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GENE - TERM ANNOTATION REPORT

RGD ID: 2092
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Akr1b1
Name: aldo-keto reductase family 1 member B1
Acc ID: DOID:8947
Term: diabetic retinopathy
Definition: Disease of the RETINA as a complication of DIABETES MELLITUS. It is characterized by the progressive microvascular complications, such as ANEURYSM, interretinal EDEMA, and intraocular PATHOLOGIC NEOVASCULARIZATION.
Definition Source(s): MESH:D003930
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Akr1b1 IDA 1626080RGDassociated with Diabetes Mellitus, Experimental 
Akr1b1 IEP 8548684RGDprotein:increased expression:retinal astrocyte (rat) 
Akr1b1no_associationISOAKR1B1 (Homo sapiens)8548676RGDassociated with Diabetes Mellitus, Type 2;DNA:promoter:repeat:g.-2008(AC)n (rs35839483) (human) 
Akr1b1susceptibilityISOAKR1B1 (Homo sapiens)8548640RGDassociated with Diabetes Mellitus;DNA:repeats, snp:promoter:multiple (human) 
Akr1b1susceptibilityISOAKR1B1 (Homo sapiens)8548668RGDassociated with Diabetes Mellitus, Type 2;DNA:snp:promoter:g.-106C>T (human) 
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