Strain Report - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Strain Registration

Strain: BBDP/Rhw

Symbol: BBDP/Rhw
Strain: BBDP
Substrain: Rhw
RGD ID: 10002
Citation ID: RRID:RGD_10002
Ontology ID: RS:0000071
Type: inbred
Available Source: Not Available
Description: S. Bieg and coworkers (1998) generated a congenic line in which diabetes and lymphopenia are controlled solely by Iddm 1. This strain was generated by nine cycles of cross-intercross breeding of diabetes-prone DP with DR BB rats. Iddm 1 in the BioBreeding (BB) rat designates the genomic region on rat Chromosome (Chr) 4 that harbors the gene causing peripheral T cell lymphopenia (Lyp) and diabetes. The average age of onset of diabetes was 85 ± 53 days of age after the first and 67 ± 10 days of age after the 9th cycle.
Last Known Status: Unknown





Experimental Data Annotations    Click to see Annotation Detail View

Rat Strain
Object SymbolSpeciesTermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
BBDP/RhwRatBBDP/Rhw  IEA 7241799 RGD 

Vertebrate Trait
Object SymbolSpeciesTermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
BBDP/RhwRatblood glucose amount  EXP 61075 RGD 

Disease Annotations     Click to see Annotation Detail View


References

References - curated
# Reference Title Reference Citation
1. Genetic isolation of iddm 1 on chromosome 4 in the biobreeding (BB) rat. Bieg S, etal., Mamm Genome 1998 Apr;9(4):324-6
2. Spontaneous diabetes mellitus syndrome in the rat. I. Association with the major histocompatibility complex. Colle E, etal., J Exp Med 1981 Oct 1;154(4):1237-42
3. Inbred Strains Festing, MFW, Inbred Strains, The Laboratory Rat, 1979, Baker HK, Lindsey JR, Weisbroth SH, 55-72, Academic Press
4. Update to previous Strain Data Festing, MFW, Personal Communication Update, Feb-2000
5. Introgression of F344 Rat Genomic DNA on BB Rat Chromosome 4 Generates Diabetes-Resistant Lymphopenic BB Rats. Fuller JM, etal., Diabetes. 2006 Dec;55(12):3351-7.
6. Genetic Dissection Reveals Diabetes Loci Proximal to the Gimap5 Lymphopenia Gene. Fuller JM, etal., Physiol Genomics. 2009 Apr 7.
7. Genetic dissection of autoimmune type I diabetes in the BB rat Jacob HJ, etal., Nat Genet 1992 Sep;2(1):56-60
8. Non-major histocompatibility complex-linked diabetes susceptibility loci on chromosomes 4 and 13 in a backcross of the DP-BB/Wor rat to the WF rat. Martin AM, etal., Diabetes 1999 Jan;48(1):50-8
9. RGD Strain RSO annotation pipeline RGD Automated Pipelines

Region

Strain QTL Data
Symbol Name Trait
Iddm1 Insulin dependent diabetes mellitus QTL 1 blood glucose amount   (VT:0000188)    
Iddm2 Insulin dependent diabetes mellitus QTL 2 blood glucose amount   (VT:0000188)    

Additional Information

RGD Curation Notes
Note Type Note Reference
strain_characteristics This strain is Diabetic Prone 61032
strain_infection These are infected by Ljungan virus (LV) which induces glucose intolerance 1601199
strain_reproduction Average litter size at weaning 6.5 pups for diabetic-prone colonies. 61032