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Gene: Akr1b1 (aldo-keto reductase family 1 member B) Rattus norvegicus
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Symbol: Akr1b1
Name: aldo-keto reductase family 1 member B
Description: Exhibits alditol:NADP+ 1-oxidoreductase activity. Involved in several processes, including inner medullary collecting duct development; positive regulation of smooth muscle cell proliferation; and sorbitol biosynthetic process. Localizes to several cellular components, including the Schmidt-Lanterman incisure; cytoplasm; and extracellular space. Used to study allergic hypersensitivity disease; arteriosclerosis; cataract; diabetic neuropathy; and diabetic retinopathy. Biomarker of diabetic retinopathy; galactosemia; hepatocellular carcinoma; hyperglycemia; and hypokalemia. Human ortholog(s) of this gene implicated in arteriosclerosis; cataract; diabetic neuropathy; diabetic retinopathy; and type 2 diabetes mellitus. Orthologous to human AKR1B1 (aldo-keto reductase family 1 member B); PARTICIPATES IN polyol pathway; altered galactose metabolic pathway; D-glycericacidemia pathway; INTERACTS WITH (+)-alpha-tocopherol; (S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE; 1-naphthyl isothiocyanate.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: Akr1b3; Akr1b4; Aldehyde reductase 1 (low Km aldose reductase) (5.8 kb PstI fragment, probably the functional gene); aldo-keto reductase family 1 member B1; aldo-keto reductase family 1 member B1 (aldose reductase); aldo-keto reductase family 1, member B1 (aldose reductase); aldo-keto reductase family 1, member B4 (aldose reductase); aldose reductase; Aldr1; ALDRED; Alr; ALR-P-I; AR; RATALDRED
Orthologs:
Homo sapiens (human) : AKR1B1 (aldo-keto reductase family 1 member B)  HGNC  Alliance
Mus musculus (house mouse) : Akr1b3 (aldo-keto reductase family 1, member B3 (aldose reductase))  MGI  Alliance
Pan paniscus (bonobo/pygmy chimpanzee) : AKR1B1 (aldo-keto reductase family 1 member B)
Canis lupus familiaris (dog) : AKR1B1 (aldo-keto reductase family 1 member B)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Akr1b1 (aldo-keto reductase family 1 member B)
Sus scrofa (pig) : AKR1B1 (aldo-keto reductase family 1 member B)
more info ...
Related Pseudogenes: Akr1b1-ps1   Akr1b1-ps2   Akr1b1-ps3  
Is Marker For: Strains:   NP.P-(D4Rat119-D4Rat55)/Iusm  
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0461,706,866 - 61,720,959 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0461,426,190 - 61,440,279 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4461,645,438 - 61,659,530 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1461,921,567 - 61,935,660 (-)NCBI
Celera457,984,561 - 57,998,653 (-)NCBICelera
Cytogenetic Map4q22NCBI
RH 3.4 Map4393.32RGD
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Candidate Gene Status
Comparative Map Data
QTLs in Region (Rnor_6.0)
Related Rat Strains
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 6.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Akr1b1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 2092
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2019-08-20
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.