428419177635233Rat

Markers in Region
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2484,494,282 - 84,494,479 (+)MAPPERmRatBN7.2
Rnor_6.0485,563,276 - 85,563,472NCBIRnor6.0
Rnor_5.04150,215,234 - 150,215,430UniSTSRnor5.0
RGSC_v3.4484,110,117 - 84,110,313UniSTSRGSC3.4
Celera479,361,498 - 79,361,694UniSTS
RH 3.4 Map4526.6UniSTS
Cytogenetic Map4q24UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2484,492,064 - 84,493,114 (+)MAPPERmRatBN7.2
Rnor_6.0485,561,058 - 85,562,107NCBIRnor6.0
Rnor_5.04150,213,016 - 150,214,065UniSTSRnor5.0
Celera479,359,280 - 79,360,329UniSTS
Cytogenetic Map4q24UniSTS

Related Rat Strains
The following Strains have been annotated to Aqp1


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High 1
Medium 3 43 34 18 19 18 8 11 23 30 23 11 8
Low 23 23 23 47 4 16
Below cutoff 4 2


RefSeq Acc Id: ENSRNOT00000015692   ⟹   ENSRNOP00000015692
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl484,482,512 - 84,494,690 (+)Ensembl
Rnor_6.0 Ensembl485,551,503 - 85,563,683 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000087191   ⟹   ENSRNOP00000072600
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl485,551,502 - 85,569,360 (+)Ensembl
RefSeq Acc Id: NM_012778   ⟹   NP_036910
Rat AssemblyChrPosition (strand)Source
GRCr8485,812,784 - 85,824,964 (+)NCBI
mRatBN7.2484,482,512 - 84,494,690 (+)NCBI
Rnor_6.0485,551,503 - 85,563,683 (+)NCBI
Rnor_5.04150,203,461 - 150,215,641 (+)NCBI
RGSC_v3.4484,098,346 - 84,110,524 (+)RGD
Celera479,349,727 - 79,361,905 (+)RGD
RefSeq Acc Id: NP_036910   ⟸   NM_012778
- UniProtKB: Q5EB50 (UniProtKB/Swiss-Prot),   Q7TN36 (UniProtKB/Swiss-Prot),   P29975 (UniProtKB/Swiss-Prot),   A6K0X8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000072600   ⟸   ENSRNOT00000087191
RefSeq Acc Id: ENSRNOP00000015692   ⟸   ENSRNOT00000015692

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P29975-F1-model_v2 AlphaFold P29975 1-269 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13693081
Promoter ID:EPDNEW_R3598
Type:single initiation site
Description:aquaporin 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database,
Experiment Methods:Single-end sequencing.
Rat AssemblyChrPosition (strand)Source
Rnor_6.0485,551,503 - 85,551,563EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2141 AgrOrtholog
BioCyc Gene G2FUF-44733 BioCyc
Ensembl Genes ENSRNOG00000011648 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOG00055010900 UniProtKB/Swiss-Prot
  ENSRNOG00060022640 UniProtKB/Swiss-Prot
  ENSRNOG00065011980 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000015692 ENTREZGENE
  ENSRNOT00000015692.3 UniProtKB/Swiss-Prot
  ENSRNOT00055018453 UniProtKB/Swiss-Prot
  ENSRNOT00060039288 UniProtKB/Swiss-Prot
  ENSRNOT00065019471 UniProtKB/Swiss-Prot
Gene3D-CATH 1.20.1080.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Aquaporin-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Aquaporin_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Aquaporin_transptr UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MIP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MIP_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:25240 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  AQUAPORIN-1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR19139 UniProtKB/Swiss-Prot
Pfam MIP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Aqp1 PhenoGen
  MINTRINSICP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE MIP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000011648 RatGTEx
  ENSRNOG00055010900 RatGTEx
  ENSRNOG00060022640 RatGTEx
  ENSRNOG00065011980 RatGTEx
Superfamily-SCOP Aquaporin-like UniProtKB/TrEMBL, UniProtKB/Swiss-Prot
UniProt Secondary Q5EB50 UniProtKB/Swiss-Prot
  Q7TN36 UniProtKB/Swiss-Prot

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-11-11 Aqp1  aquaporin 1  Aqp1  aquaporin 1 (Colton blood group)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2019-03-27 Aqp1  aquaporin 1 (Colton blood group)  Aqp1  aquaporin 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Aqp1  aquaporin 1       Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_cellular_localization localizes to basolateral and luminal membranes 70596
gene_drugs basolateral and luminal application of isotonic HEPES-buffered solution containing HgCl2 induced concentration-dependent inhibition of osmotic water permeability of the ducts, preincubation with DMSO [500mM] inhibits the water permeability 70596
gene_expression expressed in renal proximal tubules and paw capillary endothelial cells 70240
gene_expression expressed in interlobular duct cells of pancreas 70596
gene_expression expressed in capillary and arteriole endothelial cells 70596
gene_expression expressed in kidney with highest expression in renal inner medulla 1298548
gene_expression expressed in epithelial cells in proximal tubule and thin descending limb of Henle 1298577
gene_expression expressed in salivary glands 1298674
gene_function water channel protein 67997
gene_function appears to be the main water channel in pancreatic interlobular ducts 70596
gene_function mercury-sensitive, water channel protein 70596
gene_function fluid transport molecule 1298548
gene_function major water transport protein in the kidney proximal tubule 1298577
gene_function water channel in kidney and red blood cells 1298674
gene_process plays a critical role in urinary concentration 67997
gene_process regulates the epithelial cell volume and responsible for bulk water movement across the urothelia 70596
gene_process responsible for approximately 90% of the water transport into the pancreatic duct lumen 70596
gene_process responsible for nephron water transport 70596
gene_process may induce water permeability in salivary gland capillary beds 1298674
gene_protein 29 kDa protein 70596
gene_protein 28kDa protein 1298577