RGD Reference Report - Alpha- and gamma-synuclein proteins are present in cerebrospinal fluid and are increased in aged subjects with neurodegenerative and vascular changes. - Rat Genome Database
Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   

Alpha- and gamma-synuclein proteins are present in cerebrospinal fluid and are increased in aged subjects with neurodegenerative and vascular changes.

Authors: Mukaetova-Ladinska, EB  Milne, J  Andras, A  Abdel-All, Z  Cerejeira, J  Greally, E  Robson, J  Jaros, E  Perry, R  McKeith, IG  Brayne, C  Xuereb, J  Cleghorn, A  Doherty, J  McIntosh, G  Milton, I 
Citation: Mukaetova-Ladinska EB, etal., Dement Geriatr Cogn Disord. 2008;26(1):32-42. Epub 2008 Jun 25.
RGD ID: 6478792
Pubmed: (View Article at PubMed) PMID:18577885
DOI: Full-text: DOI:10.1159/000141039

BACKGROUND: Disease-specific biomarkers should reflect a fundamental feature of neuropathology and be validated in neuropathologically confirmed cases. Several synaptic proteins have been described in cerebrospinal fluid (CSF) of patients with dementia. In Lewy body disease alpha-synuclein is incorporated within Lewy bodies and alpha-, beta- and gamma-synucleins in dystrophic neuritis. These pathological changes are expected to be seen in CSF. METHODS: A total of 25 CSF post-mortem samples (8 control and 17 subjects with dementia) were used to quantify alpha- and gamma-synucleins and IgG. RESULTS: We describe for the first time the presence of gamma-synuclein in CSF. There is an elevation of both alpha- and gamma-synucleins in CSF from elderly individuals with Alzheimer's disease, Lewy body disease (LBD) and vascular dementia (CVD), compared to normal controls. gamma-Synuclein showed a greater elevation in LBD, IgG in CVD. The elevation of alpha- and gamma-synucleins was seen from Braak stage III onwards and remained stable until Braak stage VI. These results were not influenced by age at death or post-mortem delay. CONCLUSIONS: The reported increases in alpha- and gamma-synucleins and IgG in the ventricular CSF of individuals with dementia are novel findings. They now need to be explored further using a greater number of cases in each subgroup, using lumbar CSF samples to determine their applicability and relevance to a clinical diagnostic setting. It needs to be established whether using these markers may help to discriminate LBD from other types of neurodegenerative and vascular dementias.

Annotation

Disease Annotations    

Objects Annotated

Genes (Rattus norvegicus)
Snca  (synuclein alpha)
Sncg  (synuclein, gamma)

Genes (Mus musculus)
Snca  (synuclein, alpha)
Sncg  (synuclein, gamma)

Genes (Homo sapiens)
SNCA  (synuclein alpha)
SNCG  (synuclein gamma)


Additional Information