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Gene: Snca (synuclein alpha) Rattus norvegicus
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Symbol: Snca
Name: synuclein alpha
Description: Exhibits several functions, including cytoskeletal protein binding activity; phospholipase binding activity; and protein N-terminus binding activity. Involved in several processes, including aging; behavioral response to cocaine; and negative regulation of nitrogen compound metabolic process. Localizes to several cellular components, including the cytoplasm; distal axon; and nuclear outer membrane. Predicted to colocalize with the platelet alpha granule membrane. Used to study Parkinson's disease and amphetamine abuse. Biomarker of mental depression and neurilemmoma. Human ortholog(s) of this gene implicated in Alzheimer's disease; Lewy body dementia; Parkinson's disease; autosomal dominant Parkinson's disease 1; and autosomal dominant Parkinson's disease 4. Orthologous to human SNCA (synuclein alpha); PARTICIPATES IN Parkinson's disease pathway; altered ubiquitin/proteasome degradation pathway; Alzheimer's disease pathway; INTERACTS WITH (S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE; 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: alpha-synuclein; MGC105443; synuclein, alpha; synuclein, alpha (non A4 component of amyloid precursor); truncated alpha synuclein
Orthologs:
Homo sapiens (human) : SNCA (synuclein alpha)  HGNC  Alliance
Mus musculus (house mouse) : Snca (synuclein, alpha)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Snca (synuclein alpha)
Pan paniscus (bonobo/pygmy chimpanzee) : SNCA (synuclein alpha)
Canis lupus familiaris (dog) : SNCA (synuclein alpha)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Snca (synuclein alpha)
Sus scrofa (pig) : SNCA (synuclein alpha)
more info ...
Is Marker For: Strains:   NP.P-(D4Rat119-D4Rat55)/Iusm   P/Iusm   NP/Iusm   P.NP-(Snca-D4Rat35)/Iusm  
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0490,782,412 - 90,883,236 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.04155,592,411 - 155,690,724 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4489,613,731 - 89,722,807 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1489,858,155 - 89,967,232 (-)NCBI
Celera484,478,545 - 84,578,894 (-)NCBICelera
Cytogenetic Map4q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated
RGD Disease Portals

Genomics

Candidate Gene Status
Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
Related Rat Strains
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 5.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Snca
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 3729
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2019-07-23
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.