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C(-106)T polymorphism of the aldose reductase gene and the progression rate of diabetic retinopathy.

Authors: Olmos, P  Bastias, MJ  Vollrath, V  Toro, L  Trincado, A  Salinas, P  Claro, JC  Lopez, JM  Acosta, AM  Miquel, JF  Castro, J 
Citation: Olmos P, etal., Diabetes Res Clin Pract. 2006 Nov;74(2):175-82. Epub 2006 May 15.
Pubmed: (View Article at PubMed) PMID:16701918
DOI: Full-text: DOI:10.1016/j.diabres.2006.03.019

PURPOSE: To study the C(-106)T polymorphism in the promoter of the aldose reductase (ALR2) gene: (a) its local prevalence and (b) its modulation of the susceptibility for developing retinopathy. METHODS: DNAs of 96 control subjects and 53 long-standing (duration 17.9+/-5.4 years) type-2 diabetic patients were analyzed by PCR-RFLP with BfaI enzyme. Retinopathy was graded with 2-eye, 7-field fundus color photography. The IMF-HbA1c was the arithmetic mean of all HbA1c's of each patient. RESULTS: The genotypes in the controls were CC=57 (59.4%), CT=32 (33.3%) and TT=7 (7.3%), with Hardy-Weinberg chi(2)=0.793 (p>0.50). Among 53 diabetics, CC=24 (45.3%), CT=26 (49.0%) and TT=3 (5.7%). The correlation between IMF-HbA1c and retinopathy progression rate was significant on CC (r=0.6102, p=0.0072) but not in CT+TT genotypes (r=0.26, p=0.1811). CONCLUSIONS: In Chilean adults, the frequency of the C(-106)T polymorphism of the ALR2 gene was similar to that reported by others. Type-2 diabetics with the CC genotype were more susceptible for developing retinopathy as a result of chronic hyperglycemia than those with the CT or TT genotype.

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RGD Object Information
RGD ID: 8548668
Created: 2014-03-18
Species: All species
Last Modified: 2014-03-18
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.