Iddm2 QTL Report (Rattus norvegicus) - Rat Genome Database

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QTL Registration

QTL: Iddm2 (Insulin dependent diabetes mellitus QTL 2) Rattus norvegicus

Symbol: Iddm2
Name: Insulin dependent diabetes mellitus QTL 2
RGD ID: 61364
Previously known as: Iddm1
Trait: blood glucose amount   (VT:0000188)    
Measurement Type: blood glucose level   (CMO:0000046)    
LOD Score: Not Available
P Value: Not Available
Variance: Not Available
Position
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8480,216,705 - 104,243,248RGD_MAPPER_PIPELINE
mRatBN7.2478,885,890 - 102,684,881RGD_MAPPER_PIPELINEmRatBN7.2
Rnor_6.0479,562,451 - 98,542,106RGD_MAPPER_PIPELINERnor6.0
Cross Type: F2
Strains Crossed: BBDP/Rhw BBDR/Rhw 
JBrowse: View Region in Genome Browser (JBrowse)
Model




  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Iddm2Rattype 1 diabetes mellitus  IDA 61075 RGD 

Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Iddm2Ratincreased circulating glucose level  QTM 61075 RGD 

Clinical Measurement
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Iddm2Ratblood glucose level  IDA 61075 RGD 

Experimental Condition
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Iddm2Ratcontrol condition  IDA 61075 RGD 

Measurement Method
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Iddm2Ratblood glucose analysis  IDA 61075 RGD 

Rat Strain
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Iddm2RatBBDP/Rhw  IEA 61075 RGD 
Iddm2RatBBDR/Rhw  IEA 61075 RGD 

Vertebrate Trait
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Iddm2Ratblood glucose amount  IDA 61075 RGD 


#
Reference Title
Reference Citation
1. Genetic isolation of iddm 1 on chromosome 4 in the biobreeding (BB) rat. Bieg S, etal., Mamm Genome 1998 Apr;9(4):324-6
2. Genetic dissection of autoimmune type I diabetes in the BB rat Jacob HJ, etal., Nat Genet 1992 Sep;2(1):56-60
3. BB rat diabetes susceptibility and body weight regulation genes colocalize on chromosome 2. Klaff LS, etal., Mamm Genome 1999 Sep;10(9):883-7
4. Identification of genomic regions controlling experimental autoimmune uveoretinitis in rats. Sun SH, etal., Int Immunol 1999 Apr;11(4):529-34

Related QTL Description Reference
Eau1 maps to same region RGD:61073
Iddm1 interacts with RGD:61075



1 to 20 of 305 rows
The following Genes overlap with this region.    Full Report CSV TAB Printer Analysis Tools
RGD ID
Symbol
Name
Chr
Start
Stop
Species
3197Npyneuropeptide Y47888129478888495Rat
7571074LOC102555694uncharacterized LOC10255569447903911779041508Rat
41298329LOC120102516basic proline-rich protein-like47916687779179773Rat
1311833Pals2protein associated with LIN7 2, MAGUK p55 family member47917348879257542Rat
727871Gsdmegasdermin E47925879979321129Rat
1564287Osbpl3oxysterol binding protein-like 347934658379523523Rat
41162112LOC120102268uncharacterized LOC12010226847952343879529558Rat
41061164LOC120102676small nucleolar RNA SNORA1747962350279623632Rat
1565415Rpl27al5ribosomal protein L27A like 547963353979634311Rat
2451Cycscytochrome c, somatic47965189479653994Rat
7624339LOC102546410uncharacterized LOC10254641047965417279689329Rat
1563788Spmip4sperm microtubule inner protein 447966337579688291Rat
61815Npvfneuropeptide VF precursor47971235879716275Rat
11401676LOC108350707uncharacterized LOC10835070747979076779795915Rat
1593814Aurka-ps3aurora kinase A, pseudogene 347981143179812875Rat
2319193Rpl36a-ps13ribosomal protein L36A, pseudogene 1347985997579860338Rat
7508808LOC102546824uncharacterized LOC10254682447999538680054736Rat
41052635LOC120102269uncharacterized LOC12010226948011040280114314Rat
41083837LOC120102163uncharacterized LOC12010216348018866680191301Rat
1592878Cux1-ps1cut-like homeobox 1, pseudogene 148026981580272663Rat

1 to 20 of 305 rows
1 to 20 of 335 rows
The following Markers overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Expected Size
Chr
Start
Stop
Species
Match
10782D4Mit81044102684777102684881Ratregion
11012D4Wox2214847888598978886137Ratregion
11013D4Arb729047888586778886157Ratregion
11014D4Mit729947888589078886189Ratregion
33905D4Mit1127449136052791360801Ratregion
36378D4Mgh3321248615232386152535Ratregion
35190D4Rat22714347973494979735095Ratregion
35286D4Rat3714249330831593308457Ratregion
35325D4Rat4117449613012396130297Ratregion
35409D4Rat3419148537942185379614Ratregion
36870D4Rat3315548100612481006281Ratregion
36978D4Rat3814149585319395853334Ratregion
37646D4Rat10813848284404882844186Ratregion
37906D4Rat12720347934020379340408Ratregion
36544D4Rat7716549512805695128221Ratregion
35669D4Rat3516449136661091366774Ratregion
35721D4Rat7619848525374885253946Ratregion
38262D4Rat10321648342841983428649Ratregion
40586D4Rat23122248865668188656903Ratregion
40640D4Rat17125048821695788217207Ratregion
1 to 20 of 335 rows

Flank 1: (D4Mit7)
Rat AssemblyChrPosition (strand)Source
GRCr8480,216,705 - 80,217,004 (+)Marker Load Pipeline
mRatBN7.2478,885,890 - 78,886,189 (+)MAPPER
Rnor_6.0479,562,451 - 79,562,753RGD
Peak: (D4Mit7)
Rat AssemblyChrPosition (strand)Source
GRCr8480,216,705 - 80,217,004 (+)Marker Load Pipeline
mRatBN7.2478,885,890 - 78,886,189 (+)MAPPER
Rnor_6.0479,562,451 - 79,562,753RGD
Flank 2: (D4Mit8)
Rat AssemblyChrPosition (strand)Source
GRCr84104,243,144 - 104,243,248 (+)Marker Load Pipeline
mRatBN7.24102,684,777 - 102,684,881 (+)MAPPER
Rnor_6.0498,542,003 - 98,542,106RGD


1 to 10 of 74 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
1582232Gluco25Glucose level QTL 253.60.0023blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)485253748148090731Rat
631689Scl4Serum cholesterol level QTL 41.90.008blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)495174120140174120Rat
1358352Srcrt3Stress Responsive Cort QTL 32.29blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)438465774146803430Rat
1549843Bw53Body weight QTL 530.0001body mass (VT:0001259)body weight gain (CMO:0000420)461697658103194791Rat
61445Strs3Sensitivity to stroke QTL 33cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)44043338885433388Rat
6893678Bw108Body weight QTL 1082.60.006body mass (VT:0001259)body weight (CMO:0000012)44345797688457976Rat
1578655Bmd11Bone mineral density QTL 1111femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)490850165135850165Rat
10755501Bp390Blood pressure QTL 3902.5arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)426775591168368347Rat
1357342Bw40Body weight QTL 400.001body mass (VT:0001259)body weight (CMO:0000012)476647384117676292Rat
631556Bp135Blood pressure QTL 1350.017arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)478881294117676292Rat

1 to 10 of 74 rows


Database
Acc Id
Source(s)
NCBI Gene Iddm2


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2001-01-19 Iddm2  Insulin-dependent diabetes mellitus QTL 2      QTL symbol assigned 61482 APPROVED
2001-01-19 Iddm1  Insulin-dependent diabetes mellitus QTL 1      QTL symbol reassigned 61482 WITHDRAWN

Note Type Note Reference
qtl_gene Lymphopenia gene is linked to autoimmune diabetes in the BB rats. 631162
qtl_general the odds of linkage to the QTL is 200:1; lymphopenia is essential for the development of diabetes 61075
qtl_general a congenic strain BBDR.BBDP-(D4Mit6-D4Mit24) was developed to study the pathogenesis of diabetes which was controlled by this locus 61032