Gene: PLD1 (phospholipase D1) Homo sapiens
Analyze
Symbol:
PLD1
Name:
phospholipase D1
Description:
Predicted to have N-acylphosphatidylethanolamine-specific phospholipase D activity; phosphatidylinositol binding activity; and phospholipase D activity. Involved in regulation of microvillus assembly and regulation of synaptic vesicle cycle. Localizes to several cellular components, including the apical plasma membrane; cholinergic synapse; and cytoplasmic vesicle. Biomarker of pancreatic ductal adenocarcinoma.
Type:
protein-coding
RefSeq Status:
REVIEWED
Also known as:
choline phosphatase 1; CVDD; hPLD1; phosphatidylcholine-hydrolyzing phospholipase D1; phospholipase D1, phosphatidylcholine-specific; PLD 1
Orthologs:
Species
Gene symbol and name
Data Source
Assertion derived from
less info ...
Orthologs 1
Mus musculus (house mouse):
Pld1 (phospholipase D1) HGNC
EggNOG, Ensembl, HGNC, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, Panther, Treefam
Rattus norvegicus (Norway rat):
Pld1 (phospholipase D1) HGNC
EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Chinchilla lanigera (long-tailed chinchilla):
Pld1 (phospholipase D1) NCBI
Ortholog
Pan paniscus (bonobo/pygmy chimpanzee):
PLD1 (phospholipase D1) NCBI
Ortholog
Canis lupus familiaris (dog):
PLD1 (phospholipase D1) HGNC
Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):
Pld1 (phospholipase D1) NCBI
Ortholog
Sus scrofa (pig):
PLD1 (phospholipase D1) HGNC
Ensembl, Inparanoid, NCBI, OMA, OrthoDB, Panther, Treefam
Chlorocebus sabaeus (African green monkey):
PLD1 (phospholipase D1) NCBI
Ortholog
Heterocephalus glaber (naked mole-rat):
Pld1 (phospholipase D1) NCBI
Ortholog
Other homologs 2
Canis lupus familiaris (dog):
PLD2 (phospholipase D2) HGNC
OrthoMCL
Alliance orthologs 3
Rattus norvegicus (Norway rat):
Pld1 (phospholipase D1)
Alliance
DIOPT (Ensembl Compara, HGNC, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, TreeFam)
Mus musculus (house mouse):
Pld1 (phospholipase D1)
Alliance
DIOPT (Ensembl Compara, HGNC, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, Roundup, TreeFam)
Danio rerio (zebrafish):
si:ch211-168k14.2
Alliance
DIOPT (OrthoFinder, PANTHER, TreeFam)
Danio rerio (zebrafish):
pld1b (phospholipase D1b)
Alliance
DIOPT (Ensembl Compara, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, TreeFam, ZFIN)
Danio rerio (zebrafish):
pld1a (phospholipase D1a)
Alliance
DIOPT (Ensembl Compara, Hieranoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, Roundup, TreeFam, ZFIN)
Caenorhabditis elegans (roundworm):
pld-1
Alliance
DIOPT (Ensembl Compara, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, Roundup, TreeFam)
Drosophila melanogaster (fruit fly):
Pld
Alliance
DIOPT (Ensembl Compara, Hieranoid, InParanoid, OMA, OrthoInspector, PhylomeDB, Roundup, TreeFam)
Saccharomyces cerevisiae (baker's yeast):
SPO14
Alliance
DIOPT (Ensembl Compara, Hieranoid, InParanoid, OrthoInspector, PANTHER, PhylomeDB, Roundup, TreeFam)
Allele / Splice:
See ClinVar data
Latest Assembly:
GRCh38 - Human Genome Assembly GRCh38
Position:
Human Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl GRCh38 Ensembl 3 171,600,404 - 171,810,950 (-) Ensembl GRCh38 3 171,600,404 - 171,810,483 (-) NCBI GRCh38 GRCh38 hg38 GRCh38 GRCh37 3 171,318,195 - 171,528,284 (-) NCBI GRCh37 GRCh37 hg19 GRCh37 Build 36 3 172,801,339 - 172,938,566 (-) NCBI NCBI36 hg18 NCBI36 Build 34 3 172,801,346 - 172,938,574 NCBI Celera 3 169,718,435 - 169,928,143 (-) NCBI Cytogenetic Map 3 q26.31 NCBI HuRef 3 168,688,221 - 168,898,341 (-) NCBI HuRef CHM1_1 3 171,281,084 - 171,491,135 (-) NCBI CHM1_1
JBrowse:
View Region in Genome Browser (JBrowse)
Model
Imported Annotations - ClinVar
Developmental Cardiac Valvular Defect IAGP RGD:12907285 8554872 ClinVar Annotator: match by term: Cardiac valvular defect, developmental ClinVar PMID:27799408 Developmental Cardiac Valvular Defect IAGP RGD:12907287 8554872 ClinVar Annotator: match by term: Cardiac valvular defect, developmental ClinVar PMID:27799408 genetic disease IAGP RGD:10401573 8554872 ClinVar Annotator: match by term: Inborn genetic diseases ClinVar melanoma IAGP RGD:8630690 8554872 ClinVar Annotator: match by term: Malignant melanoma, somatic ClinVar PMID:28492532 Multiple Abnormalities IAGP RGD:10401573 8554872 ClinVar Annotator: match by term: Multiple congenital anomalies ClinVar
Imported Annotations - CTD
Cardiomegaly EXP 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:15988127 middle cerebral artery infarction EXP 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:12374626
(-)-epigallocatechin 3-gallate multiple interactions EXP 6480464 [potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of PLD1 mRNA, PLD1 protein promotes the reaction [epigallocatechin gallate results in increased expression of PTGS2 protein] CTD PMID:15210717 , PMID:22079256 (-)-epigallocatechin 3-gallate increases expression EXP 6480464 epigallocatechin gallate results in increased expression of PLD1 mRNA CTD PMID:22079256 (S)-nicotine decreases expression EXP 6480464 Nicotine results in decreased expression of PLD1 mRNA CTD PMID:18247414 1,1-dichloroethene increases expression ISO RGD:70830 6480464 vinylidene chloride results in increased expression of PLD1 mRNA CTD PMID:26682919 1-octadec-9-enoylglycero-3-phosphate multiple interactions ISO RGD:3349 6480464 1-Butanol inhibits the reaction [PLD1 protein affects the reaction [lysophosphatidic acid results in increased phosphorylation of MAPK1 protein]] more ... CTD PMID:11243883 , PMID:14769825 1-octadec-9-enoylglycero-3-phosphate increases activity ISO RGD:3349 6480464 lysophosphatidic acid results in increased activity of PLD1 protein CTD PMID:11243883 17beta-estradiol increases expression EXP 6480464 Estradiol results in increased expression of PLD1 mRNA CTD PMID:19619570 17beta-estradiol decreases expression ISO RGD:70830 6480464 Estradiol results in decreased expression of PLD1 mRNA CTD PMID:19693291 17beta-estradiol multiple interactions ISO RGD:70830 6480464 [Estradiol co-treated with Progesterone] results in decreased expression of PLD1 mRNA CTD PMID:19693291 17beta-estradiol multiple interactions EXP 6480464 [Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of PLD1 mRNA CTD PMID:19619570 2,2',4,4',5,5'-hexachlorobiphenyl increases activity ISO RGD:3349 6480464 2 more ... CTD PMID:17427178 2,2',4,4'-Tetrabromodiphenyl ether decreases expression ISO RGD:3349 6480464 2 more ... CTD PMID:27291303 2,3,7,8-tetrachlorodibenzodioxine multiple interactions EXP 6480464 [Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of PLD1 mRNA CTD PMID:19619570 2,3,7,8-tetrachlorodibenzodioxine decreases expression EXP 6480464 Tetrachlorodibenzodioxin results in decreased expression of PLD1 mRNA CTD PMID:20106945 , PMID:21632981 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO RGD:70830 6480464 Tetrachlorodibenzodioxin affects the expression of PLD1 mRNA CTD PMID:21570461 2,3,7,8-tetrachlorodibenzodioxine increases expression EXP 6480464 Tetrachlorodibenzodioxin results in increased expression of PLD1 mRNA CTD PMID:19619570 2,3-bisphospho-D-glyceric acid decreases activity EXP 6480464 2, 3-Diphosphoglycerate results in decreased activity of PLD1 protein CTD PMID:16857255 2,3-bisphosphoglyceric acid decreases activity EXP 6480464 2, 3-Diphosphoglycerate results in decreased activity of PLD1 protein CTD PMID:16857255 2,4-dinitrotoluene affects expression ISO RGD:3349 6480464 2, 4-dinitrotoluene affects the expression of PLD1 mRNA CTD PMID:21346803 2,6-dinitrotoluene affects expression ISO RGD:3349 6480464 2, 6-dinitrotoluene affects the expression of PLD1 mRNA CTD PMID:21346803 2-naphthylamine decreases expression EXP 6480464 2-Naphthylamine results in decreased expression of PLD1 mRNA CTD PMID:18247414 3,4-methylenedioxymethamphetamine decreases expression ISO RGD:70830 6480464 N-Methyl-3, 4-methylenedioxyamphetamine results in decreased expression of PLD1 mRNA CTD PMID:26251327 3-\{1-[3-(dimethylamino)propyl]-1H-indol-3-yl\}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione multiple interactions ISO RGD:3349 6480464 bisindolylmaleimide I inhibits the reaction [lysophosphatidic acid results in increased activity of PLD1 protein] CTD PMID:11243883 4,4'-diaminodiphenylmethane increases expression ISO RGD:70830 6480464 4, 4'-diaminodiphenylmethane results in increased expression of PLD1 mRNA CTD PMID:18648102 4,4'-sulfonyldiphenol increases expression ISO RGD:70830 6480464 bis(4-hydroxyphenyl)sulfone results in increased expression of PLD1 mRNA CTD PMID:30951980 5-aza-2'-deoxycytidine affects expression EXP 6480464 Decitabine affects the expression of PLD1 mRNA CTD PMID:17145863 8-Br-cAMP multiple interactions EXP 6480464 8-Bromo Cyclic Adenosine Monophosphate results in increased expression of and results in increased activity of PLD1 protein more ... CTD PMID:17065600 actinomycin D multiple interactions EXP 6480464 PLD1 protein inhibits the reaction [Dactinomycin results in increased cleavage of PARP1 protein] more ... CTD PMID:14640974 aflatoxin B1 increases expression EXP 6480464 Aflatoxin B1 results in increased expression of PLD1 mRNA CTD PMID:21641981 all-trans-retinoic acid increases expression EXP 6480464 Tretinoin results in increased expression of PLD1 mRNA CTD PMID:16249480 , PMID:21934132 ammonium chloride affects expression ISO RGD:3349 6480464 Ammonium Chloride affects the expression of PLD1 mRNA CTD PMID:16483693 amphetamine increases expression ISO RGD:3349 6480464 Amphetamine results in increased expression of PLD1 mRNA CTD PMID:30779732 arsane affects methylation EXP 6480464 Arsenic affects the methylation of PLD1 gene CTD PMID:25304211 arsenic atom affects methylation EXP 6480464 Arsenic affects the methylation of PLD1 gene CTD PMID:25304211 benzene multiple interactions ISO RGD:3349 6480464 [Benzene co-treated with methylmercury II co-treated with Trichloroethylene] results in increased expression of PLD1 mRNA CTD PMID:17905399 benzo[a]pyrene decreases expression EXP 6480464 Benzo(a)pyrene results in decreased expression of PLD1 mRNA CTD PMID:18247414 benzo[a]pyrene increases expression EXP 6480464 Benzo(a)pyrene results in increased expression of PLD1 mRNA CTD PMID:17879257 , PMID:26238291 benzo[a]pyrene increases expression ISO RGD:70830 6480464 Benzo(a)pyrene results in increased expression of PLD1 mRNA CTD PMID:23735875 benzo[a]pyrene diol epoxide I increases expression EXP 6480464 7 more ... CTD PMID:26238291 bis(2-ethylhexyl) phthalate increases expression ISO RGD:3349 6480464 Diethylhexyl Phthalate results in increased expression of PLD1 protein CTD PMID:21079920 bis(2-ethylhexyl) phthalate decreases expression EXP 6480464 Diethylhexyl Phthalate results in decreased expression of PLD1 protein CTD PMID:31163220 bisphenol A decreases expression EXP 6480464 bisphenol A results in decreased expression of PLD1 mRNA CTD PMID:20678512 bisphenol A increases expression EXP 6480464 bisphenol A results in increased expression of PLD1 mRNA CTD PMID:29275510 bisphenol A increases expression ISO RGD:70830 6480464 bisphenol A results in increased expression of PLD1 mRNA CTD PMID:30951980 bisphenol A increases methylation ISO RGD:3349 6480464 bisphenol A results in increased methylation of PLD1 gene CTD PMID:28505145 bisphenol A decreases expression ISO RGD:3349 6480464 bisphenol A results in decreased expression of PLD1 mRNA CTD PMID:25181051 , PMID:30816183 bisphenol F increases expression ISO RGD:70830 6480464 bisphenol F results in increased expression of PLD1 mRNA CTD PMID:30951980 butan-1-ol multiple interactions ISO RGD:3349 6480464 1-Butanol inhibits the reaction [PLD1 protein affects the reaction [lysophosphatidic acid results in increased phosphorylation of MAPK1 protein]] more ... CTD PMID:11243883 , PMID:15652502 butan-1-ol decreases activity ISO RGD:70830 6480464 1-Butanol results in decreased activity of PLD1 protein CTD PMID:19284563 butan-1-ol decreases activity ISO RGD:3349 6480464 1-Butanol results in decreased activity of PLD1 protein CTD PMID:15652502 , PMID:18344600 carbon nanotube increases expression ISO RGD:70830 6480464 Nanotubes, Carbon results in increased expression of PLD1 mRNA CTD PMID:25620056 ciguatoxin CTX1B affects expression ISO RGD:70830 6480464 Ciguatoxins affects the expression of PLD1 mRNA CTD PMID:18353800 cisplatin increases expression ISO RGD:70830 6480464 Cisplatin results in increased expression of PLD1 mRNA CTD PMID:21151649 clofibrate decreases expression ISO RGD:70830 6480464 Clofibrate results in decreased expression of PLD1 mRNA CTD PMID:17585979 cobalt dichloride increases activity EXP 6480464 cobaltous chloride results in increased activity of PLD1 protein CTD PMID:17640750 cobalt dichloride decreases expression ISO RGD:3349 6480464 cobaltous chloride results in decreased expression of PLD1 mRNA CTD PMID:24386269 cobalt dichloride multiple interactions EXP 6480464 2-(4-nitrophenyl)-4-(4-fluorophenyl)-5-(4-pyridinyl)-1H-imidazole inhibits the reaction [PLD1 protein promotes the reaction [cobaltous chloride results in increased expression of PTGS2 protein]] more ... CTD PMID:17640750 copper(II) sulfate decreases expression EXP 6480464 Copper Sulfate results in decreased expression of PLD1 mRNA CTD PMID:19549813 crocidolite asbestos affects expression EXP 6480464 Asbestos, Crocidolite affects the expression of PLD1 mRNA CTD PMID:17331233 cyclosporin A decreases expression EXP 6480464 Cyclosporine results in decreased expression of PLD1 mRNA CTD PMID:20106945 , PMID:25562108 decabromodiphenyl ether decreases expression ISO RGD:3349 6480464 decabromobiphenyl ether results in decreased expression of PLD1 mRNA CTD PMID:23640034 dexamethasone increases expression ISO RGD:70830 6480464 Dexamethasone results in increased expression of PLD1 mRNA CTD PMID:22733784 dibutyl phthalate increases expression ISO RGD:70830 6480464 Dibutyl Phthalate results in increased expression of PLD1 mRNA CTD PMID:21266533 diclofenac increases expression ISO RGD:70830 6480464 Diclofenac results in increased expression of PLD1 mRNA CTD PMID:26934552 diuron increases expression ISO RGD:3349 6480464 Diuron results in increased expression of PLD1 mRNA CTD PMID:21551480 dorsomorphin multiple interactions EXP 6480464 [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... CTD PMID:27188386 doxorubicin decreases expression EXP 6480464 Doxorubicin results in decreased expression of PLD1 mRNA CTD PMID:29803840 endosulfan decreases expression ISO RGD:3349 6480464 Endosulfan results in decreased expression of PLD1 mRNA CTD PMID:29391264 entinostat increases expression EXP 6480464 entinostat results in increased expression of PLD1 mRNA CTD PMID:27188386 ethanol affects expression ISO RGD:70830 6480464 Ethanol affects the expression of PLD1 mRNA CTD PMID:30319688 ethanol increases expression ISO RGD:70830 6480464 Ethanol results in increased expression of PLD1 mRNA CTD PMID:30319688 formaldehyde increases expression EXP 6480464 Formaldehyde results in increased expression of PLD1 mRNA CTD PMID:23649840 furan increases expression ISO RGD:3349 6480464 furan results in increased expression of PLD1 mRNA CTD PMID:27387713 ganglioside GM1 multiple interactions ISO RGD:3349 6480464 PLD1 protein affects the reaction [dinitrophenyl-bovine serum albumin affects the localization of G(M1) Ganglioside] CTD PMID:19794068 genistein multiple interactions ISO RGD:3349 6480464 Genistein inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of and results in increased activity of PLD1 protein] CTD PMID:15150437 Goe 6976 multiple interactions ISO RGD:3349 6480464 Go 6976 inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of and results in increased activity of PLD1 protein] CTD PMID:15150437 Goe 6976 multiple interactions EXP 6480464 Go 6976 inhibits the reaction [Tobacco Smoke Pollution analog results in increased expression of PLD1 mRNA], Go 6976 inhibits the reaction [Tobacco Smoke Pollution analog results in increased phosphorylation of PLD1 protein] CTD PMID:26763395 hexadecanoic acid multiple interactions EXP 6480464 [Palmitic Acid co-treated with Oleic Acid co-treated with TNF protein] affects the expression of PLD1 mRNA CTD PMID:30547786 hydrogen peroxide affects expression EXP 6480464 Hydrogen Peroxide affects the expression of PLD1 mRNA CTD PMID:20044591 hydrogen peroxide multiple interactions ISO RGD:3349 6480464 [Hydrogen Peroxide co-treated with Vanadates] results in increased phosphorylation of [PLD1 protein binds to PRKCA protein] more ... CTD PMID:15150437 hydroquinone decreases expression EXP 6480464 hydroquinone results in decreased expression of PLD1 mRNA CTD PMID:31256213 indometacin decreases expression ISO RGD:3349 6480464 Indomethacin results in decreased expression of PLD1 mRNA CTD PMID:25972201 irinotecan affects expression ISO RGD:3349 6480464 Irinotecan affects the expression of PLD1 mRNA CTD PMID:20097248 isoprenaline increases expression ISO RGD:70830 6480464 Isoproterenol results in increased expression of PLD1 mRNA CTD PMID:20003209 lithium chloride increases expression EXP 6480464 Lithium Chloride results in increased expression of PLD1 mRNA CTD PMID:23527032 lithocholic acid increases expression ISO RGD:70830 6480464 Lithocholic Acid results in increased expression of PLD1 mRNA CTD PMID:21480330 , PMID:23034213 lithocholic acid multiple interactions ISO RGD:70830 6480464 SMAD3 protein promotes the reaction [Lithocholic Acid results in increased expression of PLD1 mRNA] CTD PMID:23034213 melanins multiple interactions EXP 6480464 [TYR protein results in decreased expression of and results in decreased activity of PLD1 protein] which results in decreased abundance of Melanins CTD PMID:14615486 mercury atom increases phosphorylation ISO RGD:70830 6480464 Mercury results in increased phosphorylation of PLD1 protein CTD PMID:21994240 mercury(0) increases phosphorylation ISO RGD:70830 6480464 Mercury results in increased phosphorylation of PLD1 protein CTD PMID:21994240 methyl methanesulfonate decreases expression EXP 6480464 Methyl Methanesulfonate results in decreased expression of PLD1 mRNA CTD PMID:23649840 methylmercury(1+) multiple interactions ISO RGD:3349 6480464 [Benzene co-treated with methylmercury II co-treated with Trichloroethylene] results in increased expression of PLD1 mRNA CTD PMID:17905399 mifepristone increases expression EXP 6480464 Mifepristone results in increased expression of PLD1 mRNA CTD PMID:17584828 mono(2-ethylhexyl) phthalate increases expression ISO RGD:3349 6480464 mono-(2-ethylhexyl)phthalate results in increased expression of PLD1 mRNA CTD PMID:16809437 N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide multiple interactions EXP 6480464 N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [PLD1 protein promotes the reaction [cobaltous chloride results in increased expression of PTGS2 protein]] CTD PMID:17640750 N-acetyl-L-cysteine multiple interactions EXP 6480464 Acetylcysteine inhibits the reaction [PLD1 protein promotes the reaction [cobaltous chloride results in increased expression of PTGS2 protein]] CTD PMID:17640750 N-formyl-L-methionyl-L-leucyl-L-phenylalanine multiple interactions EXP 6480464 PLD1 protein affects the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased phosphorylation of and results in increased activity of MAPK1 protein], PLD1 protein affects the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased phosphorylation of and results in increased activity of MAPK3 protein] CTD PMID:11427526 N-formyl-L-methionyl-L-leucyl-L-phenylalanine multiple interactions ISO RGD:3349 6480464 PLD1 protein affects the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased abundance of Reactive Oxygen Species] CTD PMID:17560994 N-methyl-4-phenylpyridinium increases expression ISO RGD:3349 6480464 1-Methyl-4-phenylpyridinium results in increased expression of PLD1 mRNA CTD PMID:28801915 N-nitrosodiethylamine increases expression ISO RGD:70830 6480464 Diethylnitrosamine results in increased expression of PLD1 mRNA CTD PMID:24535843 nicotine decreases expression EXP 6480464 Nicotine results in decreased expression of PLD1 mRNA CTD PMID:18247414 oleic acid multiple interactions EXP 6480464 [Palmitic Acid co-treated with Oleic Acid co-treated with TNF protein] affects the expression of PLD1 mRNA CTD PMID:30547786 oxaliplatin multiple interactions ISO RGD:3349 6480464 [oxaliplatin co-treated with Topotecan] results in decreased expression of PLD1 mRNA CTD PMID:25729387 oxycodone decreases expression ISO RGD:3349 6480464 Oxycodone results in decreased expression of PLD1 mRNA CTD PMID:23439660 paracetamol decreases expression EXP 6480464 Acetaminophen results in decreased expression of PLD1 mRNA CTD PMID:21420995 perfluorooctane-1-sulfonic acid decreases expression ISO RGD:3349 6480464 perfluorooctane sulfonic acid results in decreased expression of PLD1 mRNA CTD PMID:19162173 perfluorooctanoic acid decreases expression ISO RGD:3349 6480464 perfluorooctanoic acid results in decreased expression of PLD1 mRNA CTD PMID:19162173 phenobarbital affects expression ISO RGD:70830 6480464 Phenobarbital affects the expression of PLD1 mRNA CTD PMID:23091169 phenylarsine oxide multiple interactions EXP 6480464 oxophenylarsine inhibits the reaction [Tobacco Smoke Pollution analog results in increased expression of PLD1 mRNA], oxophenylarsine inhibits the reaction [Tobacco Smoke Pollution analog results in increased phosphorylation of PLD1 protein] CTD PMID:26763395 phenylmercury acetate increases expression EXP 6480464 Phenylmercuric Acetate results in increased expression of PLD1 mRNA CTD PMID:26272509 phenylmercury acetate multiple interactions EXP 6480464 [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PLD1 mRNA CTD PMID:27188386 phorbol 13-acetate 12-myristate increases activity ISO RGD:3349 6480464 Tetradecanoylphorbol Acetate results in increased activity of PLD1 protein CTD PMID:15067002 phorbol 13-acetate 12-myristate multiple interactions ISO RGD:3349 6480464 toxB protein, Clostridium difficile inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of PLD1 protein] CTD PMID:14769825 phosphatidic acid increases activity EXP 6480464 Phosphatidic Acids results in increased activity of PLD1 protein CTD PMID:16857255 pirinixic acid multiple interactions ISO RGD:70830 6480464 [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of PLD1 mRNA CTD PMID:19710929 potassium chromate decreases expression EXP 6480464 potassium chromate(VI) results in decreased expression of PLD1 mRNA CTD PMID:22079256 potassium chromate multiple interactions EXP 6480464 [potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of PLD1 mRNA CTD PMID:22079256 progesterone multiple interactions ISO RGD:70830 6480464 [Estradiol co-treated with Progesterone] results in decreased expression of PLD1 mRNA CTD PMID:19693291 progesterone decreases expression ISO RGD:70830 6480464 Progesterone results in decreased expression of PLD1 mRNA CTD PMID:19693291 propiconazole increases expression ISO RGD:70830 6480464 propiconazole results in increased expression of PLD1 mRNA CTD PMID:21278054 prostaglandin E2 multiple interactions EXP 6480464 PLD1 protein promotes the reaction [cobaltous chloride results in increased abundance of Dinoprostone] CTD PMID:17640750 quercetin decreases expression EXP 6480464 Quercetin results in decreased expression of PLD1 mRNA, Quercetin results in decreased expression of PLD1 protein CTD PMID:21632981 , PMID:21867678 reactive oxygen species multiple interactions ISO RGD:3349 6480464 PLD1 protein affects the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased abundance of Reactive Oxygen Species] CTD PMID:17560994 reactive oxygen species multiple interactions EXP 6480464 Reactive Oxygen Species affects the reaction [PLD1 protein promotes the reaction [cobaltous chloride results in increased expression of PTGS2 protein]] CTD PMID:17640750 resveratrol multiple interactions EXP 6480464 resveratrol results in decreased activity of [C5 protein results in increased localization of and results in increased activity of PLD1 protein] CTD PMID:19284563 rotenone decreases expression ISO RGD:3349 6480464 Rotenone results in decreased expression of PLD1 mRNA CTD PMID:28374803 rottlerin multiple interactions EXP 6480464 rottlerin inhibits the reaction [PLD1 protein promotes the reaction [cobaltous chloride results in increased expression of PTGS2 protein]] CTD PMID:17640750 SB 203580 multiple interactions EXP 6480464 SB 203580 inhibits the reaction [Tobacco Smoke Pollution analog results in increased expression of PLD1 mRNA], SB 203580 inhibits the reaction [Tobacco Smoke Pollution analog results in increased phosphorylation of PLD1 protein] CTD PMID:26763395 SB 431542 multiple interactions EXP 6480464 [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... CTD PMID:27188386 sodium arsenite decreases expression EXP 6480464 sodium arsenite results in decreased expression of PLD1 mRNA CTD PMID:20371982 , PMID:28595984 Soman increases expression ISO RGD:3349 6480464 Soman results in increased expression of PLD1 mRNA CTD PMID:19281266 testosterone decreases expression ISO RGD:70830 6480464 Testosterone results in decreased expression of PLD1 mRNA CTD PMID:19693291 tetracycline increases expression ISO RGD:70830 6480464 Tetracycline results in increased expression of PLD1 mRNA CTD PMID:16917069 titanium dioxide increases expression ISO RGD:70830 6480464 titanium dioxide results in increased expression of PLD1 mRNA CTD PMID:23557971 topiramate increases expression ISO RGD:3349 6480464 topiramate results in increased expression of PLD1 mRNA CTD PMID:16979414 topotecan decreases expression ISO RGD:3349 6480464 Topotecan results in decreased expression of PLD1 mRNA CTD PMID:25729387 topotecan multiple interactions ISO RGD:3349 6480464 [oxaliplatin co-treated with Topotecan] results in decreased expression of PLD1 mRNA CTD PMID:25729387 trichloroethene multiple interactions ISO RGD:3349 6480464 [Benzene co-treated with methylmercury II co-treated with Trichloroethylene] results in increased expression of PLD1 mRNA CTD PMID:17905399 trichostatin A increases expression EXP 6480464 trichostatin A results in increased expression of PLD1 mRNA CTD PMID:24935251 , PMID:26238599 troglitazone decreases expression ISO RGD:70830 6480464 troglitazone results in decreased expression of PLD1 mRNA CTD PMID:28973697 troglitazone increases expression EXP 6480464 troglitazone results in increased expression of PLD1 mRNA CTD PMID:19140230 valdecoxib decreases expression ISO RGD:3349 6480464 valdecoxib results in decreased expression of PLD1 mRNA CTD PMID:24136188 valproic acid affects expression ISO RGD:70830 6480464 Valproic Acid affects the expression of PLD1 mRNA CTD PMID:17963808 valproic acid multiple interactions EXP 6480464 [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PLD1 mRNA CTD PMID:27188386 valproic acid increases expression EXP 6480464 Valproic Acid results in increased expression of PLD1 mRNA CTD PMID:23179753 more ... valproic acid affects expression EXP 6480464 Valproic Acid affects the expression of PLD1 mRNA CTD PMID:25979313 vorinostat increases expression EXP 6480464 vorinostat results in increased expression of PLD1 mRNA CTD PMID:26238599
Gene-Chemical Interaction Annotations
