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Strain Registration

Strain: NP.P-(D4Rat119-D4Rat55)/Iusm

Symbol: NP.P-(D4Rat119-D4Rat55)/Iusm
Strain: NP.P-(D4Rat119-D4Rat55)
Substrain: Iusm
RGD ID: 1641877
Citation ID: RRID:RGD_1641877
Ontology ID: RS:0001376
Alleles: Akr1b1;   Npy;   Snca;   Grid2;   Baiap1;   Zfp212;   Ppm1k;   Sos1;   Dgki
Also Known As: C2; NP.P-(D4Rat119-D4Rat55); NP.P-(D4Rat119-D4Rat55)/Iusm; NP.P-(D4Mgh16-D4Rat55); iNP.iP; NP.P
Type: congenic
Available Source: Not Available
Origination: Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana
Description: Male iP and female iNP rats were crossed to get F1 animals which were further backcrossed to iNP rats for 10 generations, this was followed by intercross to generate the congenic strains, these animals were selected by marker-assisted selection
Last Known Status: Unknown
Position
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8465,060,960 - 127,749,483RGD_MAPPER_PIPELINE
mRatBN7.24126,192,368 - 126,192,555RGD_MAPPER_PIPELINEmRatBN7.2
Rnor_6.0462,947,687 - 125,671,711RGD_MAPPER_PIPELINERnor6.0
Rnor_5.04190,188,458 - 190,188,644RGD_MAPPER_PIPELINERnor5.0
RGSC_v3.4462,832,008 - 127,941,994RGD_MAPPER_PIPELINERGSC3.4






  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
NP.P-(D4Rat119-D4Rat55)/IusmRatWeight Loss  IAGP 2317896as compared to NP/IusmRGD 

Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
NP.P-(D4Rat119-D4Rat55)/IusmRatdecreased body weight  IAGP 2317896as compared to NP/IusmRGD 
NP.P-(D4Rat119-D4Rat55)/IusmRathyperactivity  IAGP 2317896as compared to NP/IusmRGD 
NP.P-(D4Rat119-D4Rat55)/IusmRatincreased alcohol consumption  IAGP 1578304 RGD 
NP.P-(D4Rat119-D4Rat55)/IusmRatincreased bone mineral density  IAGP 2317896as compared to P/IusmRGD 

Rat Strain
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
NP.P-(D4Rat119-D4Rat55)/IusmRatNP.P-(D4Rat119-D4Rat55)/Iusm  IEA 7241799 RGD 

Vertebrate Trait
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
NP.P-(D4Rat119-D4Rat55)/IusmRatdrinking behavior trait  EXP 1578304 RGD 


#
Reference Title
Reference Citation
1. Identification of genes influencing skeletal phenotypes in congenic P/NP rats. Alam I, etal., J Bone Miner Res. 2010 Jan 8.
2. Identification of Candidate Genes for Alcohol Preference by Expression Profiling of Congenic Rat Strains. Carr LG, etal., Alcohol Clin Exp Res. 2007 Apr 19;.
3. Development of Congenic Rat Strains for Alcohol Consumption Derived from the Alcohol-Preferring and Nonpreferring Rats. Carr LG, etal., Behav Genet. 2006 Feb 10;:1-6.
4. RGD Strain RSO annotation pipeline RGD Automated Pipelines



Flank 1 / 1 (D4Rat119)
Rat AssemblyChrPosition (strand)Source
GRCr8465,060,960 - 65,061,193 (+)Marker Load Pipeline
Rnor_6.0462,947,687 - 62,947,927NCBI
RGSC_v3.4462,832,009 - 62,832,241UniSTS
RGSC_v3.4462,832,008 - 62,832,241RGD
RGSC_v3.1463,108,139 - 63,108,371RGD
Celera459,141,073 - 59,141,305UniSTS
RH 3.4 Map4371.7RGD
RH 3.4 Map4371.7UniSTS
SHRSP x BN Map432.92RGD
SHRSP x BN Map432.92UniSTS

Flank 2 / 1 (D4Rat55)
Rat AssemblyChrPosition (strand)Source
GRCr84127,749,296 - 127,749,483 (+)Marker Load Pipeline
mRatBN7.24126,192,368 - 126,192,555 (+)MAPPER
Rnor_6.04125,671,525 - 125,671,711NCBI
Rnor_5.04190,188,458 - 190,188,644UniSTS
RGSC_v3.44127,941,808 - 127,941,994UniSTS
RGSC_v3.44127,941,807 - 127,941,994RGD
RGSC_v3.14128,186,649 - 128,186,835RGD
Celera4115,103,999 - 115,104,185UniSTS
RH 3.4 Map4744.2RGD
RH 3.4 Map4744.2UniSTS
RH 2.0 Map4840.3RGD
SHRSP x BN Map455.5RGD
Cytogenetic Map4q34UniSTS
1 to 1 of 1 rows
Symbol
Name
Trait
Alc22 Alcohol consumption QTL 22 drinking behavior trait   (VT:0001422)    
1 to 1 of 1 rows


Note Type Note Reference
strain_characteristics These are homozygous for the P allele which is responsible for increased alcohol consumption 1578304
strain_other Microarray profiling of gene expression of 5 brain regions confirmed 19 genes and detected an additional 15 genes in this region 1624272