RGD Reference Report - Genetic dissection of autoimmune type I diabetes in the BB rat - Rat Genome Database

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Genetic dissection of autoimmune type I diabetes in the BB rat

Authors: Jacob, HJ  Pettersson, A  Wilson, D  Mao, Y  Lernmark, A  Lander, ES 
Citation: Jacob HJ, etal., Nat Genet 1992 Sep;2(1):56-60
RGD ID: 61075
Pubmed: PMID:1303251   (View Abstract at PubMed)
DOI: DOI:10.1038/ng0992-56   (Journal Full-text)

The BB rat is among the best models of insulin-dependent diabetes mellitus--with onset and pathogenesis closely resembling the human disease. One unusual feature is a severe T-cell lymphopenia, which appears to be inherited as a recessive trait controlled by a single gene, Lyp. Based on genetic analysis of several crosses, we show that development of diabetes involves at least three genes: Lyp, which is tightly linked to the neuropeptide Y (Npy) gene on chromosome 4, a gene linked to the major histocompatibility complex (MHC) on chromosome 20, and a third unmapped gene for which the Fischer rat strain carries an allele conferring resistance.

RGD Manual Disease Annotations    Click to see Annotation Detail View

Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Iddm1Rattype 1 diabetes mellitus  IDA  RGD 
Iddm2Rattype 1 diabetes mellitus  IDA  RGD 
Iddm3Rattype 1 diabetes mellitus  IDA  RGD 

Phenotype Annotations    Click to see Annotation Detail View

Mammalian Phenotype

Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Iddm2Ratincreased circulating glucose level  QTM  RGD 
Iddm3Ratincreased circulating glucose level  QTM  RGD 
Iddm4Ratincreased circulating glucose level  IAGP  RGD 
Iddm1Ratincreased T cell number  IDA  RGD 
Iddm3Ratobese  QTM  RGD 
Objects Annotated

Iddm1  (Insulin dependent diabetes mellitus QTL 1)
Iddm2  (Insulin dependent diabetes mellitus QTL 2)
Iddm3  (Insulin dependent diabetes mellitus QTL 3)
Iddm4  (Insulin dependent diabetes mellitus QTL 4)

BBDP/Rhw  (NA)
BBDR/Rhw  (NA)
LEW  (Lewis)

Objects referenced in this article
Marker D4Mit8 D4Mit8 Rattus norvegicus
Marker D4Mit7 D4Mit7 Rattus norvegicus
Strain BB/OK BioBreeding rat Rattus norvegicus
Strain DA DA Rattus norvegicus
Strain F344/NRrrc null Rattus norvegicus
Strain SHR Spontaneously Hypertensive Rat Rattus norvegicus

Additional Information