Akr1b1 (aldo-keto reductase family 1 member B1) - Rat Genome Database

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Gene: Akr1b1 (aldo-keto reductase family 1 member B1) Rattus norvegicus
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Symbol: Akr1b1
Name: aldo-keto reductase family 1 member B1
RGD ID: 2092
Description: Enables aldose reductase (NADPH) activity and cis-1,2-dihydro-1,2-dihydroxynaphthalene dehydrogenase activity. Involved in several processes, including cellular response to peptide; inner medullary collecting duct development; and sorbitol biosynthetic process. Located in several cellular components, including Schmidt-Lanterman incisure; Schwann cell microvillus; and mast cell granule. Used to study allergic disease; cataract; diabetic neuropathy; and diabetic retinopathy. Biomarker of diabetic retinopathy; galactosemia; hepatocellular carcinoma; hyperglycemia; and hypokalemia. Human ortholog(s) of this gene implicated in arteriosclerosis; cataract; diabetic neuropathy; diabetic retinopathy; and type 2 diabetes mellitus. Orthologous to human AKR1B1 (aldo-keto reductase family 1 member B); PARTICIPATES IN polyol pathway; altered galactose metabolic pathway; D-glycericacidemia pathway; INTERACTS WITH (R,R,R)-alpha-tocopherol; 1-naphthyl isothiocyanate; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: Akr1b3; Akr1b4; Aldehyde reductase 1 (low Km aldose reductase) (5.8 kb PstI fragment, probably the functional gene); aldo-keto reductase family 1 member B; aldo-keto reductase family 1 member B1 (aldose reductase); aldo-keto reductase family 1, member B1 (aldose reductase); aldo-keto reductase family 1, member B4 (aldose reductase); aldose reductase; Aldr1; ALDRED; Alr; ALR-P-I; AR; RATALDRED
RGD Orthologs
Human
Mouse
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Related Pseudogenes: Akr1b1-ps1   Akr1b1-ps2   Akr1b1-ps3  
Is Marker For: Strains:   NP.P-(D4Rat119-D4Rat55)/Iusm  
Candidate Gene For: Alc22
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8463,899,222 - 63,913,315 (-)NCBIGRCr8
GRCr8 Ensembl463,899,222 - 63,913,315 (-)EnsemblGRCr8 Ensembl
mRatBN7.2462,932,033 - 62,946,126 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl462,932,031 - 62,946,157 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx467,882,584 - 67,896,684 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0463,798,307 - 63,812,409 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0462,200,710 - 62,214,808 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0461,706,866 - 61,720,959 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl461,706,864 - 61,720,956 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0461,426,190 - 61,440,279 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4461,645,438 - 61,659,530 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera457,984,561 - 57,998,653 (-)NCBICelera
RGSC_v3.1461,921,567 - 61,935,660 (-)NCBI
RH 3.4 Map4393.32RGD
Cytogenetic Map4q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
(4-oxo-3-\{[5-(trifluoromethyl)-1,3-benzothiazol-2-yl]methyl\}-3,4-dihydrophthalazin-1-yl)acetic acid  (ISO)
(E)-cinnamyl alcohol  (ISO)
(E,E)-2,4-hexadienal  (ISO)
(R)-acetoin  (ISO)
(R,R,R)-alpha-tocopherol  (EXP)
1,2-dimethylhydrazine  (ISO)
1,2-naphthoquinone  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
1-naphthyl isothiocyanate  (EXP)
16-Ketoestrone  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3-dimethoxynaphthalene-1,4-dione  (ISO)
2,4-Nonadienal  (ISO)
2-acetamidofluorene  (ISO)
2-hexenal  (ISO)
2-hydroxypropanoic acid  (ISO)
2-palmitoylglycerol  (ISO)
2-pentenal  (ISO)
3,4-dihydroxybenzoic acid  (ISO)
3-chloropropane-1,2-diol  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-nitrobenzaldehyde  (ISO)
4,4'-diaminodiphenylmethane  (EXP,ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxy-2-octenal  (ISO)
4-hydroxyhexenal  (ISO)
4-hydroxynon-2-enal  (ISO)
4-hydroxyphenyl retinamide  (ISO)
4-nitrobenzaldehyde  (ISO)
7,9-dihydro-1H-purine-2,6,8(3H)-trione  (ISO)
9,10-phenanthroquinone  (ISO)
acetamide  (EXP)
acetoin  (ISO)
acrolein  (ISO)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-4-oxoretinal  (ISO)
all-trans-dehydroretinal  (ISO)
all-trans-retinal  (ISO)
all-trans-retinoic acid  (ISO)
all-trans-retinol  (ISO)
alpha-D-galactose  (ISO)
alpha-hexylcinnamaldehyde  (ISO)
alpha-Zearalanol  (EXP)
ammonium chloride  (EXP)
anthra[1,9-cd]pyrazol-6(2H)-one  (EXP)
antimony(0)  (ISO)
antimycin A  (ISO)
apocynin  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
Azoxymethane  (ISO)
azoxystrobin  (ISO)
Bandrowski's base  (ISO)
benzo[a]pyrene  (EXP,ISO)
Benzo[a]pyrene-7,8-diol  (ISO)
benzo[a]pyrene-7,8-dione  (ISO)
benzo[b]fluoranthene  (ISO)
Benzo[k]fluoranthene  (ISO)
benzoic acid  (ISO)
benzyl alcohol  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
bortezomib  (ISO)
butanal  (ISO)
butane-2,3-diol  (ISO)
butane-2,3-dione  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
candesartan  (EXP)
capecitabine  (ISO)
carbon nanotube  (ISO)
carboplatin  (EXP)
carmustine  (ISO)
cefaloridine  (EXP)
ceruletide  (EXP)
CGP 52608  (ISO)
chlordecone  (ISO)
choline  (ISO)
chromium atom  (ISO)
chromium(6+)  (ISO)
cinnamyl alcohol  (ISO)
cisplatin  (EXP,ISO)
clobetasol  (ISO)
Clofop  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) chloride  (ISO)
crocidolite asbestos  (ISO)
crotonaldehyde  (ISO)
curcumin  (EXP,ISO)
cyclosporin A  (ISO)
D-glucitol  (ISO)
D-glucose  (ISO)
D-glyceraldehyde  (ISO)
daunorubicin  (ISO)
DDE  (ISO)
decanal  (ISO)
deguelin  (ISO)
dexamethasone  (ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (ISO)
dibenz[a,h]anthracene  (EXP,ISO)
dibenzo[a,l]pyrene  (EXP)
dibutyl phthalate  (EXP)
dioxygen  (EXP,ISO)
dipotassium bis[mu-tartrato(4-)]diantimonate(2-) trihydrate  (ISO)
diquat  (ISO)
disulfiram  (ISO)
diuron  (EXP,ISO)
dorsomorphin  (ISO)
doxifluridine  (ISO)
doxorubicin  (EXP,ISO)
endosulfan  (EXP)
enzyme inhibitor  (ISO)
ethanol  (EXP,ISO)
eugenol  (ISO)
fenpyroximate  (ISO)
Fidarestat  (ISO)
fipronil  (EXP)
fluoranthene  (EXP,ISO)
flutamide  (EXP)
folic acid  (ISO)
fonofos  (ISO)
fructosamine  (ISO)
fructose  (EXP)
galactose  (ISO)
gentamycin  (EXP)
glucose  (ISO)
glutathione  (ISO)
glyceraldehyde  (ISO)
glycine betaine  (EXP)
glyoxal  (ISO)
glyphosate  (EXP)
hept-2-enal  (ISO)
heptanal  (ISO)
hexanal  (ISO)
hexane  (ISO)
hexane-2,3-dione  (ISO)
hypochlorous acid  (ISO)
indometacin  (ISO)
inulin  (ISO)
isatin  (ISO)
isoeugenol  (ISO)
ivermectin  (ISO)
L-ascorbic acid  (ISO)
L-methionine  (ISO)
lead diacetate  (ISO)
lipopolysaccharide  (ISO)
LY294002  (EXP)
maneb  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (EXP,ISO)
mercury atom  (ISO)
mercury(0)  (ISO)
methapyrilene  (EXP)
methyl salicylate  (ISO)
methylglyoxal  (ISO)
methylphenidate  (ISO)
methylseleninic acid  (ISO)
microcystin-LR  (ISO)
morphine  (EXP)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
N-nitrosodimethylamine  (EXP,ISO)
N-Nitrosopyrrolidine  (ISO)
NADP zwitterion  (ISO)
NADP(+)  (ISO)
naphthalenes  (ISO)
nickel dichloride  (ISO)
nickel sulfate  (ISO)
nitrates  (ISO)
non-2-enal  (ISO)
nonanal  (ISO)
O-methyleugenol  (ISO)
ochratoxin A  (ISO)
oct-2-enal  (ISO)
octanal  (ISO)
okadaic acid  (ISO)
oxaliplatin  (EXP)
ozone  (EXP)
paclitaxel  (ISO)
paracetamol  (ISO)
paraquat  (ISO)
parathion  (ISO)
pentanal  (ISO)
pentane-2,3-dione  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP)
phenethyl caffeate  (ISO)
phenobarbital  (ISO)
Phenylglyoxal  (ISO)
picoxystrobin  (ISO)
pirinixic acid  (ISO)
potassium dichromate  (ISO)
propan-2-ol  (ISO)
propanal  (ISO)
prostaglandin E2  (ISO)
pterostilbene  (ISO)
pyrimidifen  (ISO)
quercetin  (ISO)
rac-lactic acid  (ISO)
reactive oxygen species  (ISO)
resveratrol  (EXP,ISO)
rotenone  (ISO)
SB 203580  (EXP)
SB 431542  (ISO)
silicon dioxide  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (EXP,ISO)
sodium chloride  (ISO)
sodium dodecyl sulfate  (ISO)
sorbinil  (ISO)
streptozocin  (ISO)
sulindac  (ISO)
sulindac sulfone  (ISO)
sunitinib  (ISO)
tebufenpyrad  (ISO)
temozolomide  (ISO)
terbufos  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
topotecan  (EXP)
trans-isoeugenol  (ISO)
tributylstannane  (ISO)
Triptolide  (EXP)
triptonide  (ISO)
valproic acid  (ISO)
vitamin E  (ISO)
zearalenone  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

References

References - curated
# Reference Title Reference Citation
1. A systematic meta-analysis of genetic association studies for diabetic retinopathy. Abhary S, etal., Diabetes. 2009 Sep;58(9):2137-47. doi: 10.2337/db09-0059. Epub 2009 Jul 8.
2. Gel-based proteomics of liver cancer progression in rat. Albrethsen J, etal., Biochim Biophys Acta. 2011 Oct;1814(10):1367-76. Epub 2011 Jun 6.
3. Association analysis of nine candidate gene polymorphisms in Indian patients with type 2 diabetic retinopathy. Balasubbu S, etal., BMC Med Genet. 2010 Nov 10;11:158. doi: 10.1186/1471-2350-11-158.
4. Aldose reductase and p-crystallin belong to the same protein superfamily as aldehyde reductase. Carper D, etal., FEBS Lett 1987 Aug 10;220(1):209-13.
5. Aldose reductase inhibitor zopolrestat restores allergic hyporesponsiveness in alloxan-diabetic rats. Carvalho VF, etal., Eur J Pharmacol. 2006 Nov 7;549(1-3):173-8. Epub 2006 Aug 26.
6. Mechanical hyperalgesia in rat models of systemic and local hyperglycemia. Dobretsov M, etal., Brain Res. 2003 Jan 17;960(1-2):174-83.
7. Aldose reductase induced by hyperosmotic stress mediates cardiomyocyte apoptosis: differential effects of sorbitol and mannitol. Galvez AS, etal., J Biol Chem 2003 Oct 3;278(40):38484-94. Epub 2003 Jul 24.
8. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
9. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
10. Characterization of the aldose reductase-encoding gene family in rat. Graham C, etal., Gene 1991 Nov 15;107(2):259-67.
11. Polymorphism in the 5'-end of the aldose reductase gene is strongly associated with the development of diabetic nephropathy in type I diabetes. Heesom AE, etal., Diabetes. 1997 Feb;46(2):287-91.
12. Susceptibility to diabetic neuropathy in patients with insulin dependent diabetes mellitus is associated with a polymorphism at the 5' end of the aldose reductase gene. Heesom AE, etal., J Neurol Neurosurg Psychiatry. 1998 Feb;64(2):213-6.
13. Aldose reductase-deficient mice develop nephrogenic diabetes insipidus. Ho HT, etal., Mol Cell Biol. 2000 Aug;20(16):5840-6.
14. Aldose reductase pathway mediates JAK-STAT signaling: a novel axis in myocardial ischemic injury. Hwang YC, etal., FASEB J. 2005 May;19(7):795-7. Epub 2005 Mar 3.
15. The purification and properties of aldose reductase from rat ovary. Iwata N, etal., Arch Biochem Biophys. 1990 Oct;282(1):70-7.
16. Downregulation of renal TonEBP in hypokalemic rats. Jeon US, etal., Am J Physiol Renal Physiol. 2007 Apr 4;.
17. Aldose reductase regulates TGF-beta1-induced production of fibronectin and type IV collagen in cultured rat mesangial cells. Jiang T, etal., Nephrology (Carlton). 2006 Apr;11(2):105-12.
18. Topical aldose reductase inhibitor formulations for effective lens drug delivery in a rat model for sugar cataracts. Kador PF, etal., J Ocul Pharmacol Ther. 2007 Apr;23(2):116-23.
19. Redox activation of aldose reductase in the ischemic heart. Kaiserova K, etal., J Biol Chem. 2006 Jun 2;281(22):15110-20. Epub 2006 Mar 27.
20. Aldose reductase, a key enzyme in the oxidative deamination of norepinephrine in rats. Kawamura M, etal., Biochem Pharmacol. 1999 Aug 1;58(3):517-24.
21. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
22. Is sorbitol dehydrogenase gene expression affected by streptozotocin-diabetes in the rat? Kicic E and Palmer TN, Biochim Biophys Acta. 1994 May 25;1226(2):213-8.
23. Effects of melatonin on plasma oxidative stress in rats with streptozotocin induced diabetes. Klepac N, etal., Biomed Pharmacother. 2006 Jan;60(1):32-5. Epub 2005 Oct 25.
24. [Expression of genes involved in retinoic acid biosynthesis in human gastric cancer]. Kropotova ES, etal., Mol Biol (Mosk). 2013 Mar-Apr;47(2):317-30.
25. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
26. Acetic acid aldose reductase inhibitors bearing a five-membered heterocyclic core with potent topical activity in a visual impairment rat model. La Motta C, etal., J Med Chem. 2008 Jun 12;51(11):3182-93. doi: 10.1021/jm701613h. Epub 2008 May 2.
27. Enzymes in pancreatic islets that use NADP(H) as a cofactor including evidence for a plasma membrane aldehyde reductase. Laclau M, etal., Mol Cell Biochem. 2001 Sep;225(1-):151-60.
28. Evaluation of the prostaglandin F synthase activity of human and bovine aldo-keto reductases: AKR1A1s complement AKR1B1s as potent PGF synthases. Lacroix Pepin N, etal., Prostaglandins Other Lipid Mediat. 2013 Oct;106:124-32. doi: 10.1016/j.prostaglandins.2013.05.005. Epub 2013 Jun 6.
29. Regulation of AKR1B1 by thyroid hormone and its receptors. Liao CS, etal., Mol Cell Endocrinol. 2009 Aug 13;307(1-2):109-17. doi: 10.1016/j.mce.2009.04.013. Epub 2009 May 5.
30. Synthesis of flavonoids and their effects on aldose reductase and sorbitol accumulation in streptozotocin-induced diabetic rat tissues. Lim SS, etal., J Pharm Pharmacol. 2001 May;53(5):653-68.
31. Gene expression of enzymes comprising the polyol pathway in various rat tissues determined by the competitive RT-PCR method. Maekawa K, etal., Jpn J Pharmacol 2002 Jan;88(1):123-6.
32. Red blood cell sorbitol as an indicator of polyol pathway activity. Inhibition by sorbinil in insulin-dependent diabetic subjects. Malone JI, etal., Diabetes. 1984 Jan;33(1):45-9.
33. The unfolded protein response in lens epithelial cells from galactosemic rat lenses. Mulhern ML, etal., Invest Ophthalmol Vis Sci. 2006 Sep;47(9):3951-9.
34. Aldose reductase and myo-inositol transporter mRNA are independently regulated in rat renal medulla. Nakanishi T, etal., J Am Soc Nephrol. 1996 Feb;7(2):283-9.
35. Prevention of diabetes-induced albuminuria in transgenic rats overexpressing human aldose reductase. Ng DP, etal., Endocrine. 2002 Jun;18(1):47-56.
36. Characterization of aldose reductase and aldehyde reductase from the medulla of rat kidney. Ohta M, etal., Chem Pharm Bull (Tokyo). 1990 Jun;38(6):1639-43.
37. In vitro expression of rat lens aldose reductase in Escherichia coli. Old SE, etal., Proc Natl Acad Sci U S A. 1990 Jul;87(13):4942-5.
38. C(-106)T polymorphism of the aldose reductase gene and the progression rate of diabetic retinopathy. Olmos P, etal., Diabetes Res Clin Pract. 2006 Nov;74(2):175-82. Epub 2006 May 15.
39. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
40. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
41. Fine-structural localization of aldose reductase and ouabain-sensitive, K(+)-dependent p-nitro-phenylphosphatase in rat peripheral nerve. Powell HC, etal., Acta Neuropathol. 1991;81(5):529-39.
42. Effect of quercetin on galactose-induced hyperglycaemic oxidative stress in hepatic and neuronal tissues of Wistar rats. Ramana BV, etal., Acta Diabetol. 2006 Dec;43(4):135-41.
43. Endotoxin-induced cardiomyopathy and systemic inflammation in mice is prevented by aldose reductase inhibition. Ramana KV, etal., Circulation. 2006 Oct 24;114(17):1838-46. Epub 2006 Oct 9.
44. Aldose reductase mediates mitogenic signaling in vascular smooth muscle cells. Ramana KV, etal., J Biol Chem 2002 Aug 30;277(35):32063-70.
45. Mitogenic responses of vascular smooth muscle cells to lipid peroxidation-derived aldehyde 4-hydroxy-trans-2-nonenal (HNE): role of aldose reductase-catalyzed reduction of the HNE-glutathione conjugates in regulating cell growth. Ramana KV, etal., J Biol Chem. 2006 Jun 30;281(26):17652-60. Epub 2006 Apr 28.
46. Aldose reductase deficiency protects sugar-induced lens opacification in rats. Reddy AB, etal., Chem Biol Interact. 2011 May 30;191(1-3):346-50. doi: 10.1016/j.cbi.2011.02.028. Epub 2011 Mar 3.
47. GOA pipeline RGD automated data pipeline
48. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
49. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
50. Aldose reductase the major protein associated with naphthalene dihydrodiol dehydrogenase activity in rat lens. Sato S Invest Ophthalmol Vis Sci. 1993 Oct;34(11):3172-8.
51. Maturation of aldose reductase expression in the neonatal rat inner medulla. Schwartz GJ, etal., J Clin Invest. 1992 Oct;90(4):1275-83.
52. Aldose reductase gene expression is increased in diabetic nephropathy. Shah VO, etal., J Clin Endocrinol Metab 1997 Jul;82(7):2294-8.
53. Aldose reductase gene polymorphisms and susceptibility to microvascular complications in Type 2 diabetes. Sivenius K, etal., Diabet Med. 2004 Dec;21(12):1325-33.
54. Aldose reductase induction: a novel response to oxidative stress of smooth muscle cells. Spycher SE, etal., FASEB J. 1997 Feb;11(2):181-8.
55. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
56. A selective aldose reductase inhibitor of a new structural class prevents or reverses early retinal abnormalities in experimental diabetic retinopathy. Sun W, etal., Diabetes. 2006 Oct;55(10):2757-62.
57. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
58. Human aldose reductase expression accelerates diabetic atherosclerosis in transgenic mice. Vikramadithyan RK, etal., J Clin Invest. 2005 Sep;115(9):2434-43. Epub 2005 Aug 25.
59. Electron microscopic immunocytochemical evidence for the mechanism of blood-retinal barrier breakdown in galactosemic rats and its association with aldose reductase expression and inhibition. Vinores SA, etal., Exp Eye Res. 1993 Dec;57(6):723-35.
60. Additive effect of aldose reductase Z-4 microsatellite polymorphism and glycaemic control on cataract development in type 2 diabetes. Wang Y, etal., J Diabetes Complications. 2014 Mar-Apr;28(2):147-51. doi: 10.1016/j.jdiacomp.2013.10.011. Epub 2013 Oct 31.
61. Up-regulation of aldose reductase by the substrate, methylglyoxal. Yabe-Nishimura C, etal., Chem Biol Interact. 2003 Feb 1;143-144:317-23.
62. Aldose reductase inhibition prevents endotoxin-induced uveitis in rats. Yadav UC, etal., Invest Ophthalmol Vis Sci. 2007 Oct;48(10):4634-42.
63. Inhibitory effects of astragaloside IV on diabetic peripheral neuropathy in rats. Yu J, etal., Can J Physiol Pharmacol. 2006 Jun;84(6):579-87.
64. Aldose reductase-mediated induction of epithelium-to-mesenchymal transition (EMT) in lens. Zablocki GJ, etal., Chem Biol Interact. 2011 May 30;191(1-3):351-6. doi: 10.1016/j.cbi.2011.02.005. Epub 2011 Feb 15.
65. Proteomic changes of PC12 cells treated with proteasomal inhibitor PSI. Zhang L, etal., Brain Res. 2007 Jun 11;1153:196-203. Epub 2007 Mar 30.
Additional References at PubMed
PMID:1420136   PMID:7498172   PMID:7851421   PMID:8435445   PMID:11772943   PMID:12732097   PMID:15272156   PMID:15489334   PMID:16449351   PMID:16567509   PMID:17978503   PMID:19056867  
PMID:20308528   PMID:20417192   PMID:20458337   PMID:20837989   PMID:21136599   PMID:21656371   PMID:22082260   PMID:22658411   PMID:22844269   PMID:23106098   PMID:23376485   PMID:23533145  
PMID:24180671   PMID:26056446   PMID:26291727   PMID:26316108   PMID:28386557   PMID:29948725   PMID:31604989   PMID:34800366   PMID:38188141  


Genomics

Comparative Map Data
Akr1b1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8463,899,222 - 63,913,315 (-)NCBIGRCr8
GRCr8 Ensembl463,899,222 - 63,913,315 (-)EnsemblGRCr8 Ensembl
mRatBN7.2462,932,033 - 62,946,126 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl462,932,031 - 62,946,157 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx467,882,584 - 67,896,684 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0463,798,307 - 63,812,409 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0462,200,710 - 62,214,808 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0461,706,866 - 61,720,959 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl461,706,864 - 61,720,956 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0461,426,190 - 61,440,279 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4461,645,438 - 61,659,530 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera457,984,561 - 57,998,653 (-)NCBICelera
RGSC_v3.1461,921,567 - 61,935,660 (-)NCBI
RH 3.4 Map4393.32RGD
Cytogenetic Map4q22NCBI
AKR1B1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh387134,442,350 - 134,459,239 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl7134,442,356 - 134,459,284 (-)EnsemblGRCh38hg38GRCh38
GRCh377134,127,102 - 134,143,991 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 367133,777,647 - 133,794,428 (-)NCBINCBI36Build 36hg18NCBI36
Build 347133,584,361 - 133,601,143NCBI
Celera7128,864,507 - 128,881,287 (-)NCBICelera
Cytogenetic Map7q33NCBI
HuRef7128,428,754 - 128,445,534 (-)NCBIHuRef
CHM1_17134,061,391 - 134,078,169 (-)NCBICHM1_1
T2T-CHM13v2.07135,750,388 - 135,767,276 (-)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v27133,471,421 - 133,488,201 (-)NCBI
Akr1b1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39634,280,865 - 34,294,424 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl634,279,369 - 34,294,413 (-)EnsemblGRCm39 Ensembl
GRCm38634,303,930 - 34,317,489 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl634,302,434 - 34,317,478 (-)EnsemblGRCm38mm10GRCm38
MGSCv37634,253,930 - 34,267,489 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36634,234,092 - 34,247,629 (-)NCBIMGSCv36mm8
Celera634,300,847 - 34,314,402 (-)NCBICelera
Cytogenetic Map6B1NCBI
cM Map614.87NCBI
AKR1B1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v26171,258,419 - 171,275,280 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1723,268,674 - 23,285,469 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v07126,400,861 - 126,417,756 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.17138,907,448 - 138,924,317 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl7138,912,953 - 138,924,095 (-)Ensemblpanpan1.1panPan2
AKR1B1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1142,991,888 - 3,006,941 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl142,991,888 - 3,006,940 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha142,649,050 - 2,664,066 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0142,721,426 - 2,736,482 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl142,721,426 - 2,736,481 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1142,926,088 - 2,941,099 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0142,670,903 - 2,685,919 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0142,816,445 - 2,831,531 (+)NCBIUU_Cfam_GSD_1.0
Akr1b1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440511821,179,563 - 21,195,800 (+)NCBIHiC_Itri_2
SpeTri2.0NW_0049365791,312,175 - 1,328,397 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
AKR1B1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1814,684,036 - 14,752,310 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11814,593,516 - 14,752,316 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21815,596,806 - 15,614,673 (+)NCBISscrofa10.2Sscrofa10.2susScr3
LOC103226928
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.121103,060,018 - 103,076,844 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl21103,059,991 - 103,077,341 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666042271,394 - 288,078 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in Akr1b1
22 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:35
Count of miRNA genes:32
Interacting mature miRNAs:33
Transcripts:ENSRNOT00000012879
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
5685012Bmd87Bone mineral density QTL 875.1tibia mineral mass (VT:1000283)bone mineral content (CMO:0001554)43511329080113290Rat
1358352Srcrt3Stress Responsive Cort QTL 32.29blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)439431983123203361Rat
1549843Bw53Body weight QTL 530.0001body mass (VT:0001259)body weight gain (CMO:0000420)459753119104753119Rat
61445Strs3Sensitivity to stroke QTL 33cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)44140057786400577Rat
6893678Bw108Body weight QTL 1082.60.006body mass (VT:0001259)body weight (CMO:0000012)44442502489425024Rat
5685009Bmd86Bone mineral density QTL 863.7tibia mineral mass (VT:1000283)bone mineral density (CMO:0001226)457613242102613242Rat
10755501Bp390Blood pressure QTL 3902.5arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)427730518170099664Rat
1331807Rf31Renal function QTL 312.988urine potassium amount (VT:0010539)urine potassium level (CMO:0000128)44049044275726188Rat
634311Sach7Saccharin preference QTL 7taste sensitivity trait (VT:0001986)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)45807987582597589Rat
1358363Sradr3Stress Responsive Adrenal Weight QTL 36.19adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)458817672103817672Rat
61330Eau1Experimental allergic uveoretinitis QTL 10.0003uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)426234499134199155Rat
738009Sach4Saccharine consumption QTL 44.90.000016consumption behavior trait (VT:0002069)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)460916264184426481Rat
631261Tcas3Tongue tumor susceptibility QTL 36.88tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)41170660492690519Rat
61336Bp21Blood pressure QTL 214.6arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)45808014680212111Rat
2313401Anxrr27Anxiety related response QTL 27aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)41890069763900697Rat
2312569Pur19Proteinuria QTL 193.40.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)459836842104836842Rat
8655961Kidm43Kidney mass QTL 4318kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)43726957782269577Rat
1354612Foco1Food consumption QTL 18.87eating behavior trait (VT:0001431)food intake rate (CMO:0000427)445429897149763204Rat
6909128Pancm4Pancreatic morphology QTL 411.35pancreas mass (VT:0010144)pancreas wet weight (CMO:0000626)427862204126119996Rat
634344Hcar7Hepatocarcinoma resistance QTL 77.8liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)46104105794638356Rat
2303168Bp330Blood pressure QTL 3304.250.017arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)45889999148002343Rat
61475Aia2Adjuvant induced arthritis QTL 25.8joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)44047145375939996Rat
8694439Bw168Body weight QTL 1689.570.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)44140060386400603Rat
738031Alc14Alcohol consumption QTL 147.60.00003consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)460916264174095838Rat
8552807Vie4Viral induced encephalitis QTL 47.3brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)41890069763900697Rat
8655906Rf60Renal function QTL 603.8blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)43044896182336920Rat
1576305Emca6Estrogen-induced mammary cancer QTL 65.8mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)445429709157555683Rat
61418Pia5Pristane induced arthritis QTL 54.5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)463245026129846354Rat
7387227Uae40Urinary albumin excretion QTL 402.90.0052urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)41891315163913151Rat
738016Alc16Alcohol consumption QTL 163.60.00015consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)460916264184426481Rat
1558651Swd3Spike wave discharge measurement QTL 34.620.000024brain electrophysiology trait (VT:0010557)brain spike-and-wave discharge frequency (CMO:0001742)44140057786400577Rat
1358203Stl19Serum triglyceride level QTL 192.80.002blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)42192515166925151Rat
1354660Salc1Saline consumption QTL 111.26drinking behavior trait (VT:0001422)saline drink intake rate (CMO:0001627)445429897149763204Rat
1641833Alc21Alcohol consumption QTL 218.60.0001drinking behavior trait (VT:0001422)ethanol drink intake rate (CMO:0001407)457664252127749483Rat
70192BpQTLcluster5Blood pressure QTL cluster 54.183arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)4163900697Rat
1298082Stresp4Stress response QTL 4blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)451085655113588029Rat
631546Bp86Blood pressure QTL 863.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)45807987592690793Rat
1300139Hrtrt6Heart rate QTL 62.85heart pumping trait (VT:2000009)heart rate (CMO:0000002)440490442117737312Rat
70200Alc18Alcohol consumption QTL 189.2drinking behavior trait (VT:0001422)ethanol intake volume to total fluid intake volume ratio (CMO:0001591)457613339151163960Rat
61434Cia3Collagen induced arthritis QTL 34.8joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)463224393108224393Rat
7394826Bw126Body weight QTL 1260.002body mass (VT:0001259)body weight gain (CMO:0000420)46390045888813920Rat
12798520Anxrr55Anxiety related response QTL 554.450.01locomotor behavior trait (VT:0001392)number of rearing movements with lid-pushing in an experimental apparatus (CMO:0002715)433538597116185060Rat
4889969Bss96Bone structure and strength QTL 964.9tibia size trait (VT:0100001)tibia cortical bone volume (CMO:0001725)457613242102613242Rat
2316958Gluco58Glucose level QTL 5810blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)412212457182430611Rat
4889972Bss97Bone structure and strength QTL 975.6tibia size trait (VT:0100001)tibia total bone volume (CMO:0001724)457613242102613242Rat
631671Iddm11Insulin dependent diabetes mellitus QTL 113.60.0012blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)45960331980216952Rat


Related Rat Strains
The following Strains have been annotated to Akr1b1
NP.P-(D4Rat119-D4Rat55)/Iusm    


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
9 11 49 113 91 90 59 25 59 6 218 97 11 93 45 60 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000012879   ⟹   ENSRNOP00000012879
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl463,899,222 - 63,913,315 (-)Ensembl
mRatBN7.2 Ensembl462,932,035 - 62,946,126 (-)Ensembl
Rnor_6.0 Ensembl461,706,864 - 61,720,956 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000101474   ⟹   ENSRNOP00000082377
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl463,899,222 - 63,913,315 (-)Ensembl
mRatBN7.2 Ensembl462,932,031 - 62,946,126 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000109902   ⟹   ENSRNOP00000089852
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl463,901,414 - 63,913,315 (-)Ensembl
mRatBN7.2 Ensembl462,934,225 - 62,946,157 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000113859   ⟹   ENSRNOP00000085990
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl462,936,543 - 62,946,157 (-)Ensembl
RefSeq Acc Id: NM_012498   ⟹   NP_036630
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8463,899,222 - 63,913,315 (-)NCBI
mRatBN7.2462,932,033 - 62,946,126 (-)NCBI
Rnor_6.0461,706,866 - 61,720,959 (-)NCBI
Rnor_5.0461,426,190 - 61,440,279 (-)NCBI
RGSC_v3.4461,645,438 - 61,659,530 (-)RGD
Celera457,984,561 - 57,998,653 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_036630 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA40721 (Get FASTA)   NCBI Sequence Viewer  
  AAH62034 (Get FASTA)   NCBI Sequence Viewer  
  CAA29308 (Get FASTA)   NCBI Sequence Viewer  
  EDM15300 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000012879
GenBank Protein P07943 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_036630   ⟸   NM_012498
- UniProtKB: P07943 (UniProtKB/Swiss-Prot),   A6IEL2 (UniProtKB/TrEMBL),   A0A8L2UIN9 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000012879   ⟸   ENSRNOT00000012879
Ensembl Acc Id: ENSRNOP00000085990   ⟸   ENSRNOT00000113859
Ensembl Acc Id: ENSRNOP00000089852   ⟸   ENSRNOT00000109902
Ensembl Acc Id: ENSRNOP00000082377   ⟸   ENSRNOT00000101474
Protein Domains
NADP-dependent oxidoreductase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P07943-F1-model_v2 AlphaFold P07943 1-316 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13692951
Promoter ID:EPDNEW_R3476
Type:multiple initiation site
Name:Akr1b1_1
Description:aldo-keto reductase family 1 member B
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0461,720,959 - 61,721,019EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2092 AgrOrtholog
BioCyc Gene G2FUF-45279 BioCyc
Ensembl Genes ENSRNOG00000009513 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000012879 ENTREZGENE
Gene3D-CATH 3.20.20.100 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:5623700 IMAGE-MGC_LOAD
InterPro Aldo/ket_reductase_CS UniProtKB/Swiss-Prot
  Aldo/keto_reductase UniProtKB/Swiss-Prot
  NADP_OxRdtase_dom UniProtKB/Swiss-Prot
  NADP_OxRdtase_dom_sf UniProtKB/Swiss-Prot
KEGG Report rno:24192 UniProtKB/Swiss-Prot
MGC_CLONE MGC:72549 IMAGE-MGC_LOAD
NCBI Gene 24192 ENTREZGENE
PANTHER ALDO/KETO REDUCTASE UniProtKB/Swiss-Prot
Pfam Aldo_ket_red UniProtKB/Swiss-Prot
PhenoGen Akr1b1 PhenoGen
PIRSF AKR UniProtKB/Swiss-Prot
PRINTS ALDKETRDTASE UniProtKB/Swiss-Prot
PROSITE ALDOKETO_REDUCTASE_1 UniProtKB/Swiss-Prot
  ALDOKETO_REDUCTASE_2 UniProtKB/Swiss-Prot
  ALDOKETO_REDUCTASE_3 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000009513 RatGTEx
Superfamily-SCOP SSF51430 UniProtKB/Swiss-Prot
TIGR TC204034
UniProt A0A8I5ZTF9_RAT UniProtKB/TrEMBL
  A0A8I6A2P8_RAT UniProtKB/TrEMBL
  A0A8I6A856_RAT UniProtKB/TrEMBL
  A0A8L2UIN9 ENTREZGENE, UniProtKB/TrEMBL
  A6IEL2 ENTREZGENE, UniProtKB/TrEMBL
  ALDR_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-04-08 Akr1b1  aldo-keto reductase family 1 member B1  Akr1b1  aldo-keto reductase family 1 member B  Name changed 629549 APPROVED
2016-06-08 Akr1b1  aldo-keto reductase family 1 member B  Akr1b1  aldo-keto reductase family 1, member B1 (aldose reductase)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-15 Akr1b1  aldo-keto reductase family 1, member B1 (aldose reductase)  Akr1b4  aldo-keto reductase family 1, member B4 (aldose reductase)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-05-03 Akr1b4  aldo-keto reductase family 1, member B4 (aldose reductase)  Aldr1  Aldehyde reductase 1 (low Km aldose reductase) (5.8 kb PstI fragment, probably the functional gene)  Symbol and Name updated to reflect official family nomenclature 1299863 APPROVED
2002-06-10 Aldr1  Aldehyde reductase 1 (low Km aldose reductase) (5.8 kb PstI fragment, probably the functional gene)      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_disease may be involved in the pathogenesis of diabetic complications 632191
gene_expression enzyme detected in lens 632191
gene_process may play a role in the polyol pathway 632193
gene_process regulates NF-kappa B mediated mitogenic signaling 632192
gene_product may be a member of protein superfamily that includes aldose reductase, p-crystallin, and aldehyde reductase 632191