RGD Reference Report - Genes associated with Parkinson's disease: regulation of autophagy and beyond. - Rat Genome Database

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Genes associated with Parkinson's disease: regulation of autophagy and beyond.

Authors: Beilina, A  Cookson, MR 
Citation: Beilina A and Cookson MR, J Neurochem. 2015 Jul 30. doi: 10.1111/jnc.13266.
RGD ID: 10450518
Pubmed: PMID:26223426   (View Abstract at PubMed)
PMCID: PMC5834228   (View Article at PubMed Central)
DOI: DOI:10.1111/jnc.13266   (Journal Full-text)

Substantial progress has been made in the genetic basis of Parkinson's disease (PD). In particular, by identifying genes that segregate with inherited PD or show robust association with sporadic disease, and by showing the same genes are found on both lists, we have generated an outline of the cause of this condition. Here, we will discuss what those genes tell us about the underlying biology of PD. We specifically discuss the relationships between protein products of PD genes and show that common links include regulation of the autophagy-lysosome system, an important way by which cells recycle proteins and organelles. We also discuss whether all PD genes should be considered to be in the same pathway and propose that in some cases the relationships are closer, whereas in other cases the interactions are more distant and might be considered separate. Beilina and Cookson review the links between genes for Parkinson's disease (red) and the autophagy-lysosomal system. They propose the hypothesis that many of the known PD genes can be assigned to pathways that affect (I) turnover of mitochondria via mitophagy (II) turnover of several vesicular structures via macroautophagy or chaperone-mediated autophagy or (III) general lysosome function.


Molecular Pathway Annotations    Click to see Annotation Detail View
Objects Annotated

Genes (Rattus norvegicus)
Atp13a2  (ATPase cation transporting 13A2)
Fbxo7  (F-box protein 7)
Gba1  (glucosylceramidase beta 1)
Lrrk2  (leucine-rich repeat kinase 2)
Pink1  (PTEN induced kinase 1)
Prkn  (parkin RBR E3 ubiquitin protein ligase)
Snca  (synuclein alpha)
Vps35  (VPS35 retromer complex component)

Genes (Mus musculus)
Atp13a2  (ATPase type 13A2)
Fbxo7  (F-box protein 7)
Gba1  (glucosylceramidase beta 1)
Lrrk2  (leucine-rich repeat kinase 2)
Pink1  (PTEN induced putative kinase 1)
Prkn  (parkin RBR E3 ubiquitin protein ligase)
Snca  (synuclein, alpha)
Vps35  (VPS35 retromer complex component)

Genes (Homo sapiens)
ATP13A2  (ATPase cation transporting 13A2)
FBXO7  (F-box protein 7)
GBA1  (glucosylceramidase beta 1)
LRRK2  (leucine rich repeat kinase 2)
PINK1  (PTEN induced kinase 1)
PRKN  (parkin RBR E3 ubiquitin protein ligase)
SNCA  (synuclein alpha)
VPS35  (VPS35 retromer complex component)


Additional Information