Dgki (diacylglycerol kinase, iota) - Rat Genome Database

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Gene: Dgki (diacylglycerol kinase, iota) Rattus norvegicus
Analyze
Symbol: Dgki
Name: diacylglycerol kinase, iota
RGD ID: 735049
Description: Enables diacylglycerol kinase activity. Involved in diacylglycerol metabolic process; lipid phosphorylation; and phosphatidic acid biosynthetic process. Located in several cellular components, including postsynaptic density; presynaptic active zone; and synaptic membrane. Is active in glutamatergic synapse and synaptic vesicle. Is extrinsic component of postsynaptic density membrane and extrinsic component of presynaptic active zone membrane. Orthologous to human DGKI (diacylglycerol kinase iota); PARTICIPATES IN glycerolipid metabolic pathway; glycerophospholipid metabolic pathway; phosphatidylinositol 3-kinase signaling pathway; INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: DAG kinase iota; DGK-iota; diacylglycerol kinase iota; diacylglycerol kinase iota-3; diglyceride kinase iota; LOC688705; rDGKi-3
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Is Marker For: Strains:   NP.P-(D4Rat119-D4Rat55)/Iusm  
Candidate Gene For: Alc22
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2465,410,878 - 65,872,733 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl465,420,108 - 65,872,733 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx470,368,009 - 70,814,746 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0466,289,073 - 66,735,818 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0464,686,142 - 65,132,286 (-)NCBIRnor_WKY
Rnor_6.0464,365,115 - 64,831,473 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl464,374,342 - 64,831,473 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0464,193,188 - 64,653,936 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4464,207,192 - 64,663,627 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1464,483,440 - 64,939,757 (-)NCBI
Celera460,450,503 - 60,895,770 (-)NCBICelera
Cytogenetic Map4q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Cloning and characterization of diacylglycerol kinase iota splice variants in rat brain. Ito T, etal., J Biol Chem 2004 May 28;279(22):23317-26. Epub 2004 Mar 15.
3. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
4. GOA pipeline RGD automated data pipeline
5. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
7. Comprehensive gene review and curation RGD comprehensive gene curation
8. DGKiota regulates presynaptic release during mGluR-dependent LTD. Yang J, etal., EMBO J. 2011 Jan 5;30(1):165-80. doi: 10.1038/emboj.2010.286. Epub 2010 Nov 30.
Additional References at PubMed
PMID:8889548   PMID:9830018   PMID:11244494   PMID:15894621  


Genomics

Comparative Map Data
Dgki
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2465,410,878 - 65,872,733 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl465,420,108 - 65,872,733 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx470,368,009 - 70,814,746 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0466,289,073 - 66,735,818 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0464,686,142 - 65,132,286 (-)NCBIRnor_WKY
Rnor_6.0464,365,115 - 64,831,473 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl464,374,342 - 64,831,473 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0464,193,188 - 64,653,936 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4464,207,192 - 64,663,627 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1464,483,440 - 64,939,757 (-)NCBI
Celera460,450,503 - 60,895,770 (-)NCBICelera
Cytogenetic Map4q22NCBI
DGKI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh387137,381,037 - 137,846,974 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl7137,381,037 - 137,847,092 (-)EnsemblGRCh38hg38GRCh38
GRCh377137,065,783 - 137,531,720 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 367136,724,925 - 137,182,149 (-)NCBINCBI36Build 36hg18NCBI36
Build 347136,531,639 - 136,988,864NCBI
Celera7131,813,301 - 132,270,574 (-)NCBICelera
Cytogenetic Map7q33NCBI
HuRef7131,379,554 - 131,839,437 (-)NCBIHuRef
CHM1_17137,007,692 - 137,465,171 (-)NCBICHM1_1
T2T-CHM13v2.07138,690,170 - 139,156,064 (-)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v27136,418,404 - 136,876,991 (-)NCBI
Dgki
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39636,814,316 - 37,281,034 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl636,822,957 - 37,277,119 (-)EnsemblGRCm39 Ensembl
GRCm38636,837,381 - 37,300,955 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl636,846,022 - 37,300,184 (-)EnsemblGRCm38mm10GRCm38
MGSCv37636,796,022 - 37,249,976 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36636,776,174 - 37,229,582 (-)NCBIMGSCv36mm8
Celera636,822,759 - 37,278,859 (-)NCBICelera
Cytogenetic Map6B1NCBI
Dgki
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554945,264,414 - 5,539,540 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554945,119,419 - 5,541,058 (+)NCBIChiLan1.0ChiLan1.0
DGKI
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.17141,833,815 - 142,142,262 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl7141,841,852 - 142,142,310 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v07129,339,330 - 129,812,443 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
DGKI
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11610,975,394 - 11,250,430 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1610,682,935 - 11,248,029 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1611,843,635 - 12,272,254 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01610,791,210 - 11,215,338 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1610,790,994 - 11,235,389 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11611,253,927 - 11,684,568 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01610,355,968 - 10,784,441 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01610,498,287 - 10,926,978 (+)NCBIUU_Cfam_GSD_1.0
Dgki
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440511817,082,903 - 17,377,888 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365921,844,315 - 2,270,814 (-)EnsemblSpeTri2.0
SpeTri2.0NW_0049365921,843,438 - 2,136,905 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DGKI
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1811,705,093 - 12,177,267 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11811,705,055 - 12,187,098 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21812,574,313 - 12,854,605 (+)NCBISscrofa10.2Sscrofa10.2susScr3
DGKI
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.121106,074,522 - 106,544,009 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl21106,076,928 - 106,317,825 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660722,926,590 - 3,409,867 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Dgki
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476517,669,645 - 18,124,967 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476517,663,347 - 18,128,007 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Dgki
3339 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:246
Count of miRNA genes:152
Interacting mature miRNAs:175
Transcripts:ENSRNOT00000033268
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
619616Bp79Blood pressure QTL 790.0292arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)4521460278882945Rat
2303168Bp330Blood pressure QTL 3304.250.017arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)45214602146446691Rat
1358203Stl19Serum triglyceride level QTL 192.80.002blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)4521829465958103Rat
631261Tcas3Tongue tumor susceptibility QTL 36.88tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)41081417091360527Rat
2316958Gluco58Glucose level QTL 5810blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)411320076180699135Rat
6909122Insul22Insulin level QTL 224.63blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)42690728575585128Rat
6909128Pancm4Pancreatic morphology QTL 411.35pancreas mass (VT:0010144)pancreas wet weight (CMO:0000626)42690728575585128Rat
8655906Rf60Renal function QTL 603.8blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)42949419581006281Rat
12798520Anxrr55Anxiety related response QTL 554.450.01locomotor behavior trait (VT:0001392)number of rearing movements with lid-pushing in an experimental apparatus (CMO:0002715)432583980114627242Rat
8552782Vie1Viral induced encephalitis QTL 126.4brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)43443048482490359Rat
8552801Bw143Body weight QTL 1437.3body mass (VT:0001259)change in body weight to body weight ratio (CMO:0002216)43443048482490359Rat
8552809Vie5Viral induced encephalitis QTL 525.3brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)43443048482490359Rat
8655961Kidm43Kidney mass QTL 4318kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)436303261103194984Rat
1358352Srcrt3Stress Responsive Cort QTL 32.29blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)438465774146803430Rat
61475Aia2Adjuvant induced arthritis QTL 25.8joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)43950527573892441Rat
1331807Rf31Renal function QTL 312.988urine potassium amount (VT:0010539)urine potassium level (CMO:0000128)43952426474726312Rat
1300139Hrtrt6Heart rate QTL 62.85heart pumping trait (VT:2000009)heart rate (CMO:0000002)439524264116179656Rat
61445Strs3Sensitivity to stroke QTL 33cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)44043338885433388Rat
8694439Bw168Body weight QTL 1689.570.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)44043341485433414Rat
6893678Bw108Body weight QTL 1082.60.006body mass (VT:0001259)body weight (CMO:0000012)44345797688457976Rat
1576305Emca6Estrogen-induced mammary cancer QTL 65.8mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)444463720155883716Rat
1354612Foco1Food consumption QTL 18.87eating behavior trait (VT:0001431)food intake rate (CMO:0000427)444463908148090542Rat
1354660Salc1Saline consumption QTL 111.26drinking behavior trait (VT:0001422)saline drink intake rate (CMO:0001627)444463908148090542Rat
2312567Glom19Glomerulus QTL 191.90.006kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)445456990146803430Rat
1298082Stresp4Stress response QTL 4blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)450119848146803430Rat
4889969Bss96Bone structure and strength QTL 964.9tibia size trait (VT:0100001)tibia cortical bone volume (CMO:0001725)45664777678882945Rat
4889972Bss97Bone structure and strength QTL 975.6tibia size trait (VT:0100001)tibia total bone volume (CMO:0001724)45664777678882945Rat
5685009Bmd86Bone mineral density QTL 863.7tibia mineral mass (VT:1000283)bone mineral density (CMO:0001226)45664777678882945Rat
5685012Bmd87Bone mineral density QTL 875.1tibia mineral mass (VT:1000283)bone mineral content (CMO:0001554)45664777678882945Rat
70200Alc18Alcohol consumption QTL 189.2drinking behavior trait (VT:0001422)ethanol intake volume to total fluid intake volume ratio (CMO:0001591)456647873149491524Rat
1641833Alc21Alcohol consumption QTL 218.60.0001drinking behavior trait (VT:0001422)ethanol drink intake rate (CMO:0001407)456698790126192555Rat
631546Bp86Blood pressure QTL 863.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)45711443291360801Rat
634311Sach7Saccharin preference QTL 7taste sensitivity trait (VT:0001986)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)457114432102114432Rat
61336Bp21Blood pressure QTL 214.6arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)45711470578881294Rat
1358363Sradr3Stress Responsive Adrenal Weight QTL 36.19adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)457486946102486946Rat
1558651Swd3Spike wave discharge measurement QTL 34.620.000024brain electrophysiology trait (VT:0010557)brain spike-and-wave discharge frequency (CMO:0001742)45843213392991462Rat
631671Iddm11Insulin dependent diabetes mellitus QTL 113.60.0012blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)45863587778886137Rat
738009Sach4Saccharine consumption QTL 44.90.000016consumption behavior trait (VT:0002069)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)459948935154902892Rat
738016Alc16Alcohol consumption QTL 163.60.00015consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)459948935154902892Rat
738031Alc14Alcohol consumption QTL 147.60.00003consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)459948935154902892Rat
1578657Bss12Bone structure and strength QTL 128.9femur morphology trait (VT:0000559)femoral neck cross-sectional area (CMO:0001697)460220938105220938Rat
1578658Bss13Bone structure and strength QTL 138femur strength trait (VT:0010010)femoral neck polar moment of inertia (CMO:0001670)460220938105220938Rat
2300179Bmd50Bone mineral density QTL 505.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)460928534105928534Rat
1549843Bw53Body weight QTL 530.0001body mass (VT:0001259)body weight gain (CMO:0000420)461697658103194791Rat
1549839Bw52Body weight QTL 520.0001body mass (VT:0001259)body weight gain (CMO:0000420)461697658115089733Rat
61418Pia5Pristane induced arthritis QTL 54.5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)462277855128289560Rat
6478743Anxrr40Anxiety related response QTL 400.83076defecation behavior trait (VT:0010462)defecation rate (CMO:0000998)462753847107753847Rat
6478772Anxrr49Anxiety related response QTL 490.15488defecation behavior trait (VT:0010462)defecation rate (CMO:0000998)462753847107753847Rat
6478684Anxrr30Anxiety related response QTL 300.00087defecation behavior trait (VT:0010462)defecation rate (CMO:0000998)462753847107753847Rat
631651Bp124Blood pressure QTL 1243arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)462879517107879517Rat
7394826Bw126Body weight QTL 1260.002body mass (VT:0001259)body weight gain (CMO:0000420)46293326987483707Rat
8552807Vie4Viral induced encephalitis QTL 47.3brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)46293350882490359Rat
70192BpQTLcluster5Blood pressure QTL cluster 54.183arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)462933508114921294Rat
70192BpQTLcluster5Blood pressure QTL cluster 54.183arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)462933508114921294Rat
70192BpQTLcluster5Blood pressure QTL cluster 54.183arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)462933508114921294Rat
70192BpQTLcluster5Blood pressure QTL cluster 54.183arterial blood pressure trait (VT:2000000)percent change in mean arterial blood pressure (CMO:0002035)462933508114921294Rat
70192BpQTLcluster5Blood pressure QTL cluster 54.183arterial blood pressure trait (VT:2000000)percent change in systolic blood pressure (CMO:0000747)462933508114921294Rat
70192BpQTLcluster5Blood pressure QTL cluster 54.183arterial blood pressure trait (VT:2000000)absolute change in pulse pressure (CMO:0001882)462933508114921294Rat
70192BpQTLcluster5Blood pressure QTL cluster 54.183arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)462933508114921294Rat
631674Iddm14Insulin dependent diabetes mellitus QTL 14blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)464528739157573521Rat

Markers in Region
D4Rat118  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2465,717,317 - 65,717,565 (+)MAPPERmRatBN7.2
Rnor_6.0464,679,412 - 64,679,659NCBIRnor6.0
Rnor_5.0464,502,357 - 64,502,604UniSTSRnor5.0
RGSC_v3.4464,507,593 - 64,507,841RGDRGSC3.4
RGSC_v3.4464,507,594 - 64,507,841UniSTSRGSC3.4
RGSC_v3.1464,783,723 - 64,783,971RGD
Celera460,746,336 - 60,746,575UniSTS
SHRSP x BN Map434.06RGD
SHRSP x BN Map434.06UniSTS
Cytogenetic Map4q22UniSTS
D4Rat135  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2465,720,681 - 65,720,843 (+)MAPPERmRatBN7.2
Rnor_6.0464,682,772 - 64,682,933NCBIRnor6.0
Rnor_5.0464,505,717 - 64,505,878UniSTSRnor5.0
RGSC_v3.4464,510,953 - 64,511,115RGDRGSC3.4
RGSC_v3.4464,510,954 - 64,511,115UniSTSRGSC3.4
RGSC_v3.1464,787,084 - 64,787,245RGD
Celera460,749,688 - 60,749,859UniSTS
RH 3.4 Map4412.7RGD
RH 3.4 Map4412.7UniSTS
SHRSP x BN Map434.0UniSTS
SHRSP x BN Map434.0RGD
FHH x ACI Map444.7199RGD
Cytogenetic Map4q22UniSTS
D4Got50  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2465,554,706 - 65,554,918 (+)MAPPERmRatBN7.2
Rnor_6.0464,518,305 - 64,518,516NCBIRnor6.0
Rnor_5.0464,340,830 - 64,341,041UniSTSRnor5.0
RGSC_v3.4464,341,328 - 64,341,540RGDRGSC3.4
RGSC_v3.4464,341,329 - 64,341,540UniSTSRGSC3.4
RGSC_v3.1464,617,458 - 64,617,670RGD
Celera460,584,618 - 60,584,829UniSTS
Cytogenetic Map4q22UniSTS
RH144498  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2465,420,251 - 65,420,435 (+)MAPPERmRatBN7.2
Rnor_6.0464,374,486 - 64,374,669NCBIRnor6.0
Rnor_5.0464,199,355 - 64,199,538UniSTSRnor5.0
RGSC_v3.4464,207,337 - 64,207,520UniSTSRGSC3.4
Celera460,450,648 - 60,450,831UniSTS
RH 3.4 Map4412.8UniSTS
Cytogenetic Map4q22UniSTS
BE102640  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2465,649,246 - 65,649,443 (+)MAPPERmRatBN7.2
Rnor_6.0464,611,731 - 64,611,927NCBIRnor6.0
Rnor_5.0464,434,651 - 64,434,847UniSTSRnor5.0
RGSC_v3.4464,436,884 - 64,437,080UniSTSRGSC3.4
Celera460,678,845 - 60,679,041UniSTS
RH 3.4 Map4414.8UniSTS
Cytogenetic Map4q22UniSTS
AU048384  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2465,538,376 - 65,538,654 (+)MAPPERmRatBN7.2
Rnor_6.0464,501,797 - 64,502,074NCBIRnor6.0
Rnor_5.0464,324,525 - 64,324,802UniSTSRnor5.0
RGSC_v3.4464,325,024 - 64,325,301UniSTSRGSC3.4
Celera460,568,284 - 60,568,561UniSTS
Cytogenetic Map4q22UniSTS


Related Rat Strains
The following Strains have been annotated to Dgki


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 60 4
Low 3 32 18 2 10 2 1 1 14 30 11 1
Below cutoff 11 8 8 8 8 7 7 29 7 7

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_198782 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006236333 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017592894 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039108367 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039108368 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039108369 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039108370 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039108371 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039108372 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039108374 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB058962 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB058963 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB058964 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AW526027 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CN544764 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JACYVU010000141 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000033268   ⟹   ENSRNOP00000034571
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl465,420,108 - 65,872,733 (-)Ensembl
Rnor_6.0 Ensembl464,374,342 - 64,831,473 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000079285   ⟹   ENSRNOP00000072665
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl465,587,308 - 65,872,733 (-)Ensembl
Rnor_6.0 Ensembl464,548,530 - 64,831,233 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000095496   ⟹   ENSRNOP00000097838
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl465,420,108 - 65,872,733 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000108173   ⟹   ENSRNOP00000093014
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl465,489,921 - 65,872,733 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000120235   ⟹   ENSRNOP00000079887
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl465,420,108 - 65,872,733 (-)Ensembl
RefSeq Acc Id: NM_198782   ⟹   NP_942077
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2465,420,107 - 65,872,733 (-)NCBI
Rnor_6.0464,374,341 - 64,831,473 (-)NCBI
Rnor_5.0464,193,188 - 64,653,936 (-)NCBI
RGSC_v3.4464,207,192 - 64,663,627 (-)RGD
Celera460,450,503 - 60,895,770 (-)RGD
Sequence:
RefSeq Acc Id: XM_006236333   ⟹   XP_006236395
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2465,410,878 - 65,872,527 (-)NCBI
Rnor_6.0464,365,115 - 64,831,285 (-)NCBI
Rnor_5.0464,193,188 - 64,653,936 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017592894   ⟹   XP_017448383
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2465,410,878 - 65,872,527 (-)NCBI
Rnor_6.0464,365,115 - 64,831,285 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039108367   ⟹   XP_038964295
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2465,410,878 - 65,872,528 (-)NCBI
RefSeq Acc Id: XM_039108368   ⟹   XP_038964296
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2465,410,878 - 65,872,528 (-)NCBI
RefSeq Acc Id: XM_039108369   ⟹   XP_038964297
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2465,410,878 - 65,872,527 (-)NCBI
RefSeq Acc Id: XM_039108370   ⟹   XP_038964298
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2465,410,878 - 65,872,528 (-)NCBI
RefSeq Acc Id: XM_039108371   ⟹   XP_038964299
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2465,410,878 - 65,872,528 (-)NCBI
RefSeq Acc Id: XM_039108372   ⟹   XP_038964300
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2465,584,827 - 65,872,532 (-)NCBI
RefSeq Acc Id: XM_039108374   ⟹   XP_038964302
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2465,584,830 - 65,872,529 (-)NCBI
Reference Sequences
RefSeq Acc Id: NP_942077   ⟸   NM_198782
- UniProtKB: F1MAB7 (UniProtKB/TrEMBL),   Q810C5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006236395   ⟸   XM_006236333
- Peptide Label: isoform X4
- UniProtKB: A0A8I5ZPA8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017448383   ⟸   XM_017592894
- Peptide Label: isoform X5
- Sequence:
RefSeq Acc Id: ENSRNOP00000072665   ⟸   ENSRNOT00000079285
RefSeq Acc Id: ENSRNOP00000034571   ⟸   ENSRNOT00000033268
RefSeq Acc Id: XP_038964299   ⟸   XM_039108371
- Peptide Label: isoform X7
RefSeq Acc Id: XP_038964298   ⟸   XM_039108370
- Peptide Label: isoform X6
RefSeq Acc Id: XP_038964296   ⟸   XM_039108368
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038964295   ⟸   XM_039108367
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038964297   ⟸   XM_039108369
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038964300   ⟸   XM_039108372
- Peptide Label: isoform X8
RefSeq Acc Id: XP_038964302   ⟸   XM_039108374
- Peptide Label: isoform X9
RefSeq Acc Id: ENSRNOP00000097838   ⟸   ENSRNOT00000095496
RefSeq Acc Id: ENSRNOP00000079887   ⟸   ENSRNOT00000120235
RefSeq Acc Id: ENSRNOP00000093014   ⟸   ENSRNOT00000108173
Protein Domains
DAGKc

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-F1MAB7-F1-model_v2 AlphaFold F1MAB7 1-1050 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:735049 AgrOrtholog
BioCyc Gene G2FUF-45224 BioCyc
Ensembl Genes ENSRNOG00000026705 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000034571 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOP00000072665 ENTREZGENE
  ENSRNOP00000072665.2 UniProtKB/TrEMBL
  ENSRNOP00000079887 ENTREZGENE
  ENSRNOP00000079887.1 UniProtKB/TrEMBL
  ENSRNOP00000093014.1 UniProtKB/TrEMBL
  ENSRNOP00000097838.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000033268 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOT00000079285 ENTREZGENE
  ENSRNOT00000079285.2 UniProtKB/TrEMBL
  ENSRNOT00000095496.1 UniProtKB/TrEMBL
  ENSRNOT00000108173.1 UniProtKB/TrEMBL
  ENSRNOT00000120235 ENTREZGENE
  ENSRNOT00000120235.1 UniProtKB/TrEMBL
Gene3D-CATH 1.25.40.20 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.40.50.10330 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Ankyrin_rpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ankyrin_rpt-contain_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ATP-NAD_kinase_dom_1 UniProtKB/TrEMBL, UniProtKB/Swiss-Prot
  ATP-NAD_kinase_PpnK-typ UniProtKB/TrEMBL
  DGK UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Diacylglycerol_kin_accessory UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Diacylglycerol_kinase_cat_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NAD/diacylglycerol_kinase_sf UniProtKB/Swiss-Prot
  PE/DAG-bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:688705 UniProtKB/Swiss-Prot
NCBI Gene 688705 ENTREZGENE
PANTHER PTHR11255 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Ank_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  C1_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DAGK_acc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DAGK_cat UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Dgki PhenoGen
PROSITE ANK_REP_REGION UniProtKB/Swiss-Prot
  ANK_REPEAT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DAGK UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART ANK UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DAGKa UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DAGKc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SM00109 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF111331 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF48403 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2K3J7_RAT UniProtKB/TrEMBL
  A0A8I5ZPA8 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AWF3_RAT UniProtKB/TrEMBL
  A0A8I6GM87_RAT UniProtKB/TrEMBL
  DGKI_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q810C5 ENTREZGENE
UniProt Secondary Q810C3 UniProtKB/Swiss-Prot
  Q810C4 UniProtKB/Swiss-Prot
  Q810C5 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-03-14 Dgki  diacylglycerol kinase, iota  LOC688705  similar to Diacylglycerol kinase iota (Diglyceride kinase iota) (DGK-iota) (DAG kinase iota)  Data Merged 737654 APPROVED
2006-11-19 LOC688705  similar to Diacylglycerol kinase iota (Diglyceride kinase iota) (DGK-iota) (DAG kinase iota)      Symbol and Name status set to provisional 70820 PROVISIONAL
2004-09-10 Dgki  diacylglycerol kinase, iota      Symbol and Name status set to approved 1299863 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_cellular_localization detected only in the cytoplasm of neuronal cells, despite the inclusion of a nuclear localization signal in the protein 1302915
gene_expression in Northern blot analysis, a major transcript of 3.3 kb was detected exclusively in brain and eye out of 11 tissues tested; testis showed only a shorter trascript (1.2 kb) of unknown origin 1302915
gene_expression in brain, in situ hybridization showed strong signals in the hippocampus, cerebellar cortex, olfactory bulb and olfactory tubercle, and moderate signals in cerebral cortex, caudate putamen and thalamus 1302915
gene_physical_interaction the reduced enzymatic activity of varient 2 appears to be due to a reduced affinity for ATP 1302915
gene_protein tanscript varient 1 codes for the full length Dgki protein; transcript varients 2 and 3 code for proteins which lack the C-terminal ankyrin repeats and varient 3 also lacks a portion of the DGK catalytic domain 1302915
gene_protein enzymatic activity of the protein encoded by transcript varient 2 is approximately half that of varient 1; activity of the varient 3 protein is essentially background 1302915
gene_transcript of 100 normal rat brain cDNA clones, 53% represented varient 1, 5% varient 2 and 42% varient 3 1302915
gene_transcript three transcript varients have been characterized in the brain; varients 2 and 3 contain 19 bp and 71 bp inserts, respectively, resulting in frameshift mutations which give rise to premature stop codons 1302915