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Strain Registration

Strain: Iusm:P

Symbol: Iusm:P
Strain: P
Substrain: Iusm
Full Name: alcohol-preferring
RGD ID: 1641867
Citation ID: RRID:RGD_1641867
Ontology ID: RS:0001377
Alleles: Snca
Also Known As: iP; P/Iusm; iP/Iusm
Type: outbred
Available Source: Not Available
Origination: Indiana Alcohol Research Center at the Indiana University School of Medicine
Description: These were developed at Indiana University for alcohol-preferring behavior through bidirectional selective breeding of Wistar rats from the Walter Reed Army Institute of Research, Washington, DC. A single pair of rats with high preference and another pair with low preference were mated to develop this preference line (P) and non-preference line (Iusm:NP, RGD:1641873).
Last Known Status: Unknown





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Mammalian Phenotype

References

References - curated
# Reference Title Reference Citation
1. Bone mass and strength: phenotypic and genetic relationship to alcohol preference in P/NP and HAD/LAD rats. Alam I, etal., Alcohol Clin Exp Res. 2005 Oct;29(10):1769-76. doi: 10.1097/01.alc.0000183005.28502.4f.
2. Identification of genes influencing skeletal phenotypes in congenic P/NP rats. Alam I, etal., J Bone Miner Res. 2010 Jan 8.
3. Identification of Candidate Genes for Alcohol Preference by Expression Profiling of Congenic Rat Strains. Carr LG, etal., Alcohol Clin Exp Res. 2007 Apr 19;.
4. Development of Congenic Rat Strains for Alcohol Consumption Derived from the Alcohol-Preferring and Nonpreferring Rats. Carr LG, etal., Behav Genet. 2006 Feb 10;:1-6.
5. Alcohol preference and voluntary alcohol intakes of inbred rat strains and the National Institutes of Health heterogeneous stock of rats. Li TK and Lumeng L, Alcohol Clin Exp Res. 1984 Sep-Oct;8(5):485-6. doi: 10.1111/j.1530-0277.1984.tb05708.x.
6. Selective breeding for alcohol preference and associated responses. Li TK, etal., Behav Genet 1993 Mar;23(2):163-70.
7. alpha-Synuclein maps to a quantitative trait locus for alcohol preference and is differentially expressed in alcohol-preferring and -nonpreferring rats. Liang T, etal., Proc Natl Acad Sci U S A 2003 Apr 15;100(8):4690-5.
8. Development of alcohol drinking behavior in rat lines selectively bred for divergent alcohol preference. McKinzie DL, etal., Alcohol Clin Exp Res. 1998 Oct;22(7):1584-90.
9. RGD Strain RSO annotation pipeline RGD Automated Pipelines
10. Quantitative trait locus for body weight identified on rat chromosome 4 in inbred alcohol-preferring and -nonpreferring rats: potential implications for neuropeptide Y and corticotrophin releasing hormone 2. Spence JP, etal., Alcohol. 2013 Feb;47(1):63-7. doi: 10.1016/j.alcohol.2012.10.005.
11. Alcohol-preferring rats show decreased corticotropin-releasing hormone-2 receptor expression and differences in HPA activation compared to alcohol-nonpreferring rats. Yong W, etal., Alcohol Clin Exp Res. 2014 May;38(5):1275-83. doi: 10.1111/acer.12379. Epub 2014 Mar 10.
12. Loss of metabotropic glutamate receptor 2 escalates alcohol consumption. Zhou Z, etal., Proc Natl Acad Sci U S A. 2013 Oct 15;110(42):16963-8. doi: 10.1073/pnas.1309839110. Epub 2013 Sep 30.

Region


Additional Information

RGD Curation Notes
Note Type Note Reference
strain_characteristics These have high voluntary oral consumption of alcohol which leads to high blood alcohol. 631849

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2023-03-08 Iusm:P  alcohol-preferring  P/Iusm  alcohol-preferring  Symbol and/or name change 68913 APPROVED