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Gene: Snca (synuclein, alpha) Mus musculus
Symbol: Snca
Name: synuclein, alpha
RGD ID: 735748
Description: Exhibits arachidonic acid binding activity; histone binding activity; and identical protein binding activity. Involved in several processes, including chemical synaptic transmission; modulation of chemical synaptic transmission; and regulation of amine transport. Localizes to several cellular components, including inclusion body; neuronal cell body; and synaptic vesicle membrane. Predicted to colocalize with platelet alpha granule membrane. Is expressed in several structures, including brain; genitourinary system; liver; retina; and spleen. Used to study Parkinson's disease 1 and Parkinson's disease 4. Human ortholog(s) of this gene implicated in Alzheimer's disease; Lewy body dementia; Parkinson's disease; Parkinson's disease 1; and Parkinson's disease 4. Orthologous to human SNCA (synuclein alpha); PARTICIPATES IN Parkinson's disease pathway; Alzheimer's disease pathway; INTERACTS WITH (3,4-dihydroxyphenyl)acetic acid; (S)-amphetamine; 1,2-dimethylhydrazine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: al; alp; alpha SYN; alpha-Syn; alpha-synuclein; alphaSYN; NACP; non-A beta component of AD amyloid; non-A4 component of amyloid
Homo sapiens (human) : SNCA (synuclein alpha)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Snca (synuclein alpha)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Snca (synuclein alpha)
Pan paniscus (bonobo/pygmy chimpanzee) : SNCA (synuclein alpha)
Canis lupus familiaris (dog) : SNCA (synuclein alpha)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Snca (synuclein alpha)
Sus scrofa (pig) : SNCA (synuclein alpha)
Chlorocebus sabaeus (African green monkey) : SNCA (synuclein alpha)
Heterocephalus glaber (naked mole-rat) : Snca (synuclein alpha)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm39660,708,557 - 60,806,839 (-)NCBI
GRCm38660,731,573 - 60,829,855 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl660,731,575 - 60,829,855 (-)EnsemblGRCm38mm10GRCm38
MGSCv37660,681,567 - 60,779,849 (-)NCBIGRCm37mm9NCBIm37
MGSCv36660,661,161 - 60,759,433 (-)NCBImm8
Celera662,883,898 - 62,982,187 (-)NCBICelera
Cytogenetic Map6B3NCBI
cM Map629.15NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Snca
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 735748
Created: 2004-02-06
Species: Mus musculus
Last Modified: 2020-11-17
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.