RGD Reference Report - Axon pathology in Parkinson's disease and Lewy body dementia hippocampus contains alpha-, beta-, and gamma-synuclein. - Rat Genome Database

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Axon pathology in Parkinson's disease and Lewy body dementia hippocampus contains alpha-, beta-, and gamma-synuclein.

Authors: Galvin, JE  Uryu, K  Lee, VM  Trojanowski, JQ 
Citation: Galvin JE, etal., Proc Natl Acad Sci U S A. 1999 Nov 9;96(23):13450-5.
RGD ID: 6480095
Pubmed: PMID:10557341   (View Abstract at PubMed)
PMCID: PMC23968   (View Article at PubMed Central)

Pathogenic alpha-synuclein (alphaS) gene mutations occur in rare familial Parkinson's disease (PD) kindreds, and wild-type alphaS is a major component of Lewy bodies (LBs) in sporadic PD, dementia with LBs (DLB), and the LB variant of Alzheimer's disease, but beta-synuclein (betaS) and gamma-synuclein (gammaS) have not yet been implicated in neurological disorders. Here we show that in PD and DLB, but not normal brains, antibodies to alphaS and betaS reveal novel presynaptic axon terminal pathology in the hippocampal dentate, hilar, and CA2/3 regions, whereas antibodies to gammaS detect previously unrecognized axonal spheroid-like lesions in the hippocampal dentate molecular layer. The aggregation of other synaptic proteins and synaptic vesicle-like structures in the alphaS- and betaS-labeled hilar dystrophic neurites suggests that synaptic dysfunction may result from these lesions. Our findings broaden the concept of neurodegenerative "synucleinopathies" by implicating betaS and gammaS, in addition to alphaS, in the onset/progression of PD and DLB.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
SNCAHumanLewy body dementia  IEP protein:increased expression:hippocampusRGD 
SNCBHumanLewy body dementia  IEP protein:increased expression:hippocampusRGD 
SNCGHumanLewy body dementia  IEP protein:increased expression:hippocampusRGD 
SncaRatLewy body dementia  ISOSNCA (Homo sapiens)protein:increased expression:hippocampusRGD 
SncaMouseLewy body dementia  ISOSNCA (Homo sapiens)protein:increased expression:hippocampusRGD 
SncbRatLewy body dementia  ISOSNCB (Homo sapiens)protein:increased expression:hippocampusRGD 
SncbMouseLewy body dementia  ISOSNCB (Homo sapiens)protein:increased expression:hippocampusRGD 
SncgRatLewy body dementia  ISOSNCG (Homo sapiens)protein:increased expression:hippocampusRGD 
SncgMouseLewy body dementia  ISOSNCG (Homo sapiens)protein:increased expression:hippocampusRGD 
SNCBHumanParkinson's disease  IEP protein:increased expression:hippocampusRGD 
SNCGHumanParkinson's disease  IEP protein:increased expression:hippocampusRGD 
SncbMouseParkinson's disease  ISOSNCB (Homo sapiens)protein:increased expression:hippocampusRGD 
SncbRatParkinson's disease  ISOSNCB (Homo sapiens)protein:increased expression:hippocampusRGD 
SncgRatParkinson's disease  ISOSNCG (Homo sapiens)protein:increased expression:hippocampusRGD 
SncgMouseParkinson's disease  ISOSNCG (Homo sapiens)protein:increased expression:hippocampusRGD 

Objects Annotated

Genes (Rattus norvegicus)
Snca  (synuclein alpha)
Sncb  (synuclein, beta)
Sncg  (synuclein, gamma)

Genes (Mus musculus)
Snca  (synuclein, alpha)
Sncb  (synuclein, beta)
Sncg  (synuclein, gamma)

Genes (Homo sapiens)
SNCA  (synuclein alpha)
SNCB  (synuclein beta)
SNCG  (synuclein gamma)


Additional Information