Snca (synuclein, alpha) - Rat Genome Database

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Gene: Snca (synuclein, alpha) Mus musculus
Analyze
Symbol: Snca
Name: synuclein, alpha
RGD ID: 735748
MGI Page MGI
Description: Enables arachidonic acid binding activity; histone binding activity; and identical protein binding activity. Involved in several processes, including positive regulation of peptidyl-serine phosphorylation; protein-containing complex assembly; and synaptic vesicle endocytosis. Acts upstream of or within several processes, including chemical synaptic transmission; modulation of chemical synaptic transmission; and regulation of amine transport. Located in several cellular components, including axon terminus; inclusion body; and neuronal cell body. Is active in synaptic vesicle membrane. Is expressed in several structures, including brain; genitourinary system; liver; retina; and spleen. Used to study Parkinson's disease 1 and Parkinson's disease 4. Human ortholog(s) of this gene implicated in Alzheimer's disease; Lewy body dementia; Parkinson's disease; Parkinson's disease 1; and Parkinson's disease 4. Orthologous to human SNCA (synuclein alpha).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: al; alp; alpha SYN; alpha-Syn; alpha-synuclein; alphaSYN; NACP; non-A beta component of AD amyloid; non-A4 component of amyloid
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39660,708,557 - 60,806,839 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl660,708,559 - 60,806,839 (-)EnsemblGRCm39 Ensembl
GRCm38660,731,573 - 60,829,855 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl660,731,575 - 60,829,855 (-)EnsemblGRCm38mm10GRCm38
MGSCv37660,681,567 - 60,779,849 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36660,661,161 - 60,759,433 (-)NCBIMGSCv36mm8
Celera662,883,898 - 62,982,187 (-)NCBICelera
Cytogenetic Map6B3NCBI
cM Map629.15NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-selegiline  (ISO)
(25R)-cholest-5-ene-3beta,26-diol  (ISO)
(3,4-dihydroxyphenyl)acetic acid  (EXP)
(R)-lipoic acid  (ISO)
(R,R,R)-alpha-tocopherol  (ISO)
(RS)-1-benzyl-1,2,3,4-tetrahydroisoquinoline  (ISO)
(S)-amphetamine  (EXP)
(S)-nicotine  (ISO)
1,2-dimethylhydrazine  (EXP)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (EXP,ISO)
1-nitropyrene  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (EXP)
2-butoxyethanol  (EXP)
2-hydroxypropanoic acid  (ISO)
2-methylcholine  (ISO)
2-naphthylamine  (ISO)
26-hydroxycholesterol  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3-hydroxybutyric acid  (ISO)
3-methyladenine  (ISO)
3-phenylprop-2-enal  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (EXP)
4-phenylbutyric acid  (EXP)
5,6,7,8-tetrahydrobiopterin  (ISO)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (ISO)
8-Br-cAMP  (ISO)
acetamide  (ISO)
acetylsalicylic acid  (EXP)
acrolein  (ISO)
actinomycin D  (ISO)
alcohol  (ISO)
all-trans-retinoic acid  (ISO)
all-trans-retinol  (ISO)
aluminium atom  (ISO)
aluminium(0)  (ISO)
ammonium chloride  (ISO)
anthocyanin  (ISO)
antimycin A  (ISO)
antirheumatic drug  (ISO)
apigenin  (ISO)
apocynin  (ISO)
aristolochic acid  (ISO)
Aroclor 1254  (ISO)
arsane  (EXP,ISO)
arsenic acid  (ISO)
arsenic atom  (EXP,ISO)
arsenite(3-)  (EXP,ISO)
arsenous acid  (ISO)
ATP  (ISO)
atrazine  (ISO)
azoxystrobin  (ISO)
bafilomycin A1  (EXP)
baicalein  (EXP,ISO)
BAPTA  (ISO)
benzo[a]pyrene  (EXP,ISO)
beta-naphthoflavone  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bortezomib  (ISO)
buta-1,3-diene  (EXP)
butanal  (ISO)
cadmium dichloride  (EXP)
calcium atom  (ISO)
calcium(0)  (ISO)
Calpeptin  (ISO)
carbon nanotube  (EXP)
CGP 52608  (ISO)
chlorpyrifos  (EXP,ISO)
cis-caffeic acid  (ISO)
cisplatin  (ISO)
cobalt dichloride  (ISO)
cocaine  (ISO)
coenzyme Q10  (EXP,ISO)
conduritol B epoxide  (EXP,ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) chloride  (ISO)
Corynoxine B  (ISO)
creatine  (EXP)
curcumin  (EXP)
cyclosporin A  (EXP,ISO)
cypermethrin  (ISO)
cytarabine  (ISO)
dabigatran  (ISO)
deguelin  (ISO)
diarsenic trioxide  (ISO)
dibenz[a,h]anthracene  (EXP)
dibenziodolium  (EXP)
dibutyl phthalate  (EXP)
dichloroacetic acid  (EXP)
dichlorvos  (ISO)
diclofenac  (EXP)
dieldrin  (EXP,ISO)
diethyldithiocarbamic acid  (ISO)
diethylstilbestrol  (ISO)
dimethylarsinic acid  (ISO)
dioxygen  (EXP)
dopamine  (EXP,ISO)
dopaminechrome (enol form)  (ISO)
dorsomorphin  (ISO)
doxorubicin  (EXP)
echinacoside  (ISO)
empagliflozin  (ISO)
entacapone  (ISO)
entinostat  (ISO)
ethanol  (EXP,ISO)
fasudil  (ISO)
fenpyroximate  (ISO)
flavonoids  (ISO)
folic acid  (EXP)
fulvestrant  (ISO)
gallic acid  (ISO)
gamma-tocopherol  (EXP)
geraniol  (EXP,ISO)
glutathione  (ISO)
glutathione disulfide  (ISO)
glyburide  (EXP)
glyphosate  (ISO)
GTP  (ISO)
GW 3965  (ISO)
heptanal  (ISO)
hexanal  (ISO)
hydrogen peroxide  (ISO)
hydroxyurea  (ISO)
iron atom  (EXP,ISO)
iron dichloride  (ISO)
iron(0)  (EXP,ISO)
iron(2+) sulfate (anhydrous)  (ISO)
ivermectin  (ISO)
L-ascorbic acid  (EXP)
lactacystin  (ISO)
lead diacetate  (ISO)
lead nitrate  (EXP)
lead(0)  (ISO)
lead(2+)  (ISO)
linsidomine  (ISO)
lipoic acid  (ISO)
lipopolysaccharide  (EXP)
lithium atom  (ISO)
lithium chloride  (ISO)
lithium hydride  (ISO)
maneb  (EXP,ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
melatonin  (EXP,ISO)
mercury dibromide  (ISO)
methamphetamine  (EXP,ISO)
methylmercury chloride  (EXP)
microcystin  (ISO)
morphine  (ISO)
N-acetyl-L-cysteine  (ISO)
N-methyl-4-phenylpyridinium  (EXP,ISO)
nickel atom  (ISO)
nickel sulfate  (ISO)
nicotine  (ISO)
nicotinic acid  (EXP)
nitric oxide  (ISO)
nonanal  (ISO)
O-acetyl-L-carnitine  (ISO)
octanal  (ISO)
omega-conotoxin GVIA  (ISO)
oxidopamine  (ISO)
ozone  (EXP)
paracetamol  (EXP)
paraquat  (EXP,ISO)
PCB138  (ISO)
pentanal  (ISO)
permethrin  (EXP,ISO)
phenobarbital  (EXP)
potassium dichromate  (EXP)
proanthocyanidin  (ISO)
probucol  (ISO)
propanal  (ISO)
propionic acid  (ISO)
pyridaben  (ISO)
pyrogallol  (ISO)
quercetin  (ISO)
rac-lactic acid  (ISO)
raloxifene  (ISO)
reactive nitrogen species  (ISO)
reactive oxygen species  (ISO)
reserpine  (EXP)
resveratrol  (ISO)
rifampicin  (ISO)
rotenone  (EXP,ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (ISO)
sapropterin  (ISO)
sarin  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
silver atom  (EXP)
silver(0)  (EXP)
sirolimus  (ISO)
sirtinol  (ISO)
SKF 38393  (ISO)
sodium arsenite  (EXP,ISO)
staurosporine  (ISO)
stigmatellin A  (ISO)
tacrine  (ISO)
tamoxifen  (ISO)
taurine  (EXP)
tauroursodeoxycholic acid  (ISO)
telmisartan  (EXP)
temozolomide  (ISO)
testosterone  (ISO)
testosterone enanthate  (ISO)
tetrachloromethane  (ISO)
titanium dioxide  (EXP)
tocopherol  (EXP)
tolcapone  (ISO)
topotecan  (ISO)
trans-caffeic acid  (ISO)
Tributyltin oxide  (EXP)
trichloroethene  (ISO)
trichostatin A  (ISO)
tungsten  (EXP)
valproic acid  (ISO)
ziram  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activation of cysteine-type endopeptidase activity involved in apoptotic process  (ISO)
adult locomotory behavior  (IGI)
aging  (ISO)
amyloid fibril formation  (ISO)
behavioral response to cocaine  (ISO)
calcium ion homeostasis  (ISO)
cellular response to copper ion  (ISO)
cellular response to fibroblast growth factor stimulus  (ISO)
cellular response to oxidative stress  (IMP)
chemical synaptic transmission  (IBA,IGI)
dopamine biosynthetic process  (IMP)
dopamine metabolic process  (IGI)
excitatory postsynaptic potential  (IMP)
fatty acid metabolic process  (IMP)
localization  (ISO)
long-term synaptic potentiation  (IMP)
membrane organization  (IMP)
microglial cell activation  (IMP)
mitochondrial ATP synthesis coupled electron transport  (IMP)
mitochondrial membrane organization  (IMP)
negative regulation of apoptotic process  (ISO)
negative regulation of chaperone-mediated autophagy  (ISO)
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process  (ISO)
negative regulation of dopamine metabolic process  (ISO)
negative regulation of dopamine uptake involved in synaptic transmission  (ISO)
negative regulation of exocytosis  (ISO)
negative regulation of histone acetylation  (ISO)
negative regulation of microtubule polymerization  (ISO)
negative regulation of monooxygenase activity  (ISO)
negative regulation of neuron apoptotic process  (IGI,ISO)
negative regulation of neuron death  (ISO)
negative regulation of norepinephrine uptake  (ISO)
negative regulation of platelet-derived growth factor receptor signaling pathway  (ISO)
negative regulation of protein phosphorylation  (ISO)
negative regulation of serotonin uptake  (ISO)
negative regulation of thrombin-activated receptor signaling pathway  (ISO)
negative regulation of transporter activity  (ISO)
neuron apoptotic process  (IGI,IMP)
neurotransmitter secretion  (IDA)
neutral lipid metabolic process  (IMP)
phospholipid metabolic process  (IMP)
positive regulation of endocytosis  (ISO)
positive regulation of exocytosis  (ISO)
positive regulation of glutathione peroxidase activity  (ISO)
positive regulation of hydrogen peroxide catabolic process  (ISO)
positive regulation of inflammatory response  (ISO)
positive regulation of inositol phosphate biosynthetic process  (ISO)
positive regulation of neuron death  (ISO)
positive regulation of neurotransmitter secretion  (IDA)
positive regulation of peptidyl-serine phosphorylation  (IMP)
positive regulation of protein serine/threonine kinase activity  (ISO)
positive regulation of receptor recycling  (ISO)
positive regulation of release of sequestered calcium ion into cytosol  (ISO)
positive regulation of SNARE complex assembly  (ISO)
positive regulation of synaptic transmission  (IMP)
protein complex oligomerization  (IDA)
protein destabilization  (ISO)
protein tetramerization  (ISO)
receptor internalization  (ISO)
regulation of acyl-CoA biosynthetic process  (IDA,IMP)
regulation of dopamine secretion  (IGI,TAS)
regulation of glutamate secretion  (IMP)
regulation of locomotion  (IMP)
regulation of long-term neuronal synaptic plasticity  (IMP)
regulation of macrophage activation  (IMP)
regulation of neuron apoptotic process  (IMP)
regulation of neuron death  (IBA,ISO)
regulation of neuronal synaptic plasticity  (IMP)
regulation of neurotransmitter secretion  (IGI,IMP)
regulation of norepinephrine uptake  (ISO)
regulation of phospholipase activity  (ISO)
regulation of presynapse assembly  (ISO)
regulation of reactive oxygen species metabolic process  (IMP)
regulation of transmembrane transporter activity  (ISO)
response to cocaine  (ISO)
response to desipramine  (ISO)
response to interleukin-1  (ISO)
response to iron(II) ion  (ISO)
response to lipopolysaccharide  (ISO)
response to magnesium ion  (ISO)
response to type II interferon  (ISO)
response to xenobiotic stimulus  (IMP)
SNARE complex assembly  (IDA,ISO)
synapse organization  (IBA,IGI)
synaptic transmission, dopaminergic  (IMP)
synaptic vesicle endocytosis  (IBA,IDA,IMP)
synaptic vesicle exocytosis  (ISO)
synaptic vesicle priming  (ISO)
synaptic vesicle transport  (IMP)

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal axon morphology  (IAGP)
abnormal digestive system physiology  (IAGP)
abnormal dopaminergic neuron morphology  (IAGP)
abnormal gait  (IAGP)
abnormal hippocampus morphology  (IAGP)
abnormal intestinal transit time  (IAGP)
abnormal large intestinal transit time  (IAGP)
abnormal locomotor activation  (IAGP)
abnormal locomotor behavior  (IEA)
abnormal lysosome morphology  (IAGP)
abnormal male preputial gland morphology  (IAGP)
abnormal miniature excitatory postsynaptic currents  (IAGP)
abnormal motor capabilities/coordination/movement  (IAGP)
abnormal nervous system physiology  (IAGP)
abnormal neuron physiology  (IAGP)
abnormal posture  (IAGP)
abnormal reflex  (IAGP)
abnormal respiratory electron transport chain  (IAGP)
abnormal response to infection  (IAGP)
abnormal spinal cord ventral horn morphology  (IAGP)
abnormal spinal nerve morphology  (IAGP)
abnormal striatum morphology  (IAGP)
abnormal synaptic dopamine release  (IAGP)
abnormal synaptic transmission  (IAGP)
abnormal ventral spinal root morphology  (IAGP)
alpha-synuclein inclusion body  (IAGP)
astrocytosis  (IAGP)
axon degeneration  (IAGP)
catalepsy  (IAGP)
constipation  (IAGP)
decreased body weight  (IAGP)
decreased dopamine level  (IAGP)
decreased dopaminergic neuron number  (IAGP)
decreased locomotor activity  (IAGP)
decreased physiological sensitivity to xenobiotic  (IAGP)
decreased susceptibility to bacterial infection  (IAGP)
decreased susceptibility to dopaminergic neuron neurotoxicity  (IAGP)
gliosis  (IAGP)
impaired coordination  (IAGP)
increased circulating amylase level  (IEA)
increased circulating creatinine level  (IEA)
increased dopamine level  (IAGP)
increased fasting circulating glucose level  (IEA)
increased locomotor activity  (IAGP)
increased mean platelet volume  (IEA)
increased physiological sensitivity to xenobiotic  (IAGP)
increased susceptibility to bacterial infection  (IAGP)
kyphosis  (IAGP)
long stride length  (IAGP)
loss of dopaminergic neurons  (IAGP)
neurodegeneration  (IAGP)
neuron degeneration  (IAGP)
neuronal intranuclear inclusions  (IAGP)
no abnormal phenotype detected  (IEA)
premature death  (IAGP)
prolonged PR interval  (IEA)
reduced long term potentiation  (IAGP)
short stride length  (IAGP)
slow postnatal weight gain  (IAGP)
weakness  (IAGP)
weight loss  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. Mice lacking alpha-synuclein display functional deficits in the nigrostriatal dopamine system. Abeliovich A, etal., Neuron 2000 Jan;25(1):239-52.
2. Genes associated with Parkinson's disease: regulation of autophagy and beyond. Beilina A and Cookson MR, J Neurochem. 2015 Jul 30. doi: 10.1111/jnc.13266.
3. Alphalpha-Synuclein as a Mediator in the Interplay between Aging and Parkinson's Disease. Bobela W, etal., Biomolecules. 2015 Oct 16;5(4):2675-700. doi: 10.3390/biom5042675.
4. Neurodegeneration with brain iron accumulation, type 1 is characterized by alpha-, beta-, and gamma-synuclein neuropathology. Galvin JE, etal., Am J Pathol. 2000 Aug;157(2):361-8.
5. Axon pathology in Parkinson's disease and Lewy body dementia hippocampus contains alpha-, beta-, and gamma-synuclein. Galvin JE, etal., Proc Natl Acad Sci U S A. 1999 Nov 9;96(23):13450-5.
6. In vivo RNAi-mediated alpha-synuclein silencing induces nigrostriatal degeneration. Gorbatyuk OS, etal., Mol Ther. 2010 Aug;18(8):1450-7. doi: 10.1038/mt.2010.115. Epub 2010 Jun 15.
7. The phosphorylation state of Ser-129 in human alpha-synuclein determines neurodegeneration in a rat model of Parkinson disease. Gorbatyuk OS, etal., Proc Natl Acad Sci U S A. 2008 Jan 15;105(2):763-8. doi: 10.1073/pnas.0711053105. Epub 2008 Jan 4.
8. Impaired intracellular trafficking defines early Parkinson's disease. Hunn BH, etal., Trends Neurosci. 2015 Mar;38(3):178-88. doi: 10.1016/j.tins.2014.12.009. Epub 2015 Jan 29.
9. Desipramine modulation of alpha-, gamma-synuclein, and the norepinephrine transporter in an animal model of depression. Jeannotte AM, etal., Neuropsychopharmacology. 2009 Mar;34(4):987-98. Epub 2008 Sep 17.
10. Lewy body/alpha-synucleinopathy in schizophrenia and depression: a preliminary neuropathological study. Jellinger KA Acta Neuropathol. 2009 Apr;117(4):423-7. Epub 2009 Feb 6.
11. Selective insolubility of alpha-synuclein in human Lewy body diseases is recapitulated in a transgenic mouse model. Kahle PJ, etal., Am J Pathol. 2001 Dec;159(6):2215-25.
12. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
13. Ala30Pro mutation in the gene encoding alpha-synuclein in Parkinson's disease. Kruger R, etal., Nat Genet. 1998 Feb;18(2):106-8.
14. Endogenous alpha-synuclein is induced by valproic acid through histone deacetylase inhibition and participates in neuroprotection against glutamate-induced excitotoxicity. Leng Y and Chuang DM, J Neurosci. 2006 Jul 12;26(28):7502-12. doi: 10.1523/JNEUROSCI.0096-06.2006.
15. Traumatic brain injury dysregulates microRNAs to modulate cell signaling in rat hippocampus. Liu L, etal., PLoS One. 2014 Aug 4;9(8):e103948. doi: 10.1371/journal.pone.0103948. eCollection 2014.
16. Alpha- and beta-synucleins are new diagnostic tools for acute erythroid leukemia and acute megakaryoblastic leukemia. Maitta RW, etal., Am J Hematol. 2011 Feb;86(2):230-4. doi: 10.1002/ajh.21932.
17. Cocaine abusers have an overexpression of alpha-synuclein in dopamine neurons. Mash DC, etal., J Neurosci. 2003 Apr 1;23(7):2564-71.
18. beta-amyloid peptides enhance alpha-synuclein accumulation and neuronal deficits in a transgenic mouse model linking Alzheimer's disease and Parkinson's disease. Masliah E, etal., Proc Natl Acad Sci U S A 2001 Oct 9;98(21):12245-50. Epub 2001 Sep 25.
19. Dopaminergic loss and inclusion body formation in alpha-synuclein mice: implications for neurodegenerative disorders. Masliah E, etal., Science 2000 Feb 18;287(5456):1265-9.
20. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
21. MGDs mouse GO annotations MGD data from the GO Consortium
22. MGD IEA MGD IEA
23. Direct quantification of CSF alpha-synuclein by ELISA and first cross-sectional study in patients with neurodegeneration. Mollenhauer B, etal., Exp Neurol. 2008 Oct;213(2):315-25. doi: 10.1016/j.expneurol.2008.06.004. Epub 2008 Jun 14.
24. Alpha-synuclein immunoreactivity in normal and neoplastic Schwann cells. Mori F, etal., Acta Neuropathol. 2002 Feb;103(2):145-51. Epub 2001 Oct 18.
25. Pick's disease: alpha- and beta-synuclein-immunoreactive Pick bodies in the dentate gyrus. Mori F, etal., Acta Neuropathol. 2002 Nov;104(5):455-61. Epub 2002 Jul 2.
26. Alpha- and gamma-synuclein proteins are present in cerebrospinal fluid and are increased in aged subjects with neurodegenerative and vascular changes. Mukaetova-Ladinska EB, etal., Dement Geriatr Cogn Disord. 2008;26(1):32-42. Epub 2008 Jun 25.
27. Association of alpha-, beta-, and gamma-Synuclein with diffuse lewy body disease. Nishioka K, etal., Arch Neurol. 2010 Aug;67(8):970-5.
28. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
29. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
30. Autoantibodies to alpha-synuclein in inherited Parkinson's disease. Papachroni KK, etal., J Neurochem. 2007 May;101(3):749-56.
31. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
32. Mutation in the alpha-synuclein gene identified in families with Parkinson's disease. Polymeropoulos MH, etal., Science. 1997 Jun 27;276(5321):2045-7.
33. Mouse MP Annotation Import Pipeline RGD automated import pipeline
34. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
35. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
36. Developmental loss and resistance to MPTP toxicity of dopaminergic neurones in substantia nigra pars compacta of gamma-synuclein, alpha-synuclein and double alpha/gamma-synuclein null mutant mice. Robertson DC, etal., J Neurochem. 2004 Jun;89(5):1126-36.
37. Neuronal accumulation of alpha- and beta-synucleins in the brain of a GM2 gangliosidosis mouse model. Suzuki K, etal., Neuroreport. 2003 Mar 24;14(4):551-4.
38. Glial cytoplasmic inclusions in white matter oligodendrocytes of multiple system atrophy brains contain insoluble alpha-synuclein. Tu PH, etal., Ann Neurol. 1998 Sep;44(3):415-22.
39. Age-dependent synuclein pathology following traumatic brain injury in mice. Uryu K, etal., Exp Neurol. 2003 Nov;184(1):214-24.
40. NACP/alpha-synuclein-positive filamentous inclusions in astrocytes and oligodendrocytes of Parkinson's disease brains. Wakabayashi K, etal., Acta Neuropathol. 2000 Jan;99(1):14-20.
41. Selective alterations of gene expression in mice induced by MPTP. Xu Z, etal., Synapse. 2005 Jan;55(1):45-51.
Additional References at PubMed
PMID:9601701   PMID:9648883   PMID:9750188   PMID:10349636   PMID:10786830   PMID:10799001   PMID:10964942   PMID:10978144   PMID:11042159   PMID:11076861   PMID:11113617   PMID:11156617  
PMID:11312297   PMID:11359883   PMID:11442360   PMID:11591219   PMID:11687285   PMID:11790792   PMID:11926821   PMID:12009758   PMID:12062037   PMID:12151792   PMID:12376616   PMID:12388586  
PMID:12438441   PMID:12477932   PMID:12495618   PMID:12498958   PMID:12534964   PMID:12732244   PMID:12819014   PMID:12819125   PMID:12928483   PMID:14507911   PMID:14550771   PMID:14572463  
PMID:14585981   PMID:14672949   PMID:14973278   PMID:15033420   PMID:15177571   PMID:15288507   PMID:15304353   PMID:15322100   PMID:15380020   PMID:15465911   PMID:15466467   PMID:15489334  
PMID:15510220   PMID:15579163   PMID:15585343   PMID:15590933   PMID:15639180   PMID:15655262   PMID:15684072   PMID:15743798   PMID:15765523   PMID:15782199   PMID:15784963   PMID:15797547  
PMID:15840579   PMID:15938614   PMID:16006012   PMID:16030137   PMID:16037097   PMID:16096643   PMID:16112475   PMID:16141072   PMID:16141073   PMID:16242637   PMID:16260631   PMID:16269331  
PMID:16291942   PMID:16298531   PMID:16412098   PMID:16480958   PMID:16597723   PMID:16602821   PMID:16611810   PMID:16636270   PMID:16734431   PMID:16837852   PMID:16872721   PMID:16959795  
PMID:16981894   PMID:17018883   PMID:17028574   PMID:17035541   PMID:17077307   PMID:17088319   PMID:17108165   PMID:17222866   PMID:17227870   PMID:17250657   PMID:17250686   PMID:17296554  
PMID:17444492   PMID:17475220   PMID:17592014   PMID:17610578   PMID:17689254   PMID:17708336   PMID:17853477   PMID:17949715   PMID:18036154   PMID:18053987   PMID:18172548   PMID:18226447  
PMID:18297066   PMID:18333965   PMID:18369389   PMID:18423664   PMID:18456291   PMID:18566453   PMID:18614564   PMID:18622040   PMID:18650345   PMID:18665422   PMID:18702517   PMID:18769546  
PMID:18782562   PMID:18790059   PMID:18980610   PMID:18992718   PMID:19004816   PMID:19012742   PMID:19021916   PMID:19097673   PMID:19135032   PMID:19142237   PMID:19203374   PMID:19228951  
PMID:19272424   PMID:19286568   PMID:19361478   PMID:19409267   PMID:19409883   PMID:19457104   PMID:19457162   PMID:19542206   PMID:19553474   PMID:19554387   PMID:19627450   PMID:19651612  
PMID:19680561   PMID:19744960   PMID:19800328   PMID:19879926   PMID:19885730   PMID:20053987   PMID:20056137   PMID:20064389   PMID:20071342   PMID:20079841   PMID:20106867   PMID:20106983  
PMID:20138333   PMID:20138921   PMID:20152114   PMID:20200163   PMID:20203200   PMID:20224454   PMID:20356833   PMID:20374434   PMID:20420875   PMID:20457918   PMID:20485674   PMID:20524960  
PMID:20550572   PMID:20624443   PMID:20628651   PMID:20638384   PMID:20640532   PMID:20711648   PMID:20733075   PMID:20798282   PMID:20855506   PMID:20858756   PMID:20877387   PMID:20974939  
PMID:21029764   PMID:21045828   PMID:21048992   PMID:21055449   PMID:21091473   PMID:21108729   PMID:21124898   PMID:21127069   PMID:21151134   PMID:21245577   PMID:21255620   PMID:21267068  
PMID:21272100   PMID:21276428   PMID:21296890   PMID:21423666   PMID:21445308   PMID:21489994   PMID:21554732   PMID:21559417   PMID:21563316   PMID:21593311   PMID:21658411   PMID:21684039  
PMID:21693152   PMID:21699982   PMID:21721555   PMID:21734300   PMID:21736378   PMID:21779395   PMID:21801874   PMID:21812967   PMID:21832061   PMID:21840348   PMID:21846727   PMID:21873635  
PMID:21905125   PMID:21953697   PMID:21966373   PMID:21982369   PMID:21990355   PMID:21995845   PMID:22000591   PMID:22033456   PMID:22045698   PMID:22112368   PMID:22142176   PMID:22163275  
PMID:22188655   PMID:22232689   PMID:22315227   PMID:22344407   PMID:22355774   PMID:22371502   PMID:22469626   PMID:22473712   PMID:22508489   PMID:22508839   PMID:22537068   PMID:22705949  
PMID:22719003   PMID:22748019   PMID:22776201   PMID:22779732   PMID:22815513   PMID:22836248   PMID:22883907   PMID:22905247   PMID:22936601   PMID:22944910   PMID:23011138   PMID:23013868  
PMID:23077667   PMID:23100443   PMID:23124190   PMID:23129765   PMID:23161999   PMID:23175842   PMID:23183827   PMID:23209687   PMID:23219665   PMID:23342162   PMID:23344955   PMID:23345080  
PMID:23349488   PMID:23382946   PMID:23393156   PMID:23399889   PMID:23466394   PMID:23560093   PMID:23626796   PMID:23638301   PMID:23643841   PMID:23667637   PMID:23792198   PMID:23933574  
PMID:24036317   PMID:24046356   PMID:24048740   PMID:24058406   PMID:24058647   PMID:24076025   PMID:24082145   PMID:24117685   PMID:24121116   PMID:24236103   PMID:24239384   PMID:24252179  
PMID:24325796   PMID:24381286   PMID:24382629   PMID:24386307   PMID:24388731   PMID:24402137   PMID:24412932   PMID:24415155   PMID:24486885   PMID:24619358   PMID:24691202   PMID:24746855  
PMID:24810045   PMID:24865427   PMID:24866403   PMID:24867427   PMID:24898419   PMID:24905915   PMID:24952961   PMID:24983211   PMID:24995537   PMID:25002524   PMID:25009269   PMID:25009275  
PMID:25028513   PMID:25037286   PMID:25043722   PMID:25051958   PMID:25058424   PMID:25076905   PMID:25092570   PMID:25095794   PMID:25112678   PMID:25124556   PMID:25195598   PMID:25209277  
PMID:25246573   PMID:25264250   PMID:25278492   PMID:25296918   PMID:25297088   PMID:25298402   PMID:25316793   PMID:25319443   PMID:25351739   PMID:25387690   PMID:25394490   PMID:25428949  
PMID:25471588   PMID:25484190   PMID:25556793   PMID:25778619   PMID:25825709   PMID:25834048   PMID:25855184   PMID:25917213   PMID:25952542   PMID:25961568   PMID:25967550   PMID:25969543  
PMID:25997379   PMID:26076669   PMID:26099047   PMID:26170293   PMID:26181201   PMID:26203154   PMID:26317866   PMID:26324905   PMID:26358191   PMID:26378614   PMID:26451483   PMID:26564109  
PMID:26643113   PMID:26663874   PMID:26689812   PMID:26719256   PMID:26758845   PMID:26833254   PMID:26839406   PMID:27001837   PMID:27021360   PMID:27339877   PMID:27343690   PMID:27348587  
PMID:27358461   PMID:27378017   PMID:27378698   PMID:27382062   PMID:27407143   PMID:27425033   PMID:27466341   PMID:27565429   PMID:27614017   PMID:27653697   PMID:27708076   PMID:27733604  
PMID:27742469   PMID:27779468   PMID:27838898   PMID:27864010   PMID:27881461   PMID:27903237   PMID:27904950   PMID:28039592   PMID:28049716   PMID:28052246   PMID:28068606   PMID:28117497  
PMID:28148299   PMID:28257421   PMID:28266709   PMID:28288128   PMID:28351932   PMID:28362802   PMID:28396396   PMID:28462393   PMID:28533388   PMID:28576704   PMID:28611062   PMID:28648742  
PMID:28797124   PMID:28855681   PMID:28910367   PMID:28923922   PMID:28933786   PMID:28993630   PMID:29154191   PMID:29166608   PMID:29209768   PMID:29217686   PMID:29243900   PMID:29244999  
PMID:29246723   PMID:29272304   PMID:29310663   PMID:29355568   PMID:29367610   PMID:29483518   PMID:29497361   PMID:29502200   PMID:29547959   PMID:29670081   PMID:29678776   PMID:29718367  
PMID:29743672   PMID:29759483   PMID:29769405   PMID:29863470   PMID:29865270   PMID:29897434   PMID:29899409   PMID:29966750   PMID:29976670   PMID:29995210   PMID:30046897   PMID:30080657  
PMID:30092270   PMID:30096435   PMID:30116778   PMID:30120834   PMID:30150626   PMID:30195626   PMID:30219847   PMID:30249789   PMID:30253092   PMID:30260025   PMID:30308173   PMID:30381407  
PMID:30503521   PMID:30509990   PMID:30528390   PMID:30538177   PMID:30543522   PMID:30562941   PMID:30599154   PMID:30790619   PMID:30796692   PMID:30796974   PMID:30846695   PMID:30862700  
PMID:30877431   PMID:30901378   PMID:30907009   PMID:30983487   PMID:31033038   PMID:31036561   PMID:31036761   PMID:31041657   PMID:31092553   PMID:31167929   PMID:31255487   PMID:31267130  
PMID:31277379   PMID:31312839   PMID:31315048   PMID:31346295   PMID:31358653   PMID:31358782   PMID:31370680   PMID:31419995   PMID:31505254   PMID:31509576   PMID:31520492   PMID:31617346  
PMID:31644913   PMID:31683259   PMID:31705886   PMID:31722091   PMID:31754648   PMID:31785806   PMID:31837424   PMID:31850343   PMID:31856640   PMID:31899072   PMID:31912891   PMID:32017806  
PMID:32207050   PMID:32224067   PMID:32325033   PMID:32327648   PMID:32356558   PMID:32391886   PMID:32393371   PMID:32417536   PMID:32560668   PMID:32641150   PMID:32697196   PMID:32788297  
PMID:32817196   PMID:32819195   PMID:32868762   PMID:32943057   PMID:32996158   PMID:32997293   PMID:33000527   PMID:33009395   PMID:33083886   PMID:33091110   PMID:33188884   PMID:33235246  
PMID:33273122   PMID:33316306   PMID:33428941   PMID:33497415   PMID:33556113   PMID:33563726   PMID:33632316   PMID:33692101   PMID:33751935   PMID:33805843   PMID:33875010   PMID:33974284  
PMID:34061533   PMID:34062940   PMID:34083630   PMID:34148543   PMID:34321069   PMID:34326260   PMID:34359864   PMID:34360942   PMID:34380535   PMID:34393754   PMID:34462307   PMID:34502283  
PMID:34508096   PMID:34555357   PMID:34572500   PMID:34590209   PMID:34749824   PMID:35021075   PMID:35085893   PMID:35089485   PMID:35092321   PMID:35172141   PMID:35182691   PMID:35250825  
PMID:35417693   PMID:35420219   PMID:35599331   PMID:35659303   PMID:35750147   PMID:35955451   PMID:35964686   PMID:36009004  


Genomics

Comparative Map Data
Snca
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39660,708,557 - 60,806,839 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl660,708,559 - 60,806,839 (-)EnsemblGRCm39 Ensembl
GRCm38660,731,573 - 60,829,855 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl660,731,575 - 60,829,855 (-)EnsemblGRCm38mm10GRCm38
MGSCv37660,681,567 - 60,779,849 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36660,661,161 - 60,759,433 (-)NCBIMGSCv36mm8
Celera662,883,898 - 62,982,187 (-)NCBICelera
Cytogenetic Map6B3NCBI
cM Map629.15NCBI
SNCA
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38489,724,099 - 89,838,304 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl489,700,345 - 89,838,315 (-)EnsemblGRCh38hg38GRCh38
GRCh37490,645,250 - 90,759,455 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36490,865,728 - 90,977,156 (-)NCBINCBI36Build 36hg18NCBI36
Build 34491,004,212 - 91,114,009NCBI
Celera487,942,196 - 88,056,576 (-)NCBICelera
Cytogenetic Map4q22.1NCBI
HuRef486,396,384 - 86,510,518 (-)NCBIHuRef
CHM1_1490,621,712 - 90,735,909 (-)NCBICHM1_1
T2T-CHM13v2.0493,055,378 - 93,169,553 (-)NCBIT2T-CHM13v2.0
Snca
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2489,696,420 - 89,797,240 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl489,696,420 - 89,796,262 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx494,908,873 - 95,008,815 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0490,684,174 - 90,784,124 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0489,081,018 - 89,195,868 (-)NCBIRnor_WKY
Rnor_6.0490,782,412 - 90,883,236 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl490,782,374 - 90,882,285 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04155,592,411 - 155,690,724 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4489,613,731 - 89,722,807 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1489,858,155 - 89,967,232 (-)NCBI
Celera484,478,545 - 84,578,894 (-)NCBICelera
Cytogenetic Map4q24NCBI
Snca
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955405853,946 - 965,403 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955405854,011 - 962,741 (-)NCBIChiLan1.0ChiLan1.0
SNCA
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1492,737,608 - 92,851,720 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl492,737,608 - 92,850,600 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0482,018,585 - 82,132,938 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
SNCA
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13212,915,871 - 13,079,338 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3212,916,215 - 13,060,383 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3228,876,711 - 29,040,565 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03212,968,680 - 13,133,813 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3212,966,388 - 13,113,867 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13213,053,952 - 13,218,226 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03212,876,233 - 13,041,037 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03226,872,693 - 27,039,258 (+)NCBIUU_Cfam_GSD_1.0
Snca
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530128,380,373 - 28,478,711 (+)NCBIHiC_Itri_2
SpeTri2.0NW_0049366852,077,017 - 2,175,298 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SNCA
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl8129,248,819 - 129,271,128 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.18129,247,724 - 129,388,307 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.28138,635,406 - 138,774,240 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SNCA
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1738,083,154 - 38,194,068 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl738,081,509 - 38,191,479 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603716,869,729 - 16,980,841 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Snca
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475717,392,998 - 17,528,320 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475717,393,046 - 17,528,783 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:336
Count of miRNA genes:146
Interacting mature miRNAs:168
Transcripts:ENSMUST00000114268, ENSMUST00000163779
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
25440480Moaq2_mmodifier of alien QTL 2 (mouse)63050001117476961Mouse
26884414Bzwq12_mbi-zygomatic width QTL 12, 16 week (mouse)63400000139076998Mouse
1300556Cia6_mcollagen induced arthritis QTL 6 (mouse)Not determined6446488487403016Mouse
4142271Egq8_mearly growth QTL 8 (mouse)Not determined450382396633110Mouse
4142232W6q4_mweight 6 weeks QTL 4 (mouse)Not determined450382396633110Mouse
4142126W3q3_mweight 3 weeks QTL 3 (mouse)Not determined450382396633110Mouse
4142361W10q11_mweight 10 weeks QTL 11 (mouse)Not determined450382396633110Mouse
26884441Sklq3_mskull length QTL 3, 5 week (mouse)6760000080576983Mouse
1357442Dbts1_mdiabetes 1 (mouse)Not determined61823414773364675Mouse
10412213Sxbq2_mSGC/Knj cross B6 QTL 2 (mouse)Not determined61991268571299759Mouse
13208564Bmiq7_mbody mass index QTL 7 (mouse)62499999979976983Mouse
4141988Obrq3_mobesity resistance QTL 3 (mouse)Not determined2829099362291115Mouse
4141454Obrq4_mobesity resistance QTL 4 (mouse)Not determined3170349965703611Mouse
12880425V25Dq5_mvitamin D inactive form serum level QTL 5 (mouse)63267698066676980Mouse
4141782Mrdq5_mmodifier of retinal degeneration QTL 5 (mouse)Not determined3282758578215957Mouse
1300959Lxw2_mlupus BXSB x NZW 2 (mouse)Not determined63387226167872400Mouse
11252142Mom12_mModifier of Min 12 (mouse)63387226167872400Mouse
1300767Aliq4_macute lung injury QTL 4 (mouse)Not determined63627333270273435Mouse
1357539Bsbob3_mBSB obesity 3 (mouse)Not determined63644845670448576Mouse
4141094Hrtr1_mheart rate 1 (mouse)Not determined3674146370741463Mouse
14746995Manh60_mmandible shape 60 (mouse)63720266271202662Mouse
1558984Cplaq9_mcircadian period of locomotor activity 9 (mouse)Not determined63864656092584431Mouse
1301326Trbv4c2_mT cell receptor beta variable 4 (mouse)Not determined64086823071356155Mouse
12880424V25Dq4_mvitamin D inactive form serum level QTL 4 (mouse)64157698575576985Mouse
11040600Lmr4c_mleishmaniasis resistance 4c (mouse)64209335876093500Mouse
11040601Lmr4a_mleishmaniasis resistance 4a (mouse)64209335876093500Mouse
11533915Mts4_mmammary tumor susceptibility 4 (mouse)64209335876093500Mouse
1301266Lmr4_mleishmaniasis resistance 4 (mouse)Not determined64209335876093500Mouse
12910785Pwgrq16_mpost-weaning growth rate QTL 16 (mouse)64380374777788506Mouse
12910798Pwgrq5_mpre-weaning growth rate QTL 5 (mouse)64380374777788506Mouse
12910802Pwbwq12_mpost-weaning body weight QTL 12 (mouse)64380374777788506Mouse
12910807Pwbwq11_mpost-weaning body weight QTL 11 (mouse)64380374777788506Mouse
12910809Pwbwq10_mpost-weaning body weight QTL 10 (mouse)64380374777788506Mouse
12910820Ogrq3_moverall growth rate QTL 3 (mouse)64380374777788506Mouse
10043885Cia6c_mcollagen induced arthritis QTL 6c (mouse)Not determined64444280571096451Mouse
1300618Pgia19_mproteoglycan induced arthritis 19 (mouse)Not determined64529099387403016Mouse
10412157Fl1n_mfatty liver 1 in NSY (mouse)Not determined645290993128811995Mouse
4142259Tabw2_mtally ho associated body weight 2 (mouse)Not determined46912919136400690Mouse
25314319Histh6_mhistamine hypersensitivity 6 (mouse)648696934125336963Mouse
25314320Histh5_mhistamine hypersensitivity 5 (mouse)648696934148351498Mouse
4140983Srilp_msleep response to influenza, light phase (mouse)Not determined4870349075424693Mouse
1301962Eila2_methanol induced locomotor activity 2 (mouse)Not determined648703490125333748Mouse
1301254Skts11_mskin tumor susceptibility 11 (mouse)Not determined65115613485156284Mouse
1357683Igf1sl1_mIGF-1 serum levels 1 (mouse)Not determined652138693116132228Mouse
4141028Mclr_mmethylcholanthrene lymphoma resistance (mouse)Not determined5435041188356155Mouse
15039373Adip28_madiposity 28 (mouse)65628519490285194Mouse
15039375Bw41_mbody weight QTL 41 (mouse)65628519490285194Mouse
1558977Skmw10_mskeletal muscle weight 10 (mouse)Not determined65842456692424693Mouse
10043972Obq28_mobesity QTL 28 (mouse)Not determined65851741692517416Mouse
14700792Mencq5_mmeniscus calcification QTL 5 (mouse)65959198563331984Mouse
10412119Stv_mstriatal volumne (mouse)Not determined660026991100026967Mouse
1301740Bwq2_mbody weight QTL 2 (mouse)Not determined66003466394034782Mouse

Markers in Region
D6Mit357  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38660,779,055 - 60,779,153UniSTSGRCm38
MGSCv37660,729,049 - 60,729,147UniSTSGRCm37
Celera662,931,379 - 62,931,477UniSTS
Cytogenetic Map6B3UniSTS
cM Map629.0UniSTS
Whitehead Genetic617.5UniSTS
Whitehead_YAC6 UniSTS
Snca  
Mouse AssemblyChrPosition (strand)SourceJBrowse
MGSCv37660,681,880 - 60,682,145UniSTSGRCm37
MGSCv37660,765,618 - 60,765,747UniSTSGRCm37
Celera662,884,211 - 62,884,476UniSTS
Celera662,967,948 - 62,968,077UniSTS
Cytogenetic Map6B3UniSTS
cM Map629.0UniSTS
PMC153617P1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38660,732,132 - 60,733,131UniSTSGRCm38
MGSCv37660,682,126 - 60,683,125UniSTSGRCm37
Celera662,884,457 - 62,885,456UniSTS
Cytogenetic Map6B3UniSTS
cM Map629.0UniSTS
Snca  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38660,815,624 - 60,815,753UniSTSGRCm38
MGSCv37660,765,618 - 60,765,747UniSTSGRCm37
Celera662,967,948 - 62,968,077UniSTS
Cytogenetic Map6B3UniSTS
cM Map629.0UniSTS
Snca  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38660,731,886 - 60,732,151UniSTSGRCm38
MGSCv37660,681,880 - 60,682,145UniSTSGRCm37
Celera662,884,211 - 62,884,476UniSTS
Cytogenetic Map6B3UniSTS
cM Map629.0UniSTS


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001042451 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_009221 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC154010 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC162311 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF033261 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF044672 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF163865 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF179273 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF277451 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH008229 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK014472 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK156316 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK205246 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC046764 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BY099071 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BY782503 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466523 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000114268   ⟹   ENSMUSP00000109907
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl660,708,563 - 60,805,988 (-)Ensembl
GRCm38.p6 Ensembl660,731,579 - 60,829,004 (-)Ensembl
RefSeq Acc Id: ENSMUST00000163779   ⟹   ENSMUSP00000126067
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl660,708,559 - 60,806,839 (-)Ensembl
GRCm38.p6 Ensembl660,731,575 - 60,829,855 (-)Ensembl
RefSeq Acc Id: ENSMUST00000203177
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl660,791,675 - 60,805,856 (-)Ensembl
GRCm38.p6 Ensembl660,814,691 - 60,828,872 (-)Ensembl
RefSeq Acc Id: ENSMUST00000204586
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl660,785,663 - 60,804,540 (-)Ensembl
GRCm38.p6 Ensembl660,808,679 - 60,827,556 (-)Ensembl
RefSeq Acc Id: NM_001042451   ⟹   NP_001035916
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39660,708,557 - 60,805,988 (-)NCBI
GRCm38660,731,573 - 60,829,004 (-)NCBI
MGSCv37660,681,567 - 60,779,849 (-)RGD
Celera662,883,898 - 62,982,187 (-)RGD
cM Map6 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_009221   ⟹   NP_033247
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39660,708,557 - 60,806,839 (-)NCBI
GRCm38660,731,573 - 60,829,855 (-)ENTREZGENE
MGSCv37660,681,567 - 60,779,849 (-)RGD
Celera662,883,898 - 62,982,187 (-)RGD
cM Map6 ENTREZGENE
Sequence:
Reference Sequences
RefSeq Acc Id: NP_033247   ⟸   NM_009221
- UniProtKB: Q9QUR3 (UniProtKB/Swiss-Prot),   O55042 (UniProtKB/Swiss-Prot),   A0A6P5PVQ9 (UniProtKB/TrEMBL),   A0A8C6HZG6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001035916   ⟸   NM_001042451
- UniProtKB: Q9QUR3 (UniProtKB/Swiss-Prot),   O55042 (UniProtKB/Swiss-Prot),   A0A6P5PVQ9 (UniProtKB/TrEMBL),   A0A8C6HZG6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000126067   ⟸   ENSMUST00000163779
RefSeq Acc Id: ENSMUSP00000109907   ⟸   ENSMUST00000114268

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O55042-F1-model_v2 AlphaFold O55042 1-140 view protein structure

Promoters
RGD ID:6840009
Promoter ID:MM_KWN:46210
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Brain,   MEF_B6
Transcripts:NM_001042451,   UC009CDP.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36660,778,759 - 60,779,259 (-)MPROMDB
RGD ID:6889892
Promoter ID:EPDNEW_M8387
Type:initiation region
Name:Snca_1
Description:Mus musculus synuclein, alpha , transcript variant 1, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M8388  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38660,828,861 - 60,828,921EPDNEW
RGD ID:6889874
Promoter ID:EPDNEW_M8388
Type:initiation region
Name:Snca_2
Description:Mus musculus synuclein, alpha , transcript variant 1, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M8387  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38660,829,794 - 60,829,854EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1277151 AgrOrtholog
Ensembl Genes ENSMUSG00000025889 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSMUSP00000109907 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000126067 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000114268 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000163779 ENTREZGENE, UniProtKB/Swiss-Prot
InterPro Synuclein UniProtKB/Swiss-Prot
  Synuclein_alpha UniProtKB/Swiss-Prot
KEGG Report mmu:20617 UniProtKB/Swiss-Prot
MGD MGI:1277151 ENTREZGENE
NCBI Gene 20617 ENTREZGENE
PANTHER PTHR13820 UniProtKB/Swiss-Prot
  PTHR13820:SF5 UniProtKB/Swiss-Prot
Pfam Synuclein UniProtKB/Swiss-Prot
PhenoGen Snca PhenoGen
PRINTS ASYNUCLEIN UniProtKB/Swiss-Prot
  SYNUCLEIN UniProtKB/Swiss-Prot
UniProt A0A6P5PVQ9 ENTREZGENE
  A0A8C6HZG6 ENTREZGENE
  O55042 ENTREZGENE
  Q9QUR3 ENTREZGENE
  SYUA_MOUSE UniProtKB/Swiss-Prot
UniProt Secondary Q3U130 UniProtKB/Swiss-Prot
  Q9CXF8 UniProtKB/Swiss-Prot
  Q9EQC3 UniProtKB/Swiss-Prot
  Q9QUR3 UniProtKB/Swiss-Prot