(+)-alpha-tocopherol increases expression EXP 6480464 alpha-Tocopherol results in increased expression of AKR1B1 mRNA CTD PMID:16908007 (2E)-hexenal affects reduction ISO RGD:732178 6480464 AKR1B1 protein affects the reduction of 2-hexenal CTD PMID:11306073 (2E)-hexenal increases reduction ISO RGD:732178 6480464 AKR1B1 protein results in increased reduction of 2-hexenal, AKR1B1 protein results in increased reduction of 2-hexenal metabolite CTD PMID:21329684 , PMID:9890881 (4-oxo-3-\{[5-(trifluoromethyl)-1,3-benzothiazol-2-yl]methyl\}-3,4-dihydrophthalazin-1-yl)acetic acid decreases activity ISO RGD:732178 6480464 zopolrestat results in decreased activity of AKR1B1 protein CTD PMID:21334316 (4-oxo-3-\{[5-(trifluoromethyl)-1,3-benzothiazol-2-yl]methyl\}-3,4-dihydrophthalazin-1-yl)acetic acid multiple interactions ISO RGD:732178 6480464 [zopolrestat results in decreased activity of AKR1B1 protein] inhibits the reaction [Antigens, Plant results in increased abundance of Reactive Oxygen Species] more ... CTD PMID:21334316 (E)-cinnamyl alcohol increases expression ISO RGD:732178 6480464 cinnamyl alcohol results in increased expression of AKR1B1 mRNA CTD PMID:20566472 (E,E)-2,4-hexadienal increases reduction ISO RGD:732178 6480464 AKR1B1 protein results in increased reduction of 2 more ... CTD PMID:21329684 , PMID:9890881 (R)-acetoin increases reduction ISO RGD:732178 6480464 AKR1B1 protein results in increased reduction of Acetoin CTD PMID:23295224 (R)-acetoin multiple interactions ISO RGD:732178 6480464 [AKR1B1 protein results in increased reduction of Acetoin] which results in increased chemical synthesis of 2 more ... CTD PMID:23295224 (S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE multiple interactions EXP 6480464 [oxaliplatin co-treated with Topotecan] results in increased expression of AKR1B1 mRNA CTD PMID:25729387 1,2-Naphthoquinone increases reduction ISO RGD:732178 6480464 AKR1B1 protein results in increased reduction of 1, 2-naphthoquinone CTD PMID:10510318 1-chloro-2,4-dinitrobenzene increases expression ISO RGD:732178 6480464 Dinitrochlorobenzene results in increased expression of AKR1B1 mRNA CTD PMID:20566472 1-naphthyl isothiocyanate increases expression EXP 6480464 1-Naphthylisothiocyanate results in increased expression of AKR1B1 mRNA CTD PMID:25380136 16-Ketoestrone increases reduction ISO RGD:732178 6480464 AKR1B1 protein results in increased reduction of 16-ketoestrone CTD PMID:10510318 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO RGD:732178 6480464 Tetrachlorodibenzodioxin affects the expression of AKR1B1 mRNA CTD PMID:20106945 , PMID:22298810 2,3,7,8-tetrachlorodibenzodioxine decreases expression ISO RGD:732178 6480464 Tetrachlorodibenzodioxin results in decreased expression of AKR1B1 mRNA CTD PMID:19684285 , PMID:21632981 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO RGD:736610 6480464 Tetrachlorodibenzodioxin affects the expression of AKR1B3 mRNA CTD PMID:21570461 2,3,7,8-tetrachlorodibenzodioxine affects expression EXP 6480464 Tetrachlorodibenzodioxin affects the expression of AKR1B1 mRNA CTD PMID:22298810 2,3-dimethoxynaphthalene-1,4-dione decreases expression ISO RGD:732178 6480464 2 more ... CTD PMID:17547211 2,4-Nonadienal increases reduction ISO RGD:732178 6480464 AKR1B1 protein results in increased reduction of 2, 4-nonadienal CTD PMID:9890881 2-acetamidofluorene increases expression ISO RGD:736610 6480464 2-Acetylaminofluorene results in increased expression of AKR1B3 mRNA CTD PMID:17317680 2-hexenal increases reduction ISO RGD:732178 6480464 AKR1B1 protein results in increased reduction of 2-hexenal, AKR1B1 protein results in increased reduction of 2-hexenal metabolite CTD PMID:21329684 , PMID:9890881 2-hexenal affects reduction ISO RGD:732178 6480464 AKR1B1 protein affects the reduction of 2-hexenal CTD PMID:11306073 2-hydroxypropanoic acid increases expression ISO RGD:732178 6480464 Lactic Acid results in increased expression of AKR1B1 mRNA CTD PMID:20566472 2-pentenal increases reduction ISO RGD:732178 6480464 AKR1B1 protein results in increased reduction of 2-pentenal CTD PMID:9890881 2-pentenal affects reduction ISO RGD:732178 6480464 AKR1B1 protein affects the reduction of 2-pentenal CTD PMID:11306073 3,4-dihydroxybenzoic acid multiple interactions ISO RGD:736610 6480464 protocatechuic acid inhibits the reaction [Galactose results in increased expression of AKR1B3 mRNA] CTD PMID:22687555 3-chloropropane-1,2-diol decreases expression EXP 6480464 alpha-Chlorohydrin results in decreased expression of AKR1B1 mRNA CTD PMID:28522335 3-isobutyl-1-methyl-7H-xanthine multiple interactions ISO RGD:736610 6480464 [1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein] results in increased expression of AKR1B3 mRNA CTD PMID:24848799 3-isobutyl-1-methyl-7H-xanthine multiple interactions ISO RGD:732178 6480464 [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of AKR1B1 mRNA CTD PMID:28628672 4,4'-diaminodiphenylmethane increases expression EXP 6480464 4, 4'-diaminodiphenylmethane results in increased expression of AKR1B1 mRNA CTD PMID:25380136 4,4'-diaminodiphenylmethane increases expression ISO RGD:736610 6480464 4, 4'-diaminodiphenylmethane results in increased expression of AKR1B3 mRNA CTD PMID:18648102 4,4'-sulfonyldiphenol multiple interactions ISO RGD:732178 6480464 [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of AKR1B1 mRNA CTD PMID:28628672 4-hydroxynon-2-enal affects reduction ISO RGD:732178 6480464 AKR1B1 protein affects the reduction of 4-hydroxy-2-nonenal CTD PMID:11306073 4-hydroxynon-2-enal increases reduction ISO RGD:732178 6480464 AKR1B1 protein results in increased reduction of 4-hydroxy-2-nonenal, AKR1B1 protein results in increased reduction of 4-hydroxy-2-nonenal metabolite CTD PMID:10510318 more ... 4-hydroxyphenyl retinamide decreases expression ISO RGD:736610 6480464 Fenretinide results in decreased expression of AKR1B1 mRNA CTD PMID:28973697 4-nitrobenzaldehyde increases reduction ISO RGD:732178 6480464 AKR1B1 protein results in increased reduction of 4-nitrobenzaldehyde CTD PMID:10510318 9,10-phenanthroquinone increases reduction ISO RGD:732178 6480464 AKR1B1 protein results in increased reduction of 9, 10-phenanthrenequinone CTD PMID:10510318 9,10-phenanthroquinone multiple interactions ISO RGD:732178 6480464 AKR1B1 protein results in increased reduction of and affects the activity of 9, 10-phenanthrenequinone CTD PMID:21910479 acetoin increases reduction ISO RGD:732178 6480464 AKR1B1 protein results in increased reduction of Acetoin CTD PMID:23295224 acetoin multiple interactions ISO RGD:732178 6480464 [AKR1B1 protein results in increased reduction of Acetoin] which results in increased chemical synthesis of 2 more ... CTD PMID:23295224 acrolein affects reduction ISO RGD:732178 6480464 AKR1B1 protein affects the reduction of Acrolein CTD PMID:11306073 acrolein increases expression ISO RGD:736610 6480464 Acrolein results in increased expression of AKR1B3 protein CTD PMID:28482051 acrolein increases reduction ISO RGD:732178 6480464 AKR1B1 protein results in increased reduction of Acrolein, AKR1B1 protein results in increased reduction of Acrolein metabolite CTD PMID:10510318 more ... aflatoxin B1 affects expression ISO RGD:732178 6480464 Aflatoxin B1 affects the expression of AKR1B1 protein CTD PMID:20106945 aflatoxin B1 increases expression ISO RGD:732178 6480464 Aflatoxin B1 results in increased expression of AKR1B1 mRNA CTD PMID:22100608 , PMID:27153756 aldehydo-D-glucose increases expression ISO RGD:736610 6480464 Glucose results in increased expression of AKR1B3 mRNA, Glucose results in increased expression of AKR1B3 protein CTD PMID:16805838 aldehydo-D-glucose multiple interactions ISO RGD:732178 6480464 AKR1B1 protein promotes the reaction [Glucose results in increased abundance of Sorbitol] CTD PMID:25451566 all-trans-4-oxoretinal increases reduction ISO RGD:732178 6480464 AKR1B1 protein results in increased reduction of 4-oxoretinaldehyde CTD PMID:19014918 all-trans-dehydroretinal increases reduction ISO RGD:732178 6480464 AKR1B1 protein results in increased reduction of dehydroretinal CTD PMID:19014918 all-trans-retinal increases reduction ISO RGD:732178 6480464 AKR1B1 protein results in increased reduction of Retinaldehyde CTD PMID:19014918 all-trans-retinol decreases response to substance ISO RGD:732178 6480464 AKR1B1 protein results in decreased susceptibility to Vitamin A, AKR1B1 protein results in decreased susceptibility to Vitamin A metabolite CTD PMID:19014918 alpha-D-galactose multiple interactions ISO RGD:736610 6480464 protocatechuic acid inhibits the reaction [Galactose results in increased expression of AKR1B3 mRNA] CTD PMID:22687555 alpha-D-galactose increases expression ISO RGD:736610 6480464 Galactose results in increased expression of AKR1B3 mRNA CTD PMID:22687555 alpha-hexylcinnamaldehyde increases expression ISO RGD:732178 6480464 hexyl cinnamic aldehyde results in increased expression of AKR1B1 mRNA CTD PMID:20566472 ammonium chloride affects expression EXP 6480464 Ammonium Chloride affects the expression of AKR1B1 mRNA CTD PMID:16483693 anthra[1,9-cd]pyrazol-6(2H)-one multiple interactions EXP 6480464 pyrazolanthrone inhibits the reaction [Curcumin results in increased expression of AKR1B1 mRNA] CTD PMID:17640564 antimony(0) decreases expression ISO RGD:732178 6480464 Antimony results in decreased expression of AKR1B1 mRNA CTD PMID:17547211 antimony(3+) decreases expression ISO RGD:732178 6480464 Antimony results in decreased expression of AKR1B1 mRNA CTD PMID:17547211 Bandrowski's base increases expression ISO RGD:732178 6480464 Bandrowski's base results in increased expression of AKR1B1 mRNA CTD PMID:20566472 benzo[a]pyrene increases expression ISO RGD:736610 6480464 Benzo(a)pyrene results in increased expression of AKR1B3 mRNA CTD PMID:20127859 , PMID:22228805 benzo[a]pyrene increases expression ISO RGD:732178 6480464 Benzo(a)pyrene results in increased expression of AKR1B1 mRNA CTD PMID:20106945 more ... benzo[a]pyrene increases expression EXP 6480464 Benzo(a)pyrene results in increased expression of AKR1B1 protein CTD PMID:16456883 benzo[a]pyrene multiple interactions EXP 6480464 [Benzo(a)pyrene co-treated with 1 more ... CTD PMID:16456883 , PMID:18711122 benzo[a]pyrene multiple interactions ISO RGD:732178 6480464 [Benzo(a)pyrene co-treated with 1 more ... CTD PMID:17690111 Benzo[a]pyrene-7,8-diol multiple interactions ISO RGD:732178 6480464 [AKR1B1 protein co-treated with NADP] results in increased oxidation of and affects the activity of benzo(a)pyrene 7, 8-dihydrodiol CTD PMID:21910479 benzo[a]pyrene-7,8-dione multiple interactions ISO RGD:732178 6480464 [AKR1B1 protein co-treated with NADP] results in increased reduction of and affects the activity of benzo(a)pyrene-7, 8-dione CTD PMID:21910479 benzo[b]fluoranthene multiple interactions ISO RGD:732178 6480464 [Benzo(a)pyrene co-treated with benzo(b)fluoranthene] affects the expression of AKR1B1 mRNA CTD PMID:17690111 Benzo[k]fluoranthene increases expression ISO RGD:736610 6480464 benzo(k)fluoranthene results in increased expression of AKR1B3 mRNA CTD PMID:26377693 benzoic acid increases expression ISO RGD:732178 6480464 Benzoic Acid results in increased expression of AKR1B1 mRNA CTD PMID:20566472 benzyl alcohol increases oxidation ISO RGD:732178 6480464 AKR1B1 protein results in increased oxidation of Benzyl Alcohol CTD PMID:17194029 bisphenol A multiple interactions EXP 6480464 [Fructose co-treated with bisphenol A] results in increased expression of AKR1B1 protein CTD PMID:26930160 bisphenol A increases methylation EXP 6480464 bisphenol A results in increased methylation of AKR1B1 gene CTD PMID:28505145 bisphenol A decreases expression EXP 6480464 bisphenol A results in decreased expression of AKR1B1 protein CTD PMID:20219716 bisphenol A increases expression EXP 6480464 bisphenol A results in increased expression of AKR1B1 mRNA CTD PMID:25181051 bortezomib increases expression ISO RGD:732178 6480464 Bortezomib results in increased expression of AKR1B1 mRNA, Bortezomib results in increased expression of AKR1B1 protein CTD PMID:21215737 butanal affects reduction ISO RGD:732178 6480464 AKR1B1 protein affects the reduction of butyraldehyde CTD PMID:11306073 butanal increases reduction ISO RGD:732178 6480464 AKR1B1 protein results in increased reduction of butyraldehyde CTD PMID:9890881 butane-2,3-diol multiple interactions ISO RGD:732178 6480464 [AKR1B1 protein results in increased reduction of Acetoin] which results in increased chemical synthesis of 2, 3-butylene glycol CTD PMID:23295224 butane-2,3-dione increases reduction ISO RGD:732178 6480464 AKR1B1 protein results in increased reduction of Diacetyl CTD PMID:23295224 butane-2,3-dione multiple interactions ISO RGD:732178 6480464 [AKR1B1 protein results in increased reduction of Diacetyl] which results in increased chemical synthesis of Acetoin CTD PMID:23295224 cadmium atom decreases expression ISO RGD:732178 6480464 Cadmium results in decreased expression of AKR1B1 mRNA CTD PMID:17547211 cadmium dichloride decreases expression ISO RGD:732178 6480464 Cadmium Chloride results in decreased expression of AKR1B1 mRNA CTD PMID:17547211 cadmium dichloride increases expression ISO RGD:732178 6480464 Cadmium Chloride results in increased expression of AKR1B1 protein CTD PMID:24527689 candesartan decreases expression EXP 6480464 candesartan results in decreased expression of AKR1B1 mRNA CTD PMID:14871019 capecitabine decreases response to substance ISO RGD:732178 6480464 AKR1B1 protein results in decreased susceptibility to Capecitabine CTD PMID:16734730 carbon nanotube affects expression ISO RGD:732178 6480464 Nanotubes, Carbon affects the expression of AKR1B1 protein CTD PMID:22001959 carbon nanotube increases expression ISO RGD:736610 6480464 Nanotubes, Carbon analog results in increased expression of AKR1B3 mRNA CTD PMID:25554681 carboplatin increases expression EXP 6480464 Carboplatin results in increased expression of AKR1B1 mRNA CTD PMID:18172885 carmustine affects response to substance ISO RGD:732178 6480464 AKR1B1 mRNA affects the susceptibility to Carmustine CTD PMID:16365179 cefaloridine increases expression EXP 6480464 Cephaloridine results in increased expression of AKR1B1 mRNA CTD PMID:18172885 ceruletide increases expression EXP 6480464 Ceruletide results in increased expression of AKR1B1 protein CTD PMID:18024178 choline multiple interactions ISO RGD:736610 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of AKR1B3 mRNA CTD PMID:20938992 chromium atom decreases expression ISO RGD:732178 6480464 Chromium results in decreased expression of AKR1B1 mRNA CTD PMID:17547211 chromium(3+) decreases expression ISO RGD:732178 6480464 Chromium results in decreased expression of AKR1B1 mRNA CTD PMID:17547211 chromium(6+) affects expression ISO RGD:736610 6480464 chromium hexavalent ion affects the expression of AKR1B3 mRNA CTD PMID:28472532 cinnamyl alcohol increases expression ISO RGD:732178 6480464 cinnamyl alcohol results in increased expression of AKR1B1 mRNA CTD PMID:20566472 cisplatin decreases expression ISO RGD:732178 6480464 Cisplatin results in decreased expression of AKR1B1 protein CTD PMID:16803524 cisplatin increases phosphorylation ISO RGD:736610 6480464 Cisplatin results in increased phosphorylation of AKR1B3 protein CTD PMID:22006019 cisplatin increases expression EXP 6480464 Cisplatin results in increased expression of AKR1B1 mRNA CTD PMID:18172885 clobetasol increases expression ISO RGD:736610 6480464 Clobetasol results in increased expression of AKR1B3 mRNA CTD PMID:27462272 Clofop increases reduction ISO RGD:732178 6480464 AKR1B1 protein results in increased reduction of fenofibric acid CTD PMID:27599626 copper atom multiple interactions ISO RGD:732178 6480464 [NSC 689534 binds to Copper] which results in increased expression of AKR1B1 mRNA CTD PMID:20971185 copper atom decreases expression EXP 6480464 Copper deficiency results in decreased expression of AKR1B1 protein, Copper results in decreased expression of AKR1B1 mRNA CTD PMID:18993053 , PMID:30556269 copper atom increases expression EXP 6480464 Copper results in increased expression of AKR1B1 mRNA CTD PMID:22465980 copper(0) multiple interactions ISO RGD:732178 6480464 [NSC 689534 binds to Copper] which results in increased expression of AKR1B1 mRNA CTD PMID:20971185 copper(0) decreases expression EXP 6480464 Copper deficiency results in decreased expression of AKR1B1 protein, Copper results in decreased expression of AKR1B1 mRNA CTD PMID:18993053 , PMID:30556269 copper(0) increases expression EXP 6480464 Copper results in increased expression of AKR1B1 mRNA CTD PMID:22465980 copper(2+) increases expression EXP 6480464 Copper results in increased expression of AKR1B1 mRNA CTD PMID:22465980 copper(2+) decreases expression EXP 6480464 Copper deficiency results in decreased expression of AKR1B1 protein, Copper results in decreased expression of AKR1B1 mRNA CTD PMID:18993053 , PMID:30556269 copper(2+) multiple interactions ISO RGD:732178 6480464 [NSC 689534 binds to Copper] which results in increased expression of AKR1B1 mRNA CTD PMID:20971185 crocidolite asbestos increases expression ISO RGD:732178 6480464 Asbestos, Crocidolite results in increased expression of AKR1B1 mRNA CTD PMID:29523930 crotonaldehyde increases reduction ISO RGD:732178 6480464 AKR1B1 protein results in increased reduction of 2-butenal, AKR1B1 protein results in increased reduction of 2-butenal metabolite CTD PMID:21329684 , PMID:9890881 curcumin increases expression ISO RGD:736610 6480464 Curcumin results in increased expression of AKR1B1 mRNA CTD PMID:18200517 curcumin multiple interactions EXP 6480464 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Curcumin results in increased expression of AKR1B1 mRNA] more ... CTD PMID:17640564 , PMID:18588981 curcumin increases expression EXP 6480464 Curcumin results in increased expression of AKR1B1 mRNA, Curcumin results in increased expression of AKR1B1 protein CTD PMID:17640564 more ... curcumin increases activity EXP 6480464 Curcumin results in increased activity of AKR1B1 protein CTD PMID:17640564 cyclosporin A increases expression ISO RGD:732178 6480464 Cyclosporine results in increased expression of AKR1B1 mRNA CTD PMID:20106945 cyclosporin A decreases expression ISO RGD:732178 6480464 Cyclosporine results in decreased expression of AKR1B1 mRNA CTD PMID:25562108 , PMID:27989131 D-glucitol multiple interactions ISO RGD:732178 6480464 AKR1B1 protein promotes the reaction [Glucose results in increased abundance of Sorbitol] CTD PMID:25451566 D-glucitol increases abundance ISO RGD:732178 6480464 AKR1B1 protein results in increased abundance of Sorbitol CTD PMID:25541468 D-glucose increases expression ISO RGD:736610 6480464 Glucose results in increased expression of AKR1B3 mRNA, Glucose results in increased expression of AKR1B3 protein CTD PMID:16805838 D-glucose multiple interactions ISO RGD:732178 6480464 AKR1B1 protein promotes the reaction [Glucose results in increased abundance of Sorbitol] CTD PMID:25451566 D-glyceraldehyde increases reduction ISO RGD:732178 6480464 AKR1B1 protein results in increased reduction of Glyceraldehyde CTD PMID:19014918 daunorubicin increases reduction ISO RGD:732178 6480464 AKR1B1 protein results in increased reduction of Daunorubicin CTD PMID:10510318 decanal affects reduction ISO RGD:732178 6480464 AKR1B1 protein affects the reduction of decanaldehyde CTD PMID:11306073 decanal increases reduction ISO RGD:732178 6480464 AKR1B1 protein results in increased reduction of decanaldehyde CTD PMID:9890881 dexamethasone multiple interactions ISO RGD:736610 6480464 [1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein] results in increased expression of AKR1B3 mRNA CTD PMID:24848799 dexamethasone multiple interactions ISO RGD:732178 6480464 [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of AKR1B1 mRNA CTD PMID:28628672 dextran sulfate multiple interactions ISO RGD:736610 6480464 [titanium dioxide co-treated with Azoxymethane co-treated with Dextran Sulfate] results in decreased expression of AKR1B3 mRNA CTD PMID:29950665 dibenz[a,h]anthracene multiple interactions ISO RGD:732178 6480464 [Benzo(a)pyrene co-treated with 1 more ... CTD PMID:17690111 dibenz[a,h]anthracene multiple interactions EXP 6480464 [1 more ... CTD PMID:18711122 dibenzo[a,l]pyrene multiple interactions EXP 6480464 [1 more ... CTD PMID:18711122 dibutyl phthalate decreases expression EXP 6480464 Dibutyl Phthalate results in decreased expression of AKR1B1 mRNA CTD PMID:21266533 dioxygen multiple interactions EXP 6480464 AKR1B1 protein inhibits the reaction [Oxygen deficiency results in increased phosphorylation of EIF2A protein], AKR1B1 protein inhibits the reaction [Oxygen deficiency results in increased phosphorylation of EIF2AK3 protein] CTD PMID:19041636 dioxygen multiple interactions ISO RGD:736610 6480464 AKR1B3 protein promotes the reaction [Oxygen deficiency results in increased expression of TNF protein], AKR1B3 protein promotes the reaction [Oxygen deficiency results in increased expression of VEGFA protein] CTD PMID:30682331 dipotassium bis[mu-tartrato(4-)]diantimonate(2-) trihydrate increases expression ISO RGD:732178 6480464 Antimony Potassium Tartrate results in increased expression of AKR1B1 mRNA CTD PMID:28713220 dipotassium bis[mu-tartrato(4-)]diantimonate(2-) trihydrate decreases expression ISO RGD:732178 6480464 Antimony Potassium Tartrate results in decreased expression of AKR1B1 mRNA CTD PMID:17547211 disulfiram increases expression ISO RGD:732178 6480464 Disulfiram results in increased expression of AKR1B1 mRNA CTD PMID:20566472 diuron increases expression EXP 6480464 Diuron results in increased expression of AKR1B1 mRNA CTD PMID:21551480 , PMID:25152437 dorsomorphin multiple interactions ISO RGD:732178 6480464 [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of AKR1B1 mRNA CTD PMID:27188386 doxifluridine decreases response to substance ISO RGD:732178 6480464 AKR1B1 protein results in decreased susceptibility to doxifluridine CTD PMID:16734730 doxorubicin increases expression ISO RGD:732178 6480464 Doxorubicin results in increased expression of AKR1B1 mRNA CTD PMID:29803840 endosulfan increases expression EXP 6480464 Endosulfan results in increased expression of AKR1B1 mRNA CTD PMID:29391264 enzyme inhibitor multiple interactions ISO RGD:732178 6480464 [Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of AKR1B1 protein CTD PMID:23301498 ethanol decreases expression EXP 6480464 Ethanol results in decreased expression of AKR1B1 mRNA CTD PMID:15353170 ethanol affects splicing ISO RGD:736610 6480464 Ethanol affects the splicing of AKR1B3 mRNA CTD PMID:30319688 eugenol increases expression ISO RGD:732178 6480464 Eugenol results in increased expression of AKR1B1 mRNA CTD PMID:20566472 Fidarestat multiple interactions ISO RGD:732178 6480464 fidarestat binds to and results in decreased activity of AKR1B1 protein CTD PMID:23295227 Fidarestat affects binding ISO RGD:732178 6480464 NADP binds to AKR1B1 protein binds to fidarestat CTD PMID:23295227 fipronil increases expression EXP 6480464 fipronil results in increased expression of AKR1B1 mRNA CTD PMID:23962444 fluoranthene multiple interactions EXP 6480464 [1 more ... CTD PMID:18711122 fluoranthene multiple interactions ISO RGD:732178 6480464 [Benzo(a)pyrene co-treated with fluoranthene] affects the expression of AKR1B1 mRNA CTD PMID:17690111 flutamide increases expression EXP 6480464 Flutamide results in increased expression of AKR1B1 protein CTD PMID:17311803 folic acid multiple interactions ISO RGD:736610 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of AKR1B3 mRNA CTD PMID:20938992 fonofos increases methylation ISO RGD:732178 6480464 Fonofos results in increased methylation of AKR1B1 promoter CTD PMID:22847954 fructosamine multiple interactions ISO RGD:732178 6480464 AKR1B3 protein promotes the reaction [[ALB protein binds to Fructosamine] which results in increased secretion of TNF protein] CTD PMID:30682331 fructose multiple interactions EXP 6480464 [Fructose co-treated with bisphenol A] results in increased expression of AKR1B1 protein CTD PMID:26930160 galactose multiple interactions ISO RGD:736610 6480464 protocatechuic acid inhibits the reaction [Galactose results in increased expression of AKR1B3 mRNA] CTD PMID:22687555 galactose increases expression ISO RGD:736610 6480464 Galactose results in increased expression of AKR1B3 mRNA CTD PMID:22687555 gentamycin increases expression EXP 6480464 Gentamicins results in increased expression of AKR1B1 mRNA CTD PMID:22061828 glucose increases expression ISO RGD:736610 6480464 Glucose results in increased expression of AKR1B3 mRNA, Glucose results in increased expression of AKR1B3 protein CTD PMID:16805838 glucose multiple interactions ISO RGD:732178 6480464 AKR1B1 protein promotes the reaction [Glucose results in increased abundance of Sorbitol] CTD PMID:25451566 glutathione increases glutathionylation ISO RGD:732178 6480464 Glutathione results in increased glutathionylation of AKR1B1 protein modified form CTD PMID:19061876 glutathione increases reduction ISO RGD:732178 6480464 Glutathione results in increased reduction of AKR1B1 protein modified form CTD PMID:19061876 glutathione affects binding ISO RGD:732178 6480464 AKR1B1 protein binds to Glutathione CTD PMID:11306073 glyceraldehyde increases reduction ISO RGD:732178 6480464 AKR1B1 protein results in increased reduction of Glyceraldehyde CTD PMID:19014918 glycine betaine decreases expression EXP 6480464 Betaine results in decreased expression of AKR1B1 mRNA CTD PMID:26391144 glyoxal increases reduction ISO RGD:732178 6480464 AKR1B1 protein results in increased reduction of Glyoxal CTD PMID:10510318 glyphosate decreases expression EXP 6480464 glyphosate results in decreased expression of AKR1B1 mRNA CTD PMID:26302742 hept-2-enal increases reduction ISO RGD:732178 6480464 AKR1B1 protein results in increased reduction of 2-heptenal CTD PMID:9890881 heptanal increases reduction ISO RGD:732178 6480464 AKR1B1 protein results in increased reduction of heptanal CTD PMID:9890881 heptanal affects reduction ISO RGD:732178 6480464 AKR1B1 protein affects the reduction of heptanal CTD PMID:11306073 hexanal affects reduction ISO RGD:732178 6480464 AKR1B1 protein affects the reduction of n-hexanal, AKR1B1 protein affects the reduction of n-hexanal analog CTD PMID:11306073 hexanal increases reduction ISO RGD:732178 6480464 AKR1B1 protein results in increased reduction of n-hexanal CTD PMID:9890881 hexane increases expression ISO RGD:732178 6480464 n-hexane results in increased expression of AKR1B1 mRNA CTD PMID:20566472 hexane-2,3-dione multiple interactions ISO RGD:732178 6480464 [AKR1B1 protein results in increased reduction of 2, 3-hexanedione] which results in increased chemical synthesis of Hexanones CTD PMID:23295224 hexane-2,3-dione increases reduction ISO RGD:732178 6480464 AKR1B1 protein results in increased reduction of 2, 3-hexanedione CTD PMID:10510318 , PMID:23295224 hypochlorous acid increases expression ISO RGD:736610 6480464 Hypochlorous Acid results in increased expression of AKR1B3 mRNA CTD PMID:19376150 indometacin multiple interactions ISO RGD:732178 6480464 [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of AKR1B1 mRNA CTD PMID:28628672 isatin increases reduction ISO RGD:732178 6480464 AKR1B1 protein results in increased reduction of Isatin CTD PMID:10510318 isoeugenol increases expression ISO RGD:732178 6480464 isoeugenol results in increased expression of AKR1B1 mRNA CTD PMID:20566472 L-ascorbic acid increases reduction ISO RGD:732178 6480464 Ascorbic Acid results in increased reduction of AKR1B1 protein modified form CTD PMID:19061876 L-methionine multiple interactions ISO RGD:736610 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of AKR1B3 mRNA CTD PMID:20938992 lipopolysaccharide multiple interactions ISO RGD:736610 6480464 Lipopolysaccharides inhibits the reaction [Sodium Chloride results in increased expression of AKR1B3 mRNA] CTD PMID:23867654 lipopolysaccharide multiple interactions ISO RGD:732178 6480464 [sorbinil results in decreased activity of AKR1B1 protein] inhibits the reaction [Lipopolysaccharides results in increased abundance of Reactive Oxygen Species] more ... CTD PMID:21334316 LY294002 multiple interactions EXP 6480464 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Curcumin results in increased expression of AKR1B1 mRNA] CTD PMID:17640564 maneb multiple interactions ISO RGD:736610 6480464 [Paraquat co-treated with Maneb] results in decreased expression of AKR1B3 mRNA CTD PMID:18386188 manganese(II) chloride increases expression EXP 6480464 manganese chloride results in increased expression of AKR1B1 mRNA CTD PMID:22281203 mercury atom decreases expression ISO RGD:732178 6480464 Mercury results in decreased expression of AKR1B1 mRNA CTD PMID:17547211 mercury(0) decreases expression ISO RGD:732178 6480464 Mercury results in decreased expression of AKR1B1 mRNA CTD PMID:17547211 mercury(2+) decreases expression ISO RGD:732178 6480464 Mercury results in decreased expression of AKR1B1 mRNA CTD PMID:17547211 methapyrilene increases expression EXP 6480464 Methapyrilene results in increased expression of AKR1B1 mRNA CTD PMID:30467583 methyl salicylate increases expression ISO RGD:732178 6480464 methyl salicylate results in increased expression of AKR1B1 mRNA CTD PMID:20566472 methylglyoxal increases reduction ISO RGD:732178 6480464 AKR1B1 protein results in increased reduction of Pyruvaldehyde CTD PMID:10510318 methylphenidate decreases expression ISO RGD:736610 6480464 Methylphenidate results in decreased expression of AKR1B3 mRNA CTD PMID:22470460 methylseleninic acid increases expression ISO RGD:732178 6480464 methylselenic acid results in increased expression of AKR1B1 mRNA CTD PMID:18548127 microcystin-LR increases expression ISO RGD:736610 6480464 cyanoginosin LR results in increased expression of AKR1B3 mRNA CTD PMID:17654400 morphine decreases expression EXP 6480464 Morphine results in decreased expression of AKR1B1 protein CTD PMID:23056601 N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal increases expression ISO RGD:732178 6480464 benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of AKR1B1 mRNA CTD PMID:21215737 N-nitrosodiethylamine increases expression EXP 6480464 Diethylnitrosamine results in increased expression of AKR1B1 mRNA CTD PMID:19638242 N-nitrosodiethylamine increases expression ISO RGD:736610 6480464 Diethylnitrosamine results in increased expression of AKR1B3 mRNA CTD PMID:24535843 N-nitrosodimethylamine increases expression EXP 6480464 Dimethylnitrosamine results in increased expression of AKR1B1 mRNA CTD PMID:25380136 N-nitrosodimethylamine decreases expression ISO RGD:732178 6480464 Dimethylnitrosamine results in decreased expression of AKR1B1 mRNA CTD PMID:17547211 NADP zwitterion multiple interactions ISO RGD:732178 6480464 [AKR1B1 protein co-treated with NADP] results in increased oxidation of and affects the activity of benzo(a)pyrene 7 more ... CTD PMID:21910479 NADP zwitterion affects binding ISO RGD:732178 6480464 NADP binds to AKR1B1 protein binds to fidarestat CTD PMID:23295227 NADP zwitterion increases activity ISO RGD:732178 6480464 NADP results in increased activity of AKR1B1 protein CTD PMID:23295224 NADP(+) multiple interactions ISO RGD:732178 6480464 [AKR1B1 protein co-treated with NADP] results in increased oxidation of and affects the activity of benzo(a)pyrene 7 more ... CTD PMID:21910479 NADP(+) increases activity ISO RGD:732178 6480464 NADP results in increased activity of AKR1B1 protein CTD PMID:23295224 NADP(+) affects binding ISO RGD:732178 6480464 NADP binds to AKR1B1 protein binds to fidarestat CTD PMID:23295227 naphthalenes multiple interactions ISO RGD:732178 6480464 AKR1B1 protein results in increased reduction of and affects the activity of Naphthalenes CTD PMID:21910479 nickel dichloride decreases expression ISO RGD:732178 6480464 nickel chloride results in decreased expression of AKR1B1 mRNA CTD PMID:17547211 nickel sulfate increases expression ISO RGD:732178 6480464 nickel sulfate results in increased expression of AKR1B1 mRNA CTD PMID:20566472 non-2-enal affects reduction ISO RGD:732178 6480464 AKR1B1 protein affects the reduction of 2-nonenal CTD PMID:11306073 non-2-enal increases reduction ISO RGD:732178 6480464 AKR1B1 protein results in increased reduction of 2-nonenal CTD PMID:9890881 nonanal affects reduction ISO RGD:732178 6480464 AKR1B1 protein affects the reduction of nonanal, AKR1B1 protein affects the reduction of nonanal analog CTD PMID:11306073 nonanal increases reduction ISO RGD:732178 6480464 AKR1B1 protein results in increased reduction of nonanal CTD PMID:9890881 oct-2-enal increases reduction ISO RGD:732178 6480464 AKR1B1 protein results in increased reduction of 2-octenal CTD PMID:9890881 oct-2-enal affects reduction ISO RGD:732178 6480464 AKR1B1 protein affects the reduction of 2-octenal CTD PMID:11306073 octanal affects reduction ISO RGD:732178 6480464 AKR1B1 protein affects the reduction of caprylic aldehyde CTD PMID:11306073 oxaliplatin multiple interactions EXP 6480464 [oxaliplatin co-treated with Topotecan] results in increased expression of AKR1B1 mRNA CTD PMID:25729387 paclitaxel increases response to substance ISO RGD:732178 6480464 AKR1B1 protein results in increased susceptibility to Paclitaxel CTD PMID:16734730 paracetamol increases expression ISO RGD:732178 6480464 Acetaminophen results in increased expression of AKR1B1 mRNA CTD PMID:22230336 paraquat multiple interactions ISO RGD:736610 6480464 [Paraquat co-treated with Maneb] results in decreased expression of AKR1B3 mRNA CTD PMID:18386188 parathion increases methylation ISO RGD:732178 6480464 Parathion results in increased methylation of AKR1B1 promoter CTD PMID:22847954 pentanal increases reduction ISO RGD:732178 6480464 AKR1B1 protein results in increased reduction of pentanal CTD PMID:9890881 pentanal affects reduction ISO RGD:732178 6480464 AKR1B1 protein affects the reduction of pentanal CTD PMID:11306073 pentane-2,3-dione increases reduction ISO RGD:732178 6480464 AKR1B1 protein results in increased reduction of 2, 3-pentanedione CTD PMID:23295224 pentane-2,3-dione multiple interactions ISO RGD:732178 6480464 [AKR1B1 protein results in increased reduction of 2, 3-pentanedione] which results in increased chemical synthesis of Pentanones CTD PMID:23295224 phenethyl caffeate decreases activity ISO RGD:732178 6480464 caffeic acid phenethyl ester results in decreased activity of AKR1B1 protein CTD PMID:27163852 phenobarbital affects expression ISO RGD:732178 6480464 Phenobarbital affects the expression of AKR1B1 mRNA CTD PMID:19084549 phenobarbital affects expression ISO RGD:736610 6480464 Phenobarbital affects the expression of AKR1B3 mRNA CTD PMID:23091169 Phenylglyoxal increases reduction ISO RGD:732178 6480464 AKR1B1 protein results in increased reduction of Phenylglyoxal CTD PMID:10510318 pirinixic acid decreases activity ISO RGD:732178 6480464 pirinixic acid results in decreased activity of AKR1B1 protein CTD PMID:17194029 potassium dichromate decreases expression ISO RGD:732178 6480464 Potassium Dichromate results in decreased expression of AKR1B1 mRNA CTD PMID:17547211 propan-2-ol increases expression ISO RGD:732178 6480464 2-Propanol results in increased expression of AKR1B1 mRNA CTD PMID:20566472 propanal affects reduction ISO RGD:732178 6480464 AKR1B1 protein affects the reduction of propionaldehyde analog CTD PMID:11306073 propanal increases reduction ISO RGD:732178 6480464 AKR1B1 protein results in increased reduction of propionaldehyde CTD PMID:9890881 prostaglandin E2 multiple interactions ISO RGD:732178 6480464 [sorbinil results in decreased activity of AKR1B1 protein] inhibits the reaction [Lipopolysaccharides results in increased secretion of Dinoprostone], [zopolrestat results in decreased activity of AKR1B1 protein] inhibits the reaction [Antigens, Plant results in increased secretion of Dinoprostone] CTD PMID:21334316 pterostilbene multiple interactions ISO RGD:736610 6480464 pterostilbene inhibits the reaction [Azoxymethane results in increased expression of AKR1B3 mRNA], pterostilbene inhibits the reaction [Azoxymethane results in increased expression of AKR1B3 protein] CTD PMID:21355597 quercetin increases expression ISO RGD:732178 6480464 Quercetin results in increased expression of AKR1B1 mRNA CTD PMID:21632981 rac-lactic acid increases expression ISO RGD:732178 6480464 Lactic Acid results in increased expression of AKR1B1 mRNA CTD PMID:20566472 reactive oxygen species multiple interactions ISO RGD:732178 6480464 [sorbinil results in decreased activity of AKR1B1 protein] inhibits the reaction [Lipopolysaccharides results in increased abundance of Reactive Oxygen Species], [zopolrestat results in decreased activity of AKR1B1 protein] inhibits the reaction [Antigens, Plant results in increased abundance of Reactive Oxygen Species] CTD PMID:21334316 resveratrol multiple interactions ISO RGD:736610 6480464 resveratrol inhibits the reaction [Azoxymethane results in increased expression of AKR1B3 mRNA], resveratrol inhibits the reaction [Azoxymethane results in increased expression of AKR1B3 protein] CTD PMID:21355597 resveratrol increases expression EXP 6480464 resveratrol results in increased expression of AKR1B1 mRNA CTD PMID:25905778 SB 203580 multiple interactions EXP 6480464 SB 203580 inhibits the reaction [Curcumin results in increased expression of AKR1B1 mRNA] CTD PMID:17640564 SB 431542 multiple interactions ISO RGD:732178 6480464 [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of AKR1B1 mRNA CTD PMID:27188386 silicon dioxide increases secretion ISO RGD:732178 6480464 Silicon Dioxide analog results in increased secretion of AKR1B1 protein CTD PMID:25895662 sodium arsenate increases expression ISO RGD:732178 6480464 sodium arsenate results in increased expression of AKR1B1 mRNA CTD PMID:12727804 sodium arsenite increases expression EXP 6480464 sodium arsenite results in increased expression of AKR1B1 protein CTD PMID:16456883 sodium arsenite multiple interactions EXP 6480464 Benzo(a)pyrene promotes the reaction [sodium arsenite results in increased expression of AKR1B1 protein], sodium arsenite promotes the reaction [Benzo(a)pyrene results in increased expression of AKR1B1 protein] CTD PMID:16456883 sodium arsenite increases expression ISO RGD:732178 6480464 sodium arsenite results in increased expression of AKR1B1 mRNA CTD PMID:20886546 , PMID:28713220 sodium chloride increases expression ISO RGD:736610 6480464 Sodium Chloride results in increased expression of AKR1B3 mRNA CTD PMID:23867654 sodium chloride multiple interactions ISO RGD:736610 6480464 Lipopolysaccharides inhibits the reaction [Sodium Chloride results in increased expression of AKR1B3 mRNA] CTD PMID:23867654 sodium dodecyl sulfate increases expression ISO RGD:732178 6480464 Sodium Dodecyl Sulfate results in increased expression of AKR1B1 mRNA CTD PMID:20566472 sorbinil decreases activity ISO RGD:732178 6480464 sorbinil results in decreased activity of AKR1B1 protein CTD PMID:21334316 sorbinil multiple interactions ISO RGD:732178 6480464 [sorbinil results in decreased activity of AKR1B1 protein] inhibits the reaction [Lipopolysaccharides results in increased abundance of Reactive Oxygen Species] more ... CTD PMID:21334316 , PMID:28137510 streptozocin multiple interactions ISO RGD:732178 6480464 Streptozocin inhibits the reaction [AKR1B1 protein results in increased phosphorylation of MAPK1 protein] more ... CTD PMID:25541468 sulindac multiple interactions ISO RGD:732178 6480464 Sulindac analog binds to and results in decreased activity of AKR1B1 protein, Sulindac binds to and results in decreased activity of AKR1B1 protein CTD PMID:25532697 sulindac sulfone multiple interactions ISO RGD:732178 6480464 sulindac sulfone binds to and results in decreased activity of AKR1B1 protein CTD PMID:25532697 temozolomide affects response to substance ISO RGD:732178 6480464 AKR1B1 mRNA affects the susceptibility to temozolomide CTD PMID:16365179 terbufos increases methylation ISO RGD:732178 6480464 terbufos results in increased methylation of AKR1B1 promoter CTD PMID:22847954 titanium dioxide decreases phosphorylation ISO RGD:732178 6480464 titanium dioxide results in decreased phosphorylation of AKR1B1 protein CTD PMID:21439344 titanium dioxide multiple interactions ISO RGD:736610 6480464 [titanium dioxide co-treated with Azoxymethane co-treated with Dextran Sulfate] results in decreased expression of AKR1B3 mRNA CTD PMID:29950665 topotecan multiple interactions EXP 6480464 [oxaliplatin co-treated with Topotecan] results in increased expression of AKR1B1 mRNA CTD PMID:25729387 trans-isoeugenol increases expression ISO RGD:732178 6480464 isoeugenol results in increased expression of AKR1B1 mRNA CTD PMID:20566472 tributylstannane increases expression ISO RGD:736610 6480464 tributyltin results in increased expression of AKR1B3 mRNA CTD PMID:24848799 valproic acid decreases methylation ISO RGD:732178 6480464 Valproic Acid results in decreased methylation of AKR1B1 gene CTD PMID:29154799 valproic acid decreases expression ISO RGD:732178 6480464 Valproic Acid results in decreased expression of AKR1B1 mRNA CTD PMID:29501571 valproic acid multiple interactions ISO RGD:732178 6480464 [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of AKR1B1 mRNA CTD PMID:27188386 valproic acid increases expression ISO RGD:732178 6480464 Valproic Acid results in increased expression of AKR1B1 mRNA, Valproic Acid results in increased expression of AKR1B1 protein CTD PMID:23179753 more ... valproic acid affects expression ISO RGD:732178 6480464 Valproic Acid affects the expression of AKR1B1 mRNA CTD PMID:25979313 valproic acid affects expression ISO RGD:736610 6480464 Valproic Acid affects the expression of AKR1B3 mRNA CTD PMID:17963808 vitamin E increases expression EXP 6480464 alpha-Tocopherol results in increased expression of AKR1B1 mRNA CTD PMID:16908007 vitamin E increases expression ISO RGD:732178 6480464 Vitamin E results in increased expression of AKR1B1 mRNA CTD PMID:19244175 zoledronic acid increases expression ISO RGD:732178 6480464 zoledronic acid results in increased expression of AKR1B1 mRNA CTD PMID:24714768
Gene-Chemical Interaction Annotations
