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Gene: Snca (synuclein, alpha) Mus musculus
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Symbol: Snca
Name: synuclein, alpha
RGD ID: 735748
Description: Exhibits arachidonic acid binding activity; histone binding activity; and identical protein binding activity. Involved in several processes, including chemical synaptic transmission; modulation of chemical synaptic transmission; and regulation of amine transport. Localizes to several cellular components, including inclusion body; neuronal cell body; and synaptic vesicle membrane. Predicted to colocalize with platelet alpha granule membrane. Is expressed in several structures, including brain; genitourinary system; liver; retina; and spleen. Used to study Parkinson's disease 1 and Parkinson's disease 4. Human ortholog(s) of this gene implicated in Alzheimer's disease; Lewy body dementia; Parkinson's disease; Parkinson's disease 1; and Parkinson's disease 4. Orthologous to human SNCA (synuclein alpha); PARTICIPATES IN Parkinson's disease pathway; Alzheimer's disease pathway; INTERACTS WITH (3,4-dihydroxyphenyl)acetic acid; (S)-amphetamine; 1,2-dimethylhydrazine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: al; alp; alpha SYN; alpha-Syn; alpha-synuclein; alphaSYN; NACP; non-A beta component of AD amyloid; non-A4 component of amyloid
Orthologs:
Homo sapiens (human) : SNCA (synuclein alpha)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Snca (synuclein alpha)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Snca (synuclein alpha)
Pan paniscus (bonobo/pygmy chimpanzee) : SNCA (synuclein alpha)
Canis lupus familiaris (dog) : SNCA (synuclein alpha)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Snca (synuclein alpha)
Sus scrofa (pig) : SNCA (synuclein alpha)
Chlorocebus sabaeus (African green monkey) : SNCA (synuclein alpha)
Heterocephalus glaber (naked mole-rat) : Snca (synuclein alpha)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39660,708,557 - 60,806,839 (-)NCBI
GRCm38660,731,573 - 60,829,855 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl660,731,575 - 60,829,855 (-)EnsemblGRCm38mm10GRCm38
MGSCv37660,681,567 - 60,779,849 (-)NCBIGRCm37mm9NCBIm37
MGSCv36660,661,161 - 60,759,433 (-)NCBImm8
Celera662,883,898 - 62,982,187 (-)NCBICelera
Cytogenetic Map6B3NCBI
cM Map629.15NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on Snca
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 735748
Created: 2004-02-06
Species: Mus musculus
Last Modified: 2020-11-17
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.