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Genetic dissection of autoimmune type I diabetes in the BB rat

Authors: Jacob, HJ  Pettersson, A  Wilson, D  Mao, Y  Lernmark, A  Lander, ES 
Citation: Jacob HJ, etal., Nat Genet 1992 Sep;2(1):56-60
Pubmed: (View Article at PubMed) PMID:1303251
DOI: Full-text: DOI:10.1038/ng0992-56

The BB rat is among the best models of insulin-dependent diabetes mellitus--with onset and pathogenesis closely resembling the human disease. One unusual feature is a severe T-cell lymphopenia, which appears to be inherited as a recessive trait controlled by a single gene, Lyp. Based on genetic analysis of several crosses, we show that development of diabetes involves at least three genes: Lyp, which is tightly linked to the neuropeptide Y (Npy) gene on chromosome 4, a gene linked to the major histocompatibility complex (MHC) on chromosome 20, and a third unmapped gene for which the Fischer rat strain carries an allele conferring resistance.

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RGD ID: 61075
Created: 2000-12-21
Species: All species
Last Modified: 2002-07-01
Status: ACTIVE



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