RGD Reference Report - Development of Congenic Rat Strains for Alcohol Consumption Derived from the Alcohol-Preferring and Nonpreferring Rats. - Rat Genome Database

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Development of Congenic Rat Strains for Alcohol Consumption Derived from the Alcohol-Preferring and Nonpreferring Rats.

Authors: Carr, LG  Habegger, K  Spence, JP  Liu, L  Lumeng, L  Foroud, T 
Citation: Carr LG, etal., Behav Genet. 2006 Feb 10;:1-6.
RGD ID: 1578304
Pubmed: PMID:16470346   (View Abstract at PubMed)
DOI: DOI:10.1007/s10519-005-9021-z   (Journal Full-text)

A genome scan of the F2 generation from an inbred alcohol-preferring (iP) and inbred alcohol-nonpreferring (iNP) rat cross identified a significant quantitative trait locus (QTL) on chromosome 4 with a lod score of 9.2. To confirm this QTL and to create animals for fine mapping of the QTL region, chromosome 4 reciprocal congenic strains were developed by transferring the chromosome 4 QTL interval into the respective iP or iNP backgrounds. The iP strain was crossed with the iNP strain to create iPiNP F1 animals, which were backcrossed to either iNP or iP animals to produce the N2 generation. Using marker-assisted selection, 10 generations of backcrossing were performed. The selection was followed by an intercross between the N10 animals to produce homozygous animals (N10F1), resulting in the finished congenic strains. Congenic strains in which the iP chromosome 4 QTL interval was transferred to the iNP (NP.P) and the iNP chromosome 4 QTL was transferred to the iP (P.NP) exhibited the expected effect on alcohol consumption of the donor strain. Development of these congenic strains further indicates that the chromosome 4 QTL region is, in part, responsible for the disparate alcohol consumption observed between the iP and iNP rats. These congenic animals will be an invaluable resource for fine mapping the QTL region and for the identification of the gene(s) that influences the drinking behavior of the iP and iNP rats.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Alc21Ratalcohol use disorder  IAGP  RGD 
Alc22Ratalcohol use disorder  IAGP  RGD 
P.NP-(D4Rat119-D4Rat55)/IusmRatalcohol use disorder NOTIAGP  RGD 

Phenotype Annotations    Click to see Annotation Detail View

Mammalian Phenotype

Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
P.NP-(D4Rat119-D4Rat55)/IusmRatdecreased alcohol consumption  IAGP compared to P/IusmRGD 
Alc21Ratincreased alcohol consumption  IDA  RGD 
Alc22Ratincreased alcohol consumption  IDA  RGD 
NP.P-(D4Rat119-D4Rat55)/IusmRatincreased alcohol consumption  IAGP  RGD 

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Objects Annotated

QTLs
Alc21  (Alcohol consumption QTL 21)
Alc22  (Alcohol consumption QTL 22)

Objects referenced in this article
QTL Alc18 Alcohol consumption QTL 18 Rattus norvegicus
Strain Iusm:NP alcohol-nonpreferring Rattus norvegicus
Strain Iusm:P alcohol-preferring Rattus norvegicus

Additional Information