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Gene: Sos1 (SOS Ras/Rac guanine nucleotide exchange factor 1) Rattus norvegicus
Symbol: Sos1
Name: SOS Ras/Rac guanine nucleotide exchange factor 1
Description: Exhibits SH3 domain binding activity. Involved in Ras protein signal transduction; neurotrophin TRK receptor signaling pathway; and positive regulation of signal transduction. Localizes to the neuronal cell body; plasma membrane; and postsynaptic density. Human ortholog(s) of this gene implicated in Noonan syndrome; Noonan syndrome 4; and gingival fibromatosis. Orthologous to human SOS1 (SOS Ras/Rac guanine nucleotide exchange factor 1); PARTICIPATES IN epidermal growth factor/neuregulin signaling pathway; insulin signaling pathway; nerve growth factor signaling pathway; INTERACTS WITH (S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: LOC313845; Son of sevenless homolog 1; Son of sevenless homolog 1 (Drosophila)
Is Marker For: Strains:   NP.P-(D4Rat119-D4Rat55)/Iusm  
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
NCBI Annotation Information: Annotation category: suggests misassembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.063,105,443 - 3,182,977 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.063,082,456 - 3,159,445 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.463,308,778 - 3,390,661 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.163,310,822 - 3,394,313 (-)NCBI
Celera614,210,655 - 14,287,471 (+)NCBICelera
Cytogenetic Map6q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Candidate Gene Status
Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
Related Rat Strains
miRNA Target Status


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 5.0)

Additional Information

External Database Links
Nomenclature History
More on Sos1
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1310949
Created: 2005-01-12
Species: Rattus norvegicus
Last Modified: 2019-08-20
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.