AKR1B10 (aldo-keto reductase family 1 member B10) - Rat Genome Database

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Gene: AKR1B10 (aldo-keto reductase family 1 member B10) Homo sapiens
Analyze
Symbol: AKR1B10
Name: aldo-keto reductase family 1 member B10
RGD ID: 1317959
HGNC Page HGNC:382
Description: Enables geranylgeranyl reductase activity; oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; and retinal dehydrogenase activity. Involved in cellular detoxification of aldehyde; glycoside metabolic process; and terpenoid metabolic process. Located in extracellular region and lysosome.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: AKR1B11; AKR1B12; aldo-keto reductase family 1, member B10 (aldose reductase); aldo-keto reductase family 1, member B11 (aldose reductase-like); aldose reductase-like 1; aldose reductase-like peptide; aldose reductase-related protein; ALDRLn; ARL-1; ARL1; ARP; hARP; HIS; HSI; MGC14103; SI reductase; small intestine reductase
RGD Orthologs
Mouse
Rat
Bonobo
Alliance Orthologs
More Info more info ...
Related Pseudogenes: AKR1B10P1   AKR1B10P2  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh387134,527,567 - 134,541,412 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl7134,527,567 - 134,541,412 (+)EnsemblGRCh38hg38GRCh38
GRCh377134,212,319 - 134,226,164 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 367133,862,939 - 133,876,700 (+)NCBINCBI36Build 36hg18NCBI36
Build 347133,669,653 - 133,683,413NCBI
Celera7128,949,765 - 128,963,585 (+)NCBICelera
Cytogenetic Map7q33NCBI
HuRef7128,514,188 - 128,528,007 (+)NCBIHuRef
CHM1_17134,146,625 - 134,160,442 (+)NCBICHM1_1
T2T-CHM13v2.07135,835,650 - 135,849,492 (+)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v27133,556,663 - 133,570,483 (+)NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(4-oxo-3-\{[5-(trifluoromethyl)-1,3-benzothiazol-2-yl]methyl\}-3,4-dihydrophthalazin-1-yl)acetic acid  (EXP)
(E)-cinnamyl alcohol  (EXP)
(E,E)-2,4-hexadienal  (EXP)
(R)-acetoin  (EXP)
1,2-dimethylhydrazine  (ISO)
1-chloro-2,4-dinitrobenzene  (EXP)
13-dihydrodaunorubicin  (EXP)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-(chloromethyl)pyridine  (EXP)
2-acetamidofluorene  (EXP,ISO)
2-hexenal  (EXP)
2-hydroxypropanoic acid  (EXP)
2-palmitoylglycerol  (EXP)
2-tert-butylhydroquinone  (EXP)
3-chloropropane-1,2-diol  (ISO)
3-Hydroxybenzo[a]pyrene  (EXP)
3-methyl-3H-imidazo[4,5-f]quinolin-2-amine  (EXP)
3-phenylprop-2-enal  (EXP)
4,4'-methylene-bis-(2-chloroaniline)  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-hydroperoxycyclophosphamide  (EXP)
4-hydroxynon-2-enal  (EXP)
4-hydroxyphenyl retinamide  (ISO)
4-methylpentanal  (EXP)
4-nitro-1,2-phenylenediamine  (EXP)
5-fluorouracil  (EXP)
7,12-dimethyltetraphene  (EXP)
9,10-phenanthroquinone  (EXP)
9-cis-retinal  (EXP)
[6]-Shogaol  (EXP)
acetoin  (EXP)
acrolein  (EXP,ISO)
actinomycin D  (EXP)
adhumulone  (EXP)
aflatoxin B1  (EXP,ISO)
all-trans-4-oxoretinal  (EXP)
all-trans-dehydroretinal  (EXP)
all-trans-retinal  (EXP)
all-trans-retinol  (EXP)
Aloe emodin  (EXP)
alpha-hexylcinnamaldehyde  (EXP)
amoxicillin  (EXP)
ampicillin  (EXP)
anthranilic acid  (EXP)
antimonite  (EXP)
arsane  (EXP)
arsenic atom  (EXP)
arsenite(3-)  (EXP)
arsenous acid  (EXP)
atrazine  (ISO)
Augmentin  (EXP)
azathioprine  (EXP)
Bandrowski's base  (EXP)
benzalkonium chloride  (EXP)
benzidine  (EXP)
benzo[a]pyrene  (EXP,ISO)
Benzo[a]pyrene-7,8-diol  (EXP)
benzo[a]pyrene-7,8-dione  (EXP)
benzoic acid  (EXP)
beta-lapachone  (EXP)
bis(2-chloroethyl) sulfide  (EXP)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP,ISO)
bortezomib  (EXP)
butane-2,3-diol  (EXP)
butane-2,3-dione  (EXP)
cadmium atom  (EXP)
cadmium sulfate  (EXP)
captan  (ISO)
carbamazepine  (EXP)
carbon nanotube  (ISO)
chlorambucil  (EXP)
chromium(6+)  (EXP)
chrysin  (EXP)
cinnamyl alcohol  (EXP)
ciprofibrate  (EXP)
cisplatin  (EXP)
clavulanic acid  (EXP)
Clofop  (EXP)
cobalt dichloride  (EXP)
Cohumulone  (EXP)
copper atom  (EXP)
copper(0)  (EXP)
copper(II) chloride  (EXP)
copper(II) sulfate  (EXP)
crotonaldehyde  (EXP)
cyclosporin A  (EXP)
D-glyceraldehyde  (EXP)
daunorubicin  (EXP)
DDT  (EXP)
diarsenic trioxide  (EXP)
dibenzo[a,l]pyrene  (EXP)
diethyl maleate  (EXP)
diethylstilbestrol  (EXP)
dipotassium bis[mu-tartrato(4-)]diantimonate(2-) trihydrate  (EXP)
diquat  (EXP)
disulfiram  (EXP)
dorsomorphin  (EXP)
doxorubicin  (EXP)
emodin  (EXP)
ethanol  (ISO)
ethoxyquin  (EXP)
Ethyl 1-benzyl-3-hydroxy- 2-oxo[5H]pyrrole-4-carboxylate  (EXP)
Ethyl acrylate  (EXP)
eugenol  (EXP)
farnesal  (EXP)
farnesol  (EXP)
fenofibrate  (EXP)
Fidarestat  (EXP)
flucloxacillin  (EXP)
folpet  (ISO)
formaldehyde  (EXP)
formononetin  (EXP)
Frangulin A  (EXP)
Frangulin B  (EXP)
furan  (ISO)
gemfibrozil  (EXP)
gentamycin  (ISO)
geranylgeraniol  (EXP)
glyceraldehyde  (EXP)
gold atom  (EXP)
gold(0)  (EXP)
hexane  (EXP)
hexane-2,3-dione  (EXP)
hydrogen peroxide  (EXP)
hydroquinone  (EXP)
indan-1-ol  (EXP)
indometacin  (ISO)
isoeugenol  (EXP)
isoniazide  (EXP)
Isoxanthohumol  (EXP)
L-ascorbic acid  (EXP)
lead diacetate  (EXP)
lead(II) chloride  (EXP)
Licochalcone B  (EXP)
lipopolysaccharide  (EXP)
LY294002  (EXP)
menadione  (EXP)
methyl salicylate  (EXP)
methylisothiazolinone  (EXP)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (EXP)
N-methyl-N-nitrosourea  (ISO)
N-nitrosodiethylamine  (ISO)
N-Nitrosopyrrolidine  (EXP)
NADP zwitterion  (EXP)
NADP(+)  (EXP)
naphthalenes  (EXP)
nickel atom  (EXP)
nickel sulfate  (EXP)
nitrososulfamethoxazole  (EXP)
Nutlin-3  (EXP)
O-methyleugenol  (EXP)
ochratoxin A  (EXP,ISO)
oleanolic acid  (EXP)
p-chloromercuribenzenesulfonic acid  (EXP)
para-Cresidine  (EXP)
paracetamol  (EXP,ISO)
paraquat  (EXP)
pazopanib  (EXP)
pentane-2,3-dione  (EXP)
perfluorohexanesulfonic acid  (ISO)
perfluorooctane-1-sulfonic acid  (EXP)
perfluorooctanoic acid  (EXP)
phenethyl caffeate  (EXP)
phenobarbital  (EXP)
phenol  (EXP)
phenylmercury acetate  (EXP)
phorbol 13-acetate 12-myristate  (EXP)
picoxystrobin  (EXP)
pimecrolimus  (EXP)
pirinixic acid  (EXP,ISO)
potassium bromate  (ISO)
progesterone  (EXP)
propan-2-ol  (EXP)
propiconazole  (EXP)
quercetin  (EXP)
quinolin-8-ol  (EXP)
rac-lactic acid  (EXP)
reserpine  (EXP)
resorcinol  (EXP)
resveratrol  (ISO)
rifampicin  (EXP)
rotenone  (EXP)
S-(1,2-dichlorovinyl)-L-cysteine  (EXP)
SB 431542  (EXP)
silicon dioxide  (EXP,ISO)
silver atom  (EXP)
silver(0)  (EXP)
sodium arsenate  (EXP)
sodium arsenite  (EXP,ISO)
sodium dodecyl sulfate  (EXP)
sorbinil  (EXP)
sulforaphane  (EXP)
sulindac  (EXP)
sulindac sulfone  (EXP)
tebuconazole  (EXP)
temozolomide  (EXP)
tert-butyl hydroperoxide  (EXP)
tetraphene  (EXP)
thioacetamide  (ISO)
titanium dioxide  (EXP)
trans-isoeugenol  (EXP)
Tributyltin oxide  (EXP)
trichloroethene  (ISO)
Triptolide  (ISO)
troglitazone  (EXP)
urethane  (EXP)
valproic acid  (EXP)
vitamin E  (EXP)

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Human Phenotype
References

References - curated
# Reference Title Reference Citation
1. Properties and tissue distribution of a novel aldo-keto reductase encoding in a rat gene (Akr1b10). Endo S, etal., Arch Biochem Biophys. 2010 Nov 15;503(2):230-7. Epub 2010 Aug 13.
2. GOAs Human GO annotations GOA_HUMAN data from the GO Consortium
3. Aldo-keto reductases and bioactivation/detoxication. Jin Y and Penning TM, Annu Rev Pharmacol Toxicol. 2007;47:263-92.
4. Meta-analysis of three diabetes population studies: association of inactive ALDH2 genotype with maternal inheritance of diabetes. Murata C, etal., Diabetes Res Clin Pract. 2004 Dec;66 Suppl 1:S145-7.
5. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
6. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
8. ALDH2/ADH2 polymorphism associated with vasculopathy and neuropathy in type 2 diabetes. Suzuki Y, etal., Alcohol Clin Exp Res. 2004 Aug;28(8 Suppl Proceedings):111S-116S.
9. Aldehyde dehydrogenase 2 genotype in type 1 diabetes mellitus. Suzuki Y, etal., Diabetes Res Clin Pract. 2003 May;60(2):139-41.
Additional References at PubMed
PMID:8889548   PMID:9537432   PMID:9565553   PMID:9765596   PMID:11703436   PMID:12365083   PMID:12477932   PMID:12732097   PMID:12882871   PMID:15489334   PMID:15745835   PMID:15928807  
PMID:15936242   PMID:16127462   PMID:16204895   PMID:17209433   PMID:17300864   PMID:17425679   PMID:17597105   PMID:17905306   PMID:18056116   PMID:18087047   PMID:18325492   PMID:18358633  
PMID:18396902   PMID:18788756   PMID:19013440   PMID:19028477   PMID:19236911   PMID:19464995   PMID:19563777   PMID:19643728   PMID:19913121   PMID:20007578   PMID:20036025   PMID:20586184  
PMID:20628086   PMID:20705797   PMID:20837989   PMID:20943077   PMID:21044950   PMID:21187079   PMID:21277289   PMID:21317765   PMID:21329684   PMID:21585341   PMID:21645211   PMID:21672310  
PMID:21851338   PMID:21873635   PMID:22014576   PMID:22198799   PMID:22222635   PMID:22329800   PMID:22498646   PMID:22681639   PMID:23146748   PMID:23376485   PMID:23438482   PMID:23912490  
PMID:23975544   PMID:24100137   PMID:24140838   PMID:24217247   PMID:24391771   PMID:24406159   PMID:24656094   PMID:25156503   PMID:25289770   PMID:25304374   PMID:25324306   PMID:25463304  
PMID:25487531   PMID:25532697   PMID:25686905   PMID:25887478   PMID:26186194   PMID:26209609   PMID:26344197   PMID:26496610   PMID:26758591   PMID:26835713   PMID:26948042   PMID:26969882  
PMID:27025872   PMID:27239845   PMID:27248472   PMID:27417252   PMID:27672277   PMID:28003428   PMID:28181486   PMID:28219640   PMID:28232277   PMID:28301069   PMID:28514442   PMID:28929377  
PMID:29079172   PMID:29204449   PMID:29383608   PMID:29617059   PMID:29846015   PMID:30021884   PMID:30038373   PMID:30328412   PMID:30504401   PMID:30707282   PMID:31028727   PMID:31034948  
PMID:31221959   PMID:31237374   PMID:31436131   PMID:31894008   PMID:32097409   PMID:32615540   PMID:32628753   PMID:33024031   PMID:33105932   PMID:33758077   PMID:33767586   PMID:33832153  
PMID:33913495   PMID:33945128   PMID:33961781   PMID:34027794   PMID:34035231   PMID:34140644   PMID:34521883   PMID:34552036   PMID:34732716   PMID:35163833   PMID:35178834   PMID:35271311  
PMID:35562734   PMID:35563425   PMID:35831314   PMID:35920984   PMID:35944360   PMID:36217030   PMID:36244648   PMID:36661656   PMID:37039038   PMID:37500927   PMID:37587486   PMID:37717980  
PMID:37823316   PMID:38662158   PMID:38718846   PMID:38802416   PMID:39177716   PMID:39358380  


Genomics

Comparative Map Data
AKR1B10
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh387134,527,567 - 134,541,412 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl7134,527,567 - 134,541,412 (+)EnsemblGRCh38hg38GRCh38
GRCh377134,212,319 - 134,226,164 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 367133,862,939 - 133,876,700 (+)NCBINCBI36Build 36hg18NCBI36
Build 347133,669,653 - 133,683,413NCBI
Celera7128,949,765 - 128,963,585 (+)NCBICelera
Cytogenetic Map7q33NCBI
HuRef7128,514,188 - 128,528,007 (+)NCBIHuRef
CHM1_17134,146,625 - 134,160,442 (+)NCBICHM1_1
T2T-CHM13v2.07135,835,650 - 135,849,492 (+)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v27133,556,663 - 133,570,483 (+)NCBI
Akr1b10
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39634,361,182 - 34,373,884 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl634,361,153 - 34,373,885 (+)EnsemblGRCm39 Ensembl
GRCm38634,384,247 - 34,396,949 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl634,384,218 - 34,396,950 (+)EnsemblGRCm38mm10GRCm38
MGSCv37634,334,247 - 34,346,949 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36634,314,405 - 34,327,107 (+)NCBIMGSCv36mm8
Celera634,380,662 - 34,393,359 (+)NCBICelera
Cytogenetic Map6B1NCBI
cM Map614.93NCBI
Akr1b10
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8464,005,632 - 64,027,860 (+)NCBIGRCr8
mRatBN7.2463,038,459 - 63,060,336 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl463,040,169 - 63,053,852 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx467,989,273 - 68,004,664 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0463,904,967 - 63,920,356 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0462,307,393 - 62,322,778 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0461,813,265 - 61,830,371 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl461,771,970 - 61,828,657 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0461,550,785 - 61,568,072 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4461,755,871 - 61,771,264 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1462,032,000 - 62,047,393 (+)NCBI
Celera458,091,866 - 58,107,253 (+)NCBICelera
Cytogenetic Map4q22NCBI
AKR1B10
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v26171,343,443 - 171,357,364 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1723,353,774 - 23,367,619 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v07126,486,012 - 126,499,852 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.17138,992,802 - 139,006,042 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl7138,992,835 - 139,006,003 (+)Ensemblpanpan1.1panPan2

Variants

.
Variants in AKR1B10
30 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 7q32.1-36.3(chr7:129310166-159282390)x3 copy number gain See cases [RCV000050876] Chr7:129310166..159282390 [GRCh38]
Chr7:128950007..159075079 [GRCh37]
Chr7:128737243..158767840 [NCBI36]
Chr7:7q32.1-36.3
pathogenic
GRCh38/hg38 7q32.3-36.3(chr7:132850196-159325876)x3 copy number gain See cases [RCV000051101] Chr7:132850196..159325876 [GRCh38]
Chr7:132534956..159118566 [GRCh37]
Chr7:132185496..158811327 [NCBI36]
Chr7:7q32.3-36.3
pathogenic
GRCh38/hg38 7p22.3-q36.3(chr7:53985-159282531)x1 copy number loss See cases [RCV000052250] Chr7:53985..159282531 [GRCh38]
Chr7:53985..159075220 [GRCh37]
Chr7:149068..158767981 [NCBI36]
Chr7:7p22.3-q36.3
pathogenic
GRCh38/hg38 7q32.3-36.1(chr7:132023155-149309794)x1 copy number loss Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000054172]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000054172]|See cases [RCV000054172] Chr7:132023155..149309794 [GRCh38]
Chr7:131707914..149006885 [GRCh37]
Chr7:131358454..148637818 [NCBI36]
Chr7:7q32.3-36.1
pathogenic
NM_020299.4(AKR1B10):c.400G>A (p.Gly134Arg) single nucleotide variant Malignant melanoma [RCV000061563] Chr7:134533052 [GRCh38]
Chr7:134217804 [GRCh37]
Chr7:133868344 [NCBI36]
Chr7:7q33
not provided
NM_020299.4(AKR1B10):c.691G>A (p.Asp231Asn) single nucleotide variant Malignant melanoma [RCV000061564] Chr7:134537611 [GRCh38]
Chr7:134222363 [GRCh37]
Chr7:133872903 [NCBI36]
Chr7:7q33
not provided
NM_020299.4(AKR1B10):c.730A>C (p.Thr244Pro) single nucleotide variant Malignant melanoma [RCV000061565] Chr7:134537650 [GRCh38]
Chr7:134222402 [GRCh37]
Chr7:133872942 [NCBI36]
Chr7:7q33
not provided
GRCh38/hg38 7p22.3-q36.3(chr7:54185-159282390)x1 copy number loss See cases [RCV000135401] Chr7:54185..159282390 [GRCh38]
Chr7:54185..159075079 [GRCh37]
Chr7:149268..158767840 [NCBI36]
Chr7:7p22.3-q36.3
pathogenic
GRCh38/hg38 7q21.3-36.3(chr7:97419852-158923762)x3 copy number gain See cases [RCV000136717] Chr7:97419852..158923762 [GRCh38]
Chr7:97049164..158716453 [GRCh37]
Chr7:96887100..158409214 [NCBI36]
Chr7:7q21.3-36.3
pathogenic
GRCh38/hg38 7q31.2-33(chr7:117326805-134790689)x1 copy number loss See cases [RCV000138226] Chr7:117326805..134790689 [GRCh38]
Chr7:116966859..134475440 [GRCh37]
Chr7:116754095..134125980 [NCBI36]
Chr7:7q31.2-33
pathogenic
GRCh38/hg38 7q31.32-36.3(chr7:121863759-159335865)x3 copy number gain See cases [RCV000138847] Chr7:121863759..159335865 [GRCh38]
Chr7:121503813..159128555 [GRCh37]
Chr7:121291049..158821316 [NCBI36]
Chr7:7q31.32-36.3
pathogenic
GRCh38/hg38 7q32.3-36.3(chr7:132444095-159335866)x3 copy number gain See cases [RCV000139654] Chr7:132444095..159335866 [GRCh38]
Chr7:132128854..159128556 [GRCh37]
Chr7:131779394..158821317 [NCBI36]
Chr7:7q32.3-36.3
pathogenic
GRCh38/hg38 7q31.2-36.3(chr7:115459015-159325817)x3 copy number gain See cases [RCV000141413] Chr7:115459015..159325817 [GRCh38]
Chr7:115099069..159118507 [GRCh37]
Chr7:114886305..158811268 [NCBI36]
Chr7:7q31.2-36.3
pathogenic
GRCh38/hg38 7q32.3-36.3(chr7:131228764-159335866)x3 copy number gain See cases [RCV000142802] Chr7:131228764..159335866 [GRCh38]
Chr7:130913523..159128556 [GRCh37]
Chr7:130564063..158821317 [NCBI36]
Chr7:7q32.3-36.3
pathogenic
GRCh38/hg38 7q32.3-36.3(chr7:131171478-159327017)x3 copy number gain See cases [RCV000143754] Chr7:131171478..159327017 [GRCh38]
Chr7:130856237..159119707 [GRCh37]
Chr7:130506777..158812468 [NCBI36]
Chr7:7q32.3-36.3
pathogenic
GRCh38/hg38 7q32.3-36.3(chr7:132438072-159327017)x3 copy number gain See cases [RCV000143707] Chr7:132438072..159327017 [GRCh38]
Chr7:132122831..159119707 [GRCh37]
Chr7:131773371..158812468 [NCBI36]
Chr7:7q32.3-36.3
pathogenic
TMEM106B-BRAF fusion deletion Pleomorphic xanthoastrocytoma [RCV000454357] Chr7:12258147..140494267 [GRCh37]
Chr7:7p21.3-q34
pathogenic
GRCh37/hg19 7p22.3-q36.3(chr7:43360-159119707)x1 copy number loss See cases [RCV000446044] Chr7:43360..159119707 [GRCh37]
Chr7:7p22.3-q36.3
pathogenic
GRCh37/hg19 7q22.1-36.3(chr7:98969247-159119707)x3 copy number gain See cases [RCV000447709] Chr7:98969247..159119707 [GRCh37]
Chr7:7q22.1-36.3
pathogenic
GRCh37/hg19 7q32.3-34(chr7:131642114-139107211)x1 copy number loss See cases [RCV000448552] Chr7:131642114..139107211 [GRCh37]
Chr7:7q32.3-34
pathogenic
GRCh37/hg19 7q33-36.3(chr7:133799185-159119707)x1 copy number loss See cases [RCV000448836] Chr7:133799185..159119707 [GRCh37]
Chr7:7q33-36.3
pathogenic
GRCh37/hg19 7q32.1-34(chr7:127295698-139524358)x1 copy number loss See cases [RCV000447722] Chr7:127295698..139524358 [GRCh37]
Chr7:7q32.1-34
pathogenic
GRCh37/hg19 7q32.1-36.3(chr7:128276078-159119707)x3 copy number gain See cases [RCV000447956] Chr7:128276078..159119707 [GRCh37]
Chr7:7q32.1-36.3
pathogenic
GRCh37/hg19 7p22.3-q36.3(chr7:43361-159119707) copy number gain See cases [RCV000510686] Chr7:43361..159119707 [GRCh37]
Chr7:7p22.3-q36.3
pathogenic
GRCh37/hg19 7p22.3-q36.3(chr7:43361-159119707)x3 copy number gain See cases [RCV000511549] Chr7:43361..159119707 [GRCh37]
Chr7:7p22.3-q36.3
pathogenic
GRCh37/hg19 7q33(chr7:133230189-137972605)x1 copy number loss not provided [RCV000682906] Chr7:133230189..137972605 [GRCh37]
Chr7:7q33
pathogenic
GRCh37/hg19 7q22.1-36.3(chr7:98693388-159119707)x3 copy number gain not provided [RCV000682911] Chr7:98693388..159119707 [GRCh37]
Chr7:7q22.1-36.3
pathogenic
GRCh37/hg19 7p22.3-q36.3(chr7:10704-159122532)x3 copy number gain not provided [RCV000746278] Chr7:10704..159122532 [GRCh37]
Chr7:7p22.3-q36.3
pathogenic
GRCh37/hg19 7p22.3-q36.3(chr7:44935-159126310)x3 copy number gain not provided [RCV000746280] Chr7:44935..159126310 [GRCh37]
Chr7:7p22.3-q36.3
pathogenic
Single allele complex Renal transitional cell carcinoma [RCV000754611] Chr7:129367205..140482957 [GRCh37]
Chr7:7q32.2-34
likely pathogenic
GRCh37/hg19 7q33(chr7:134202349-134305426)x1 copy number loss not provided [RCV000747058] Chr7:134202349..134305426 [GRCh37]
Chr7:7q33
benign
GRCh37/hg19 7p22.3-q36.3(chr7:10365-159119707)x3 copy number gain not provided [RCV000848126] Chr7:10365..159119707 [GRCh37]
Chr7:7p22.3-q36.3
pathogenic
GRCh37/hg19 7q32.1-36.3(chr7:128312450-159119220) copy number gain not provided [RCV000767558] Chr7:128312450..159119220 [GRCh37]
Chr7:7q32.1-36.3
pathogenic
GRCh37/hg19 7q32.3-36.3(chr7:131414604-159126310)x1 copy number loss See cases [RCV001007432] Chr7:131414604..159126310 [GRCh37]
Chr7:7q32.3-36.3
pathogenic
GRCh37/hg19 7q33(chr7:133895591-134317660)x1 copy number loss not provided [RCV000849810] Chr7:133895591..134317660 [GRCh37]
Chr7:7q33
uncertain significance
GRCh37/hg19 7q32.3-36.3(chr7:130592554-159119707)x3 copy number gain not provided [RCV000849569] Chr7:130592554..159119707 [GRCh37]
Chr7:7q32.3-36.3
pathogenic
GRCh37/hg19 7q31.1-36.3(chr7:109251060-159119707)x3 copy number gain not provided [RCV001005994] Chr7:109251060..159119707 [GRCh37]
Chr7:7q31.1-36.3
pathogenic
GRCh37/hg19 7q33-35(chr7:133848099-145814115)x1 copy number loss Hypertelorism [RCV001801200] Chr7:133848099..145814115 [GRCh37]
Chr7:7q33-35
pathogenic
GRCh37/hg19 7q33(chr7:134128369-134656514) copy number gain not specified [RCV002053734] Chr7:134128369..134656514 [GRCh37]
Chr7:7q33
uncertain significance
GRCh37/hg19 7q31.33-33(chr7:124103982-134693590) copy number loss not specified [RCV002053726] Chr7:124103982..134693590 [GRCh37]
Chr7:7q31.33-33
pathogenic
GRCh37/hg19 7q32.1-34(chr7:127295698-139524358) copy number loss not specified [RCV002053727] Chr7:127295698..139524358 [GRCh37]
Chr7:7q32.1-34
pathogenic
GRCh37/hg19 7q33-36.3(chr7:133851002-159119707)x3 copy number gain not provided [RCV001834520] Chr7:133851002..159119707 [GRCh37]
Chr7:7q33-36.3
pathogenic
NC_000007.13:g.(?_130781014)_(150301047_?)del deletion not provided [RCV003116360] Chr7:130781014..150301047 [GRCh37]
Chr7:7q32.3-36.1
pathogenic
Single allele complex Ring chromosome 7 [RCV002280646] Chr7:43360..159119707 [GRCh37]
Chr7:7p22.3-q36.3
pathogenic
GRCh37/hg19 7p22.3-q36.3(chr7:56604613-96692931)x1 copy number loss See cases [RCV002287832] Chr7:56604613..96692931 [GRCh37]
Chr7:7p22.3-q36.3
uncertain significance
GRCh37/hg19 7q32.3-36.1(chr7:131779213-149042734)x1 copy number loss not provided [RCV002472560] Chr7:131779213..149042734 [GRCh37]
Chr7:7q32.3-36.1
pathogenic
NM_020299.5(AKR1B10):c.431C>T (p.Ala144Val) single nucleotide variant not specified [RCV004078602] Chr7:134536651 [GRCh38]
Chr7:134221403 [GRCh37]
Chr7:7q33
uncertain significance
NM_020299.5(AKR1B10):c.778G>T (p.Val260Phe) single nucleotide variant not specified [RCV004227499] Chr7:134538230 [GRCh38]
Chr7:134222982 [GRCh37]
Chr7:7q33
uncertain significance
NM_020299.5(AKR1B10):c.410C>T (p.Thr137Met) single nucleotide variant not specified [RCV004145654] Chr7:134533062 [GRCh38]
Chr7:134217814 [GRCh37]
Chr7:7q33
uncertain significance
NM_020299.5(AKR1B10):c.758A>G (p.His253Arg) single nucleotide variant not specified [RCV004097087] Chr7:134538210 [GRCh38]
Chr7:134222962 [GRCh37]
Chr7:7q33
uncertain significance
NM_020299.5(AKR1B10):c.803C>A (p.Ala268Glu) single nucleotide variant not specified [RCV004159747] Chr7:134538255 [GRCh38]
Chr7:134223007 [GRCh37]
Chr7:7q33
uncertain significance
NM_020299.5(AKR1B10):c.498G>T (p.Gln166His) single nucleotide variant not specified [RCV004094036] Chr7:134536718 [GRCh38]
Chr7:134221470 [GRCh37]
Chr7:7q33
uncertain significance
NM_020299.5(AKR1B10):c.752G>A (p.Arg251His) single nucleotide variant not specified [RCV004232263] Chr7:134538204 [GRCh38]
Chr7:134222956 [GRCh37]
Chr7:7q33
uncertain significance
NM_020299.5(AKR1B10):c.907C>G (p.Gln303Glu) single nucleotide variant not specified [RCV004222002] Chr7:134539016 [GRCh38]
Chr7:134223768 [GRCh37]
Chr7:7q33
uncertain significance
NM_020299.5(AKR1B10):c.58A>C (p.Thr20Pro) single nucleotide variant not specified [RCV004125528] Chr7:134527969 [GRCh38]
Chr7:134212721 [GRCh37]
Chr7:7q33
uncertain significance
NM_020299.5(AKR1B10):c.898A>G (p.Asn300Asp) single nucleotide variant not specified [RCV004222001] Chr7:134539007 [GRCh38]
Chr7:134223759 [GRCh37]
Chr7:7q33
uncertain significance
NM_020299.5(AKR1B10):c.391G>A (p.Ala131Thr) single nucleotide variant not specified [RCV004257395] Chr7:134533043 [GRCh38]
Chr7:134217795 [GRCh37]
Chr7:7q33
uncertain significance
NM_020299.5(AKR1B10):c.332A>G (p.His111Arg) single nucleotide variant not specified [RCV004248155] Chr7:134532005 [GRCh38]
Chr7:134216757 [GRCh37]
Chr7:7q33
uncertain significance
NM_020299.5(AKR1B10):c.488G>A (p.Ser163Asn) single nucleotide variant not specified [RCV004254887] Chr7:134536708 [GRCh38]
Chr7:134221460 [GRCh37]
Chr7:7q33
likely benign
GRCh37/hg19 7q31.31-33(chr7:120582003-137699953)x1 copy number loss not specified [RCV003986721] Chr7:120582003..137699953 [GRCh37]
Chr7:7q31.31-33
pathogenic
NM_020299.5(AKR1B10):c.666G>A (p.Lys222=) single nucleotide variant not provided [RCV003885127] Chr7:134537586 [GRCh38]
Chr7:134222338 [GRCh37]
Chr7:7q33
likely benign
NM_020299.5(AKR1B10):c.669A>T (p.Pro223=) single nucleotide variant not provided [RCV003885128] Chr7:134537589 [GRCh38]
Chr7:134222341 [GRCh37]
Chr7:7q33
likely benign
NM_020299.5(AKR1B10):c.672A>G (p.Glu224=) single nucleotide variant not provided [RCV003885129] Chr7:134537592 [GRCh38]
Chr7:134222344 [GRCh37]
Chr7:7q33
likely benign
NM_020299.5(AKR1B10):c.824A>G (p.Gln275Arg) single nucleotide variant not specified [RCV004397466] Chr7:134538276 [GRCh38]
Chr7:134223028 [GRCh37]
Chr7:7q33
uncertain significance
NM_020299.5(AKR1B10):c.226G>A (p.Val76Ile) single nucleotide variant not specified [RCV004397436] Chr7:134530802 [GRCh38]
Chr7:134215554 [GRCh37]
Chr7:7q33
uncertain significance
NM_020299.5(AKR1B10):c.789G>C (p.Lys263Asn) single nucleotide variant not specified [RCV004397460] Chr7:134538241 [GRCh38]
Chr7:134222993 [GRCh37]
Chr7:7q33
uncertain significance
GRCh37/hg19 7q33(chr7:133830628-134886583)x3 copy number gain not provided [RCV004819525] Chr7:133830628..134886583 [GRCh37]
Chr7:7q33
uncertain significance
GRCh37/hg19 7q31.32-36.1(chr7:122190535-149944340)x1 copy number loss not provided [RCV004819354] Chr7:122190535..149944340 [GRCh37]
Chr7:7q31.32-36.1
pathogenic
NM_020299.5(AKR1B10):c.502G>A (p.Glu168Lys) single nucleotide variant not specified [RCV004930398] Chr7:134536722 [GRCh38]
Chr7:134221474 [GRCh37]
Chr7:7q33
uncertain significance
NM_020299.5(AKR1B10):c.295G>T (p.Asp99Tyr) single nucleotide variant not specified [RCV004930401] Chr7:134531968 [GRCh38]
Chr7:134216720 [GRCh37]
Chr7:7q33
uncertain significance
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:477
Count of miRNA genes:375
Interacting mature miRNAs:398
Transcripts:ENST00000359579, ENST00000475559, ENST00000496435, ENST00000498818
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCh38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
597309850GWAS1405924_HAgents acting on the renin-angiotensin system use measurement QTL GWAS1405924 (human)1e-11Agents acting on the renin-angiotensin system use measurement7134530651134530652Human
597269353GWAS1365427_Hmetabolite measurement QTL GWAS1365427 (human)3e-17metabolite measurement7134532400134532401Human
597329855GWAS1425929_Hcolor vision disorder QTL GWAS1425929 (human)0.000001color vision disorder7134538081134538082Human
597112321GWAS1208395_Hdiastolic blood pressure QTL GWAS1208395 (human)2e-14diastolic blood pressurediastolic blood pressure (CMO:0000005)7134530507134530508Human
597270046GWAS1366120_Hmetabolite measurement QTL GWAS1366120 (human)2e-13metabolite measurement7134532400134532401Human
597037562GWAS1133636_Hlung adenocarcinoma, family history of lung cancer QTL GWAS1133636 (human)0.000003lung adenocarcinoma, family history of lung cancer7134534288134534289Human
597456512GWAS1552586_Hdiastolic blood pressure QTL GWAS1552586 (human)4e-11diastolic blood pressurediastolic blood pressure (CMO:0000005)7134535845134535846Human
597207173GWAS1303247_HAgents acting on the renin-angiotensin system use measurement QTL GWAS1303247 (human)4e-10Agents acting on the renin-angiotensin system use measurement7134530651134530652Human
597134009GWAS1230083_Hdiastolic blood pressure QTL GWAS1230083 (human)5e-15diastolic blood pressurediastolic blood pressure (CMO:0000005)7134530507134530508Human
597192470GWAS1288544_Hsystolic blood pressure QTL GWAS1288544 (human)2e-13systolic blood pressuresystolic blood pressure (CMO:0000004)7134530507134530508Human
597055560GWAS1151634_Hsystolic blood pressure QTL GWAS1151634 (human)5e-13systolic blood pressuresystolic blood pressure (CMO:0000004)7134536942134536943Human

Markers in Region
D13S1553  
Human AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map9q34.2-q34.3UniSTS
Cytogenetic Map19q13.4UniSTS
Cytogenetic Map7q33UniSTS
Cytogenetic Map9q33.2UniSTS
Cytogenetic Map2q14.3UniSTS
Cytogenetic Map4p16.1UniSTS
Cytogenetic Map3p21.1-p14.2UniSTS
Cytogenetic Map16p11.2UniSTS
Cytogenetic Map1p34UniSTS
Cytogenetic Map6p21.3UniSTS
Cytogenetic Map19q13.2UniSTS
Cytogenetic Map9q33.3UniSTS
Cytogenetic Map20q13.3UniSTS
Cytogenetic Map20q13.13UniSTS
Cytogenetic Map20q12UniSTS
Cytogenetic Map2p23.3UniSTS
Cytogenetic Map14q32UniSTS
Cytogenetic Map3q29UniSTS
Cytogenetic Map1q42.12UniSTS
Cytogenetic Map16q12.1UniSTS
Cytogenetic Map3p25.3UniSTS
Cytogenetic Map15q15.3UniSTS
Cytogenetic Map16q24.1UniSTS
Cytogenetic Map16p13.11UniSTS
Cytogenetic Map17q25.1UniSTS
Cytogenetic Map19p13.11UniSTS
Cytogenetic Map17q21.33UniSTS
Cytogenetic Map20q11.23UniSTS
Cytogenetic Map17p13UniSTS
Cytogenetic Map19p12UniSTS
Cytogenetic Map1p36.11UniSTS
Cytogenetic Map4q35.1UniSTS
Cytogenetic Map6p25.1UniSTS


Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
entire extraembryonic component
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
1167 2406 2781 2097 3843 1680 2222 4 620 1090 462 2248 6215 5403 51 2622 783 1677 1507 171

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_020299 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011516416 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011516417 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047420634 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054358682 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054358683 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054358684 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_927491 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC078847 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF044961 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF052577 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF524864 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC008837 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BM975664 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BT006794 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH236950 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471070 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068271 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CR541801 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U37100 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENST00000359579   ⟹   ENSP00000352584
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl7134,527,567 - 134,541,412 (+)Ensembl
Ensembl Acc Id: ENST00000475559
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl7134,527,620 - 134,537,087 (+)Ensembl
Ensembl Acc Id: ENST00000496435
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl7134,537,613 - 134,541,408 (+)Ensembl
Ensembl Acc Id: ENST00000498818
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl7134,537,580 - 134,541,408 (+)Ensembl
RefSeq Acc Id: NM_020299   ⟹   NP_064695
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh387134,527,567 - 134,541,412 (+)NCBI
GRCh377134,212,344 - 134,226,166 (+)NCBI
Build 367133,862,939 - 133,876,700 (+)NCBI Archive
HuRef7128,514,188 - 128,528,007 (+)ENTREZGENE
CHM1_17134,146,625 - 134,160,442 (+)NCBI
T2T-CHM13v2.07135,835,650 - 135,849,492 (+)NCBI
CRA_TCAGchr7v27133,556,663 - 133,570,483 (+)ENTREZGENE
Sequence:
RefSeq Acc Id: XM_011516416   ⟹   XP_011514718
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh387134,527,567 - 134,541,412 (+)NCBI
Sequence:
RefSeq Acc Id: XM_011516417   ⟹   XP_011514719
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh387134,527,567 - 134,536,639 (+)NCBI
Sequence:
RefSeq Acc Id: XM_047420634   ⟹   XP_047276590
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh387134,527,567 - 134,539,017 (+)NCBI
RefSeq Acc Id: XM_054358682   ⟹   XP_054214657
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.07135,835,650 - 135,847,098 (+)NCBI
RefSeq Acc Id: XM_054358683   ⟹   XP_054214658
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.07135,835,650 - 135,849,492 (+)NCBI
RefSeq Acc Id: XM_054358684   ⟹   XP_054214659
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.07135,835,650 - 135,844,719 (+)NCBI
RefSeq Acc Id: NP_064695   ⟸   NM_020299
- UniProtKB: Q6FHF3 (UniProtKB/Swiss-Prot),   O75890 (UniProtKB/Swiss-Prot),   A4D1P1 (UniProtKB/Swiss-Prot),   Q8IWZ1 (UniProtKB/Swiss-Prot),   O60218 (UniProtKB/Swiss-Prot),   A4D1P0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_011514719   ⟸   XM_011516417
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_011514718   ⟸   XM_011516416
- Peptide Label: isoform X2
- Sequence:
Ensembl Acc Id: ENSP00000352584   ⟸   ENST00000359579
RefSeq Acc Id: XP_047276590   ⟸   XM_047420634
- Peptide Label: isoform X1
RefSeq Acc Id: XP_054214658   ⟸   XM_054358683
- Peptide Label: isoform X2
RefSeq Acc Id: XP_054214657   ⟸   XM_054358682
- Peptide Label: isoform X1
RefSeq Acc Id: XP_054214659   ⟸   XM_054358684
- Peptide Label: isoform X3
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O60218-F1-model_v2 AlphaFold O60218 1-316 view protein structure

Promoters
RGD ID:7211967
Promoter ID:EPDNEW_H11728
Type:initiation region
Name:AKR1B10_1
Description:aldo-keto reductase family 1 member B10
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H11727  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh387134,527,597 - 134,527,657EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:382 AgrOrtholog
COSMIC AKR1B10 COSMIC
Ensembl Genes ENSG00000198074 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000359579 ENTREZGENE
  ENST00000359579.5 UniProtKB/Swiss-Prot
Gene3D-CATH 3.20.20.100 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000198074 GTEx
HGNC ID HGNC:382 ENTREZGENE
Human Proteome Map AKR1B10 Human Proteome Map
InterPro AKR UniProtKB/TrEMBL
  Aldo/ket_reductase_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Aldo/keto_reductase UniProtKB/Swiss-Prot
  NADP_OxRdtase_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NADP_OxRdtase_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:57016 UniProtKB/Swiss-Prot
NCBI Gene 57016 ENTREZGENE
OMIM 604707 OMIM
PANTHER ALDO/KETO REDUCTASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Aldo_ket_red UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA24676 PharmGKB
PIRSF AKR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS ALDKETRDTASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE ALDOKETO_REDUCTASE_1 UniProtKB/Swiss-Prot
  ALDOKETO_REDUCTASE_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ALDOKETO_REDUCTASE_3 UniProtKB/Swiss-Prot
Superfamily-SCOP NAD(P)-linked oxidoreductase UniProtKB/TrEMBL, UniProtKB/Swiss-Prot
UniProt A4D1P0 ENTREZGENE, UniProtKB/TrEMBL
  A4D1P1 ENTREZGENE
  AK1BA_HUMAN UniProtKB/Swiss-Prot, ENTREZGENE
  O75890 ENTREZGENE
  Q6FHF3 ENTREZGENE
  Q8IWZ1 ENTREZGENE
UniProt Secondary A4D1P1 UniProtKB/Swiss-Prot
  O75890 UniProtKB/Swiss-Prot
  Q6FHF3 UniProtKB/Swiss-Prot
  Q8IWZ1 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-06-07 AKR1B10  aldo-keto reductase family 1 member B10  AKR1B10  aldo-keto reductase family 1, member B10 (aldose reductase)  Symbol and/or name change 5135510 APPROVED