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Strain: BBDP/Rhw

Symbol: BBDP/Rhw
Strain: BBDP
Substrain: Rhw
RGD ID: 10002
Citation ID: RRID:RGD_10002
Ontology ID: RS:0000071
Type: inbred
Source: Not Available
Origin: S. Bieg and coworkers (1998) generated a congenic line in which diabetes and lymphopenia are controlled solely by Iddm 1. This strain was generated by nine cycles of cross-intercross breeding of diabetes-prone DP with DR BB rats. Iddm 1 in the BioBreeding (BB) rat designates the genomic region on rat Chromosome (Chr) 4 that harbors the gene causing peripheral T cell lymphopenia (Lyp) and diabetes. The average age of onset of diabetes was 85 ± 53 days of age after the first and 67 ± 10 days of age after the 9th cycle.
Last Known Status: Unknown





Disease Annotations     Click to see Annotation Detail View


References

References - curated
# Reference Title Reference Citation
1. Genetic isolation of iddm 1 on chromosome 4 in the biobreeding (BB) rat. Bieg S, etal., Mamm Genome 1998 Apr;9(4):324-6
2. Spontaneous diabetes mellitus syndrome in the rat. I. Association with the major histocompatibility complex. Colle E, etal., J Exp Med 1981 Oct 1;154(4):1237-42
3. Inbred Strains Festing, MFW, Inbred Strains, The Laboratory Rat, 1979, Baker HK, Lindsey JR, Weisbroth SH, 55-72, Academic Press
4. Update to previous Strain Data Festing, MFW, Personal Communication Update, Feb-2000
5. Introgression of F344 Rat Genomic DNA on BB Rat Chromosome 4 Generates Diabetes-Resistant Lymphopenic BB Rats. Fuller JM, etal., Diabetes. 2006 Dec;55(12):3351-7.
6. Genetic Dissection Reveals Diabetes Loci Proximal to the Gimap5 Lymphopenia Gene. Fuller JM, etal., Physiol Genomics. 2009 Apr 7.
7. Genetic dissection of autoimmune type I diabetes in the BB rat Jacob HJ, etal., Nat Genet 1992 Sep;2(1):56-60
8. Non-major histocompatibility complex-linked diabetes susceptibility loci on chromosomes 4 and 13 in a backcross of the DP-BB/Wor rat to the WF rat. Martin AM, etal., Diabetes 1999 Jan;48(1):50-8
9. RGD Strain RSO annotation pipeline RGD Automated Pipelines

Region

Strain QTL Data
Symbol Name Trait
Iddm1 Insulin dependent diabetes mellitus QTL 1 blood glucose amount   (VT:0000188)    
Iddm2 Insulin dependent diabetes mellitus QTL 2 blood glucose amount   (VT:0000188)    

Additional Information

RGD Curation Notes
Note Type Note Reference
strain_characteristics This strain is Diabetic Prone 61032
strain_infection These are infected by Ljungan virus (LV) which induces glucose intolerance 1601199
strain_reproduction Average litter size at weaning 6.5 pups for diabetic-prone colonies. 61032