Sos1 (SOS Ras/Rac guanine nucleotide exchange factor 1) - Rat Genome Database

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Gene: Sos1 (SOS Ras/Rac guanine nucleotide exchange factor 1) Rattus norvegicus
Analyze
Symbol: Sos1
Name: SOS Ras/Rac guanine nucleotide exchange factor 1
RGD ID: 1310949
Description: Enables SH3 domain binding activity and epidermal growth factor receptor binding activity. Involved in several processes, including Ras protein signal transduction; neurotrophin TRK receptor signaling pathway; and positive regulation of signal transduction. Located in neuronal cell body. Is active in glutamatergic synapse and postsynaptic density. Used to study brain ischemia. Human ortholog(s) of this gene implicated in Noonan syndrome; Noonan syndrome 4; atrial heart septal defect; gingival fibromatosis; and pulmonary valve stenosis. Orthologous to human SOS1 (SOS Ras/Rac guanine nucleotide exchange factor 1); PARTICIPATES IN epidermal growth factor/neuregulin signaling pathway; insulin signaling pathway; nerve growth factor signaling pathway; INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 3-chloropropane-1,2-diol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC313845; Son of sevenless homolog 1; Son of sevenless homolog 1 (Drosophila)
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Is Marker For: Strains:   NP.P-(D4Rat119-D4Rat55)/Iusm  
Candidate Gene For: Alc22
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8620,286,117 - 20,363,350 (+)NCBIGRCr8
mRatBN7.2614,533,870 - 14,613,348 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl614,533,360 - 14,611,107 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx614,832,784 - 14,910,104 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0615,154,472 - 15,231,727 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0614,650,751 - 14,727,998 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.063,105,443 - 3,182,977 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl63,104,861 - 3,182,996 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.063,082,456 - 3,159,445 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.463,308,778 - 3,390,661 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.163,310,822 - 3,394,313 (-)NCBI
Celera614,210,655 - 14,287,471 (+)NCBICelera
Cytogenetic Map6q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-Tetrandrine  (ISO)
(S)-nicotine  (ISO)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-hydroxypropanoic acid  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,3',4,4'-tetrachlorobiphenyl  (ISO)
3-chloropropane-1,2-diol  (EXP)
3-methylcholanthrene  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-diaminodiphenylmethane  (ISO)
4-nitrophenol  (ISO)
actinomycin D  (ISO)
aflatoxin B1  (ISO)
aflatoxin M1  (ISO)
allyl isothiocyanate  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
atrazine  (ISO)
benzo[a]pyrene  (ISO)
benzo[e]pyrene  (ISO)
bisdemethoxycurcumin  (ISO)
bisphenol A  (EXP,ISO)
bufalin  (ISO)
butanal  (ISO)
caffeine  (ISO)
cannabidiol  (ISO)
carbamazepine  (ISO)
casticin  (ISO)
CGP 52608  (ISO)
chrysin  (ISO)
clozapine  (EXP)
copper atom  (ISO)
copper(0)  (ISO)
coumarin  (ISO)
crocidolite asbestos  (ISO)
cycloheximide  (ISO)
D-glucose  (ISO)
DDT  (ISO)
deguelin  (ISO)
diclofenac  (ISO)
dioxygen  (ISO)
diuron  (ISO)
doxorubicin  (ISO)
dutasteride  (ISO)
elemental selenium  (ISO)
enzyme inhibitor  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
FR900359  (ISO)
fulvestrant  (ISO)
GDP  (ISO)
glyphosate  (ISO)
GTP  (ISO)
hydrogen peroxide  (ISO)
leflunomide  (ISO)
Mecamylamine  (ISO)
mercury atom  (ISO)
mercury(0)  (ISO)
methapyrilene  (ISO)
methylmercury chloride  (ISO)
miconazole  (ISO)
N-methyl-N-nitrosourea  (EXP)
nickel atom  (ISO)
nicotine  (ISO)
ouabain  (ISO)
oxaliplatin  (EXP)
ozone  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
potassium dichromate  (ISO)
progesterone  (EXP)
protein kinase inhibitor  (ISO)
quercetin  (ISO)
rac-lactic acid  (ISO)
resveratrol  (ISO)
selenium atom  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
testosterone enanthate  (ISO)
thioacetamide  (EXP)
topotecan  (EXP)
trimethyltin  (ISO)
triphenyl phosphate  (ISO)
Triptolide  (ISO)
troglitazone  (ISO)
tubocurarine  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vincristine  (ISO)
vitamin E  (ISO)
vorinostat  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Local phosphatidylinositol 3,4,5-trisphosphate accumulation recruits Vav2 and Vav3 to activate Rac1/Cdc42 and initiate neurite outgrowth in nerve growth factor-stimulated PC12 cells. Aoki K, etal., Mol Biol Cell. 2005 May;16(5):2207-17. Epub 2005 Feb 23.
2. Comprehensive transcriptome analysis identifies pathways with therapeutic potential in locally advanced cervical cancer. Campos-Parra AD, etal., Gynecol Oncol. 2016 Nov;143(2):406-413. doi: 10.1016/j.ygyno.2016.08.327. Epub 2016 Aug 28.
3. Activation of multiple signaling pathways causes developmental defects in mice with a Noonan syndrome-associated Sos1 mutation. Chen PC, etal., J Clin Invest. 2010 Dec;120(12):4353-65. doi: 10.1172/JCI43910.
4. The role of the PH domain in the signal-dependent membrane targeting of Sos. Chen RH, etal., EMBO J. 1997 Mar 17;16(6):1351-9.
5. EGF-ERBB signalling: towards the systems level. Citri A and Yarden Y, Nat Rev Mol Cell Biol. 2006 Jul;7(7):505-16.
6. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
7. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
8. A mutation in the SOS1 gene causes hereditary gingival fibromatosis type 1. Hart TC, etal., Am J Hum Genet. 2002 Apr;70(4):943-54. Epub 2002 Feb 26.
9. Insulin signaling through insulin receptor substrate 1 and 2 in normal liver development. Khamzina L, etal., Gastroenterology 2003 Aug;125(2):572-85.
10. Direct interaction of SOS1 Ras exchange protein with the SH3 domain of phospholipase C-gamma1. Kim MJ, etal., Biochemistry. 2000 Jul 25;39(29):8674-82.
11. Noonan syndrome associated with both a new Jnk-activating familial SOS1 and a de novo RAF1 mutations. Longoni M, etal., Am J Med Genet A. 2010 Sep;152A(9):2176-84. doi: 10.1002/ajmg.a.33564.
12. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
13. IL-6/IL-6 receptor system and its role in physiological and pathological conditions. Mihara M, etal., Clin Sci (Lond). 2012 Feb;122(4):143-59. doi: 10.1042/CS20110340.
14. Adaptor Protein p66Shc: A Link Between Cytosolic and Mitochondrial Dysfunction in the Development of Diabetic Retinopathy. Mishra M, etal., Antioxid Redox Signal. 2019 May 1;30(13):1621-1634. doi: 10.1089/ars.2018.7542. Epub 2018 Oct 3.
15. Blockade of mitogen-activated protein kinase cascade signaling in interleukin 6-independent multiple myeloma cells. Ogata A, etal., Clin Cancer Res. 1997 Jun;3(6):1017-22.
16. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
17. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
18. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
19. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
20. Knockdown of circRNA-Memo1 Reduces Hypoxia/Reoxygenation Injury in Human Brain Endothelial Cells Through miRNA-17-5p/SOS1 Axis. Ren X, etal., Mol Neurobiol. 2022 Apr;59(4):2085-2097. doi: 10.1007/s12035-022-02743-4. Epub 2022 Jan 18.
21. GOA pipeline RGD automated data pipeline
22. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
23. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
24. Germline gain-of-function mutations in SOS1 cause Noonan syndrome. Roberts AE, etal., Nat Genet. 2007 Jan;39(1):70-4. Epub 2006 Dec 3.
25. Stimulation of growth factor receptor signal transduction by activation of voltage-sensitive calcium channels. Rosen LB and Greenberg ME, Proc Natl Acad Sci U S A. 1996 Feb 6;93(3):1113-8.
26. Src-dependent TrkA transactivation is required for pituitary adenylate cyclase-activating polypeptide 38-mediated Rit activation and neuronal differentiation. Shi GX, etal., Mol Biol Cell. 2010 May 1;21(9):1597-608. Epub 2010 Mar 10.
27. Presence of up-stream and downstream components of a mitogen-activated protein kinase pathway in the PSD of the rat forebrain. Suzuki T, etal., Brain Res. 1999 Sep 4;840(1-2):36-44.
28. Gain-of-function SOS1 mutations cause a distinctive form of Noonan syndrome. Tartaglia M, etal., Nat Genet. 2007 Jan;39(1):75-9. Epub 2006 Dec 13.
29. Enhanced expression of SOS1 is detected in prostate cancer epithelial cells from African-American men. Timofeeva OA, etal., Int J Oncol. 2009 Oct;35(4):751-60.
30. SOS1 is the second most common Noonan gene but plays no major role in cardio-facio-cutaneous syndrome. Zenker M, etal., J Med Genet. 2007 Oct;44(10):651-6. Epub 2007 Jun 23.
31. Crosstalk Between MAPK/ERK and PI3K/AKT Signal Pathways During Brain Ischemia/Reperfusion. Zhou J, etal., ASN Neuro. 2015 Oct 6;7(5). pii: 7/5/1759091415602463. doi: 10.1177/1759091415602463. Print 2015 Sep-Oct.
Additional References at PubMed
PMID:1371879   PMID:7731718   PMID:9030684   PMID:10206341   PMID:11352907   PMID:11585837   PMID:12008030   PMID:12477932   PMID:15644420   PMID:16203968   PMID:16483568   PMID:17515907  
PMID:17721087   PMID:21118970   PMID:24043312  


Genomics

Comparative Map Data
Sos1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8620,286,117 - 20,363,350 (+)NCBIGRCr8
mRatBN7.2614,533,870 - 14,613,348 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl614,533,360 - 14,611,107 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx614,832,784 - 14,910,104 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0615,154,472 - 15,231,727 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0614,650,751 - 14,727,998 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.063,105,443 - 3,182,977 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl63,104,861 - 3,182,996 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.063,082,456 - 3,159,445 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.463,308,778 - 3,390,661 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.163,310,822 - 3,394,313 (-)NCBI
Celera614,210,655 - 14,287,471 (+)NCBICelera
Cytogenetic Map6q12NCBI
SOS1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38238,981,549 - 39,124,868 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl238,962,206 - 39,124,345 (-)EnsemblGRCh38hg38GRCh38
GRCh37239,208,690 - 39,352,009 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36239,066,469 - 39,201,067 (-)NCBINCBI36Build 36hg18NCBI36
Build 34239,124,615 - 39,259,214NCBI
Celera239,049,411 - 39,188,687 (-)NCBICelera
Cytogenetic Map2p22.1NCBI
HuRef238,947,128 - 39,086,120 (-)NCBIHuRef
CHM1_1239,139,128 - 39,278,182 (-)NCBICHM1_1
T2T-CHM13v2.0238,990,066 - 39,133,839 (-)NCBIT2T-CHM13v2.0
Sos1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391780,701,181 - 80,787,882 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1780,701,180 - 80,787,882 (-)EnsemblGRCm39 Ensembl
GRCm381780,393,752 - 80,480,453 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1780,393,751 - 80,480,453 (-)EnsemblGRCm38mm10GRCm38
MGSCv371780,793,092 - 80,879,793 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361780,305,779 - 80,388,265 (-)NCBIMGSCv36mm8
Celera1784,712,016 - 84,797,777 (-)NCBICelera
Cytogenetic Map17E3NCBI
cM Map1750.67NCBI
Sos1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554416,646,385 - 6,713,028 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554416,649,895 - 6,724,271 (-)NCBIChiLan1.0ChiLan1.0
SOS1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21287,342,622 - 87,487,223 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12A87,346,597 - 87,488,030 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02A39,019,046 - 39,162,248 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12A39,773,758 - 39,911,964 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A39,773,760 - 39,911,961 (-)Ensemblpanpan1.1panPan2
SOS1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11731,007,940 - 31,181,569 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1731,009,257 - 31,142,063 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1730,825,007 - 30,830,255 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01731,664,627 - 31,805,012 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1731,664,631 - 31,805,021 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11730,886,361 - 31,025,725 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01730,956,021 - 31,095,889 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01731,169,723 - 31,309,388 (-)NCBIUU_Cfam_GSD_1.0
Sos1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629240,733,944 - 40,853,206 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493650812,162,547 - 12,281,820 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493650812,162,553 - 12,281,812 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SOS1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl3101,209,641 - 101,362,723 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.13101,209,568 - 101,366,057 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.23107,318,421 - 107,466,093 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SOS1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11468,259,509 - 68,404,167 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1468,259,360 - 68,399,895 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604543,577,050 - 43,723,991 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Sos1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473820,466,117 - 20,591,910 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473820,466,120 - 20,591,966 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Sos1
309 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:654
Count of miRNA genes:272
Interacting mature miRNAs:347
Transcripts:ENSRNOT00000009359
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4145119Mcs25Mammary carcinoma susceptibility QTL 250.0001mammary gland integrity trait (VT:0010552)ratio of deaths to total study population during a period of time (CMO:0001023)610894415110548006Rat
7411603Foco13Food consumption QTL 135.50.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)6141223769Rat
738023Alc17Alcohol consumption QTL 173.10.003consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)6127574569Rat
738024Sach5Saccharine consumption QTL 53.90.00039consumption behavior trait (VT:0002069)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)6143394190Rat
7411584Foco4Food consumption QTL 44.30.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)6142838846Rat
8552962Pigfal16Plasma insulin-like growth factor 1 level QTL 169.4blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)6141223769Rat
7411542Bw127Body weight QTL 1275.50.001body mass (VT:0001259)body weight gain (CMO:0000420)6141223769Rat
9589129Insul24Insulin level QTL 2419.060.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)6141223769Rat
1300128Rf16Renal function QTL 163.89renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)6507449734434305Rat
1331743Uae28Urinary albumin excretion QTL 284.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)6134235784Rat
9589048Scfw3Subcutaneous fat weight QTL 34.570.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)6141223769Rat
10401812Kidm54Kidney mass QTL 54kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)61436878859368788Rat
1300164Rf15Renal function QTL 153.12renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)6507449754641141Rat
1354616Despr12Despair related QTL 120.0012locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)6127574569Rat
1549905Stresp10Stress response QTL 106.830.0066stress-related behavior trait (VT:0010451)number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)6127574569Rat
1358190Ept1Estrogen-induced pituitary tumorigenesis QTL 14.4pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)6984331220338915Rat
1578758Tcas9Tongue tumor susceptibility QTL 93.29tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)6137618905Rat
1578665Bss16Bone structure and strength QTL 164.4femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)61173566972593685Rat
1578668Bmd14Bone mineral density QTL 143.8femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)61173566972593685Rat
2292616Ept15Estrogen-induced pituitary tumorigenesis QTL 154.4pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)6984331220338915Rat
2301972Bp325Blood pressure QTL 3254.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)6172227641Rat
2300190Bmd52Bone mineral density QTL 5211.20.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)6127574569Rat
1598843Cm63Cardiac mass QTL 632.6heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)6139036266Rat
2293709Bss23Bone structure and strength QTL 235.180.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)6142487980Rat
2293706Bmd20Bone mineral density QTL 204.30.0002femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)6507449719988050Rat
2300176Bmd51Bone mineral density QTL 5111.70.0001femur mineral mass (VT:0010011)bone mineral density (CMO:0001226)6127574569Rat
2293656Bss28Bone structure and strength QTL 286.790.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)6142487980Rat
10401800Kidm49Kidney mass QTL 49kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)61436878859368788Rat
2293650Bss31Bone structure and strength QTL 315.050.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)6142487980Rat

Markers in Region
18.MMHAP91FRF9.seq  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2614,533,047 - 14,533,232 (-)MAPPERmRatBN7.2
Rnor_6.063,183,615 - 3,183,799NCBIRnor6.0
Rnor_5.063,160,083 - 3,160,267UniSTSRnor5.0
RGSC_v3.463,391,320 - 3,391,504UniSTSRGSC3.4
Celera614,209,839 - 14,210,023UniSTS
Cytogenetic Map6q11UniSTS
BE097889  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2614,559,727 - 14,559,890 (-)MAPPERmRatBN7.2
Rnor_6.063,156,791 - 3,156,953NCBIRnor6.0
Rnor_5.063,133,259 - 3,133,421UniSTSRnor5.0
RGSC_v3.463,361,747 - 3,361,909UniSTSRGSC3.4
Celera614,236,212 - 14,236,374UniSTS
RH 3.4 Map646.4UniSTS
Cytogenetic Map6q11UniSTS
RH134803  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2614,609,848 - 14,610,030 (-)MAPPERmRatBN7.2
Rnor_6.063,106,520 - 3,106,701NCBIRnor6.0
Rnor_5.063,083,533 - 3,083,714UniSTSRnor5.0
RGSC_v3.463,309,855 - 3,310,036UniSTSRGSC3.4
Celera614,286,213 - 14,286,394UniSTS
Cytogenetic Map6q11UniSTS
RH137866  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2614,578,630 - 14,578,750 (-)MAPPERmRatBN7.2
Rnor_6.063,138,035 - 3,138,154NCBIRnor6.0
Rnor_5.063,114,690 - 3,114,809UniSTSRnor5.0
RGSC_v3.463,343,333 - 3,343,452UniSTSRGSC3.4
Celera614,255,112 - 14,255,231UniSTS
Cytogenetic Map6q11UniSTS
UniSTS:237713  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2614,532,835 - 14,533,067 (-)MAPPERmRatBN7.2
Rnor_6.063,183,780 - 3,184,011NCBIRnor6.0
Rnor_5.063,160,248 - 3,160,479UniSTSRnor5.0
RGSC_v3.463,391,485 - 3,391,716UniSTSRGSC3.4
Cytogenetic Map6q11UniSTS
D2S1690E  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2614,588,094 - 14,589,343 (-)MAPPERmRatBN7.2
Rnor_6.063,127,438 - 3,128,686NCBIRnor6.0
Rnor_5.063,104,093 - 3,105,341UniSTSRnor5.0
RGSC_v3.463,333,156 - 3,334,404UniSTSRGSC3.4
Celera614,264,576 - 14,265,824UniSTS
Cytogenetic Map6q11UniSTS


Related Rat Strains
The following Strains have been annotated to Sos1


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 26 40 24 19 24 74 28 35 11
Low 17 17 17 17 8 11 7 6 8
Below cutoff

Sequence


RefSeq Acc Id: ENSRNOT00000009359   ⟹   ENSRNOP00000009359
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl614,533,870 - 14,611,107 (+)Ensembl
Rnor_6.0 Ensembl63,104,861 - 3,182,996 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000116736   ⟹   ENSRNOP00000096553
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl614,533,360 - 14,611,107 (+)Ensembl
RefSeq Acc Id: NM_001100716   ⟹   NP_001094186
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8620,286,117 - 20,363,350 (+)NCBI
mRatBN7.2614,533,870 - 14,611,107 (+)NCBI
Rnor_6.063,105,443 - 3,182,977 (-)NCBI
Rnor_5.063,082,456 - 3,159,445 (-)NCBI
RGSC_v3.463,308,778 - 3,390,661 (-)RGD
Celera614,210,655 - 14,287,471 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001094186 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAI00643 (Get FASTA)   NCBI Sequence Viewer  
  EDM02758 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000009359
  ENSRNOP00000009359.6
  ENSRNOP00000096553.1
RefSeq Acc Id: NP_001094186   ⟸   NM_001100716
- UniProtKB: D4A3T0 (UniProtKB/TrEMBL),   A6H9Q3 (UniProtKB/TrEMBL),   A0A8I6B4D6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000009359   ⟸   ENSRNOT00000009359
RefSeq Acc Id: ENSRNOP00000096553   ⟸   ENSRNOT00000116736
Protein Domains
DH   N-terminal Ras-GEF   PH   Ras-GEF

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D4A3T0-F1-model_v2 AlphaFold D4A3T0 1-1319 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1310949 AgrOrtholog
BioCyc Gene G2FUF-38528 BioCyc
Ensembl Genes ENSRNOG00000007106 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000009359 ENTREZGENE
  ENSRNOT00000009359.8 UniProtKB/TrEMBL
  ENSRNOT00000116736.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.20.10 UniProtKB/TrEMBL
  1.10.840.10 UniProtKB/TrEMBL
  1.20.900.10 UniProtKB/TrEMBL
  2.30.29.30 UniProtKB/TrEMBL
  6.10.250.3060 UniProtKB/TrEMBL
  Son of sevenless (SoS) protein Chain: S domain 1 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7930046 IMAGE-MGC_LOAD
InterPro DBL_dom_sf UniProtKB/TrEMBL
  DH-domain UniProtKB/TrEMBL
  Histone-fold UniProtKB/TrEMBL
  PH_type UniProtKB/TrEMBL
  Pleckstrin_homology UniProtKB/TrEMBL
  Ras-like_GEF UniProtKB/TrEMBL
  Ras-like_Gua-exchang_fac_N UniProtKB/TrEMBL
  Ras_G-nucl-exch_fac_CS UniProtKB/TrEMBL
  Ras_GEF_dom UniProtKB/TrEMBL
  RASGEF_cat_dom_sf UniProtKB/TrEMBL
  RasGRF_CDC25 UniProtKB/TrEMBL
KEGG Report rno:313845 UniProtKB/TrEMBL
MGC_CLONE MGC:124890 IMAGE-MGC_LOAD
NCBI Gene 313845 ENTREZGENE
PANTHER PTHR23113 UniProtKB/TrEMBL
  SON OF SEVENLESS HOMOLOG 1 UniProtKB/TrEMBL
Pfam PF00169 UniProtKB/TrEMBL
  RasGEF UniProtKB/TrEMBL
  RasGEF_N UniProtKB/TrEMBL
  RhoGEF UniProtKB/TrEMBL
PhenoGen Sos1 PhenoGen
PROSITE DH_2 UniProtKB/TrEMBL
  PH_DOMAIN UniProtKB/TrEMBL
  RASGEF UniProtKB/TrEMBL
  RASGEF_CAT UniProtKB/TrEMBL
  RASGEF_NTER UniProtKB/TrEMBL
RatGTEx ENSRNOG00000007106 RatGTEx
SMART RasGEF UniProtKB/TrEMBL
  RasGEFN UniProtKB/TrEMBL
  RhoGEF UniProtKB/TrEMBL
  SM00233 UniProtKB/TrEMBL
Superfamily-SCOP DH-domain UniProtKB/TrEMBL
  Histone-fold UniProtKB/TrEMBL
  PH domain-like UniProtKB/TrEMBL
  Ras_GEF UniProtKB/TrEMBL
UniProt A0A8I6B4D6 ENTREZGENE, UniProtKB/TrEMBL
  A6H9Q3 ENTREZGENE, UniProtKB/TrEMBL
  D4A3T0 ENTREZGENE, UniProtKB/TrEMBL
  Q497A5_RAT UniProtKB/TrEMBL
  Q9Z1I1_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-11-20 Sos1  SOS Ras/Rac guanine nucleotide exchange factor 1  Sos1  Son of sevenless homolog 1 (Drosophila)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-12-06 Sos1  Son of sevenless homolog 1 (Drosophila)  Sos1_predicted  Son of sevenless homolog 1 (Drosophila) (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Sos1_predicted  Son of sevenless homolog 1 (Drosophila) (predicted)      Symbol and Name status set to approved 70820 APPROVED